RU2203094C1 - Disinfectant - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: innovation deals with preparations for disinfecting commodities used in taking care for patients, goods of medicinal indication, surfaces, apparatuses, equipment. The suggested preparation contains glutaric aldehyde, quaternary ammonium compound, 1.4-butanediol, nonionic surface-active substance, flavoring and water, at certain quantitative ratios of ingredients. The present disinfectant possesses antimicrobial activity towards gram-positive and gram-negative bacteria. It has got washing, deodorizing properties, does not spoil treated objects, does not decolorize tissues and does not fix organic impurities. EFFECT: higher efficiency of disinfection. 2 cl, 6 tbl

Description

 The invention relates to medicine and relates to a means for disinfection of patient care items, medical devices, as well as surfaces, apparatuses, devices.

 Known disinfectant-washing solution (RU, 2173337 C1), containing in wt. %: polyhexamethylene guanidine hydrochloride 0.025-3; alkylbenzyldimethylammonium chloride 0.006-3; dialdehyde 0.02-3; nonionic surfactant 0.06-4 and the rest is water. The solution is used for disinfection of medical instruments, combined with pre-sterilization treatment, without prior special washing.

 Known disinfectant (RU, 2057796 C1), containing in wt.%: A disinfecting agent based on polyhexamethylene guanidine hydrochloride or phosphate in combination with alkyl dimethylbenzylammonium chloride (catamine AB) in a mass ratio of 1: 1-4, nonionic surfactant up to 25%, perfume, dye and water up to 100%.

 The tool is active against pathogenic microorganisms - Escherichia coli and Pseudomonas aeruginosa, staphylococci, enterococci, fungi of the genus Candido, but not active against viruses.

 The closest in technical essence and the achieved result is a disinfectant (RU, 2145238 C1) containing in wt.%: Alkyldimethylbenzylammonium chloride 25.0-35.0, glutaraldehyde 0.3-0.7, glyoxal 3.5-6 5, a nonionic surfactant 4.0-8.0, ethyl alcohol 6.0-10.0, Trilon B 0.08-0.12, and the rest water.

 The tool has a wide spectrum of action and high activity.

 An object of the present invention is to provide a disinfectant having antimicrobial activity against gram-negative and gram-positive bacteria (including tuberculosis mycobacteria), viruses, pathogenic fungi of the genus Candida and Trichophyton, when they contain a minimally effective concentration of the substance.

To solve this problem, a disinfectant containing glutaraldehyde, alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride, 1,4-butanediol, nonionic surfactant, perfume and water in the following ratio of components, wt.%:
Glutaraldehyde - 1.4-1.8
Alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride - 1.6-2.0
1,4-Butanediol - 1.6-2.2
Nonionic surfactant - 0.4-0.8
Fragrance - 0.01-0.05
Water - Else
Citric acid can be introduced into the composition of the product in an amount providing a pH of 3.5-4.3, and lutenzene or syntanol can be used as a nonionic surfactant.

 The product is a clear, colorless liquid, foaming with shaking.

 The active ingredients of the agent are, for example, 0.9% alkyldimethylbenzylammonium chloride, in the form of a disinfecting substance - catamine AB and 0.8% glutaraldehyde.

 In addition to the active substances, it includes functional additives - 1,4-butanediol, as a nonionic surfactant, for example, lutenzene, citric acid, if necessary, to establish the required pH and perfume.

Cooking example
The disinfectant is manufactured in industrial premises, which must be equipped with general supply and exhaust ventilation. Workers should wear protective clothing, goggles, and rubber gloves. Persons not younger than 18 years old and not suffering from allergic diseases are allowed to work.

 From the containers in which the raw materials are stored, the right amount is cast, using any measuring utensils.

To prepare the product in the amount of one ton, the reactor is poured in any order:
1) 50% aqueous solution of glutaraldehyde - 16 kg;
2) 50% aqueous solution of alkyldimethylbenzylammonium chlorides (catamine AB) - 18 kg;
3) 100% 1,4-butanediol - 20 kg;
4) lutenzene (nonionic surfactant) is heated, converting it from solid to liquid, and weighed 6 kg;
5) fragrance is added in an amount of 0.1 kg;
6) add distilled or drinking water up to 1000 l.

 Then all this is stirred in the reactor for 10 to 30 minutes.

 Then take a small sample of the finished product from the reactor and measure the pH, which should be in the range of 3.5-4.3. If the pH is different, citric acid is added and the pH is measured again.

 Similarly, a preparation is prepared with didecyldimethylammonium chloride and syntanol.

 After achieving the necessary results, the finished product is poured through a dispenser into plastic cans from 1 to 30 l, 200 l barrels or other necessary containers.

 The product is a clear, colorless liquid, foaming with shaking. Contains 0.9% alkyldimethylbenzylammonium chloride (HOUR) and 0.8% glutaraldehyde (GA) as active ingredients, in addition, surfactants, 1,4-butanediol, perfumes, water; pH is 3.5-4.3. The product is packaged in plastic canisters with a capacity of 1, 5, 10, 30, 200 liters.

