CN105267866A - Emulsion for treating onychomycosis and preparation method of emulsion for treating onychomycosis - Google Patents
Emulsion for treating onychomycosis and preparation method of emulsion for treating onychomycosis Download PDFInfo
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Abstract
The invention discloses an emulsion for treating onychomycosis and a preparation method of the emulsion for treating onychomycosis. The emulsion contains eucalyptus oil, curcuma zedoary oil, oleum fructus bruceae, eugenol, self-emulsifying hybrid emulsifier AC-402, olive emulsifying agent, urea, salicylic acid, camphor, borneol, CMC-Na (sodium carboxyl methyl cellulose), sodium alginate, azone, boric acid, glycerol, hydroxypropyl methyl cellulose, 1,2-propanediol, fennel, lightyellow sophora root and a 5% ethylparaben propanediol solution. The emulsion for treating onychomycosis, prepared by the preparation method, has the advantages that the emulsion is high in functionality and little in toxicity or irritation, wherein the oleum fructus bruceae is capable of inhibiting fungus reproduction and effectively stopping fungal infection, a lightyellow sophora root extracting solution has anti-inflammatory and antibacterial effects, and all ingredients in the formula complement one another; compared with traditional medicines, the emulsion is better in treatment effect, higher in permeability and capable of avoiding relapse more effectively, thereby being capable of fundamentally treating onychomycosis caused by various fungi.
Description
Technical field
The present invention relates to one and treat tinea unguium Emulsion and preparation method thereof, belong to art of pharmacy.
Background technology
Because the tinea unguium caused by fungal infection becomes the worry of more and more people in actual life, and for a long time, the diagnoses and treatment mode of tinea unguium is all more single, and therapeutic effect is all not satisfactory, and recurrence becomes a treatment difficult problem repeatedly.
The reason of tinea unguium morbidity mainly contains three major types: individual factor, environmental factors, disease factor.
One, individual factor
1, Personal hygiene is not noted; 2, tinea manus and pedis is suffered from; 3, directly contact with water or chemicals for a long time; 4, dietetic patient; 5, fingernail is by wound or impact, may cause fungus intrusion; 6, often contact with tinea unguium (tinea unguium) patient.
Two, environmental factors
Temperature is high, high humidity is the multiple essential condition of tinea.Therefore, the tinea in summer, rainy season is more and heavy than winter, dry season.Work, the living environment of patient are also very important.In high temperature, high humidity workshop, particularly must wear that thick and heavy working clothing could be produced and the poor environment that ventilates easily suffers from tinea, if without having a bath equipment or fail to take a shower in time, then tinea sickness rate will significantly improve.
Three, disease factor
The tinea of some chronic disease as malnutrition, hyperthyroidism, diabetics is much shown in, symptom also lays particular stress on.Some serious symptoms, as acquired immune deficiency syndrome (AIDS), patient with advanced cancer, not only fungoid tinea sickness rate is high, and tinea is widely distributed, shows peculiar, and plain stubborn difficulty more.
Toxic action is less, and the Chinese medicine ingredients that Antifungi ability is stronger adds in the stronger Emulsion of the permeability for preparing the worry that effectively can solve tinea unguium and bring to.
Summary of the invention
The object of the present invention is to provide that a kind of toxic action is little, the strong and Emulsion of the treatment tinea unguium that permeability is strong and preparation method thereof of Antifungi ability.
A kind of Emulsion for the treatment of tinea unguium of the present invention, wherein includes the material of following consumption:
In the Emulsion for the treatment of tinea unguium described above, also include the material of following dosage:
In the Emulsion for the treatment of tinea unguium described above, described Radix Sophorae Flavescentis extractive liquid prepares by the following method: get Radix Sophorae Flavescentis 2-15g, be ground into coarse powder, divide and extract for three times: the soak with hydrochloric acid 5-30min adding 150-200ml0.1%-0.5% for the first time, 0.5-2h is extracted with reflux extraction, collect extracting solution, second time adds the hydrochloric acid extraction 0.5-2h of 130-150ml0.1%-0.5%, collect extracting solution, add the hydrochloric acid extraction 0.5-1h of 100-120ml0.1%-0.5% for the third time, each filtration, merges three filtrates, and mixing is concentrated into 10-90ml.Wherein, the hydrochloric acid of 0.1%-0.5% is volumetric concentration.
