CN111166841A - Skin disinfection combined medicament and preparation method and use method thereof - Google Patents

Skin disinfection combined medicament and preparation method and use method thereof Download PDF

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Publication number
CN111166841A
CN111166841A CN202010011208.9A CN202010011208A CN111166841A CN 111166841 A CN111166841 A CN 111166841A CN 202010011208 A CN202010011208 A CN 202010011208A CN 111166841 A CN111166841 A CN 111166841A
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skin
solution
disinfection
antibacterial
disinfectant
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CN111166841B (en
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李忠良
何成霞
汪蟠
陈福海
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Chengdu Rosun Disinfection Pharmaceutical Co ltd
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Chengdu Rosun Disinfection Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01N59/02—Sulfur; Selenium; Tellurium; Compounds thereof
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Abstract

The invention discloses a skin disinfection combined medicament, a preparation method and a use method thereof, and belongs to the technical field of disinfection. It comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and/or iodophor disinfection solution. The invention takes the skin antibacterial liquid as the main part and takes the skin disinfectant and the iodophor disinfectant as the auxiliary parts to prevent and treat tinea pedis and onychomycosis; the potassium hydrogen peroxymonosulfate sterilizing powder is used for killing residual pathogenic microorganisms on shoes, socks and basins and preventing disease recurrence.

Description

Skin disinfection combined medicament and preparation method and use method thereof
Technical Field
The invention relates to the technical field of disinfection, in particular to a skin disinfection combined medicament and a preparation method and a use method thereof.
Background
Human feet are wrapped by shoes and socks, so that the secretion is much, bacteria are easy to grow on the feet, and the bacteria cause foot diseases (tinea pedis and onychomycosis) and harm the human health. Correctly disinfect and protect, is beneficial to eradicating beriberi and maintaining foot health. At present, the medicaments for treating tinea pedis and onychomycosis mainly have the following defects: (1) single efficacy, failure of comprehensive protection and easy relapse. (2) Strong irritation, and adverse reactions such as skin crack and desquamation.
Disclosure of Invention
The invention aims to provide a skin disinfection combined medicament, a preparation method and a use method thereof, and aims to solve the problems of single effect and strong irritation of the existing medicament for treating tinea pedis and onychomycosis.
The technical scheme for solving the technical problems is as follows:
a skin sanitizing combination comprising the following: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and/or iodophor disinfection solution.
The invention uses potassium hydrogen peroxymonosulfate disinfection powder to disinfect shoes, socks and foot basins, uses skin disinfection solution to disinfect foot skin and nails, uses skin antibacterial solution to carry out antibacterial treatment on the surface and shallow layers of the foot skin and the nails, and uses iodophor to treat onychomycosis and skin wounds. The invention takes the skin antibacterial liquid as the main component and takes other three medicaments as the auxiliary components, thereby preventing and treating tinea pedis and onychomycosis, having comprehensive efficacy, more thorough protection, high cure rate and relapse prevention.
Further, in a preferred embodiment of the present invention, the skin disinfection solution includes: 0.4-0.6% of chlorhexidine acetate, 0.4-0.6% of traditional Chinese medicine extracting solution, 0-0.1% of salicylic acid, 0-0.1% of benzoic acid, 0.05-0.2% of thymol, 0.4-0.6% of borneol, 0.4-0.7% of menthol, 46-50% of ethanol, 1-5% of propylene glycol, 0.2-0.22% of eucalyptus oil, 0.2-0.22% of wintergreen oil, 0.05-0.06% of oil-soluble azone, 0.3-0.4% of hydrogenated castor oil polyoxyethylene ether, 0.1-0.2% of penetrating agent JFC and the balance of distilled water.
The skin disinfectant disclosed by the invention contains chlorhexidine acetate, ethanol, a traditional Chinese medicine extracting solution, salicylic acid and benzoic acid as main sterilization components, and has the sterilization and disinfection effects. In addition, thymol, eucalyptus oil, wintergreen oil, borneol and menthol are added to achieve the effects of relieving itching and removing peculiar smell, and meanwhile, the disinfectant has a certain bactericidal effect and can assist the main bactericidal components in synergism to improve the bactericidal effect. In addition, the added ethanol can also shorten the drying time of the disinfectant, and the use is more convenient.
In order to improve the permeability of the skin disinfectant, oil-soluble azone is added as a skin penetrating agent, which is beneficial to the effective ingredients of the medicine to permeate into the superficial layer of the skin. In addition, the added propylene glycol, hydrogenated castor oil polyoxyethylene ether and penetrating agent JFC can increase the solubility of oil-soluble ingredients such as borneol, menthol and the like in water, are beneficial to preparing products into uniform liquid, and have a certain moisturizing effect and prevent skin chapping.
Further, in a preferred embodiment of the present invention, the method for preparing the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 50-55 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 10-15min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, salicylic acid, benzoic acid and ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first solution into the second solution, and stirring for 5-10 min;
(4) cooling to room temperature, supplementing water to 100%, stirring for 5-10min, and filtering to obtain the skin disinfectant.
Further, in a preferred embodiment of the present invention, the skin antibacterial liquid includes: the skin antibacterial liquid comprises: 0.3-0.5% of chlorhexidine acetate, 0.9-1.1% of traditional Chinese medicine extracting solution, 0.05-0.14% of salicylic acid, 0.05-0.14% of benzoic acid, 6-8% of acetic acid, 0.05-0.5% of thymol, 0.05-0.08% of borneol, 0.02-0.05% of menthol, 2.2-2.5% of ethanol, 0.5-1% of propylene glycol, 0.01-0.1% of eucalyptus oil, 0.01-0.1% of wintergreen oil, 0.05-0.1% of oil-soluble azone, 1.1-1.5% of hydrogenated castor oil polyoxyethylene ether, 0-1% of malic acid, 0-1% of citric acid, 0-0.01% of cason and the balance of distilled water.
