CN101780016A - Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof - Google Patents

Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof Download PDF

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CN101780016A
CN101780016A CN 200910045463 CN200910045463A CN101780016A CN 101780016 A CN101780016 A CN 101780016A CN 200910045463 CN200910045463 CN 200910045463 CN 200910045463 A CN200910045463 A CN 200910045463A CN 101780016 A CN101780016 A CN 101780016A
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chlorine dioxide
cetylpyridinium chloride
compound formula
zinc
distilled water
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CN 200910045463
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Chinese (zh)
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CN101780016B (en )
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冯希平
叶玮
李允武
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上海交通大学医学院附属第九人民医院
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Abstract

The invention relates to compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and a preparation method thereof. The compound formula mouth wash comprises the following main raw materials: chlorine dioxide, cetylpyridinium chloride and zinc ions, wherein a solvent is distilled water; the concentration of the chlorine dioxide is 200-500 ppm; the cetylpyridinium chloride accounts for the mass fraction of 0.05-0.2 percent relative to the compound formula mouth wash; and the zinc ions accounts for the mass fraction of 0.5-1 percent relative to the compound formula mouth wash. The preparation method of the compound formula mouth wash comprises the following steps of: dissolving the cetylpyridinium chloride and zinc acetate into the distilled water; dissolving a menthol crystal into 95 percent of ethanol; adding a menthol crystal and ethanol solution to a water solution for stirring, and simultaneously adding glycerol; additionally dissolving chlorine dioxide powder into the distilled water; adding a chlorine dioxide water solution to the water solution while stirring; uniformly stirring, and adding the distilled water to obtain the compound formula mouth wash of the chlorine dioxide, the cetylpyridinium chloride and the zinc ions. The invention can effectively inhibit bromopnea for a long time and has fewer side effects and no obvious irritation on an oral mucosa.

Description

二氧化氯、西吡氯铵和锌离子复合配方漱口水及其制备方 Chlorine dioxide, cetylpyridinium chloride, zinc ion compound and the preparation thereof mouthwash formulation

law

【技术领域】 TECHNICAL FIELD

[0001] 本发明涉及漱口水技术领域,具体地说,是一种二氧化氯、西吡氯铵和锌离子复合 [0001] The present invention relates to mouthwash technical field, in particular, a chlorine dioxide, cetylpyridinium chloride, zinc ion compound and

配方漱口水及其制备方法。 Mouthwash formulation and preparation method. 【背景技术】 【Background technique】

[0002] 口气是一种常见的口腔症状,由口腔内外的一系列因素所引起,但在大多数情况下,口气起源于口腔本身,归因于口腔内厌氧菌在厌氧条件下代谢氨基酸产生一系列产物, 主要成分为挥发性硫化物气体。 [0002] breath is a common oral symptoms, caused by a series of factors both inside and outside of the mouth, but in most cases, the tone originated in the mouth itself, due to the anaerobic metabolism of amino acids under anaerobic conditions in the mouth produce a series of products, the main component of volatile sulfide gas. 目前对口气的治疗药物主要有两类,首先是能减少口腔内厌氧菌数量的药物,常用的有具备抑菌效果的氯己定、甲硝唑、西吡氯铵,三氯羟苯醚等;其 Drugs currently two main types of tone, the first is to reduce the number of oral anaerobes drugs commonly used have antibacterial effect of chlorhexidine, metronidazole, cetylpyridinium chloride, chlorobutanol hydroxybenzyl ether and so on; it

次是能将口气中的挥发性硫化物气体转化为非挥发性物质的药物,比如二氧化氯、锌离子、 过氧化氢等。 Secondary gas is able to breath volatile sulfur compounds into non-volatile substances in the pharmaceutical, such as chlorine dioxide, zinc ions, hydrogen peroxide and the like. 临床实验证实,上述药物均能在一定程度上减轻口气。 Clinical trials demonstrated that these drugs could reduce the tone to some extent. 具备抑菌效果的药物如氯己定、甲硝唑等虽有一定疗效,但长期应用可破坏口腔的生态平衡,并且易使细菌产生耐药性,因而不能长期使用。 The inhibitory effect of the drugs have a certain effect, although chlorhexidine, metronidazole, but long-term use can destroy the ecological balance of the mouth, and easy to make bacteria resistant, long-term use and therefore can not. 而使用能将口气中的挥发性硫化物气体转化为非挥发性物质的药物,比如二氧化氯、锌离子、过氧化氢等,只能在短时间内减轻口气,停止使用后4小时以内口气会反弹。 After gas volatile sulfur compounds can be used in the tone medicament into non-volatile substances, such as chlorine dioxide, zinc ions, hydrogen peroxide, etc., can reduce the tone in a short time, stop using tone 4 hours It will rebound. 因此,研究一种长久高效去除口气的漱口水成为研究的热点问题之一。 Therefore, Study of a long-term efficient removal of mouthwash breath become one of the hot topics.

