CN102000108A - Gynaecological medicine composition as well as external-use capsule and application thereof - Google Patents
Gynaecological medicine composition as well as external-use capsule and application thereof Download PDFInfo
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Abstract
The invention relates to a gynaecological medicine composition as well as an external-use capsule and application thereof. The gynaecological medicine composition mainly comprises the following components in 1000 parts by weight: 2-20 parts of polyhexamethylene guanidine (PHGM), 1-30 parts of water and the balance of glycerol. The gynaecological external-use capsule comprises medical soft capsule and a medicine composition contained in the medical soft capsule, wherein the medicine composition comprises the following components in parts by weight: 2-20 parts of polyhexamethylene guanidine (PHGM), 1-30 parts of water and the balance of glycerol. The gynaecological medicine composition can be used for preparing antibacterial and antiphlogistic medicines for treating gynaecological diseases. The gynaecological external-use capsule has wide effects of resisting bacteria, thoroughly killing various bacterial viruses, eliminating inflammations and treating the gynaecological diseases; the gynaecological external-use capsule has good moisturizing effect, has the functions of keeping female skin soft, delaying and resisting skin aging and restoring damaged skin, and has no toxic and side effect.
Description
Technical field
The invention belongs to pharmaceutical field, be specifically related to a kind of gynecologic medicine compositions and external-applied capsules and preparation method, simultaneously, also relate to the application of gynecologic medicine compositions in the medicine of preparation treatment gynaecopathia.
Background technology
We lead to gelatine capsule commonly now, and composition is a gelatin.Pharmagel is to select animal skins, bone and muscle tendon for use, handles the senior glue product that the fat-free high protein that makes easily is absorbed by the body through the physics and chemistry of complexity.Have the viscosity height, freeze the power height, physical characteristics such as easily congeal.Usually capsule is divided into hard capsule and soft capsule.
Hard capsule is that a certain amount of medicine (or medicinal substances extract) and suitable adjuvant (also can not add adjuvant) are made uniform powder or granule, loads in hollow hard capsules and makes.
Soft capsule is that a certain amount of medicine (or medicinal substances extract) is dissolved in the suitable adjuvant, and reuse pressing (or dropping preparation method) makes it to be sealed in spherical or the olivary soft capsule.
At present, female vagina, cervicitis, adnexitis etc. is the common and multiple disease of middle aged and aged women, directly influences women's body and mind Jiankang and love life, also can influence U.S. face, causes occurring too early aging.The capsule of these diseases of traditional treatment can be oral capsule and external-applied capsules again, oral medicine, dose is little, absorbtivity is little, effect takes effect slowly, treatment time is long, and existing Amino-Cerv beyond the region of objective existence mostly is hard capsule with capsule, the water soluble preparation that adopts Chinese medicine extract makes in the middle of the hard capsules of packing into after the pulverizing through super-dry mostly, and the Chinese crude drug cost is higher, valuable Chinese crude drug costs an arm and a leg especially, and medicine refining work complexity, hard capsule are filled in just dissolving after a very long time behind the pudendum, and be very uncomfortable after the use.Chinese invention patent prospectus on October 12nd, 2005 disclosed (publication number CN 1679687A) " a kind of treatment gynaecopathia external-applied capsules and preparation method thereof " discloses the external-applied capsules that a kind of gynecological uses, and belonging to its interior medicine is powdered hard capsule.
Can fill various oils in the soft capsule or gelatin not had the liquid medicine or the suspension of dissolution, usually medicine may absorb water, tend to cause that moisture changes in the soft balsam softgel shell, if medicine is hydrophilic, should make medicine keep 5% water, oils is generally as the solvent of medicine or the medium of suspension, though the soft capsule of extending oil does not have moisture, the moisture in dampness or the capsule shells can see through cyst wall and enter wherein.If medicine is hydrophilic, also should keep 3% moisture.Soft capsule contains moisture and surpasses 50% or contain low-molecular-weight and mutual miscible volatile solvent such as ethanol, acetone, amine, acid and the esters etc. of water in inner medicinal liquid, all can make the softening or dissolving of soft capsule shell, and the Chinese medicine medicinal liquid can only be a water liquid medicine because of the extraction process decision, therefore should not make soft capsule with traditional Chinese medicine liquid.
