CN101933513A - Compound washing-free disinfection composition and preparation method thereof - Google Patents
Compound washing-free disinfection composition and preparation method thereof Download PDFInfo
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- CN101933513A CN101933513A CN2010102242420A CN201010224242A CN101933513A CN 101933513 A CN101933513 A CN 101933513A CN 2010102242420 A CN2010102242420 A CN 2010102242420A CN 201010224242 A CN201010224242 A CN 201010224242A CN 101933513 A CN101933513 A CN 101933513A
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Abstract
The invention provides a compound washing-free disinfection composition and a preparation method thereof. The compound washing-free disinfection composition adopts bi-component bactericidal active ingredients and is mainly applied to the medical industry, hand-washing disinfection of bank financial staffs, skin disinfection, surface disinfection of public environments, personal hygiene care and the like, and compared with a common hand-washing disinfectant, the compound washing-free disinfection composition has the characteristics of convenient use, no need of re-flushing, low skin irritation, safety, sanitation, and quick and clean sterilization, so the compound washing-free disinfection composition is an effective preparation for preventing bacterial and virus cross infection in peacetime and in a sudden serious infectious disease epidemic situation.
Description
Technical field
The present invention relates to disposable sanitizing composition of a kind of novel compound and preparation method, adopt two component fungicide active ingredients, be mainly used in handwashing disinfection, skin degerming, public environment surface sterilization, personal hygiene nursing of medical industry personnel etc., compare with common handwashing disinfection agent have easy to use, need be with washing again, skin irritation is low, the fast clean characteristics of safety and sanitation, sterilization, is the effective preparation that prevents bacterium and viral cross-infection.
Background technology
Wash one's hands and the application of skin antiseptic at aspects such as medical industry, daily lifes have crucial meaning, to prevent and prevent epiphytotics spread with cross-infection be a link of not replacing, be mainly used in the scouring of the medical personnel of hospital hand, skin, diagnostic equipment, daily necessities, tableware, toy for children and sterilization etc.Wash one's hands with soap, clean the history of skin existing several centuries in Europe, this hygienic habit is being eliminated the metabolic refuse of human body self, the bacterium of body surface and minimizing contact bacterium intercrossing infect and have certain positive effect and effect, but along with development of times, human living standard's continuous raising, and the procreation of human communicable disease kind and variation, human beings'health huge infringement and threat have been caused, therefore human requirement and becoming increasingly complex of becoming of the means taked to the health defence, the defense reaction that has been difficult to accomplish disease with general washing agent, therefore professional and functional disinfectant uses and gives birth to, stink and disinfective action that French medicine expert Labarraque discovery in 1822 can be removed corpse with the aqueous solution of chlorine, in the paper that he delivered in 1825, think for doctor and participation nursing contagiosity patient's personnel, adopt solutions of chlorine wiping and wetting hand to bring benefit to them.1847, Semmelweis adopted the antibacterial detergent washing because medical personnel contact patient at work by the hand of heavily contaminated by a large amount of disinfectant clinical testing proofs, reduces communicable disease than washing one's hands with common soap and has better effect.
The guideline of u.s. department of health and hospital infection control association, require patient of the every contact of medical personnel, all require handwashing disinfection once, each nurse is a process on duty, if must wash about 100 times by national requirements, yet contain water in long-term use, washing agent and sterilization component hand cleanser, irritation appears in people's skin, as red swelling of the skin, decortication, fester and the generation of all kinds of allergic dermatitises, therefore people begin to develop the detergent with sterilizing that does not wash with water, found afterwards to adopt alcohols can produce bactericidal activity efficiently as solvent and the compound of other sterilization factors, spread upon on the skin and can volatilize rapidly owing to this type of disinfectant again, non-flushing washing reduced the injury to skin.The U.S.'s one disposable disinfectant patent report; adopt isopropyl alcohol and a spot of water, adopt hydrogen peroxide as disinfection factor; it is fast to have sterilization; fungicidal spectrum is not extensively, wash with water; the characteristics that can directly clean, though added Derma-Guard in Recipe, hydrogen peroxide is the strong and chemical substance of poor stability of a kind of oxidisability; thereby skin and mucous membrane caused heavier stimulation, pachylosis, bleaching and red and swollen phenomenon etc. appear.Therefore a kind of safety and environmental protection, easy to use, good stability be provided, do not wash with water, sterilization wide spectrum, formulation products that excitant is low be very technological innovation and the development that actual use meaning is arranged.
