CN109223736A - Composition, the drug and preparation method thereof for preventing and treating animal foot rot - Google Patents
Composition, the drug and preparation method thereof for preventing and treating animal foot rot Download PDFInfo
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- CN109223736A CN109223736A CN201811162882.6A CN201811162882A CN109223736A CN 109223736 A CN109223736 A CN 109223736A CN 201811162882 A CN201811162882 A CN 201811162882A CN 109223736 A CN109223736 A CN 109223736A
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- drug
- foot rot
- animal foot
- thymol
- glutaraldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The present invention relates to a kind of compositions for preventing and treating animal foot rot, drug and preparation method thereof, wherein the effective component for preventing and treating the composition of animal foot rot includes glutaraldehyde, quaternary ammonium salt and Thymol.The composition low toxicity, irritation are small, no pollution to the environment, and to humans and animals safety, play synergistic function by glutaraldehyde, Thymol and quaternary ammonium salt compounding, strengthen bactericidal property, can effectively prevent animal foot rot.
Description
Technical field
The present invention relates to disinfectant for animals technical fields, more particularly to a kind of composition, medicine for preventing and treating animal foot rot
Object and preparation method thereof.
Background technique
Foot rot is called inter-hoof rot or interdigitalis rot, autumn susceptible disease, be artiodactyl such as ruminant especially ox,
A kind of common highly contagious disease of sheep aquaculture is that hoof qualitative change is soft, rotten bleeding by causing in necrobacillus intrusion hoof seam
Purulent secretion out leads to local organization inflammation, necrosis.Foot rot is one of the important diseases for influencing animal productiong, to animal
Harm it is very big, all surface goes out higher disease incidence throughout our country, and disease incidence is up to 30%~40% in drylot feeding cows.The disease
Generation not only influence cow producing milk and movement, serious person frequently results in milk cow and eliminates.Foot rot is mainly because cattle pen is excessively damp
Wet, hoof leads to cutin softening by fecaluria dipping for a long time, and infection and necrosis bacillus is caused caused by inter-hoof rot.In addition cow hoof is broken
Stone, foreign matter stubble point etc. are fenced by dirt after stabbing, and form anoxic conditions, and the factor of this disease occurs.
On veterinary clinic, hoof is mainly bathed using foot paring, copper-bath at present, and carry out using antibiotic such as penicillin
Treatment, although these control measures have certain curative effect to milk cow, foot rot of sheep, foot paring is inconvenient and time-consuming and laborious, and
Copper-bath has certain stimulation to animal and easily pollutes the environment, long-time service antibiotic be easy to produce drug resistance and
Antibiotic residue is easily led to, there are security risks.Therefore, people are still in the drug for constantly looking for and researching and developing new prevention and treatment foot rot
With new administration route with more convenient medication, raising curative effect.
Summary of the invention
Based on this, a kind of glutaraldehyde, quaternary ammonium salt and Thymol composition for preventing and treating animal foot rot is provided, it can be effective
Prevention and treatment animal foot rot.
A kind of composition for preventing and treating animal foot rot, including following effective component: glutaraldehyde, quaternary ammonium salt and Thymol.
The composition low toxicity of the above-mentioned prevention and treatment animal foot rot of the present invention, irritation are small, no pollution to the environment, and to people and move
Object safety plays synergistic function by glutaraldehyde, Thymol and quaternary ammonium salt compounding, strengthens bactericidal property, can
Effectively prevent animal foot rot.Wherein, glutaraldehyde has high-efficiency broad spectrum bactericidal effect, is capable of fixing albumen, is crosslinked by it
Effect destroys phage surface protein receptor, so that membrane protein configuration is changed, protein function is affected, and then plays sterilization
Effect, it might even be possible to kill gemma；The effects of Thymol tool is antibacterial, anti-oxidant and anti-inflammatory, since Thymol has lipophilic
Property, being able to enter cell membrane causes phospholipid bilayer structure disturbance, expression and the Metabolism of Citric Acid access of protein are influenced, from
And cause thallus dead；The quaternary ammonium cation of quaternary ammonium salt can be in conjunction with phosphate negatively charged in phosphatide, so as to actively
It adsorbs negatively charged bacterium, fungi and virus and covers its surface, generating chamber's inhibition effect hinders the growth metabolisms such as bacterium and dead
It dies, while permeability of cell membranes can also be changed, Medicated Permeation is promoted to enter the organization internal of bacterium, fungi and virus, destroy
The activity of protein and enzyme reinforces drug effect.
The quaternary ammonium salt is Deciquam in one of the embodiments,.
