CN102670648B - Liquid iodine disinfectant, preparation method and used container thereof - Google Patents
Liquid iodine disinfectant, preparation method and used container thereof Download PDFInfo
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- CN102670648B CN102670648B CN201210186371.4A CN201210186371A CN102670648B CN 102670648 B CN102670648 B CN 102670648B CN 201210186371 A CN201210186371 A CN 201210186371A CN 102670648 B CN102670648 B CN 102670648B
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Abstract
The invention discloses a liquid iodine disinfectant, a preparation method and a used container thereof. The liquid iodine disinfectant comprises iodide, an oxidant capable of oxidizing the iodide to generate iodine molecules, and a pH regulator used for regulating the mixture of the iodide and the oxidant to be acidic, the disinfectant consists of a preparation I containing the iodide and a preparation II containing the oxidant and the pH regulator, and the preparation I and the preparation II are both liquid. The liquid iodine disinfectant disclosed by the invention is good in stability, can be stored for a long time, has little skin irritation, can permeate fast and volatilize quickly, does not need deiodination, and is light in coloring, excellent in sterilization effect, and safe and convenient to use and carry. The liquid iodine disinfectant disclosed by the invention has broad spectrum bactericidal action and low irritation to the skin mucosa, so that the liquid iodine disinfectant can be applied to various skin diseases caused by bacteria, funguses and viruses.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of liquid iodophor disinfectant preparation for skin degerming.
Background technology
Iodine is that the preparations such as everybody conventional sterile products, particularly iodine tincture (iodine tincture) are everybody very familiar sterilizing products, is widely used in hospital and daily life.Iodine is one of elimination agent of wide spectrum, can kill the microorganisms such as various antibacterials, fungus, virus in 100% ground, and not produce drug resistance.Also do not find in the world at present the microorganism to iodine drug resistance.
But the Operand using at present exists great defect: as iodine tincture (iodine tincture) etc. has the anaphylaxis of strong dyeability and adjuvant and too low activity.Causing the active too low main cause of current Operand is that the content of free molecular iodine in whole Operand is too low, and As time goes on its content also reduces continuing, and the content of the weak iodide ion of other forms of bactericidal action is very high.So not only affect the bactericidal effect of iodine, also human body skin has been produced to strong impulse effect, and can produce strong xanthochromia at site of action, affected attractive in appearance.And because iodine has volatility, if iodine can decline much with the rear active constituent content of the long-time placement of form of molecule, affect final use bactericidal effect.In order to ensure the Disinfection Effect of iodine tincture (iodine tincture), the higher iodine concentration of general use, the stimulation to skin while causing using is like this larger.These defects have greatly limited the range of application of iodine.
Summary of the invention
First technical problem to be solved by this invention is: the deficiency existing for prior art, and provide a kind of bactericidal effect good, little to skin irritation, good stability, can store for a long time and do not reduce the liquid iodophor disinfectant preparation of bactericidal effect.
Second technical problem to be solved by this invention is: provide a kind of bactericidal effect good, and little to skin irritation, good stability, can store for a long time and not reduce the preparation method of the liquid iodophor disinfectant preparation of bactericidal effect.
The 3rd technical problem to be solved by this invention is: a kind of container that is applicable to hold liquid disinfectant preparation is provided, uses easy to carry.
For solving above-mentioned first technical problem, technical scheme of the present invention is:
Liquid iodophor disinfectant preparation, comprise iodide, can make described iodide oxidation produce the oxidant of iodine molecule, with the mixture of described iodide and oxidant is adjusted to acid acidic ph modifier, described disinfectant preparation is combined by the preparation 1 that comprises described iodide and the preparation 2 that comprises described oxidant and acidic ph modifier, and described preparation 1 and preparation 2 are liquid form.
As the preferred technical scheme of one, described preparation is solution, and described solution is made up of the solution 1 that comprises described iodide and the solution 2 that comprises described oxidant and acidic ph modifier, the component that comprises following percetage by weight in described solution 1:
Iodide 0.1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
In solution 2, comprise the component of following percetage by weight:
Oxidant 0.1-5,
Acidic ph modifier 1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
Wherein, the wetting agent in solution 1 and solution 2, antiseptic, penetrating agent can select to add wherein one or more as required.
