CN105267866B - A kind of emulsion and preparation method thereof for treating onychomycosis - Google Patents
A kind of emulsion and preparation method thereof for treating onychomycosis Download PDFInfo
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- CN105267866B CN105267866B CN201510753009.4A CN201510753009A CN105267866B CN 105267866 B CN105267866 B CN 105267866B CN 201510753009 A CN201510753009 A CN 201510753009A CN 105267866 B CN105267866 B CN 105267866B
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Abstract
The invention discloses a kind of emulsions and preparation method thereof for treating onychomycosis, it is contained the following substances in the emulsion: eucalyptus oil, oil of zedoary turmeric, brucea fruit oil, Eugenol, self-emulsifying mixed emulsifier AC-402, olive emulsifier, urea, salicylic acid, camphor, borneol, CMC-Na, sodium alginate, azone, boric acid, glycerol, hydroxypropyl methyl cellulose sodium, 1,2-PD, fennel, kuh-seng, 5% ethylparaben propylene glycol solution.Treatment onychomycosis lotion functional prepared by the present invention, toxicity, irritation are small.Brucea fruit oil can inhibit fungus breeding, effectively prevent fungal infection.Radix Sophorae Flavescentis extractive liquid then has anti-inflammatory, antibiotic effect.Each ingredient in formula complements each other.Compared to conventional medicament, therapeutic effect is more preferable, and permeability is stronger, and recurrent is lower, fundamentally treats the onychomycosis as caused by various fungies.
Description
Technical field
Onychomycosis emulsion and preparation method thereof is treated the present invention relates to a kind of, belongs to art of pharmacy.
Background technique
Because the onychomycosis caused by fungal infection becomes the worry of more and more people in actual life, and for a long time, ash refers to
The diagnoses and treatment mode of first be all it is relatively simple, therapeutic effect is all not satisfactory, repeatedly recurrence become treatment problem.
The reason of onychomycosis is fallen ill mainly has three categories: individual factor, environmental factor, disease factor.
One, individual factor
1, do not pay attention to personal hygiene；2, tinea of feet and hands is suffered from；3, it is directly contacted with water or chemicals for a long time；4, malnutritive
Person；5, nail may cause fungi intrusion by wound or impact；6, often with onychomycosis (onychomycosis) patient contact.
Two, environmental factor
Temperature is high, humidity is the multiple essential condition of tinea disease greatly.Therefore, the tinea disease in summer, rainy season more than winter, dry season and
Weight.The work of patient, living environment are also very important.In high temperature, high humidity workshop, particularly thick and heavy work clothes ability must be worn
Production and the poor environment of divulging information are susceptible to suffer from that tinea is sick, if without bathing equipment or failing to take a shower in time, tinea disease disease incidence will be mentioned obviously
It is high.
Three, disease factor
Certain chronic diseases such as malnutrition, hyperthyroidism, diabetic tinea it is sick much see, symptom is also inclined
Weight.Some severes, such as AIDS, patient with advanced cancer, not only fungoid tinea disease disease incidence is high, but also tinea disease is widely distributed, table
It is existing peculiar, it is plain stubborn refractory.
Toxic effect is smaller, inhibit the stronger traditional Chinese medicine ingredients of fungi ability to be added to the stronger cream of the permeability prepared
It will can effectively solve worry brought by onychomycosis in agent.
Summary of the invention
The purpose of the present invention is to provide a kind of toxic effects, and small, the inhibition treatment ash that fungi ability is strong and permeability is strong refers to
Emulsion of first and preparation method thereof.
A kind of emulsion for treating onychomycosis of the invention, wherein including the substance of following dosage:
Also include the substance of following dosage in the emulsion for the treatment of onychomycosis described above:
In the emulsion for the treatment of onychomycosis described above, the Radix Sophorae Flavescentis extractive liquid is prepared by the following method to obtain: taking
Kuh-seng 2-15g is ground into coarse powder, extracts in three times: adding the salt acid soak 5- of 150-200ml 0.1%-0.5% for the first time
30min extracts 0.5-2h with reflux extraction, collects extracting solution, the hydrochloric acid of second of addition 130-150ml0.1%-0.5%
0.5-2h is extracted, extracting solution is collected, third time is added the hydrochloric acid extraction 0.5-1h of 100-120ml 0.1%-0.5%, filters every time
It crosses, merges filtrate three times, mixing is concentrated into 10-90ml.Wherein, the hydrochloric acid of 0.1%-0.5% is volumetric concentration.