The mass ratio of the glutaraldehyde and the Thymol is (5~10) in one of the embodiments: 1.
The glutaraldehyde and the mass ratio of the Deciquam are 1:(0.8~1.2 in one of the embodiments).
The inventive concept total as one, the present invention also provides a kind of drugs for preventing and treating animal foot rot, by quality percentage
Than meter, mainly it is prepared from the following raw materials: 2%~8% glutaraldehyde, 2%~8% quaternary ammonium salt, 0.1%~10% thyme
Phenol and 74%~95.5% solvent.
In one of the embodiments, by mass percentage, the drug of the prevention and treatment animal foot rot is mainly by following
Raw material is made: 3%~6% glutaraldehyde, 3%~6% quaternary ammonium salt, 0.5%~5% Thymol and 83%~93.5%
Solvent.
The solvent is selected from one of water, ethyl alcohol and propylene glycol in one of the embodiments,.
The raw material of the drug further includes emollient in one of the embodiments,.
Further, the emollient is selected from least one of polyol, vegetable oil, mineral oil and free fatty acid.
Another object of the present invention is to provide a kind of preparation method of the drug of above-mentioned prevention and treatment animal foot rot, including following
Step:
According to the raw material proportioning of the drug of the prevention and treatment animal foot rot, each raw material component is uniformly mixed.
Further include the steps that in one of the embodiments, using when the drug is diluted with water after use liquid, institute
Stating drug and diluting the mass ratio of water used is 1:(100~5000).
Above-mentioned preparation method, easy to operate, safety, required equipment is simple, and products obtained therefrom quality is stablized, and is easy to industry
Metaplasia produces.
Specific embodiment
To facilitate the understanding of the present invention, below will to invention is more fully described, and give it is of the invention compared with
Good embodiment.But the invention can be realized in many different forms, however it is not limited to embodiment described herein.Phase
Instead, purpose of providing these embodiments is makes the disclosure of the present invention more thorough and comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more phases
Any and all combinations of the listed item of pass.
A kind of composition of prevention and treatment animal foot rot of an embodiment of the present invention, including following effective component: glutaraldehyde,
Quaternary ammonium salt and Thymol.
Glutaraldehyde has high-efficiency broad spectrum bactericidal effect, is capable of fixing albumen, is crosslinked work by it as aldehyde disinfectant
With destruction phage surface protein receptor makes membrane protein configuration change, and protein function is affected, and then plays sterilization and make
With, it might even be possible to kill gemma.
Thymol (thymol) is initially isolated from thyme, have good aroma and it is antibacterial, anti-oxidant and
The effects of anti-inflammatory.Studies have shown that Thymol antimicrobial mechanism is to be able to enter somatic cells film since it is with lipophilicity and cause
Phospholipid bilayer structure disturbance, influences expression and the Metabolism of Citric Acid access of protein, to cause thallus dead.While hundred
In fragrant phenol there is antioxidation, can be improved the stability of composition system.
The quaternary ammonium cation of quaternary ammonium salt can be negative so as to actively adsorb band in conjunction with phosphate negatively charged in phosphatide
Bacterium, fungi and the virus of charge simultaneously cover its surface, generating chamber's inhibition effect, hinder the growth metabolisms such as bacterium and dead, simultaneously
Can also change permeability of cell membranes, Medicated Permeation is promoted to enter the organization internal of bacterium, fungi and virus, destroy protein and
The activity of enzyme reinforces drug effect.
The composition low toxicity of above-mentioned prevention and treatment animal foot rot, irritation are small, no pollution to the environment, and pacify to humans and animals
Entirely, synergistic function is played by glutaraldehyde, Thymol and quaternary ammonium salt compounding, the addition of Thymol can reduce penta
The use dosage of dialdehyde and quaternary ammonium salt reduces product irritation, while keeping significant bactericidal property, can effectively prevent dynamic
Object foot rot.
In one embodiment, quaternary ammonium salt be selected from dodecyl trimethyl ammonium chloride, dodecyl benzyl dimethyl ammonium chloride,
At least one of Deciquam and dodecyl dimethyl benzyl ammonium bromide.
More preferably, quaternary ammonium salt is Deciquam.For Deciquam as double-chain quaternary ammonium salt disinfectant, quaternary ammonium cation can
In conjunction with phosphate negatively charged in somatic cells membrane phospholipid, to actively attract negatively charged thallus and really cover its table
Face hinders the growth metabolism of microorganism, and bromide ion makes the hydrophily and lipophilicity enhancing of molecule, and the disinfection reached rapidly and efficiently is made
With；Meanwhile Deciquam can change the permeability of somatic cells film as cationic surfactant, promote Medicated Permeation
Into thallus organization internal, reinforce drug effect.
