CN111631996A

CN111631996A - Skin-nourishing hand-washing-free disinfection gel solution and preparation method thereof

Info

Publication number: CN111631996A
Application number: CN202010546498.7A
Authority: CN
Inventors: 徐永福; 苟晓军
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-16
Filing date: 2020-06-16
Publication date: 2020-09-08

Abstract

The invention discloses a skin-nourishing hand-washing-free disinfection gel solution and a preparation method thereof, belonging to the technical field of disinfection gel, and comprising the following components in parts by weight: 0.1-10 parts of sophora flavescens extract, 0.1-1 part of double-chain quaternary ammonium salt disinfectant, 0.01-1 part of single-chain quaternary ammonium salt, 1-20 parts of beta cyclodextrin derivative, 0.1-1 part of nonionic surfactant, 0.5-2 parts of plant gel, 0.5-3 parts of vitamin, 0.0001-0.001 part of essence and 70-95 parts of water. The sterilization gel liquid has wide raw material sources, and through the synergistic effect of various raw materials, the components are mutually matched, so that the sterilization gel liquid has good sterilization effect, has no irritation to skin, can kill pathogenic bacteria, viruses and molds, nourish the skin, is suitable for hand sterilization in the high-incidence period of infectious diseases, is wash-free for the skin, and can be used for surgical hand sterilization, sanitary hand sterilization and skin health care, and prevention, treatment and removal of psoriasis.

Description

Skin-nourishing hand-washing-free disinfection gel solution and preparation method thereof

Technical Field

The invention belongs to the technical field of disinfection gel, and particularly relates to a skin-nourishing hand-washing-free disinfection gel liquid and a preparation method thereof.

Background

The disinfectant commonly used in the disinfectant gel comprises oxidative disinfectant, alcohol disinfectant, surfactant disinfectant and biological disinfectant, wherein the oxidative disinfectant comprises peroxide disinfectant, chlorine-containing disinfectant, iodine-containing disinfectant and the like, and the alcohol disinfectant comprises ethanol and isopropanol. The surfactant disinfectant includes chlorhexidine and quaternary ammonium salt disinfectant, and the biological disinfectant is mainly live microorganism. At present, when volatile alcohols are used as a disinfectant and a solvent, in consideration of the requirements of safety and non-toxicity, ethanol or isopropanol is generally used, has dehydration effect and can solidify protein to cause the death of pathogenic bacteria, has outstanding effect of inhibiting the activity of gram-negative bacteria, gram-positive bacteria, envelope viruses and various fungi in vitro, can kill bacterial propagules, has stronger effect of killing most lipophilic viruses, is more commonly used in the field of hand disinfection compared with isopropanol, has strong pungent smell when the content of ethanol is too high, is difficult to be accepted by consumers, has poor sterilization effect when the content of ethanol is too low, has optimal ethanol disinfection concentration of 75 percent, but has larger irritation to skin, and if alcohol disinfectant is frequently used for hand washing disinfection, the skin can be dried due to degreasing, Coarse, so ethanol needs to be used in combination with other components.

