CN105012347B - Skin-rehabilitating agent and preparation method thereof containing fullerene water soluble derivatives - Google Patents
Skin-rehabilitating agent and preparation method thereof containing fullerene water soluble derivatives Download PDFInfo
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- CN105012347B CN105012347B CN201510449840.0A CN201510449840A CN105012347B CN 105012347 B CN105012347 B CN 105012347B CN 201510449840 A CN201510449840 A CN 201510449840A CN 105012347 B CN105012347 B CN 105012347B
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Abstract
Skin-rehabilitating agent and preparation method thereof containing fullerene water soluble derivatives, is related to the field of skin-rehabilitating agent and preparation method thereof.The present invention solves the problem of traditional skin repair agent does not have apparent inhibiting effect for malaise symptoms such as pruituses brought by cell damage, ideal therapeutic state is not achieved.Skin-rehabilitating agent containing fullerene water soluble derivatives, specifically includes: fullerene water soluble derivatives, iodine, iodine stabilizer, iodine complexing agent, surfactant, organic acid, pH adjusting agent and pure water.Iodo-complexes ingredient can efficiently kill the pathogenic bacteria such as bacterium, gemma, protozoon, the fungi on skin infection surface in the present invention; gel component can protect wound isolation outside contamination; faintly acid needed for construction is conducive to wound healing, wet microenvironment; fullerene ingredient permeability with higher; it can be by body Transdermal absorption; free radical is largely adsorbed in wound layer, promotes the reparation and regeneration of damaged cell, hence it is evident that improves the malaise symptoms such as itch.
Description
Technical field
The present invention relates to the fields of skin-rehabilitating agent and preparation method thereof, more particularly to derivative containing fullerene water dissolubility
Skin-rehabilitating agent of object and preparation method thereof.
Background technique
Skin infection is to seriously affect one of evil disease of people's life health, and attention is such as not added, some even can jeopardize life
Life.Skin ecto-entad is successively epidermis, corium, subcutaneous tissue, and intradermal contains nerve and itches, pain, hot, cold, tactile etc.
Sensory nerve ending.Dermopathic primary subjective performance is all in epidermis, and cardinal symptom is blood vessel, the mind due to invading skin corium
Through, senses of discomfort such as itch, pain caused by sweat gland, sebaceous glands etc..Common skin infection is usually caused by bacterium or fungi
Wound or cutaneous lesions, such as infection of staphylococcus aureus, various skin tineas, eczema etc..Free radical is that one kind contains
The general name of the atom of unpaired electron, atomic group or molecule.Under pathological state, a large amount of free radicals that body generates can be damaged
DNA is the main inducing of Apoptosis, necrosis.After traditional skin repair agent is for cell damage, skin caused by free radical
The malaise symptoms such as skin itch do not have apparent inhibiting effect, and ideal therapeutic state is not achieved.
Fullerene is the third isotope isomer of carbon, famous with unique cage structure, prominent representative therein
C60, it is made of 60 carbon atoms, shares 60 pi-electrons, is distributed in one big pi bond of formation in carbon ball, it has typical lack
Electronics alkene feature can be used as electron acceptor, receive 1~6 electronics, form C-1 60~C-6 60Radical anion；It can be with
It is ideal free radical scavenger and antioxidant with radical reaction.
Fullerene surface has a large amount of double covalent bonds, it is easy to be invaded by free radical, someone is referred to as " free radical sea
It is continuous ", it is current most effective free radical scavenger.It has been reported that 34 methyl freedom at most can be absorbed in a fullerene molecule
Base.Just because of this characteristic, fullerene have anti-oxidant and cytoprotection, promote wound healing, while can alleviate by
The senses of discomfort such as the itch caused by cell damage.
Summary of the invention
The present invention provides the skin-rehabilitating agents and preparation method thereof containing fullerene water soluble derivatives.
Skin-rehabilitating agent containing fullerene water soluble derivatives, it is specifically included: the fullerene of 0.02-0.1% (W/V)
Soluble derivative, the iodine of 0.01-0.02% (W/V), the iodine stabilizer of 0.02-0.04% (W/V), 0.02-0.04% (W/V)
Iodine complexing agent, the surfactant of 0.6-0.8% (W/V), the organic acid of 0.01-0.03% (W/V), 0.01-0.03% (W/
V the pure water of pH adjusting agent and surplus).
