CN109350570A - A kind of cosmetics preservative and its application based on natural plant composition - Google Patents
A kind of cosmetics preservative and its application based on natural plant composition Download PDFInfo
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- CN109350570A CN109350570A CN201811268674.4A CN201811268674A CN109350570A CN 109350570 A CN109350570 A CN 109350570A CN 201811268674 A CN201811268674 A CN 201811268674A CN 109350570 A CN109350570 A CN 109350570A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of cosmetics preservative based on natural plant composition and its application, which is compounded by the following raw material by mass parts: 20~30 parts of litsea cubeba oil, 5~15 parts of oldenlandia diffusa extracting solution, 60~70 parts of dihydric alcohol mixed liquor.For the dihydric alcohol mixed liquor by 1,2- pentanediol and 1,2- hexylene glycol is that 2~4:1 is mixed in mass ratio.The present invention uses the mixing binary alcohol extract of oldenlandia diffusa, it is compounded with litsea cubeba oil, dihydric alcohol mixed liquor and the excellent compound preservative of highly-safe one kind, broad-spectrum antiseptic, anti-corrosion effect is made, substitute traditional chemical synthesis preservative, the potential security risk of chemical synthesis preservative is reduced, there are biggish application value and market prospects.
Description
Technical field
The present invention relates to the technical fields of cosmetics, in particular to a kind of cosmetics preservative based on natural plant composition
And its application.
Background technique
Cosmetics are full of nutrition, moisture is sufficient, be particularly suitable for microorganism growth and breeding, therefore, production, save and
It is highly prone to the pollution of microorganism in use process and causes putrid and deteriorated.The product of microbial contamination there are security risk,
Skin allergy, stimulation can be caused even to infect, endangered to the health care belt of consumer, therefore, anti-corrosion is matter in Cosmetic Manufacture
A highly important link of control is measured, addition preservative is to be generally used and effective method.
At present allow in the world using about more than 60 kinds of preservative, there are commonly more than ten, China exists
Mutatis mutandis preservative has 51 kinds in " cosmetics safety technical specification " (2015 editions), belongs to chemical synthesis substance, these are anti-
Mostly there is certain irritation, sensitization even bio-toxicity, safety to have been a concern for rotten agent, relevant laws and regulations and mark
Standard has stringent limitation to its usage amount and use scope in cosmetics.
Mild, safe and efficient preservative is researched and developed, is always the important subject of cosmetic field.Many plants
All there is the effect of antiphlogistic antibacterial corrosion-resistant, according to the anti-inflammatory anti-corrosive practice of existing traditional Chinese medicine, found from plant it is natural, green,
Safe and efficient preservative is an important directions of current cosmetics corrosion-resistant field.
Summary of the invention
Present invention aim to provide a kind of highly-safe, broad-spectrum antiseptic, favorable anti-corrosion effect based on natural plants
The cosmetics preservative of ingredient, the present invention use with good preservative efficacy and moistening effect 1,2- pentanediol and 1,2- oneself two
Alcohol mixed liquor is as extractant, obtained extract favorable anti-corrosion effect, and eliminates solvent removing step, simplifies and extracts work
Skill, the present invention also provides the applications based on the cosmetics preservative of natural plant composition in cosmetics.
To achieve the above object, a kind of cosmetics preservative based on natural plant composition provided by the present invention, this is anti-
Rotten agent is compounded by the following raw material by mass parts: 20~30 parts of litsea cubeba oil, 5~15 parts of oldenlandia diffusa extracting solution, two
60~70 parts of first alcohol mixed liquor.
Preferably, which is compounded by the following raw material by mass parts: 22~28 parts of litsea cubeba oil, oldenlandia
7~12 parts of careless extracting solution, 62~68 parts of dihydric alcohol mixed liquor.
Most preferably, which is compounded by the following raw material by mass parts: 26 parts of litsea cubeba oil, oldenlandia diffusa mention
Take 10 parts of liquid, 64 parts of dihydric alcohol mixed liquor.
Preferably, the dihydric alcohol mixed liquor is in mass ratio by 1,2- pentanediol and 1,2- hexylene glycol
2~4:1 is mixed.
Preferably, the litsea cubeba oil is prepared by the following method:
1) fruit of a cubeb litsea tree fresh fruit is subjected to 1~2min of broken wall treatment, obtains the slurry of fruit of a cubeb litsea tree fresh fruit；
2) in mass ratio it is that 1:2~5 mix with distilled water by the resulting slurry of step 1), is 120~130 DEG C in temperature
2~3h is distilled using steam distillation in oil bath, collects upper oil phase to get litsea cubeba oil is arrived.