In one embodiment, the mass ratio of glutaraldehyde and Thymol is (5~10): 1.
In one embodiment, glutaraldehyde and the mass ratio of Deciquam are 1:(0.8~1.2).
A kind of drug of prevention and treatment animal foot rot of another embodiment of the present invention, by mass percentage, mainly by with
Lower raw material is made: 2%~8% glutaraldehyde, 2%~8% quaternary ammonium salt, 0.1%~10% Thymol and 74%~
95.5% solvent.
It is appreciated that Thymol can be added in said medicine with purified form；Alternatively, can will include thyme
The thyme linaloe oil of phenol or thyme extract etc. include that the active matter of Thymol is added in said medicine, while ensuring hundred
In fragrant phenol in required effective concentration drug existing in this application.Thyme linaloe oil or thyme extract are obtained from thyme, ox
To and the plants such as clore basil.
More preferably, Thymol is added in the form of thyme plant extract.
In one embodiment, by mass percentage, the drug for preventing and treating animal foot rot is mainly prepared from the following raw materials:
3%~6% glutaraldehyde, 3%~6% quaternary ammonium salt, 0.5%~5% Thymol and 83%~93.5% solvent.
In one embodiment, solvent is selected from one of water, ethyl alcohol and propylene glycol.
More preferably, solvent is water.In this way, on the other hand can be saved into not being that solvent is on the one hand non-stimulated to animal
This.
In one embodiment, the raw material for preventing and treating the drug of animal foot rot further includes emollient.
In one embodiment, emollient is selected from least one of polyol, plant object oil, mineral oil and free fatty acid.
Wherein, polyol preferably is selected from glycerol and/or D-sorbite；Vegetable oil preferably be selected from sunflower oil, corn oil, apricot kernel oil,
Or mixtures thereof seed oil of Moringa oleigera, tea oil；Free fatty acid preferably is selected from babassu oil fatty acid or lauric acid.
More preferably, emollient is seed oil of Moringa oleigera.It is appreciated that seed oil of Moringa oleigera on the one hand can be with moisturizing, it on the other hand can be with
Softening animal cuticle cell promotes also have certain bactericidal effect while Medicated Permeation, so as to promote the sterilization of drug
Disinfection.
In one embodiment, the additive amount of emollient accounts for the 1%~20% of drug gross mass.
In one embodiment, the drug of animal foot rot is prevented and treated, by mass percentage, is mainly prepared from the following raw materials,
3%~5% glutaraldehyde, 3%~5% Deciquam, 0.5%~5% Thymol, 1%~5% seed oil of Moringa oleigera and
83%~92.5% solvent.
Another embodiment of the present invention provides a kind of preparation method of the drug of above-mentioned prevention and treatment animal foot rot, including following
Step:
According to the raw material proportioning of the drug of above-mentioned prevention and treatment animal foot rot, each component is uniformly mixed.
Specifically, glutaraldehyde, quaternary ammonium salt, Thymol etc. are mixed with solvent, slowly at the uniform velocity stirring to each component dissolves
Completely and it is uniformly mixed.
More specifically, at room temperature, glutaraldehyde, quaternary ammonium salt, Thymol etc. are dissolved in solvent respectively respectively, then
Each lysate is mixed, is stirred evenly.
In one embodiment, further include the steps that using when drug is diluted with water to obtain using liquid, drug and dilution institute
It is 1:(100~5000 with the mass ratio of water).It is appreciated that extension rate can be selected according to the concentration of effective component in drug
It selects, as long as specifically, passing through making after dilution after meeting dilution using the concentration of effective component in liquid in effective range
Final mass percent concentration with glutaraldehyde in liquid is 0.005ppm~0.5ppm, the final mass percent concentration of quaternary ammonium salt
For 0.005ppm~0.5ppm, the final mass percent concentration of Thymol is 0.0002ppm~1ppm.Preferably, it dilutes
The multiple of concentration is seriously selected according to disease, specifically, when prophylactic, by using glutaraldehyde in liquid after dilution
Final mass percent concentration be 0.005ppm~0.025ppm, the final mass percent concentration of quaternary ammonium salt is 0.005ppm
~0.025ppm, the final mass percent concentration of Thymol are 0.0002ppm~0.05ppm.When disease occurs, by dilute
The final mass percent concentration using glutaraldehyde in liquid after releasing is 0.05ppm~0.5ppm, the final mass hundred of quaternary ammonium salt
Dividing specific concentration is 0.05ppm~0.5ppm, and the final mass percent concentration of Thymol is 0.025ppm~1ppm.