The chlorhexidine acetate, the traditional Chinese medicine extracting solution, the salicylic acid, the benzoic acid and the acetic acid in the skin antibacterial liquid are used as main antibacterial components, have the effects of sterilization and bacteriostasis, and particularly have good inhibitory action on fungi on feet. Wherein, the chlorhexidine acetate is used as a chemical antibacterial agent and has stronger antibacterial effect. Acetic acid is one of antibacterial components, and has strong fungus killing effect; it can penetrate into superficial layer of skin, and can soften diseased nails infected with tinea unguium, and can be used in combination with iodophor for treating tinea unguium (onychomycosis).
In addition, the added acetic acid, salicylic acid, malic acid and citric acid can soften hard skin, soften diseased nails infected with onychomycosis, and facilitate the function of the bactericidal component. The addition of malic acid and citric acid can reduce the consumption of acetic acid, reduce the pungent odor of the product, enhance the acidity of the medicinal liquid, and enhance the antibacterial effect.
In addition, thymol, eucalyptus oil, wintergreen oil, borneol and menthol are added to relieve itching, mask odor and generate a cooling effect, and have a certain antibacterial effect to assist and synergize main antibacterial ingredients to improve the antibacterial effect.
Finally, oil-soluble azone is added as a skin penetrating agent, which is beneficial to the effective ingredients of the medicine to permeate into the superficial layers of the skin. The propylene glycol, the ethanol and the hydrogenated castor oil polyoxyethylene ether are also added to increase the solubility of oil-soluble components such as borneol, menthol and the like in water, so that the product can be prepared into uniform liquid, and the propylene glycol and the hydrogenated castor oil polyoxyethylene ether also have certain moisturizing effect and can prevent skin from chapping. The skin antibacterial liquid reduces irritation and avoids skin cracking and desquamation under the condition of ensuring the curative effect.
Further, in a preferred embodiment of the present invention, the method for preparing the skin antibacterial liquid comprises the following steps:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 50-55 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 15-20min at a constant temperature to obtain an antibacterial first solution;
(3) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to obtain an antibacterial second solution;
(4) mixing malic acid, citric acid and kasong, adding into distilled water with a weight of 3-5 times of the total weight, and stirring to dissolve completely to obtain an antibacterial third solution;
(5) adding the first antibacterial solution into the second antibacterial solution, stirring for 5-10min, adding the third antibacterial solution, and stirring for 5-10 min; supplementing water to 100%, stirring for 5-10min, cooling to room temperature, and filtering to obtain the skin antibacterial liquid.
Further, in a preferred embodiment of the present invention, the above traditional Chinese medicine extract is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, toosendan fruit, sophora flavescens, cortex pseudolaricis, cortex dictamni and radix stemonae, and the mass ratio of the traditional Chinese medicine extract to the extract is 1: 6-10: 1-5: 1-5: 6-10: 1-5: 1-5: 1-5.
The traditional Chinese medicine extracting solution has the effects of killing bacteria and fungi and preventing pruritus. Specifically, berberine extracted from coptis chinensis and phellodendron bark belongs to a quaternary ammonium alkaloid, is a main antibacterial active ingredient of coptis chinensis, has a wide antibacterial spectrum, and has an antibacterial effect on various gram positive and negative bacteria in vitro, wherein the berberine can inhibit hemolytic streptococcus, staphylococcus aureus and vibrio cholerae. Meningococcus, shigella dysenteriae, typhoid bacillus, diphtheria bacillus and the like have strong inhibiting effect, and can inhibit bacteria at low concentration and kill bacteria at high concentration. The radix Sophorae Flavescentis extract contains matrine, sophocarpine, oxysophocarpine, sophoridine, etc. as main ingredients, and has the highest content of matrine and oxysophocarpine. Has effects of clearing heat, promoting urination, killing parasite, eliminating dampness, resisting virus, tumor and allergy. The osthole extracted from fructus Cnidii contains pinene, camphene, isoborneol isovalerate, isoborneol, methoxy parsley phenol, osthole, cnidium lactone, and broad-spectrum antibacterial effect, and has spasmolytic, blood pressure lowering, arrhythmia resisting, immunity enhancing, and antibacterial effects. Toosendanin extracted from fructus Toosendan has effects of dispersing stagnated liver qi, clearing heat, activating qi-flowing, relieving pain, and killing parasite. Stemonine extracted from radix Stemonae has inhibitory effect on most pathogenic bacteria and dermatophytes, and also has tranquilizing and analgesic effects. The pseudolaric acid extracted from cortex pseudolaricis has certain antibacterial effect on 10 common pathogenic fungi, especially on Trichophyton schoenleinii, Epidermophyton floccosum, Microsporum ferrugineum, Microsporum gypseum and Candida albicans. The dictamnine extracted from cortex Dictamni has therapeutic effects on toxic heat wind, aversion to wind, scabies, tinea, eyebrows, dermatosis, and hyperpyrexia. Further, in a preferred embodiment of the present invention, the method for preparing the Chinese medicine extract solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 3-5 times of pure water for 2-3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 24 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 5-10 times of 70% ethanol for 48 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates obtained in the steps (1) and (2), and adjusting the density to 0.85 with 95% ethanol to obtain the Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 50-60% of potassium hydrogen peroxymonosulfate composite salt, 1.2-1.5% of citric acid, 1-11% of malic acid, 3-5% of sulfamic acid, 26-29% of sodium hexametaphosphate, 4-5% of sodium dodecyl benzene sulfonate and 1.3-1.8% of sodium chloride for 15-20min, sampling, inspecting, discharging, subpackaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.45-0.55%.
