CN114796338A - Gel for treating onychomycosis and preparation method thereof - Google Patents
Gel for treating onychomycosis and preparation method thereof Download PDFInfo
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- CN114796338A CN114796338A CN202210489313.2A CN202210489313A CN114796338A CN 114796338 A CN114796338 A CN 114796338A CN 202210489313 A CN202210489313 A CN 202210489313A CN 114796338 A CN114796338 A CN 114796338A
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- gel
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- ethanol
- extract
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- 208000010195 Onychomycosis Diseases 0.000 title claims abstract description 36
- 201000005882 tinea unguium Diseases 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 84
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 48
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 48
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 36
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 24
- 229960004889 salicylic acid Drugs 0.000 claims description 24
- 241000246044 Sophora flavescens Species 0.000 claims description 23
- 239000008213 purified water Substances 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 19
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 17
- 239000004327 boric acid Substances 0.000 claims description 17
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 16
- 239000004202 carbamide Substances 0.000 claims description 16
- 241000218691 Cupressaceae Species 0.000 claims description 13
- 229940037003 alum Drugs 0.000 claims description 13
- 239000000047 product Substances 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 8
- 239000002562 thickening agent Substances 0.000 claims description 8
- 239000008204 material by function Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 235000014145 Caesalpinia bonduc Nutrition 0.000 claims description 3
- 244000036978 Caesalpinia bonduc Species 0.000 claims description 3
- 235000016513 Caesalpinia crista Nutrition 0.000 claims description 3
- 229960002645 boric acid Drugs 0.000 claims description 2
- 239000013543 active substance Substances 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 230000004060 metabolic process Effects 0.000 abstract description 4
- 239000003960 organic solvent Substances 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 52
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 36
- 238000001914 filtration Methods 0.000 description 24
- 239000000706 filtrate Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 19
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 18
- 241000972673 Phellodendron amurense Species 0.000 description 16
- 239000000725 suspension Substances 0.000 description 16
- 239000013078 crystal Substances 0.000 description 13
- 230000020477 pH reduction Effects 0.000 description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 238000004821 distillation Methods 0.000 description 12
- ZSBXGIUJOOQZMP-UHFFFAOYSA-N Isomatrine Natural products C1CCC2CN3C(=O)CCCC3C3C2N1CCC3 ZSBXGIUJOOQZMP-UHFFFAOYSA-N 0.000 description 11
- ZSBXGIUJOOQZMP-JLNYLFASSA-N Matrine Chemical compound C1CC[C@H]2CN3C(=O)CCC[C@@H]3[C@@H]3[C@H]2N1CCC3 ZSBXGIUJOOQZMP-JLNYLFASSA-N 0.000 description 11
- 229930014456 matrine Natural products 0.000 description 11
- 238000010411 cooking Methods 0.000 description 10
- 238000001816 cooling Methods 0.000 description 10
- 239000003513 alkali Substances 0.000 description 9
- 238000001035 drying Methods 0.000 description 9
- 238000001125 extrusion Methods 0.000 description 9
- 238000003825 pressing Methods 0.000 description 9
- 238000002791 soaking Methods 0.000 description 9
- 238000004140 cleaning Methods 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 238000001694 spray drying Methods 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 6
- 238000007789 sealing Methods 0.000 description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical group [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- -1 scurenol Substances 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 239000002535 acidifier Substances 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000008187 granular material Substances 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- 238000010298 pulverizing process Methods 0.000 description 4
- 238000009210 therapy by ultrasound Methods 0.000 description 4
- 238000007605 air drying Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XVPBINOPNYFXID-JARXUMMXSA-N 85u4c366qs Chemical compound C([C@@H]1CCC[N@+]2(CCC[C@H]3[C@@H]21)[O-])N1[C@@H]3CCCC1=O XVPBINOPNYFXID-JARXUMMXSA-N 0.000 description 2
- 235000016061 Coriaria sinica Nutrition 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 229930015582 oxymatrine Natural products 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 235000001553 Betula platyphylla Nutrition 0.000 description 1
- 241001313086 Betula platyphylla Species 0.000 description 1
- 235000017595 Callicarpa japonica Nutrition 0.000 description 1
- 240000003690 Callicarpa japonica Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000972672 Phellodendron Species 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
- 229960004884 fluconazole Drugs 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- GNHOJBNSNUXZQA-UHFFFAOYSA-J potassium aluminium sulfate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GNHOJBNSNUXZQA-UHFFFAOYSA-J 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 201000009862 superficial mycosis Diseases 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
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- Communicable Diseases (AREA)
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Abstract
The invention belongs to the technical field of onychomycosis, and particularly relates to gel for treating onychomycosis and a preparation method thereof. The invention overcomes the defects of the existing gel, and utilizes the matching of the organic solvent and water, thereby not only achieving the purposes of carrying active substances to carry out permeation sterilization and bacteriostasis, but also promoting the internal and external absorption of the active substances, and achieving the purposes of promoting metabolism, relieving symptoms and treating onychomycosis.
