CN102670648A - Liquid iodine disinfectant, preparation method and used container thereof - Google Patents
Liquid iodine disinfectant, preparation method and used container thereof Download PDFInfo
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- CN102670648A CN102670648A CN2012101863714A CN201210186371A CN102670648A CN 102670648 A CN102670648 A CN 102670648A CN 2012101863714 A CN2012101863714 A CN 2012101863714A CN 201210186371 A CN201210186371 A CN 201210186371A CN 102670648 A CN102670648 A CN 102670648A
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Abstract
The invention discloses a liquid iodine disinfectant, a preparation method and a used container thereof. The liquid iodine disinfectant comprises iodide, an oxidant capable of oxidizing the iodide to generate iodine molecules, and a pH regulator used for regulating the mixture of the iodide and the oxidant to be acidic, the disinfectant consists of a preparation I containing the iodide and a preparation II containing the oxidant and the pH regulator, and the preparation I and the preparation II are both liquid. The liquid iodine disinfectant disclosed by the invention is good in stability, can be stored for a long time, has little skin irritation, can permeate fast and volatilize quickly, does not need deiodination, and is light in coloring, excellent in sterilization effect, and safe and convenient to use and carry. The liquid iodine disinfectant disclosed by the invention has broad spectrum bactericidal action and low irritation to the skin mucosa, so that the liquid iodine disinfectant can be applied to various skin diseases caused by bacteria, funguses and viruses.
Description
Technical field
The present invention relates to medical technical field, relate in particular to a kind of liquid iodophor disinfectant preparation that is used for skin degerming.
Background technology
Iodine is that the sterile products that everybody uses always, particularly iodine tincture preparations such as (iodine tinctures) is everybody very familiar sterilizing product, is widely used in hospital and the daily life.Iodine is one of broad-spectrum elimination agent, can kill microorganisms such as various antibacterials, fungus, virus in 100% ground, and not produce drug resistance.Also do not find in the world at present the drug-fast microorganism of iodine.
But the Operand that uses at present exists great defective: like iodine tincture (iodine tincture) etc. the anaphylaxis of intensive dyeability and adjuvant and low excessively activity are arranged.Causing the low excessively main cause of present Operand activity is that the content of free molecular iodine in whole Operand is too low, and As time goes on its content is also continuing reduction, and the content of the iodide ion a little less than the other forms of bactericidal action is very high.So not only influenced the bactericidal effect of iodine, also human body skin has been produced the strong impulse effect, and can produce intensive xanthochromia property, influenced attractive in appearance at site of action.And because iodine has volatility, can descend much if iodine is placed the back active constituent content for a long time with the form of molecule, influence final use bactericidal effect.In order to guarantee the Disinfection Effect of iodine tincture (iodine tincture), generally use higher iodine concentration, the stimulation to skin when causing using like this is bigger.These defectives have greatly limited the range of application of iodine.
Summary of the invention
First technical problem to be solved by this invention is: the deficiency to prior art exists, and provide a kind of bactericidal effect good, little to skin irritation, good stability, can store for a long time and do not reduce the liquid iodophor disinfectant preparation of bactericidal effect.
Second technical problem to be solved by this invention is: provide a kind of bactericidal effect good, and little to skin irritation, good stability, can store for a long time and do not reduce the method for preparing of the liquid iodophor disinfectant preparation of bactericidal effect.
The 3rd technical problem to be solved by this invention is: a kind of container that holds liquid disinfectant preparation that is applicable to is provided, uses easy to carry.
For solving above-mentioned first technical problem, technical scheme of the present invention is:
The liquid iodophor disinfectant preparation; Comprise iodide; Can make said iodide oxidation produce the oxidant of iodine molecule; Be adjusted to tart acidic ph modifier with the mixture with said iodide and oxidant, said disinfectant preparation is combined by preparation that comprises said iodide 1 and the preparation 2 that comprises said oxidant and acidic ph modifier, and said preparation 1 is liquid form with preparation 2.
As a kind of optimized technical scheme, said preparation is a solution, and said solution is made up of solution that comprises said iodide 1 and the solution 2 that comprises said oxidant and acidic ph modifier, comprises the component of following percetage by weight in the said solution 1:
Iodide 0.1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
The component that comprises following percetage by weight in the solution 2:
Oxidant 0.1-5,
Acidic ph modifier 1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
Wherein, the wetting agent in solution 1 and the solution 2, antiseptic, penetrating agent can select to add wherein one or more as required.