In the Emulsion for the treatment of tinea unguium described above, described Fructus Foeniculi extracting solution prepares by the following method: get Fructus Foeniculi 2-15g, be ground into coarse powder, divide and extract for three times: first time adds 200-300ml70%-80% soak with ethanol 5-30min, 0.5-1.5h is extracted with reflux extraction, collect extracting solution, second time adds 150-200ml70%-80% ethanol extraction 0.2-1h, collect extracting solution, third time adds 100-150ml70%-80% ethanol extraction 0.2-1h, each filtration, merges three filtrates, and mixing is concentrated into 10-90ml.Wherein, 70%-80% ethanol is volumetric concentration.
In the Emulsion for the treatment of tinea unguium described above,
In the Emulsion for the treatment of tinea unguium described above, preferably, the material of following consumption is included:
The preparation method of the Emulsion for the treatment of tinea unguium of the present invention, comprises the steps:
A) take sodium alginate, be scattered in 10-15ml distilled water, be fully swelled into transparent gel A;
B) take sodium carboxymethyl cellulose, be scattered in 6-10ml distilled water, be fully swelled into transparent gel B;
C) take hydroxypropyl emthylcellulose, be scattered in 6-10ml distilled water, be fully swelled into transparent gel C;
D) eucalyptus oil, Oleum Curcumae, Oleum Fructus Bruceae, eugenol, self emulsifying mixed emulsifier AC-402, Fructus Canarii albi emulsifying agent is taken in beaker 1,60-90 DEG C of heating in water bath, as oil phase, for subsequent use;
E) distilled water 1-10ml is measured in beaker 2,60-90 DEG C of heating in water bath, as aqueous phase, for subsequent use;
F) be that thread shape adds in beaker 1 by the distilled water in beaker 2, limit edged stirs towards same direction, forms emulsion bases a, for subsequent use;
G) in emulsion bases a, add gel A, gel B, gel C, form substrate b, for subsequent use;
H) carbamide, salicylic acid, boric acid are scattered in 1-6ml distilled water, form solution a, for subsequent use;
I) Camphora, Borneolum Syntheticum are scattered in 1-5ml75% ethanol, form solution b, for subsequent use;
J) in substrate b, add solution a, solution b, azone, glycerol, 1,2-PD, Fructus Foeniculi extracting solution, Radix Sophorae Flavescentis extractive liquid, 5% ethyl hydroxybenzoate alcoholic solution, be uniformly mixed, the Emulsion of tinea unguium must be treated.
The present invention with self emulsifying mixed emulsifier AC-402 and Fructus Canarii albi emulsifying agent for emulsifying agent, with sodium carboxymethyl cellulose, sodium alginate, hydroxypropyl emthylcellulose for emulsion stabilizer, with glycerol, 1,2-PD for co-emulsifier.Described 5% ethyl hydroxybenzoate alcoholic solution is weight concentration, and wherein alcohol can be ethanol, propylene glycol, glycerol etc.
Various compositions in the present invention are as follows:
Eucalyptus oil has the effect of antagonism virus, the most effective to respiratory tract disease, can relax inflammation phenomenon, make nasal mucosa comfortable.Particularly helpful especially to sinusitis, influenza, cough, rhinitis, asthma and pulmonary tuberculosis.Have obvious effect to scald, pre-bacteriological protection, fungus grow and the thing followed stores pus, promote neoblastic construction.Incised wound, wound, ulcer and inflammation situation, all react good after using eucalyptus globolus.
Oleum Fructus Bruceae permeable depths skin, Antifungi.Its main component oleic acid, it can suppress topoisomerase (TOPOII) active, thus the synthesis of T suppression cell DNA and growth, block the propagation of fungus.