Known guanidine family macromolecule is the good sterilization agent, and polyhexamethylene guanidine (PHMG) is a kind of colourless or light yellow transparent liquid, and is tasteless, soluble in water, in industry, agricultural and daily life extremely extensive use is arranged, and raw material sources are extensive.
Glycerol is the thick liquid of a kind of colourless, odorless, sweet in the mouth, also is good organic solvent, and soluble in water, it is nonpoisonous and tasteless nuisanceless, is used for cosmetics industry in a large number, food industry, water-based printing ink, coatings industry etc.
Be used for anti-inflammation in the prior art, the medicine of treatment gynaecopathia can soften or dissolving by soft capsule shell, and the capsule instability is easily broken, effective time is short, all is not suitable for making soft capsule, based on the prior art reason, the present domestic anti-inflammation that also is not used in, the soft capsule of treatment gynaecopathia.
Summary of the invention
The purpose of this invention is to provide a kind of external soft capsule of can be made into, can be used for anti-inflammation, the gynecologic medicine compositions and the external-applied capsules of treatment gynaecopathia, the application of gynecologic medicine compositions in the medicine of preparation treatment gynaecopathia is provided simultaneously, has the various bacteria of killing simultaneously, diminish inflammation treatment gynaecopathia, the effect of repairing impaired skin.
Following all components all calculate with 1000 parts of measurement units.
The present invention is achieved in that a kind of gynecologic medicine compositions, mainly comprises following components in portion by weight:
Polyhexamethylene guanidine (PHMG): 2～20 parts;
Water: 1～30 part;
Glycerol: surplus.
Further, described gynecologic medicine compositions, wherein the weight proportion of component is:
Polyhexamethylene guanidine (PHMG): 5～10 parts;
Water: 1～30 part;
Glycerol: surplus.
Find when the weight proportion of polyhexamethylene list guanidine in the pharmaceutical composition surpasses 10 parts, sticking to mould in the pudendum is had certain stimulation after deliberation, weight proportion reaches maximum use amount when being 20 parts, and the preferred weight proportion of gynecologic medicine compositions is:
Polyhexamethylene guanidine (PHMG): 5 parts;
Water: 20 parts;
Glycerol: surplus.
A kind of gynecological external use capsule that utilizes above-mentioned gynecologic medicine compositions to make comprises medicinal soft capsule and is contained in its interior pharmaceutical composition, and the component weight proportion of described pharmaceutical composition is:
Polyhexamethylene guanidine (PHMG): 2～20 parts;
Water: 1～30 part;
Glycerol: surplus.
Further, described gynecological external use capsule, the component weight proportion of the pharmaceutical composition in it is:
Polyhexamethylene guanidine (PHMG): 5～10 parts;
Water: 1～30 part;
Glycerol: surplus.
Best, described gynecological external use capsule, the component weight proportion of the pharmaceutical composition in it is:
Polyhexamethylene guanidine (PHMG): 5 parts;
Water: 20 parts;
Glycerol: surplus.
The preparation method of described gynecological external use capsule is: polyhexamethylene list guanidine is dissolved in the water, join after the dissolving in the glycerol of surplus and be made into pharmaceutical composition solution, mix the back evenly, pharmaceutical composition solution is enclosed soft capsule make product.
Described gynecologic medicine compositions can be at the preparation anti-inflammation, the application in the medicine of treatment gynaecopathia.
Soft capsule of the present invention has good effect, and instant effect is antibiotic extensive, can thoroughly kill various bacterial viruses, diminishes inflammation treatment gynaecopathia effect; Employing glycerol is excipient substance, also has good moisture retention effect simultaneously, can keep cloudy interior skin softness, prolongs anti-skin aging, repairs the effect of impaired skin; Raw material sources are extensive, no side effects, and cost is low.