As another kind of optimized technical scheme; Said preparation is a gel; Said gel is made up of gel that comprises said iodide 1 and the gel 2 that comprises said oxidant and acidic ph modifier, comprises the component of following percetage by weight in the said gel 1:
Iodide 0.1-20,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
The component that comprises following percetage by weight in the said gel 2:
Oxidant 0.1-5,
Acidic ph modifier 0.05-0.5,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
Wetting agent in gel 1 and the gel 2, antiseptic, penetrating agent can select to add wherein one or more as required.
Wherein, said iodide are for can produce the anionic iodine compound of iodine in solution, and said iodine compound is one or more in sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and the zinc iodide.
Said oxidant is the material that can said iodide oxidation be produced iodine molecule, and said oxide is at least a in iodate, the periodate.Preferably: one or more in sodium iodate, potassium iodate, Magnesium iodate., Copper diiodate(Cu(IO3)2), calcium iodate, zinc iodate, Potassium metaperiodate., the sodium metaperiodate.This compounds has oxidisability, particularly in sour environment, can the iodide oxidation be produced elemental iodine.
Said acidic ph modifier is one or more in phosphoric acid, citric acid, tartaric acid, salicylic acid, the malic acid.Said acidic ph modifier with below the gel 2 mixed pH regulator to 6.0, preferably is adjusted to solution 1 and solution 2, gel 1 below 4.5.
Said wetting agent is one or both in the skin moisturizers such as glycerin, propylene glycol; Said antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propyl hydroxybenzoate; Said penetrating agent is one or both in menthol, the azone.
Said polymer-based material is one or more in cellulose derivative class, guar gum, the xanthan gum such as methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hypromellose, hyetellose, hyprolose.
For solving above-mentioned second technical problem, technical scheme of the present invention is:
Prepare the method for liquid iodophor disinfectant preparation, may further comprise the steps:
A, according to the percentage by weight of each component in the solution; Be dissolved in iodide in the water at normal temperatures; As required, one or more in adding alkaline pH regulator, dehydrated alcohol, wetting agent, penetrating agent and the antiseptic promptly get solution 1 after mixed dissolution is complete; Oxidant is dissolved in the water at normal temperatures, adds acidic ph modifier, add in dehydrated alcohol, wetting agent, penetrating agent and the antiseptic one or more then, promptly get solution 2 after mixed dissolution is complete;
B, according to the percentage by weight of each component in the gel; Iodide are dissolved with low amounts of water, polymer-based material with low amounts of water or dehydrated alcohol swelling, is added dissolved iodide then; Add in alkaline pH regulator, wetting agent, penetrating agent and the antiseptic one or more again; Add the water of surplus, stir, promptly get gel 1; Oxidant is dissolved with low amounts of water; Polymer-based material is added water or dehydrated alcohol swelling, add dissolved oxidant, acidic ph modifier, add the water of one or more and surplus in wetting agent, antiseptic, the penetrating agent again; Stir, promptly get gel 2.
For solving above-mentioned the 3rd technical problem, technical scheme of the present invention is:
The used packing container of a kind of liquid iodophor disinfectant preparation, said container is provided with two separate chambers, is used for holding said preparation 1 and preparation 2;
Said two separate chambers have a common press device, and said press device is respectively equipped with the suction pipe that is communicated with two separate chambers, make simultaneously preparation 1 and preparation 2 extruding to be come out when pushing said press device;
Perhaps, said two separate chambers are respectively equipped with independently press device, said two independently press device be respectively equipped with the suction pipe that is communicated with two separate chambers.
Owing to adopted technique scheme, the invention has the beneficial effects as follows:
Iodine disinfectant preparation of the present invention comprises iodide; Can make the iodide oxidation produce the oxidant of iodine molecule; Be adjusted to tart acidic ph modifier with the mixture with iodide and oxidant, and disinfectant preparation combines by preparation that comprises iodide 1 and the preparation 2 that comprises oxidant and acidic ph modifier, preparation 1 and preparation 2 are liquid form; Therefore liquid formulation before use; Iodine wherein can be present in the preparation with its stable form, therefore good stability is arranged, and can store for a long time.And the prolongation that effective ingredient molecular iodine content can be not in time when preparation used and descending, so the content of iodine in the preparation does not need too high.When the present invention uses, after preparation 1 mixes with preparation 2, in sour environment, can the moment reaction produce required free molecule iodine; The free molecule iodine that produces can reach quick sterilization, bacteriostatic effect, because the molecular iodine that produces in the solution is the molecular iodine that produces moment, it is effective extremely therefore to disappear; Do not need higher concentration just can reach bactericidal effect, little to the zest of skin, infiltration rapidly; Volatilization is fast, and is painted shallow, need not to take off iodine.