Description
Technical Field
The invention belongs to the technical field of onychomycosis, and particularly relates to a gel for treating onychomycosis and a preparation method thereof.
Background
Onychomycosis is caused by dermatophyte invading the nail plate, the incidence rate of the onychomycosis accounts for more than 10% of superficial mycosis, the disease is common, the disease course is long, the pathological changes are stubborn and have infectivity. The nails become thick, brittle, loose and empty after infection; the surface is black, yellow, grey, white and the like, and particularly, the surface is suitable for the growth environment of fungi in areas with high air humidity and has higher morbidity
The existing methods for treating onychomycosis include oral medication, nail pulling therapy, external medication and the like. The oral medicines are usually used as antifungal medicines such as scurenol, hydrochloric acid terbinafine, fluconazole and the like, but the treatment course is long and has certain side effect on the body. The penetration of the external medicine to the nail plate is poor, and the external medicine cannot penetrate through the protective layer on the surface of the nail and penetrate to the nail or the deep layer of the nail plate to kill the fungi, so that the medicine after being used has the advantages of unobvious curative effect, slow effect taking, short drug effect time, difficult cure and easy relapse. Therefore, there is a need in the market for a drug for external use which is excellent in therapeutic effect and high in safety.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a gel for treating onychomycosis, which overcomes the defects of the existing gel, and not only can carry active substances to carry out osmotic sterilization and bacteriostasis, but also can promote the internal and external absorption of the active substances by utilizing the matching of an organic solvent and water, thereby achieving the purposes of promoting metabolism, relieving symptoms and treating onychomycosis.
In order to achieve the technical purpose, the technical scheme of the invention is as follows:
a gel for treating onychomycosis is prepared from salicylic acid, boric acid, Alumen, radix Sophorae Flavescentis extract, cortex Phellodendri, urea as functional materials, ZEN and SUNYUNSHIJIAO as thickening agent, and propylene glycol, purified water and ethanol water as solvent.
The gel comprises the following components in percentage by mass:
5-8 parts of salicylic acid, 2-6 parts of boric acid, 5-8 parts of alum, 3-7 parts of a sophora flavescens extract, 4-8 parts of golden cypress, 2-4 parts of urea, 5-10 parts of ZEN, 5-10 parts of corium versicolor, 10-20 parts of propylene glycol, 30-50 parts of purified water and 30-50 parts of an ethanol water solution.
The volume concentration of ethanol in the ethanol water solution is 70%.
The salicylic acid is a fat-soluble organic acid, exists in willow bark, beautyberry leaf and Betula platyphylla in nature, and has the effects of relieving itching, relieving swelling, alleviating pain and diminishing inflammation. Meanwhile, salicylic acid has good solubility in ethanol, and a good dispersion system is formed.
The boric acid can be used as an antiseptic and disinfectant, and has good bacteriostatic and antibacterial effects.
The alum is also called aluminum potassium sulfate dodecahydrate, is a double salt of potassium sulfate and aluminum sulfate containing crystal water, is soluble in water, has the giao functions of detoxifying, killing insects, eliminating dampness, relieving itching, stopping bleeding, relieving diarrhea, clearing heat and eliminating phlegm, and shows good antibacterial action and astringency when in use.