People can contact various infectious bacteria, particularly viruses in daily life, and the conventional disinfectant, such as 75% alcohol disinfectant, chlorine-containing disinfectant, iodine-containing disinfectant and the like, has limited effect on the viruses because of simple structure, the protein shell and the internal genetic material and no cell structure, and the disinfectant has large irritation on skin and long action time and is not suitable to be taken as the conventional skin or hand disinfectant carried with people. To this end, modern disinfectants are endowed with new requirements: broad spectrum killing bacteria and viruses, quick response, high efficiency, long-acting sterilization and bacteriostasis, no toxicity and no stimulation to skin and the like. Highly pathogenic viruses such as SARS-associated coronavirus, hepatitis B virus, HIV and the like threaten human life and health, many diseases are related to pathogenic microorganism infection, hands are an important way for virus and germ transmission, hand disinfection can prevent the transmission of viruses and germs, human health is maintained, and hand-washing-free disinfection is required to be more effective and more convenient. At present, the hand-washing-free disinfectant is mainly 75% of ethanol and 75% of ethanol gel, the 75% of ethanol can effectively kill germs and viruses, but the disinfectant has flammable potential safety hazards, is inconvenient to carry, is easy to cause dryness after slight damage to hands, and is not suitable for long-term use; 84 disinfectant and peracetic acid have killing effect on viruses, but have corrosivity on skin and cannot be used for skin disinfection, and other disinfection products have no definite killing effect on viruses; in order to bring convenience to health and travel of people, the skin-nourishing and hand-washing-free disinfection gel solution needs to be invented for surgical hand disinfection, sanitary hand disinfection and skin health care, preventing and treating psoriasis and removing peculiar (smelly) smell. Therefore, how to achieve the aims of reducing the side effect of the disinfectant while achieving high sterilization rate, simultaneously ensuring that a consumer does not feel sticky, has comfortable smell and good skin care effect, and needs to have wide sterilization spectrum, good sterilization effect, fresh hand feeling and small irritation, which is a problem to be solved urgently.

Disclosure of Invention

The invention aims to solve the technical problem of providing a skin-nourishing hand-free disinfection gel solution, and solves the problems in the background technology.

It is another object of the present invention to provide a method for preparing a hand sanitizing gel.

In order to achieve the above purpose, the invention adopts the technical scheme that: a skin-nourishing hand-washing-free disinfection gel solution is composed of the following components in parts by weight:

0.1-10 parts of sophora flavescens extract, 0.1-1 part of double-chain quaternary ammonium salt disinfectant, 0.01-1 part of single-chain quaternary ammonium salt, 1-20 parts of beta cyclodextrin derivative, 0.1-1 part of nonionic surfactant, 0.5-2 parts of plant gel, 0.5-3 parts of vitamin, 0.0001-0.001 part of essence and 70-95 parts of water.

Furthermore, the double-chain quaternary ammonium salt compound has a hydrophilic group and two lipophilic groups, can change the permeability of cells, and can cause thalli to swell and break due to water entering; has good surface activity, is highly gathered on the surface of the thallus and influences the metabolism of the bacteria; denaturing the protein; the enzyme system in the inactivated bacteria cell interferes protein metabolism to cause the final death of microorganisms, and the hospital disinfection technical specification is clear, namely the double-chain quaternary ammonium salt can effectively kill 48 viruses including HIV and avian influenza viruses. The double-chain quaternary ammonium salt compound and the single-chain quaternary ammonium salt compound enhance the sterilization effect and can effectively kill SARS related coronavirus. The matrine extracted from radix Sophorae Flavescentis is effective in inhibiting bacteria and fungi; the complex disinfectant of the sophora flavescens extract, the double-chain quaternary ammonium salt and the single-chain quaternary ammonium salt is combined with the betacyclodextrin derivative to form an inclusion compound, so that the bactericidal effect can be increased, the irritation to the skin can be reduced, and the betacyclodextrin derivative has the function of removing peculiar smell (deodorization); the picrine, the double-chain quaternary ammonium salt, the single-chain quaternary ammonium salt chain composite disinfectant, the betacyclodextrin derivative and the plant gel form an aqueous gel system, a layer of drug slow-release protective film can be formed on the surface of skin, the slow-release effect is achieved, the bacteriostatic effect is improved, the irritation to the skin is reduced, and the vitamins can provide nutrition for the skin, nourish the skin, prevent and treat psoriasis and remove foreign (odor) taste.

As a further scheme of the embodiment of the invention: the double-chain quaternary ammonium salt comprises at least one of double-C alkyl quaternary ammonium bromide salt and double-C alkyl quaternary ammonium chloride salt.