In the emulsion for the treatment of onychomycosis described above, the fennel extracting solution is prepared by the following method to obtain: taking
Fennel 2-15g is ground into coarse powder, extracts in three times: 200-300ml 70%-80% ethyl alcohol is added for the first time and impregnates 5-30min,
0.5-1.5h is extracted with reflux extraction, collects extracting solution, second of addition 150-200ml 70%-80% ethyl alcohol extracts 0.2-
1h collects extracting solution, and third time is added 100-150ml 70%-80% ethyl alcohol and extracts 0.2-1h, filters every time, and merging is filtered three times
Liquid, mixing are concentrated into 10-90ml.Wherein, 70%-80% ethyl alcohol is volumetric concentration.
In the emulsion for the treatment of onychomycosis described above,
In the emulsion for the treatment of onychomycosis described above, it is preferred that include the substance of following dosage:
The preparation method of the emulsion for the treatment of onychomycosis of the present invention, includes the following steps:
A) sodium alginate is weighed, is scattered in 10-15ml distilled water, transparent gel A is sufficiently swelled into；
B) sodium carboxymethylcellulose is weighed, is scattered in 6-10ml distilled water, transparent gel B is sufficiently swelled into；
C) hydroxypropyl methyl cellulose is weighed, is scattered in 6-10ml distilled water, transparent gel is sufficiently swelled into
C；
D) eucalyptus oil, oil of zedoary turmeric, brucea fruit oil, Eugenol, self-emulsifying mixed emulsifier AC-402, olive cream are weighed
Agent is in beaker 1, and 60-90 DEG C of heating water bath is spare as oily phase；
E) distilled water 1-10ml is measured in beaker 2, and 60-90 DEG C of heating water bath is spare as water phase；
F) distilled water in beaker 2 is added in beaker 1 in thread shape, side edged is stirred towards the same direction, forms cream
Agent matrix a, it is spare；
G) gel A, gel B, gel C are added into emulsion bases a, forms matrix b, it is spare；
H) it disperses urea, salicylic acid, boric acid in 1-6ml distilled water, forms solution a, it is spare；
I) it disperses camphor, borneol in 75% ethyl alcohol of 1-5ml, forms solution b, it is spare；
J) solution a, solution b, azone, glycerine, 1,2- propylene glycol, fennel extracting solution, kuh-seng are added into matrix b to extract
Liquid, 5% ethylparaben alcoholic solution are uniformly mixed to get the emulsion for the treatment of onychomycosis.
The present invention is using self-emulsifying mixed emulsifier AC-402 and olive emulsifier as emulsifier, with carboxymethyl cellulose
Sodium, sodium alginate, hydroxypropyl methyl cellulose are emulsion stabilizer, using glycerine, 1,2-PD as assistant for emulsifying agent.It is described
5% ethylparaben alcoholic solution is for weight concentration, and wherein alcohol can be ethyl alcohol, propylene glycol, glycerol etc..
Various composition in the present invention is as follows:
Eucalyptus oil plays the role of to antiviral, most effective to respiratory disease, can mitigate inflammation phenomenon, and schneiderian membrane is made to relax
It is suitable.It is especially especially helpful to nasosinusitis, influenza, cough, rheum, asthma and pulmonary tuberculosis.Have to scald bright
Aobvious effect, pre- bacteriological protection, fungi breed and the following storage purulence, promotes neoblastic construction.Incised wound, wound, ulcer and hair
Scorching situation, using reaction is good after You Jiali.
The permeable depths skin of brucea fruit oil inhibits fungi.Its main component oleic acid, it is able to suppress topoisomerase
(TOPOII) active, to inhibit the synthesis and growth of cell DNA, block the proliferation of fungi.