Above-mentioned preparation method, reaction condition is mild, and easy to operate, safety, required equipment is simple, products obtained therefrom quality
Stablize, it is easy to industrialized production.
The following are specific embodiments
Embodiment 1
The formula for preventing and treating the drug of animal foot rot are as follows: 5wt% glutaraldehyde+5wt% Deciquam+0.5wt% thyme
Phenol, surplus are water.
(1) each raw material component is accurately weighed, wherein the raw material of Thymol is thyme plant extract, and weight is with hundred
In the content of fragrant phenol convert.
(2) at room temperature, glutaraldehyde, Deciquam and thyme plant extract are dissolved in suitable quantity of water respectively, so
Each solvent soln is uniformly mixed afterwards.
Embodiment 2
Embodiment 2 is substantially the same manner as Example 1, the difference is that, the formula of the drug of embodiment 2 are as follows: 3wt% penta 2
Aldehyde+3wt% Deciquam+1wt% Thymol, surplus is water.
Comparative example 1
Comparative example 1 is common chemosterilant, the i.e. copper-bath of 10wt%.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 1, the difference is that, without Thymol in the drug of comparative example 2.
Comparative example 3
Comparative example 3 is substantially the same manner as Example 1, the difference is that, without Deciquam in the drug of comparative example 3.
Embodiment 3
Embodiment 3 is substantially the same manner as Example 1, the difference is that, the formula of the drug of embodiment 3 are as follows: 3wt% penta 2
Aldehyde+3wt% Deciquam+0.5wt% Thymol+1wt% seed oil of Moringa oleigera, surplus is water.
Embodiment 4
Embodiment 4 is substantially the same manner as Example 2, the difference is that, the formula of the drug of embodiment 4 are as follows: 2wt% penta 2
Aldehyde+2wt% Deciquam+4wt% Thymol+1wt% seed oil of Moringa oleigera, surplus is water.
Embodiment 5
Embodiment 5 is substantially the same manner as Example 1, the difference is that, the formula of the drug of embodiment 5 are as follows: 5wt% penta 2
Aldehyde+5wt% Deciquam+0.5wt% Thymol+1wt% tea oil, surplus is water.
Embodiment 6
Embodiment 6 is substantially the same manner as Example 2, the difference is that, the formula of the drug of embodiment 6 is 5wt% penta 2
Aldehyde+5wt% dodecyl trimethyl ammonium chloride+0.5wt% Thymol+1wt% seed oil of Moringa oleigera, surplus is water.
Embodiment 7
Embodiment 7 is substantially the same manner as Example 2, the difference is that, the formula of medicinal group of object of embodiment 7 is 5wt%
Glutaraldehyde+5wt% dodecyl dimethyl benzyl ammonium bromide+0.5wt% Thymol+1wt% seed oil of Moringa oleigera, surplus is water.
Embodiment 8
Embodiment 8 is substantially the same manner as Example 3, the difference is that, the formula of the drug of embodiment 8 are as follows: 3wt% penta 2
Aldehyde+2wt% Deciquam+0.5wt% Thymol+1wt% seed oil of Moringa oleigera, surplus is water.
Effect proof property test
This test is carried out in Zhaoqing cattle farm Jun Bin.
Experimental animal: foot rot milk cow is suffered from selection.
Case selection standard: having obvious limping symptom, suffer from hoof flush, swelling, pain, again and again act limb, and hoof bottom goes out
Existing corrupt hole not of uniform size, surrounding necrotic tissue are in dirty grey or dark brown, and hole flows out the foot rots diseases such as stench liquid
Shape, suffers from that ox performance spirit is depressed, and body temperature is increased up to 40 DEG C, milk production decline.
Test grouping: the drug of above-described embodiment 1~7 and comparative example 1~3 is taken, before use, according to the volume of drug and water
Than the ratio for 1:1000, said medicine is configured to dip to be used respectively.
Testing program: foot rot milk cow will be suffered from and be randomly divided into 10 groups, every group 45, amount to 450.Every group before lavipeditum
Spot and excrement cleaning are carried out to hoof, after cleaning up, carry out lavipeditum according to the dip provided in test grouping respectively, often
It is carried out lavipeditum 1 time, for 1 week, observes hoof inflammatory conditions.According to hoof health condition, be divided into health (suffer from hoof without flush or
Swelling, wound healing are walked lamely without obvious) or infection (clinical manifestation for having the foot rots such as ulcer, erosion, pain), efficient=
Healthy head number/test head number.