The use method of the skin disinfection combined medicament comprises the following steps:
(1) for beriberi (tinea pedis), the skin of the foot has no cracks and no wound:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of about 4g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) for onychomycosis (onychomycosis), the skin of foot has no crack or wound;
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the foot antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off the soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in potassium monopersulfate solution of concentration 4g/L for 20min, washing and drying;
before going out, the feet and socks are sprayed with skin disinfectant once.
Further, in a preferred embodiment of the present invention, in the method for using the skin disinfection combination drug, for a skin lesion: the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Aiming at partial beriberi patients, the skin of feet has cracks, water ditches or wounds, the disinfectant and the antibacterial liquid are directly used, and the irritation is strong, so that the wound healing is not facilitated; iodophor has strong bactericidal power and very low irritation to damaged skin. For the patients with incomplete foot skin, the wound should be healed first, and then the beriberi should be treated.
The invention has the following beneficial effects:
the skin disinfection combination medicament can disinfect and disinfect the skin and the wound of the foot of a human body, and meanwhile, the contact objects of shoes, socks, foot basins and the like with the foot of the human body are disinfected to block the transmission path of pathogenic bacteria, so that the skin disinfection combination medicament has comprehensive effects, can comprehensively protect the skin of the foot, and can inhibit relapse in many aspects. The skin disinfection combination medicament has high safety, no toxicity, no irritation to skin, no harm to environment and suitability for beriberi caused by bacteria, fungi and mixed infection.
Detailed Description
The principles and features of this invention are described below in conjunction with embodiments, which are included to explain the invention and not to limit the scope of the invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
Example 1:
the skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and iodophor disinfection solution.
Wherein, the skin disinfection solution includes: 0.4 percent of chlorhexidine acetate, 0.4 percent of traditional Chinese medicine extracting solution, 0 percent of salicylic acid, 0 percent of benzoic acid, 0.05 percent of thymol, 0.4 percent of borneol, 0.4 percent of menthol, 46 percent of ethanol, 1 percent of propylene glycol, 0.2 percent of eucalyptus oil, 0.2 percent of wintergreen oil, 0.05 percent of oil-soluble azone, 0.3 percent of hydrogenated castor oil polyoxyethylene ether, 0.1 percent of penetrating agent JFC and the balance of distilled water.
The preparation method of the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 50 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 10min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, salicylic acid, benzoic acid and ethanol are dissolved and transparent to obtain a second solution;
(3) adding the first solution into the second solution, and stirring for 5 min;
(4) cooling to room temperature, adding water to 100%, stirring for 5min, and filtering to obtain skin disinfectant.
Wherein, skin antibacterial liquid includes: by weight and volume ratio, chlorhexidine acetate 0.3%, traditional Chinese medicine extract 0.9%, salicylic acid 0.05%, benzoic acid 0.05%, acetic acid 6%, thymol 0.05%, borneol 0.05%, menthol 0.02%, ethanol 2.2%, propylene glycol 0.5%, eucalyptus oil 0.01%, wintergreen oil 0.01%, oil-soluble azone 0.05% and hydrogenated castor oil polyoxyethylene ether 1.1%, and the balance of distilled water.
The preparation method of the skin antibacterial liquid comprises the following steps:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 50 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 15min at a constant temperature to obtain an antibacterial first solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to obtain an antibacterial second solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water with the weight of 3 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain an antibacterial third solution;
(4) adding the antibacterial first solution into the antibacterial second solution, stirring for 5min, adding the antibacterial third solution, and stirring for 5 min; supplementing water to full dose, stirring for 5min, cooling to room temperature, and filtering to obtain skin antibacterial liquid.
Wherein, the traditional Chinese medicine extracting solution is as follows: is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, szechwan chinaberry fruit, radix sophorae flavescentis, golden larch bark, cortex dictamni and radix stemonae in a mass ratio of 1: 6: 1: 1: 6: 1: 1: 1.
the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 3 times of pure water for 2 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 20 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 5 times of 70% ethanol for 45 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates of step (1) and step (2), and adjusting the density to 0.85 with 95% ethanol to obtain Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 50% of potassium hydrogen peroxymonosulfate composite salt, 1.2% of citric acid, 1% of malic acid, 3% of sulfamic acid, 26% of sodium hexametaphosphate, 4% of sodium dodecyl benzene sulfonate and 1.3% of sodium chloride for 15min, sampling, inspecting, discharging, subpackaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.45%.
The method for using the skin disinfection combination medicament of the embodiment comprises the following steps:
(1) beriberi (tinea pedis), flawless and non-wound foot skin:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of 3-5g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) onychomycosis (onychomycosis), no cracks and wounds on the skin of the foot.
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in 3-5g/L potassium monopersulfate solution for 20min, washing and drying;
before going out, the feet and the socks are sprayed with the skin disinfectant, and the inner surfaces of the shoes are sprayed once;
(3) those with damaged skin:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Example 2:
the skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and iodophor disinfection solution.
Wherein, the skin disinfection solution includes: 0.45 percent of chlorhexidine acetate, 0.45 percent of traditional Chinese medicine extracting solution, 0.01 percent of salicylic acid, 0.01 percent of benzoic acid, 0.1 percent of thymol, 0.45 percent of borneol, 0.5 percent of menthol, 47 percent of ethanol, 2 percent of propylene glycol, 0.21 percent of eucalyptus oil, 0.21 percent of wintergreen oil, 0.055 percent of oil-soluble azone, 0.35 percent of hydrogenated castor oil polyoxyethylene ether, 0.15 percent of penetrating agent JFC and the balance of distilled water.