The sophora flavescens extract is obtained by extracting dry sophora flavescens, and the sophora flavescens extract not only has the functions of resisting virus, resisting allergy and the like, but also has good pathogen inhibition effect. The extraction method of the sophora flavescens extract comprises the following steps: a1, cleaning commercially available dried radix Sophorae Flavescentis with distilled water, air drying, and dicing to obtain radix Sophorae Flavescentis blocks; a2, adding the sophora flavescens blocks into an ethanol water solution, stirring and extruding to crush for 1-3h, then adding acetone and carrying out ultrasonic reaction for 2-4h to obtain a mixed suspension; the ethanol volume concentration of the ethanol aqueous solution is 60-70%, the mass ratio of the sophora flavescens blocks to the ethanol aqueous solution is 2-3:3, the extrusion crushing temperature is 30-50 ℃, the extrusion pressure is 0.3-0.5MPa, the addition amount of the acetone is 200-400% of the volume of the ethanol aqueous solution, and the ultrasonic reaction temperature is 30-40 ℃; in the step, the sophora flavescens block is soaked in an ethanol water solution to form swelling, and is crushed in the extrusion process, so that the exposed area is enhanced, the sophora flavescens block is ensured to be adsorbed and saturated to form swelling, only the dissolution characteristics of ethanol and water are realized, and the swelling and cracking of the dried sophora flavescens are matched, so that the dissolution effect is improved; with the addition of acetone, the matrine can directly act on sophora flavescens cells based on the fact that acetone has good intersolubility in water and ethanol, so that dissolution based on different organic solvents is formed; a3, carrying out gradient distillation on the mixed suspension, recovering ethanol and acetone to obtain a primary extract, carrying out acidification treatment on the primary extract for 2-3h, and filtering to obtain a filtrate, wherein hydrochloric acid is adopted as an acidifier in the acidification treatment, and the pH of the acidification treatment is 3-4; a4, adjusting the pH of the filtrate to 9-10 by using alkali liquor, filtering, and then distilling under reduced pressure to obtain a paste, wherein the alkali liquor is ammonia water, the temperature of the distillation under reduced pressure is 90-100 ℃, and the pressure is 80-90% of the atmospheric pressure; removing substances by means of acidification and alkalization, finally forming a paste mainly in an alkali state, simultaneously directly taking out solutes of hydrochloric acid and ammonia water which are volatile substances in reduced pressure distilled water, so as to ensure that the solutes do not form residues, a5, dissolving the paste in acetone, performing heat filtration, drying, adding petroleum ether, filtering, standing to obtain crystals, wherein the temperature of the heat filtration is 30-40 ℃, and removing impurities by means of dissolution filtration to form a compound extract mainly containing oxymatrine and matrine; the radix Sophorae Flavescentis extract obtained by this method has matrine as main ingredient, and oxymatrine as auxiliary ingredient, and has antibacterial and bacteriostatic effects and properties of both. In order to improve the purity of matrine in the crystal, putting the crystal into diethyl ether, performing ultrasonic treatment for 20-30min, filtering, and spray drying the filtrate to obtain matrine granule; the ultrasonic frequency is 40-50kHz, the temperature is 5-10 ℃, and the spray drying temperature is 40 ℃.
The cortex Phellodendri is cortex Phellodendri extract, and is extracted from bark of cortex Phellodendri. Cortex Phellodendri extract has effects of removing toxic substance and treating sore, and can be applied into nail rapidly. The extraction method of the golden cypress comprises the following steps: b1, cleaning and fastening the surface of the bark of the phellodendron amurense, then putting the phellodendron amurense into an ethanol water solution for soaking until the phellodendron amurense is completely softened, and crushing the phellodendron amurense to obtain suspension; the volume concentration of ethanol in the ethanol water solution is 30-40%, the soaking temperature is 25-45 ℃, and the pulverization is mechanically pulverized into filaments; b2, placing the suspension into a reaction kettle, hermetically cooking for 1-2h, cooling, and performing filter pressing to obtain filtrate, wherein the temperature of the hermetic cooking is 100-110 ℃, the pressure of the filter pressing is 0.3-0.5MPa, and the cooking mode can convert ethanol and water into a steam state to form a permeation effect, so that bark cells are opened, the effect of curing and diffusion is achieved, the liquid permeability is improved, and the problem of obstruction of cell walls is reduced; after cooling, substances in the bark are fully dissolved out, and most of removal effect is realized in filter pressing; b3, distilling the filtrate under reduced pressure to remove ethanol, and cooling and drying to obtain cortex Phellodendri extract, wherein the temperature of the distillation under reduced pressure is 70-80 deg.C, and the pressure is 80-90% of atmospheric pressure. The process utilizes a soaking and softening mode to completely absorb water and saturate bark, ensures that bark cells form a swelling effect, converts water and ethanol in a swelling system into steam in a cooking process, breaks cell walls to achieve the purpose of opening, provides a dissolution path for dissolution after subsequent cooling, and improves the dissolution effect.