 The shelf life of the concentrate in the manufacturer’s packaging is 3 years, of working solutions - 14 days, provided that they are stored in closed containers in a dark place.

 The agent (in the form of a concentrate) when introduced into the stomach and when applied to the skin of animals belongs to the 4th class of low-hazard substances according to GOST 12.1.007-76, to the 5th class practically non-toxic when introduced into the abdominal cavity and to the 4th class of low-hazard compounds with a single inhalation exposure ; does not have a local irritant effect on the skin, but causes irritation of the mucous membranes of the eyes.

 Working solutions with potentially dangerous routes of exposure to the body (stomach, skin, with inhalation) belong to the 4th class of low-hazard substances and when introduced into the abdominal cavity are relatively non-toxic (hazard class 6). In case of contact with the skin, solutions in concentrations above 5% upon repeated exposure cause slight skin irritation. If it gets into the eyes, a 10% solution has a moderate, 5 and 2.5% solution - a weak irritant effect on the mucous membranes of the eyes. Vapors of a 0.5% solution with repeated exposure do not cause a sensitizing effect. In the form of an aerosol (the method of "irrigation") has an irritating effect on the upper respiratory tract and belongs to the 3rd class of moderately hazardous substances according to the Classification of the inhalation hazard of disinfectants.

 The product is intended for the disinfection of indoor surfaces, sanitary equipment, patient care items, medical devices (including dental instruments, rigid and flexible endoscopes and their instruments) for infections of bacterial (including tuberculosis), viral and fungal (candidiasis, dermatophytosis ) etiology; carrying out general cleaning in medical institutions.

 Disinfection of objects with various infections with solutions of the drug is carried out according to the modes presented in table. 1-5 (see Appendix).

 When carrying out general cleaning in medical institutions, disinfection is carried out according to the modes presented in table. 6 (see Appendix).

Indoor surfaces (floor walls, doors, etc.), hard furniture, surfaces of appliances, appliances, sanitary equipment (bathtubs, sinks, toilet bowls), rubber mats are wiped with rags moistened with a solution of the agent or irrigated from a hydraulic console, Avtomaksa, spray type "Quasar"), etc. Heavily contaminated surfaces are treated twice. Rubber mats can be decontaminated by immersion. The rate of consumption of the product when wiping is 100 ml / m ^{2 of the} surface, during irrigation - 300 ml / m ² (hydropult, Avtomax), 150 ml / m ² (spray type "Quasar"). After disinfection, the room is ventilated.

 Patient care items are immersed in a solution of the agent or wiped twice with an interval of 15 minutes with a rag moistened with a solution of the agent. At the end of disinfection, they are washed with running water for 5 minutes.

 Disinfection of medical devices is carried out in plastic or enameled (without damaging enamels) containers, which are closed with lids. Products are immersed in a working solution immediately after their use (preventing drying), ensuring the removal of visible contaminants from the surface using tissue napkins; the channels and cavities of the products are thoroughly washed with a solution using a syringe or other device. Detachable products are immersed in the solution disassembled. Products having locking parts are immersed open, having previously made several working movements in the solution for better penetration of the solution into hard-to-reach areas of the products. Used wipes are discarded in a separate container, then disposed of.

 During disinfection, the channels and cavities should be filled (without air jams) with a solution of the product. The level of disinfectant solution above the products must be at least 1 cm.

 When disinfecting endoscopes and instruments for flexible endoscopes, use the processing technology described in the Methodological Recommendations for Cleaning, Disinfection and Sterilization of Endoscopes (15-6 / 33 of 07.17.90) and in the Methodological Recommendations for Disinfection, Presterilization Cleaning and Sterilization medical instruments for flexible endoscopes "(28-6 / 3 of 02/09/08).

 At the end of processing, the product is washed from the product residues for 5 minutes under running water, passing water through the product channels.

 The product has detergent, deodorizing properties, does not spoil processed objects, does not discolor fabrics, and does not fix organic pollution. The product is incompatible with soaps and anionic surfactants.

Claims (2)

1. A disinfectant, characterized in that it contains glutaraldehyde, alkyldimethylbenzylammonium chloride or dedecyldimethylammonium chloride, 1,4-butanediol, a nonionic surfactant, perfume and water in the following ratio of ingredients, wt.%:
Glutaraldehyde - 1.4-1.8
Alkyldimethylbenzylammonium chloride or didecyldimethylammonium chloride - 1.6-2.0
1,4-Butanediol - 1.6-2.2
Nonionic surfactant - 0.4-0.8
Fragrance - 0.01-0.05
Water - Else
2. The tool according to claim 1, characterized in that as a nonionic surfactant use lutenzene or syntanol.  3. The tool according to p. 1, characterized in that it further comprises citric acid to ensure a pH of 3.5-4.3.

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