CN106511326A - Repairing type disinfection liquid - Google Patents
Repairing type disinfection liquid Download PDFInfo
- Publication number
- CN106511326A CN106511326A CN201611012092.0A CN201611012092A CN106511326A CN 106511326 A CN106511326 A CN 106511326A CN 201611012092 A CN201611012092 A CN 201611012092A CN 106511326 A CN106511326 A CN 106511326A
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- CN
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- Prior art keywords
- repairing type
- disinfectant solution
- percent
- solution according
- type disinfectant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to repairing type disinfection liquid capable of prompting healing of wounds. The repairing type disinfection liquid is mainly prepared from the following components in percentage: 0.01 to 2.0 percent of single and double-strand compound quaternary ammonium salts or benzethonium chloride, 0.01 to 2.0 percent of guanidine, 0.0 to 1.0 percent of modified chitosan, 2.0 to 5.0 percent of small molecular alcohol, 1.0 to 10.0 percent of skin care agent and 0.1 to 2.0 percent of anti-sensitivity agent. A plurality of single and double-strand quaternary ammonium salts are mixed synergistically, so that the sterilizing ability is enhanced; guanidine is compounded, so that the sterilizing wide spectrum is enhanced; healing and recovery of the wounds are facilitated through film formation protection performance and biocompatibility of chitosan; meanwhile, stimulation and discomfort on the wound surface can be lowered through anti-sensitivity factors. The repairing disinfection liquid can be widely applied to medical use and civil use, and has high social benefit and economic benefit.
Description
Technical field
The present invention relates to a kind of repairing type disinfectant solution for promoting wound healing, relates in particular to a kind of for surgery inflammation
The sterilizing agent for external use of wound surface.
Background technology
At present, the conventional wound surface of hospital kills becteriums product mainly ethanol, povidone iodine, chlorhexidine etc., due to single effect, past
It is used in combination or matching purge class product toward needs（Such as normal saline）Use simultaneously.Complex operation, lose time, manpower with
Material resources, while speed of wound healing is also unsatisfactory.
The content of the invention
The invention aims to overcome deficiency of the prior art, accelerate the healing rate of wound, there is provided one
Repairing type disinfectant solution is planted, the disinfectant solution can not only kill various mushrooms, and can also protect wound surface, promote wound healing.
In order to solve above-mentioned technical problem, the present invention is achieved by the following technical solutions.
A kind of repairing type disinfectant solution, by single double-strand compound quaternary ammonium salt, guanidine, shitosan, small molecular alcohol, skin protectant and Tramal
Agent is constituted, and its raw materials quality percentage ratio is：
Single double-strand compound quaternary ammonium salt or benzyl rope chloramines 0.01%～2.00%
Guanidine 0.01%～2.00%；
Modification of chitosan 0.01%～1.00%；
Small molecular alcohol 2.00%～5.00%；
Skin protectant 1.00%～10.0%；
Tramal agent 0.10%～2.00%；
Purification water surplus.
Described single double-strand compound quaternary ammonium salt is zephiran, octyl decyl dimethyl ammonium chloride, double
One or more mixture in eight alkyl dimethyl ammonium chlorides, didecyl Dimethy ammonium chloride.
Described guanidine be chlorhexidine acetate, chlorhexidine gluconate, poly hexamethylene biguanide, in polyaminopropyl biguanide salt
One or more mixture.
Modified soluble shitosan of the described modification of chitosan for small molecule.
Described small molecular alcohol is ethanol, isopropanol, Propylene Glycol, one or more mixture in butanediol.
Described skin protectant is glycerol, lightweight Dormant oils, one or more mixture in silicone oil.
Described Tramal agent is plant extraction liquid, one or two mixture in lignocaine.
Mixed using the collaboration of various single double-chain quaternary ammonium salts, strengthen the ability for killing antibacterial, while compounding has well killing
The guanidine of fungus killing effect, improves sterilizing broad spectrum activity.Early stage is theoretical using moist wounds, sets up initial stage wound healing condition；Afterwards
Phase recovers by the film forming protectiveness of chitosan biological molecule and the healing of biocompatibility promotion wound；At the same time Tramal
The factor can also reduce stimulation and the sense of discomfort of wound surface.
The present invention manufacture method be：
1. modification of chitosan is added in small molecular alcohol, stirring and dissolving；
2. single double chain cationic quaternary ammonium salt and biguanides disinfectant is added after adding partial purification water, mixes dissolving；
3. skin protectant, Tramal agent is sequentially added, and adds purified water to after 100%, stirring and dissolving obtains final product the repairing type to uniform
Disinfectant solution.
The invention has the beneficial effects as follows, while quick killing wound surface various bacterium can form Wound surface protection film, reduce
Stimulate sense of discomfort, and accelerate the healing of wound.Multiple-effect is unified, easy to use, settles at one go.
Specific embodiment
The present invention is described in further detail with reference to specific embodiment.
Embodiment 1：
Zephiran 0.10%；
Octyl decyl dimethyl ammonium chloride 0.10%；
Double eight alkyl dimethyl ammonium chlorides 0.10%；
Didecyl Dimethy ammonium chloride 0.10%；
Poly hexamethylene biguanide 0.80%；
Modification of chitosan 0.05%；
Propylene Glycol 3.00%；
Glycerol 5.00%；
Plant extraction liquid 0.50%；
Purification water surplus.