Preferably, the oldenlandia diffusa extracting solution is prepared by the following method:
1) by oldenlandia diffusa complete stool by clean, drying and pulverization process, with lower part of screen after 40~60 mesh sieves
Get Spreading Hedyotis Herb；
It 2) is that 1:4~5 mix by solid-liquid mass ratio with dihydric alcohol mixed liquor by the resulting Spreading Hedyotis Herb of step 1),
1~2h of mechanical shaking extraction under conditions of temperature is 90~100 DEG C, then filtered while hot with 100~200 meshes, filtrate is obtained, wherein
For dihydric alcohol mixed liquor by 1,2- pentanediol and 1,2- hexylene glycol is that 2~4:1 is mixed in mass ratio；
3) 20~30min is centrifuged after being cooled to room temperature the resulting filtrate of step 2) at 4000~4500rpm, takes supernatant
Liquid is by active carbon decolorization to get oldenlandia diffusa extracting solution.
It is described to be based on natural plants the present invention also provides a kind of application of cosmetics preservative based on natural plant composition
The cosmetics preservative of ingredient makes an addition in cosmetics, and quality dosage is 1~3%.
It is described clean the present invention also provides a kind of application based on the cosmetics preservative of natural plant composition in face cleaning cream
Face cream is made of the raw material of following mass parts: 10.0~14.0 parts of stearic acid, 12.0~16.0 parts of myristic acid, lauric acid 3.0
~7.0 parts, 2.0~4.0 parts of jojoba oil, 13.0~17.0 parts of sorbierite (mass concentration 70%), glycerol 8.0~13.0
Part, 8.0~12.0 parts of 1,3-BDO, 1.0~3.0 parts of PEG-20 stearate, N- acyl-N-methyl sodium taurocholate 3.0~
6.0 parts, 0.15~0.3 part of EDETATE SODIUM, 4.0~6.9 parts of potassium hydroxide (total saponification rate is made to reach 70~80%) and as above
2.0~3.0 parts of cosmetics preservative based on natural plant composition stated, surplus is water, and the sum of the mass fraction of each raw material is
100 parts.
Preferably, the face cleaning cream is made of the raw material of following mass parts: 10.0 parts of stearic acid, Pork and beans
Cool sour 12.0 parts, 3.0 parts of lauric acid, 2.0 parts of jojoba oil, 13.0 parts of sorbierite (mass concentration 70%), 13.0 parts of glycerol,
12.0 parts of 1,3-BDO, 3.0 parts of PEG-20 stearate, 6.0 parts of N- acyl-N-methyl sodium taurocholate, EDETATE SODIUM 0.3
Part, 4.0 parts of potassium hydroxide (saponification rate is made to reach 70%) and such as above-mentioned cosmetics preservative based on natural plant composition
3.0 parts, water is 18.7 parts.
Preferably, the face cleaning cream is made of the raw material of following mass parts: 14.0 parts of stearic acid, Pork and beans
Cool sour 16.0 parts, 7.0 parts of lauric acid, 4.0 parts of jojoba oil, 17.0 parts of sorbierite (mass concentration 70%), 8.0 parts of glycerol,
8.0 parts of 1,3-BDO, 1.0 parts of PEG-20 stearate, 3.0 parts of N- acyl-N-methyl sodium taurocholate, EDETATE SODIUM 0.15
Part, 6.9 parts of potassium hydroxide (total saponification rate reaches 80%) and such as above-mentioned cosmetics preservative based on natural plant composition
2.0 parts, water is 12.95 parts.
The present invention also provides a kind of application based on the cosmetics preservative of natural plant composition in face cream, the shields
Skin frost is made of the raw material of following mass parts: 2.0~6.0 parts of rice bran oil, 2.0~4.0 parts of jojoba oil, hexadecanol 1.0~2.0
Part, 0.8~1.5 part of glycerin monostearate, 4.0~7.0 parts of glycerol, 4.0~7.0 parts of 1,2-PD, odium stearate 1.0~
1.5 parts, 0.4~1.0 part of cetostearyl alcohol pentoside and such as above-mentioned cosmetics preservative based on natural plant composition
1.0~3.0 parts, surplus is water, and the sum of mass fraction of each raw material is 100 parts.
