CN103735568A - Compound guanidine complex iodine skin mucosa disinfectant and preparation method thereof - Google Patents
Compound guanidine complex iodine skin mucosa disinfectant and preparation method thereof Download PDFInfo
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- CN103735568A CN103735568A CN201310697958.6A CN201310697958A CN103735568A CN 103735568 A CN103735568 A CN 103735568A CN 201310697958 A CN201310697958 A CN 201310697958A CN 103735568 A CN103735568 A CN 103735568A
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Abstract
The invention relates to a compound guanidine complex iodine skin mucosa disinfectant and a preparation method thereof. The compound guanidine complex iodine skin mucosa disinfectant comprises the following components in percentage by weight: 0.1-0.3% of guanidine disinfectant, 0.5-1% of complex iodine (based on the effective iodine content), 5-20% of solubilizer, 1-10% of cosolvent, 0.05-0.2% of citric acid, 0.5-3% of skin care agent and the balance of purified water. The preparation method of the compound guanidine complex iodine skin mucosa disinfectant comprises the following steps: adding the latent solvent and the cosolvent into one part of the purified water according to the content and components, and heating and stirring for dissolution; sequentially adding the complex iodine, the skin care agent and the citric acid, and stirring for dissolution; adding the guanidine disinfectant, mixing and stirring uniformly; adding the purified water to 100%, and stirring uniformly to obtain the compound guanidine complex iodine skin mucosa disinfectant. The compound guanidine complex iodine skin mucosa disinfectant has the characteristics of stable properties, fast and lasting sterilization effect and no irritation to the skin, mucosa and wound, and is convenient to use.
Description
Technical field
The present invention relates to disinfectant, be specifically related to a kind of compound recipe guanidine class chelated iodine skin mucosa disinfectant solution and preparation method thereof.
Background technology
Guanidine class is a kind of wide spectrum, quick-acting bactericide, by destroying the permeability barrier on antibacterial endochylema film, fatty acid in cell membrane phospholipid is combined, puncture rapidly their cytoplasma membrane, cellular content is spilt, low concentration can cause part endochylema seepage, and high concentration can cause endochylema cohesion degeneration, thereby reaches bactericidal effect.Its advantage be zest compared with other externally used antimicrobial agent be low, seldom there is anaphylactic reaction, combine use with other antibacterial, can bring into play splendid Disinfection Effect.Because guanidine class disinfectant has a kind of unspecific sterilization mode, therefore its probability that produces Resistant strain is very little.
Chelated iodine is a kind of powerful disinfectant of wide spectrum, and virus, antibacterial, fungus and mycotic spore are had to stronger killing action, and it discharges gradually iodine in solvent, plays a kind of slow releasing function, to keep the sterilizing power of long period.But its sterilization speed is slow, clinical use has limitation.
Because guanidine class and iodine can generate a kind of molecular link compound that is insoluble in water, the composite disinfectant of common guanidine class and iodine is conventionally with 45%～75% ethanol or mixed organic solvents dissolved dilution on the market, because high concentration ethanol or organic solvent have larger stimulation to skin, mucosa, wound and wound surface, limited the scope of application of this disinfectant.
summary of the invention
The present invention is intended to the shortcoming of customer service folk prescription disinfectant, the compound disinfectant that utilizes multicomponent to form, expand antimicrobial spectrum, prevent the generation of Resistant strain, utilize the solubilization of solubilizing agent simultaneously, reduce the content of ethanol or other organic solvents, make it have not irritates nucous membrane and wound, quick-acting, long-acting, the feature that can indicate sterilising zone, can be for the sterilization of skin, mucosa, wound and wound surface.
A kind of compound recipe guanidine class chelated iodine skin mucosa disinfectant solution, it comprises the component of following each percetage by weight:
Guanidine class, 0.1-0.6;
Chelated iodine (in available iodine content), 0.5-1;
Solubilizing agent, 5-20;
Cosolvent, 1-10
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Surplus is purified water.
Described disinfectant solution, described guanidine class disinfectant is chlorhexidine acetate, chlorhexidine gluconate and poly hexamethylene biguanide.
Described disinfectant solution, stating chelated iodine is povidone iodine and polyalcohol ether iodine.
Described disinfectant solution, described solubilizing agent is polyglycol distearate, polyoxyethylene castor oil and polyoxyethylene hydrogenated Oleum Ricini.
Described disinfectant solution, described cosolvent is to be selected from one or more of ethanol, normal propyl alcohol, isopropyl alcohol, ethylene glycol or propylene glycol kind.
Described disinfectant solution, described skin protectant is one or more that are selected from glycerol, Polyethylene Glycol, vitamin E or D-panthenol.