Summary of the invention
The present invention relates to disposable sanitizing composition of a kind of compound and preparation method, adopt nontoxic non-stimulated macromolecular material as compositions such as the sterilization factors of dressing, non-stimulated alcohols, safety and environmental protection, stabilizing agent, wetting agent, skin-care agents.Skin and hand that its medical personnel, casual health entertainment service personnel, public communication place, diplomat, bank's point banknote staff, accounting, tourist party, bus that is mainly used in medical and health industry is transported system personnel, household person are disinfected.
The disposable sanitizing composition of compound of the present invention is mainly realized by following design:
Disposable sterilization combination of compound and preparation method
This sanitizing composition comprises following composition and weight portion proportioning: this thimerosal comprises following composition and weight portion proportioning: intercalating agent 0-1 part, aliphatic alcohols 30-70 part, diphenyl ether compound 0-1 part, high polymer 0-5 part, humectant 0-1 part, bleeding agent 0-2 part, spices 0-1 part, deionized water 20-60 part.The state of this disinfectant when not adding pigment is the water white transparency colloid, can flow, and also can not flow, and controlled by viscosity.System pH is at 5-8.Smear the sterilization and the cleaning that are applied to human body skin, hand, environment, body surface.
Intercalating agent comprises: one or more in nitrilotriacetic acid trisodium, Etidronic Acid, ethylenediamine tetra-acetic acid, disodium ethylene diamine tetraacetate, tetrasodium ethylenediamine tetraacetate, ethylenediamine tetra-acetic acid potassium sodium, B,EDTA, amino trimethylene methyl acid phosphate five sodium, and as synergy, stablize auxiliary material.
Diphenyl ether compound comprises: 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether, 2,3,4 '-three chloro-2 '-dihydroxy diphenyl ether, 3,4 '-diamines yl diphenyl ether, 3,4 '-dichloro-diphenyl ether, 4,4 '-wherein one or more of dinitro diphenyl ether, as active component.Aliphatic alcohols comprises: ethanol, ethylene glycol, propyl alcohol, isopropyl alcohol, propane diols, glycerine, butanols, 1, one or more in the 3-butanediol.As bactericidal active agent.
High polymer comprises: Sodium Polyacrylate, PEG2000, PEG3000, polychlorostyrene is for Trimethylamine ethyl-methyl acrylate, the two hard acid esters of PEG6000, methylcellulose, ethyl cellulose, propyl cellulose, cellulose acetate, hydroxymethyl-propyl cellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, Sodium Hydroxymethyl Stalcs, Sodium Hydroxymethyl Stalcs, microcrystalline cellulose, carbopol940, carbopol941, carbopol942, carbopol2020, cellulose acetate-phthalate, wherein one or more of PVPk35.
Bleeding agent comprises: wherein one or more of diglycerol base list olive grease, azone, octyldodecanol, PEG-(40) rilanit special, crocodile plough oil, N-Methyl pyrrolidone.Humectant comprises: wherein one or more of monoolein, PEG400, PEG600, protein hydrolysate, several butyl of carboxymethyl-D panthenol, hyaluronic acid.
Preparation main method of the present invention and step are as follows:
1, presses 20-60 part deionized water earlier, after the weighing deionized water is joined reactor;
2, stirring adds reactor down according to aliphatic alcohols 30-70 part after the weighing;
3, the intercalating agent with 0-1 part joins in the reactor, stirs intensification and is controlled at 30 ℃-60 ℃.
4, the diphenyl ether compound active component that adds metering 0-1 part while stirring.
5, the 0-5 part high polymer class that adds metering while stirring is stirred well to it is uniformly dispersed fully.
6, add accurately 0-2 part bleeding agent of metering while stirring, fully stirring is dissolved it fully.
7, add accurately 0-1 part humectant of metering while stirring, the spices of 0-1 part dissolves it fully and is uniformly dispersed.Backflow 10-20min.
8, when 25 ℃ of solution temperatures, adopt acidometer accurately to monitor, and the pH value of regulator solution is between 5.0-8.0.Final product be transparent, can flow or the immobilising colloidal state preparation that certain viscosity is arranged.
