CN106176362A - A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation method thereof - Google Patents
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation method thereof Download PDFInfo
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- CN106176362A CN106176362A CN201610595254.1A CN201610595254A CN106176362A CN 106176362 A CN106176362 A CN 106176362A CN 201610595254 A CN201610595254 A CN 201610595254A CN 106176362 A CN106176362 A CN 106176362A
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- sophorae alopecuroidis
- herba sophorae
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- hand cleanser
- antibiotic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention provides a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, component including following parts by weight: Herba Sophorae alopecuroidis extract 15 parts, 11 41 parts of surfactant, diminishing moisture-retaining 4 14 parts, fatting agent 13 parts, chelating agen 0.2 1 parts, thickening agent 39 parts, preservative 0.03 0.2 parts, wherein, containing the total alkaloid of sophora alopecuroide that mass fraction is 30% 65% in Herba Sophorae alopecuroidis extract.In the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that the present invention provides, clean effect is good, antibacterial effect obvious, skin moistening skin care effect is notable, non-stimulated to skin safe.Present invention also offers the preparation method of a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, comprise the following steps: distilled water is heated to 50 60 DEG C, it is sequentially added into surfactant, diminishing moisture-retaining, fatting agent, chelating agen and thickening agent, it is stirred continuously uniformly, then Herba Sophorae alopecuroidis extract and preservative it are sequentially added into, continue to stir, obtain Herba Sophorae alopecuroidis antibiotic skincare hand cleanser.The preparation method of the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that the present invention provides is simple, has a extensive future.
Description
Technical field
The present invention relates to daily-use chemical industry technical field, be specifically related to a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation side thereof
Method.
Background technology
Hand is easiest to touch the pathogenic microorganisms such as various antibacterial, virus.Numerous studies show, wash one's hands and can effectively eliminate
The generation of multiple infectious disease, and stop it to propagate, by internationally recognized for being prevention, control disease propagation and propagate to have most
Effect, the simplest and most economical method.Handwashing liquid is a kind of hand cleaning product in recent years occurring and coming into vogue.With traditional
Soap is compared, easy to use, and cleaning performance is more preferable, has moist nursing role to hand simultaneously, many use pump head nozzles, it is to avoid
Bar soap becomes easily infected by the defect of dirt on hand and antibacterial, decreases the probability of cross infection, therefore deep by consumer
Like, be widely used in the public places such as family, restaurant, restaurant, station and hospital.Current handwashing liquid disinfecting, antimicrobial is adopted mostly
Limit the chemical compositions such as the triclosan of use, hibitane with country, bactericidal effect is general；And easily occur after using being dried feelings
Condition, life-time service is unfavorable to health.
, life-time service big for the composition zest of disinfection in solution handwashing liquid causes pachylosis, dry and cracked and decortication
Problem, mechanism is developing skin-care disinfecting and sterilizing hand sanitizer in a organized way.In recent years, gentle with it, non-stimulated, have and kill
Bacterium, bacteriostasis efficacy and degradable natural extract (such as Flos Jasmini Nudiflori extract, Flos Lonicerae, Chinese herbal medicine extract etc.) part or complete
Portion substitutes the chemical antimicrobial component in handwashing liquid, is just paid close attention to by people.
Herba Sophorae alopecuroidis (Sophora alopecuroides L.) is pulse family (Leguminosae) sophora plant, containing bitter bean
Sub-alkaloid and the main chemical compositions such as flavone, volatile oil, the alkaloid tool during research shows the extract of Herba Sophorae alopecuroidis both at home and abroad
There are the multiple biological activitys such as anti-inflammation, antiviral, parasite killing, antitumor.The research of Shi Quanren etc. (Shi Quanren etc., 2003) shows
Herba Sophorae alopecuroidis alkali disinfectant solution is to escherichia coli, Candida albicans, staphylococcus aureus, the average kill ratio of Diplococcus gonorrhoeae
Reaching more than 99.90%, its stock solution is to chmice acute oral toxicity LD (50) > 5000mg/kg, and vagina mucocutaneous to rabbit glues
Film nonirritant, has certain killing effect to bacterial propagule, and safety in utilization is relatively good.At present, Herba Sophorae alopecuroidis is utilized to extract
The anti-inflammation activity of thing has been developed for the products such as disinfectant solution, but not yet has hand cleanser products based on Herba Sophorae alopecuroidis extract to be seen in
Report.
