CN107049868A - A kind of pet detergent with sterilizing and preparation method thereof - Google Patents
A kind of pet detergent with sterilizing and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
Abstract
The invention discloses a kind of pet detergent with sterilizing, the detergent is made up of the raw material including following parts by weight：15 parts of sodium sulfate of polyethenoxy ether of fatty alcohol, 59 parts of APG, 15 parts of α sodium olefin sulfonates, 0.8 part of sodium hydroxide, 15 parts of antimicrobial component, 59.2 parts of water；And there is provided its preparation method.The pet is made with detergent with sterilizing by natural antibacterial ingredient with detergent ingredients, has sterilization and the effect of cleaning Pet fur concurrently, and antimicrobial component therein is formed by natural plants and its extract compounding.The detergent smell is gentle, it is small to pet and people's excitant, it can substantially reduce in Pet fur and take bacterium amount, ensure pet health, prevention disease occurs, and to dermatitis caused by infection, phlegm is itched, pathologic is lost hair or feathers etc., and disease has therapeutic action, overcome existing shampoo class bath article and only have abstersive defect.
Description
Technical field
The invention belongs to veterinary drug technical field, specifically, being related to a kind of pet detergent with sterilizing and preparation method thereof.
Background technology
With the raising of city life level, housing condition constantly improves, and what family population was constituted is continually changing, and raises
Cat, dog class pet family it is more and more, the life of pet and people are increasingly close, and its health status is also increasingly subject to raising pets
Main attention.The pet diseases such as dermatitis, sufferings, pathologic depilation annoying raising pets master.Pet fur is infected with carrying
Various pathogens more directly threaten the health of raising pets master.
Detergent and disinfectant are indispensable commodity in raising pets, carry the clean and tidy health of holding environment and people and
The great responsibility of animal health safety.With stepping up for people's health consciousness, detergent, disinfectant to pet it is also proposed that
New requirement.At present, it is fewer dedicated for the detergent of pet, disinfectant, and it is primarily present following defect：1st, product
Function is single, it is impossible to meet the dual needs of washing and sterilization；2nd, synthesis class, plant source series bactericidal agent are unable to expliciting the position, make
With unreasonable.For above-mentioned deficiency, the present invention is according to the characteristics of the market demand and use environment, design studies antibacterial, suppression
Bacterium detergent.
The content of the invention
First purpose of the present invention is that there is provided a kind of pet detergent with sterilizing, the sterilization in order to solve the above problems
Antimicrobial component in detergent is chosen from natural plants, is formed with detergent compounding, with sterilizing and nursing Animal Skin
The effect of hair.
Second object of the present invention is to provide the preparation method of above-mentioned detergent.
A kind of pet detergent with sterilizing, the detergent is made up of the raw material including following parts by weight：
Sodium sulfate of polyethenoxy ether of fatty alcohol（AES）15 parts, APG（APG）5-9 parts, α-sodium olefin sulfonate（AOS）1-5
Part, 0.8 part of sodium hydroxide, 15 parts of antimicrobial component, 59.2 parts of water.
As preferred, the detergent is made up of the raw material of following parts by weight：
Sodium sulfate of polyethenoxy ether of fatty alcohol（AES）15 parts, APG（APG）8 parts, α-sodium olefin sulfonate（AOS）2 parts, hydrogen
0.8 part of sodium oxide molybdena, 15 parts of antimicrobial component, 59.2 parts of water.
Further, the antimicrobial component is made up of the raw material of following parts by weight：
Touch fragrant volatile oil 1-10 parts, 1-10 parts of Salvia root P.E, 1-10 parts of Sophora alopecuroide alkali, 1-10 parts of abrine, 90% ethanol 5
Part.
As preferred, the antimicrobial component is made up of the raw material of following parts by weight：
Touch fragrant 2 parts of volatile oil, 3 parts of Salvia root P.E, 3 parts of Sophora alopecuroide alkali, 2 parts of abrine, 5 parts of 90% ethanol.
