CN108403465A - A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof - Google Patents
A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The present invention proposes a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and preparation method thereof, including 6.5 10.5% surfactants, 0.5 2.5% polyhexamethylene guanide/biguanide hydrochloride, 8.5 12.5% amphoteric surfactantes, 1.0 3.0% nonionic surfactants, 1.5 3.5% glyceryl cocoates, 0.3 0.7% preservative, 0.5 1.1% pearling agent, 1.5 3.5% thickeners, 0.8 1.6% chelating agent, 0.5 2.5% citric acid, 0.3 0.9% carboxymethyl cellulose, remaining be deionized water；Polyhexamethylene guanide/biguanide hydrochloride is added in the configuration solution of hand cleanser of the present invention, multiple absorption point can be formed between skin, lysozyme with block cell and bactericidal effect, and to skin and eyes without any stimulation, so the hand cleanser safety higher with polyhexamethylene guanide/biguanide hydrochloride.
Description
Technical field
The present invention relates to hand cleanser field more particularly to a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and its systems
Preparation Method.
Background technology
Hand is to be in the most contact with the external world in human body and be easiest to dirty position, can usually be carried on the surface of hand
Various germs.On the one hand, in daily life and work, both hands can be contacted inevitably with microorganism people, or even be caused a disease
The article of microorganism, to make both hands bacterial infection.Still further aspect, the chance due to the public contacts of modern society people and way
Diameter increases, and in public arenas such as family, hotel, restaurant, airport, station and hospitals, people are caught an illness the chance of bacterium by feel
Increase.Especially medical personnel, in work such as the diagnosis and treatment of patient, nursing, physical examination and dressings, handle caused by directly and
The germ infection of indirect occupies first place.Epidemiological survey confirms that the bacterium on hand of 98% or more medical worker seriously surpasses
Mark, the approach ratio air borne directly or indirectly to be spread germs by the hand of doctor and nurse have more generality and danger.
Therefore the sanitation and hygiene for keeping hand ensure that health has very important significance to preventing disease.
With the enhancing of people's health care consciousness and the pursuit of concept of health so that it is strong that people increasingly pay close attention to the body of oneself
Health.Therefore studying a kind of not only can kill with dirt-removing functions but also simultaneously the potent disinfecting cleaning hand cleanser of hand microorganism with weighing
The meaning wanted.
Consult existing correlation technique data, be related at present hand cleanser products and technology containing PHMB mainly have it is following several
Kind：
(1) Chinese patent discloses (bulletin) number：CN101548983A discloses a kind of skin antiseptic and preparation method thereof；
CN101912409A discloses a kind of aerial fog disinfectant and preparation method；CN102265894A, which is disclosed, a kind of killing microorganism
Composition and preparation method thereof, in these three formulas, although having selected polyhexamethylene guanide/biguanide hydrochloride as disinfectant,
But in formula since a large amount of ethyl alcohol are added, there is a very strong sharp aroma, long-time service can also cause hand skin allergy, thick
The problem of rough, dry and cracked and decortication.
(2) Chinese patent discloses (bulletin) number：CN1476761A discloses a kind of liquid high effect disinfectants and its preparation side
Method；CN1786134A discloses a kind of multifunction antiseptic sterilizing cleaning agent composition and preparation method thereof, is adopted in the two formulas
With 3 kinds of disinfectant combined sterilizings, and it is equipped with Multiple components.Two kinds of formula material complexity, cost is higher, and contains aldehyde in being formulated
Class or chlorine class disinfectant, smell is big, has serious stimulation, long-time service that can cause skin allergy human skin, mucous membrane
Phenomenon, and remain seriously, it pollutes the environment.
(3) Chinese patent discloses (bulletin) number：CN101684435A discloses a kind of disinfection hand cleanser and preparation method thereof；
CN102018634A discloses a kind of compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method thereof；CN101810186A is disclosed
A kind of multifunctional disinfectant and preparation method thereof, material composition is more in these three formulas, and preparation process is cumbersome, technique is multiple
Miscellaneous, cost is higher.
Therefore, in view of the deficiencies of the prior art, the present invention propose a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser and
Preparation method is to solve problems of the prior art.
