CN112274561A - Disinfectant containing camphor oil component and preparation method thereof - Google Patents
Disinfectant containing camphor oil component and preparation method thereof Download PDFInfo
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- CN112274561A CN112274561A CN202011278781.2A CN202011278781A CN112274561A CN 112274561 A CN112274561 A CN 112274561A CN 202011278781 A CN202011278781 A CN 202011278781A CN 112274561 A CN112274561 A CN 112274561A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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Abstract
The invention discloses a disinfectant containing camphor oil components and a preparation method thereof, wherein the disinfectant comprises the following components: polyhexamethylene biguanide, chlorhexidine acetate, glycerol, natural essence, alpha-pinene, gamma-terpinene and sassafras hydrolat. The components of alpha-pinene and gamma-pinene extracted from camphor leaf volatile oil added into the disinfectant have good antibacterial activity, are non-toxic and harmless, have small irritation to skin, and ensure safety and timeliness in use; the components also comprise polyhexamethylene biguanide and chlorhexidine acetate, and the components contain various sterilization components, so that the antibacterial spectrum of the disinfectant can be expanded, the generation of drug resistance of microorganisms is avoided, and the service life of the disinfectant is prolonged.
Description
Technical Field
The invention relates to the field of disinfectant, in particular to a disinfectant containing camphor oil and a preparation method thereof.
Background
At present, eighty percent of disinfectant products in the market are produced by taking alcohol, isopropanol, chlorhexidine acetate or other sterilizing components as raw materials, and although the disinfectant can achieve the effect of quick and comprehensive sterilization, the defects are obvious. Some people are allergic to alcohol and cannot use the alcohol; prolonged exposure to alcohol can cause the skin to lose elasticity and luster; alcohol is flammable and has poor safety; the smell is large, and the use experience is poor; more importantly, the alcohol volatilizes quickly, the sterilization time is short, and the bacteriostatic action of the disinfectant is difficult to maintain.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a disinfectant containing camphor oil and a preparation method thereof.
The invention is realized by the following technical scheme:
the disinfectant containing camphor oil components comprises the following components:
polyhexamethylene biguanide, chlorhexidine acetate, glycerol, natural essence, alpha-pinene, gamma-terpinene and sassafras hydrolat.
The main technical difference between the scheme and the conventional disinfectant is as follows: the alpha-pinene and gamma-terpinene extracted from the camphor leaf volatile oil are used for replacing alcohol, and the alpha-pinene and the gamma-terpinene have various biological activities, particularly good antibacterial activity, are non-toxic and harmless, have small irritation to skin and ensure the safety in use. Meanwhile, the problems that alcohol volatilizes quickly, the sterilization time efficiency is short, and the bacteriostatic action of the disinfectant is difficult to maintain can be solved. In addition, the alpha-pinene and the gamma-terpinene are extracted from the camphor leaf volatile oil, and the production raw materials are green and environment-friendly.
The components also comprise polyhexamethylene biguanide and chlorhexidine acetate. Polyhexamethylene biguanide as an environment-friendly degradable high-molecular polymer disinfectant has higher safety, mildness and bactericidal performance compared with other salts, but has higher cost; the chlorhexidine acetate has the main functions of disinfection and sterilization, the mechanism is to destroy the cell wall plasma membrane of pathogenic microorganisms and rapidly kill bacteria, fungi, viruses and the like, and the chlorhexidine acetate has the advantages of low toxicity, small toxic and side effects, no local stimulation, extremely rare anaphylactic reaction and the like. The components are taken as main sterilization components to carry out reasonable compounding on the disinfectant, so that the consumption of the polyhexamethylene biguanide can be reduced, certain cost is saved, the antibacterial spectrum of the disinfectant can be expanded, the generation of drug resistance of microorganisms is avoided, and the service life of the disinfectant is prolonged.
The camphor wood hydrosol is a condensation byproduct generated in the process of extracting camphor wood oil by using water vapor, and contains a small amount of eucalyptus oil and other essential oil components. The sassafras purified water can replace deionized water to be used, and plays a certain role in disinfection and sterilization. The disinfectant added in the scheme can reduce the usage amount of alpha-pinene and gamma-terpinene to a certain extent, thereby playing a role in reducing the production cost.
And natural essence is added for blending, so that the use experience of a user can be improved.
Further, the components in parts by weight are as follows:
preferably, the mass parts of the components can be set as follows: 0.1 part of polyhexamethylene biguanide, 0.2 part of chlorhexidine acetate, 0.5 part of glycerol, 0.2 part of natural essence, 0.2 part of alpha-pinene, 0.1 part of gamma-terpinene and 98.7 parts of camphor-type hydrosol.
Wherein the natural essence can be one or more of rose essential oil, lavender essential oil, bergamot essential oil, sweet osmanthus essential oil and sweet orange essential oil.
The invention also provides a preparation method of the disinfectant containing camphor oil components, which comprises the following steps:
(1) preparing materials: weighing polyhexamethylene biguanide, chlorhexidine acetate, glycerol, natural essence, alpha-pinene, gamma-terpinene and sassafras hydrolat for later use;
(2) placing the safrole hydrosol and the glycerol into a stirrer, adjusting the temperature in the stirrer to 50 ℃, and mixing and stirring;
(3) adding polyhexamethylene biguanide and chlorhexidine acetate, and stirring;
(4) and (3) continuously and slowly stirring the substances in the stirrer, adding natural essence, alpha-pinene and gamma-terpinene into the mixture in the process, simultaneously stirring the mixture for 5 minutes, cooling the mixture to 20-25 ℃, standing the mixture for 6 hours, and subpackaging the mixture in bottles.