Preferably, the face cream is made of the raw material of following mass parts: 6.0 parts of rice bran oil, flash
Bar 2.0 parts of oil, 2.0 parts of hexadecanol, 0.8 part of glycerin monostearate, 7.0 parts of glycerol, 4.0 parts of 1,2-PD, odium stearate
1.5 parts, 0.4 part of cetostearyl alcohol pentoside and such as 3.0 parts of the above-mentioned cosmetics preservative based on natural plant composition,
Water is 73.3 parts.
Preferably, the face cream is made of the raw material of following mass parts: 2.0 parts of rice bran oil, flash
Bar 4.0 parts of oil, 1.0 parts of hexadecanol, 1.5 parts of glycerin monostearate, 4.0 parts of glycerol, 7.0 parts of 1,2-PD, odium stearate
1.0 parts, 1.0 parts of cetostearyl alcohol pentoside and such as 1.0 parts of the above-mentioned cosmetics preservative based on natural plant composition,
Water is 77.5 parts.
Compared with prior art, the present invention has the advantage that
First, litsea cubeba oil of the invention is to distill the obtained volatilization with lemon faint scent from the fruit of the fruit of a cubeb litsea tree
Property oil, main component is citral, and content is up to 70%~80%, also contains limonene, methyl heptenone, linalool, perfume (or spice)
Leaf-alcohol, firpene etc., litsea cubeba oil is to aspergillus flavus, aspergillus niger, Penicillium citrinum, bread mold, Rhizopus oryzae, Mucor racemosus, golden yellow grape
The microorganisms such as coccus, bacillus subtilis, Escherichia coli have significant inhibitory or killing effect, and it is extremely safe to human body, is
Food flavor, the medical material being allowed to use, and it is deep by a kind of favorite daily flavored oils of common people；Oldenlandia diffusa is rich
Containing Flavonoid substances, flavone compound is the biological active matter beneficial to human body, while having antibacterial, bactericidal effect, and mountain is grey
Sub- essential oil and the cooperation of oldenlandia diffusa extracting solution are synergistic, improve fungistatic effect, to Staphylococcus aureus, Escherichia coli, white
Color reads coccus, copper vacation unit cell Pseudomonas aeruginosa (pseudomonas aeruginosa) etc. and all shows preferable anti-corrosion effect, especially to golden yellow
Staphylococcus effect is the most obvious.
Second, 1, the 2- pentanediol and 1 that the present invention uses, 2- hexylene glycol has excellent moistening effect, as a kind of peace
Complete mild moisturizer largely uses in cosmetics, while the two also shows the antibacterial action of wide spectrum to bacterium and fungi.
In the present invention, 1,2- pentanediol, 1,2- hexylene glycol and the grey seed essential oil in mountain and oldenlandia diffusa extracting solution are used in compounding, and collaboration increases
Effect, fungistatic effect are significant.
Third, 1, the 2- pentanediol and 1 that the present invention uses, 2- hexylene glycol is both the moisturizer with anti-corrosion effect, still
Good solvent, the present invention use 1,2- pentanediol and 1, and the mixed liquor of 2- hexylene glycol extracts oldenlandia diffusa as extractant
Active constituent eliminates the removing step of subsequent solvent, simplifies extraction process.
Fourth, the present invention uses oldenlandia diffusa extracting solution, is compounded with litsea cubeba oil and a kind of highly-safe, wide spectrum is made
The excellent compound preservative of antibacterial, anti-corrosion effect, the chemical synthesis preservative that substitution tradition uses reduce traditional chemical synthesis
The potential security risk of preservative, meet current cosmetics health, green theory, the present invention have biggish application value with
Market prospects.
Specific embodiment
The present invention is described in further detail combined with specific embodiments below.
Embodiment 1: of the invention to be compounded by the following raw material by mass parts based on the cosmetics preservative of natural plant composition
It forms: 20 parts of litsea cubeba oil, 15 parts of oldenlandia diffusa extracting solution, 65 parts of dihydric alcohol mixed liquor；Wherein, dihydric alcohol mixed liquor by
1,2- pentanediol and 1,2- hexylene glycol mix in mass ratio for 2:1.
Litsea cubeba oil is prepared by the following method: fruit of a cubeb litsea tree fresh fruit being used wall-breaking machine broken wall treatment 2min, is obtained
The slurry of fruit of a cubeb litsea tree fresh fruit；It with distilled water is in mass ratio that 1:5 is mixed by resulting slurry, in the oil bath that temperature is 130 DEG C
3h is distilled using steam distillation, collects upper oil phase to get litsea cubeba oil is arrived.