Invention content
In view of the above-mentioned problems, a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser of present invention proposition and preparation method thereof,
Polyhexamethylene guanide/biguanide hydrochloride is added in the configuration solution of the hand cleanser, the guanidine radicals in the substance has very high activity,
Be dissolved in after water into electropositive, the anion Electrostatic Absorption of cation and microbial cell surface in molecule, block cell it is molten
Bacterium enzyme effect makes cell surface structural degeneration or destruction, to can largely inhibit bacterial reproduction and kill bacterium, and
To skin and eyes without any stimulation, no sensitization, so the hand cleanser safety with polyhexamethylene guanide/biguanide hydrochloride
Higher, property are more stable.
The present invention proposes a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser, the composition containing following mass ratio：6.5-
10.5% surfactant, 0.5-1.5% polyhexamethylene guanides/biguanide hydrochloride, 8.5-12.5% amphoteric surfactantes,
1.0-3.0% nonionic surfactants, 1.5-3.5% glyceryl cocoates, 0.3-0.7% methylchloroisothiazandnones,
0.5-1.1% pearling agents, 1.5-3.5% thickeners, 0.8-1.6% chelating agents, 0.5-2.5% citric acids, 0.3-0.9% carboxylic first
Base cellulose, remaining is deionized water.
Further improvement lies in that：The polyhexamethylene guanide/biguanide hydrochloride hand cleanser contains the composition of following mass ratio：
8.5% surfactant, 1.0% polyhexamethylene guanide/biguanide hydrochloride, 10.5% amphoteric surfactant, 2.0% nonionic
Surfactant, 2.5% glyceryl cocoate, 0.5% methylchloroisothiazandnone, 0.8% pearling agent, 2.5% thickener,
1.2% chelating agent, 1.5% citric acid, 0.6% carboxymethyl cellulose, remaining is deionized water.
Further improvement lies in that：The amphoteric surfactant is dodecyl ethyoxyl sulfobetaines, dodecyl
One or more of benzene sulfonic acid sodium salt, decyl dimethyl hydroxypropyl sulfobetaines mix.
Further improvement lies in that：The nonionic surfactant is ethoxylated dodecyl alcohol, 12-14 carbon primary alconol polyoxies
One or more of vinethene, octanol polyoxyethylene ether mix.
Further improvement lies in that：The pearling agent is one kind in stearic acid diethylene glycol dilaurate, stearic acid ethylene glycol ester
Or a variety of mixing.
Further improvement lies in that：The thickener is the mixing of one or more of sodium chloride, ammonium chloride, potassium chloride.
Applied to a kind of preparation method of above-mentioned polyhexamethylene guanide/biguanide hydrochloride hand cleanser, include the following steps：
Step 1：Citric acid is configured to the citric acid solution that PH is 3-6；
Step 2：Carboxymethyl cellulose is added in above-mentioned citric acid solution, after being heated to 30-70 degrees Celsius
It is stirred；
Step 3：Mixed solution to carboxymethyl cellulose is added is tested, and suitable citric acid pair is added again
Mixed solution is adjusted, by pH value adjustment to 5.5-6.5 after stirring；
Step 4：Successively to surfactant, polyhexamethylene guanide/biguanides, amphoteric surface are added in above-mentioned mixed solution
Activating agent, nonionic surfactant, glyceryl cocoate, methylchloroisothiazandnone, chelating agent, deionized water keep temperature
Degree is again stirring at 50-80 degrees Celsius；
Step 5：Cooling processing is carried out, and to glyceryl cocoate, pearling agent are added in above-mentioned solution, and is stirred；
Step 6：Under stiring, slowly 1-3h is stirred to thickener is added in above-mentioned solution；
Step 7：Stewing process is carried out to above-mentioned solution, is de-gassed after defoaming, polyhexamethylene guanide/bis- is obtained
Guanidine hydrochloride hand cleanser.
Further improvement lies in that：Mixing time in the step 2 is 20-60min.
Further improvement lies in that：Mixing time in the step 4 is 2-6h.
Further improvement lies in that：Time of repose in the step 7 is 1-3h, and waits for hand cleanser semi-finished product solution surface
Dissipation of air bubbles is de-gassed later to every 5 Ge/㎡.