【发明内容】 [SUMMARY]

[0003] 本发明的目的在于克服现有技术的不足,提供一种二氧化氯、西吡氯铵和锌离子复合配方漱口水及其制备方法。 [0003] The object of the present invention is to overcome the disadvantages of the prior art, there is provided a chlorine dioxide, cetylpyridinium chloride, zinc ion compound and mouthwash formulation and preparation method.

[0004] 本发明的目的是通过以下技术方案来实现的: [0004] The object of the present invention is achieved by the following technical solution:

[0005] —种二氧化氯、西吡氯铵和锌离子复合配方漱口水,其原料主要成份为二氧化氯, 西吡氯铵以及锌离子,辅料为薄荷脑,糖精钠,95%乙醇,甘油;西吡氯铵占复合配方漱口水的质量分数为0. 05〜0. 2% ,锌离子占复合配方漱口水的质量分数为0. 5〜1 % , 二氧化氯占复合配方漱口水的质量分数为200〜500mg/L,薄荷脑占复合配方漱口水的质量分数为0. 4g/L,糖精钠占复合配方漱口水的质量分数为0. 3g/L,乙醇占复合配方漱口水的体积分数为60ml/L,甘油占复合配方漱口水的体积分数为80ml/L,余量为蒸馏水;锌离子选自醋酸锌或者柠檬酸锌中的一种;二氧化氯浓度为200〜500卯m ; [0005] - species of chlorine dioxide, cetylpyridinium chloride, zinc ion compound and mouthwash formulations, the raw material for the main component chlorine dioxide, cetylpyridinium chloride, and zinc ions, accessories for menthol, sodium saccharin, 95% ethanol, glycerol; cetylpyridinium chloride compound formula representing mouthrinse 0. 05~0 mass fraction of 2%, a zinc ion compound formula representing mouthrinse 5~1 mass fraction of 0.5%, representing a composite chlorine dioxide mouthwash formulation. the mass fraction of 200~500mg / L, menthol mouthwash compound formula representing the mass fraction of 0. 4g / L, sodium saccharin compound formula representing mouthrinse mass fraction of 0. 3g / L, ethanol comprises mouthwash compound formula the volume fraction of 60ml / L, glycerol compound formula accounting mouthwash volume fraction of 80ml / L, the balance is distilled water; zinc ion is selected from zinc acetate or zinc citrate; a chlorine dioxide concentration of 200~500 d m;

[0006] 其制备方法的具体步骤为,将西吡氯铵和醋酸锌溶于蒸馏水中,薄荷脑溶于95% [0006] The specific steps of the method of preparation, the cetylpyridinium chloride and zinc acetate dissolved in distilled water, dissolved in 95% menthol

乙醇中,将薄荷脑乙醇液加入水溶液中搅拌,同时加入甘油;另取二氧化氯粉末溶于蒸馏水 Ethanol, menthol ethanol was added to the aqueous solution was stirred while adding glycerol; Another chlorine dioxide powder was dissolved in distilled water

中,将二氧化氯水溶液加入水溶液中,边加边搅拌,混匀并加入蒸馏水,得到二氧化氯、西吡 , The aqueous chlorine dioxide was added an aqueous solution, with stirring, mixed and distilled water was added to give a chlorine dioxide, cetylpyridinium

氯铵和锌离子复合配方漱口水。 Chloride ions and zinc complexes mouthwash formulation.