The preparation method of oldenlandia diffusa extracting solution includes the following steps: to take oldenlandia diffusa complete stool to be cleaned, drying, with
And pulverization process, then get Spreading Hedyotis Herb with lower part of screen after 60 mesh sieves, two are added by the solid-liquid mass ratio of 1:5
First alcohol mixed liquor mechanical shaking extraction 2h at 100 DEG C, is filtered while hot with 200 meshes, filtrate be cooled to room temperature after at 4500rpm from
Heart 30min, supernatant is with active carbon decoloring to get oldenlandia diffusa extracting solution.Wherein, dihydric alcohol mixed liquor is by 1,2- pentanediol
It is mixed with 1,2- hexylene glycol 2:1 in mass ratio.
Embodiment 2: of the invention to be compounded by the following raw material by mass parts based on the cosmetics preservative of natural plant composition
It forms: 26 parts of litsea cubeba oil, 10 parts of oldenlandia diffusa extracting solution, 64 parts of dihydric alcohol mixed liquor.Wherein, dihydric alcohol mixed liquor by
1,2- pentanediol and 1,2- hexylene glycol mix in mass ratio for 2.5:1.
Litsea cubeba oil is prepared by the following method: fruit of a cubeb litsea tree fresh fruit being used wall-breaking machine broken wall treatment 2min, is obtained
The slurry of fruit of a cubeb litsea tree fresh fruit；It with distilled water is in mass ratio that 1:2 is mixed by resulting slurry, in the oil bath that temperature is 120 DEG C
2h is distilled using steam distillation, collects upper oil phase to get litsea cubeba oil is arrived.
The preparation method of oldenlandia diffusa extracting solution includes the following steps: to take oldenlandia diffusa complete stool to be cleaned, drying, with
And pulverization process, then get Spreading Hedyotis Herb with lower part of screen after 40 mesh sieves, two are added by the solid-liquid mass ratio of 1:4
First alcohol mixed liquor mechanical shaking extraction 2h at 90 DEG C, is filtered while hot with 100 meshes, filtrate be cooled to room temperature after at 4000rpm from
Heart 30min, supernatant is with active carbon decoloring to get oldenlandia diffusa extracting solution.Wherein, dihydric alcohol mixed liquor is by 1,2- pentanediol
It is mixed with 1,2- hexylene glycol 2:1 in mass ratio.
Embodiment 3: of the invention to be compounded by the following raw material by mass parts based on the cosmetics preservative of natural plant composition
It forms: 25 parts of litsea cubeba oil, 10 parts of oldenlandia diffusa extracting solution, 65 parts of dihydric alcohol mixed liquor.Wherein, dihydric alcohol mixed liquor by
1,2- pentanediol and 1,2- hexylene glycol mix in mass ratio for 3.5:1.
Litsea cubeba oil is prepared by the following method: fruit of a cubeb litsea tree fresh fruit being used wall-breaking machine broken wall treatment 1.5min, is obtained
To the slurry of fruit of a cubeb litsea tree fresh fruit；It with distilled water is in mass ratio that 1:4.5 is mixed by resulting slurry, the oil for being 125 DEG C in temperature
2h is distilled using steam distillation in bath, collects upper oil phase to get litsea cubeba oil is arrived.
The preparation method of oldenlandia diffusa extracting solution includes the following steps: to take oldenlandia diffusa complete stool to be cleaned, drying, with
And pulverization process, then get Spreading Hedyotis Herb with lower part of screen after 60 mesh sieves, it is added by the solid-liquid mass ratio of 1:4.5
Dihydric alcohol mixed liquor mechanical shaking extraction 2h at 100 DEG C, is filtered while hot with 150 meshes, is centrifuged at 4500rpm after filtrate is cooling
20min, supernatant is with active carbon decoloring to get oldenlandia diffusa extracting solution.Wherein, dihydric alcohol mixed liquor by 1,2- pentanediol and
1,2- hexylene glycol 3:1 in mass ratio is mixed.
Embodiment 4: of the invention to be compounded by the following raw material by mass parts based on the cosmetics preservative of natural plant composition
It forms: 22 parts of litsea cubeba oil, 10 parts of oldenlandia diffusa extracting solution, 68 parts of dihydric alcohol mixed liquor.Wherein, dihydric alcohol mixed liquor by
1,2- pentanediol and 1,2- hexylene glycol mix in mass ratio for 3:1.