Beneficial effects of the present invention：
1. the guanidine salt class antibacterial finishing agent in polyhexamethylene guanide of the present invention/biguanide hydrochloride hand cleanser has good peace
Full property and durability are considered as applying preferable antibacterial finishing agent at present, and polyhexamethylene guanide/biguanide hydrochloride is cation
Oligomer is distributed as 16 or 16 or more biguanide units, and each biguanide units have 2 cation groups, high molecular weight
Polyhexamethylene guanide/multiple absorption point can be formed between biguanide hydrochloride and skin, antibacterial strength is higher, and by poly- six methylene
Hand cleanser made of base guanidine/biguanide hydrochloride after people washes hand have good bacterium resistant function, will not make bacterium according to
It is attached on the skin.
2. polyhexamethylene guanide of the present invention/biguanide hydrochloride hand cleanser toxicity itself is extremely low, LD50 ＞ 5000mg/kg are right
Skin and eyes are without any stimulation, no sensitization, so the hand cleanser safety with polyhexamethylene guanide/biguanide hydrochloride is more
Height, property are more stable.
3. adding nonionic surfactant in the present invention, good dispersion, emulsification and osmosis are made it have,
Sterilization and fungistatic effect are strengthened, coordinates glyceryl cocoate, layer protecting film can be left after skin surface moisture evaporation, subtracted
Water loss inside slow skin, protects the wettability of skin.
4. polyhexamethylene guanide/biguanide hydrochloride makees fungicide as hand cleanser in the present invention, it is not required to addition dyestuff and perfume (or spice)
Essence, product characteristics are colourless transparent liquids, there is fragranced, store for a long time it is non-discolouring, make in a long time after use skin there are
Aromatic odor.
Specific implementation mode
In order to which so that invention is realized technological means, reached purpose and effect are easy to understand, with reference to specific implementation
Mode, the present invention is further explained.
Embodiment one
A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser, the composition containing following mass ratio：6.5% surface-active
Agent, 2.5% polyhexamethylene guanide/biguanide hydrochloride, 8.5% amphoteric surfactant, 3.0% nonionic surfactant,
1.5% glyceryl cocoate, 0.7% preservative, 0.5% pearling agent, 3.5% thickener, 0.8% chelating agent, 2.5% lemon
Acid, 0.3% carboxymethyl cellulose, remaining be deionized water.
Step 1：Citric acid is configured to the citric acid solution that PH is 3-6；
Step 2：Carboxymethyl cellulose is added in above-mentioned citric acid solution, after being heated to 30-70 degrees Celsius
It is stirred；
Step 3：Mixed solution to carboxymethyl cellulose is added is tested, and suitable citric acid pair is added again
Mixed solution is adjusted, by pH value adjustment to 5.5-6.5 after stirring；
Step 4：Successively to surfactant, polyhexamethylene guanide/biguanides, amphoteric surface are added in above-mentioned mixed solution
Activating agent, nonionic surfactant, glyceryl cocoate, methylchloroisothiazandnone, chelating agent, deionized water keep temperature
Degree is again stirring at 50-80 degrees Celsius；
Step 5：Cooling processing is carried out, and to glyceryl cocoate, pearling agent are added in above-mentioned solution, and is stirred；
Step 6：Under stiring, slowly 1-3h is stirred to thickener is added in above-mentioned solution；
Step 7：Stewing process is carried out to above-mentioned solution, is de-gassed after defoaming, polyhexamethylene guanide/bis- is obtained
Guanidine hydrochloride hand cleanser.
In the present embodiment：Mixing time in the step 2 is 20-60min.
In the present embodiment：Mixing time in the step 4 is 2-6h.
In the present embodiment：Time of repose in the step 7 is 1-3h, and waits for hand cleanser semi-finished product solution surface gas
Bubble is dissipated to every 5 Ge/㎡, is de-gassed later.
Embodiment two
A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser, the composition containing following mass ratio：8.5% surface-active
Agent, 1.5% polyhexamethylene guanide/biguanide hydrochloride, 10.5% amphoteric surfactant, 2.0% nonionic surfactant,
2.5% glyceryl cocoate, 0.5% preservative, 0.8% pearling agent, 2.5% thickener, 1.2% chelating agent, 1.5% lemon
Acid, 0.6% carboxymethyl cellulose, remaining be deionized water.