[0007] 与现有技术相比,本发明的积极效果是: [0007] Compared with the prior art, the positive effect of the invention is:

[0008] 二氧化氯属于过氧化物类消毒剂,通过直接氧化口气中的挥发性硫化物使之成为无味产物从而抑制口气,含二氧化氯的漱口液在含漱后可明显降低口气程度,西吡氯铵属阳离子表面活性剂,能引起细胞膜紊乱,达到抑菌的功效进而减轻口气,用含西吡氯铵的含漱液每天3〜4次漱口,可使牙菌斑的形成降低30% ;锌离子能降低牙菌斑中细菌的代谢活性,达到抑制菌斑的效果,而且可通过与唾液中的钙离子进行置换,与羧基、磷酸盐等物质结合,得以在口腔内长久滞留,获得缓慢持久的释放。 [0008] Peroxide disinfectant chlorine dioxide belongs, making tasteless product by direct oxidation of volatile sulfur compounds in breath tone is suppressed, mouthwashes containing chlorine dioxide can significantly reduce the level of tone in the rinse , cetylpyridinium chloride mouthrinse metal cation surfactant, can cause cell membrane disruption, and thus reduce the inhibitory effect reaches tone, cetylpyridinium chloride containing 3 to 4 times a day, mouthwash, dental plaque can be formed reduced by 30%; zinc ions reduce the metabolic activity of plaque bacteria, to achieve the effect of suppressing plaque, but also, in combination with a carboxyl group, phosphate and other substances by the substitution of calcium ions in the saliva, in the oral cavity may be long retention, get a slow and sustained release.

[0009] 本发明综合二氧化氯极强的氧化作用、西吡氯铵良好的抗菌效果和锌离子能在口腔内长久滞留,缓慢持久释放的优点,将上述三种药物组合成复方制剂,达到长久有效抑制口气的效果。 [0009] Integrated chlorine dioxide oxidation of the present invention is extremely good antimicrobial effect cetylpyridinium chloride and zinc ions can be retained in the mouth for a long time, the advantages of a slow sustained release of the pharmaceutical composition into the three compound preparation, to long-term effective inhibitory effect tone.

[0010] 二氧化氯、西吡氯铵和锌离子不属于抗生素,长期使用不会破坏口腔菌群平衡,而且副作用较小,对口腔黏膜无明显剌激性,临床试验证实,用复合配方漱口水漱口后,3小时内口气值减少了93 % ,并且在8〜10小时后仍然有效,将口气值控制在较低的水平。 [0010] chlorine dioxide, cetylpyridinium chloride and zinc ions are not antibiotics, will not damage the long-term use of oral flora balance and fewer side effects, no irritation to the oral mucosa, clinical trials, rinse with a compound formula after mouth saliva, over 3 hours to reduce the tone value of 93%, and is still valid after 8~10 hours, the value of the control tone at a lower level.

【具体实施方式】 【detailed description】

[0011] 以下提供本发明二氧化氯、西吡氯铵和锌离子复合配方漱口水及其制备方法的具 [0011] In the following the present invention to provide chlorine dioxide, cetylpyridinium chloride, zinc ion compound and mouthwash formulations and methods of making water having

体实施方式。 According to the embodiment.

[0012] 实施例1 [0012] Example 1

[0013] 原料为西吡氯铵、醋酸锌、二氧化氯为主要成份,辅料为薄荷脑、95%乙醇、甘油、 蒸馏水、糖精钠。 [0013] The feedstock is cetylpyridinium chloride, zinc acetate, chlorine dioxide as a main component, materials menthol, 95% ethanol, glycerine, distilled water, sodium saccharin.

[0014] 精密称取O. 5g西吡氯铵、2. 5g醋酸锌和0. 15g糖精钠,溶于约300ml蒸馏水中, 另称取0. 2g薄荷脑溶于30ml 95%乙醇中,将薄荷脑乙醇液加入水溶液中搅拌,同法加入40ml甘油;另精密称取2. 86g 二氧化氯粉末,溶于约80ml蒸馏水中,将二氧化氯水溶液加入水溶液中,边加边搅拌,混匀,加入蒸馏水至500ml,混匀即得到复合配方漱口水。 [0014] Accurately weighed O. 5g cetylpyridinium chloride, 2. 5g zinc acetate and sodium saccharin 0. 15g, was dissolved in about 300ml of distilled water, the other weighed 0. 2g menthol dissolved in 30ml 95% ethanol, the menthol was added to the aqueous solution of ethanol was stirred, the same method was added 40ml of glycerol; 2. 86g accurately weighed another chlorine dioxide powder was dissolved in about 80ml distilled water, aqueous chlorine dioxide was added an aqueous solution, with stirring, mix distilled water was added to 500ml, and mix to obtain a composite mouthwash formulation. [0015] 实施例2 [0015] Example 2