Preferably, the stirring time in step (2) is 5 minutes, and the stirring time in step (3) is 10 minutes.
Compared with the prior art, the invention has the following advantages and beneficial effects:
1. the invention provides a disinfectant containing camphor oil components, which is added with alpha-pinene and gamma-terpinene components extracted from camphor leaf volatile oil, has better antibacterial activity, is non-toxic and harmless, has small irritation to skin and ensures the safety in use; meanwhile, the problems that alcohol is volatilized quickly, the sterilization time is short, and the bacteriostatic action of the disinfectant is difficult to maintain are solved; in addition, the alpha-pinene and the gamma-terpinene are extracted from the camphor leaf volatile oil, and the production raw materials are green and environment-friendly.
2. The invention provides a disinfectant containing camphor oil, which is prepared by reasonably compounding polyhexamethylene biguanide, chlorhexidine acetate, alpha-pinene and gamma-terpinene serving as main sterilization components, so that the consumption of the polyhexamethylene biguanide can be reduced, a certain cost can be saved, the antibacterial spectrum of the disinfectant can be expanded, the generation of drug resistance of microorganisms can be avoided, and the service life of the disinfectant can be prolonged.
3. The invention provides a disinfectant containing camphor oil components, which uses camphor oil hydrosol to replace deionized water, and reduces the usage amount of alpha-pinene and gamma-terpinene to a certain extent, thereby reducing the effect of production cost.
Detailed Description
The present invention is further described in detail below with reference to examples, which are provided to assist those skilled in the art in further understanding the present invention, but are not intended to limit the present invention in any way. It should be noted that various changes and modifications can be made by those skilled in the art without departing from the spirit of the invention, and these changes and modifications are all within the scope of the invention.
Example 1:
a disinfectant containing camphor oil is prepared by the following processes:
(1) preparing materials: weighing 0.1 part of polyhexamethylene biguanide, 0.2 part of chlorhexidine acetate, 0.5 part of glycerol, 0.2 part of natural essence, 0.2 part of alpha-pinene, 0.1 part of gamma-terpinene and 98.7 parts of camphor pure water according to the mass parts for later use;
(2) placing the safrole hydrosol and the glycerol into a stirrer, adjusting the temperature in the stirrer to 50 ℃, and mixing and stirring for 5 minutes;
(3) adding polyhexamethylene biguanide and chlorhexidine acetate, and stirring for 10 minutes;
(4) and (3) continuously and slowly stirring the substances in the stirrer, adding natural essence, alpha-pinene and gamma-terpinene into the mixture in the process, simultaneously stirring the mixture for 5 minutes, cooling the mixture to 20-25 ℃, standing the mixture for 6 hours, and subpackaging the mixture in bottles.
Wherein the natural essence can be one or more of rose essential oil, lavender essential oil, bergamot essential oil, sweet osmanthus essential oil and sweet orange essential oil.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (6)
1. The disinfectant containing camphor oil is characterized by comprising the following components:
polyhexamethylene biguanide, chlorhexidine acetate, glycerol, natural essence, alpha-pinene, gamma-terpinene and sassafras hydrolat.
3. the disinfectant liquid as claimed in claim 2, wherein said disinfectant liquid comprises polyhexamethylene biguanide 0.1 part, chlorhexidine acetate 0.2 part, glycerol 0.5 part, natural essence 0.2 part, α -pinene 0.2 part, γ -terpinene 0.1 part, and safrole 98.7 parts.
4. The disinfectant liquid containing camphor oil components as claimed in claim 1, wherein said natural essence is one or more of rose essential oil, lavender essential oil, bergamot essential oil, sweet osmanthus essential oil, and sweet orange essential oil.
5. The method for preparing disinfectant liquid containing camphor oil components as claimed in any one of claims 1 to 4, comprising the steps of:
(1) preparing materials: weighing polyhexamethylene biguanide, chlorhexidine acetate, glycerol, natural essence, alpha-pinene, gamma-terpinene and sassafras hydrolat for later use;
(2) placing the safrole hydrosol and the glycerol into a stirrer, adjusting the temperature in the stirrer to 50 ℃, and mixing and stirring;
(3) adding polyhexamethylene biguanide and chlorhexidine acetate, and stirring;
(4) and (3) continuously and slowly stirring the substances in the stirrer, adding natural essence, alpha-pinene and gamma-terpinene into the mixture in the process, simultaneously stirring the mixture for 5 minutes, cooling the mixture to 20-25 ℃, standing the mixture for 6 hours, and subpackaging the mixture in bottles.
6. The method for preparing disinfectant liquid containing camphor oil components as set forth in claim 5, wherein the stirring time in step (2) is 5 minutes, and the stirring time in step (3) is 10 minutes.
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CN202011278781.2A CN112274561A (en) | 2020-11-16 | 2020-11-16 | Disinfectant containing camphor oil component and preparation method thereof |
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CN202011278781.2A CN112274561A (en) | 2020-11-16 | 2020-11-16 | Disinfectant containing camphor oil component and preparation method thereof |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110583710A (en) * | 2019-10-08 | 2019-12-20 | 宜宾学院 | Multifunctional bacteriostatic composition and preparation method and application thereof |
CN111202088A (en) * | 2020-03-06 | 2020-05-29 | 吉林云飞医药有限公司 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
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2020
- 2020-11-16 CN CN202011278781.2A patent/CN112274561A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110583710A (en) * | 2019-10-08 | 2019-12-20 | 宜宾学院 | Multifunctional bacteriostatic composition and preparation method and application thereof |
CN111202088A (en) * | 2020-03-06 | 2020-05-29 | 吉林云飞医药有限公司 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
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Application publication date: 20210129 |