Oil of zedoary turmeric has a broad antifungal spectrum to skin wire-like bacteria, candida albicans, saccharomycete, black der Pilz, aspergillus, Penicillium, is put
Line bacterium etc. has antibacterial action.Also there is antibacterial activity to certain gram positive bacterias simultaneously.Its mechanism of action is to act on pathogenic bacteria
Cell membrane, change its permeability, prevent nutrition intake, lead to its death.
Eugenol is to food pollutant bacteria staphylococcus aureus, Escherichia coli, Bacillus subtillis, the inferior ferment of the Chinese
Mother, aspergillus niger, mould etc. have very strong inhibiting effect.Eugenol drips people's saprodontia chamber on a small quantity, in addition to playing disinfection, and breaks
Its bad nerve, to ease toothache.Epidermis fungi can also be inhibited.
Urea is a kind of useful moisturizing ingredient, it is present in the cuticula of skin, belongs to skin and naturally protects
The main component of wet factor NMF.For skin, urea has effects that moisturizing and soft cutin, thus auxiliary effectively at
The infiltration divided.
Salicylic acid can stimulate skin, mucous membrane, because can react with the protein in body tissue can make cornea be proliferated after
Removing.
Matrine is rich in kuh-seng, matrine has antipathogen effect, also has inhibiting effect to tubercle bacillus.
Containing effective components such as volatile oil, organic acid, flavonoids, anisole, anisaldehydes in fennel, to Escherichia coli, dysentery
Shigella etc. has good inhibiting effect.The disinfect pathogen of gastrointestinal tract and epidermis can be helped to kill, promote inflammation and ulcer
Recovery from illness.
Camphor, which is applied to skin, mild stimulation and antisepsis.It has firmly embrocated and has sent out effect red；Dab is then similar to peppermint.
Camphor also has inhibiting effect to common causative fungi, can improve local blood circulation, can promote mucosal secretions.
It is clinical common that borneol can inhibit or kill staphylococcus aureus, beta hemolytic streptococcus, viridans streptococci etc.
Bacterium, borneol also have antibacterial action to 5 kinds of Common fungis such as red mentagrophytes, and action principle and borneol easily penetrate cell wall, draw
Cell membrane damage is played, destroy and changes its is permeability-related.
The emulsion functional for the treatment of onychomycosis prepared by the present invention, toxicity, irritation are small.Brucea fruit oil can inhibit very
Bacterium breeding, effectively prevents fungal infection.Radix Sophorae Flavescentis extractive liquid then has anti-inflammatory, antibiotic effect.It is each at the auxiliary phase of split-phase in formula
At.Compared to conventional medicament, therapeutic effect is more preferable, and permeability is stronger, and recurrent is lower, fundamentally treats and is drawn by various fungies
The onychomycosis risen.
Specific embodiment
Following embodiments are further explanations for the content of present invention using as the explaination to the technology of the present invention content, but
Substantive content of the invention is not limited in described in following embodiments, those skilled in the art can with and should know appoint
What simple change or replacement based on true spirit should belong to protection scope of the presently claimed invention.