Oleum Curcumae has a broad antifungal spectrum, has antibacterial action to skin wire-like bacteria, candidiasis, yeast, black filamentous bacteria, aspergillus, Penicillium, actinomycetes etc.Also there is antibacterial activity to some gram positive bacteria simultaneously.Its mechanism of action is the cell membrane acting on pathogenic bacterium, changes its permeability, stops nutrition intake, causes it dead.
Eugenol has very strong inhibitory action to food pollutant bacteria staphylococcus aureus, escherichia coli, Bacillus subtillis, Hansenula yeast, aspergillus niger, penicillium sp etc.Eugenol drips people's dental caries chamber on a small quantity, except performance disinfective action, and destroys its nerve, thus eases toothache.His-and-hers watches dermophyte also can suppress.
Carbamide is a kind of useful moisturizing ingredient, in the middle of the horny layer that it is just present in skin, belongs to the main component of skin nature moisturizing factor NMF.Concerning skin, carbamide has effect of moisturizing and soft cutin, thus the infiltration of auxiliary effective ingredient.
Salicylic acid can chafe, mucosa, peels off after cornea can be made to breed because reacting with the protein in body tissue.
Be rich in matrine in Radix Sophorae Flavescentis, matrine has antipathogen effect, also has inhibitory action to tubercule bacillus.
Containing effective ingredient such as volatile oil, organic acid, flavonoid, methoxybenzene, anisaldehydes in Fructus Foeniculi, there is good inhibitory action to escherichia coli, dysentery bacterium etc.The harmful levels of pathogens killing gastrointestinal tract and epidermis can be helped, promote the recovery from illness of inflammation and ulcer.
Camphora is applied to skin gentle stimulation and antisepsis.Firmly embrocate and sent out effect red; Dab is similar Herba Menthae then.Camphora also has inhibitory action to common causative fungus, can improve local blood circulation, can promote mucosal secretions.
Borneolum Syntheticum can suppress or kill the clinical common bacterias such as staphylococcus aureus, beta hemolytic streptococcus, viridans streptococci, Borneolum Syntheticum also has antibacterial action to 5 kinds of Common fungi such as red mentagrophytes, its action principle and Borneolum Syntheticum are easily through cell wall, cause cell membrane damage, destroy and change that it is permeability-related.
The Emulsion of the treatment tinea unguium prepared by the present invention is by force functional, and toxicity, zest are little.Oleum Fructus Bruceae can be bred by Antifungi, effectively stops fungal infection.Radix Sophorae Flavescentis extractive liquid then has antiinflammatory, antibiotic effect.Each composition in formula complements each other.Compare conventional medicament, therapeutic effect is better, and permeability is stronger, and recurrent is lower, fundamentally treats the tinea unguium caused by various fungus.
Detailed description of the invention
Following embodiment further illustrates using as the explaination to the technology of the present invention content for content of the present invention; but flesh and blood of the present invention is not limited in described in following embodiment, those of ordinary skill in the art can and should know any simple change based on connotation of the present invention or replace all should belong to protection domain of the presently claimed invention.
The preparation of 1 Fructus Foeniculi extracting solution
Get Radix Sophorae Flavescentis 15g, be ground into coarse powder, divide and extract for three times: first time adds 200ml0.2% soak with hydrochloric acid 30min, extract 2h with reflux extraction, collecting by filtration extracting solution, second time adds 150ml0.2% hydrochloric acid extraction 2h in filtering residue, collecting by filtration extracting solution, third time adds 120ml0.2% hydrochloric acid extraction 1h in filtering residue, merges three filtrates, and mixing is concentrated into 90ml.
The preparation of 2 Radix Sophorae Flavescentis extractive liquids
Get Fructus Foeniculi 15g, be ground into coarse powder, divide and extract for three times: first time adds 300ml75% soak with ethanol 30min, extracts 1.5h with reflux extraction, collect extracting solution, second time adds 200ml75% ethanol extraction 1h in filtering residue, collect extracting solution, third time adds 150ml75% ethanol extraction 1h in filtering residue, filters at every turn, merge three filtrates, mixing is concentrated into 90ml.