Embodiment
Embodiment 1
Nitrilotriacetic acid trisodium 0-0.2 part, 1,3-butanediol 40-60 part, 2,3,4 '-three chloro-2 '-dihydroxy diphenyl ether 0-0.5 part, sodium carboxymethylcellulose 0-2 part, hyaluronic acid 0-1 part, diglycerol base list olive grease 0-1 part, spices 0-1 part, deionized water 30-40 part.The present invention realizes by following steps:
According to 30-40 part deionized water, after the weighing deionized water is joined reactor earlier; According to 1,3-butanediol 40-60 part adds reactor after the weighing under stirring; The nitrilotriacetic acid trisodium is joined in the reactor for 0 0.2 parts, stir intensification and be controlled at 30-50 ℃; 2,3,4 '-three chloro-2 of adding metering while stirring '-dihydroxy diphenyl ether 0-0.5 part active component; The sodium carboxymethylcellulose 0-2 part that adds metering while stirring is stirred well to it is uniformly dispersed fully; Add accurately diglycerol base list olive grease 0-1 part of metering while stirring, fully stirring is dissolved it fully; Add accurately hyaluronic acid 0-1 part of metering while stirring, the spices of 0-1 part dissolves it fully and is uniformly dispersed.Backflow 10-20min.When 25 ℃ of solution temperatures, adopt acidometer accurately to monitor, and the pH value of regulator solution is between 5.0-8.0.Final product is the colloidal state preparation that certain viscosity is arranged transparent, that can flow and maybe can not flow, and flow regime is determined by viscosity.
Embodiment 2
Disodium ethylene diamine tetraacetate 0-0.1 part, ethanol 50-60 part, 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0-0.3 part, carbopol2020 0-0.5 part, PEG400 0-0.2 part, azone 0-0.3 part, spices 0-1 part, deionized water 20-40 part.The pH value of regulator solution is between 5.0-8.0.Final product is the colloidal state preparation that certain viscosity is arranged transparent, that can flow and maybe can not flow.
Embodiment 3
Disodium ethylene diamine tetraacetate 0-0.1 part, isopropyl alcohol 50-60 part, glycerine 0-3 part, 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0-0.3 part, carbopol942 0-1 part, several butyl of carboxymethyl-D panthenol 0-0.2 part, azone 0-0.3 part, spices 0-0.1 part, deionized water 30-50 part.The pH value of regulator solution is between 5.0-8.0.Final product is the colloidal state preparation that certain viscosity is arranged transparent, that can flow and maybe can not flow.The present invention mainly prepares by following technology:
According to 30-50 part deionized water, after the weighing deionized water is joined reactor earlier; According to isopropyl alcohol 50-60 part, glycerine 0-3 part adds reactor after the weighing under stirring; Disodium ethylene diamine tetraacetate 0-0.1 part is joined in the reactor, stir intensification and be controlled at 30 ℃ 0-60 ℃; 2,4,4 '-three chloro-2 of adding metering while stirring '-dihydroxy diphenyl ether 0-0.3 part active component; The carbopol942 0-1 part that adds metering while stirring is stirred well to it is uniformly dispersed fully; Add accurately azone 0-0.3 part of metering while stirring, fully stirring is dissolved it fully; Add accurately several butyl of carboxymethyl-D panthenol 0-0.2 part of metering while stirring, the spices of 0-0.1 part dissolves it fully and is uniformly dispersed.Backflow 10-20min.When 25 ℃ of solution temperatures, adopt acidometer accurately to monitor, and the pH value of regulator solution is between 5.0-8.0.Final product is the colloidal state preparation that certain viscosity is arranged transparent, that can flow and maybe can not flow, mainly controls flowability by viscosity.
Embodiment 4
Tetrasodium ethylenediamine tetraacetate 0-1 part, ethanol 50-70 part, propane diols 0-3 part, 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0-1 part, Sodium Polyacrylate 0-2 part, PEG600 0-0.2 part, PEG-(40) rilanit special 0-0.3 part, spices 0-0.3 part, deionized water 20-30 part.The pH value of regulator solution is between 5.0-8.0.Final product is the colloidal state preparation that certain viscosity is arranged transparent, that can flow and maybe can not flow, and flow regime and ability are influenced by viscosity mainly, the relation of being inversely proportional to.
Test data that the present invention is relevant and result:
1. test basis: Ministry of Public Health's " disinfection technology standard " (version in 2002), 2.1.1.5. and 2.1.1.7 (2002.11)
2. neutralizer approval test: test with disposable disinfectant stock solution, sterilizing time is 3 minutes, in and the time be 10 minutes.Test temperature is 20 ℃ ± 1 ℃, the test triplicate.
3. bactericidal assay: test test temperature with the solution of disposable disinfectant stock solution, 80% dilution, 60% dilution respectively.
Kill test: the solution with disposable disinfectant stock solution, 80% dilution, 60% dilution is tested, and test temperature is 20 ℃ ± 1 ℃, triplicate.
Under test temperature, prove through result of the test, the PBS neutralizer that contains 1% sodium thiosulfate, 0.5% lecithin, 1% Tween 80, under the disinfectant stock solution situation, Escherichia coli 8099 carriers are soaked in quantitative disinfecting test, the neutralizer approval test, the residual toxicity of this disinfectant that can effectively neutralize, and to the test organisms avirulence, medium is had no adverse effects.So can be used as the neutralizer of this disinfectant.