The preparation method of the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 52 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 12min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, salicylic acid, benzoic acid and ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first sterilized solution into the second sterilized solution, and stirring for 7 min;
(4) cooling to room temperature, adding water to full volume, stirring for 7min, and filtering to obtain skin disinfectant.
Wherein, skin antibacterial liquid includes: 0.35 percent of chlorhexidine acetate, 1.0 percent of traditional Chinese medicine extracting solution, 0.07 percent of salicylic acid, 0.07 percent of benzoic acid, 6.5 percent of acetic acid, 0.1 percent of thymol, 0.06 percent of borneol, 0.03 percent of menthol, 2.3 percent of ethanol, 0.6 percent of propylene glycol, 0.03 percent of eucalyptus oil, 0.03 percent of wintergreen oil, 0.07 percent of oil-soluble azone, 1.2 percent of hydrogenated castor oil polyoxyethylene ether and 0.2 percent of malic acid, and the balance of distilled water.
The preparation method of the skin antibacterial liquid comprises the following steps:
mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 52 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 17min at a constant temperature to obtain an antibacterial first solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to obtain an antibacterial second solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water of which the weight is 4 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain an antibacterial third solution;
(4) adding the antibacterial first solution into the antibacterial second solution, stirring for 7min, adding the antibacterial third solution, and stirring for 7 min; supplementing water to full dose, stirring for 7min, cooling to room temperature, and filtering to obtain the skin antibacterial liquid.
Wherein, the traditional Chinese medicine extracting solution is as follows: is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, szechwan chinaberry fruit, radix sophorae flavescentis, golden larch bark, cortex dictamni and radix stemonae in a mass ratio of 1: 7: 2: 2: 7: 2: 2: 3.
the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 4 times of pure water for 3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 24 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 7 times of 70% ethanol for 48 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates obtained in the steps (1) and (2), and adjusting the density to 0.85 with 95% ethanol to obtain the Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 52% of potassium hydrogen peroxymonosulfate composite salt, 1.3% of citric acid, 3% of malic acid, 3.5% of sulfamic acid, 27% of sodium hexametaphosphate, 4.3% of sodium dodecyl benzene sulfonate and 1.4% of sodium chloride for 17min, sampling, inspecting, discharging, subpackaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.5%.
The method for using the skin disinfection combination medicament of the embodiment comprises the following steps:
(1) beriberi (tinea pedis), flawless and non-wound foot skin:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of 3-5g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) onychomycosis (onychomycosis), no cracks and wounds on the skin of the foot.
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in 3-5g/L potassium monopersulfate solution for 20min, washing and drying;
before going out, the feet and the socks are sprayed with the skin disinfectant, and the inner surfaces of the shoes are sprayed once;
(3) those with damaged skin:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Example 3:
the skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and iodophor disinfection solution.
Wherein, the skin disinfection solution includes: by weight and volume ratio, chlorhexidine acetate 0.5%, traditional Chinese medicine extract 0.5%, salicylic acid 0.05%, benzoic acid 0.05%, thymol 0.15%, borneol 0.5%, menthol 0.6%, ethanol 48%, propylene glycol 3%, eucalyptus oil 0.21%, wintergreen oil 0.21%, oil-soluble azone 0.55%, hydrogenated castor oil polyoxyethylene ether 0.35%, penetrant JFC 0.15%, and the balance of distilled water.
The preparation method of the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 50-55 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 13min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, salicylic acid, benzoic acid and ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first sterilized solution into the second sterilized solution, and stirring for 7 min;
(4) cooling to room temperature, adding water to 100%, stirring for 7min, and filtering to obtain skin disinfectant.
Wherein, skin antibacterial liquid includes: by weight and volume ratio, chlorhexidine acetate 0.4%, traditional Chinese medicine extract 1.0%, salicylic acid 0.11%, benzoic acid 0.11%, acetic acid 7%, thymol 0.2%, borneol 0.06%, menthol 0.04%, ethanol 2.3%, propylene glycol 0.7%, eucalyptus oil 0.05%, wintergreen oil 0.05%, oil-soluble azone 0.07%, hydrogenated castor oil polyoxyethylene ether 1.3%, malic acid 0.7%, citric acid 0.05%, and karson 0.01%, and the balance of distilled water.
The preparation method of the skin antibacterial liquid comprises the following steps:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 53 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 17min at a constant temperature to obtain an antibacterial first solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to obtain an antibacterial second solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water of which the weight is 4 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain an antibacterial third solution;
(4) adding the first antibacterial solution into the second antibacterial solution, stirring for 7min, adding the third antibacterial solution, and stirring for 5-10 min; supplementing water to full dose, stirring for 7min, cooling to room temperature, and filtering to obtain the skin antibacterial liquid.
Wherein, the traditional Chinese medicine extracting solution is as follows: is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, szechwan chinaberry fruit, radix sophorae flavescentis, golden larch bark, cortex dictamni and radix stemonae in a mass ratio of 1: 9: 3: 3: 9: 3: 3: 3.
the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 4 times of pure water for 3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 24 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 7 times of 70% ethanol for 48 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates of step (1) and step (2), and adjusting the density to 0.85 with 95% ethanol to obtain Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 55% of potassium hydrogen peroxymonosulfate composite salt, 1.35% of citric acid, 7% of malic acid, 4% of sulfamic acid, 28% of sodium hexametaphosphate, 4.5% of sodium dodecyl benzene sulfonate and 1.7% of sodium chloride for 18min, sampling, inspecting, discharging, subpackaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.5%.