[0016] 原料为西吡氯铵、醋酸锌、二氧化氯为主要成份,辅料为薄荷脑、95%乙醇、甘油、 蒸馏水。 [0016] The feedstock is cetylpyridinium chloride, zinc acetate, chlorine dioxide as a main component, materials menthol, 95% ethanol, glycerin, distilled water.

[0017] 精密称取0. 5g西吡氯铵和2. 5g醋酸锌,溶于约300ml蒸馏水中,另称取0. 2g薄荷脑溶于30ml 95%乙醇中,将薄荷脑乙醇液加入水溶液中搅拌,同法加入40ml甘油;另精密称取2. lg 二氧化氯粉末,溶于约80ml蒸馏水中,将二氧化氯水溶液加入水溶液中,边加边搅拌,混匀,加入蒸馏水至500ml ,混匀即得到复合配方漱口水。 [0017] Accurately weighed 0. 5g cetylpyridinium chloride, zinc acetate and 2. 5g, was dissolved in about 300ml of distilled water, the other weighed 0. 2g menthol dissolved in 30ml 95% ethanol, and ethanol was added to an aqueous solution of menthol stirring, the same method was added 40ml of glycerol; 2. lg accurately weighed another chlorine dioxide powder was dissolved in about 80ml distilled water, aqueous chlorine dioxide was added an aqueous solution, with stirring, mixing, distilled water was added to 500ml, kneading to obtain a composite mouthwash formulation.

[0018] 以上所述仅是本发明的优选实施方式,应当指出,对于本技术领域的普通技术人员,在不脱离本发明构思的前提下,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围内。 [0018] The above are only preferred embodiments of the present invention, it should be noted that for those of ordinary skill in the art, without departing from the inventive concept premise, can make various improvements and modifications, improvements and modifications of these also it is considered within the scope of the present invention.

4 4

Claims (4)

  1. 一种二氧化氯、西吡氯铵和锌离子复合配方漱口水,其特征在于,其原料主要成份为二氧化氯,西吡氯铵以及锌离子,辅料为薄荷脑,糖精钠,乙醇,甘油;西吡氯铵占复合配方漱口水的质量分数为0.05~0.2%,锌离子占复合配方漱口水的质量分数为0.5~1%,二氧化氯占复合配方漱口水的质量分数为200~500mg/L,薄荷脑占复合配方漱口水的质量分数为0.4g/L,糖精钠占复合配方漱口水的质量分数为0.3g/L,乙醇占复合配方漱口水的体积分数为60ml/L,甘油占复合配方漱口水的体积分数为80ml/L,余量为蒸馏水。 One of chlorine dioxide, cetylpyridinium chloride, zinc ion compound and mouthwash formulations, characterized in that the main ingredients of the raw material chlorine dioxide, cetylpyridinium chloride, and zinc ions, accessories for menthol, sodium saccharin, ethanol, glycerol ; cetylpyridinium chloride compound formula representing mouthrinse mass fraction of 0.05% to 0.2%, zinc ion compound formula representing mouthrinse mass fraction of 0.5 to 1% of chlorine dioxide complex formula representing mouthrinse mass fraction of 200 ~ 500mg / L, menthol mouthwash compound formula representing a mass fraction of 0.4 g of / L, sodium saccharin compound formula representing mouthrinse mass fraction of 0.3 g of / L, ethanol mouthwash formulation accounting composite volume fraction of 60ml / L, glycerol accounting compound formula mouthwash volume fraction of 80ml / L, the balance being distilled water.
  2. 2. 如权利要求1所述的二氧化氯、西吡氯铵和锌离子复合配方漱口水,其特征在于,所述的锌离子选自醋酸锌或者柠檬酸锌中的一种。 2. The chlorine dioxide according to claim 1, cetylpyridinium chloride, zinc ion compound and mouthwash formulations, wherein the zinc ion is selected from zinc acetate or zinc citrate of.
  3. 3. 如权利要求1所述的二氧化氯、西吡氯铵和锌离子复合配方漱口水,其特征在于,所述的二氧化氯浓度为200〜500卯m。 Said chlorine dioxide as claimed in claim 1, cetylpyridinium chloride, zinc ion compound and mouthwash formulations, characterized in that the chlorine dioxide concentration of 200~500 d m.
  4. 4. 如权利要求1所述的二氧化氯、西吡氯铵和锌离子复合配方漱口水的制备方法,其特征在于,其具体步骤为:将西吡氯铵和醋酸锌溶于蒸馏水中,薄荷脑溶于乙醇中,将薄荷脑乙醇液加入水溶液中搅拌,同时加入甘油;另取二氧化氯粉末溶于蒸馏水中,将二氧化氯水溶液加入水溶液中,边加边搅拌,混匀并加入蒸馏水,得到二氧化氯、西吡氯铵和锌离子复合配方漱口水。 4. The chlorine dioxide according to claim 1, preparation method of cetylpyridinium chloride and zinc ion compound formula mouthwash, wherein, the specific steps of: cetylpyridinium chloride and zinc acetate dissolved in distilled water, menthol dissolved in ethanol, menthol ethanol was added to the aqueous solution was stirred while adding glycerol; another chlorine dioxide powder was dissolved in distilled water, aqueous chlorine dioxide was added an aqueous solution, with stirring, was added and mixed distilled water to obtain chlorine dioxide, cetylpyridinium chloride, zinc ion compound and mouthwash formulations.
CN 200910045463 2009-01-16 2009-01-16 Compound formula mouth wash of chlorine dioxide, cetylpyridinium chloride and zinc ion and preparation method thereof CN101780016B (en)