The specific embodiment
Embodiment 1
Get the polyhexamethylene guanidine (PHMG) of 2 parts of weight proportions and 20 parts water dissolution, join in 500 parts the glycerol and mix, add glycerol again and be mixed with the gross weight reprovision than the pharmaceutical composition solution that is 1000 parts, fully mix, left standstill 2 hours, and pharmaceutical composition solution was enclosed soft capsule make product.
Embodiment 2
Get the salt hexa-methylene guanidine (PHMG) of 5 parts of weight proportions and 20 parts water dissolution, join in 500 parts the glycerol and mix, add glycerol again and be mixed with the gross weight reprovision than the pharmaceutical composition solution that is 1000 parts, fully mix, left standstill 2 hours, and pharmaceutical composition solution was enclosed soft capsule make product.
Embodiment 3
Get the polyhexamethylene guanidine (PHMG) of 10 parts of weight proportions and 20 parts water dissolution, join in 500 parts the glycerol and mix, add glycerol again and be mixed with the gross weight reprovision than the pharmaceutical composition solution that is 1000 parts, fully mix, left standstill 2 hours, and pharmaceutical composition solution was enclosed soft capsule make product.
Embodiment 4
Get the polyhexamethylene guanidine (PHMG) of 20 parts of weight proportions and 30 parts water dissolution, join in 500 parts the glycerol and mix, add glycerol again and be mixed with the gross weight reprovision than the pharmaceutical composition solution that is 1000 parts, fully mix, left standstill 2 hours, and pharmaceutical composition solution was enclosed soft capsule make product.
Experimental example
Get the polyhexamethylene list guanidine (PHMG) of 5 parts of weight proportions and 20 parts water dissolution, join in 500 parts the glycerol and mix, add glycerol again and be mixed with the gross weight reprovision than the pharmaceutical composition solution that is 1000 parts, fully mix, left standstill 2 hours, and got the pharmaceutical composition solution for preparing as laboratory sample.
Sample is to skin, and mucosa and eye carry out repeatedly irritant test, and the result does not irritate for all having.
Sample is carried out the antibiotic and sterilizing experiment, and the foundation of experiment is the version-2.1.11.3.1 requirement in 2002 of " disinfection technology standard " Ministry of Public Health, respectively killing of following virus and bacteria is experimentized:
1, experimental strain: candida albicans
Killing rate: 99.8%
Experimental result such as following table:
2, experimental strain: escherichia coli
Killing rate: 99.98%
Experimental result such as following table:
3, experimental strain: staphylococcus aureus
Killing rate: 99.89%
Experimental result such as following table:
4, experimental strain: bacillus pyocyaneus
Killing rate: 99.99%
Experimental result such as following table:
By this experimental example as seen, pharmaceutical composition solution of the present invention can be killed various bacteria virus, and bacterial inactivation rate can reach 100% basically, can effectively kill various bacteria virus, thereby reach anti-inflammation, the effect of treatment gynaecopathia, evident in efficacy.
Gynecological external use capsule of the present invention is easy to use, and is comfortable; Raw material sources are extensive, no side effects, and cost is low, and processing technology is simple; Glycerol has good moisture retention effect simultaneously, can keep cloudy interior skin softness, prolongs anti-skin aging, repairs the effect of impaired skin; Antibiotic extensive and effective extremely, instant effect, useful effects such as treatment time weak point.
Claims (10)
1. a gynecologic medicine compositions is calculated with 1000 parts of measurement units, and it comprises following components in portion by weight:
Polyhexamethylene guanidine: 2～20 parts;
Water: 1～30 part;
Glycerol: surplus.
2. gynecologic medicine compositions according to claim 1, component weight proportion wherein:
Polyhexamethylene guanidine (PHMG): 2～20 parts;
Water: 1～30 part;
Glycerol: surplus.
3. gynecologic medicine compositions according to claim 2, component weight proportion wherein is:
Polyhexamethylene guanidine (PHMG): 5～10 parts;
Water: 1～30 part;
Glycerol: surplus.
4. gynecologic medicine compositions according to claim 3, component weight proportion wherein is:
Polyhexamethylene guanidine (PHMG): 5 parts;
Water: 20 parts;
Glycerol: surplus.