The urea has good moisture retention and can effectively improve local humidity.
ZEN is ZEN from gathering the polymer, belongs to polyacrylic acid thickener, has good thickening effect.
The Caesalpinia crista gum belongs to a thickening agent and can play a role in thickening and improving water solubility.
The preparation method of the gel for treating the onychomycosis comprises the following steps:
step 1, heating ZEN, subcloud shell gum, propylene glycol and purified water to 60-70 ℃, and stirring for dissolving for 5min to obtain a first dissolved solution;
step 2, heating boric acid, alum, a radix sophorae flavescentis extract, golden cypress, urea and purified water to 60-70 ℃, and stirring for dissolving for 5min to obtain a second dissolved solution;
dissolving salicylic acid in an ethanol water solution at normal temperature to obtain a third dissolved solution, wherein the volume concentration of ethanol in the ethanol water solution is 70%;
step 4, uniformly mixing the first solution, the second solution and the third solution, stirring for 4 hours to form gel, namely the product
The gel is applied to the surface of the onychomycosis by adopting a wet wrapping mode.
In the use, propylene glycol, ethanol and water all have good flat effect of pasting, not only form complete the application on the onychomycosis surface, and self permeability and solubility can inwards permeate active substance, realize the effect of inside and outside absorption to reach the effect of strengthening metabolism, alum, boric acid, salicylic acid are the material formation antibacterial system that disinfects fast simultaneously, realize detumescence and diminish inflammation on nontoxic nonirritant basis.
From the above description, it can be seen that the present invention has the following advantages:
1. the invention overcomes the defects of the existing gel, and utilizes the matching of the organic solvent and water, thereby not only achieving the purposes of carrying active substances to carry out permeation sterilization and bacteriostasis, but also promoting the internal and external absorption of the active substances, and achieving the purposes of promoting metabolism, relieving symptoms and treating onychomycosis.
2. The invention utilizes ZEN and Caesalpinia crista gum to form the composite thickening agent, and is matched with multiple-effect debridement of different solvent systems, so that the wound surface is quickly cleaned, and the healing of the wound surface is facilitated.
3. The invention adopts the soluble salicylic acid to form the salicylic acid solution, thereby not only effectively improving the action surface of the salicylic acid and solving the problem of poor salicylic acid utilization rate, but also greatly improving the salicylic acid utilization rate by the salicylic acid forming a penetration effect along with the solvent.
Detailed Description
The present invention is described in detail with reference to examples, but the present invention is not limited to the claims.
Example 1
A gel for treating onychomycosis is prepared from salicylic acid, boric acid, Alumen, radix Sophorae Flavescentis extract, cortex Phellodendri, urea as functional materials, ZEN and SUNYUNSHIJIAO as thickening agent, and propylene glycol, purified water and ethanol water as solvent.
The gel comprises the following components in percentage by mass:
5 parts of salicylic acid, 2 parts of boric acid, 5 parts of alum, 3 parts of radix sophorae flavescentis extract, 4 parts of cortex phellodendri, 2-4 parts of urea, 5 parts of ZEN, 5 parts of corium versicolor, 10 parts of propylene glycol, 30 parts of purified water and 30-50 parts of ethanol water solution.
The volume concentration of ethanol in the ethanol water solution is 70%.