As the preferred technical scheme of another kind, described preparation is gel, described gel is made up of the gel 1 that comprises described iodide and the gel 2 that comprises described oxidant and acidic ph modifier, the component that comprises following percetage by weight in described gel 1:
Iodide 0.1-20,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
The component that comprises following percetage by weight in described gel 2:
Oxidant 0.1-5,
Acidic ph modifier 0.05-0.5,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
Wetting agent in gel 1 and gel 2, antiseptic, penetrating agent can select to add wherein one or more as required.
Wherein, described iodide are the iodine compound that can produce iodine anion in solution, and described iodine compound is one or more in sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and zinc iodide.
Described oxidant is the material that described iodide oxidation can be produced to iodine molecule, and described oxide is at least one in iodate, periodate.Preferred: one or more in sodium iodate, potassium iodate, Magnesium iodate., Copper diiodate(Cu(IO3)2), calcium iodate, zinc iodate, Potassium metaperiodate., sodium metaperiodate.This compounds has oxidisability, particularly, in sour environment, iodide oxidation can be produced to elemental iodine.
Described acidic ph modifier is one or more in phosphoric acid, citric acid, tartaric acid, salicylic acid, malic acid.Described acidic ph modifier by solution 1 with solution 2, gel 1 with below the mixed pH regulator to 6.0 of gel 2, be preferably adjusted to below 4.5.
Described wetting agent is one or both in the skin moisturizers such as glycerol, propylene glycol; Described antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate and propyl hydroxybenzoate; Described penetrating agent is one or both in menthol, azone.
Described polymer-based material is one or more in cellulose derivative class, guar gum, the xanthan gum such as methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hypromellose, hyetellose, hyprolose.
For solving above-mentioned second technical problem, technical scheme of the present invention is:
The method of preparing liquid iodophor disinfectant preparation, comprises the following steps:
A, according to the percentage by weight of each component in solution, iodide are dissolved in water at normal temperatures, as required, add one or more in alkaline pH regulator, dehydrated alcohol, wetting agent, penetrating agent and antiseptic, after mixed dissolution is complete, obtain solution 1; Oxidant is dissolved in water at normal temperatures, adds acidic ph modifier, then add one or more in dehydrated alcohol, wetting agent, penetrating agent and antiseptic, after mixed dissolution is complete, obtain solution 2;
B, according to the percentage by weight of each component in gel, by a small amount of water dissolution of iodide, polymer-based material is swelling with a small amount of water or dehydrated alcohol, then add the iodide of dissolving, add again one or more in alkaline pH regulator, wetting agent, penetrating agent and antiseptic, the water that adds surplus, stirs, and obtains gel 1; By a small amount of water dissolution of oxidant, polymer-based material is added water or dehydrated alcohol swelling, add oxidant, the acidic ph modifier of dissolving, then add one or more and the water of surplus in wetting agent, antiseptic, penetrating agent, stir, obtain gel 2.
For solving above-mentioned the 3rd technical problem, technical scheme of the present invention is:
The packing container that liquid iodophor disinfectant preparation is used, described container is provided with two separate chambers, is used for holding described preparation 1 and preparation 2;
Described two separate chambers have a common press device, and described press device is respectively equipped with the suction pipe that the chamber separate with two is communicated with, and while making to press described press device, can preparation 1 and preparation 2 be squeezed out simultaneously;
Or described two separate chambers are respectively equipped with independently press device, described two independently press device be respectively equipped with the suction pipe that the chamber separate with two is communicated with.