The preparation method of above-mentioned pet detergent with sterilizing, comprises the following steps：
（1）Using steam extraction method to drying after the fragrant aerial part that touches extract, collect distillate, distillate through extraction
Take and drying process, fragrant volatile oil must be touched；
（2）By step（1）The obtained fragrant volatile oil that touches is added in 90% ethanol with Salvia root P.E, Sophora alopecuroide alkali, abrine,
Heating stirring dissolves it, cooling, obtains antimicrobial component；
（3）By sodium sulfate of polyethenoxy ether of fatty alcohol（AES）In the water for adding 45 DEG C, constant temperature is stirred to dissolving, then adds alkane
Base glucosides（APG）, α-sodium olefin sulfonate（AOS）, sodium hydroxide and step（2）Obtained antimicrobial component, stirring is complete to dissolving,
Produce pet detergent with sterilizing.
Further, the step（1）In, the steam extraction time is 4h, and extractant selects petroleum ether, drying process
Drier is used as from anhydrous sodium sulfate.
Further, the step（2）In, heating-up temperature is 35-37 DEG C.
Application of the above-mentioned pet with detergent with sterilizing on pet cleaning.
Strict demand of the pet Special sterilizing detergent to people and animal body security, bactericide is suitably from natural plants
Choose.Need to meet following condition applied to the botanical fungicide in pet Special sterilizing detergent：First, water,
Favorable solubility in surfactant, will not produce precipitation or be layered；Secondly, smell is gentle, can not be on fur surface after washing
On leave penetrating odor, thus the bactericide of allicin, Chinese cassia tree aldehydes do not apply to；Then, ph stability is good, suitable
In addition, antibacterial requirement is met.In view of the antimicrobial component in conditions above, pet detergent with sterilizing of the invention is by touching
Fragrant volatile oil, Salvia root P.E, Sophora alopecuroide alkali and abrine compounding are formed.
It is MangNiu Er seedlings section storksbill to touch fragrant, and original producton location is heat-resisting in Europe and Southwest Asia, can not resist cold,
Sunlight is liked, the laudatory title of perfume, its smell such as peppermint, and slightly apple are touched because being enjoyed the fragrance of comfortable can be given out after touching
Fruit local flavor, with refreshing the mind, clearing away summerheat, mosquito repellent, effect of anti-inflammation detumescence and skin care.Touch fragrant volatile oil its
Main component is monoterpenes compound, and percentage contents account for the 92% of total volatile oil, and touching fragrant volatile oil has very strong antibacterial
With bactericidal action, and volatilization oil concentration it is bigger, bacteriostasis is stronger.
Main antipathogenic composition in Salvia root P.E is Cryptotanshinone, dihydrotanshinone, to external staphylococcus, large intestine
Bacillus, denaturation bacillus have inhibitory action.
Sophora alopecuroide alkali is primarily present in Sophora alopecuroide plant, has broad spectrum antibacterial.
Abrine is primarily present in sainfoin, there is certain antibacterial action.
Pet special purpose detergent is mainly in the cleaning of animal, according to the characteristic of the fur of animal, it is necessary to which detergent has
There is a good compatibility, it is nonirritant etc..Further, since the particularity that animals and human beingses are directly contacted, therefore pet is special antibacterial
Detergent must possess good to human body and the security of animal.Detergent in the pet Special sterilizing detergent of the present invention
From sodium sulfate of polyethenoxy ether of fatty alcohol（AES）, APG（APG）, α-sodium olefin sulfonate（AOS）And sodium hydroxide.
Sodium sulfate of polyethenoxy ether of fatty alcohol（AES）For anion surfactant, from the point of view of washing functions, not only go
Dirty, emulsification, foam performance are excellent, it is often more important that with hard water resistance performance.In addition, can also be with other a variety of surfactants
Compounding use is carried out, so as to improve detergency.In terms of safety and environmental protection, AES properties are gentle, not injured skin, biology drop
Solution degree 99%, is the surfactant of environmental type.
APG（APG）For nonionic surfactant, the good emulsification of tool and foam performance.On the one hand, compatibility
It is good, after AES compoundings, synergy is produced, clean effect can be significantly improved.On the other hand, there is good phase with plastic products
Capacitive, will not cause the cracking of plastic products after washing.In addition, APG is low to skin irritation, nontoxic.