1 foot rot infected cattle dipping treatment condition of table
| Group | Test head number | Responding time | Cure time | Healthy head number | Infect head number | It is efficient |
| Comparative example 1 | 45 | 2 days | 6 days | 35 | 10 | 77.7% |
| Comparative example 2 | 45 | 3 days | 7 days | 34 | 11 | 75.5% |
| Comparative example 3 | 45 | 4 days | 7 days | 30 | 15 | 66.7% |
| Embodiment 1 | 45 | 2 days | 5 days | 44 | 1 | 97.8% |
| Embodiment 2 | 45 | 1 day | 5 days | 44 | 1 | 97.8% |
| Embodiment 3 | 45 | 1 day | 4 days | 45 | 0 | 100% |
| Embodiment 4 | 45 | 2 days | 5 days | 40 | 5 | 88.9% |
| Embodiment 5 | 45 | 2 days | 5 days | 43 | 2 | 95.6% |
| Embodiment 6 | 45 | 2 days | 6 days | 40 | 5 | 88.9% |
| Embodiment 7 | 45 | 2 days | 6 days | 41 | 4 | 91.1% |
| Embodiment 8 | 45 | 2 days | 6 days | 41 | 4 | 91.1% |
By the data of upper table 1 it is found that the effective percentage of comparative example 1~3 quite, effective percentage is below 77%, and embodiment 1~
8 effective percentage up to 88% or more, wherein the effective percentage of embodiment 1,2,3,5 is more than 95%, and drug effect is fast, with
The effective percentage that 1~3 group of comparative example has significant difference, and the effective percentage of embodiment 3 is even more to have reached 100%.These results suggest that
The drug of the embodiment of the present invention is very effective the prevention and treatment of milk cattle footrot.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of composition for preventing and treating animal foot rot, which is characterized in that the composition includes following effective component: penta 2
Aldehyde, quaternary ammonium salt and Thymol.
2. composition according to claim 1, which is characterized in that the quaternary ammonium salt is Deciquam.
3. composition according to claim 2, which is characterized in that the mass ratio of the glutaraldehyde and the Thymol is
(5~10): 1.
4. composition according to claim 3, which is characterized in that the glutaraldehyde and the mass ratio of the Deciquam are
1:(0.8~1.2).
5. a kind of drug for preventing and treating animal foot rot, which is characterized in that by mass percentage, be mainly prepared from the following raw materials:
2%~8% glutaraldehyde, 2%~8% quaternary ammonium salt, 0.1%~10% Thymol and 74%~95.5% solvent.
6. the drug of prevention and treatment animal foot rot according to claim 5, which is characterized in that by weight percentage, described
Prevention and treatment animal foot rot drug be mainly prepared from the following raw materials: 3%~6% glutaraldehyde, 3%~6% quaternary ammonium salt,
0.5%~5% Thymol and 83%~93.5% solvent.
7. the drug of prevention and treatment animal foot rot according to claim 5, which is characterized in that the solvent is selected from water, ethyl alcohol
One of with propylene glycol.
8. the drug of prevention and treatment animal foot rot according to claim 5, which is characterized in that the raw material of the drug further includes
Emollient.
9. the preparation method of the drug of the described in any item prevention and treatment animal foot rots of claim 5~8, which is characterized in that including
Following steps:
According to the raw material proportioning of the drug of the prevention and treatment animal foot rot, each component is uniformly mixed.
10. the preparation method of the drug of prevention and treatment animal foot rot according to claim 9, which is characterized in that further include making
The step of drug is diluted with water using liquid by the used time, the drug and the mass ratio for diluting water used be 1:(100~
5000)。
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| CN110637813A (en) * | 2019-08-30 | 2020-01-03 | 江西正邦动物保健品有限公司 | Aldehyde disinfectant |
| CN111066781A (en) * | 2019-12-31 | 2020-04-28 | 内蒙古益合技术服务有限公司 | Carvacoline disinfectant suitable for low-temperature use |
| CN112438969A (en) * | 2019-09-05 | 2021-03-05 | 河北地邦动物保健科技有限公司 | Pharmaceutical composition containing benzalkonium chloride, preparation method and application thereof |
| CN115300538A (en) * | 2022-08-30 | 2022-11-08 | 天津市一丰生物科技有限公司 | Composite cow hoof bath lotion and application thereof |
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Application publication date: 20190118 |