Summary of the invention
For solving the problems referred to above, the invention provides a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser and preparation method thereof.This
The Herba Sophorae alopecuroidis antibiotic skincare hand cleanser cleaning effect of bright offer is good, has obvious antibiotic and sterilizing effect and skin protection skin moistening merit simultaneously
Energy.
First aspect present invention provides a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, including the component of following parts by weight:
Wherein, containing mass fraction in described Herba Sophorae alopecuroidis extract is the total alkaloid of sophora alopecuroide of 30%-65%.
Wherein, described surfactant includes anion surfactant, nonionic surfactant and amphion table
At least one in the activating agent of face.
Wherein, described surfactant is described anion surfactant, described nonionic surfactant and described
The mixture that zwitterionic surfactant is formed.
Wherein, described anion surfactant is polyoxyethylenated alcohol sodium sulfate and sodium lauryl sulphate, institute
Stating nonionic surfactant is coconut oil diethanol amide, and described zwitterionic surfactant is that Oleum Cocois amido propyl is sweet
Dish alkali, described polyoxyethylenated alcohol sodium sulfate, described sodium lauryl sulphate, described coconut oil diethanol amide and described
The weight ratio of cocoamidopropyl betaine is 3-15:3-10:2-6:3-10.
Wherein, described Herba Sophorae alopecuroidis antibiotic skincare hand cleanser includes the component of following parts by weight: Herba Sophorae alopecuroidis extract 3 parts,
Polyoxyethylenated alcohol sodium sulfate 10 parts, sodium lauryl sulphate 4 parts, coconut oil diethanol amide 4 parts, Oleum Cocois amide third
Base glycine betaine 5 parts, diminishing moisture-retaining 9 parts, fatting agent 2 parts, chelating agen 0.5 part, thickening agent 4 parts, preservative 0.1 part.
Wherein, at least one during described diminishing moisture-retaining includes glycerol and propylene glycol.
Wherein, described fatting agent is isopropyl myristate, monoglyceride, glyceryl cocoate, the poly-second of glycerol cocoyl
At least one in diol ester, octyl group hydroxy stearic acid ester, glycerol and pantothenylol.
Wherein, described preservative is Kazon, sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, Ni Bo
At least one in gold butyl ester and methylchloroisothiazandnone.
Each component compatibility in the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that first aspect present invention provides is reasonable, is a kind of cleaning
Clean effect is good, antibacterial effect is obvious, skin moistening skin care effect notable, the handwashing liquid non-stimulated to skin safe.
Second aspect present invention provides the preparation method of a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, comprises the following steps:
Distilled water is heated to 50-60 DEG C, is sequentially added into surfactant, diminishing moisture-retaining, fatting agent, chelating agen and increasing
Thick dose, it is stirred continuously to being uniformly dissolved, is then sequentially added into Herba Sophorae alopecuroidis extract and preservative, continue to stir, obtain hardship
Bean or pea antibiotic skincare hand cleanser.
Wherein, the preparation method of described Herba Sophorae alopecuroidis extract is: after herba Sophora alopecuroide or sophora alopecuroide being pulverized, add ethanol
Aqueous solution or deionized water extraction 2-4 time, the temperature every time extracted is 60-80 DEG C, and the time every time extracted is 0.5-2h, then
Filter, by filtrate reduced in volume, obtain described Herba Sophorae alopecuroidis extract after drying.
The preparation method of the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that second aspect present invention provides is simple, is suitable for industry metaplasia
Produce, have a extensive future.
To sum up, beneficial effect of the present invention includes the following aspects:
1, each component compatibility in the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that the present invention provides is reasonable, and bacteriostasis and sterilization effect is bright
Aobvious, clean result is good, little to the zest of skin, and has broad-spectrum antibacterial effect, and has no side effect, and is that one has
Dirty, sterilize the antibacterial and handwashing liquid of skin protection multi-efficiency；
2, the preparation method of the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that second aspect present invention provides is simple, is suitable for industry metaplasia
Produce, have a extensive future.
Detailed description of the invention
The following stated is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications are also considered as
Protection scope of the present invention.
First aspect present invention provides a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, including the component of following parts by weight:
Wherein, containing mass fraction in Herba Sophorae alopecuroidis extract is the total alkaloid of sophora alopecuroide of 30%-65%.
