CN101926819A - Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof - Google Patents
Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof Download PDFInfo
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- CN101926819A CN101926819A CN2009100536234A CN200910053623A CN101926819A CN 101926819 A CN101926819 A CN 101926819A CN 2009100536234 A CN2009100536234 A CN 2009100536234A CN 200910053623 A CN200910053623 A CN 200910053623A CN 101926819 A CN101926819 A CN 101926819A
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- polyhexamethylene guanidine
- iodine
- disinfector
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- complexing
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Abstract
The invention relates to a compound polyhexamethylene guanidine complexing iodine disinfector and a preparation method thereof. The compound polyhexamethylene guanidine complexing iodine disinfector comprises the following components in percentage by mass: 0.1-0.5 percent of polyhexamethylene guanidine, 0.5-5 percent of PVP-I (polyvinylpyrrolidone iodine), 30-70 percent of ethanol, 0.1-1 percent of non-ionic surface active agent, 0.5-3 percent of skin-protecting agent, 0.05-0.2 percent of citric acid and the balance of water. The preparation method of the compound polyhexamethylene guanidine complexing iodine disinfector comprises the following steps of: adding polyvinylpyrrolidone iodine into the water according to the content and the components, and stirring the mixture to dissolve; sequentially adding the non-ionic surface active agent, the skin-protecting agent and the citric acid, and stirring the mixture to dissolve; adding and stirring ethanol to the mixture uniformly; and adding and stirring polyhexamethylene guanidine to the mixture uniformly to obtain the compound polyhexamethylene guanidine complexing iodine disinfector. The compound polyhexamethylene guanidine complexing iodine disinfector has the characteristics of stable characteristics, quick and lasting sterilization function, low simulation to skins, quick drying and convenient use.
Description
Technical field
The present invention relates to disinfectant, relate in particular to a kind of compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof.
Background technology
Polyhexamethylene guanidine is a kind of wide spectrum, quick-acting bactericide, cell wall by acting on antibacterial and fungus and cytoplasmic film system, combine with the fatty acid in the cell membrane phospholipid, puncture their cytoplasma membrane rapidly, break through the core of pathogenic bacteria cell, make the intravital living matter outflow of pathogenic bacteria, thereby reach bactericidal effect.Unite use with other antibacterial, can bring into play splendid Disinfection Effect.Because polyhexamethylene guanidine has a kind of unspecific sterilization mode, so antibacterial is very little to the probability that it develops immunity to drugs.
Iodine is a kind of disinfectant commonly used, destroys the layer structure of antibacterial by iodination.Povidon iodine (PVP-I) is the complex that iodine and macromolecular compound polyvinylpyrrolidone form, and can continue to discharge free-iodine, the performance long-acting, but the slow-footed shortcoming of onset is arranged.
Ethanol is a kind of disinfectant commonly used, and its bactericidal action is because their effects of to proteinic degeneration ability, being characterized in are rapid, but is easy to generate fastbacteria.
Summary of the invention
The present invention is intended to overcome the shortcoming of folk prescription disinfectant, and the compound disinfectant that utilizes multicomponent to form enlarges the antimicrobial spectrum scope, prevents that fastbacteria from producing, and brings into play rapid-curing cutback, quick-acting, long lasting characteristics simultaneously.
A kind of compound polyhexamethylene guanidine complexing iodine disinfector, it comprises each component of following each percetage by weight:
Polyhexamethylene guanidine, 0.1-0.5;
Povidon iodine (PVP-I), 0.5-5;
Ethanol, 30-70;
Non-ionic surface active agent, 0.1-1;
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Water, surplus.
Described disinfectant, described non-ionic surface active agent are one or more of fatty alcohol-polyoxyethylene ether, alkylphenol polyoxyethylene, polyoxyethylene sorbitan ester.
Described disinfectant, described skin protectant can be that glycerol or Polyethylene Glycol or both share.
The preparation method of described disinfectant is: by described content and component, povidon iodine is added to the water stirring and dissolving; Add non-ionic surface active agent, skin protectant, citric acid successively, stirring and dissolving; Add ethanol, mix; Add the polyhexamethylene guanidine again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
The present invention forms compound disinfectant with polyhexamethylene guanidine, povidon iodine, ethanol use in conjunction, enlarges the antimicrobial spectrum scope, prevents that fastbacteria from producing, and has rapid-curing cutback, quick-acting, long lasting characteristics simultaneously.Non-ionic surface active agent has solubilization to multicomponent in the prescription, also is beneficial to the cleaning after disinfectant is used.Glycerol and Polyethylene Glycol have good moisture-keeping function and lubricity as skin protectant.Citric acid is kept the faintly acid of disinfectant, alleviates the zest of disinfectant to skin and mucosa, improves the comfort of skin.
