CN108653091A - Disposable hand sanitizing fluid and preparation method thereof - Google Patents
Disposable hand sanitizing fluid and preparation method thereof Download PDFInfo
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- CN108653091A CN108653091A CN201810725987.1A CN201810725987A CN108653091A CN 108653091 A CN108653091 A CN 108653091A CN 201810725987 A CN201810725987 A CN 201810725987A CN 108653091 A CN108653091 A CN 108653091A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The invention discloses a kind of disposable hand sanitizing fluids and preparation method thereof, it is mild as disposable hand sanitizing fluid formula made from raw material using ethyl alcohol, glycerine, hyaluronic acid, peppermint oil, citric acid, olive oil, camellia oil, soybean lecithin, biological complex enzyme, galic essential oil, essence, plant extracts, salt, pure water, it is nontoxic, it will not cause any harm to health, without rinsing, it is easy to use and carry, it is environmentally protective, nutrition hand skin can also be moistened while killing hand bacterium, enable both hands soft and moist flexible.In addition rationally coordinate between disposable hand sanitizing fluid each component provided by the invention, interact, make it have broad spectrum activity, can effectively kill a variety of bacterium, the disinfection effect duration is long, safe and efficient, protects hand skin.
Description
Technical field
The present invention relates to thimerosal field, especially a kind of disposable hand sanitizing fluid and preparation method thereof.
Background technology
Washing-free antibacterial hand sanitizer is a kind of novel sterile products, need not be rinsed with water after use, is suitable in water shortage
Under the conditions of use is cleaned and sterilized to hand, using simplicity, be applied to hospital clinically, public place, geology
Exploration, field work and daily life.
Therefore, such product was favored deeply by vast consumption because of the features such as its is easy to use, antibacterial effective, in recent years sales volume
It is very big always.The key component of non-water hand cleanser includes sterilizability ingredient and volatile ingredient, and it is low-boiling to be usually added into some
Alcohols solvent, principle is the cell wall that the antibacterial activities such as " alcohols " factor can effectively destroy bacterium, to make bacterial death,
And fall off from skin, just as the epidermal cell of aging falls off from skin, and alcohols is volatile, will not remain, therefore makes
With will not leave behind any residuals on the skin.But children's bears a pretty, delicate skin, to environmental factors such as drying, cold, humidities and
The chemical stimulations such as alkalinity, acidity are sensitive, and resistivity is weaker, using the meeting of some washing-free antibacterial hand sanitizers to the skin of children
Cause a degree of injury.
Invention content
In view of this, the object of the present invention is to provide a kind of disposable hand sanitizing fluid and preparation method thereof, it is thin killing hand
Nutrition hand skin can also be moistened while bacterium, enable both hands soft and moist flexible.
To achieve the goals above, the present invention provides the following technical solutions：
A kind of disposable hand sanitizing fluid, includes the raw material of following parts by weight：
Preferably, the biological complex enzyme is the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenation
Enzyme, amylase and cellulase.
Preferably, the essence is lavender oil, aloe flavour, lemon extract or watermelon essence.
Preferably, the plant extracts is angelica extract, camomile extract, Fructus Gleditsiae Abnormalis extract and Radix Glycyrrhizae extraction
Object.
The present invention also provides a kind of above-mentioned preparation methods of disinfection make up remover, include the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Essence and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
The present invention provides a kind of disposable hand sanitizing fluid and preparation method thereof, with ethyl alcohol, glycerine, hyaluronic acid, peppermint oil,
Citric acid, olive oil, camellia oil, soybean lecithin, biological complex enzyme, galic essential oil, essence, plant extracts, salt, pure water
It is mild for disposable hand sanitizing fluid formula made from raw material, it is nontoxic, it will not cause any harm to health, without punching
It washes, it is easy to use and carry, it is environmentally protective, nutrition hand skin can also be moistened while killing hand bacterium, enable both hands
It is soft and moist flexible.In addition rationally coordinate between disposable hand sanitizing fluid each component provided by the invention, interact, make it have wide
Spectrality can effectively kill a variety of bacterium, and the disinfection effect duration is long, safe and efficient, protect hand skin.