In an embodiment of the present invention, Herba Sophorae alopecuroidis extract is the flavone of 10% possibly together with mass fraction.Flavone also has
There is certain antibacterial action.
In an embodiment of the present invention, the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that the present invention provides, with the addition of Herba Sophorae alopecuroidis and extract
Thing, makes handwashing liquid have obvious antibiotic and sterilizing anti-inflammatory effect, and simultaneously non-stimulated to skin, safety is higher.
In an embodiment of the present invention, total alkaloid of sophora alopecuroide include sophoridine, matrine, oxymatrine, aloperine,
The various of monomer alkali such as sophocarpine, Oxysophoridine, eulexine, N-Methylcytisine, anagyrine.
In an embodiment of the present invention, surfactant include anion surfactant, nonionic surfactant and
At least one in zwitterionic surfactant.
In the present invention one preferred implementation, surfactant is anion surfactant, nonionic surfactant
The mixture formed with zwitterionic surfactant.
In the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that the present invention provides, surfactant is the active substance of handwashing liquid, and it is main
Wanting function is to remove grease on hand and dirt, and produces certain foam.In this handwashing liquid, foam power relatively strong with detergency
The anion surfactant good with foam stability is as primary surfactant, in order to clean greasy dirt rapidly and thoroughly.This
Bright with nonionic surfactant, zwitterionic surfactant as cosurfactant, they are equal with primary surfactant
There is the good compatibility compatibility, have good metal ion acidproof, alkaline-resisting, resistance to, resistance to hard water ability, decontamination, bubbling ability to fit
In, little to skin irritation.Therefore, in this handwashing liquid, using anion surfactant as primary surfactant, with nonionic
Surfactant, zwitterionic surfactant are cosurfactant, utilize cooperative effect to improve surface activity, decontamination
Property, improve the compatibility of its dissolubility, stability and skin simultaneously.
In an embodiment of the present invention, anion surfactant is polyoxyethylenated alcohol sodium sulfate and dodecyl
Sodium sulfate, nonionic surfactant is coconut oil diethanol amide, and zwitterionic surfactant is Oleum Cocois amido propyl
Glycine betaine, polyoxyethylenated alcohol sodium sulfate, sodium lauryl sulphate, coconut oil diethanol amide and Oleum Cocois amido propyl
The weight ratio of glycine betaine is 3-15:3-10:2-6:3-10.
The present invention is with anion surfactant polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate
(K12) it is primary surfactant, with nonionic surfactant coconut oil diethanol amide (6501), amphion surface activity
Agent cocoamidopropyl betaine (CAB) is cosurfactant, and the surfactant obtained is complexed surfactant,
These several surfactant compatibilities are reasonable, and dirt-removing power is strong, foaming abundancy, and little to skin irritation, and biological degradability is good.
In an embodiment of the present invention, diminishing moisture-retaining includes at least one in glycerol and propylene glycol.
In an embodiment of the present invention, diminishing moisture-retaining is the weight of the mixture of glycerol and propylene glycol, glycerol and propylene glycol
Amount ratio is 2-8:2-6.
In an embodiment of the present invention, fatting agent is isopropyl myristate, monoglyceride, glyceryl cocoate, glycerol
At least one in cocoyl macrogol ester, octyl group hydroxy stearic acid ester, glycerol and pantothenylol.
The handwashing liquid of the present invention with the addition of diminishing moisture-retaining and fatting agent and washes one's hands as skin moistening moisturizing ingredient, use handwashing liquid
Rear skinfeel is joyful, has skin protection skin moistening effect to skin, and after effectively preventing from washing one's hands, xerosis cutis, decortication phenomenon, be suitable for making for a long time
With.
In an embodiment of the present invention, chelating agen is disodiumedetate (EDTA).
In an embodiment of the present invention, thickening agent includes NaCl and carboxymethyl cellulose.
In the present invention one preferred implementation, the weight ratio of NaCl and carboxymethyl cellulose is 1-4:2-5.
In an embodiment of the present invention, preservative is Kazon, sodium benzoate, methyl hydroxybenzoate, ethyl hydroxybenzoate, nipalgin
At least one in propyl ester, butoben and methylchloroisothiazandnone.
In the present invention one preferred implementation, preservative is Kazon, and Kazon can reach good antiseptic effect.