The specific embodiment
Below, in conjunction with specific embodiments, further specify the present invention:
A kind of compound polyhexamethylene guanidine complexing iodine disinfector, it comprises each component of following each percetage by weight:
Polyhexamethylene guanidine, 0.1-0.5;
Povidon iodine (PVP-I), 0.5-5;
Ethanol, 30-70;
Non-ionic surface active agent, 0.1-1;
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Water, surplus.
Described disinfectant, one or more in described non-ionic surface active agent preferred fat polyoxyethylenated alcohol, alkylphenol polyoxyethylene, the polyoxyethylene sorbitan ester.
Described disinfectant, described skin protectant can be that glycerol or Polyethylene Glycol or both share.
The preparation method of described disinfectant is: by described content and component, povidon iodine is added to the water stirring and dissolving; Add non-ionic surface active agent, skin protectant, citric acid successively, stirring and dissolving; Add ethanol, mix; Add the polyhexamethylene guanidine again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
Embodiment 1
Povidon iodine 10 grams are joined in the 271 gram water stirring and dissolving; Add fatty alcohol-polyoxyethylene ether (Aeo9) 3 grams, glycerol 10 grams, citric acid 1 gram successively, stirring and dissolving; Add ethanol 700 grams, mix; Add polyhexamethylene guanidine 5 grams again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
Embodiment 2
Povidon iodine 20 grams are joined in the 351 gram water stirring and dissolving; Add NPE-10 (TX-10) 5 grams, glycerol 10 grams, Polyethylene Glycol 10 grams, citric acid 1 gram successively, stirring and dissolving; Add ethanol 600 grams, mix; Add polyhexamethylene guanidine 3 grams again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
Embodiment 3
Povidon iodine 50 grams are joined in the 576 gram water stirring and dissolving; Add polyoxyethylene dehydration Pyrusussuriensis list oleic acid alcohol ester (Tween80) 10 grams, Polyethylene Glycol 10 grams, citric acid 2 grams successively, stirring and dissolving; Add ethanol 350 grams, mix; Add polyhexamethylene guanidine 2 grams again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
The various embodiments described above disinfectant, under 19-21 ℃ of condition, effect 1min on average kills logarithm value all＞5.00 to staphylococcus aureus, escherichia coli, Candida albicans, bacillus pyocyaneus.The accelerated stability test result shows that 37 ℃ of constant temperature were deposited 90 days, and polyhexamethylene guanidine content rate of descent is less than 3%, and the available iodine content rate of descent is less than 8%, and the ethanol content rate of descent is less than 6%.Intact skin irritant test result is a nonirritant.
As the compound polyhexamethylene guanidine complexing iodine disinfector stable in properties that above-mentioned embodiment makes, bactericidal effect is good, and is low to skin irritation, and has quick-acting holding and imitate and with the back characteristics of rapid-curing cutback, easy to use.
Claims (4)
1. compound polyhexamethylene guanidine complexing iodine disinfector, it comprises each component of following each percetage by weight:
Polyhexamethylene guanidine, 0.1-0.5;
Povidon iodine PVP-I, 0.5-5;
Ethanol, 30-70;
Non-ionic surface active agent, 0.1-1;
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Water, surplus.
2. disinfectant according to claim 1 is characterized in that, described non-ionic surface active agent be fatty alcohol-polyoxyethylene ether, alkylphenol polyoxyethylene or polyoxyethylene sorbitan ester in one or more.
3. disinfectant according to claim 1 is characterized in that, described skin protectant is that glycerol or Polyethylene Glycol or both share.