As a further scheme of the embodiment of the invention: the single-chain quaternary ammonium salt comprises at least one of dodecyl trimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, octadecyl dimethyl benzyl ammonium chloride, cyano quaternary ammonium salt, polyazacyclo quaternary ammonium salt and polyquaternary ammonium salt.

As a further scheme of the embodiment of the invention: the betacyclodextrin derivative comprises at least one of hydroxypropyl betacyclodextrin, sulfobutyl betacyclodextrin, methyl betacyclodextrin and hydroxybutyl betacyclodextrin.

As a further scheme of the embodiment of the invention: the vitamins include vitamin E and vitamin B6.

As a further scheme of the embodiment of the invention: the nonionic surfactant comprises at least one of fatty alcohol-polyoxyethylene ether, alkylphenol ethoxylate and fatty acid-polyoxyethylene ester.

As a further scheme of the embodiment of the invention: the plant gel comprises one or more of guar gum, peach gum, chitosan, hydroxypropyl methylcellulose, polyvinyl alcohol, gum arabic and quaternary ammonium salt guar gum.

As a further scheme of the embodiment of the invention: the preparation method of the sophora flavescens extract comprises the following steps: adding into deionized water 5-8 times its weight, decocting at 85-96 deg.C for 2-3 times, filtering, mixing filtrates, and separating the extract with ion exchange resin.

The preparation method of the skin-nourishing hand-washing-free disinfection gel liquid comprises the following steps:

1) mixing the raw materials and stirring uniformly;

2) standing for 50-80 minutes after the step 1);

3) and 2) obtaining the skin-nourishing hand-washing-free disinfection gel liquid.

The embodiment of the invention has the beneficial effects that:

the skin-nourishing hand-washing-free disinfection gel liquid has wide raw material sources, and the prepared finished product has the effects of killing viruses, germs and mildew on the surface of skin by the synergistic effect of various raw materials and the mutual matching of the components, has the effects of nourishing the skin, preventing and treating tinea and removing peculiar (smelly) taste, and has wide application prospects. The hand sanitizer is beneficial to protecting skin, protects a sebum membrane from losing moisture of the skin after hand disinfection, plays a role in protecting hands while effectively killing germs and nosocomial infection common bacteria, is convenient, quick, efficient, green, environment-friendly and healthy; the invention adopts raw materials with high degradation degree and high safety, and is green and environment-friendly; the preparation method of the skin-nourishing hand-free disinfection gel liquid is simple and easy to operate, and has the advantages of low price of used raw materials and low production cost.

Detailed Description

The technical solution of the present patent will be described in further detail with reference to the following embodiments.

Example 1

The skin-nourishing hand-washing-free disinfection gel solution comprises the following components in parts by weight:

1 kg of radix sophorae flavescentis extract, 0.1 kg of di-C alkyl quaternary ammonium bromide disinfectant, 0.1 kg of dodecyl trimethyl ammonium chloride disinfectant, 1 kg of hydroxypropyl beta cyclodextrin, 0.5 kg of guar gum, 0.5 kg of fatty alcohol polyoxyethylene ether, 0.2 kg of vitamin E, 60 kg of vitamin B, 0.0001 kg of essence and 70 kg of water, wherein the radix sophorae flavescentis extract has a sterilization effect and can kill bacteria and fungi, the di-C alkyl quaternary ammonium bromide and dodecyl trimethyl ammonium chloride disinfectant have a virus killing effect, the combination of the radix sophorae flavescentis extract, the di-C alkyl quaternary ammonium bromide and dodecyl trimethyl ammonium chloride disinfectant is more effective on bacteria, fungi and viruses, and the bacteriostasis rate can reach more than 99.9%; the sophora flavescens extract, the di-C alkyl quaternary ammonium bromide, the dodecyl trimethyl ammonium chloride disinfectant and the hydroxypropyl betacyclodextrin are combined to form an inclusion compound, so that the bactericidal and virucidal effects can be improved, the irritation to the skin can be reduced, and the hydroxypropyl betacyclodextrin has the function of removing odor; the sophora flavescens extract, the di-C alkyl quaternary ammonium bromide, the dodecyl trimethyl ammonium chloride disinfectant, the hydroxypropyl betadex and the plant gel form an aqueous gel system, a layer of drug slow-release protective film can be formed on the surface of skin, the slow-release sterilization and virus killing effects are achieved, the irritation to the skin is reduced, the vitamins can provide nutrition for the skin and nourish the skin, and the preparation method of the sophora flavescens extract comprises the following steps: adding radix Sophorae Flavescentis into deionized water 5-8 times its weight, decocting at 85-96 deg.C for 2-3 times, filtering, mixing filtrates, and separating the extract with ion exchange resin.