Described arbitrary disinfectant solution preparation method, is characterized in that, by described content and component, cosolvent and cosolvent is joined in partial purification water, and heated and stirred is dissolved; Add successively chelated iodine, skin protectant, citric acid, stirring and dissolving; Add guanidine class disinfectant, mixing and stirring, adds after purified water to 100%, stirs again, and obtains described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
The unique formula of disinfectant solution of the present invention and preparation method, guanidine class disinfectant, chelated iodine, solubilizing agent, cosolvent are combined to use, composition compound disinfectant, make its each component produce synergism, expand antimicrobial spectrum, prevent the generation of Resistant strain, there is low irritant, quick-acting, long-acting, the feature that can indicate sterilising zone simultaneously.Solubilizing agent has solubilization to the molecular link compound of the guanidine class disinfectant generating in disinfectant solution and iodine generation, is also conducive to the cleaning after disinfectant solution is used.Citric acid maintains the faintly acid of disinfectant, and wherein containing the characteristic of minim organic solvent, alleviates the zest of disinfectant to skin, improves the use comfort of disinfectant.
The specific embodiment
In conjunction with instantiation, further illustrate the present invention below:
A kind of compound recipe guanidine class chelated iodine skin mucosa disinfectant solution, it comprises the component of following each percetage by weight:
Guanidine class, 0.1-0.6;
Chelated iodine (in available iodine content), 0.5-1;
Solubilizing agent, 5-20;
Cosolvent, 1-10
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Surplus is purified water.
Described disinfectant solution, described guanidine class disinfectant is chlorhexidine acetate, chlorhexidine gluconate and poly hexamethylene biguanide.
Described disinfectant solution, stating chelated iodine is povidone iodine and polyalcohol ether iodine.
Described disinfectant solution, described solubilizing agent is that solubilizing agent is polyglycol distearate, polyoxyethylene castor oil and polyoxyethylene hydrogenated Oleum Ricini.
Described disinfectant solution, described cosolvent is to be selected from one or more of ethanol, normal propyl alcohol, isopropyl alcohol, ethylene glycol or propylene glycol kind.
Described disinfectant solution, described skin protectant is one or more that are selected from glycerol, Polyethylene Glycol, vitamin E or D-panthenol.
Described arbitrary disinfectant solution preparation method, is characterized in that, by described content and component, cosolvent and cosolvent is joined in partial purification water, and heated and stirred is dissolved; Add successively chelated iodine, skin protectant, citric acid, stirring and dissolving; Add guanidine class disinfectant, mixing and stirring, adds after purified water to 100%, stirs again, and obtains described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
Compound recipe guanidine class chelated iodine skin mucosa disinfectant solution of the present invention detects its killing action to microorganism by version < < disinfection technology standard > > relevant regulations in 2002,0.5min is to colibacillary logarithm value >=5.00 of on average killing, 0.5min on average kills logarithm value >=5.00 to staphylococcus aureus, 0.5min on average kills logarithm value >=5.00 to Candida albicans, and 0.5min on average kills logarithm value >=5.00 to Pseudomonas aeruginosa.Its product stability and safety have all obtained sufficient checking.
Embodiment 1
100 grams of castor oil polyoxyethylene ethers and 20g ethanol are joined in 400 grams of purified water, and heated and stirred is to being uniformly dissolved; 100 grams, 10% povidone iodine powder is joined in above-mentioned solution, and stirring and dissolving is even; Add successively 1 gram of 5 grams of D-panthenol, citric acid in above-mentioned solution, be uniformly mixed; Add again 5 grams of chlorhexidine gluconates in above-mentioned solution, be uniformly mixed; Add again purified water to 1000 gram, stir, obtain described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
Embodiment 2
200 grams of castor oil polyoxyethylene ethers and 30g propylene glycol are joined in 400 grams of purified water, and heated and stirred is to being uniformly dissolved; 300 grams of polyalcohol ether iodine containing 10 grams of available iodines are joined in above-mentioned solution, and stirring and dissolving is even; Add successively 0.5 gram of 30 grams of glycerol, citric acid in above-mentioned solution, be uniformly mixed; Add again 5 grams of chlorhexidine acetates in above-mentioned solution, be uniformly mixed; Add again purified water to 1000 gram, stir, obtain described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
Embodiment 3
100 grams of polyglycol distearate and 10g ethanol are joined in 500 grams of water, and heated and stirred is to being uniformly dissolved; 200 grams, 10% povidone iodine powder is joined in above-mentioned solution, and stirring and dissolving is even; Add successively 1 gram of 10 grams of D-panthenol, citric acid in above-mentioned solution, be uniformly mixed; Add again 5 grams of chlorhexidine gluconates in above-mentioned solution, be uniformly mixed; Add again purified water to 1000 gram, stir, obtain described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
Embodiment 4
200 grams of polyglycol distearate and 10g propylene glycol are joined in 500 grams of water, and heated and stirred is to being uniformly dissolved; 300 grams of polyalcohol ether iodine containing 5 grams of available iodines are joined in above-mentioned solution, and stirring and dissolving is even; Add successively 0.5 gram of 20 grams of glycerol, citric acid in above-mentioned solution, be uniformly mixed; Add again 10 grams of poly hexamethylene biguanides in above-mentioned solution, be uniformly mixed; Add again purified water to 1000 gram, stir, obtain described compound recipe guanidine class chelated iodine skin mucosa disinfectant solution.