Owing to having adopted technique scheme, the invention has the beneficial effects as follows:
Iodine disinfectant preparation of the present invention comprises iodide, can make iodide oxidation produce the oxidant of iodine molecule, with the mixture of iodide and oxidant is adjusted to acid acidic ph modifier, and disinfectant preparation is combined by the preparation 1 that comprises iodide and the preparation 2 that comprises oxidant and acidic ph modifier, preparation 1 and preparation 2 are liquid form, therefore liquid formulation before use, iodine wherein can be present in preparation with its stable form, therefore there is good stability, can store for a long time.And the prolongation that when preparation uses, effective ingredient molecular iodine content can be not in time and declining, therefore the content of iodine in preparation does not need too high.When the present invention uses, after preparation 1 and preparation 2 mixes, in sour environment, can moment reaction produce required free molecule iodine, the free molecule iodine of generation can reach quick sterilization, antibacterial effect, because the molecular iodine producing in solution is the molecular iodine producing moment, therefore dissipation is effective, does not need higher concentration just can reach bactericidal effect, little to the zest of skin, infiltration rapidly, volatilization is fast, painted shallow, without de-iodine.
Dosage form of the present invention comprises solution and gel, and gel can form thin film at skin surface while use, is attached on skin, can extend the disinfection time, has long-acting bactericidal effect.And the molecular iodine being absorbed by human body skin has played bactericidal action, and the molecular iodine not being absorbed by the skin is stayed in gel film, can split away off, so just can not produce xanthochromia to skin, skin irritation is alleviated greatly, therefore can realize at sense organ sensitive part as the application of the skin at the positions such as face position, hand position.The present invention has broad-spectrum bactericidal action, low to Mucocutaneous zest, can be for the various dermatosiss that caused by antibacterial, fungus, virus.
The present invention uses special container to hold, container is provided with two separate chambers, be used for holding preparation 1 and preparation 2, there is a common press device, or two separate chambers are respectively equipped with independently press device, can squeeze out after two kinds of preparations directly mix simultaneously and use, use after the preparation 1 that also can concentration as required squeezes out different volumes mixes with preparation 2, portably uses convenience.
Detailed description of the invention
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment are only not used in and limit the scope of the invention for the present invention is described.In addition should be understood that those skilled in the art can make various changes or modifications the present invention after having read the content of the present invention's instruction, these equivalent form of values fall within the application's appended claims limited range equally.
Embodiment 1
Sodium iodide 1g is dissolved in water at normal temperatures, adds dehydrated alcohol 20g, menthol 0.1g, methyl hydroxybenzoate 0.1g, supplying water is 78.8g, after mixed dissolution is complete, obtains solution 1.Potassium metaperiodate. 0.3g is dissolved in water at normal temperatures, adds acidic ph modifier phosphoric acid 3.5g, dehydrated alcohol 20g, menthol 0.1g, methyl hydroxybenzoate 0.1g, supplying water is 76g, after mixed dissolution is complete, obtains solution 2.
When use, be 1:1:10 mixed dissolution (1 and 1 gram of solution 2 of 1 gram of solution is dissolved in 10 grams of water) in solution 1, solution 2 with the ratio of water, can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 2
Sodium iodide 8g is dissolved in water at normal temperatures, adds dehydrated alcohol 25g, ethyl hydroxybenzoate 0.2g, supplying water is 66.8g, after mixed dissolution is complete, obtains solution 1.Sodium iodate 2g is dissolved in water at normal temperatures, adds tartaric acid 20g, dehydrated alcohol 25g, ethyl hydroxybenzoate 0.2g, supplying water is 52.8g, after mixed dissolution is complete, obtains solution 2.
When use, be 1:1:100 mixed dissolution (1 and 1 gram of solution 2 of 1 gram of solution is dissolved in 100 grams of water) in solution 1, solution 2 with the ratio of water, can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 3
Magnesium iodide 20g is dissolved in water at normal temperatures, adds into water to 80g, mixed dissolution obtains solution 1 after completely.Potassium iodate 5g is dissolved in water at normal temperatures, adds phosphatase 11 5g to supply water 80g, after mixed dissolution is complete, obtain solution 2.
When use, be 1:1:100 mixed dissolution (1 and 1 gram of solution 2 of 1 gram of solution is dissolved in 100 grams of water) in solution 1, solution 2 with the ratio of water, can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 4
Potassium iodide 10g is dissolved in 58.8g water at normal temperatures, adds dehydrated alcohol 25g, glycerol 5g, azone 1g and propyl hydroxybenzoate 0.2g, after mixed dissolution is complete, obtain solution 1.Potassium iodate 3g is dissolved in water at normal temperatures, adds salicylic acid 1g and malic acid 9g, dehydrated alcohol 25g, propylene glycol 2g, menthol 0.5g, propyl hydroxybenzoate 0.2g, supply water 59.3g, after mixed dissolution is complete, obtain solution 2.