The preparation method of skin-rehabilitating agent containing fullerene water soluble derivatives specifically carries out according to the following steps:
One, part pure water is taken, under conditions of continuously stirring, it is derivative that fullerene water dissolubility is sequentially added into pure water
Uniform component A is made in object, organic acid；
Two, part pure water separately is taken, under conditions of continuously stirring, iodine stabilizer, iodine is sequentially added into pure water, made
Obtain uniform B component；
Three, separately take part pure water again, under conditions of continuously stirring, sequentially added into pure water surfactant,
Uniform component C is made in iodine complexing agent；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, the dilution of remaining pure water is added to F component made from step 5, be then added pH adjusting agent adjust pH value to
5-6 is to get having arrived the skin-rehabilitating agent containing fullerene water soluble derivatives.
Skin-rehabilitating agent containing fullerene water soluble derivatives, it further includes the gel preparation of 0.1-1.5% (W/V).
The preparation method of skin-rehabilitating agent containing fullerene water soluble derivatives specifically carries out according to the following steps:
One, part pure water is taken, under conditions of continuously stirring, it is derivative that fullerene water dissolubility is sequentially added into pure water
Uniform component A is made in object, organic acid；
Two, part pure water separately is taken, under conditions of continuously stirring, iodine stabilizer, iodine is sequentially added into pure water, made
Obtain uniform B component；
Three, separately take part pure water again, under conditions of continuously stirring, sequentially added into pure water surfactant,
Uniform component C is made in iodine complexing agent；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, under conditions of continuously stirring, gel preparation is added to F component made from step 5, is uniformly mixed, is made even
The gel component of phase；Then remaining pure water dilution is added into gel component, adds pH adjusting agent and adjusts pH value
To 5-6 to get having arrived the skin-rehabilitating agent containing fullerene water soluble derivatives.
The fullerene water soluble derivatives are fullerene hydroxylation derivative, fullerene aminoacid derivate, fowler
One of alkene carboxylated derivative and fulleropyrrolidine derivative or in which several mixtures.
The organic acid is one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixing
Object.
The iodine stabilizer is KI, NaI, KIO3And NaIO3One of or in which several mixtures；The iodine
Complexing agent is in biguanides amino-compound and hyperbranched Gemini quaternary ammonium salt amino-compound with synergic remove
One or more of mixtures.
The surfactant is the nonionic surface active agent of fatty alcohol polyethenoxy ether class.
The pH adjusting agent is sodium bicarbonate.
The gel preparation is in sodium alginate, hyaluronic acid, gelatin, yellow glue original, allantoin amino acid and Aloe Vera Gel
One kind or in which several mixtures.
Advantages of the present invention: the one, preparation method of the skin-rehabilitating agent of the invention containing fullerene water soluble derivatives
Simply, what is be prepared does not add hormone constituents containing fullerene water soluble derivatives, and safety is mild, non-stimulated, compensates for
The blank of similar products currently on the market；Two, with richness in the skin-rehabilitating agent of the invention containing fullerene water soluble derivatives
Skin repair agent of the alkene soluble derivative as principle active component is strangled, and strong bactericidal agent iodo-complexes and contains moisturizing
The gel preparation of ingredient is used cooperatively, can not only efficiently kill damaged skin surface the bacterium for effectively removing skin trauma face,
The harmful microorganisms such as gemma, protozoon, fungi, weak acid needed for protecting wound isolation outside contamination, construction to be conducive to wound healing
Property, wet microenvironment, and permeability is high, can largely adsorb free radical in wound layer by wound Transdermal absorption, promotes impaired thin
The reparation and regeneration of born of the same parents, hence it is evident that improve the malaise symptoms such as the itch as caused by cell damage；Three, of the invention to contain fullerene
It is also aqua that the skin-rehabilitating agent of soluble derivative, which can be gel preparation, and when use directly can smear or spray as needed
Body disease sites are coated in, it is simple to operate, it is more humanized.
Specific embodiment
The technical solution of the present invention is not limited to the following list, further includes between each specific embodiment
Any combination.
Specific embodiment 1: present embodiments provide for the skin-rehabilitating agent containing fullerene water soluble derivatives, it
It specifically includes: the fullerene water soluble derivatives of 0.02-0.1% (W/V), the iodine of 0.01-0.02% (W/V), 0.02-0.04%
(W/V) iodine stabilizer, the iodine complexing agent of 0.02-0.04% (W/V), the surfactant of 0.6-0.8% (W/V), 0.01-
The organic acid of 0.03% (W/V), the pH adjusting agent of 0.01-0.03% (W/V) and the pure water of surplus.