The preparation of 1 fennel extracting solution
Kuh-seng 15g is taken, coarse powder is ground into, is extracted in three times: 0.2% salt acid soak 30min of 200ml being added for the first time, is used
Reflux extraction extracts 2h, and extracting solution is collected by filtration, second of addition 0.2% hydrochloric acid extraction 2h of 150ml into filter residue, filtering
Extracting solution is collected, 0.2% hydrochloric acid extraction 1h of 120ml is added into filter residue for the third time, filtrate, mixing are concentrated into three times for merging
90ml。
The preparation of 2 Radix Sophorae Flavescentis extractive liquids
Fennel 15g is taken, coarse powder is ground into, is extracted in three times: 75% ethyl alcohol of 300ml being added for the first time and impregnates 30min, uses
Reflux extraction extracts 1.5h, collects extracting solution, and second of addition 75% ethyl alcohol of 200ml extraction 1h into filter residue is collected and extracted
Liquid is added 75% ethyl alcohol of 150ml into filter residue for the third time and extracts 1h, filters every time, filtrate, mixing are concentrated into three times for merging
90ml。
Embodiment 1
The preparation method for treating onychomycosis emulsion
A) sodium alginate 0.04g is weighed, is scattered in 10ml distilled water, transparent gel A is sufficiently swelled into:
B) sodium carboxymethylcellulose 0.05g is weighed, is scattered in 6ml distilled water, transparent gel is sufficiently swelled into
B:
C) hydroxypropyl methyl cellulose 0.06g is weighed, is scattered in 6ml distilled water, transparent coagulate sufficiently is swelled into
Glue C:
D) eucalyptus oil 1.0g, oil of zedoary turmeric 0.7g, brucea fruit oil 0.6g, 1.0g self-emulsifying mixed emulsifier AC- are weighed
402,0.5g olive emulsifier is in beaker 1, and 90 DEG C of heating water baths are spare as oily phase；
E) distilled water 8ml is measured in beaker 2, and 90 DEG C of heating water baths are spare as water phase；
Etc. f) oily phase, water phase reach mutually synthermal, by the distilled water in beaker 2 in thread shape addition beaker 1, side edged
It is stirred towards the same direction, forms emulsion bases a, it is spare；
G) gel A, gel B, gel C are added into emulsion bases a, forms matrix b, it is spare；
H) it disperses 0.5g urea, 0.3g salicylic acid, 0.2g boric acid in 6ml distilled water, forms solution a, it is spare；
I) it disperses 0.5g camphor, 0.5g borneol in 75% ethyl alcohol of 5ml, forms solution b, it is spare；
J) solution a, solution b, azone 0.1g, glycerine 5ml, 1,2- propylene glycol 5ml, fennel are added into matrix b to extract
Liquid 5ml, Radix Sophorae Flavescentis extractive liquid 5ml, 5% ethylparaben propylene glycol solution 4ml are uniformly mixed to get treatment onychomycosis
Emulsion.
Embodiment 2
The preparation method for treating onychomycosis emulsion
A) sodium alginate 0.05g is weighed, is scattered in 12ml distilled water, transparent gel A is sufficiently swelled into.
B) sodium carboxymethylcellulose 0.10g is weighed, is scattered in 10ml distilled water, transparent gel is sufficiently swelled into
B；
C) hydroxypropyl methyl cellulose 0.12g is weighed, is scattered in 10ml distilled water, transparent coagulate sufficiently is swelled into
Glue C；
D) eucalyptus oil 0.8g, oil of zedoary turmeric 0.6g, brucea fruit oil 0.6g, 1.0g self-emulsifying mixed emulsifier AC- are weighed
402,0.4g olive emulsifier is in beaker 1, and 80 DEG C of heating water baths are spare as oily phase；
E) distilled water 10ml is measured in beaker 2, and 80 DEG C of heating water baths are spare as water phase；
Etc. f) oily phase, water phase reach mutually synthermal, by the distilled water in beaker 2 in thread shape addition beaker 1, side edged
It is stirred towards the same direction, forms emulsion bases a, it is spare；
G) gel A, gel B, gel C are added into emulsion bases a, forms matrix b, it is spare；
H) it disperses 0.4g urea, 0.2g salicylic acid, 0.1g boric acid in 5ml distilled water, forms solution a, it is spare；
I) it disperses 1g camphor, 0.5g borneol in 75% ethyl alcohol of 5ml, forms solution b, it is spare；
J) solution a, solution b, azone 0.05g, glycerine 4ml, 1,2- propylene glycol 4ml, fennel are added into matrix b to extract
Liquid 4ml, Radix Sophorae Flavescentis extractive liquid 4ml, 5% ethylparaben propylene glycol solution 3ml are uniformly mixed to get treatment onychomycosis
Emulsion.