Step 1：Citric acid is configured to the citric acid solution that PH is 3-6；
Step 2：Carboxymethyl cellulose is added in above-mentioned citric acid solution, after being heated to 30-70 degrees Celsius
It is stirred；
Step 3：Mixed solution to carboxymethyl cellulose is added is tested, and suitable citric acid pair is added again
Mixed solution is adjusted, by pH value adjustment to 5.5-6.5 after stirring；
Step 4：Successively to surfactant, polyhexamethylene guanide/biguanides, amphoteric surface are added in above-mentioned mixed solution
Activating agent, nonionic surfactant, glyceryl cocoate, methylchloroisothiazandnone, chelating agent, deionized water keep temperature
Degree is again stirring at 50-80 degrees Celsius；
Step 5：Cooling processing is carried out, and to glyceryl cocoate, pearling agent are added in above-mentioned solution, and is stirred；
Step 6：Under stiring, slowly 1-3h is stirred to thickener is added in above-mentioned solution；Step 7：To above-mentioned solution
Stewing process is carried out, is de-gassed after defoaming, obtains polyhexamethylene guanide/biguanide hydrochloride hand cleanser.
In the present embodiment：Mixing time in the step 2 is 20-60min.
In the present embodiment：Mixing time in the step 4 is 2-6h.
In the present embodiment：Time of repose in the step 7 is 1-3h, and waits for hand cleanser semi-finished product solution surface gas
Bubble is dissipated to every 5 Ge/㎡, is de-gassed later.
Embodiment three
A kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser, the composition containing following mass ratio：10.5% surface-active
Agent, 0.5% polyhexamethylene guanide/biguanide hydrochloride, 12.5% amphoteric surfactant, 1.0% nonionic surfactant,
3.5% glyceryl cocoate, 0.3% preservative, 1.1% pearling agent, 1.5% thickener, 1.6% chelating agent, 0.5% lemon
Acid, 0.9% carboxymethyl cellulose, remaining be deionized water.
Step 1：Citric acid is configured to the citric acid solution that PH is 3-6；
Step 2：Carboxymethyl cellulose is added in above-mentioned citric acid solution, after being heated to 30-70 degrees Celsius
It is stirred；
Step 3：Mixed solution to carboxymethyl cellulose is added is tested, and suitable citric acid pair is added again
Mixed solution is adjusted, by pH value adjustment to 5.5-6.5 after stirring；
Step 4：Successively to surfactant, polyhexamethylene guanide/biguanides, amphoteric surface are added in above-mentioned mixed solution
Activating agent, nonionic surfactant, glyceryl cocoate, methylchloroisothiazandnone, chelating agent, deionized water keep temperature
Degree is again stirring at 50-80 degrees Celsius；
Step 5：Cooling processing is carried out, and to glyceryl cocoate, pearling agent are added in above-mentioned solution, and is stirred；
Step 6：Under stiring, slowly 1-3h is stirred to thickener is added in above-mentioned solution；
Step 7：Stewing process is carried out to above-mentioned solution, is de-gassed after defoaming, polyhexamethylene guanide/bis- is obtained
Guanidine hydrochloride hand cleanser.
In the present embodiment：Mixing time in the step 2 is 20-60min.
In the present embodiment：Mixing time in the step 4 is 2-6h.
In the present embodiment：Time of repose in the step 7 is 1-3h, and waits for hand cleanser semi-finished product solution surface gas
Bubble is dissipated to every 5 Ge/㎡, is de-gassed later.
Comparison, which is carried out, according to above example one, embodiment two and embodiment three show that in the present invention, quality compares composition
For：6.5-10.5% surfactants, 0.5-1.5% polyhexamethylene guanides/biguanide hydrochloride, 8.5-12.5% amphoteric surfaces live
Property agent, 1.0-3.0% nonionic surfactants, 1.5-3.5% glyceryl cocoates, 0.3-0.7% methyl chloride isothiazolines
Ketone, 0.5-1.1% pearling agents, 1.5-3.5% thickeners, 0.8-1.6% chelating agents, 0.5-2.5% citric acids, 0.3-0.9%
Carboxymethyl cellulose, when remaining is deionized water, by washing one's hands with postponing the polyhexamethylene guanide/biguanide hydrochloride obtained
Liquid sterilizing ability is most strong, inhibits bacterial reproduction effect more preferable, stability and dirt-removing power higher, and protection skin moisturization is more preferable.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the present invention is not limited to the above embodiments, and the above embodiments and description only describe the originals of the present invention
Reason, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements
It all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appending claims and equivalents circle
It is fixed.