When use, be 1:1:50 mixed dissolution (1 and 1 gram of solution 2 of 1 gram of solution is dissolved in 50 grams of water) in solution 1, solution 2 with the ratio of water, can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 5
First by a small amount of water dissolution of potassium iodide 0.1g, sodium carboxymethyl cellulose 2g is swelling with 10g dehydrated alcohol, then add the iodide of dissolving, then add glycerol 10g and ethyl hydroxybenzoate 0.05g, supply water 77.85g, stir, obtain gel 1.By a small amount of water dissolution of Potassium metaperiodate. 0.1g, methylcellulose 2g is added to 10g dehydrated alcohol swelling, add Potassium metaperiodate., salicylic acid 0.2g, the glycerol 10g of dissolving, supply water 77.7g, stir, obtain gel 2.
When use, the ratio that is 1:1 in gel 1 and gel 2 is mixed homogeneously (1 gram of gel 1 is mixed homogeneously with 1 gram of gel 2), can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 6
First, by sodium iodide and potassium iodide 20g water dissolution, by swelling with dehydrated alcohol 30g to methylcellulose and ethyl cellulose 4g, then add sodium iodide and the potassium iodide of dissolving, add again menthol 1g and ethyl hydroxybenzoate 0.2g, supply water 44.8g, stir, obtain gel 1; First, by potassium iodate 4g water dissolution, hypromellose 4g is added to dehydrated alcohol 20g swelling, add potassium iodate, malic acid 0.3g, menthol 1g and the methyl hydroxybenzoate 0.2g of dissolving, supply water 70.5g, stir, obtain gel 2.
When use, the ratio that is 1:1 in gel 1 and gel 2 is mixed homogeneously (1 gram of gel 1 is mixed homogeneously with 1 gram of gel 2), can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 7
First the water dissolution with 61g by potassium iodide 5g, swelling with 30g dehydrated alcohol by sodium carboxymethyl cellulose 4g, then adds the potassium iodide of dissolving to stir, and obtains gel 1; First the water dissolution with 63.9g by potassium iodate 2g, swelling with 30g dehydrated alcohol by ethyl cellulose 4g, adds the potassium iodate of tartaric acid 0.1g and dissolving to stir, and obtains gel 2.
When use, the ratio that is 1:1 in gel 1 and gel 2 is mixed homogeneously (1 gram of gel 1 is mixed homogeneously with 1 gram of gel 2), can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Embodiment 8
First, by a small amount of water dissolution of potassium iodide 1g, xanthan gum 1g, with a small amount of water-soluble swollen, is then added to the potassium iodide of dissolving, then adds dehydrated alcohol 10g, azone 1g and propyl hydroxybenzoate 0.03g, supply the water of 86.97g, stir, obtain gel 1; First, by a small amount of water dissolution of sodium iodate 0.5g, xanthan gum 1g is added water swelling, add citric acid 0.5g, dehydrated alcohol 10g, supply water 88g, stir, obtain gel 2.
When use, the ratio that is 1:1 in gel 1 and gel 2 is mixed homogeneously (1 gram of gel 1 is mixed homogeneously with 1 gram of gel 2), can be made into the disinfectant sterilization that carries out disinfection.
After tested, the iodine disinfectant of the present embodiment, 5min on average kills logarithm value > 5.00 to Candida albicans, 5min on average kills logarithm value > 5.00 to staphylococcus aureus, and 5min is to the colibacillary logarithm value > 5.00 that on average kills.