Litsea cubeba oil is prepared by the following method: fruit of a cubeb litsea tree fresh fruit being used wall-breaking machine broken wall treatment 1min, is obtained
The slurry of fruit of a cubeb litsea tree fresh fruit；It with distilled water is in mass ratio that 1:4 is mixed by resulting slurry, in the oil bath that temperature is 125 DEG C
2.5h is distilled using steam distillation, collects upper oil phase to get litsea cubeba oil is arrived.
The preparation method of oldenlandia diffusa extracting solution includes the following steps: to take oldenlandia diffusa complete stool to be cleaned, drying, with
And pulverization process, then get Spreading Hedyotis Herb with lower part of screen after 40 mesh sieves, two are added by the solid-liquid mass ratio of 1:4
First alcohol mixed liquor mechanical shaking extraction 1h at 95 DEG C, is filtered while hot with 150 meshes, is centrifuged at 4200rpm after filtrate is cooling
30min, supernatant is with active carbon decoloring to get oldenlandia diffusa extracting solution.Wherein, dihydric alcohol mixed liquor by 1,2- pentanediol and
1,2- hexylene glycol 4:1 in mass ratio is mixed.
Embodiment 5: of the invention to be compounded by the following raw material by mass parts based on the cosmetics preservative of natural plant composition
It forms: 30 parts of litsea cubeba oil, 10 parts of oldenlandia diffusa extracting solution, 60 parts of dihydric alcohol mixed liquor.Wherein, dihydric alcohol mixed liquor by
1,2- pentanediol and 1,2- hexylene glycol mix in mass ratio for 4:1.
Litsea cubeba oil is prepared by the following method: fruit of a cubeb litsea tree fresh fruit being used wall-breaking machine broken wall treatment 2min, is obtained
The slurry of fruit of a cubeb litsea tree fresh fruit；It with distilled water is in mass ratio that 1:4 is mixed by resulting slurry, in the oil bath that temperature is 120 DEG C
3h is distilled using steam distillation, collects upper oil phase to get litsea cubeba oil is arrived.
The preparation method of oldenlandia diffusa extracting solution includes the following steps: to take oldenlandia diffusa complete stool to be cleaned, drying, with
And pulverization process, then get Spreading Hedyotis Herb with lower part of screen after 40 mesh sieves, two are added by the solid-liquid mass ratio of 1:4
First alcohol mixed liquor mechanical shaking extraction 1h at 100 DEG C, is filtered while hot with 200 meshes, is centrifuged at 4000rpm after filtrate is cooling
30min, supernatant is with active carbon decoloring to get oldenlandia diffusa extracting solution.Wherein, dihydric alcohol mixed liquor by 1,2- pentanediol and
1,2- hexylene glycol 2:1 in mass ratio is mixed.
Effect example 1: bacteriostatic test
1. material
1.1 test materials: the preservative that Examples 1 to 4 is prepared.
1.2 tested strains:
Bacterium: staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa.
Mould and saccharomycete: saccharomyces cerevisiae, aspergillus niger.
1.3 for trying culture medium:
Bacteria culture media: nutrient agar, it is spare after 121 DEG C of high pressure sterilization 30min.
Microzyme culture medium: YPD culture medium, it is spare after 115 DEG C of high pressure sterilization 30min.
Mould medium: Czapek's medium, it is spare after 115 DEG C of high pressure sterilization 30min.
2. experimental method
The preparation of 2.1 bacteria suspensions
Each bacterial strain is inoculated into corresponding medium slant respectively before experiment.Bacterium (staphylococcus aureus, large intestine bar
Bacterium, pseudomonas aeruginosa) it is cultivated 36~48 hours in 36 ± 1 DEG C of constant incubators, appropriate bacterium colony is picked them separately in sterile
It is mixed in physiological saline, certain density bacteria suspension is made, bacterial suspension total concentration is about 1.0 × 108CFU/ml is placed in 4 DEG C
It stores spare.Mould is cultivated 120 hours in 27 ± 1 DEG C of constant incubators.24 are cultivated in 27 ± 1 DEG C of constant incubators of saccharomycete
Hour.It picks them separately appropriate yeast and mold bacterium colony to be uniformly mixed in sterile saline, it is outstanding that certain density bacterium is made
Liquid, the concentration of mould suspension are about 1.0 × 106CFU/ml, the concentration of saccharomycete spore suspension are about 1.0 × 108CFU/ml is set
It is spare in 4 DEG C of storages.