The radix Sophorae Flavescentis extract is obtained by extracting dried radix Sophorae Flavescentis. The extraction method of the sophora flavescens extract comprises the following steps: a1, cleaning commercially available dried radix Sophorae Flavescentis with distilled water, air drying, and dicing to obtain radix Sophorae Flavescentis blocks; a2, adding the sophora flavescens blocks into an ethanol water solution, stirring and extruding to crush for 1h, then adding acetone and carrying out ultrasonic reaction for 2h to obtain a mixed suspension; the ethanol volume concentration of the ethanol aqueous solution is 60%, the mass ratio of the sophora flavescens blocks to the ethanol aqueous solution is 2:3, the extrusion crushing temperature is 30 ℃, the extrusion pressure is 0.3MPa, the addition amount of acetone is 200% of the volume of the ethanol aqueous solution, and the ultrasonic reaction temperature is 30 ℃; a3, carrying out gradient distillation on the mixed suspension, recovering ethanol and acetone to obtain a primary extract, carrying out acidification treatment on the primary extract for 2 hours, and filtering to obtain a filtrate, wherein hydrochloric acid is adopted as an acidifying agent in the acidification treatment, and the pH of the acidification treatment is 3; a4, adjusting the pH value of the filtrate to 9 by using alkali liquor, filtering, distilling under reduced pressure to obtain paste, wherein the alkali liquor adopts ammonia water, the temperature of the reduced pressure distillation is 90 ℃, and the pressure is 80% of the atmospheric pressure, a5, dissolving the paste in acetone, carrying out heat filtration, drying, adding petroleum ether, filtering, standing to obtain crystals, and the temperature of the heat filtration is 30 ℃. In order to improve the purity of matrine in the crystal, putting the crystal into ether, performing ultrasonic treatment for 20min, filtering, and spray drying the filtrate to obtain matrine granules; the ultrasonic frequency is 40kHz, the temperature is 5 ℃, and the spray drying temperature is 40 ℃.
The cortex Phellodendri is cortex Phellodendri extract, and is extracted from bark of cortex Phellodendri. The extraction method of the golden cypress comprises the following steps: b1, cleaning and fastening the surface of the bark of the phellodendron amurense, then putting the phellodendron amurense into an ethanol water solution for soaking until the phellodendron amurense is completely softened, and crushing the phellodendron amurense to obtain suspension; the volume concentration of ethanol in the ethanol water solution is 30%, the soaking temperature is 25 ℃, and the pulverization is mechanically pulverized into filaments; b2, placing the suspension into a reaction kettle, sealing, cooking and boiling for 1h, cooling, and performing filter pressing to obtain filtrate, wherein the sealing, cooking and boiling temperature is 100 ℃, and the filter pressing pressure is 0.3 MPa; b3, distilling the filtrate under reduced pressure to remove ethanol, and cooling and drying to obtain cortex Phellodendri extract, wherein the temperature of the distillation under reduced pressure is 70 deg.C, and the pressure is 80% of atmospheric pressure.
The preparation method of the gel for treating the onychomycosis comprises the following steps:
step 1, heating ZEN, subcloud shell gum, propylene glycol and purified water to 60 ℃, and stirring for dissolving for 5min to obtain a first dissolved solution;
step 2, heating boric acid, alum, a radix sophorae flavescentis extract, golden cypress, urea and purified water to 60 ℃, and stirring for dissolving for 5min to obtain a second dissolved solution;
dissolving salicylic acid in an ethanol water solution at normal temperature to obtain a third dissolved solution;
step 4, uniformly mixing the first solution, the second solution and the third solution, stirring for 4 hours to form gel, namely the product
The gel is applied to the surface of the onychomycosis by adopting a wet wrapping mode.
Example 2
A gel for treating onychomycosis is prepared from salicylic acid, boric acid, Alumen, radix Sophorae Flavescentis extract, cortex Phellodendri, urea as functional materials, ZEN and SUNYUNSHIJIAO as thickening agent, and propylene glycol, purified water and ethanol water as solvent.
The gel comprises the following components in percentage by mass:
8 parts of salicylic acid, 6 parts of boric acid, 8 parts of alum, 7 parts of radix sophorae flavescentis extract, 8 parts of golden cypress, 4 parts of urea, 10 parts of ZEN, 10 parts of coriaria sinica gum, 20 parts of propylene glycol, 50 parts of purified water and 50 parts of ethanol water solution.
The volume concentration of ethanol in the ethanol water solution is 70%.