Fullerene water soluble derivatives described in present embodiment have anti-oxidant and cytoprotection, promote wound
Mouth healing, while the sense of discomfort as caused by cell damage can be alleviated.
Iodine described in present embodiment is the elemental iodine of solid state, is a kind of efficient, wide spectrum bacteria remover, can kill thin
The pathogen such as bacterium, brood cell, virus, bacteriophage, mycobacteria, protozoon, fungi.
Surfactant described in present embodiment can be such that iodine is stable in the presence of in solution.
Iodine complexing agent described in present embodiment serves not only as the complexing agent of iodine, moreover it is possible to increase the stabilization of iodine in the solution
Property, while synergic remove is played with iodine, and enhance the bactericidal activity of iodine.
Organic acid described in present embodiment provides acidic environment for chelated iodine, stabilizer can be made continuously to mend
The iodine for filling loss maintains the effective concentration of iodine, achievees the effect that permanent degerming.
The skin-rehabilitating agent containing fullerene water soluble derivatives of present embodiment is aqua, sprayable to suffer in body
Sick position, it is easy to use.
Specific embodiment 2: the difference of present embodiment and specific embodiment one or two is: the fullerene
Soluble derivative is fullerene hydroxylation derivative, fullerene aminoacid derivate, fullerene carboxylated derivative and fowler
One of alkene pyrrolidin derivatives or in which several mixtures.It is other the same as one or two specific embodiments.
Specific embodiment 3: the difference of present embodiment and one of specific embodiment one to three is: described has
Machine acid is one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixtures.Other and specific implementation
Mode one to three is identical.
Specific embodiment 4: the difference of present embodiment and one of specific embodiment one to four is: the iodine
Stabilizer is KI, NaI, KIO3And NaIO3One of or in which several mixtures.Other and specific embodiment one to four
It is identical.
Specific embodiment 5: the difference of present embodiment and one of specific embodiment one to five is: the iodine
Complexing agent is in biguanides amino-compound and hyperbranched Gemini quaternary ammonium salt amino-compound with synergic remove
One or more of mixtures.It is other identical as specific embodiment one to five.
Specific embodiment 6: the difference of present embodiment and one of specific embodiment one to six is: the table
Face activating agent is the nonionic surface active agent of fatty alcohol polyethenoxy ether class.It is other with one to six phase of specific embodiment
Together.
The nonionic surface active agent of the fatty alcohol polyethenoxy ether class of present embodiment is a kind of low bubble nonionic table
Face activating agent can form complex compound with iodine, be stable in the presence of iodine in solution.
Specific embodiment 7: the difference of present embodiment and one of specific embodiment one to seven is: the pH
Regulator is sodium bicarbonate.It is other identical as specific embodiment one to seven.
Specific embodiment 8: present embodiment be prepare specific embodiment one containing fullerene water soluble derivatives
Skin-rehabilitating agent method, be specifically realized by the following steps:
One, part pure water is taken, under conditions of continuously stirring, it is derivative that fullerene water dissolubility is sequentially added into pure water
Uniform component A is made in object, organic acid；
Two, part pure water separately is taken, under conditions of continuously stirring, iodine stabilizer, iodine is sequentially added into pure water, made
Obtain uniform B component；
Three, separately take part pure water again, under conditions of continuously stirring, sequentially added into pure water surfactant,
Uniform component C is made in iodine complexing agent；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, the dilution of remaining pure water is added to F component made from step 5, be then added pH adjusting agent adjust pH value to
5-6 is to get having arrived the skin-rehabilitating agent containing fullerene water soluble derivatives.
Part pure water described in present embodiment does not answer restricted part pure water for obtaining uniform component herein
Dosage, those skilled in the art can be weighed in right amount desired amount of pure water with common knowledge, Step 1: step 2 with
And part pure water described in step 3 is to weigh respectively, the remaining pure water in three parts of part pure water and step 6 is total
Become the pure water of surplus in specific embodiment one with group.
The content of each component in the final skin-rehabilitating agent obtained containing fullerene water soluble derivatives of present embodiment
It is consistent with the content of each component in specific embodiment one.
Fullerene water soluble derivatives described in present embodiment have anti-oxidant and cytoprotection, promote wound
Mouth healing, while the sense of discomfort as caused by cell damage can be alleviated.