The killing effect of the disposable disinfectant Escherichia coli 8099 of table 1 the present invention
Under test temperature, prove through result of the test, disposable disinfectant stock solution effect 1min to Escherichia coli 8099 killing rate logarithm value greater than 3.00, disposable disinfectant 80% dilution effect 1min to Escherichia coli 8099 killing rate logarithm value greater than 3.00, disposable disinfectant 60% dilution effect 1min, 3min, 5min to Escherichia coli 8099 killing rate logarithm value be respectively 3.18,＞3.00
Under test temperature, prove through result of the test, the PBS neutralizer that contains 1% sodium thiosulfate, 0.5% lecithin, 1% Tween 80, under the disinfectant stock solution situation, staphylococcus aureus ATCC6538 carrier is soaked in quantitative disinfecting test, the neutralizer approval test, the residual toxicity of this disinfectant that can effectively neutralize, and to the test organisms avirulence, medium is had no adverse effects.So can be used as the neutralizer of this disinfectant.
The disposable disinfectant staphylococcus aureus of table 2 the present invention ATCC6538 killing effect
Under test temperature, prove through result of the test, disposable disinfectant stock solution effect 1min to staphylococcus aureus ATCC6538 killing rate logarithm value greater than 3.00, disposable disinfectant 80% dilution effect 1min to staphylococcus aureus ATCC6538 killing rate logarithm value greater than 3.00, disposable disinfectant 60% dilution effect 1min, 3min, 5min to staphylococcus aureus ATCC6538 killing rate logarithm value be respectively 3.45,＞3.00,＞3.00.
The killing effect of the disposable disinfectant Candida albicans of table 3 ATCC10231
Under test temperature, prove through result of the test, the PBS neutralizer that contains 1% sodium thiosulfate, 0.5% lecithin, 1% Tween 80, under the disinfectant stock solution situation, Candida albicans ATCC10231 carrier is soaked in quantitative disinfecting test, the neutralizer approval test, the residual toxicity of this disinfectant that can effectively neutralize, and to the test organisms avirulence, medium is had no adverse effects.So can be used as the neutralizer of this disinfectant.
Under test temperature, prove through result of the test, disposable disinfectant stock solution effect 1min to Candida albicans ATCC10231 killing rate logarithm value greater than 3.00, disposable disinfectant 80% dilution effect 1min to Candida albicans ATCC10231 killing rate logarithm value greater than 3.00, disposable disinfectant 60% dilution effect 1min, 3min, 5min to Candida albicans ATCC10231 killing rate logarithm value be respectively 3.17,＞3.00,＞3.00.
Table 4 hand sterilization site test results
The result shows, under 20 ℃ ± 1 ℃ ambient temperature conditions, disposable disinfectant stock solution is to hand disinfecting 1 minute, and hand surface natural bacteria on average killed logarithm value＞1.00.
Table 5 disinfectant toxicology test of the present invention result
The disposable disinfectant of the present invention has different another kind of fungicide active ingredient diphenyl ethers again simultaneously owing to adopted with alcohol radical as a kind of bactericidal activity material, and both complement each other, and make bactericidal effect reach optimal level, accomplish rapidly and efficiently; Because alcohol radical is volatile, need not wipe and do and flushing again, easy to use, because the use of a large amount of safety and sanitation and environment-friendly materials, reduced stimulation to the user, than water base or soap base disinfecting cleaning product have easy to use, safe and actual effect good etc., have many-sided advantage.
Claims (8)
1. disposable sanitizing composition of compound and preparation method, it is characterized in that, comprise following composition and parts by weight proportioning: intercalating agent 0-1 part, aliphatic alcohols 30-70 part, diphenyl ether compound 0-1 part, high polymer 0-5 part, humectant 0-1 part, bleeding agent 0-2 part, spices 0-1 part, deionized water 20-60 part.The state of this disinfectant when not adding pigment is the water white transparency colloid, can flow, and also can not flow, and controlled by viscosity.Colloidal dispersion pH is at 5-8.
2. according to claim 1, the disposable sanitizing composition of compound, it is characterized in that the described intercalating agent that contains is in nitrilotriacetic acid trisodium, Etidronic Acid, ethylenediamine tetra-acetic acid, disodium ethylene diamine tetraacetate, tetrasodium ethylenediamine tetraacetate, ethylenediamine tetra-acetic acid potassium sodium, B,EDTA, amino trimethylene methyl acid phosphate five sodium one or more.