The radix Sophorae Flavescentis extract is obtained by extracting dried radix Sophorae Flavescentis. The extraction method of the sophora flavescens extract comprises the following steps: a1, cleaning commercially available dried radix sophorae flavescentis by using distilled water, drying in the air and dicing to obtain radix sophorae flavescentis blocks; a2, adding the sophora flavescens blocks into an ethanol water solution, stirring and extruding to crush for 3 hours, then adding acetone and carrying out ultrasonic reaction for 4 hours to obtain a mixed suspension; the ethanol volume concentration of the ethanol aqueous solution is 70%, the mass ratio of the sophora flavescens blocks to the ethanol aqueous solution is 3:3, the extrusion crushing temperature is 50 ℃, the extrusion pressure is 0.5MPa, the addition amount of acetone is 400% of the volume of the ethanol aqueous solution, and the ultrasonic reaction temperature is 40 ℃; a3, carrying out gradient distillation on the mixed suspension, recovering ethanol and acetone to obtain a primary extract, then carrying out acidification treatment on the primary extract for 3 hours, and filtering to obtain a filtrate, wherein hydrochloric acid is adopted as an acidifying agent in the acidification treatment, and the pH value of the acidification treatment is 4; a4, adjusting the pH value of the filtrate to 10 by using alkali liquor, filtering, distilling under reduced pressure to obtain paste, wherein the alkali liquor adopts ammonia water, the temperature of the reduced pressure distillation is 100 ℃, the pressure is 90% of the atmospheric pressure, a5, the paste is put into acetone to be dissolved and filtered, petroleum ether is added after drying, filtering is carried out, standing is carried out to obtain crystals, and the temperature of the heat filtering is 40 ℃. In order to improve the purity of matrine in the crystal, putting the crystal into ether, performing ultrasonic treatment for 30min, filtering, and spray drying the filtrate to obtain matrine granules; the ultrasonic frequency is 50kHz, the temperature is 10 ℃, and the spray drying temperature is 40 ℃.
The cortex Phellodendri is cortex Phellodendri extract, and is extracted from bark of cortex Phellodendri. The extraction method of the golden cypress comprises the following steps: b1, cleaning and fastening the surface of the bark of the phellodendron amurense, then putting the phellodendron amurense into an ethanol water solution for soaking until the phellodendron amurense is completely softened, and crushing the phellodendron amurense to obtain suspension; the volume concentration of ethanol in the ethanol water solution is 40%, the soaking temperature is 45 ℃, and the pulverization is mechanically pulverized into filaments; b2, placing the suspension into a reaction kettle, sealing, cooking for 2 hours, cooling, and performing filter pressing to obtain filtrate, wherein the sealing, cooking temperature is 110 ℃, and the pressure of the filter pressing is 0.5 MPa; b3, distilling the filtrate under reduced pressure to remove ethanol, and cooling and drying to obtain cortex Phellodendri extract, wherein the temperature of the distillation under reduced pressure is 80 deg.C, and the pressure is 90% of atmospheric pressure.
The preparation method of the gel for treating the onychomycosis comprises the following steps:
step 1, heating ZEN, subcloud shell gum, propylene glycol and purified water to 70 ℃, and stirring for dissolving for 5min to obtain a first dissolved solution;
step 2, heating boric acid, alum, a radix sophorae flavescentis extract, golden cypress, urea and purified water to 70 ℃, and stirring for dissolving for 5min to obtain a second dissolved solution;
step 3, dissolving salicylic acid in an ethanol water solution at normal temperature to obtain a third dissolved solution,
step 4, uniformly mixing the first solution, the second solution and the third solution, stirring for 4 hours to form gel, namely the product
The gel is applied to the surface of the onychomycosis by adopting a wet wrapping mode.
Example 3
A gel for treating onychomycosis is prepared from salicylic acid, boric acid, Alumen, radix Sophorae Flavescentis extract, cortex Phellodendri, urea as functional materials, ZEN and SUNYUNSHIJIAO as thickening agent, and propylene glycol, purified water and ethanol water as solvent.
The gel comprises the following components in percentage by mass:
7 parts of salicylic acid, 5 parts of boric acid, 5 parts of alum, 5 parts of a sophora flavescens extract, 7 parts of golden cypress, 3 parts of urea, 8 parts of ZEN, 8 parts of coriaria sinica gum, 15 parts of propylene glycol, 50 parts of purified water and 50 parts of ethanol water solution.
The volume concentration of ethanol in the ethanol water solution is 70%.