4. the preparation method according to the described disinfectant of claim 1 to 3 is: by described content and component, povidon iodine is added to the water stirring and dissolving; Add non-ionic surface active agent, skin protectant, citric acid successively, stirring and dissolving; Add ethanol, mix; Add the polyhexamethylene guanidine again, stir, promptly get described compound polyhexamethylene guanidine complexing iodine disinfector.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2009100536234A CN101926819A (en) | 2009-06-23 | 2009-06-23 | Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100536234A CN101926819A (en) | 2009-06-23 | 2009-06-23 | Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof |
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| CN101926819A true CN101926819A (en) | 2010-12-29 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012092776A1 (en) * | 2011-01-07 | 2012-07-12 | 上海宇昂化工科技发展有限公司 | High-stability non-ionic n-vinylbutyrolactam iodide solution and related formulation method therefor |
| CN102697803A (en) * | 2012-06-06 | 2012-10-03 | 上海利康生物高科技有限公司 | Cow nipple disinfectant with film forming and nursing effect, and preparation method of same |
| CN102846489A (en) * | 2012-09-03 | 2013-01-02 | 上海市奶牛研究所 | Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof |
| CN103503863A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Aquatic product dedicated hanging bag colloidal iodine disinfection drug |
| CN103735568A (en) * | 2013-12-19 | 2014-04-23 | 江西草珊瑚消毒用品有限公司 | Compound guanidine complex iodine skin mucosa disinfectant and preparation method thereof |
| CN103798230A (en) * | 2014-02-17 | 2014-05-21 | 韩羿斌 | Nano sterilization solution and preparation method thereof |
| CN104324047A (en) * | 2014-09-22 | 2015-02-04 | 天津大学 | New complex medical iodine disinfectant and preparation method thereof |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
| CN106821974A (en) * | 2017-03-29 | 2017-06-13 | 佛山市南海东方澳龙制药有限公司 | The preparation method of Betagen Solution and the Betagen Solution prepared by the method |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN114053299A (en) * | 2020-08-03 | 2022-02-18 | 成都中光洗消剂有限公司 | Compound iodine disinfectant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1712017A (en) * | 2004-06-21 | 2005-12-28 | 上海利康消毒高科技有限公司 | Two-purpose disinfectant for skin and muscous coat, its production |
| CN101310726A (en) * | 2007-05-22 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing polyhexamethylguanidine iodine disinfectant and preparation method thereof |
-
2009
- 2009-06-23 CN CN2009100536234A patent/CN101926819A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1712017A (en) * | 2004-06-21 | 2005-12-28 | 上海利康消毒高科技有限公司 | Two-purpose disinfectant for skin and muscous coat, its production |
| CN101310726A (en) * | 2007-05-22 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing polyhexamethylguanidine iodine disinfectant and preparation method thereof |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180368402A1 (en) * | 2011-01-07 | 2018-12-27 | Shanghai Yuking Water Soluble Material Tech Co., Ltd. | High stability non-ionic n-vinyl butyrolactam iodine and preparation method therefor |
| WO2012092776A1 (en) * | 2011-01-07 | 2012-07-12 | 上海宇昂化工科技发展有限公司 | High-stability non-ionic n-vinylbutyrolactam iodide solution and related formulation method therefor |
| CN102697803A (en) * | 2012-06-06 | 2012-10-03 | 上海利康生物高科技有限公司 | Cow nipple disinfectant with film forming and nursing effect, and preparation method of same |
| CN103503863A (en) * | 2012-06-25 | 2014-01-15 | 江苏天一健消毒剂有限公司 | Aquatic product dedicated hanging bag colloidal iodine disinfection drug |
| CN102846489A (en) * | 2012-09-03 | 2013-01-02 | 上海市奶牛研究所 | Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof |
| CN103735568A (en) * | 2013-12-19 | 2014-04-23 | 江西草珊瑚消毒用品有限公司 | Compound guanidine complex iodine skin mucosa disinfectant and preparation method thereof |
| CN103798230A (en) * | 2014-02-17 | 2014-05-21 | 韩羿斌 | Nano sterilization solution and preparation method thereof |
| CN104324047A (en) * | 2014-09-22 | 2015-02-04 | 天津大学 | New complex medical iodine disinfectant and preparation method thereof |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
| CN106821974A (en) * | 2017-03-29 | 2017-06-13 | 佛山市南海东方澳龙制药有限公司 | The preparation method of Betagen Solution and the Betagen Solution prepared by the method |
| CN106821974B (en) * | 2017-03-29 | 2021-04-02 | 佛山市南海东方澳龙制药有限公司 | Preparation method of povidone-iodine solution and povidone-iodine solution prepared by same |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN114053299A (en) * | 2020-08-03 | 2022-02-18 | 成都中光洗消剂有限公司 | Compound iodine disinfectant and preparation method thereof |
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Application publication date: 20101229 |