Herba Sophorae alopecuroidis extract in Herba Sophorae alopecuroidis antibiotic skincare hand cleanser of the present invention jointly plays anticorrosion after mixing with preservative and resists
Bacterium effect, is possible to prevent and suppresses the growth of handwashing liquid antibacterial, and extend product deposits the time limit.
In an embodiment of the present invention, also including pH adjusting agent in Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, pH adjusting agent is lemon
Lemon acid.
The amount of pH adjusting agent is not done particular determination by the present invention, it is possible to by the pH regulator of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser be
Neutral.
In an embodiment of the present invention, the pH of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser is neutral.
In an embodiment of the present invention, Herba Sophorae alopecuroidis antibiotic skincare hand cleanser also includes outward appearance regulator.
In the present invention one preferred implementation, outward appearance regulator is essence, pigment and pearling agent.
In the present invention one preferred implementation, the amount of outward appearance regulator is not done particular determination by the present invention, in right amount.
In the present invention one preferred implementation, Herba Sophorae alopecuroidis antibiotic skincare hand cleanser of the present invention also includes distilled water, distillation
Water is appropriate.The present invention uses distilled water as solvent, and the amount that distilled water adds is that industry routine selects, and does not do special limit at this
Fixed.
In the present invention one preferred implementation, Herba Sophorae alopecuroidis antibiotic skincare hand cleanser includes the component of following parts by weight: bitter
Bean or pea extract 3 parts, polyoxyethylenated alcohol sodium sulfate 10 parts, sodium lauryl sulphate 4 parts, coconut oil diethanol amide 4
Part, cocoamidopropyl betaine 5 parts, diminishing moisture-retaining 9 parts, fatting agent 2 parts, chelating agen 0.5 part, thickening agent 4 parts, anticorrosion
Agent 0.1 part.
In the present invention one preferred implementation, the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser of 100 parts of weight portions includes following weight
The component of number: Herba Sophorae alopecuroidis extract 3 parts, polyoxyethylenated alcohol sodium sulfate (AES) 10 parts, sodium lauryl sulphate
(K12) 4 parts, coconut oil diethanol amide (6501) 4 parts, cocoamidopropyl betaine (CAB) 5 parts, glycerol 5 parts, the third two
Alcohol 4 parts, isopropyl myristate 2 parts, disodiumedetate (EDTA) 0.5 part, NaCl 1 part, carboxymethyl cellulose 3 parts,
Kazon 0.1 part, outward appearance regulator is appropriate, and citric acid adjusts pH to 7.0, adds distilled water and supplies 100 parts.
Each component compatibility in the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that first aspect present invention provides is reasonable, is a kind of cleaning
Clean effect is good, antibacterial effect is obvious, skin moistening skin care effect notable, the handwashing liquid non-stimulated to skin safe.
Second aspect present invention provides the preparation method of a kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, comprises the following steps:
Distilled water is heated to 50-60 DEG C, is sequentially added into surfactant, diminishing moisture-retaining, fatting agent, chelating agen and increasing
Thick dose, it is stirred continuously to being uniformly dissolved, is then sequentially added into Herba Sophorae alopecuroidis extract and preservative, continue to stir, obtain hardship
Bean or pea antibiotic skincare hand cleanser.
In an embodiment of the present invention, the preparation method of Herba Sophorae alopecuroidis extract is: herba Sophora alopecuroide or sophora alopecuroide are pulverized
After, adding ethanol water or deionized water extraction 2-4 time, the temperature every time extracted is 60-80 DEG C, and the time of extraction is every time
0.5-2h, then filters, and by filtrate reduced in volume, obtains Herba Sophorae alopecuroidis extract after drying.
In an embodiment of the present invention, the concentration of ethanol water is 50-80%.
In an embodiment of the present invention, after herba Sophora alopecuroide or sophora alopecuroide being pulverized, add herba Sophora alopecuroide or sophora alopecuroide
The ethanol water of 4-10 times of volume extracts 2-4 time.
In an embodiment of the present invention, Herba Sophorae alopecuroidis extract can also be from directly the most commercially, Herba Sophorae alopecuroidis extract
In containing mass fraction be the total alkaloid of sophora alopecuroide of 30%-65%.
The preparation method of Herba Sophorae alopecuroidis extract of the present invention is simple to operate, and cost is relatively low, environmentally safe.