Embodiment 1
The preparation method for the treatment of tinea unguium Emulsion
A) take sodium alginate 0.04g, be scattered in 10ml distilled water, be fully swelled into transparent gel A:
B) take sodium carboxymethyl cellulose 0.05g, be scattered in 6ml distilled water, be fully swelled into transparent gel B:
C) take hydroxypropyl emthylcellulose 0.06g, be scattered in 6ml distilled water, be fully swelled into transparent gel C:
D) eucalyptus oil 1.0g, Oleum Curcumae 0.7g, Oleum Fructus Bruceae 0.6g, 1.0g self emulsifying mixed emulsifier AC-402,0.5g Fructus Canarii albi emulsifying agent is taken in beaker 1,90 DEG C of heating in water bath, as oil phase, for subsequent use;
E) distilled water 8ml is measured in beaker 2,90 DEG C of heating in water bath, as aqueous phase, for subsequent use;
Etc. f) oil phase, aqueous phase reach identical temperature, and be that thread shape adds in beaker 1 by the distilled water in beaker 2, limit edged stirs towards same direction, form emulsion bases a, for subsequent use;
G) in emulsion bases a, add gel A, gel B, gel C, form substrate b, for subsequent use;
H) 0.5g carbamide, 0.3g salicylic acid, 0.2g boric acid are scattered in 6ml distilled water, form solution a, for subsequent use;
I) 0.5g Camphora, 0.5g Borneolum Syntheticum are scattered in 5ml75% ethanol, form solution b, for subsequent use;
J) in substrate b, solution a, solution b, azone 0.1g, glycerol 5ml, 1 is added, 2-propylene glycol 5ml, Fructus Foeniculi extracting solution 5ml, Radix Sophorae Flavescentis extractive liquid 5ml, 5% ethyl hydroxybenzoate propylene glycol solution 4ml, be uniformly mixed, the Emulsion of tinea unguium must be treated.
Embodiment 2
The preparation method for the treatment of tinea unguium Emulsion
A) take sodium alginate 0.05g, be scattered in 12ml distilled water, be fully swelled into transparent gel A.
B) take sodium carboxymethyl cellulose 0.10g, be scattered in 10ml distilled water, be fully swelled into transparent gel B;
C) take hydroxypropyl emthylcellulose 0.12g, be scattered in 10ml distilled water, be fully swelled into transparent gel C;
D) eucalyptus oil 0.8g, Oleum Curcumae 0.6g, Oleum Fructus Bruceae 0.6g, 1.0g self emulsifying mixed emulsifier AC-402,0.4g Fructus Canarii albi emulsifying agent is taken in beaker 1,80 DEG C of heating in water bath, as oil phase, for subsequent use;
E) distilled water 10ml is measured in beaker 2,80 DEG C of heating in water bath, as aqueous phase, for subsequent use;
Etc. f) oil phase, aqueous phase reach identical temperature, and be that thread shape adds in beaker 1 by the distilled water in beaker 2, limit edged stirs towards same direction, form emulsion bases a, for subsequent use;
G) in emulsion bases a, add gel A, gel B, gel C, form substrate b, for subsequent use;
H) 0.4g carbamide, 0.2g salicylic acid, 0.1g boric acid are scattered in 5ml distilled water, form solution a, for subsequent use;
I) 1g Camphora, 0.5g Borneolum Syntheticum are scattered in 5ml75% ethanol, form solution b, for subsequent use;
J) in substrate b, solution a, solution b, azone 0.05g, glycerol 4ml, 1 is added, 2-propylene glycol 4ml, Fructus Foeniculi extracting solution 4ml, Radix Sophorae Flavescentis extractive liquid 4ml, 5% ethyl hydroxybenzoate propylene glycol solution 3ml, be uniformly mixed, the Emulsion of tinea unguium must be treated.