Iodine described in present embodiment is the elemental iodine of solid state, is a kind of efficient, wide spectrum bacteria remover, can kill thin
The pathogen such as bacterium, brood cell, virus, bacteriophage, mycobacteria, protozoon, fungi.
Surfactant described in present embodiment can be such that iodine is stable in the presence of in solution.
Iodine complexing agent described in present embodiment serves not only as the complexing agent of iodine, moreover it is possible to increase the stabilization of iodine in the solution
Property, while synergic remove is played with iodine, and enhance the bactericidal activity of iodine.
Organic acid described in present embodiment provides acidic environment for chelated iodine, stabilizer can be made continuously to mend
The iodine for filling loss maintains the effective concentration of iodine, achievees the effect that permanent degerming.
The skin-rehabilitating agent containing fullerene water soluble derivatives that present embodiment is prepared is aqua, sprayable right
It is easy to use in body disease sites.
Specific embodiment 9: the difference of present embodiment and specific embodiment eight is: the fullerene is water-soluble
Property derivative be fullerene hydroxylation derivative, fullerene aminoacid derivate, fullerene carboxylated derivative and fullerene pyrrole
Cough up one of alkane derivatives or in which several mixtures.It is other identical as specific embodiment eight.
Specific embodiment 10: the difference of present embodiment and specific embodiment eight or nine is: the organic acid
For one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixtures.Other and specific embodiment
Eight or nine is identical.
Specific embodiment 11: the difference of present embodiment and one of specific embodiment eight to ten is: described
Iodine stabilizer is KI, NaI, KIO3And NaIO3One of or in which several mixtures.It is other with specific embodiment eight to
Ten is identical.
Specific embodiment 12: the difference of present embodiment and specific embodiment eight to one of 11 is: described
Iodine complexing agent be biguanides amino-compound and hyperbranched Gemini quaternary ammonium salt amino chemical combination with synergic remove
The mixture of one or more of object.It is other identical as specific embodiment eight to 11.
Specific embodiment 13: the difference of present embodiment and specific embodiment eight to one of 12 is: described
Surfactant be fatty alcohol polyethenoxy ether class nonionic surface active agent.Other and specific embodiment eight to ten
Two is identical.
The nonionic surface active agent of the fatty alcohol polyethenoxy ether class of present embodiment is a kind of low bubble nonionic table
Face activating agent can form complex compound with iodine, be stable in the presence of iodine in solution.
Specific embodiment 14: the difference of present embodiment and specific embodiment eight to one of 13 is: described
PH adjusting agent be sodium bicarbonate.It is other identical as specific embodiment eight to 13.
Specific embodiment 15: the difference of present embodiment and specific embodiment one is: water-soluble containing fullerene
The skin-rehabilitating agent of property derivative, it further includes the gel preparation of 0.1-1.5% (W/V).
The skin-rehabilitating agent containing fullerene water soluble derivatives of present embodiment, it is specifically included: 0.02-0.1%
(W/V) fullerene water soluble derivatives, the iodine of 0.01-0.02% (W/V), the iodine stabilizer of 0.02-0.04% (W/V),
The iodine complexing agent of 0.02-0.04% (W/V), the surfactant of 0.6-0.8% (W/V), 0.01-0.03%'s (W/V) is organic
Acid, the pH adjusting agent of 0.01-0.03% (W/V), the gel preparation of 0.1-1.5% (W/V) and the pure water of surplus.
Fullerene water soluble derivatives described in present embodiment have anti-oxidant and cytoprotection, promote wound
Mouth healing, while the sense of discomfort as caused by cell damage can be alleviated.
Iodine described in present embodiment is the elemental iodine of solid state, is a kind of efficient, wide spectrum bacteria remover, can kill thin
The pathogen such as bacterium, brood cell, virus, bacteriophage, mycobacteria, protozoon, fungi.
Surfactant described in present embodiment can be such that iodine is stable in the presence of in solution.
Iodine complexing agent described in present embodiment serves not only as the complexing agent of iodine, moreover it is possible to increase the stabilization of iodine in the solution
Property, while synergic remove is played with iodine, and enhance the bactericidal activity of iodine.
Organic acid described in present embodiment provides acidic environment for chelated iodine, stabilizer can be made continuously to mend
The iodine for filling loss maintains the effective concentration of iodine, achievees the effect that permanent degerming.
Gel preparation described in present embodiment can provide the microenvironment for promoting healing for lesions position, lock moisture,
Completely cut off outside contamination.