The preparation method of the skin nourishing and hand washing-free disinfection gel liquid comprises the following steps:

1) mixing the raw materials and stirring uniformly;

2) standing for 50-80 minutes after the step 1);

Example 2

3.8 kg of sophora flavescens extract, 0.6 kg of di-C alkyl quaternary ammonium chloride, 0.4 kg of dodecyl trimethyl ammonium chloride, 8.6 kg of hydroxypropyl betacyclodextrin, 0.1 kg of alkylphenol polyoxyethylene, 1 kg of quaternary ammonium guar gum, 1.00 kg of vitamin E, 60.5 kg of VB, 0.0002 kg of essence and 78 kg of water, wherein the sophora flavescens extract has the bactericidal effect and can kill bacteria and fungi, the di-C alkyl quaternary ammonium chloride and the dodecyl trimethyl ammonium chloride have the effect of killing viruses, the combination of the sophora flavescens extract, the di-C alkyl quaternary ammonium chloride and the dodecyl trimethyl ammonium chloride has more effective bactericidal effect on bacteria and fungi, and the bactericidal rate can reach more than 99.99%; the sophora flavescens extract, the di-C alkyl quaternary ammonium chloride salt, the dodecyl trimethyl ammonium chloride and the hydroxypropyl betacyclodextrin are combined to form an inclusion compound, so that the bactericidal effect can be improved, the irritation to the skin can be reduced, and the hydroxypropyl betacyclodextrin has the function of removing odor; the sophora flavescens extract, the di-C alkyl quaternary ammonium chloride salt, the dodecyl trimethyl ammonium chloride, the quaternary ammonium salt guar gum and the hydroxypropyl betadex form an aqueous gel system, a layer of drug slow-release protective film can be formed on the surface of skin, the slow-release effect is achieved, the sterilization effect is improved, the irritation to the skin is reduced, and vitamins and nutrition can be provided for the skin to nourish the skin.

1) mixing and stirring the raw materials uniformly at 25 ℃;

2) standing for 60 minutes after the step 1);

The preparation method of the sophora flavescens extract comprises the following steps:

1) adding radix Sophorae Flavescentis into 5-8 times of deionized water, and decocting at 85-96 deg.C for 2-3 times;

2) step 1) post-filtration and combining the filtrates;

3) the extract obtained after the step 2) and separated and extracted by ion exchange resin is the skin nourishing hand-free disinfection gel liquid.

Test examples

A skin-nourishing hand-washing-free disinfection gel liquid using effect test comprises the following steps:

by adopting a suspension quantitative method, according to a method in disinfection technical specification (2002 edition) issued by the Ministry of public health of the people's republic of China, the skin-nourishing hand-washing-free disinfection gel liquid is used for acting for 0.5min at the temperature of 20 ℃ on staphylococcus aureus, escherichia coli and candida albicans, and the test is repeated for three times.