The radix Sophorae Flavescentis extract is obtained by extracting dried radix Sophorae Flavescentis. The extraction method of the sophora flavescens extract comprises the following steps: a1, cleaning commercially available dried radix Sophorae Flavescentis with distilled water, air drying, and dicing to obtain radix Sophorae Flavescentis blocks; a2, adding the sophora flavescens blocks into an ethanol water solution, stirring and extruding to crush for 2 hours, then adding acetone and carrying out ultrasonic reaction for 3 hours to obtain a mixed suspension; the ethanol volume concentration of the ethanol aqueous solution is 65%, the mass ratio of the sophora flavescens blocks to the ethanol aqueous solution is 2:3, the extrusion crushing temperature is 40 ℃, the extrusion pressure is 0.4MPa, the addition amount of acetone is 300% of the volume of the ethanol aqueous solution, and the ultrasonic reaction temperature is 35 ℃; a3, carrying out gradient distillation on the mixed suspension, recovering ethanol and acetone to obtain a primary extract, carrying out acidification treatment on the primary extract for 2 hours, and filtering to obtain a filtrate, wherein hydrochloric acid is adopted as an acidifying agent in the acidification treatment, and the pH of the acidification treatment is 3; a4, adjusting the pH value of the filtrate to 10 by using alkali liquor, filtering, distilling under reduced pressure to obtain paste, wherein the alkali liquor adopts ammonia water, the temperature of the reduced pressure distillation is 90 ℃, and the pressure is 80% of the atmospheric pressure, a5, dissolving the paste in acetone, carrying out heat filtration, drying, adding petroleum ether, filtering, standing to obtain crystals, and the temperature of the heat filtration is 35 ℃. In order to improve the purity of matrine in the crystal, putting the crystal into diethyl ether, performing ultrasonic treatment for 25min, filtering, and spray drying the filtrate to obtain matrine granule; the ultrasonic frequency is 45kHz, the temperature is 5 ℃, and the spray drying temperature is 40 ℃.
The cortex Phellodendri is cortex Phellodendri extract, and is extracted from bark of cortex Phellodendri. The extraction method of the golden cypress comprises the following steps: b1, cleaning and fastening the surface of the bark of the phellodendron amurense, then putting the phellodendron amurense into an ethanol water solution for soaking until the phellodendron amurense is completely softened, and crushing the phellodendron amurense to obtain suspension; the volume concentration of ethanol in the ethanol water solution is 30-40%, the soaking temperature is 40 ℃, and the pulverization is mechanically pulverized into filaments; b2, placing the suspension into a reaction kettle, sealing, cooking for 2 hours, cooling, and performing filter pressing to obtain filtrate, wherein the sealing, cooking temperature is 105 ℃, and the pressure of the filter pressing is 0.4 MPa; b3, distilling the filtrate under reduced pressure to remove ethanol, and cooling and drying to obtain cortex Phellodendri extract, wherein the temperature of the distillation under reduced pressure is 75 deg.C, and the pressure is 85% of atmospheric pressure.
The preparation method of the gel for treating the onychomycosis comprises the following steps:
step 1, heating ZEN, subcloud shell gum, propylene glycol and purified water to 65 ℃, and stirring for dissolving for 5min to obtain a first dissolved solution;
step 2, heating boric acid, alum, a sophora flavescens extract, phellodendron, urea and purified water to 65 ℃, and stirring for dissolving for 5min to obtain a second dissolved solution;
dissolving salicylic acid in an ethanol water solution at normal temperature to obtain a third dissolved solution, wherein the volume concentration of ethanol in the ethanol water solution is 70%;
step 4, uniformly mixing the first solution, the second solution and the third solution, stirring for 4 hours to form gel, namely the product
The gel is applied to the surface of the onychomycosis by adopting a wet wrapping mode.
The following tests were carried out using the products of examples 1 to 3 described above as test examples:
1. the product is fine and uniform, and has good absorbability and spreadability.
2. The pH value of the product is about 7.
3. The gel was packed in a sealed bottle and no foreign body was found neither by freezing (-5 ℃) nor by temperature (50 ℃).
4. 100 onychomycosis patients aged 15 to 65 years were selected, with the following main symptoms: diseased nails are brown, grayish brown or dark brown, and thickened and embrittled nail plates, or hollow middle layers of nail plates, uneven nail margins, incomplete nail plates and the like can be seen. Randomized into 3 groups of 20 people each. Each group is coated with the gel prepared in examples 1-3 for 30min, and is administered once in the morning and at night, with 30 days as a treatment course, and 4 treatment courses are total. The ashed nails were shaved with a knife before application and every other week during treatment.