5. a gynecological external use capsule comprises medicinal soft capsule and is contained in its interior pharmaceutical composition, and the component weight proportion of described pharmaceutical composition is the arbitrary described composition weight proportioning of claim 1-4.
6. the preparation method of a gynecological external use capsule as claimed in claim 5, comprise the steps: the polyhexamethylene guanidine (PHMG) of 2 parts of weight is dissolved in 20 parts of water, join the pharmaceutical composition solution that is made into 1000 parts of weight in the glycerol of surplus after the dissolving, mix the back evenly, drug solution is enclosed soft capsule make product.
7. the preparation method of a gynecological external use capsule as claimed in claim 5, comprise the steps: the polyhexamethylene guanidine (PHMG) of 5 parts of weight is dissolved in 20 parts of water, join the pharmaceutical composition solution that is made into 1000 parts of weight in the glycerol of surplus after the dissolving, mix the back evenly, drug solution is enclosed soft capsule make product.
8. the preparation method of a gynecological external use capsule as claimed in claim 5, comprise the steps: the polyhexamethylene guanidine (PHMG) of 10 parts of weight is dissolved in 20 parts of water, join the pharmaceutical composition solution that is made into 1000 parts of weight in the glycerol of surplus after the dissolving, mix the back evenly, drug solution is enclosed soft capsule make product.
9. the preparation method of a gynecological external use capsule as claimed in claim 5, comprise the steps: the polyhexamethylene guanidine (PHMG) of 20 parts of weight is dissolved in 30 parts of water, join the pharmaceutical composition solution that is made into 1000 parts of weight in the glycerol of surplus after the dissolving, mix the back evenly, drug solution is enclosed soft capsule make product.
10. the arbitrary described pharmaceutical composition of claim 1-2 is preparing anti-inflammation, the application in the medicine of treatment gynaecopathia.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010528154 CN102000108A (en) | 2010-11-01 | 2010-11-01 | Gynaecological medicine composition as well as external-use capsule and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010528154 CN102000108A (en) | 2010-11-01 | 2010-11-01 | Gynaecological medicine composition as well as external-use capsule and application thereof |
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| CN102000108A true CN102000108A (en) | 2011-04-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705536A (en) * | 2014-01-03 | 2014-04-09 | 卫望奎 | Pharmaceutical formula of polyhexamethylene guanidine hydrochloride (PHMG) and preparation method |
| CN104586767A (en) * | 2014-12-31 | 2015-05-06 | 卫国刚 | Polyhexamethylene guanidine oral spray |
| CN105727016A (en) * | 2016-02-25 | 2016-07-06 | 史春艳 | Gynecological medicament for vulva cleaning and a preparation method thereof |
| CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099615A (en) * | 1993-08-30 | 1995-03-08 | 锦州制药二厂闾山分厂 | Dithiazole ointment and preparing method |
| CN1927370A (en) * | 2006-08-25 | 2007-03-14 | 张彤丽 | Baofukang vaginal soft capsule and its preparing process |
-
2010
- 2010-11-01 CN CN 201010528154 patent/CN102000108A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1099615A (en) * | 1993-08-30 | 1995-03-08 | 锦州制药二厂闾山分厂 | Dithiazole ointment and preparing method |
| CN1927370A (en) * | 2006-08-25 | 2007-03-14 | 张彤丽 | Baofukang vaginal soft capsule and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| 《中国消毒学杂志》 20070131 王建红等 妇科洗液抑菌效果观察 76 1-4，10 第24卷, 第1期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103705536A (en) * | 2014-01-03 | 2014-04-09 | 卫望奎 | Pharmaceutical formula of polyhexamethylene guanidine hydrochloride (PHMG) and preparation method |
| CN104586767A (en) * | 2014-12-31 | 2015-05-06 | 卫国刚 | Polyhexamethylene guanidine oral spray |
| CN105727016A (en) * | 2016-02-25 | 2016-07-06 | 史春艳 | Gynecological medicament for vulva cleaning and a preparation method thereof |
| CN111939172A (en) * | 2020-03-06 | 2020-11-17 | 吉林云飞医药有限公司 | Disinfectant for women and preparation method thereof |
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