α-sodium olefin sulfonate（AOS）Belong to anion surfactant, its mildness is very good, close to non-ionic surface
Activating agent, has good compatibility, especially with AES with excellent foaming characteristic, foam stability, and with other surfaces activating agent
There is synergy under certain proportion, clean effect is good.In addition, AOS properties are gentle, easily biological-degradable, the feature of environmental protection is good, also has
There are the low advantage of cryogenic conditions lower critical micellar concentration and excellent resistance to hard water.
Beneficial effects of the present invention are：
The pet detergent with sterilizing that the present invention is provided, is made by natural antibacterial ingredient with detergent ingredients, has sterilization concurrently and clear
The effect of clean Pet fur, antimicrobial component therein is formed by natural plants and its extract compounding.The detergent smell is gentle,
It is small to pet and people's excitant, the bacterium amount of taking in Pet fur can be substantially reduced, pet health is ensured, prevention disease occurs, and
To dermatitis caused by infection, phlegm is itched, pathologic is lost hair or feathers etc., and disease has therapeutic action, overcomes existing shampoo class bath article and only has
Abstersive defect.
Embodiment
The preferred embodiments of the present invention are illustrated below, it will be appreciated that preferred embodiment described herein is only used
In the description and interpretation present invention, it is not intended to limit the present invention.
Embodiment 1
The preparation method of antimicrobial component
（1）Crushed after the fresh aerial part for touching perfume is dried, weigh 100g coarse powder, with steam distillation, extract it and wave
Hair oil, distillation time 4h, distillate obtains light yellow liquid with petroleum ether extraction, and fragrant volatilization must be touched with anhydrous sodium sulfate drying
Preserved in oil, refrigerator, it is standby.
（2）The material of difference precise following weight parts：Touch fragrant volatile oil 1-10 parts, 1-10 parts of the red sage root, Sophora alopecuroide
1-10 parts of alkali, 1-10 parts of abrine.
（3）It each material will add above in 5 parts of 90% ethanol, and be heated to 35-37 DEG C, stirring makes it fully dissolve, cool,
Obtain antimicrobial component.
Embodiment 2
The preparation method of pet detergent with sterilizing
In parts by weight, by sodium sulfate of polyethenoxy ether of fatty alcohol（AES）15 parts add in 45 DEG C of 59.2 parts of deionized waters, constant temperature
Then stirring adds APG to dissolving（APG）5-9 parts, α-sodium olefin sulfonate（AOS）1-5 parts, 0.8 part of sodium hydroxide and
15 parts of the antimicrobial component of embodiment 1, stirring is complete to dissolving, and produces pet detergent with sterilizing.
Screening, the detergency test of pet detergent with sterilizing and the disinfection effect test of antimicrobial component are carried out below.
First, the screening of antimicrobial formulation
The single fragrant volatile oil that touches just has stronger anti-rejection ability to Escherichia coli and staphylococcus aureus.And the red sage root,
The bacteriostasis of the plant extracts such as Sophora alopecuroide, sainfoin is weaker, therefore, in use, it is necessary to be compounded.Salvia root P.E
With the appropriate mass ratio of Sophora alopecuroide alkali, there is collaboration bacteriostasis to Escherichia coli and staphylococcus aureus；Equally, the red sage root is carried
The appropriate mass ratio of thing and abrine is taken, there is collaboration bacteriostasis to Escherichia coli and staphylococcus aureus；Abrine with
Escherichia coli and staphylococcus aureus are had collaboration bacteriostasis by the appropriate mass ratio of Sophora alopecuroide alkali.
1.1 test material
Test plant：Touch fragrant purchased from Lanzhou City, Gansu Province flowers market；
Salvia root P.E（Cryptotanshinone 3%）：Xi'an Qing Ping plant extracts Co., Ltd；
Sophora alopecuroide alkali（Total alkali 65%）：Yanchi County, ningxia is all along biochemical industry Co., Ltd；
Abrine（Total alkali 60%）：Hubei Xin Kang medication chemistries Co., Ltd；
For examination strain：Escherichia coli ATCC25922, staphylococcus aureus ATCC25923, purchased from China Veterinary Drugs Supervisory Inst..