Specific implementation mode
A kind of disposable hand sanitizing fluid provided by the invention, includes the raw material of following parts by weight：
Above-mentioned technical proposal, with ethyl alcohol, glycerine, hyaluronic acid, peppermint oil, citric acid, olive oil, camellia oil, soybean phosphorus
Fat, biological complex enzyme, galic essential oil, essence, plant extracts, salt, pure water are that disposable hand sanitizing fluid made from raw material is matched
Fang Wenhe, it is nontoxic, it will not cause any harm to health, it is easy to use and carry without rinsing, it is environmentally protective,
Nutrition hand skin can also be moistened while killing hand bacterium, enable both hands soft and moist flexible.In addition provided by the invention
Rationally coordinate between disposable hand sanitizing fluid each component, interact, make it have broad spectrum activity, can effectively kill a variety of bacterium,
The disinfection effect duration is long, safe and efficient, protects hand skin.
Ethyl alcohol plays the role of disinfection, and meeting when volatilization in disposable hand sanitizing fluid.In the present invention, the parts by weight of ethyl alcohol
Number is 60~80 parts；In an embodiment of the present invention, the parts by weight of ethyl alcohol are 65~75 parts.
Glycerine plays the role of skin care.In the present invention, the parts by weight of glycerine are 5~8 parts；In the reality of the present invention
It applies in example, the parts by weight of glycerine are 5.5~7.5 parts；In other embodiments, the parts by weight of glycerine are 6~7 parts.
It is tender that hyaluronic acid enables to hand skin to slide, flexible.In the present invention, the parts by weight of hyaluronic acid are 2
~4 parts；In an embodiment of the present invention, the parts by weight of hyaluronic acid are 2.4~3.6 parts；In other embodiments, hyalomitome
The parts by weight of acid are 2.8~3.2 parts.
Peppermint oil can inhibit bacteria breed.In the present invention, the parts by weight of peppermint oil are 1~2 part；The present invention's
In embodiment, the parts by weight of peppermint oil are 1.2~1.8 parts；In other embodiments, the parts by weight of peppermint oil be 1.4~
1.6 part.
The effect of citric acid plays sterilization in disposable hand sanitizing fluid.In the present invention, the parts by weight of citric acid be 1~
2 parts；In an embodiment of the present invention, the parts by weight of citric acid are 1.2~1.8 parts；In other embodiments, the weight of citric acid
It is 1.4~1.6 parts to measure number.
Olive oil plays the role of moist hand skin.In the present invention, the parts by weight of olive oil are 2~3 parts；At this
In the embodiment of invention, the parts by weight of olive oil are 2.2~2.8 parts；In other embodiments, the parts by weight of olive oil are
2.4~2.6 parts.
Camellia oil has anti-solution to act on heavy metallic salt.In the present invention, the parts by weight of camellia oil are 0.5~1 part；At this
In the embodiment of invention, the parts by weight of camellia oil are 0.6~0.9 part；In other embodiments, the parts by weight of camellia oil are
0.7~0.8 part.
Soybean lecithin enables to disposable hand sanitizing fluid cleaning in sterilization process, keeps the smooth and moist of skin.
In the present invention, the parts by weight of soybean lecithin are 2~4 parts；In an embodiment of the present invention, the parts by weight of soybean lecithin are
2.4~3.5 parts；In other embodiments, the parts by weight of soybean lecithin are 2.7~3.2 parts.
Organic substance of the biological complex enzyme for hand of degrading, ensures the sanitation and hygiene of hand.In the embodiment of the present invention
In, biological complex enzyme is marine protein enzyme, glucose dehydrogenase, amylase and the cellulose that proposition is screened from marine microorganism
Enzyme.In other embodiments, the mass ratio of marine protein enzyme, glucose dehydrogenase, amylase and cellulase is (0.5~1)：
(0.4~0.6)：(1.2~1.8)：(0.8~1.5).
In the present invention, the parts by weight of biological complex enzyme are 0.1~0.2 part；In an embodiment of the present invention, biology is multiple
The parts by weight of synthase are 0.12~0.18 part；In other embodiments, the parts by weight of biological complex enzyme are 0.14~0.16
Part.
Galic essential oil plays the role of sterilization.In the present invention, the parts by weight of galic essential oil are 0~0.001 part；At this
In the embodiment of invention, the parts by weight of glycerine are 0.0001~0.001 part.
Essence enables to disposable hand sanitizing fluid smell pleasant, and lingering fragrance is stayed using defensive position.In an embodiment of the present invention, fragrant
Essence is lavender oil, aloe flavour, lemon extract or watermelon essence.