The method for using the skin disinfection combination medicament of the embodiment comprises the following steps:
(1) beriberi (tinea pedis), flawless and non-wound foot skin:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of 3-5g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) onychomycosis (onychomycosis), no cracks and wounds on the skin of the foot.
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in 3-5g/L potassium monopersulfate solution for 20min, washing and drying;
before going out, the feet and the socks are sprayed with the skin disinfectant, and the inner surfaces of the shoes are sprayed once;
(3) those with damaged skin:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Example 4:
the skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and iodophor disinfection solution.
Wherein, the skin disinfection solution includes: by weight and volume ratio, chlorhexidine acetate 0.55%, traditional Chinese medicine extract 0.55%, salicylic acid 0.07%, benzoic acid 0.07%, thymol 0.17%, borneol 0.57%, menthol 0.65%, ethanol 48%, propylene glycol 4%, eucalyptus oil 0.21%, wintergreen oil 0.21%, oil-soluble azone 0.055%, hydrogenated castor oil polyoxyethylene ether 0.35%, penetrating agent JFC 0.17%, and the balance of distilled water.
The preparation method of the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 53 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 13min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, salicylic acid, benzoic acid and ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first sterilized solution into the second sterilized solution, and stirring for 9 min;
(4) cooling to room temperature, adding water to 100%, stirring for 9min, and filtering to obtain skin disinfectant.
Wherein, skin antibacterial liquid includes: 0.45 percent of chlorhexidine acetate, 1.0 percent of traditional Chinese medicine extracting solution, 0.12 percent of salicylic acid, 0.12 percent of benzoic acid, 7.5 percent of acetic acid, 0.4 percent of thymol, 0.07 percent of borneol, 0.04 percent of menthol, 2.4 percent of ethanol, 0.9 percent of propylene glycol, 0.08 percent of eucalyptus oil, 0.08 percent of wintergreen oil, 0.08 percent of oil-soluble azone, 1.4 percent of hydrogenated castor oil polyoxyethylene ether, 0.8 percent of malic acid, 0.8 percent of citric acid and 0.08 percent of cason, and the balance of distilled water.
The preparation method of the skin antibacterial liquid comprises the following steps:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 53 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 19min at a constant temperature to obtain an antibacterial first solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to obtain an antibacterial second solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water of which the weight is 4 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain an antibacterial third solution;
(4) adding the antibacterial first solution into the antibacterial second solution, stirring for 9min, adding the antibacterial third solution, and stirring for 9 min; supplementing water to full dose, stirring for 9min, cooling to room temperature, and filtering to obtain the skin antibacterial liquid.
Wherein the traditional Chinese medicine extracting solution is as follows: is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, szechwan chinaberry fruit, radix sophorae flavescentis, golden larch bark, cortex dictamni and radix stemonae in a mass ratio of 1: 9: 3: 3: 9: 3: 3: 3.
the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 4 times of pure water for 2-3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 24 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 9 times of 70% ethanol for 48 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates obtained in the steps (1) and (2), and adjusting the density to 0.85 with 95% ethanol to obtain the Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 67% of potassium hydrogen peroxymonosulfate composite salt, 1.4% of citric acid, 9% of malic acid, 4.5% of sulfamic acid, 28% of sodium hexametaphosphate, 4.7% of sodium dodecyl benzene sulfonate and 1.6% of sodium chloride for 18min, sampling, inspecting, qualifying, discharging, subpackaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.5%.
The method for using the skin disinfection combination medicament of the embodiment comprises the following steps:
(1) beriberi (tinea pedis), flawless and non-wound foot skin:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of about 4g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) onychomycosis (onychomycosis), no cracks and wounds on the skin of the foot.
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in potassium monopersulfate solution of concentration 4g/L for 20min, washing and drying;
before going out, the feet and the socks are sprayed with the skin disinfectant, and the inner surfaces of the shoes are sprayed once;
(3) those with damaged skin:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Example 5:
the skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and iodophor disinfection solution.
Wherein, the skin disinfection solution includes: by weight and volume ratio, chlorhexidine acetate 0.6%, traditional Chinese medicine extract 0.6%, salicylic acid 0.1%, benzoic acid 0.1%, thymol 0.2%, borneol 0.6%, menthol 0.7%, ethanol 50%, propylene glycol 5%, eucalyptus oil 0.22%, wintergreen oil 0.22%, oil-soluble azone 0.06%, hydrogenated castor oil polyoxyethylene ether 0.4%, penetrant JFC 0.2%, and the balance of distilled water.
The preparation method of the skin disinfection solution comprises the following steps:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and a penetrating agent JFC, heating to 55 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 15min at the constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, the salicylic acid, the benzoic acid and the ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first disinfectant solution into the second disinfectant solution, and stirring for 10 min;
(4) cooling to room temperature, adding water to 100%, stirring for 10min, and filtering to obtain skin disinfectant.
Wherein, skin antibacterial liquid includes: by weight and volume ratio, chlorhexidine acetate 0.5%, traditional Chinese medicine extract 1.1%, salicylic acid 0.14%, benzoic acid 0.14%, acetic acid 8%, thymol 0.5%, borneol 0.08%, menthol 0.05%, ethanol 2.5%, propylene glycol 1%, eucalyptus oil 0.1%, wintergreen oil 0.1%, oil-soluble azone 0.1%, hydrogenated castor oil polyoxyethylene ether 1.5%, malic acid 1%, citric acid 1%, cason 0.01%, and the balance of distilled water.