The preparation method of the Herba Sophorae alopecuroidis antibiotic skincare hand cleanser that second aspect present invention provides is simple, is suitable for industry metaplasia
Produce, have a extensive future.
Embodiment 1:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: Herba Sophorae alopecuroidis extract 1 part, fat
10 parts of polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate (K12) 4 parts, coconut oil diethanol amide (6501) 4 parts,
Cocoamidopropyl betaine (CAB) 5 parts, glycerol 5 parts, propylene glycol 4 parts, isopropyl myristate 2 parts, ethylenediaminetetraacetic acid
Disodium (EDTA) 0.5 part, NaCl 1 part, carboxymethyl cellulose 3 parts, Kazon 0.1 part, the regulation of the outward appearance such as essence, pigment, pearling agent
Agent is appropriate, and citric acid adjusts pH to 7.0, adds distilled water and supplies 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows:
(1) take part distilled water and be heated to 55 DEG C, be sequentially added into polyoxyethylenated alcohol sodium sulfate according to formula
(AES), sodium lauryl sulphate (K12), coconut oil diethanol amide (6501), cocoamidopropyl betaine (CAB), sweet
Oil, propylene glycol, isopropyl myristate, disodiumedetate (EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to
All it is uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 7.0, adds surplus distilled water, continues to stir, and bottling gets product.
Wherein, the preparation method of Herba Sophorae alopecuroidis extract is: pulverized by herba Sophora alopecuroide, adds 60% ethanol of 8 times of volumes
Extraction with aqueous solution 3 times, each Extracting temperature is 80 DEG C, and extraction time is 1h, filters, and filtrate reduced in volume, obtains hardship after drying
Bean or pea extract.
Embodiment 2:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: Herba Sophorae alopecuroidis extract 3 parts, fat
10 parts of polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate (K12) 4 parts, coconut oil diethanol amide (6501) 4 parts,
Cocoamidopropyl betaine (CAB) 5 parts, glycerol 5 parts, propylene glycol 4 parts, isopropyl myristate 2 parts, ethylenediaminetetraacetic acid
Disodium (EDTA) 0.5 part, NaCl 1 part, carboxymethyl cellulose 3 parts, Kazon 0.1 part, the regulation of the outward appearance such as essence, pigment, pearling agent
Agent is appropriate, and citric acid adjusts pH to 7.0, adds distilled water and supplies 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows:
(1) take part distilled water and be heated to 55 DEG C, be sequentially added into polyoxyethylenated alcohol sodium sulfate according to formula
(AES), sodium lauryl sulphate (K12), coconut oil diethanol amide (6501), cocoamidopropyl betaine (CAB), sweet
Oil, propylene glycol, isopropyl myristate, disodiumedetate (EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to
All it is uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 7.0, adds surplus distilled water, continues to stir, and bottling gets product.
Wherein, the preparation method of Herba Sophorae alopecuroidis extract is: pulverized by herba Sophora alopecuroide, adds 60% ethanol of 8 times of volumes
Extraction with aqueous solution 3 times, each Extracting temperature is 80 DEG C, and extraction time is 1h, filters, and filtrate reduced in volume, obtains hardship after drying
Bean or pea extract.
Embodiment 3:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: Herba Sophorae alopecuroidis extract 5 parts, fat
8 parts of polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate (K12) 6 parts, coconut oil diethanol amide (6501) 5 parts,
Cocoamidopropyl betaine (CAB) 5 parts, glycerol 4 parts, propylene glycol 6 parts, isopropyl myristate 2 parts, ethylenediaminetetraacetic acid
Disodium (EDTA) 0.5 part, NaCl 1 part, carboxymethyl cellulose 3 parts, Kazon 0.1 part, the regulation of the outward appearance such as essence, pigment, pearling agent
Agent is appropriate, and citric acid adjusts pH to 7.0, adds distilled water and supplies 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows:
(1) take part distilled water and be heated to 55 DEG C, be sequentially added into polyoxyethylenated alcohol sodium sulfate according to formula
(AES), sodium lauryl sulphate (K12), coconut oil diethanol amide (6501), cocoamidopropyl betaine (CAB), sweet
Oil, propylene glycol, isopropyl myristate, disodiumedetate (EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to
All it is uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 7.0, adds surplus distilled water, continues to stir, and bottling gets product.