As the compound recipe guanidine class chelated iodine skin mucosa disinfectant solution stable in properties that above-mentioned example makes, bactericidal effect is good, low to skin, mucosa, wound, wound surface zest, and have rapid-action, the feature that the persistent period is of a specified duration, and can indicate sterilising zone, clinical easy to use, the scope of application is more extensive.
Claims (7)
1. a compound recipe guanidine class chelated iodine skin mucosa disinfectant solution, it comprises the component of following each percetage by weight:
Guanidine class, 0.1-0.6;
Chelated iodine (in available iodine content), 0.5-1;
Solubilizing agent, 5-20;
Cosolvent, 1-10
Skin protectant, 0.5-3;
Citric acid, 0.05-0.2;
Surplus is purified water.
2. disinfectant solution according to claim 1, is characterized in that, described guanidine class disinfectant is chlorhexidine acetate, chlorhexidine gluconate and poly hexamethylene biguanide.
3. disinfectant solution according to claim 1, is characterized in that, described chelated iodine is povidone iodine and polyalcohol ether iodine.
4. disinfectant solution according to claim 1, is characterized in that, described solubilizing agent is that solubilizing agent is polyglycol distearate, polyoxyethylene castor oil and polyoxyethylene hydrogenated Oleum Ricini.
5. disinfectant solution according to claim 1, is characterized in that, described cosolvent is one or more that are selected from ethanol, normal propyl alcohol, isopropyl alcohol, ethylene glycol or propylene glycol.
6. disinfectant solution according to claim 1, is characterized in that described skin protectant is one or more that are selected from glycerol, Polyethylene Glycol, vitamin E or D-panthenol.
7. according to the arbitrary disinfectant solution preparation method described in claim 1 to 6, it is characterized in that, by described content and component, cosolvent and cosolvent are joined in partial purification water, heated and stirred is dissolved; Add successively chelated iodine, skin protectant, citric acid, stirring and dissolving; Add guanidine class disinfectant, mixing and stirring, adds after purified water to 100%, stirs again, and obtains described compound recipe guanidine class iodine complex disinfection solution.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324047A (en) * | 2014-09-22 | 2015-02-04 | 天津大学 | New complex medical iodine disinfectant and preparation method thereof |
| CN104523748A (en) * | 2015-01-05 | 2015-04-22 | 四川悦康源通药业有限公司 | Compound iodine disinfectant and preparation method and application thereof |
| CN104622716A (en) * | 2015-02-27 | 2015-05-20 | 李航 | Medical nursing wet tissue which is non-alcoholic, long-acting, antibacterial and capable of removing dirt and disinfectant |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN108992462A (en) * | 2018-09-21 | 2018-12-14 | 四川悦康源通药业有限公司 | A kind of compound povidone iodine composition and preparation method thereof |
| CN109832293A (en) * | 2017-11-29 | 2019-06-04 | 江苏双盛医疗器械有限公司 | A kind of medical bactericide |
| CN109832298A (en) * | 2017-11-29 | 2019-06-04 | 江苏双盛医疗器械有限公司 | A kind of medical sterilization formulation |
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| CN101310726A (en) * | 2007-05-22 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing polyhexamethylguanidine iodine disinfectant and preparation method thereof |
| CN101461371A (en) * | 2007-12-18 | 2009-06-24 | 张洪涛 | Composite iodine carbamidine disinfecting liquid |
| CN101926819A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof |
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2013
- 2013-12-19 CN CN201310697958.6A patent/CN103735568A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101310726A (en) * | 2007-05-22 | 2008-11-26 | 上海利康消毒高科技有限公司 | Alcohol-containing polyhexamethylguanidine iodine disinfectant and preparation method thereof |
| CN101461371A (en) * | 2007-12-18 | 2009-06-24 | 张洪涛 | Composite iodine carbamidine disinfecting liquid |
| CN101926819A (en) * | 2009-06-23 | 2010-12-29 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine complexing iodine disinfector and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324047A (en) * | 2014-09-22 | 2015-02-04 | 天津大学 | New complex medical iodine disinfectant and preparation method thereof |
| CN104523748A (en) * | 2015-01-05 | 2015-04-22 | 四川悦康源通药业有限公司 | Compound iodine disinfectant and preparation method and application thereof |
| CN104622716A (en) * | 2015-02-27 | 2015-05-20 | 李航 | Medical nursing wet tissue which is non-alcoholic, long-acting, antibacterial and capable of removing dirt and disinfectant |
| CN109832293A (en) * | 2017-11-29 | 2019-06-04 | 江苏双盛医疗器械有限公司 | A kind of medical bactericide |
| CN109832298A (en) * | 2017-11-29 | 2019-06-04 | 江苏双盛医疗器械有限公司 | A kind of medical sterilization formulation |
| CN108904527A (en) * | 2018-09-07 | 2018-11-30 | 郑州吉尔康消毒制品有限公司 | Composite skin sterilizing liquid composite and preparation method thereof |
| CN108992462A (en) * | 2018-09-21 | 2018-12-14 | 四川悦康源通药业有限公司 | A kind of compound povidone iodine composition and preparation method thereof |
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Application publication date: 20140423 |