The preparation method of the skin antibacterial liquid comprises the following steps:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether, heating to 55 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 20min at the constant temperature to obtain a first antibacterial solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to be transparent to obtain a second antibacterial solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water of which the weight is 5 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain a third antibacterial solution;
(4) adding the first antibacterial solution into the second antibacterial solution, stirring for 10min, adding the third antibacterial solution, and stirring for 5-10 min; supplementing water to 100%, stirring for 10min, cooling to room temperature, and filtering to obtain skin antibacterial liquid.
Wherein, the traditional Chinese medicine extracting solution is as follows: is prepared by extracting coptis chinensis, phellodendron, fructus cnidii, szechwan chinaberry fruit, radix sophorae flavescentis, golden larch bark, cortex dictamni and radix stemonae in a mass ratio of 1: 10: 5: 5: 10: 5: 5: 5.
the preparation method of the traditional Chinese medicine extracting solution comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 5 times of pure water for 3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 26 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 10 times of 70% ethanol for 50 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates obtained in the steps (1) and (2), and adjusting the density to 0.85 with 95% ethanol to obtain the Chinese medicinal extractive solution.
The preparation method of the skin disinfection combination medicament comprises the following steps:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing potassium hydrogen peroxymonosulfate compound salt 60%, citric acid 5%, malic acid 11%, sulfamic acid 5%, sodium hexametaphosphate 29%, sodium dodecyl benzene sulfonate 5% and sodium chloride 1.8% for 20min, sampling, inspecting, discharging, packaging, sealing and storing; wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.55%.
The method for using the skin disinfection combination medicament of the embodiment comprises the following steps:
(1) beriberi (tinea pedis), flawless and non-wound foot skin:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of about 4g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) onychomycosis (onychomycosis), no cracks and wounds on the skin of the foot.
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in potassium monopersulfate solution of concentration 4g/L for 20min, washing and drying;
before going out, the feet and the socks are sprayed with the skin disinfectant, and the inner surfaces of the shoes are sprayed once;
(3) those with damaged skin:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
Example 6
The skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection liquid and skin antibacterial liquid.
Wherein, the compositions of the potassium hydrogen peroxymonosulfate disinfection powder, the skin disinfection solution and the skin antibacterial solution and the preparation method of the skin disinfection combination medicament are the same as the embodiment 1.
Example 7
The skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection liquid and skin antibacterial liquid.
Wherein, the compositions of the potassium hydrogen peroxymonosulfate disinfection powder, the skin disinfection solution and the skin antibacterial solution and the preparation method of the skin disinfection combination medicament are the same as the embodiment 2.
Example 8
The skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection liquid and skin antibacterial liquid.
Wherein, the compositions of the potassium hydrogen peroxymonosulfate disinfection powder, the skin disinfection solution and the skin antibacterial solution and the preparation method of the skin disinfection combination medicament are the same as the embodiment 3.
Example 9
The skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection liquid and skin antibacterial liquid.
Wherein, the compositions of the potassium hydrogen peroxymonosulfate disinfection powder, the skin disinfection solution and the skin antibacterial solution and the preparation method of the skin disinfection combination medicament are the same as the embodiment 4.
Example 10
The skin sanitizing combination medicament of this embodiment comprises: comprises the following medicaments: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection liquid and skin antibacterial liquid.
Wherein, the compositions of the potassium hydrogen peroxymonosulfate disinfection powder, the skin disinfection solution and the skin antibacterial solution and the preparation method of the skin disinfection combination medicament are the same as the embodiment 5.
Example 11
The method of using the skin sanitizing combination as described in any one of embodiments 1-5 above, comprising the steps of: for onychomycosis (onychomycosis), the skin of foot has no crack or wound;
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the foot antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in 3-5g/L potassium monopersulfate solution for 20min, washing and drying;
before going out, the feet and socks are sprayed with skin disinfectant once.
Example 12
The method of using the skin sanitizing combination as described in any one of embodiments 6-10 above, comprising the steps of: for beriberi (tinea pedis), the skin of the foot has no cracks and no wound:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of 3-5g/L for 20 minutes, and then are cleaned and dried;
④, before going out, the inner surfaces of the feet, the socks and the shoes are sprayed with the skin disinfectant for one time.
Example 13
For skin lesions: the wounds were rubbed 1-2 times daily with iodophor disinfectant and, after healing, sterilized as in example 12 or example 13.
Test examples
Firstly, sample detection
The disinfectant and antibacterial agent combination obtained in example 2 was examined according to "Disinfection technical Specification" of Ministry of health, and the results are shown in the following table:
TABLE 1 Potassium hydrogen peroxymonosulfate disinfectant powder
Figure BDA0002357220730000221
TABLE 2 skin disinfectant
Figure BDA0002357220730000231
TABLE 3 skin antiseptic solution
Figure BDA0002357220730000232
Figure BDA0002357220730000241
Second, application test
(first) test 1
1. Cases and methods
(1) Selecting an object
30 patients with tinea pedis or onychomycosis were selected, and all patients were positive by fungal microscopic examination, 20 men and 10 women, and aged 22-50 years.
(2) Grouping
The samples were randomly divided into two groups of 15 each. In the test group, 10 men and 5 women were included. The disease part: 8 cases are dorsum of foot, 5 cases are between toes, 2 cases are nails, and the disease types include: 10 cases are skin pruritus and heavy abnormal flavor, 3 cases are skin ulceration, and 2 cases are onychomycosis; in the control group, 10 men and 5 women were treated. The disease part: 7 cases are dorsum of foot, 5 cases are between toes, 3 cases are nails, and the disease types include: 10 cases are skin pruritus and heavy abnormal flavor, 2 cases are skin ulceration, and 3 cases are onychomycosis;
(3) test method
in the control group, the feet were washed with warm water every night.