In the present invention, the parts by weight of essence are 0~0.01 part；In an embodiment of the present invention, the parts by weight of essence
Number is 0.001~0.01 part.
Plant extracts is killed and is inhibited to bacterium.In an embodiment of the present invention, plant extracts is to work as
Return extract, camomile extract, Fructus Gleditsiae Abnormalis extract and licorice.In other embodiments, angelica extract, chamomile
The mass ratio of extract, Fructus Gleditsiae Abnormalis extract and licorice is (2~3)：(3~5)：(1~2)：(0.6~1).
In the present invention, the parts by weight of plant extracts are 1~2 part；In an embodiment of the present invention, plant extracts
Parts by weight be 1.2~1.8 parts；In other embodiments, the parts by weight of plant extracts are 1.4~1.6 parts.
Salt enables to hand inactivation of bacteria.In the present invention, the parts by weight of salt are 2~3 parts；The present invention's
In embodiment, the parts by weight of salt are 2.2~2.8 parts；In other embodiments, the parts by weight of salt are 2.4~2.6
Part.
In the present invention, the parts by weight of pure water are 20~30 parts；In an embodiment of the present invention, the weight of pure water
Number is 22~28 parts；In other embodiments, the parts by weight of pure water are 24~26 parts.
The present invention also provides a kind of above-mentioned preparation methods of disposable hand sanitizing fluid, include the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt 4~26, plant extracts are mixed uniformly and obtains first
Mixture；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Essence and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Wherein, ethyl alcohol, glycerine, hyaluronic acid, peppermint oil, citric acid, olive oil, camellia oil, soybean lecithin, biology are compound
Enzyme, galic essential oil, essence, plant extracts, salt, pure water are same as above, and details are not described herein.
In order to further illustrate the present invention, with reference to embodiment to a kind of disposable hand sanitizing fluid provided by the invention and its
Preparation method is described in detail, but cannot they be interpreted as limiting the scope of the present invention.
Embodiment 1
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
60 parts of ethyl alcohol, 5.5 parts of glycerine, 2.8 parts of hyaluronic acids, 1.4 portions of peppermint oils, 1.5 parts of citric acids, 2.4 parts of olive oil,
0.7 part of camellia oil, 2.7 parts of soybean lecithins, 0.14 part of biological complex enzyme, 0.0001 part of galic essential oil, 1.4 parts of plant extracts,
2.6 portions of salt, 24 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.7：0.55：1.7：0.8；
Plant extracts includes that mass ratio is 3：5：1.3：0.7 angelica extract, camomile extract, Fructus Gleditsiae Abnormalis extract
And licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Essence and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 2
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
65 parts of ethyl alcohol, 6 parts of glycerine, 2 parts of hyaluronic acids, 1.2 portions of peppermint oils, 1.4 parts of citric acids, 2.8 parts of olive oil, 0.6
Part camellia oil, 3.5 parts of soybean lecithins, 0.18 part of biological complex enzyme, 0.001 part of lavender oil, 1.2 parts of plant extracts, 2.8
Part salt, 22 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.8：0.6：1.6：1.5；
Plant extracts includes that mass ratio is 2.4：4.5：1.9：0.8 angelica extract, camomile extract, gleditsia sinensis carry
Take object and licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Lavender oil and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 3
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
80 parts of ethyl alcohol, 7 parts of glycerine, 4 parts of hyaluronic acids, 1 portion of peppermint oil, 1 part of citric acid, 2.6 parts of olive oil, 1 portion of camellia
Oil, 2 parts of soybean lecithins, 0.1 part of biological complex enzyme, 0.0001 part of galic essential oil, 0.01 part of aloe flavour, 1 part of plant extracts,
2 portions of salt, 26 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.5：0.45：1.2：1；
Plant extracts includes that mass ratio is 2.8：3.5：1.7：0.9 angelica extract, camomile extract, gleditsia sinensis carry
Take object and licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Aloe flavour and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 4
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
75 parts of ethyl alcohol, 8 parts of glycerine, 3.6 parts of hyaluronic acids, 1.6 portions of peppermint oils, 2 parts of citric acids, 2.2 parts of olive oil, 0.9