The skin-rehabilitating agent containing fullerene water soluble derivatives of present embodiment is gel preparation, be can be applied in body
Disease sites, it is easy to use.
Specific embodiment 16: the difference of present embodiment and specific embodiment 15 is: the fullerene
Soluble derivative is fullerene hydroxylation derivative, fullerene aminoacid derivate, fullerene carboxylated derivative and fowler
One of alkene pyrrolidin derivatives or in which several mixtures.It is other identical as specific embodiment 15.
Specific embodiment 17: the difference of present embodiment and specific embodiment 15 or 16 is: described
Organic acid is one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixtures.Other and specific reality
It is identical to apply mode 15 or 16.
Specific embodiment 18: the difference of present embodiment and specific embodiment 15 to one of 17 is: institute
The iodine stabilizer stated is KI, NaI, KIO3And NaIO3One of or in which several mixtures.Other and specific embodiment
15 to 17 is identical.
Specific embodiment 19: the difference of present embodiment and specific embodiment 15 to one of 18 is: institute
The iodine complexing agent stated is biguanides amino-compound and hyperbranched Gemini quaternary ammonium salt amination with synergic remove
Close the mixture of one or more of object.It is other identical as specific embodiment 15 to 18.
Specific embodiment 20: the difference of present embodiment and specific embodiment 15 to one of 19 is: institute
The surfactant stated is the nonionic surface active agent of fatty alcohol polyethenoxy ether class.Other and specific embodiment 15
It is identical to 19.
The nonionic surface active agent of the fatty alcohol polyethenoxy ether class of present embodiment is a kind of low bubble nonionic table
Face activating agent can form complex compound with iodine, be stable in the presence of iodine in solution.
Specific embodiment 21: the difference of present embodiment and specific embodiment 15 to one of 20 is:
The pH adjusting agent is sodium bicarbonate.It is other identical as specific embodiment 15 to 20.
Specific embodiment 22: the difference of present embodiment and specific embodiment 15 to one of 21
Be: the gel preparation is one of sodium alginate, hyaluronic acid, gelatin, yellow glue original, allantoin amino acid and Aloe Vera Gel
Or in which several mixture.It is other identical as specific embodiment 15 to 21.
Specific embodiment 23: present embodiment be prepare specific embodiment 15 containing fullerene water dissolubility
The method of the skin-rehabilitating agent of derivative, is specifically realized by the following steps:
One, part pure water is taken, under conditions of continuously stirring, it is derivative that fullerene water dissolubility is sequentially added into pure water
Uniform component A is made in object, organic acid；
Two, part pure water separately is taken, under conditions of continuously stirring, iodine stabilizer, iodine is sequentially added into pure water, made
Obtain uniform B component；
Three, separately take part pure water again, under conditions of continuously stirring, sequentially added into pure water surfactant,
Uniform component C is made in iodine complexing agent；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, under conditions of continuously stirring, gel preparation is added to F component made from step 5, is uniformly mixed, is made even
The gel component of phase；Then remaining pure water dilution is added into gel component, adds pH adjusting agent and adjusts pH value
To 5-6 to get having arrived the skin-rehabilitating agent containing fullerene water soluble derivatives.
Part pure water described in present embodiment does not answer restricted part pure water for obtaining uniform component herein
Dosage, those skilled in the art can be weighed in right amount desired amount of pure water with common knowledge, Step 1: step 2 with
And part pure water described in step 3 is to weigh respectively, the remaining pure water in three parts of part pure water and step 6 is total
Become the pure water of surplus in specific embodiment 15 with group.
The content of each component in the final skin-rehabilitating agent obtained containing fullerene water soluble derivatives of present embodiment
It is consistent with the content of each component in specific embodiment 15.
Fullerene water soluble derivatives described in present embodiment have anti-oxidant and cytoprotection, promote wound
Mouth healing, while the sense of discomfort as caused by cell damage can be alleviated.
Iodine described in present embodiment is the elemental iodine of solid state, is a kind of efficient, wide spectrum bacteria remover, can kill thin
The pathogen such as bacterium, brood cell, virus, bacteriophage, mycobacteria, protozoon, fungi.
Surfactant described in present embodiment can be such that iodine is stable in the presence of in solution.
Iodine complexing agent described in present embodiment serves not only as the complexing agent of iodine, moreover it is possible to increase the stabilization of iodine in the solution
Property, while synergic remove is played with iodine, and enhance the bactericidal activity of iodine.