Dosage form of the present invention comprises solution and gel, and gel can form thin film at skin surface when using, and is attached on the skin, can prolong the disinfection time, has the long-acting bactericidal effect.And the molecular iodine that is absorbed by human body skin has played bactericidal action; And do not stayed in the gel film by the molecular iodine of skin absorbs; Can split away off; So just can not produce xanthochromia property, skin irritation is alleviated greatly, therefore can be implemented in the application of the skin at sense organ sensitive part such as positions such as face position, hand position skin.The present invention has broad-spectrum bactericidal action, and is low to Mucocutaneous zest, can be used for the various dermatosiss that caused by antibacterial, fungus, virus.
The present invention uses special container to hold; Container is provided with two separate chambers, is used for holding preparation 1 and preparation 2, has a common press device; Perhaps two separate chambers are respectively equipped with independently press device; Can squeeze out two kinds of preparations simultaneously and directly mix the back and use, the preparation 1 that also can concentration as required squeezes out different volumes mixes the back use with preparation 2, portably use convenience.
The specific embodiment
Below in conjunction with concrete embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in the restriction scope of the present invention.Should be understood that in addition those skilled in the art can do various changes or modification to the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
Sodium iodide 1g is dissolved in the water at normal temperatures, adds dehydrated alcohol 20g, menthol 0.1g, methyl hydroxybenzoate 0.1g, supplying water is 78.8g, promptly gets solution 1 after mixed dissolution is complete.Potassium metaperiodate. 0.3g is dissolved in the water at normal temperatures, adds acidic ph modifier phosphoric acid 3.5g, dehydrated alcohol 20g, menthol 0.1g, methyl hydroxybenzoate 0.1g, supplying water is 76g, promptly gets solution 2 after mixed dissolution is complete.
During use, be 1:1:10 mixed dissolution (i.e. 1 gram solution 1 and 1 restrain solution 2 be dissolved in 10 and restrain in the water), can be made into the disinfectant antibacterial that carries out disinfection in the ratio of solution 1, solution 2 and water.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 2
Sodium iodide 8g is dissolved in the water at normal temperatures, adds dehydrated alcohol 25g, ethyl hydroxybenzoate 0.2g, supplying water is 66.8g, promptly gets solution 1 after mixed dissolution is complete.Sodium iodate 2g is dissolved in the water at normal temperatures, adds tartaric acid 20g, dehydrated alcohol 25g, ethyl hydroxybenzoate 0.2g, supplying water is 52.8g, promptly gets solution 2 after mixed dissolution is complete.
During use, be 1:1:100 mixed dissolution (i.e. 1 gram solution 1 and 1 restrain solution 2 be dissolved in 100 and restrain in the water), can be made into the disinfectant antibacterial that carries out disinfection in the ratio of solution 1, solution 2 and water.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 3
Magnesium iodide 20g is dissolved in the water at normal temperatures, adds entry, promptly get solution 1 after mixed dissolution is complete to 80g.Potassium iodate 5g is dissolved in the water at normal temperatures, adds phosphatase 11 5g and supply water 80g, promptly get solution 2 after mixed dissolution is complete.
During use, be 1:1:100 mixed dissolution (i.e. 1 gram solution 1 and 1 restrain solution 2 be dissolved in 100 and restrain in the water), can be made into the disinfectant antibacterial that carries out disinfection in the ratio of solution 1, solution 2 and water.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 4
Potassium iodide 10g is dissolved in the 58.8g water at normal temperatures, adds dehydrated alcohol 25g, glycerin 5g, azone 1g and propyl hydroxybenzoate 0.2g, promptly get solution 1 after mixed dissolution is complete.Potassium iodate 3g is dissolved in the water at normal temperatures, adds salicylic acid 1g and malic acid 9g, dehydrated alcohol 25g, propylene glycol 2g, menthol 0.5g, propyl hydroxybenzoate 0.2g, supply water 59.3g, promptly get solution 2 after mixed dissolution is complete.
During use, be 1:1:50 mixed dissolution (i.e. 1 gram solution 1 and 1 restrain solution 2 be dissolved in 50 and restrain in the water), can be made into the disinfectant antibacterial that carries out disinfection in the ratio of solution 1, solution 2 and water.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 5
Earlier potassium iodide 0.1g is dissolved with low amounts of water, sodium carboxymethyl cellulose 2g with 10g dehydrated alcohol swelling, is added dissolved iodide then, add glycerin 10g and ethyl hydroxybenzoate 0.05g again, supply water 77.85g, stir, promptly get gel 1.0.1g dissolves with low amounts of water with Potassium metaperiodate., and methylcellulose 2g is added 10g dehydrated alcohol swelling, adds dissolved Potassium metaperiodate., salicylic acid 0.2g, glycerin 10g, supplies water 77.7g, stirs, and promptly gets gel 2.