Hand disinfection field test the gel solution for skin nourishing and hand free disinfection was tested on the hand disinfection field according to the method in disinfection technical Specification (2002 edition) issued by the Ministry of health of the people's republic of China. Before disinfection, the two hands of the testee are rubbed fully, the left fingers of the testee are closed, the testee is soaked in a test tube containing 10mL of diluent by using a sterile cotton swab, after the test tube is wrung on the tube wall, the sterile cotton swab is rubbed three times back and forth from the fingertips to the finger roots of the five finger bends, and the cotton swab is rotated once every time the sterile cotton swab is rubbed. After sampling, cutting a sampling end of a cotton swab into a diluent tube by using scissors in a sterile operation mode to serve as a positive control group; then, disinfecting the right hand for 1min by adopting skin-nourishing hand-washing-free disinfection gel liquid, replacing diluent with neutralization liquid after disinfection, sampling natural bacteria remained on the right hand of the subject once by the same method as a positive control group, taking the natural bacteria as an experimental group, culturing after sampling, and culturing at 37 ℃ for 48h to observe the final result.

The following table shows: sterilizing effects of the embodiments

Item	Staphylococcus aureus	Escherichia coli	Candida albicans	Bacillus subtilis	Poliovirus type I
						Example 1	>5.00	>5.00	>4.00	>5.00	>4.00
Example 2	>5.00	>5.00	>4.00	>5.00	>4.00

The table shows that the skin-nourishing hand-washing-free disinfection gel liquid prepared by the invention has a good effect of killing microorganisms, and meanwhile, the skin-nourishing hand-washing-free disinfection gel liquid prepared by the invention does not cause hand chap and allergy of medical care personnel in the using process and has excellent quality.

The present invention is not limited to the above embodiments, and those skilled in the art can implement the present invention in other embodiments according to the disclosure of the present invention, or make simple changes or modifications on the design structure and idea of the present invention, and fall into the protection scope of the present invention.

Claims

1. The skin-nourishing hand-washing-free disinfection gel liquid is characterized in that:

comprises the following components in parts by weight:

2. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the double-chain quaternary ammonium salt of the no-clean hand disinfection gel liquid with the function of nourishing the skin comprises at least one of double-C alkyl quaternary ammonium bromide salt and double-C alkyl quaternary ammonium chloride salt.

3. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the single-chain quaternary ammonium salt of the skin-nourishing no-wash hand disinfection gel solution comprises at least one of dodecyl trimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium bromide, octadecyl dimethyl benzyl ammonium chloride, cyano quaternary ammonium salt, polyazacyclo quaternary ammonium salt and polyquaternary ammonium salt.

4. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the skin-nourishing no-wash hand disinfection gel liquid betacyclodextrin derivative contains at least one of hydroxypropyl betacyclodextrin, sulfobutyl betacyclodextrin, methyl betacyclodextrin and hydroxybutyl betacyclodextrin.

5. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the disinfectant gel solution vitamin with the function of nourishing the skin comprises vitamin E and vitamin B6.

6. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the non-ionic surfactant of the gel liquid for washing-free hand disinfection with skin nourishing function comprises at least one of fatty alcohol polyoxyethylene ether, alkylphenol polyoxyethylene ether and fatty acid polyoxyethylene ester.

7. The gel liquid for nourishing skin, no-washing and disinfecting hands as claimed in claim 1 or 3, wherein: the non-washing hand disinfection gel liquid plant gel capable of nourishing skin comprises one or a mixture of more of guar gum, peach gum, chitosan, hydroxypropyl methylcellulose, polyvinyl alcohol, Arabic gum and quaternary ammonium salt guar gum.

8. The gel liquid for nourishing skin and disinfecting hands without washing as claimed in claim 1, wherein: the preparation method of the skin-nourishing washing-free disinfection gel liquid plant gel bitter extract comprises the following steps: adding into deionized water 5-8 times its weight, decocting at 85-96 deg.C for 2-3 times, filtering, mixing filtrates, and separating the extract with ion exchange resin.

9. The method for preparing the gel liquid for nourishing skin, washing free and disinfecting hands as claimed in claim 1 or 8, wherein:

the method comprises the following steps:

1) mixing the raw materials and stirring uniformly;

2) standing for 50-80 minutes after the step 1);