Part camellia oil, 3.2 parts of soybean lecithins, 0.16 part of biological complex enzyme, 0.0002 part of galic essential oil, 0.005 part of lemon extract, 1.6
Part plant extracts, 2.4 portions of salt, 28 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.9：0.4：1.8：1.3；
Plant extracts includes that mass ratio is 2：4.8：1.5：1 angelica extract, camomile extract, Fructus Gleditsiae Abnormalis extract
And licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Lemon extract and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 5
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
70 parts of ethyl alcohol, 7.5 parts of glycerine, 3.2 parts of hyaluronic acids, 1.8 portions of peppermint oils, 1.6 parts of citric acids, 2 parts of olive oil,
0.5 part of camellia oil, 4 parts of soybean lecithins, 0.12 part of biological complex enzyme, 0.001 part of galic essential oil, 0.003 part of watermelon essence, 2 parts
Plant extracts, 3 portions of salt, 20 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.6：0.48：1.4：1.1；
Plant extracts includes that mass ratio is 2.6：3：2：0.6 angelica extract, camomile extract, Fructus Gleditsiae Abnormalis extract
And licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Watermelon essence and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 6
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
68 parts of ethyl alcohol, 5 parts of glycerine, 2.4 parts of hyaluronic acids, 2 portions of peppermint oils, 1.8 parts of citric acids, 3 parts of olive oil, 0.8 part
Camellia oil, 2.4 parts of soybean lecithins, 0.2 part of biological complex enzyme, 0.0008 part of galic essential oil, 0.008 part of lemon extract, 1.8 parts of plants
Object extract, 2.2 portions of salt, 30 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 1：0.52：1.3：1.4；
Plant extracts includes that mass ratio is 2.2：3.6：1：0.8 angelica extract, camomile extract, gleditsia sinensis extraction
Object and licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Lemon extract and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Embodiment 7
Disposable hand sanitizing fluid includes the raw material of following parts by weight：
70 parts of ethyl alcohol, 6.5 parts of glycerine, 3 parts of hyaluronic acids, 1.5 portions of peppermint oils, 1.5 parts of citric acids, 2.5 parts of olive oil,
0.75 part of camellia oil, 3 parts of soybean lecithins, 0.15 part of biological complex enzyme, 0.0005 part of galic essential oil, 0.005 part of aloe flavour,
1.5 parts of plant extracts, 2.5 portions of salt, 25 parts of pure water；
Biological complex enzyme be the marine protein enzyme that proposition is screened from marine microorganism, glucose dehydrogenase, amylase and
Cellulase, marine protein enzyme, glucose dehydrogenase, amylase and cellulase mass ratio be 0.75：0.5：1.5：1.2；
Plant extracts includes that mass ratio is 2.5：4：1.5：0.8 angelica extract, camomile extract, gleditsia sinensis extraction
Object and licorice.
The preparation method of disposable hand sanitizing fluid, includes the following steps：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixing
Object；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) by the first obtained mixtures of step a) and step b) obtain second mixing mix, and be added galic essential oil,
Aloe flavour and biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
1, toxicity detection
Sample：Disposable hand sanitizing fluid made from Examples 1 to 7 is mixed.
Test method：Select 20 ICR mouse, half male and half female, when experiment that 5.0g samples is taken to add deionized water to 10ml, phase
When in 0.5g/ml；Using primary oral tank stomach mode, contamination amount is given by 0.1ml/10g weight；After contamination, mouse is observed
Poisoning manifestations and death condition observe 14d, and to dead animal and observation period, everywhere dead animal carries out gross anatomy, finds
Abnormal tissue or internal organs then further does histopathological examination.
Experimental result：After contamination, have no that experiment mice has Novel presentation and death condition to occur, the observation period is dead dynamic everywhere
Object gross anatomy shows no obvious abnormalities change, is shown in Table 1, which is orally all higher than 5.0g/kg bodies to bisexuality chmice acute
Weight is nontoxic according to the true border of acute toxicity grading criteria.
1 toxicity detection result of table
2, skin irritation test
Sample：Disposable hand sanitizing fluid made from Examples 1 to 7 is mixed.