Embodiment 3
The preparation method for treating onychomycosis emulsion
A) sodium alginate 0.06g is weighed, is scattered in 15ml distilled water, transparent gel A is sufficiently swelled into；
B) sodium carboxymethylcellulose 0.07g is weighed, is scattered in 10ml distilled water, transparent gel is sufficiently swelled into
B；
C) hydroxypropyl methyl cellulose 0.12g is weighed, is scattered in 10ml distilled water, transparent coagulate sufficiently is swelled into
Glue C；
D) eucalyptus oil 1.0g, oil of zedoary turmeric 0.7g, brucea fruit oil 0.6g, 0.8g self-emulsifying mixed emulsifier AC- are weighed
402,0.5g olive emulsifier is in beaker 1, and 90 DEG C of heating water baths are spare as oily phase；
E) distilled water 8ml is measured in beaker 2, and 90 DEG C of heating water baths are spare as water phase；
Etc. f) oily phase, water phase reach mutually synthermal, by the distilled water in beaker 2 in thread shape addition beaker 1, side edged
It is stirred towards the same direction, forms emulsion bases a, it is spare；
G) gel A, gel B, gel C are added into emulsion bases a, forms matrix b, it is spare；
H) it disperses 0.4g urea, 0.2g salicylic acid, 0.2g boric acid in 6ml distilled water, forms solution a, it is spare；
I) it disperses 0.5g camphor, 0.5g borneol in 75% ethyl alcohol of 5ml, forms solution b, it is spare；
J) solution a, solution b, azone 0.1g, glycerine 5ml, 1,2- propylene glycol 3ml, fennel are added into matrix b to extract
Liquid 3ml, Radix Sophorae Flavescentis extractive liquid 3ml, 5% ethylparaben propylene glycol solution 4ml are uniformly mixed to get treatment onychomycosis
Emulsion.
Test example 1
The physical and chemical index of emulsion obtained by embodiment 1-3 is as follows:
1 character
This product is light brown yellow, and viscosity is leaner, fine and smooth uniform, the good lotion of stretchability.
2pH value inspection
This product is taken, is measured with pH meter, measures pH value between 6.8-7.0.
3 caloric tests
Emulsion is packaged in transparency emulsion bottle, in 4 DEG C of observations in refrigerator cold-storage one month without lamination.In 55 DEG C
Put in insulating box for 24 hours, lotion without layering, it is spoiled phenomena such as.
4 centrifugal tests
Emulsion is packaged in 3000r/min in tool plug test tube and is centrifuged 20min, no lamination.
5 are placed at room temperature for experiment
Embodiment emulsion is placed in lotion pump, investigation 6 months is stored at room temperature, no lamination feels unchanged after,
Smell is unchanged.
6 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears emulsion by embodiment preparation respectively in cutting plucked position, and do not apply position
It is compared, as a result without irritation and allergic reaction.
Example is applied in right amount in volunteer (16-50 years old, 80 people) gesture and facial expression, is observed after spending 30 minutes, is not sent out
It is red, dermexanthesis, foaming phenomena.
Test example 2
The resultant effect for the treatment of onychomycosis emulsion obtained by 1-3 of the embodiment of the present invention is investigated.
The effect for the treatment of onychomycosis emulsion that embodiment 1-3 is produced is evaluated following with curative effect.Using opinion poll
Point system chooses the patient of 120 20-60 years old age brackets as object on probation.Any three groups of equal part, respectively with embodiment 1,2,
The 3 treatment onychomycosis emulsions produced are applied to affected part.It uses daily twice, the use of the time is three months.Every using effect
It is best result that total score, which is 5 points: 5 points, is indicated very well, very satisfied；4 points are preferable；3 points are that can receive；3 points the following are not
It is good, it cannot receive.The following are every averages.It the results are shown in Table 1:
1 resultant effect of table is investigated
In conclusion this product smell is good, fine and smooth, uniform, treatment onychomycosis effect is preferable, and irritation is small.