1.2 touch the preparation of fragrant volatile oil
Crushed after the fresh aerial part for touching perfume is dried, weigh 100g coarse powder, with steam distillation, extract its volatilization
Oil, distillation time 4h, distillate obtains light yellow liquid with petroleum ether extraction, and fragrant volatile oil must be touched with anhydrous sodium sulfate drying,
Preserved in refrigerator, it is standby.
The preparation of 1.3 bacteria suspensions
LB fluid nutrient mediums will be inoculated with, 37 DEG C of isothermal vibration 24h of shaking table are supplied for examination strain LB slant mediums activation
Bacterium solution is tried, is made with sterile saline containing 106-107cfu.ml-1The bacteria suspension of individual bacterium.
The measure of 1.4 fungistatic effects
Fragrant volatile oil, which will be touched, with the sterilized water containing 5% Tween-80 is diluted to 100,50,10,5,2.5 and 1.25mg.ml respectively-1, the 55 DEG C of LB solid mediums of fragrant volatile oil and 9ml that touch after 1ml dilutions are then separately added into each culture dish and are mixed,
It is made successively containing 10,5,1,0.5,0.25 and 0.125mg.ml-1The plating medium of fragrant volatile oil is touched, plating medium is treated
10 μ l are taken to contain 10 after solidification6-107cfu.ml-1The bacteria suspension of individual bacterium is coated on plating medium surface, and 3 are repeated per concentration
It is secondary.To connect the non-volatile oily LB solid mediums of bacteria suspension as positive control, with LB solid culture of the sterile suspension containing volatile matter
Base is negative control.It is placed in observe after 37 DEG C of incubated 24h and counts, evaluates its fungistatic effect.
Fragrant volatile oil, Salvia root P.E, Sophora alopecuroide alkali, abrine and its complex are touched with same concentrations antipathogenic composition
Bacteriostatic experiment is carried out for examination bacterium to 2 kinds, method is ibid.Antipathogenic composition concentration and fungistatic effect are shown in Table 1 in culture medium.
Antipathogenic composition constituent concentration and fungistatic effect in the culture medium of table 1
As shown in Table 1, fragrant volatile oil is touched preferable to the fungistatic effect of staphylococcus aureus and Escherichia coli with Sophora alopecuroide alkali.
After compound, No. 6 antiseptic effects are greatly improved, and illustrate there is preferable coordinative role, and the proportioning of No. 6 samples is set into antibacterial
The optimum proportioning of composition.
2nd, the stability and detergency test of pet detergent with sterilizing
The preparation of 2.1 pet detergent with sterilizing
Antimicrobial component is prepared as described in Example 1, and it matches the proportioning according to No. 6 antimicrobial components.Make as described in Example 2
Standby pet detergent with sterilizing, each raw material weight proportioning of soup processed is shown in Table 2.
The pet detergent with sterilizing raw material proportioning of table 2
The outward appearance and stability test of 2.2 pet detergent with sterilizing
No. 5 products of 1- are clear, yellow solution in table 2, tasteless.It is positioned in -5 DEG C of environment after 24h, takes out,
Putting makes it slowly recover to room temperature under room temperature condition, do not crystallize and precipitate generation；It is placed in（40±1）DEG C insulating box in
24h, taking-up is observed immediately, is not layered and muddy generation, and smell does not also change, qualified stability.
The detergency test of 2.3 pet detergent with sterilizing
Method of testing：It is one group to take 6 slides, quality M0 before weighing is defiled, and greasy dirt then is smeared into equal in slide one side
It is even, the M1 that weighed after 4h is dried, it is 0.65g ± 0.05g to control the every group of amount of defiling.Washing survey is carried out with sample 1-5 detergent
Examination, after washing and drying, weighs its mass M 2.
Oil cut rate is gone in calculating, and each sample repeats experiment 3 times, averages, the % of control relative average debiation≤5.Go oil cut rate
Formula is shown in calculating.
Remove oil cut rate=(M1-M2)/(M1-M0) %
According to detergency test is carried out to sample 1-5, each sample retest three times goes oil cut rate to take three results to be averaged
Value, and relative average debiation is calculated, it the results are shown in Table 3.