Wherein, the preparation method of Herba Sophorae alopecuroidis extract is: pulverized by herba Sophora alopecuroide, adds 60% ethanol of 6 times of volumes
Extraction with aqueous solution 3 times, each Extracting temperature is 80 DEG C, and extraction time is 1.5h, filters, filtrate reduced in volume, obtains after drying
Herba Sophorae alopecuroidis extract.
Embodiment 4:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: Herba Sophorae alopecuroidis extract 3 parts, fat
3 parts of polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate (K12) 3 parts, coconut oil diethanol amide (6501) 2 parts,
Cocoamidopropyl betaine (CAB) 3 parts, glycerol 2 parts, propylene glycol 3 parts, isopropyl myristate 1.5 parts, ethylenediamine tetrem
Acid disodium (EDTA) 0.2 part, NaCl 1 part, carboxymethyl cellulose 4 parts, Kazon 0.05 part, citric acid adjusts pH to 6.5, essence, color
The outward appearance regulators such as element, pearling agent are appropriate, add distilled water and supply 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows:
(1) take part distilled water and be heated to 50 DEG C, be sequentially added into polyoxyethylenated alcohol sodium sulfate according to formula
(AES), sodium lauryl sulphate (K12), coconut oil diethanol amide (6501), cocoamidopropyl betaine (CAB), sweet
Oil, propylene glycol, isopropyl myristate, disodiumedetate (EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to
All it is uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 6.5, adds surplus distilled water, continues to stir, and bottling gets product.
Wherein, the preparation method of Herba Sophorae alopecuroidis extract is: pulverized by Herba Sophorae alopecuroidis, and 80% ethanol adding 4 times of volumes is water-soluble
Liquid extracts 2 times, and each Extracting temperature is 60 DEG C, and extraction time is 2h, filters, and filtrate reduced in volume, obtains Herba Sophorae alopecuroidis after drying
Extract.
Embodiment 5:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: commercially available Sophora alopecuroides alkali content
It is the Herba Sophorae alopecuroidis extract 3 parts of 45%, polyoxyethylenated alcohol sodium sulfate (AES) 15 parts, sodium lauryl sulphate (K12) 3
Part, coconut oil diethanol amide (6501) 6 parts, cocoamidopropyl betaine (CAB) 10 parts, glycerol 8 parts, propylene glycol 2 parts,
Isopropyl myristate 1 part, disodiumedetate (EDTA) 0.5 part, NaCl 4 parts, carboxymethyl cellulose 2 parts, Kazon
0.03 part, citric acid adjusts pH to 6.8, and the outward appearance regulator such as essence, pigment, pearling agent is appropriate, adds distilled water and supplies 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows:
(1) take part distilled water and be heated to 60 DEG C, be sequentially added into polyoxyethylenated alcohol sodium sulfate according to formula
(AES), sodium lauryl sulphate (K12), coconut oil diethanol amide (6501), cocoamidopropyl betaine (CAB), sweet
Oil, propylene glycol, isopropyl myristate, disodiumedetate (EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to
All it is uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 6.8, adds surplus distilled water, continues to stir, and bottling gets product.
Embodiment 6:
A kind of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, contains in every 100 weight portion handwashing liquid: commercially available Sophora alopecuroides alkali content
The Herba Sophorae alopecuroidis extract of 45% 4 parts, polyoxyethylenated alcohol sodium sulfate (AES) 3 parts, sodium lauryl sulphate (K12) 10 parts,
Coconut oil diethanol amide (6501) 2 parts, cocoamidopropyl betaine (CAB) 4 parts, glycerol 3 parts, propylene glycol 2 parts, lima bean
Cool isopropyl propionate 3 parts, disodiumedetate (EDTA) 1 part, NaCl 1 part, carboxymethyl cellulose 5 parts, Kazon 0.2 part, lemon
PH to 7.0 is adjusted in lemon acid, and the outward appearance regulator such as essence, pigment, pearling agent is appropriate, adds distilled water and supplies 100 parts.
The preparation method of above-mentioned antibiotic skincare hand cleanser, step is as follows: (1) takes part distilled water and is heated to 55 DEG C, according to
Formula is sequentially added into polyoxyethylenated alcohol sodium sulfate (AES), sodium lauryl sulphate (K12), coconut oil diethanol amide
(6501), cocoamidopropyl betaine (CAB), glycerol, propylene glycol, isopropyl myristate, disodiumedetate
(EDTA), carboxymethyl cellulose, NaCl, be stirred continuously to being all uniformly dissolved；
(2) then, add the outward appearance regulators such as Herba Sophorae alopecuroidis extract, Kazon and appropriate amount of essence, pigment, pearling agent, and use
Citric acid adjusts pH to 7.0, adds surplus distilled water, continues to stir, and bottling gets product.