Embodiment 3
The preparation method for the treatment of tinea unguium Emulsion
A) take sodium alginate 0.06g, be scattered in 15ml distilled water, be fully swelled into transparent gel A;
B) take sodium carboxymethyl cellulose 0.07g, be scattered in 10ml distilled water, be fully swelled into transparent gel B;
C) take hydroxypropyl emthylcellulose 0.12g, be scattered in 10ml distilled water, be fully swelled into transparent gel C;
D) eucalyptus oil 1.0g, Oleum Curcumae 0.7g, Oleum Fructus Bruceae 0.6g, 0.8g self emulsifying mixed emulsifier AC-402,0.5g Fructus Canarii albi emulsifying agent is taken in beaker 1,90 DEG C of heating in water bath, as oil phase, for subsequent use;
E) distilled water 8ml is measured in beaker 2,90 DEG C of heating in water bath, as aqueous phase, for subsequent use;
Etc. f) oil phase, aqueous phase reach identical temperature, and be that thread shape adds in beaker 1 by the distilled water in beaker 2, limit edged stirs towards same direction, form emulsion bases a, for subsequent use;
G) in emulsion bases a, add gel A, gel B, gel C, form substrate b, for subsequent use;
H) 0.4g carbamide, 0.2g salicylic acid, 0.2g boric acid are scattered in 6ml distilled water, form solution a, for subsequent use;
I) 0.5g Camphora, 0.5g Borneolum Syntheticum are scattered in 5ml75% ethanol, form solution b, for subsequent use;
J) in substrate b, solution a, solution b, azone 0.1g, glycerol 5ml, 1 is added, 2-propylene glycol 3ml, Fructus Foeniculi extracting solution 3ml, Radix Sophorae Flavescentis extractive liquid 3ml, 5% ethyl hydroxybenzoate propylene glycol solution 4ml, be uniformly mixed, the Emulsion of tinea unguium must be treated.
Test example 1
The physical and chemical index of embodiment 1-3 gained Emulsion is as follows:
1 character
This product is light brown yellow, and viscosity is thinner, exquisiteness is even, the emulsion that stretchability is good.
2pH value checks
Get this product, measure with pH meter, recording pH value is between 6.8-7.0.
3 caloric tests
Emulsion is packaged in transparency emulsion bottle, within one month, observes without lamination in the refrigerator cold-storage of 4 DEG C.In the calorstat of 55 DEG C, put 24h, emulsion is without layering, the phenomenon such as spoiled.
4 centrifugal tests
Emulsion is packaged in the centrifugal 20min of 3000r/min in tool plug test tube, without lamination.
5 room temperatures place experiment
Embodiment Emulsion is placed in lotion pump, and room temperature leaves standstill investigation 6 months, without lamination, with after feel unchanged, abnormal smells from the patient is unchanged.
6 irritation tests, anaphylaxis are tested
White mice back cuts off hair, smears the Emulsion prepared by embodiment respectively in cutting plucked position, and is not coated with position and compares, and result does not have zest and anaphylaxis.
Example is applied in volunteer (16-50 year, 80 people) gesture and facial expression in right amount, observes, all do not occur rubescent, dermexanthesis, foaming phenomena after spending 30 minutes.
Test example 2
The resultant effect of embodiment of the present invention 1-3 gained treatment tinea unguium Emulsion is investigated.
Curative effect is below utilized to carry out the effect of the treatment tinea unguium Emulsion that Evaluation operation example 1-3 produces.Adopt public-opinion poll point system, choose 120 20-60 year age bracket patient as object on probation.Any decile three groups, is applied in affected part with the treatment tinea unguium Emulsion that embodiment 1,2,3 produces respectively.Every day uses twice, and service time is three months.Every result of use total score is 5 points: 5 be divided into best result, represents very well, very satisfaction; 4 are divided into better; 3 are divided into and can accept; Less than 3 points is bad, can not accept.It is below every average.The results are shown in Table 1:
Table 1 resultant effect is investigated
In sum, this product abnormal smells from the patient is good, fine and smooth, even, and treatment tinea unguium effect is better, and zest is little.