During use, press gel 1 and gel 2 and be the mixed of 1:1 evenly (promptly 1 gram gel 1 and 1 restrains gel 2 mix homogeneously), can be made into the disinfectant antibacterial that carries out disinfection.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 6
Earlier sodium iodide and potassium iodide 20g are used water dissolution, methylcellulose and ethyl cellulose 4g with dehydrated alcohol 30g swelling, are added dissolved sodium iodide and potassium iodide then; Add menthol 1g and ethyl hydroxybenzoate 0.2g again; Supply water 44.8g, stir, promptly get gel 1; Earlier potassium iodate 4g is used water dissolution, hypromellose 4g is added dehydrated alcohol 20g swelling, add dissolved potassium iodate, malic acid 0.3g, menthol 1g and methyl hydroxybenzoate 0.2g, supply water 70.5g, stir, promptly get gel 2.
During use, press gel 1 and gel 2 and be the mixed of 1:1 evenly (promptly 1 gram gel 1 and 1 restrains gel 2 mix homogeneously), can be made into the disinfectant antibacterial that carries out disinfection.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 7
With the water dissolution of potassium iodide 5g, sodium carboxymethyl cellulose 4g with 30g dehydrated alcohol swelling, is added dissolved potassium iodide then and stirs earlier, promptly get gel 1 with 61g; With the water dissolution of potassium iodate 2g, ethyl cellulose 4g with 30g dehydrated alcohol swelling, is added tartaric acid 0.1g and dissolved potassium iodate and stirs earlier, promptly get gel 2 with 63.9g.
During use, press gel 1 and gel 2 and be the mixed of 1:1 evenly (promptly 1 gram gel 1 and 1 restrains gel 2 mix homogeneously), can be made into the disinfectant antibacterial that carries out disinfection.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Embodiment 8
Earlier potassium iodide 1g is dissolved with low amounts of water, xanthan gum 1g is used the low amounts of water swelling, add dissolved potassium iodide then, add dehydrated alcohol 10g, azone 1g and propyl hydroxybenzoate 0.03g again, supply the water of 86.97g, stir, promptly get gel 1; Earlier sodium iodate 0.5g is dissolved with low amounts of water, xanthan gum 1g is added water-soluble expanding, add citric acid 0.5g, dehydrated alcohol 10g, supply water 88g, stir, promptly get gel 2.
During use, press gel 1 and gel 2 and be the mixed of 1:1 evenly (promptly 1 gram gel 1 and 1 restrains gel 2 mix homogeneously), can be made into the disinfectant antibacterial that carries out disinfection.
Through test, the iodine disinfectant of present embodiment, 5min be to oidiomycetic logarithm value＞5.00 of on average killing of white, and 5min on average kills logarithm value＞5.00 to staphylococcus aureus, and 5min is to colibacillary logarithm value＞5.00 of on average killing.
Claims (10)
1. liquid iodophor disinfectant preparation; Comprise iodide; Can make said iodide oxidation produce the oxidant of iodine molecule; Be adjusted to tart acidic ph modifier with the mixture with said iodide and oxidant, it is characterized in that: said disinfectant preparation is combined by preparation that comprises said iodide 1 and the preparation 2 that comprises said oxidant and acidic ph modifier, and said preparation 1 is liquid form with preparation 2.
2. liquid iodophor disinfectant preparation as claimed in claim 1; It is characterized in that: said preparation is a solution; Said solution is made up of solution that comprises said iodide 1 and the solution 2 that comprises said oxidant and acidic ph modifier, comprises the component of following percetage by weight in the said solution 1:
Iodide 0.1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
The component that comprises following percetage by weight in the solution 2:
Oxidant 0.1-5,
Acidic ph modifier 1-20,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
3. liquid iodophor disinfectant preparation as claimed in claim 1; It is characterized in that: said preparation is a gel; Said gel is made up of gel that comprises said iodide 1 and the gel 2 that comprises said oxidant and acidic ph modifier, comprises the component of following percetage by weight in the said gel 1:
Iodide 0.1-20,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus;
The component that comprises following percetage by weight in the said gel 2:
Oxidant 0.1-5,
Acidic ph modifier 0.05-0.5,
Polymer-based material 0.5-6,
Dehydrated alcohol 0-30,
Wetting agent 0-15,
Antiseptic 0-0.5,
Penetrating agent 0-2,
Water surplus.