Compound method：Modification of chitosan is added in small molecular alcohol, stirring and dissolving；Purified water is subsequently adding, and is added
Single double-strand compound quaternary ammonium salt and biguanide constituents, mix dissolving；Propylene Glycol, glycerol, plant extraction liquid is sequentially added, most
Afterwards plus purified water is to after 100%, stirring and dissolving obtains final product the repairing type disinfectant solution to uniform.
Embodiment 2：
Benzyl rope chloramines 0.80%；
Chlorhexidine gluconate 1.00%；
Modification of chitosan 1.00%；
Ethanol 3.00%；
Lightweight Dormant oils 1.00%；
Lignocaine 0.10%；
Purification water surplus.
Compound method：Preparation method is with embodiment 1.
The preferably feasible embodiment of the above-mentioned only present invention, the non-therefore limitation scope of the present invention, according to above-described embodiment
Made various modifications are applied mechanically within this technical scheme protection domain.
Claims (7)
1. a kind of repairing type disinfectant solution, it is characterised in that by single double-strand compound quaternary ammonium salt, biguanide, shitosan, small molecular alcohol, skin protection
Agent and Tramal agent are constituted, and its raw materials quality percentage ratio is：
Single double-strand compound quaternary ammonium salt or benzyl rope chloramines 0.01%～2.00%
Guanidine 0.01%～2.00%；
Modification of chitosan 0.01%～1.00%；
Small molecular alcohol 2.00%～5.00%；
Skin protectant 1.00%～10.0%；
Tramal agent 0.10%～2.00%；
Purification water surplus.
2. repairing type disinfectant solution according to claim 1, it is characterised in that described single double-strand compound quaternary ammonium salt is alkyl
Dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, double eight alkyl dimethyl ammonium chlorides, didecyl Dimethy chlorination
One or more mixture in ammonium.
3. repairing type disinfectant solution according to claim 1, it is characterised in that described guanidine is chlorhexidine acetate, Fructus Vitis viniferae
One or more mixture in saccharic acid chlorhexidine, poly hexamethylene biguanide, polyaminopropyl biguanide salt.
4. repairing type disinfectant solution according to claim 1, it is characterised in that described modification of chitosan changes for small molecule
Property water-soluble chitosan.
5. repairing type disinfectant solution according to claim 1, it is characterised in that described small molecular alcohol be ethanol, isopropanol,
Propylene Glycol, one or more mixture in butanediol.
6. repairing type disinfectant solution according to claim 1, it is characterised in that described skin protectant is glycerol, lightweight ore deposit
One or more mixture in oil, silicone oil.
7. repairing type disinfectant solution according to claim 1, it is characterised in that described Tramal agent is plant extraction liquid, profit
One or two mixture in many caines.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012092.0A CN106511326A (en) | 2016-11-17 | 2016-11-17 | Repairing type disinfection liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611012092.0A CN106511326A (en) | 2016-11-17 | 2016-11-17 | Repairing type disinfection liquid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106511326A true CN106511326A (en) | 2017-03-22 |
Family
ID=58352174
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611012092.0A Pending CN106511326A (en) | 2016-11-17 | 2016-11-17 | Repairing type disinfection liquid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106511326A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714501A (en) * | 2017-10-24 | 2018-02-23 | 山东新华医疗器械股份有限公司 | One kind is without alcohol foam hand sanitizing fluid |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
| CN109699693A (en) * | 2019-01-22 | 2019-05-03 | 江西乐丰医疗科技股份有限公司 | A kind of chitosan compound disinfectant |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104248776A (en) * | 2014-09-03 | 2014-12-31 | 枝江奥美医疗用品有限公司 | Antibiosis solution used for dressing, antibiosis dressing and preparation method for antibiosis dressing |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
-
2016
- 2016-11-17 CN CN201611012092.0A patent/CN106511326A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104248776A (en) * | 2014-09-03 | 2014-12-31 | 枝江奥美医疗用品有限公司 | Antibiosis solution used for dressing, antibiosis dressing and preparation method for antibiosis dressing |
| CN104644667A (en) * | 2015-02-12 | 2015-05-27 | 天津大学 | Compound disinfectant and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 张西园等: "《你不可不知的100种皮肤保养秘诀》", 31 January 2010, 江苏科学技术出版社 * |
| 陈旭素等: "《麻醉科护理基本知识与技术》", 31 January 2015, 人民军医出版社 * |
| 陈锦珊等: "《新编护士用药指南》", 31 October 2013, 中国医药科技出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714501A (en) * | 2017-10-24 | 2018-02-23 | 山东新华医疗器械股份有限公司 | One kind is without alcohol foam hand sanitizing fluid |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
| CN109699693A (en) * | 2019-01-22 | 2019-05-03 | 江西乐丰医疗科技股份有限公司 | A kind of chitosan compound disinfectant |
| CN113136040A (en) * | 2021-05-08 | 2021-07-20 | 中国科学院华南植物园 | Cationic starch gel and preparation method and application thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170322 |
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