② test group, using ② example 3 of ② pharmaceutical composition of ② present invention, was sterilized as follows:
A. the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of about 4g/L for 20 minutes: cleaning and drying.
The disinfection frequency is as follows: the shoes are used for sports and walking once in 3-5 days; socks once in 2-3 days; the foot bath is carried out once a day.
B. Foot infection, tinea pedis or onychomycosis, intact skin, no cracks, no wounds:
a. 200-400ml of skin antibacterial liquid is poured into the foot bath basin, feet are soaked for 10-20 minutes, and the feet are wiped dry or washed by warm water.
b. The soft diseased nails were removed with a nail clipper and coated with iodophor solution.
c. Before going out, the inner surface of the shoes is disinfected once by spraying skin disinfectant.
d. The application method is once a day.
C. Foot infection with tinea pedis or onychomycosis, skin cracks or wounds:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (2).
2. Test results
The results show that after one week of treatment, 6 cases of the experimental group are cured, 5 cases are effective, 3 cases are effective, 1 case is ineffective, the cure rate is 40%, and the total effective rate is 93.33%.
The control group showed no significant change from the pre-test group.
(II) test 2
1. Cases and methods
(1) Selecting an object
30 patients with tinea pedis were selected, and all patients were positive by microscopic examination of fungi, 20 men and 10 women, and aged 22-50 years.
(2) Grouping
The samples were randomly divided into two groups of 15 each. In the test group, 10 men and 5 women were included. The disease part: 6 cases are dorsum of foot, 6 cases are between toes, 3 cases are nails, and the disease types include: 9 cases are skin pruritus and heavy abnormal flavor, 3 cases are skin ulceration, and 3 cases are onychomycosis; in the control group, 10 men and 5 women were treated. The disease part: there are 7 cases of dorsum of foot, 6 cases of intertoe, 2 cases of nail, and the disease types include: 10 cases are skin pruritus and heavy abnormal flavor, 3 cases are skin ulceration, and 2 cases are onychomycosis;
(3) test method
in contrast group, foot powder (radix Sophorae Flavescentis, salicylic acid, benzoic acid, and boric acid) is added with warm water and soaked for 10-20 min every night.
② test group, using ② example 3 of ② pharmaceutical composition of ② present invention, was sterilized as follows:
A. the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of about 4g/L for 20 minutes: cleaning and drying.
The disinfection frequency is as follows: the shoes are used for sports and walking once in 3-5 days; socks once in 2-3 days; the foot bath is carried out once a day.
B. Foot infection, tinea pedis or onychomycosis, intact skin, no cracks, no wounds:
a. 200-400ml of skin antibacterial liquid is poured into the foot bath basin, feet are soaked for 10-20 minutes, and the feet are wiped dry or washed by warm water.
b. The soft diseased nails were removed with a nail clipper and coated with iodophor solution.
c. Before going out, the inner surface of the shoes is disinfected once by spraying skin disinfectant.
d. The application method is once a day.
C. Foot infection with tinea pedis or onychomycosis, skin cracks or wounds:
the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (2).
2. Test results
The results show that after one week of treatment, 7 cases of the experimental groups are cured, 5 cases are effective, 3 cases are effective, 1 case is ineffective, the cure rate is 46.66%, and the total effective rate is 93.33%.
In the control group, 6 cases are cured, 4 cases are obvious in effect, 4 cases are effective, 1 case is ineffective, the cure rate is 40%, and the total effective rate is 93.33%.
After one week of the test, the foot skin of the testee in the control group has the phenomena of roughness, cracks, desquamation and the like; the test group is not, which indicates that the drug in the test group has less irritation.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1. A skin sanitizing composition comprising the following agents: potassium hydrogen peroxymonosulfate disinfection powder, skin disinfection solution, skin antibacterial solution and/or iodophor disinfection solution.
2. The skin disinfectant combination according to claim 1, wherein said skin disinfectant liquid comprises: 0.4-0.6% of chlorhexidine acetate, 0.4-0.6% of traditional Chinese medicine extracting solution, 0-0.1% of salicylic acid, 0-0.1% of benzoic acid, 0.05-0.2% of thymol, 0.4-0.6% of borneol, 0.4-0.7% of menthol, 46-50% of ethanol, 1-5% of propylene glycol, 0.2-0.22% of eucalyptus oil, 0.2-0.22% of wintergreen oil, 0.05-0.06% of oil-soluble azone, 0.3-0.4% of hydrogenated castor oil polyoxyethylene ether, 0.1-0.2% of penetrating agent JFC and the balance of distilled water.
3. The skin disinfectant combination according to claim 2, wherein the skin disinfectant liquid is prepared by a method comprising the steps of:
(1) mixing the traditional Chinese medicine extracting solution, thymol, borneol, menthol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone, hydrogenated castor oil polyoxyethylene ether and penetrant JFC according to a ratio, heating to 50-55 ℃, stirring until the mixture is dissolved and transparent, and continuously stirring for 10-15min at a constant temperature to obtain a first disinfection solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and ethanol, and stirring at normal temperature until the chlorhexidine acetate, the salicylic acid, the benzoic acid and the ethanol are dissolved and transparent to obtain a second disinfection solution;
(3) adding the first disinfectant solution into the second disinfectant solution, and stirring for 5-10 min;
(4) cooling to room temperature, supplementing water to 100%, stirring for 5-10min, and filtering to obtain the skin disinfectant.