Organic acid described in present embodiment provides acidic environment for chelated iodine, stabilizer can be made continuously to mend
The iodine for filling loss maintains the effective concentration of iodine, achievees the effect that permanent degerming.
Gel preparation described in present embodiment can provide the microenvironment for promoting healing for lesions position, lock moisture,
Completely cut off outside contamination.
The skin-rehabilitating agent containing fullerene water soluble derivatives that present embodiment is prepared is gel preparation, can be applied
Body disease sites are put on, it is easy to use.
Specific embodiment 24: the difference of present embodiment and specific embodiment 23 is: the richness
Le alkene soluble derivative be fullerene hydroxylation derivative, fullerene aminoacid derivate, fullerene carboxylated derivative and
One of fulleropyrrolidine derivative or in which several mixtures.It is other identical as specific embodiment 23.
Specific embodiment 25: the difference of present embodiment and specific embodiment 23 or 24 is:
The organic acid is one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixtures.It is other with
Specific embodiment 23 or 24 is identical.
Specific embodiment 26: the difference of present embodiment and specific embodiment 23 to one of 25
Be: the iodine stabilizer is KI, NaI, KIO3And NaIO3One of or in which several mixtures.Other and specific implementation
Mode 23 to 25 is identical.
Specific embodiment 27: the difference of present embodiment and specific embodiment 23 to one of 26
Be: the iodine complexing agent is biguanides amino-compound and hyperbranched Gemini quaternary ammonium salt ammonia with synergic remove
The mixture of one or more of based compound.It is other identical as specific embodiment 23 to 26.
Specific embodiment 28: the difference of present embodiment and specific embodiment 23 to one of 27
Be: the surfactant is the nonionic surface active agent of fatty alcohol polyethenoxy ether class.Other and specific embodiment party
Formula 23 to 27 is identical.
The nonionic surface active agent of the fatty alcohol polyethenoxy ether class of present embodiment is a kind of low bubble nonionic table
Face activating agent can form complex compound with iodine, be stable in the presence of iodine in solution.
Specific embodiment 29: the difference of present embodiment and specific embodiment 23 to one of 28
Be: the pH adjusting agent is sodium bicarbonate.It is other identical as specific embodiment 23 to 28.
Specific embodiment 30: the difference of present embodiment and specific embodiment 23 to one of 29
Be: the gel preparation is one of sodium alginate, hyaluronic acid, gelatin, yellow glue original, allantoin amino acid and Aloe Vera Gel
Or in which several mixture.It is other identical as specific embodiment 23 to 29.
Each raw material mentioned in the above specific embodiment is commercially available.
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be described in further detail, the reality
It applies example for explaining only the invention, protection scope of the present invention is not constituted and limited.
Embodiment one
A kind of preparation method of skin-rehabilitating agent containing fullerene water soluble derivatives is present embodiments provided, specifically
It completes according to the following steps:
One, 200g pure water is taken, under conditions of continuously stirring, 0.5g fullerene hydroxylating is sequentially added into pure water
Derivative, 0.1g citric acid, are made uniform component A；
Two, 200g pure water separately is taken, under conditions of continuously stirring, 0.2g KI, 0.2g is sequentially added into pure water
Uniform B component is made in iodine；
Three, 200g pure water is separately taken again, and under conditions of continuously stirring, 6g fatty alcohol polyoxy is sequentially added into pure water
Ethylene ether surface active agent, 0.3g biguanides amino-compound complexing agent, are made uniform component C；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform golden yellow D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, remaining pure water is added to F component made from step 5 and is diluted to 1L, pH adjusting agent is then added and adjusts pH
Value has arrived the skin-rehabilitating agent containing fullerene water soluble derivatives to 6.
The skin-rehabilitating agent containing fullerene water soluble derivatives that the present embodiment is prepared is each in gel preparation
Constituent content: the fullerene hydroxylation derivative of 0.05% (W/V), the iodine of 0.02% (W/V), the KI of 0.02% (W/V),
The biguanides amino-compound complexing agent of 0.03% (W/V), the fatty alcohol polyoxyethylene ether surfactant of 0.6% (W/V),
The citric acid of 0.01% (W/V), a small amount of sodium bicarbonate, remaining is pure water；The pH of skin-rehabilitating agent is 6.