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Cited By (4)

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CN102008399A (en) * 2010-12-22 2011-04-13 韶关蓝威消毒药业有限公司 Preparation method of antimicrobial mouthwash
CN102441006A (en) * 2011-12-01 2012-05-09 刘学武 Hair-regrowth solution containing chlorine dioxide, and preparation and application method thereof
US9044466B2 (en) 2010-08-07 2015-06-02 The Research Foundation For The State University Of New York Oral compositions comprising a zinc compound and an anti-microbial agent
CN106109366A (en) * 2016-08-30 2016-11-16 南京巨鲨显示科技有限公司 Mouthwash and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6723305B2 (en) 2002-03-04 2004-04-20 Colgate Palmolive Company Anti-microbial breath freshening mouthrinse
US7803353B2 (en) 2006-03-29 2010-09-28 The Procter & Gamble Company Oral care compositions having improved consumer aesthetics and taste

Cited By (10)

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Publication number Priority date Publication date Assignee Title
US9480635B2 (en) 2010-08-07 2016-11-01 The Research Foundation For The State University Of New York Compositions and methods of reducing dry mouth
US9044466B2 (en) 2010-08-07 2015-06-02 The Research Foundation For The State University Of New York Oral compositions comprising a zinc compound and an anti-microbial agent
US9138428B2 (en) 2010-08-07 2015-09-22 The Research Foundation For The State University Of New York Oral compositions comprising a zinc compound and an anti-microbial agent
RU2581915C2 (en) * 2010-08-07 2016-04-20 Дзе Рисерч Фаундейшн Фор Дзе Стейт Юниверсити Оф Нью Йорк Oral care composition containing compound of zinc and antimicrobial agent
US10071031B2 (en) 2010-08-07 2018-09-11 The Research Foundation For The State University Of New York Methods for reducing oral malodor in non-human animals
CN102008399A (en) * 2010-12-22 2011-04-13 韶关蓝威消毒药业有限公司 Preparation method of antimicrobial mouthwash
CN102008399B (en) 2010-12-22 2013-06-12 韶关蓝威消毒药业有限公司 Preparation method of antimicrobial mouthwash
CN102441006B (en) * 2011-12-01 2016-06-01 刘学武 Germinal method of making and using a solution containing chlorine dioxide
CN102441006A (en) * 2011-12-01 2012-05-09 刘学武 Hair-regrowth solution containing chlorine dioxide, and preparation and application method thereof
CN106109366A (en) * 2016-08-30 2016-11-16 南京巨鲨显示科技有限公司 Mouthwash and preparation method thereof

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