Claims (2)
1. a kind of emulsion for treating onychomycosis, is made of the substance of following dosage:
The Radix Sophorae Flavescentis extractive liquid is prepared by the following method to obtain: kuh-seng 2-15g taken, coarse powder is ground into, is extracted in three times: the
Primary plus 150-200ml 0.1%-0.5% salt acid soak 5-30min extracts 0.5-2h with reflux extraction, collects and extract
Liquid, the hydrochloric acid extraction 0.5-2h of second of addition 130-150ml 0.1%-0.5% collect extracting solution, and 100- is added in third time
The hydrochloric acid extraction 0.5-1h of 120ml 0.1%-0.5% is filtered every time, merges filtrate three times, and mixing is concentrated into 10-90ml；
The fennel extracting solution is prepared by the following method to obtain: fennel 2-15g taken, coarse powder is ground into, is extracted in three times: the
The primary 200-300ml 70%-80% ethyl alcohol that is added impregnates 5-30min, extracts 0.5-1.5h with reflux extraction, collects and extract
Liquid, second of addition 150-200ml 70%-80% ethyl alcohol extract 0.2-1h, collect extracting solution, and 100-150ml is added in third time
70%-80% ethyl alcohol extracts 0.2-1h, filters every time, merges filtrate three times, and mixing is concentrated into 10-90ml.
2. the preparation method of the emulsion for the treatment of onychomycosis described in claim 1, includes the following steps:
A) sodium alginate is weighed, is scattered in 10-15ml distilled water, transparent gel A is sufficiently swelled into；
B) sodium carboxymethylcellulose is weighed, is scattered in 6-10ml distilled water, transparent gel B is sufficiently swelled into；
C) hydroxypropyl methyl cellulose is weighed, is scattered in 6-10ml distilled water, transparent gel C is sufficiently swelled into；
D) eucalyptus oil, oil of zedoary turmeric, brucea fruit oil, Eugenol, self-emulsifying mixed emulsifier AC-402, olive emulsifier are weighed
In beaker 1,60-90 DEG C of heating water bath is spare as oily phase；
E) distilled water 1-10ml is measured in beaker 2, and 60-90 DEG C of heating water bath is spare as water phase；
F) distilled water in beaker 2 is added in beaker 1 in thread shape, side edged is stirred towards the same direction, forms emulsion base
Matter a, it is spare；
G) gel A, gel B, gel C are added into emulsion bases a, forms matrix b, it is spare；
H) it disperses urea, salicylic acid, boric acid in 1-6ml distilled water, forms solution a, it is spare；
I) it disperses camphor, borneol in 75% ethyl alcohol of 1-5ml, forms solution b, it is spare；
J) into matrix b be added solution a, solution b, azone, glycerine, 1,2- propylene glycol, fennel extracting solution, Radix Sophorae Flavescentis extractive liquid,
5% ethylparaben alcoholic solution is uniformly mixed to get the emulsion for the treatment of onychomycosis.
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| CN114796338A (en) * | 2022-05-07 | 2022-07-29 | 绍兴百立康医疗科技有限公司 | Gel for treating onychomycosis and preparation method thereof |
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| CN105860235A (en) * | 2016-04-14 | 2016-08-17 | 巢湖市荷花渔网有限公司 | High-toughness acid-alkali-resistant fishing net |
| CN110833574A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | External preparation and preparation method thereof |
| CN111166841B (en) * | 2020-01-06 | 2022-09-23 | 成都润兴消毒药业有限公司 | Skin disinfection combined medicament and preparation method and use method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430962A (en) * | 2003-01-14 | 2003-07-23 | 朱富平 | Skin liniment |
| CN101474405A (en) * | 2009-01-20 | 2009-07-08 | 上海市杨浦区中心医院 | External-use preparation for treating onychomycosis |
-
2015
- 2015-11-04 CN CN201510753009.4A patent/CN105267866B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1430962A (en) * | 2003-01-14 | 2003-07-23 | 朱富平 | Skin liniment |
| CN101474405A (en) * | 2009-01-20 | 2009-07-08 | 上海市杨浦区中心医院 | External-use preparation for treating onychomycosis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796338A (en) * | 2022-05-07 | 2022-07-29 | 绍兴百立康医疗科技有限公司 | Gel for treating onychomycosis and preparation method thereof |
| CN114796338B (en) * | 2022-05-07 | 2023-11-03 | 绍兴百立康医疗科技有限公司 | Gel for treating onychomycosis and preparation method thereof |
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