Claims (10)
1. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser, it is characterised in that：Composition containing following mass ratio：6.5-
10.5% surfactant, 0.5-1.5% polyhexamethylene guanides/biguanide hydrochloride, 8.5-12.5% amphoteric surfactantes,
1.0-3.0% nonionic surfactants, 1.5-3.5% glyceryl cocoates, 0.3-0.7% methylchloroisothiazandnones,
0.5-1.1% pearling agents, 1.5-3.5% thickeners, 0.8-1.6% chelating agents, 0.5-2.5% citric acids, 0.3-0.9% carboxylic first
Base cellulose, remaining is deionized water.
2. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 1, it is characterised in that：Containing such as
The composition of lower mass ratio：8.5% surfactant, 1.0% polyhexamethylene guanide/biguanide hydrochloride, 10.5% amphoteric surface live
Property agent, 2.0% nonionic surfactant, 2.5% glyceryl cocoate, 0.5% methylchloroisothiazandnone, 0.8% pearly-lustre
Agent, 2.5% thickener, 1.2% chelating agent, 1.5% citric acid, 0.6% carboxymethyl cellulose, remaining is deionized water.
3. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 1, it is characterised in that：Described two
Property surfactant be dodecyl ethyoxyl sulfobetaines, neopelex, decyl dimethyl hydroxypropyl sulphur
One or more of base glycine betaine mixes.
4. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 1, it is characterised in that：It is described non-
Ionic surface active agent is one kind in ethoxylated dodecyl alcohol, 12-14 carbon primary alconols polyoxyethylene ether, octanol polyoxyethylene ether
Or a variety of mixing.
5. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 1, it is characterised in that：The pearl
Photo etching is the mixing of one or more of stearic acid diethylene glycol dilaurate, stearic acid ethylene glycol ester.
6. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 1, it is characterised in that：The increasing
Thick dose is the mixing of one or more of sodium chloride, ammonium chloride, potassium chloride.
7. the preparation method applied to a kind of above-mentioned polyhexamethylene guanide/biguanide hydrochloride hand cleanser, it is characterised in that：Including
Following steps：
Step 1：Citric acid is configured to the citric acid solution that PH is 3-6；
Step 2：Carboxymethyl cellulose is added in above-mentioned citric acid solution, is carried out after being heated to 30-70 degrees Celsius
Stirring；
Step 3：Mixed solution to carboxymethyl cellulose is added is tested, and suitable citric acid is added again to mixing
Solution is adjusted, by pH value adjustment to 5.5-6.5 after stirring；
Step 4：Successively to surfactant, polyhexamethylene guanide/biguanides, amophoteric surface active are added in above-mentioned mixed solution
Agent, nonionic surfactant, glyceryl cocoate, methylchloroisothiazandnone, chelating agent, deionized water, maintain the temperature at
It 50-80 degrees Celsius, is again stirring for；
Step 5：Cooling processing is carried out, and to glyceryl cocoate, pearling agent are added in above-mentioned solution, and is stirred；
Step 6：Under stiring, slowly 1-3h is stirred to thickener is added in above-mentioned solution；
Step 7：Stewing process is carried out to above-mentioned solution, is de-gassed after defoaming, obtains polyhexamethylene guanide/Guanoctine
Hydrochlorate hand cleanser.
8. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 7 and preparation method thereof, feature
It is：Mixing time in the step 2 is 20-60min.
9. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 7 and preparation method thereof, feature
It is：Mixing time in the step 4 is 2-6h.
10. a kind of polyhexamethylene guanide/biguanide hydrochloride hand cleanser according to claim 7 and preparation method thereof, special
Sign is：Time of repose in the step 7 is 1-3h, and wait for hand cleanser semi-finished product solution blibbing be dissipated to every 5/
㎡ is de-gassed later.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112336671A (en) * | 2020-11-20 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Skin-care disinfectant and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
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