4. The skin antiseptic combination of any one of claims 1-3 wherein the skin antiseptic solution comprises: 0.3-0.5% of chlorhexidine acetate, 0.9-1.1% of traditional Chinese medicine extracting solution, 0.05-0.14% of salicylic acid, 0.05-0.14% of benzoic acid, 6-8% of acetic acid, 0.05-0.5% of thymol, 0.05-0.08% of borneol, 0.02-0.05% of menthol, 2.2-2.5% of ethanol, 0.5-1% of propylene glycol, 0.01-0.1% of eucalyptus oil, 0.01-0.1% of wintergreen oil, 0.05-0.1% of oil-soluble azone, 1.1-1.5% of hydrogenated castor oil polyoxyethylene ether, 0-1% of malic acid, 0-1% of citric acid, 0-0.01% of cason and the balance of distilled water.
5. The skin antiseptic composition of claim 4 wherein the skin antiseptic solution is prepared by a method comprising the steps of:
(1) mixing the traditional Chinese medicine extract, thymol, borneol, menthol, ethanol, propylene glycol, eucalyptus oil, wintergreen oil, oil-soluble azone and hydrogenated castor oil polyoxyethylene ether according to a ratio, heating to 50-55 ℃, stirring until the mixture is completely dissolved and is transparent, and then continuously stirring for 15-20min at a constant temperature to obtain a first antibacterial solution;
(2) mixing chlorhexidine acetate, salicylic acid, benzoic acid and acetic acid, and stirring at normal temperature to be transparent to obtain a second antibacterial solution;
(3) mixing malic acid, citric acid and kasong, adding into distilled water with a weight of 3-5 times of the total weight of the mixture, and stirring until the mixture is completely dissolved to obtain a third antibacterial solution;
(4) adding the first antibacterial solution into the second antibacterial solution, stirring for 5-10min, adding the third antibacterial solution, and stirring for 5-10 min; supplementing water to 100%, stirring for 5-10min, cooling to room temperature, and filtering to obtain the skin antibacterial liquid.
6. The skin disinfectant combined preparation according to claim 2 or 4, wherein said Chinese medicinal extract is prepared by extracting Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis, cortex pseudolaricis, cortex Dictamni Radicis and radix Stemonae at a mass ratio of 1: 6-10: 1-5: 1-5: 6-10: 1-5: 1-5: 1-5.
7. The combined medicament for skin disinfection according to claim 6, wherein the preparation method of the Chinese herbal medicine extract comprises the following steps:
(1) boiling Coptidis rhizoma, cortex Phellodendri, fructus Cnidii, fructus Toosendan, radix Sophorae Flavescentis and cortex Dictamni Radicis with 3-5 times of pure water for 2-3 times, each for 2 hr; mixing the extractive solutions, concentrating into paste, dissolving with 95% ethanol, standing for 20-26 hr, filtering with 1um membrane, and collecting filtrate;
(2) pulverizing cortex pseudolaricis and radix Stemonae into powder, soaking in 5-10 times of 70% ethanol for 45-50 hr, filtering with 1um membrane, and collecting filtrate;
(3) mixing the filtrates obtained in the steps (1) and (2), and adjusting the density to 0.85 with 95% ethanol to obtain the Chinese medicinal extractive solution.
8. A method for preparing a skin sanitizing combination as described in any one of claims 1 to 7 comprising the steps of:
(1) preparing potassium peroxymonosulfate disinfection powder:
mixing 50-60% of potassium hydrogen peroxymonosulfate composite salt, 1.2-1.5% of citric acid, 1-11% of malic acid, 3-5% of sulfamic acid, 26-29% of sodium hexametaphosphate, 4-5% of sodium dodecyl benzene sulfonate and 1.3-1.8% of sodium chloride for 15-20min, sampling, inspecting, discharging, subpackaging, sealing and storing;
wherein the preparation conditions are as follows: the indoor temperature is reduced to below 30 ℃ and the relative humidity is below 20 percent;
(2) preparing a skin disinfectant;
(3) preparing skin antibacterial liquid;
(4) iodine disinfection solution: medical iodophor with effective iodine content of 0.45-0.55%.
9. The use of a skin sanitizing combination as described in any one of claims 1 to 7, comprising the steps of:
(1) for beriberi (tinea pedis), the skin of the foot has no cracks and no wound:
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the skin antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
secondly, repeating the step I for 1 to 2 times every day, and continuously applying the medicine until the symptoms completely disappear;
thirdly, the sports shoes, the walking shoes, the socks and the foot bath basin are soaked in potassium hydrogen peroxymonosulfate disinfection powder solution with the concentration of 3-5g/L for 20 minutes, and then are cleaned and dried;
fourthly, before going out, the skin disinfectant is used for spraying the inner surfaces of the feet, the socks and the shoes for one time;
(2) for onychomycosis (onychomycosis), the skin of foot has no crack and no wound;
firstly, taking 200-400ml of skin antibacterial liquid, adding 1-2 times of warm water, soaking feet for 10-20 minutes, wiping dry or cleaning with warm water, collecting the foot antibacterial liquid, sealing and storing, and repeatedly using for 2-3 times;
scraping off soft diseased nails by using a nail clipper, and coating an iodophor disinfectant solution;
thirdly, repeating the step 1-2 times every day, and continuously applying the medicine until the symptoms completely disappear;
soaking sports shoes, walking shoes, socks and foot bath tub in 3-5g/L potassium monopersulfate solution for 20min, washing and drying;
before going out, the feet and socks are sprayed with skin disinfectant once.
10. The use of the skin sanitizing combination according to claim 9, wherein for a skin lesion: the wound is smeared with iodophor disinfectant for 1-2 times every day, and after healing, the wound is disinfected according to the method (1) or the method (2).
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