Test method：Select healthy adult, the intact New Zealand rabbits of skin 3, before experiment for 24 hours, every rabbit back backbone
Each one piece of both sides cropping, area are 3.0cm × 3.0cm；Sample 0.5ml is directly applied to the left side that area is 2.5cm × 2.5cm
On unhairing intact skin, 4h removes removal of residue with warm water after smearing；Observe result afterwards for 24 hours；Primary, continuous smearing is smeared daily
14d；Cropping when necessary；The other side applies deionized water and compares.
Observation instruction, observes and records dermoreaction situation, presses daily《Disinfection technology standard》Version carries out respectively within 2002
Skin wound repair scores and stimulus intensity classification.
2 skin irritation test result of table
Test result：To the multiple Skin Irritation Test of rabbit, every animal integral mean value is 0.10 to the sample daily, according to
《Disinfection technology standard》Skin irritatin strength grading belongs to nonirritant.
3, bactericidal effect
Experiment is divided into test group 1~7, and the disposable hand-wrist bones that Examples 1 to 7 is prepared are respectively adopted in test group 1~7
Liquid tests every group of disposable hand sanitizing fluid and staphylococcus aureus, Escherichia coli, Candida albicans is acted on 2 minutes and being killed respectively
Bacterium rate, the results are shown in Table 3.
3 sterilization test result of table
The disposable hand sanitizing fluid has the function of great broad-spectrum antibacterial, sterilization, has effect to various bacteria and fungi,
With long acting antibiotic effect, and the washing-free antibacterial hand sanitizer is gentle, small to skin damage, nonirritant.
Above description enables professional and technical personnel in the field to realize or using this to being stated in the disclosed embodiments
It is bright, it enables those skilled in the art to implement or use the present invention.Various modifications to these embodiments are to this field
It will be apparent for professional technician, the general principles defined herein can be in the spirit for not departing from the present invention
Or in the case of range, realize in other embodiments.Therefore, the present invention is not intended to be limited to these implementations shown in this article
Example, and it is to fit to the widest range consistent with principles disclosed herein and novel features.
Claims (5)
1. a kind of disposable hand sanitizing fluid and preparation method thereof, which is characterized in that include the raw material of following parts by weight：
2. disposable hand sanitizing fluid as described in claim 1, which is characterized in that the biological complex enzyme is from marine microorganism
Screen marine protein enzyme, glucose dehydrogenase, amylase and the cellulase proposed.
3. disposable hand sanitizing fluid as described in claim 1, which is characterized in that the essence be lavender oil, aloe flavour,
Lemon extract or watermelon essence.
4. disposable hand sanitizing fluid as described in claim 1, which is characterized in that the plant extracts is angelica extract, ocean
Flos Chrysanthemi extract, Fructus Gleditsiae Abnormalis extract and licorice.
5. a kind of preparation method such as the disposable hand sanitizing fluid of Claims 1 to 4 any one of them, which is characterized in that including with
Lower step：
A) it is added into pure water after hyaluronic acid, citric acid, salt, plant extracts are mixed uniformly and obtains the first mixture；
B) after addition glycerine, peppermint oil, olive oil, camellia oil stir evenly into ethyl alcohol, the second mixture is obtained；
C) the second mixing that the first obtained mixtures of step a) and step b) are obtained is mixed, and galic essential oil, essence is added
And biological complex enzyme, after mixing to get disposable hand sanitizing fluid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810725987.1A CN108653091A (en) | 2018-07-04 | 2018-07-04 | Disposable hand sanitizing fluid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810725987.1A CN108653091A (en) | 2018-07-04 | 2018-07-04 | Disposable hand sanitizing fluid and preparation method thereof |
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|---|---|---|---|
| CN201810725987.1A Withdrawn CN108653091A (en) | 2018-07-04 | 2018-07-04 | Disposable hand sanitizing fluid and preparation method thereof |
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| CN (1) | CN108653091A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
| CN112057401A (en) * | 2020-09-18 | 2020-12-11 | 杭州健驰医疗科技有限公司 | Hand-washing-free composite alcohol disinfectant and preparation method thereof |
-
2018
- 2018-07-04 CN CN201810725987.1A patent/CN108653091A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111714424A (en) * | 2020-08-07 | 2020-09-29 | 泰州市榕兴医疗用品股份有限公司 | Hand-washing-free disinfection gel |
| CN112057401A (en) * | 2020-09-18 | 2020-12-11 | 杭州健驰医疗科技有限公司 | Hand-washing-free composite alcohol disinfectant and preparation method thereof |
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