The each group detergency test data of table 3
As shown in table 3, the equal ＜ 5% of the relative average debiation of each group detergency test data, illustrates that detergency test data are reliable,
Wherein No. 2 detergency best results, under equal conditions, it is 97.8% to measure oil cut rate.
3rd, No. 2 pet detergent with sterilizing disinfecting effect observings
3.1 test material
For examination strain：Using ATCC6538 plants of sterilizing test representative strain staphylococcus aureus, ATCC8099 plants of Escherichia coli,
ATCC10231 plants of Candida albicans.
Disinfectant：No. 2 detergent with sterilizing of above-mentioned preparation.
Nertralizer：The compound nertralizer being made into 3.0% Tween-80,0.3% lecithin is used, preceding neutralized experiment is used
Prove its neutralization.
3.2 test method
3.2.1 neutralization test
Using chemical neutralisation, neutralizer is the compound nertralizer containing 3.0% Tween-80,0.3% lecithin.Test strain is gold
TCC6538 plants of staphylococcus aureus.Press《Sterilization and sterilizing experimental technique specification》Regulation, neutralization test is divided into 8 groups：1. disinfectant
+ experiment bacteria suspension → culture；2. (disinfectant+bacteria suspension)+nertralizer → culture；3. nertralizer+bacteria suspension → culture；4. (disappear
Toxic agent+nertralizer)+bacteria suspension → culture；5. PBS+ bacteria suspensions → culture；6. to testing with same batch PBS → culture；7. test
With same batch nertralizer → culture；8. test with same batch cultivation base → culture.
3.2.2 laboratory quantitative disinfecting test
Using Suspension quantitative bactericidal test.It is 5 × 10 to prepare bacteria containing amount5-5×106Cfu/ml bacteria suspensions are used to test.Will sterilization
Agent 5.0ml is placed in test tube, puts 20 DEG C of water-baths 5 minutes, plus people 0.1ml bacteria suspensions are mixed, and acts on 0.5 respectively, 1,2,5,10 points
Kind, draw this mixed liquor 0.5ml and be added on mixing in 1.5ml nertralizer test tubes, after acting on 10 minutes respectively, take 0.5ml to use respectively
Tilt-pour process does count plate.Test sample puts culture 48 hours in 37 DEG C of incubators, observes final result.
3.2.3 organic substance influence is tested
Bacteria suspension added with the staphylococcus aureus of 1% albumen is made into containing 50% and 25% calf serum Staphylococcus aureus
Bacterium bacteria suspension, does Suspension quantitative bactericidal test, and with not adding the bacteria suspension of calf serum to be compared, method is ibid.
3.2.4 field test
New zealand white rabbit 30 is taken, 5 × 5cm squares, respectively test group and control group are marked in its ridge portion adjacent regions,
The control group rabbit hair is cut during experiment, put in people's nertralizer containing 10ml test tube, test group spray disinfectant 3ml is combed with wooden comb, made
Be distributed in surface, the rabbit hair is cut after 10 minutes, put in people's nertralizer containing 10ml test tube neutralize 10 minutes after, rapping is uniform
Analysis, its result is observed after 48 hours.
3.2.5 stability test
Using accelerated test, disinfectant is placed in 54 DEG C of water-baths 14 days, determining it before placing and after placing reads white
The killing action that ATCC10231 plants of pearl bacterium.
3.3 result of the test
3.3.1 neutralization test result
Neutralization test the results are shown in Table 4.
The disinfectant neutralization test result of table 4
With ATCC6538 plants of staphylococcus aureus for indicator bacteria.As shown in Table 4, nertralizer used can neutralize No. 2 completely and disappear
The bactericidal action of toxic agent, neutralized reaction product is had no significant effect to experiment microorganism, and explanation can be carried out disinfection experiment with this nertralizer.
3.3.2 laboratory quantitative disinfecting test result
Sterilization test the results are shown in Table 5.
The disinfectant sterilization test result of table 5
As shown in Table 5, act on 2 minutes can be by ATCC10231 plant killings of Candida albicans up to 100% for No. 2 disinfectants；Effect 1 minute
ATCC8099 plants of ATCC6538 plants of staphylococcus aureus and Escherichia coli can be killed up to 99.99% respectively with 2 minutes.