Claims (4)
1. liquid iodophor disinfectant preparation, comprise iodide, can make described iodide oxidation produce the oxidant of iodine molecule, with the mixture of described iodide and oxidant is adjusted to acid acidic ph modifier, it is characterized in that: described disinfectant preparation is combined by the preparation 1 that comprises described iodide and the preparation 2 that comprises described oxidant and acidic ph modifier, and described preparation 1 and preparation 2 are liquid form;
Described preparation is gel, and described gel is made up of the gel 1 that comprises described iodide and the gel 2 that comprises described oxidant and acidic ph modifier, in described gel 1, is prepared from by the component of following percetage by weight:
In described gel 2, be prepared from by the component of following percetage by weight:
Described oxidant is the material that described iodide oxidation can be produced to iodine molecule, and described oxide is at least one in iodate, periodate;
Described polymer-based material is one or more in methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hypromellose, hyetellose, hyprolose, guar gum, xanthan gum;
Described acidic ph modifier is salicylic acid.
2. liquid iodophor disinfectant preparation as claimed in claim 1, it is characterized in that: described iodide are the iodine compound that can produce iodine anion in solution, and described iodine compound is one or more in sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and zinc iodide.
3. liquid iodophor disinfectant preparation as claimed in claim 1, is characterized in that: described wetting agent is one or both in glycerol, propylene glycol; Described antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate and propyl hydroxybenzoate; Described penetrating agent is one or both in menthol, azone.
4. the method for preparation liquid iodophor disinfectant preparation as claimed in claim 1, is characterized in that comprising the following steps:
According to the percentage by weight of each component in gel, by a small amount of water dissolution of iodide, polymer-based material is swelling with a small amount of water or dehydrated alcohol, then add the iodide of dissolving, then add wetting agent, penetrating agent and antiseptic, add the water of surplus, stir, obtain gel 1; By a small amount of water dissolution of oxidant, polymer-based material is added water or dehydrated alcohol swelling, add the water of oxidant, acidic ph modifier, wetting agent, antiseptic, penetrating agent and the surplus of dissolving, stir, obtain gel 2.
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| CN201210186371.4A CN102670648B (en) | 2012-06-07 | 2012-06-07 | Liquid iodine disinfectant, preparation method and used container thereof |
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| CN201210186371.4A CN102670648B (en) | 2012-06-07 | 2012-06-07 | Liquid iodine disinfectant, preparation method and used container thereof |
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| CN102670648B true CN102670648B (en) | 2014-07-30 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015153258A1 (en) * | 2014-03-31 | 2015-10-08 | Iotech International, Llc | Stable compositions of uncomplexed iodine and methods of use |
| CN110201190B (en) * | 2019-06-27 | 2021-12-14 | 施瑞华 | Coloring agent for early diagnosis of esophageal cancer and preparation method thereof |
| CN111437288A (en) * | 2020-05-20 | 2020-07-24 | 山东沙多普生物科技有限公司 | Atomized molecular iodine disinfectant and application thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098252A (en) * | 1988-04-11 | 1995-02-08 | 埃培托普公司 | The solid germicidal pre-iodine composition of stable storing |
| CN101541333A (en) * | 2006-06-22 | 2009-09-23 | 生物杀灭剂药品公司 | Method for the eradication of pathogens comprising generating molecular iodine in situ |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432426B2 (en) * | 1998-11-30 | 2002-08-13 | Symbollon Corporation | Non-staining topical iodine composition and method |
| CN202072042U (en) * | 2011-05-16 | 2011-12-14 | 范小黄 | Bottle with double containing cavities |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098252A (en) * | 1988-04-11 | 1995-02-08 | 埃培托普公司 | The solid germicidal pre-iodine composition of stable storing |
| CN101541333A (en) * | 2006-06-22 | 2009-09-23 | 生物杀灭剂药品公司 | Method for the eradication of pathogens comprising generating molecular iodine in situ |
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Effective date of registration: 20211020 Address after: 261205 R & D Center (room 332, block g, biomedicine, Gaoxin 2nd Road), south of Jiankang street, Gaoxin District, Weifang City, Shandong Province Patentee after: Shandong sardopu Biotechnology Co.,Ltd. Address before: 261205 Room 301, national incubator, biological park, intersection of Gaoxin Second Road and Jiankang street, high tech Zone, Weifang City, Shandong Province Patentee before: WINERGEN SCIENCE AND TECHNOLOGY (WEIFANG) Co.,Ltd. |