The skin-rehabilitating agent containing fullerene water soluble derivatives that the present embodiment is prepared is aqua, be can be used spraying
Mode body disease sites spray, it is easy to use, can not only efficiently kill the harmful microorganism on damaged skin surface, be isolated
Outside contamination builds the microenvironment for being conducive to wound healing, moreover it is possible to effectively remove a large amount of free radicals, hence it is evident that improves since cell damages
The malaise symptoms such as itch caused by bad.
Embodiment two
A kind of preparation method of skin-rehabilitating agent containing fullerene water soluble derivatives is present embodiments provided, specifically
It completes according to the following steps:
One, 200g pure water is taken, under conditions of continuously stirring, 0.5g fullerene hydroxylating is sequentially added into pure water
Derivative, 0.1g formic acid, are made uniform component A；
Two, 200g pure water separately is taken, under conditions of continuously stirring, 0.2g KI, 0.2g is sequentially added into pure water
Uniform B component is made in iodine；
Three, 200g pure water is separately taken again, and under conditions of continuously stirring, 6g fatty alcohol polyoxy is sequentially added into pure water
Ethylene ether surface active agent, 0.3g biguanides amino-compound complexing agent, are made uniform component C；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, is mixed
It closes uniformly, uniform golden yellow D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, is mixed
It closes uniformly, uniform F component is made；
Six, under conditions of continuously stirring, 1g sodium alginate is added to F component made from step 5, is uniformly mixed, is made
The brown yellow gel shape component of even phase；Then remaining pure water is added into gel component and is diluted to 1L, adds carbonic acid
Hydrogen sodium adjusts pH value and has arrived the skin-rehabilitating agent containing fullerene water soluble derivatives to 5.
The skin-rehabilitating agent containing fullerene water soluble derivatives that the present embodiment is prepared is each in gel preparation
Constituent content: the fullerene hydroxylation derivative of 0.05% (W/V), the iodine of 0.02% (W/V), the KI of 0.02% (W/V),
The biguanides amino-compound complexing agent of 0.03% (W/V), the fatty alcohol polyoxyethylene ether surfactant of 0.6% (W/V),
The formic acid of 0.01% (W/V), a small amount of sodium bicarbonate, the sodium alginate of 0.1% (W/V), remaining is pure water.
The pH for the skin-rehabilitating agent containing fullerene water soluble derivatives that the present embodiment is prepared is 5, is in brown color
Transparent gel-form liquid, there is certain viscosity.
The skin-rehabilitating agent containing fullerene water soluble derivatives that the present embodiment is prepared is gel preparation, can be in body
Body disease sites are smeared, easy to use, can not only efficiently kill the harmful microorganism on damaged skin surface, and outside contamination is isolated,
Build the microenvironment for being conducive to wound healing, moreover it is possible to effectively remove a large amount of free radicals, hence it is evident that improve as caused by cell damage
The symptoms such as itch and discomfort.
Above-described embodiment should not in any way limit the present invention, all to be obtained by the way of equivalent replacement or equivalency transform
Technical solution fall within the scope of protection of the present invention.
Claims (8)
1. the skin-rehabilitating agent containing fullerene water soluble derivatives, it is characterised in that: it is specifically included: 0.02-0.1% (W/
V fullerene water soluble derivatives), the iodine of 0.01-0.02% (W/V), the iodine stabilizer of 0.02-0.04% (W/V), 0.02-
The iodine complexing agent of 0.04% (W/V), the surfactant of 0.6-0.8% (W/V), the organic acid of 0.01-0.03% (W/V),
The pH adjusting agent of 0.01-0.03% (W/V) and the pure water of surplus；Wherein, the fullerene water soluble derivatives are richness
It strangles in alkene hydroxylation derivative, fullerene aminoacid derivate, fullerene carboxylated derivative and fulleropyrrolidine derivative
One kind or in which several mixtures；The iodine stabilizer is KI, NaI, KIO3And NaIO3One of or in which it is several
Mixture；The iodine complexing agent is biguanides amino-compound and hyperbranched Gemini quaternary ammonium with synergic remove
The mixture of one or more of salt amino-compound.