2.2 bacteriostatic tests use disc diffusion method, carry out under whole aseptic condition.Filter paper is broken into diameter with punch
The circular filter paper piece of 6mm, 121 DEG C of sterilizing-dryings are spare.Filter paper is soaked in respectively in Examples 1 to 4 group preservative
20min will pour into culture dish respectively after prepared solid medium sterilizing, after solidification to be cooled, it is outstanding to draw 0.2ml bacterium
Liquid is uniform in being coated on plate.It clamps the filter paper impregnated in preservative respectively with aseptic nipper, is attached to plate containing bacterium
On, using the filter paper that sterile water impregnates as blank control, Micro-Organism Culture Dish is placed in plate in 37 DEG C of constant incubators and is inverted
Yeast and mold culture dish for 24 hours, is placed in plate in 28 DEG C of constant incubators and is inverted 72~120h of culture, measured antibacterial by culture
The size of loop diameter, if 3 repetitions, take its average value.
3. result and analysis
Table 1 is the fungistatic effect experimental result of Examples 1 to 4 preservative.
1 fungistatic effect experimental result of table
It can show that 4 groups of preservatives of Examples 1 to 4 have antiseptic and inhibiting bacteria function effect to five kinds of microorganisms by table 1, inhibition zone is straight
Diameter is all larger than 10mm, acts on more apparent, the biocidal property with wide spectrum, wherein best with preservative effectiveness made from embodiment 2.It is comprehensive
For conjunction, bacteriostasis size of the Examples 1 to 4 group preservative to five kinds of bacterium are as follows: Escherichia coli > pseudomonas aeruginosa > yeast
Bacterium > staphylococcus aureus > aspergillus niger.
Effect example 2: preservation challenge test
By 4 groups of aseptic applications of Examples 1 to 4 in face cleaning cream, 2% Examples 1 to 4 is added into system respectively
Preservative, carry out preservation challenge test.
1. material
1.1 test material
It joined 4 groups of face cleaning cream of the preservative that Examples 1 to 4 is prepared.
1.2 tested strains
Bacterium: staphylococcus aureus, Escherichia coli, pseudomonas aeruginosa.
Mould and saccharomycete: saccharomyces cerevisiae, aspergillus niger.
1.3 for trying culture medium
Bacteria culture media: nutrient agar, it is spare after 121 DEG C of high pressure sterilization 30min.
Microzyme culture medium: YPD culture medium, it is spare after 115 DEG C of high pressure sterilization 30min.
Mould medium: Czapek's medium, it is spare after 115 DEG C of high pressure sterilization 30min.
2. experimental method
The preparation of 2.1 bacteria suspensions
Each bacterial strain is inoculated into corresponding medium slant respectively before experiment.Bacterium (staphylococcus aureus, large intestine bar
Bacterium, pseudomonas aeruginosa) it is cultivated 36~48 hours in 36 ± 1 DEG C of constant incubators, appropriate bacterium colony is picked them separately in sterile
It is mixed in physiological saline, certain density plastc ring is made, mixed cell suspension total concentration is about 1.0 × 108CFU/ml,
It is spare to be placed in 4 DEG C of storages.Mould is cultivated 120 hours in 27 ± 1 DEG C of constant incubators, 27 ± 1 DEG C of constant incubators of saccharomycete
Middle culture 24 hours picks them separately appropriate yeast and mold bacterium colony and is uniformly mixed in sterile saline, is made certain dense
The fungi plastc ring of degree, mixing yeast and mold spore suspension total concentration is about 1.0 × 107CFU/ml is placed in 4 DEG C of storages
It deposits spare.
The experiment of 2.2 preservation challenges
Using primary plus bacterium 28 days Microbial Challenges test, this method is tested referring to United States Pharmacopeia Microbial Challenge
The method for detecting preservative effectiveness.4 groups of face cleaning cream sample 100g are weighed respectively to be packed into sample bottle as test sample, then are divided
Suitable plastc ring is not added, every gram of sample is made finally to contain amount of bacteria 106CFU/g, mould yeast bacterium amount are 105CFU/
G is mixed well, and is respectively placed in 36 ± 1 DEG C and 27 ± 1 DEG C of constant incubators and is cultivated.Inoculation the 0th day, the 3rd day, the 7th day,
Sampling in 14th day, the 21st day and the 28th day carries out bacterium amount analysis.
3. evaluation criterion
Initial inoculum: bacterium 106CFU/g~107CFU/g (mL), fungi 105CFU/g~106CFU/g (mL):
1. at the 28th day, bacterium or fungus G T.GT.GT 10 are contained in sample3CFU/g (mL), the sample cannot pass through microorganism attack
Challenge test, show the protective system of sample cannot effectively act as inhibit microorganism effect, product production, storage and
The pollution of microorganism is highly susceptible in use.