3.3.3 organic substance influence result of the test
Staphylococcus aureus bacteria suspension containing 25%, 50% calf serum and without calf serum is acted on 5 minutes, and killing rate reaches
To more than 99.90%.Disinfectant is to the killing effect of staphylococcus aureus protected with 25%, 50% calf serum without obvious shadow
Ring.
3.2.4 site test results
It is sprayed on rabbit back test group region with disinfectant 3ml, and is combed with wooden comb uniform, will can be carried in the rabbit hair within 10 minutes
Natural bacteria is averagely killed up to 90.50%.
3.2.5 stability test result
Disinfectant is shown in Table 6 to the killing action of ATCC10231 plants of Candida albicans before placing and after placing.
The disinfectant of table 6 places the front and rear killing effect to Candida albicans
As shown in Table 6, the killing rate of disinfectant is without obvious reduction before and after placing, and disinfectant is to Candida albicans before and after placing
ATCC10231 plants of killing rates reach that 99.9% time is 5 minutes.Effective storage period of the disinfectant can be 1 year.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, although with reference to foregoing reality
Apply example the present invention is described in detail, for those skilled in the art, it still can be to foregoing each implementation
Technical scheme described in example is modified, or carries out equivalent substitution to which part technical characteristic.All essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (8)
1. a kind of pet detergent with sterilizing, it is characterised in that the detergent is made up of the raw material including following parts by weight：
15 parts of sodium sulfate of polyethenoxy ether of fatty alcohol, 5-9 parts of APG, α -1-5 parts of sodium olefin sulfonate, 0.8 part of sodium hydroxide,
15 parts of antimicrobial component, 59.2 parts of water.
2. pet detergent with sterilizing according to claim 1, it is characterised in that the detergent is by following parts by weight
Raw material is made：
15 parts of sodium sulfate of polyethenoxy ether of fatty alcohol, 8 parts of APG, 2 parts of α-sodium olefin sulfonate, 0.8 part of sodium hydroxide, antibacterial
15 parts of composition, 59.2 parts of water.
3. pet detergent with sterilizing according to claim 1 or 2, it is characterised in that the antimicrobial component by weighing as follows
The raw material of amount part is made：
Touch fragrant volatile oil 1-10 parts, 1-10 parts of Salvia root P.E, 1-10 parts of Sophora alopecuroide alkali, 1-10 parts of abrine, 90% ethanol 5
Part.
4. pet detergent with sterilizing according to claim 3, it is characterised in that the antimicrobial component is by following parts by weight
Raw material be made：
Touch fragrant 2 parts of volatile oil, 3 parts of Salvia root P.E, 3 parts of Sophora alopecuroide alkali, 2 parts of abrine, 5 parts of 90% ethanol.
5. the preparation method of the pet detergent with sterilizing described in claim any one of 1-4, it is characterised in that including following step
Suddenly：
（1）Using steam extraction method to drying after the fragrant aerial part that touches extract, collect distillate, distillate through extraction
Take and drying process, fragrant volatile oil must be touched；
（2）By step（1）The obtained fragrant volatile oil that touches is added in 90% ethanol with Salvia root P.E, Sophora alopecuroide alkali, abrine,
Heating stirring dissolves it, cooling, obtains antimicrobial component；
（3）In the water that sodium sulfate of polyethenoxy ether of fatty alcohol is added to 45 DEG C, constant temperature is stirred to dissolving, then adds alkyl sugar
Glycosides, α-sodium olefin sulfonate, sodium hydroxide and step（2）Obtained antimicrobial component, stirring is complete to dissolving, and produces pet sterilization
Detergent.
6. the preparation method of pet detergent with sterilizing according to claim 5, it is characterised in that the step（1）In,
The steam extraction time is 4h, and extractant selects petroleum ether, and drying process is used as drier from anhydrous sodium sulfate.
7. the preparation method of pet detergent with sterilizing according to claim 5, it is characterised in that the step（2）In,
Heating-up temperature is 35-37 DEG C.
8. application of the pet described in claim any one of 1-4 with detergent with sterilizing on pet cleaning.
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| CN107049868B (en) | 2020-06-05 |
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