Statistics shows that the total effective rate of the product in the example 1 is 100%, and the significant effect proportion is 70%. The total effective rate of the product of example 2 is 100%, and the significant effective rate is 85%. The total effective rate of the product of example 3 is 100%, and the proportion of significant effects is 75%.
The nail polish has the obvious effects that the surface fungus detection is negative, the nail color is normal and glossy, the surface fullness fungus detection is positive, and the color of the newly born nail is slightly different, glossy and poor in glossiness. Ineffectiveness is no apparent change before and after use.
It should be understood that the detailed description of the invention is merely illustrative of the invention and is not intended to limit the invention to the specific embodiments described. It will be appreciated by those skilled in the art that the present invention may be modified or substituted equally as well to achieve the same technical result; as long as the use requirements are met, the method is within the protection scope of the invention.
Claims (7)
1. A gel for treating onychomycosis, comprising: salicylic acid, boric acid, alum, a radix sophorae flavescentis extract, golden cypress and urea are used as functional materials, ZEN and corium versicolor are used as thickening agents, and propylene glycol, purified water and an ethanol water solvent are used as solvents.
2. The gel for treating onychomycosis according to claim 1, wherein: the gel comprises the following components in percentage by mass:
5-8 parts of salicylic acid, 2-6 parts of boric acid, 5-8 parts of alum, 3-7 parts of a sophora flavescens extract, 4-8 parts of golden cypress, 2-4 parts of urea, 5-10 parts of ZEN, 5-10 parts of corium versicolor, 10-20 parts of propylene glycol, 30-50 parts of purified water and 30-50 parts of an ethanol water solution.
3. The gel for treating onychomycosis according to claim 1, wherein: the volume concentration of ethanol in the ethanol water solution is 70%.
4. The gel for treating onychomycosis according to claim 1, wherein: the radix Sophorae Flavescentis extract is obtained by extracting dried radix Sophorae Flavescentis.
5. The gel for treating onychomycosis according to claim 1, wherein: the cortex Phellodendri is cortex Phellodendri extract, and is extracted from bark of cortex Phellodendri.
6. The gel for treating onychomycosis according to claim 1, wherein: the preparation method of the gel for treating the onychomycosis comprises the following steps:
step 1, heating ZEN, Caesalpinia crista gum, propylene glycol and purified water to 60-70 ℃, and stirring and dissolving for 5min to obtain a first dissolved solution;
step 2, heating boric acid, alum, a radix sophorae flavescentis extract, golden cypress, urea and purified water to 60-70 ℃, and stirring for dissolving for 5min to obtain a second dissolved solution;
dissolving salicylic acid in an ethanol water solution at normal temperature to obtain a third dissolved solution, wherein the volume concentration of ethanol in the ethanol water solution is 70%;
and 4, uniformly mixing the first solution, the second solution and the third solution, and stirring for 4 hours to form a gel, namely the product.
7. The gel for treating onychomycosis according to claim 1, wherein: the gel is applied to the surface of the onychomycosis by adopting a wet wrapping mode.
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| CN115778877A (en) * | 2022-12-19 | 2023-03-14 | 北京同仁堂麦尔海生物技术有限公司 | Acne removing composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664379A (en) * | 2009-09-22 | 2010-03-10 | 南京白敬宇制药有限责任公司 | Salicylic acid gelling agent and preparation method thereof |
| CN105267866B (en) * | 2015-11-04 | 2019-03-12 | 皖南医学院 | A kind of emulsion and preparation method thereof for treating onychomycosis |
| CN107496792B (en) * | 2017-08-29 | 2020-05-26 | 皖南医学院 | Gel for treating onychomycosis by diminishing inflammation and resisting bacteria and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664379A (en) * | 2009-09-22 | 2010-03-10 | 南京白敬宇制药有限责任公司 | Salicylic acid gelling agent and preparation method thereof |
| CN105267866B (en) * | 2015-11-04 | 2019-03-12 | 皖南医学院 | A kind of emulsion and preparation method thereof for treating onychomycosis |
| CN107496792B (en) * | 2017-08-29 | 2020-05-26 | 皖南医学院 | Gel for treating onychomycosis by diminishing inflammation and resisting bacteria and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115778877A (en) * | 2022-12-19 | 2023-03-14 | 北京同仁堂麦尔海生物技术有限公司 | Acne removing composition |
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