2. at the 28th day, containing bacterium or fungi 10 in sample2CFU/g~103CFU/g (mL), the sample conditionally lead to
Cross challenge test, i.e., when protein in product or other animals and plants material compositions are not especially high, while the hygienic conditions produced
It meets the requirements, when packing material is not susceptible to secondary pollution, which be can be used, and otherwise cannot.
3. at the 28th day, containing bacterium or fungi in 10CFU/g~10 in sample2CFU/g (mL), shows the anti-corrosion of the sample
System to microorganism have it is stronger suppression kill effect, by challenge test, product production, storage and using when be not readily susceptible to it is micro-
Biological pollution.
4. from the 7th day, bacterium or fungi < 10CFU/g (mL) in sample illustrated the protective system of the sample to micro-
Biology has the inhibitory or killing effect of extra-heavy, by challenge test, product production, storage and using when be not easy very much by microorganism dirt
Dye.
3. result and analysis
If the following table 2 is the preservation challenge experiment knot that joined 4 groups of face cleaning cream of the preservative that Examples 1 to 4 is prepared
Fruit.
2 preservation challenge experimental result of table
Table 2 the result shows that: at the 28th day, bacterium in all samples, yeast and mold the equal < 10CFU/g of content
(mL), show that Examples 1 to 4 group preservative has stronger suppression to kill effect several microorganisms, tested by challenge, product exists
Production, storage and using when be not readily susceptible to microbial contamination.Four kinds of preservatives of Examples 1 to 4 can be used as face cleaning cream
Protective system substitutes traditional chemical synthetic preservative, safer, mild product is provided for consumer.
Application examples 1 and application examples 2:
Application based on the cosmetics preservative of natural plant composition in face cleaning cream prepared by embodiment 1, it is described clean
Face cream includes following mass parts raw material, is specifically shown in Table 3.
3 face cleaning paste formulation example of table
Application examples 3 and application examples 4:
Application based on the cosmetics preservative of natural plant composition in face cream prepared by embodiment 2, the shield
Skin frost includes following mass parts raw material, is specifically shown in Table 4.
4 prescription for skin cream example of table
| Raw material | Application examples 3 (mass parts) | Application examples 4 (mass parts) |
| Rice bran oil | 6.0 | 2.0 |
| Jojoba oil | 2.0 | 4.0 |
| Hexadecanol | 2.0 | 1.0 |
| Glycerin monostearate | 0.8 | 1.5 |
| Glycerol | 7.0 | 4.0 |
| 1,2-PD | 4.0 | 7.0 |
| Odium stearate | 1.5 | 1.0 |
| Cetostearyl alcohol pentoside | 0.4 | 1.0 |
| Preservative prepared by embodiment 2 | 3.0 | 1.0 |
| Water | 73.3 | 77.5 |
Effect example 3: quality testing
Table 5 is the micro-biology experiment testing result of product obtained by application examples 1~4.
5 application examples of table, 1~4 microbial indicators detected result
Microbial indicators detected method is carried out according to " cosmetics safety technical specification " (version in 2015).Use above example 1
The microbiological indicator of face cream product obtained by face cleaning cream product and application examples 3~4 obtained by~2 meets " cosmetics
Technical specification of security " to the index request of microorganism.
The above description is merely a specific embodiment, it is noted that it is existing skill that remaining, which is not described in detail,
Art, within the technical scope disclosed by the invention, any changes or substitutions that can be easily thought of for anyone skilled in the art,
It should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of cosmetics preservative based on natural plant composition, which is characterized in that the preservative presses quality by the following raw material
Part compounds: 20~30 parts of litsea cubeba oil, 5~15 parts of oldenlandia diffusa extracting solution, 60~70 parts of dihydric alcohol mixed liquor.
2. the cosmetics preservative according to claim 1 based on natural plant composition, which is characterized in that the preservative by
The following raw material is compounded by mass parts: 22~28 parts of litsea cubeba oil, 7~12 parts of oldenlandia diffusa extracting solution, dihydric alcohol are mixed
Close 62~68 parts of liquid.
3. the cosmetics preservative according to claim 1 based on natural plant composition, which is characterized in that the preservative by
The following raw material is compounded by mass parts: 25~26 parts of litsea cubeba oil, 10~12 parts of oldenlandia diffusa extracting solution, dihydric alcohol are mixed
Close 64~65 parts of liquid.