3. according to claim 1, the disposable sanitizing composition of compound, it is characterized in that described diphenyl ether compound is 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether, 2,3,4 '-three chloro-2 '-dihydroxy diphenyl ether, 3,4 '-diamines yl diphenyl ether, 3,4 '-dichloro-diphenyl ether, 4,4 '-wherein one or more of dinitro diphenyl ether.
4. according to claim 1, the disposable sanitizing composition of compound is characterized in that, the described aliphatic alcohols that contains is ethanol, ethylene glycol, propyl alcohol, isopropyl alcohol, propane diols, glycerine, butanols, 1, one or more in the 3-butanediol.
5. according to claim 1, the disposable sanitizing composition of compound, it is characterized in that described high polymer is a Sodium Polyacrylate, PEG2000, PEG3000, polychlorostyrene is for Trimethylamine ethyl-methyl acrylate, the two hard acid esters of PEG6000, methylcellulose, ethyl cellulose, propyl cellulose, cellulose acetate, hydroxymethyl-propyl cellulose, carboxymethyl cellulose, sodium carboxymethylcellulose, sodium carboxymethyl starch, Sodium Hydroxymethyl Stalcs, microcrystalline cellulose, carbopol940, carbopol941, carbopol942, carbopol2020, cellulose acetate-phthalate, wherein one or more of PVPk35.
6. according to claim 1, the disposable sanitizing composition of compound, it is characterized in that described bleeding agent is wherein one or more of diglycerol base list olive grease, azone, octyldodecanol, PEG-(40) rilanit special, crocodile plough oil, N-Methyl pyrrolidone.
7. according to claim 1, the disposable sanitizing composition of compound is characterized in that, described humectant is wherein one or more of monoolein, PEG400, PEG600, protein hydrolysate, several butyl of carboxymethyl-D panthenol, hyaluronic acid.
8. according to claim 1, the disposable sanitizing composition preparation method of compound is characterized in that described preparation method of composition is made up of following steps:
Earlier press 20-60 part deionized water, after the weighing deionized water is joined reactor; According to aliphatic alcohols 30-70 part, add reactor after the weighing under stirring; The intercalating agent of 0-1 part is joined in the reactor, stir intensification and be controlled at 30 ℃-60 ℃; The diphenyl ether compound active component that adds metering 0-1 part while stirring; The 0-5 part high polymer class that adds metering while stirring is stirred well to it is uniformly dispersed fully; Add accurately 0-2 part bleeding agent of metering while stirring, fully stirring is dissolved it fully; Add accurately 0-1 part humectant of metering while stirring, the spices of 0-1 part dissolves it fully and is uniformly dispersed.Backflow 10-20min.When 25 ℃ of solution temperatures, adopt acidometer accurately to monitor, and the pH value of regulator solution is between 5.0-8.0.Final product be transparent, can flow or the immobilising colloidal state preparation that certain viscosity is arranged.
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| CN2010102242420A CN101933513A (en) | 2010-07-13 | 2010-07-13 | Compound washing-free disinfection composition and preparation method thereof |
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| CN2010102242420A CN101933513A (en) | 2010-07-13 | 2010-07-13 | Compound washing-free disinfection composition and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230386A (en) * | 2013-04-18 | 2013-08-07 | 徐州医学院 | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof |
| CN104606119A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Sterilizing and disinfecting waterless hand cleaner |
| CN108956038A (en) * | 2018-07-27 | 2018-12-07 | 山东溢华阀业有限公司 | A kind of standard mouth sealing performance test agent |
| CN109084938A (en) * | 2018-07-27 | 2018-12-25 | 山东溢华阀业有限公司 | A kind of standard mouth leaks hunting agent |
| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
-
2010
- 2010-07-13 CN CN2010102242420A patent/CN101933513A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230386A (en) * | 2013-04-18 | 2013-08-07 | 徐州医学院 | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof |
| CN103230386B (en) * | 2013-04-18 | 2014-12-31 | 徐州医学院 | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof |
| CN104606119A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Sterilizing and disinfecting waterless hand cleaner |
| CN108956038A (en) * | 2018-07-27 | 2018-12-07 | 山东溢华阀业有限公司 | A kind of standard mouth sealing performance test agent |
| CN109084938A (en) * | 2018-07-27 | 2018-12-25 | 山东溢华阀业有限公司 | A kind of standard mouth leaks hunting agent |
| CN116898742A (en) * | 2023-09-13 | 2023-10-20 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
| CN116898742B (en) * | 2023-09-13 | 2023-12-22 | 山东安捷高科消毒科技有限公司 | Hand disinfection gel capable of killing multiple drug-resistant bacteria and inactivating viruses and preparation method thereof |
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