4. like claim 2 or 3 described liquid iodophor disinfectant preparations; It is characterized in that: said iodide are for can produce the anionic iodine compound of iodine in solution, said iodine compound is one or more in sodium iodide, potassium iodide, magnesium iodide, calcium iodide, manganese iodide, ammonium iodide and the zinc iodide.
5. like claim 2 or 3 described liquid iodophor disinfectant preparations, it is characterized in that: said oxidant be for producing said iodide oxidation the material of iodine molecule, and said oxide is at least a in iodate, the periodate.
6. like claim 2 or 3 described liquid iodophor disinfectant preparations, it is characterized in that: said acidic ph modifier is one or more in phosphoric acid, citric acid, tartaric acid, salicylic acid, the malic acid.
7. like claim 2 or 3 described liquid iodophor disinfectant preparations, it is characterized in that: said wetting agent is one or both in glycerin, the propylene glycol; Said antiseptic is one or more in methyl hydroxybenzoate, ethyl hydroxybenzoate and the propyl hydroxybenzoate; Said penetrating agent is one or both in menthol, the azone.
8. like claim 2 or 3 described liquid iodophor disinfectant preparations, it is characterized in that: said polymer-based material is one or more in methylcellulose, ethyl cellulose, sodium carboxymethyl cellulose, hypromellose, hyetellose, hyprolose, guar gum, the xanthan gum.
9. preparation is characterized in that may further comprise the steps like the method for claim 2 or 3 described liquid iodophor disinfectant preparations:
A, according to the percentage by weight of each component in the solution, iodide are dissolved in the water at normal temperatures, add alkaline pH regulator, dehydrated alcohol, wetting agent, penetrating agent and antiseptic, mixed dissolution promptly gets solution 1 after fully; Oxidant is dissolved in the water at normal temperatures, adds acidic ph modifier, add dehydrated alcohol, wetting agent, penetrating agent and antiseptic then, promptly get solution 2 after mixed dissolution is complete;
B, according to the percentage by weight of each component in the gel; Iodide are dissolved with low amounts of water, polymer-based material with low amounts of water or dehydrated alcohol swelling, is added dissolved iodide then; Add alkaline pH regulator, wetting agent, penetrating agent and antiseptic again; Add the water of surplus, stir, promptly get gel 1; Oxidant is dissolved with low amounts of water, polymer-based material is added water or dehydrated alcohol swelling, add the water of dissolved oxidant, acidic ph modifier, wetting agent, antiseptic, penetrating agent and surplus, stir, promptly get gel 2.
10. packing container that the liquid iodophor disinfectant preparation is used, it is characterized in that: said container is provided with two separate chambers, is used for holding said preparation 1 and preparation 2;
Said two separate chambers have a common press device, and said press device is respectively equipped with the suction pipe that is communicated with two separate chambers, make simultaneously preparation 1 and preparation 2 extruding to be come out when pushing said press device;
Perhaps, said two separate chambers are respectively equipped with independently press device, said two independently press device be respectively equipped with the suction pipe that is communicated with two separate chambers.
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| CN110201190A (en) * | 2019-06-27 | 2019-09-06 | 施瑞华 | A kind of coloring agent and preparation method thereof for cancer of the esophagus early diagnosis |
| CN111437288A (en) * | 2020-05-20 | 2020-07-24 | 山东沙多普生物科技有限公司 | Atomized molecular iodine disinfectant and application thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
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| KR20160140691A (en) * | 2014-03-31 | 2016-12-07 | 아이오테크 인터내셔널, 인코퍼레이티드 | Stable compositions of uncomplexed iodine and methods of use |
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| CN110201190A (en) * | 2019-06-27 | 2019-09-06 | 施瑞华 | A kind of coloring agent and preparation method thereof for cancer of the esophagus early diagnosis |
| CN110201190B (en) * | 2019-06-27 | 2021-12-14 | 施瑞华 | Coloring agent for early diagnosis of esophageal cancer and preparation method thereof |
| CN111437288A (en) * | 2020-05-20 | 2020-07-24 | 山东沙多普生物科技有限公司 | Atomized molecular iodine disinfectant and application thereof |
| CN113615708A (en) * | 2021-07-19 | 2021-11-09 | 西安交通大学 | Corneal contact lens nursing composition, preparation method and application |
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