4. the cosmetics preservative according to claim 1 or 2 or 3 based on natural plant composition, which is characterized in that described
For dihydric alcohol mixed liquor by 1,2- pentanediol and 1,2- hexylene glycol is that 2~4:1 is mixed in mass ratio.
5. the cosmetics preservative according to claim 1 or 2 or 3 based on natural plant composition, which is characterized in that described
Litsea cubeba oil is prepared by the following method:
1) fruit of a cubeb litsea tree fresh fruit is subjected to 1~2min of broken wall treatment, obtains the slurry of fruit of a cubeb litsea tree fresh fruit；
It 2) is in mass ratio that 1:2~5 mix with distilled water by the resulting slurry of step 1), the oil bath for being 120~130 DEG C in temperature
It is middle that 2~3h is distilled using steam distillation, upper oil phase is collected to get litsea cubeba oil is arrived.
6. the cosmetics preservative according to claim 1 or 2 or 3 based on natural plant composition, which is characterized in that described
Oldenlandia diffusa extracting solution is prepared by the following method:
1) oldenlandia diffusa complete stool is passed through into clean, drying and pulverization process, then is divided with lower part of screen after 40~60 mesh sieves
Obtain Spreading Hedyotis Herb；
It 2) is that 1:4~5 mix by solid-liquid mass ratio with dihydric alcohol mixed liquor by the resulting Spreading Hedyotis Herb of step 1), in temperature
Degree is 1~2h of mechanical shaking extraction under conditions of 90~100 DEG C, is filtered while hot with 100~200 meshes, obtains filtrate；
3) 20~30min is centrifuged after being cooled to room temperature the resulting filtrate of step 2) at 4000~4500rpm, supernatant is taken to pass through
Active carbon decoloring processing is crossed to get oldenlandia diffusa extracting solution.
7. the cosmetics preservative according to claim 6 based on natural plant composition, which is characterized in that the step 1)
For middle dihydric alcohol mixed liquor by 1,2- pentanediol and 1,2- hexylene glycol is that 2~4:1 is mixed in mass ratio.
8. a kind of application of the cosmetics preservative described in claims 1 or 2 or 3 based on natural plant composition, feature exist
In the cosmetics preservative based on natural plant composition makes an addition in cosmetics, and quality dosage is 1~3%.
9. the application of the cosmetics preservative according to claim 8 based on natural plant composition, which is characterized in that described
Application based on the cosmetics preservative of natural plant composition in face cleaning cream, the face cleaning cream by following mass parts raw material group
At: 10.0~14.0 parts of stearic acid, 12.0~16.0 parts of myristic acid, 3.0~7.0 parts of lauric acid, jojoba oil 2.0~4.0
Part, 13.0~17.0 parts of sorbierite, 8.0~13.0 parts of glycerol, 8.0~12.0 parts of 1,3-BDO, PEG-20 stearate 1.0
~3.0 parts, 3.0~6.0 parts of N- acyl-N-methyl sodium taurocholate, 0.15~0.3 part of EDETATE SODIUM, potassium hydroxide 4.0~6.9
Part and 2.0~3.0 parts of cosmetics preservative based on natural plant composition as described in claims 1 or 2 or 3, surplus are
Water, the sum of mass fraction of each raw material are 100 parts.
10. the application of the cosmetics preservative according to claim 8 based on natural plant composition, which is characterized in that institute
State application of the cosmetics preservative based on natural plant composition in face cream, the face cream by following mass parts raw material
Composition: 2.0~6.0 parts of rice bran oil, 2.0~4.0 parts of jojoba oil, 1.0~2.0 parts of hexadecanol, glycerin monostearate 0.8~
1.5 parts, 4.0~7.0 parts of glycerol, 4.0~7.0 parts of 1,2-PD, 1.0~1.5 parts of odium stearate, cetostearyl alcohol pentoside
0.4~1.0 part and the cosmetics preservative 1.0~3.0 based on natural plant composition as described in claims 1 or 2 or 3
Part, surplus is water, and the sum of mass fraction of each raw material is 100 parts.
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| CN109966223A (en) * | 2019-04-29 | 2019-07-05 | 华南协同创新研究院 | A kind of natural plant source antiseptic agent and its preparation method and application |
| CN110257470A (en) * | 2019-05-28 | 2019-09-20 | 中科萱嘉医养(珠海)健康科技有限公司 | A kind of method of quick judgement plant antiseptic agent KM antiseptic effect |
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| CN109966223B (en) * | 2019-04-29 | 2021-11-02 | 华南协同创新研究院 | Natural plant-derived preservative and preparation method and application thereof |
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