Claims (5)
1. treat an Emulsion for tinea unguium, wherein include the material of following consumption:
2. the Emulsion for the treatment of tinea unguium according to claim 1, is characterized in that, also includes the material of following dosage:
3. the Emulsion for the treatment of tinea unguium according to claim 1, it is characterized in that, described Radix Sophorae Flavescentis extractive liquid prepares by the following method: get Radix Sophorae Flavescentis 2-15g, be ground into coarse powder, divide and extract for three times: the soak with hydrochloric acid 5-30min adding 150-200ml0.1%-0.5% for the first time, 0.5-2h is extracted with reflux extraction, collect extracting solution, second time adds the hydrochloric acid extraction 0.5-2h of 130-150ml0.1%-0.5%, collect extracting solution, add the hydrochloric acid extraction 0.5-1h of 100-120ml0.1%-0.5% for the third time, each filtration, merge three filtrates, mixing is concentrated into 10-90ml.
4. the Emulsion for the treatment of tinea unguium according to claim 1, it is characterized in that, described Fructus Foeniculi extracting solution prepares by the following method: get Fructus Foeniculi 2-15g, be ground into coarse powder, divide and extract for three times: first time adds 200-300ml70%-80% soak with ethanol 5-30min, 0.5-1.5h is extracted with reflux extraction, collect extracting solution, second time adds 150-200ml70%-80% ethanol extraction 0.2-1h, collect extracting solution, third time adds 100-150ml70%-80% ethanol extraction 0.2-1h, each filtration, merge three filtrates, mixing is concentrated into 10-90ml.
5. the preparation method of the Emulsion of the treatment tinea unguium described in any one of claim 2-4, comprises the steps:
A) take sodium alginate, be scattered in 10-15ml distilled water, be fully swelled into transparent gel A;
B) take sodium carboxymethyl cellulose, be scattered in 6-10ml distilled water, be fully swelled into transparent gel B;
C) take hydroxypropyl emthylcellulose, be scattered in 6-10ml distilled water, be fully swelled into transparent gel C;
D) eucalyptus oil, Oleum Curcumae, Oleum Fructus Bruceae, eugenol, self emulsifying mixed emulsifier AC-402, Fructus Canarii albi emulsifying agent is taken in beaker 1,60-90 DEG C of heating in water bath, as oil phase, for subsequent use;
E) distilled water 1-10ml is measured in beaker 2,60-90 DEG C of heating in water bath, as aqueous phase, for subsequent use;
F) be that thread shape adds in beaker 1 by the distilled water in beaker 2, limit edged stirs towards same direction, forms emulsion bases a, for subsequent use;
G) in emulsion bases a, add gel A, gel B, gel C, form substrate b, for subsequent use;
H) carbamide, salicylic acid, boric acid are scattered in 1-6ml distilled water, form solution a, for subsequent use;
I) Camphora, Borneolum Syntheticum are scattered in 1-5ml75% ethanol, form solution b, for subsequent use;
J) in substrate b, add solution a, solution b, azone, glycerol, 1,2-PD, Fructus Foeniculi extracting solution, Radix Sophorae Flavescentis extractive liquid, 5% ethyl hydroxybenzoate alcoholic solution, be uniformly mixed, the Emulsion of tinea unguium must be treated.
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| CN105860235A (en) * | 2016-04-14 | 2016-08-17 | 巢湖市荷花渔网有限公司 | High-toughness acid-alkali-resistant fishing net |
| CN110833574A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | External preparation and preparation method thereof |
| CN111166841A (en) * | 2020-01-06 | 2020-05-19 | 成都润兴消毒药业有限公司 | Skin disinfection combined medicament and preparation method and use method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114796338B (en) * | 2022-05-07 | 2023-11-03 | 绍兴百立康医疗科技有限公司 | Gel for treating onychomycosis and preparation method thereof |
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| CN110833574A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | External preparation and preparation method thereof |
| CN111166841A (en) * | 2020-01-06 | 2020-05-19 | 成都润兴消毒药业有限公司 | Skin disinfection combined medicament and preparation method and use method thereof |
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| CN105267866B (en) | 2019-03-12 |
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Effective date of registration: 20191128 Address after: 430090 room 24, floor 6, building 5, Zhonghuan Hupan Zhenyuan, block 19c26, Wuhan Economic and Technological Development Zone, Wuhan City, Hubei Province Patentee after: Hubei Yijiang Pharmaceutical Co., Ltd Address before: 241000 No. 22 West Wenchang Road, Wuhu higher education zone, Anhui Patentee before: Wannan Medical College |