Effect application test example:
Efficacy assessments to embodiment 1-6 be presented herein below:
1, sensory evaluation
60 testers are equally divided into 6 groups, give test group sample at random by " double blinding " test, it is desirable to tester
Wash one's hands according to self daily custom of washing one's hands, evaluate foaming characteristic when handwashing liquid is washed one's hands, dirt-removing power, zest, flushing difficulty successively
Degree and salubrious sense of washing one's hands.Tester according to oneself feel mark, standards of grading use 5 points of systems, wherein foaming characteristic, decontaminations
Ability, to wash rear skinfeel worst with 1 point, and 5 points preferably calculate；Zest, flushing difficulty are best with 1 point, 5 points of worst calculating, finally
Mark with the sensory effects of each embodiment of mean values record, be shown in Table 1.
The sensory evaluation (unit: divide) of table 1 Herba Sophorae alopecuroidis antibiotic skincare hand cleanser hand-washing effect
As shown in Table 1, the handwashing liquid that embodiment of the present invention 1-6 prepares is respectively provided with certain hand-washing effect.Wherein, embodiment
The foaming characteristic of 4, to wash rear skinfeel the best, although the dirt-removing power of embodiment 5 is relatively strong, but rinses difficulty, to skin irritation
Increasing, embodiment 1,2,3,6 then decontamination gentleness does not stimulates.This is because complexed surfactant, preserving moisture and protecting skin in embodiment 4
Agent, fatting agent addition is on the low side, causes foaming characteristic, to wash rear skinfeel the best；And complexed surfactant adds in embodiment 5
Amount is relatively big, and dirt-removing power is relatively strong, but rinses difficulty, increases skin irritation.The present invention can add component by adjusting
Content obtains the handwashing liquid of different performance.
2, fungistatic effect evaluation
Bacteriostasis property measures and sets three groups, is respectively as follows: matched group (Con group), certain brand handwashing liquid group (A group) and system of the present invention
Standby handwashing liquid group (B 1-6 group).Each process group 6 repetition.The culture dish of Con group adds 15mL and is cooled to about 50 DEG C cultivations
Base.Take 1mL brand handwashing liquid and 15mL to be cooled to after the culture medium of about 50 DEG C fully mixes, join the cultivation of A group
In ware.The culture medium that the handwashing liquid of the present invention of 1mL and 15mL are cooled to about 50 DEG C fully mixes, and joins the training of B1-6 group
Support in ware.When the escherichia coli of activation, staphylococcus aureus are transferred and cultivated to OD600=0.6, take the bacterium solution of 200 μ L
Coated plate.Culture dish is positioned in the incubator of 37 DEG C cultivation 24h, carries out colony counting, and record with the method for plate culture count
Data, average, and result is as shown in table 2.
Wherein, antibacterial efficiency calculation formula is:
Antibacterial efficiency=(Con group total plate count-experimental group total plate count) × 100%/Con group total plate count
Table 2 Herba Sophorae alopecuroidis antibiotic skincare hand cleanser fungistatic effect
As shown in Table 2, Herba Sophorae alopecuroidis bacteriostatic skin-care handwashing liquid prepared by the present invention, there is prominent bacteriostasis property, the most excellent
In commercially available brand anti-bacterial hand lotion.
To sum up, Herba Sophorae alopecuroidis bacteriostatic skin-care handwashing liquid of the present invention has prominent bacteriostasis property, uses handwashing liquid to wash one's hands simultaneously
Rear skinfeel is joyful, has the effect of skin protection skin moistening to skin.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Therefore the restriction to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that, for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the guarantor of the present invention
Protect scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, it is characterised in that include the component of following parts by weight:
Wherein, containing mass fraction in described Herba Sophorae alopecuroidis extract is the total alkaloid of sophora alopecuroide of 30%-65%.
2. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 1, it is characterised in that described surfactant include cloudy from
At least one in sub-surface activating agent, nonionic surfactant and zwitterionic surfactant.
3. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 2, it is characterised in that described surfactant is described the moon
The mixture that ionic surface active agent, described nonionic surfactant and described zwitterionic surfactant are formed.
4. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 3, it is characterised in that described anion surfactant is
Polyoxyethylenated alcohol sodium sulfate and sodium lauryl sulphate, described nonionic surfactant is Oleum Cocois diethanol acyl
Amine, described zwitterionic surfactant is cocoamidopropyl betaine, described polyoxyethylenated alcohol sodium sulfate, institute
The weight ratio stating sodium lauryl sulphate, described coconut oil diethanol amide and described cocoamidopropyl betaine is 3-
15:3-10:2-6:3-10。
5. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 4, it is characterised in that described Herba Sophorae alopecuroidis antibiotic skin-care is washed one's hands
Liquid includes the component of following parts by weight: Herba Sophorae alopecuroidis extract 3 parts, polyoxyethylenated alcohol sodium sulfate 10 parts, dodecyl
4 parts of sodium sulfate, coconut oil diethanol amide 4 parts, cocoamidopropyl betaine 5 parts, diminishing moisture-retaining 9 parts, fatting agent 2
Part, chelating agen 0.5 part, thickening agent 4 parts, preservative 0.1 part.
6. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 1, it is characterised in that described diminishing moisture-retaining includes glycerol
With at least one in propylene glycol.
7. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 1, it is characterised in that described fatting agent is that myristic acid is different
In propyl ester, monoglyceride, glyceryl cocoate, glycerol cocoyl macrogol ester, octyl group hydroxy stearic acid ester, glycerol and pantothenylol
At least one.
8. Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 1, it is characterised in that described preservative is Kazon, benzene first
In acid sodium, methyl hydroxybenzoate, ethyl hydroxybenzoate, propylparaben, butoben and methylchloroisothiazandnone at least one
Kind.
9. the preparation method of a Herba Sophorae alopecuroidis antibiotic skincare hand cleanser, it is characterised in that comprise the following steps:
Distilled water is heated to 50-60 DEG C, is sequentially added into surfactant, diminishing moisture-retaining, fatting agent, chelating agen and thickening
Agent, is stirred continuously to being uniformly dissolved, is then sequentially added into Herba Sophorae alopecuroidis extract and preservative, continue to stir, and obtains bitter bean
Sub-antibiotic skincare hand cleanser.
10. the preparation method of Herba Sophorae alopecuroidis antibiotic skincare hand cleanser as claimed in claim 9, it is characterised in that described Herba Sophorae alopecuroidis
The preparation method of extract is: after herba Sophora alopecuroide or sophora alopecuroide being pulverized, add ethanol water or deionized water extraction 2-4
Secondary, the temperature every time extracted is 60-80 DEG C, and the time every time extracted is 0.5-2h, then filters, and by filtrate reduced in volume, does
Described Herba Sophorae alopecuroidis extract is obtained after dry.
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| CN106580861A (en) * | 2017-01-06 | 2017-04-26 | 华南理工大学 | Moso bamboo leaf extract liquid soap for deoiling, antibiosis and skincare |
| CN107049868A (en) * | 2017-05-03 | 2017-08-18 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pet detergent with sterilizing and preparation method thereof |
| CN107320392A (en) * | 2017-08-11 | 2017-11-07 | 重庆大学 | A kind of hand cleanser and preparation method thereof |
| CN109121393A (en) * | 2017-02-24 | 2019-01-01 | 拉芳家化股份有限公司 | A kind of anti-inflammatory lotion |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106580861A (en) * | 2017-01-06 | 2017-04-26 | 华南理工大学 | Moso bamboo leaf extract liquid soap for deoiling, antibiosis and skincare |
| CN109121393A (en) * | 2017-02-24 | 2019-01-01 | 拉芳家化股份有限公司 | A kind of anti-inflammatory lotion |
| CN107049868A (en) * | 2017-05-03 | 2017-08-18 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of pet detergent with sterilizing and preparation method thereof |
| CN107049868B (en) * | 2017-05-03 | 2020-06-05 | 中国农业科学院兰州畜牧与兽药研究所 | Disinfecting detergent for pets and preparation method thereof |
| CN107320392A (en) * | 2017-08-11 | 2017-11-07 | 重庆大学 | A kind of hand cleanser and preparation method thereof |
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Application publication date: 20161207 |