2. the preparation method of the skin-rehabilitating agent as described in claim 1 containing fullerene water soluble derivatives, feature exist
In: what the preparation method of the skin-rehabilitating agent containing fullerene water soluble derivatives specifically carried out according to the following steps:
One, take part pure water, under conditions of continuously stirring, sequentially added into pure water fullerene water soluble derivatives,
Uniform component A is made in organic acid；
Two, part pure water is taken, under conditions of continuously stirring, iodine stabilizer, iodine are sequentially added into pure water, is made uniform
B component；
Three, part pure water is taken, under conditions of continuously stirring, surfactant, iodine complexing agent are sequentially added into pure water,
Uniform component C is made；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, mixing is equal
It is even, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, mixing is equal
It is even, uniform F component is made；
Six, remaining pure water dilution is added to F component made from step 5, then addition pH adjusting agent adjusting pH value to 5-6,
The skin-rehabilitating agent containing fullerene water soluble derivatives is obtained.
3. the skin-rehabilitating agent according to claim 1 containing fullerene water soluble derivatives, it is characterised in that: it is also wrapped
Include the gel preparation of 0.1-1.5% (W/V).
4. the preparation method of the skin-rehabilitating agent as claimed in claim 3 containing fullerene water soluble derivatives, contains fowler
What the preparation method of the skin-rehabilitating agent of alkene soluble derivative specifically carried out according to the following steps:
One, take part pure water, under conditions of continuously stirring, sequentially added into pure water fullerene water soluble derivatives,
Uniform component A is made in organic acid；
Two, part pure water is taken, under conditions of continuously stirring, iodine stabilizer, iodine are sequentially added into pure water, is made uniform
B component；
Three, part pure water is taken, under conditions of continuously stirring, surfactant, iodine complexing agent are sequentially added into pure water,
Uniform component C is made；
Four, under conditions of continuously stirring, B component made from step 2 is added in component C made from step 3, mixing is equal
It is even, uniform D component is made；
Five, under conditions of continuously stirring, D component made from step 4 is added in component A made from step 1, mixing is equal
It is even, uniform F component is made；
Six, under conditions of continuously stirring, gel preparation is added to F component made from step 5, is uniformly mixed, even phase is made
Gel component；Then remaining pure water dilution is added into gel component, adds pH adjusting agent and adjusts pH value to 5-
6 to get having arrived the skin-rehabilitating agent containing fullerene water soluble derivatives.
5. the skin-rehabilitating agent according to claim 1,2 or 4 containing fullerene water soluble derivatives, it is characterised in that:
The organic acid is one of acetic acid, citric acid, tartaric acid, phosphoric acid and lactic acid or in which several mixtures.
6. the skin-rehabilitating agent according to claim 1,2 or 4 containing fullerene water soluble derivatives, it is characterised in that:
The surfactant is the nonionic surface active agent of fatty alcohol polyethenoxy ether class.
7. the skin-rehabilitating agent according to claim 1,2 or 4 containing fullerene water soluble derivatives, it is characterised in that:
The pH adjusting agent is sodium bicarbonate.
8. the skin-rehabilitating agent according to claim 3 or 4 containing fullerene water soluble derivatives, it is characterised in that: institute
The gel preparation stated be one of sodium alginate, hyaluronic acid, gelatin, xanthan gum, allantoin amino acid and Aloe Vera Gel or its
In several mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510449840.0A CN105012347B (en) | 2015-07-28 | 2015-07-28 | Skin-rehabilitating agent and preparation method thereof containing fullerene water soluble derivatives |
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| CN105012347B true CN105012347B (en) | 2019-01-01 |
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Citations (3)
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|---|---|---|---|---|
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| CN101524367A (en) * | 2009-02-19 | 2009-09-09 | 济南瑞源医药科技有限责任公司 | Method for preparing discolored iodine tincture and application thereof |
| CN102688156A (en) * | 2011-03-22 | 2012-09-26 | 天津博莱恩科技发展有限公司 | Iodine-containing gynecologic disinfection and sterilization irrigant |
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2015
- 2015-07-28 CN CN201510449840.0A patent/CN105012347B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1753968A (en) * | 2003-01-27 | 2006-03-29 | 三菱商事株式会社 | Antioxidative composition and composition for external use |
| CN101524367A (en) * | 2009-02-19 | 2009-09-09 | 济南瑞源医药科技有限责任公司 | Method for preparing discolored iodine tincture and application thereof |
| CN102688156A (en) * | 2011-03-22 | 2012-09-26 | 天津博莱恩科技发展有限公司 | Iodine-containing gynecologic disinfection and sterilization irrigant |
Non-Patent Citations (1)
| Title |
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| Liposome fullerene as a novel antioxidant for skin treatment;Takahiro Fujimoto et al.;《Chin Med J》;20121231;第152页 |
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