CN106214926A - A kind of nasal spray and preparation method thereof - Google Patents
A kind of nasal spray and preparation method thereof Download PDFInfo
- Publication number
- CN106214926A CN106214926A CN201610614841.0A CN201610614841A CN106214926A CN 106214926 A CN106214926 A CN 106214926A CN 201610614841 A CN201610614841 A CN 201610614841A CN 106214926 A CN106214926 A CN 106214926A
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- China
- Prior art keywords
- nasal spray
- acid
- weight portion
- parts
- juice
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Abstract
The invention belongs to pharmaceutical arts, it is specially a kind of nasal spray and preparation method thereof, wherein nasal spray includes each material of following weight portion: poly hexamethylene biguanide 1 30 parts, normal saline 90 210 parts, wetting agent 12 51 parts, natural organic acids 3 17 parts, 14 26 parts of Bulbus Allii juice, seed oil of Moringa oleigera 5 15 parts, Oleum menthae 13 parts, 16 30 parts of Herba Asparagi Setacei juice.Described natural organic acids is to contain and extractible acid in natural plant.It is by cleaning nostril and being formed in nostril and have the sterilization system of long-term bactericidal effect, it is achieved avoid infecting respiratory tract disease under haze weather or alleviating the respiratory disease patient state of an illness under haze weather.
Description
Technical field
The invention belongs to pharmaceutical arts, be specially a kind of nasal spray and preparation method thereof.
Background technology
Along with industrial expansion, haze is increasingly severe.On January 4th, 2014, country includes haze weather in 2013 first
Year, natural the condition of a disaster was circulated a notice of.Haze seems gentle, and various harmful fine grained is but contained in the inside, noxious substance reaches 20
Multiple, including acid, alkali, salt, amine, phenol etc., and dust, pollen, acarid, influenza virus, tubercule bacillus, streptococcus pneumoniae etc., and
And its content is tens times of normal atmospheric water droplet.These harmful substances contained in haze once enter respiratory tract, can adhere
On alveolar, the most then can cause the nose diseasess such as rhinitis, heavy then pulmonary can be caused to harden, even it is also possible to cause pulmonary carcinoma.Cause
This, for chronic respiratory system diseases such as bronchial asthma, chronic bronchitis, obstructive emphysema and chronic obstructive pulmonary disease
Patient, haze weather can make state of an illness acute attack or acute exacerbation.Meanwhile, haze weather also can cause many new people
Group suffers from respiratory tract disease.
And prior art is mainly based on treatment when treating the respiratory tract disease that haze causes, but fail from root
Solve after people's incoming call haze antibacterial hypertrophy incoming respiratory system and then diseases induced problem in nostril.
All in the compound of disinfection, human influence's minimum is mainly polyhexamethylene guanidine
(PHMG).Polyhexamethylene guanidine is a kind of novel polymeric cationic compound, positively charged after being dissolved in water, it is possible to penetrate into micro-life
In object, and it is readily adsorbed in electronegative antimicrobial surface, destroys the cellularity of microbial body, thus play sterilization
The effect of sterilizing.Its biguanide structure is similar with other biguanides antibacterial, but has the highest molecular weight and the degree of polymerization, safety
High.At present, not yet having the correlational study being applied to nasal spray, main reason is that: one is relatively costly, two is its sterilization
Effect is too strong can be destroyed the original microbe colony of nasal cavity and then cause other series of disease.
Summary of the invention
Increase and the most serious the asking of respiratory system disease to solve respiratory system disease patient populations under haze weather
Topic, the present invention provides a kind of nasal spray and preparation method thereof, and it is by cleaning nostril and being formed to have in nostril and kill for a long time
The sterilization system of bacterium effect, it is achieved avoid infecting respiratory tract disease under haze weather or alleviating respiratory disease patient at haze
The state of an illness under weather.
In order to solve above-mentioned technical problem, the concrete technical scheme that the present invention takes is, a kind of nasal spray, including such as
Each material of lower weight portion:
Described natural organic acids is to contain and extractible acid in natural plant.
The technical scheme improved as the present invention, described wetting agent is glucose, nature moisturizing factor or hydrophile amino
Acid.
The technical scheme improved as the present invention, including each material of following weight portion:
As further improved technical scheme of the present invention, also including slow releasing agent, its weight portion is 11-35 part, described slow
Releasing agent is acrylate polymer, poly butyric ester or chitosan.
The technical scheme improved as the present invention, including each material of following weight portion:
The technical scheme improved as the present invention, also includes slow releasing agent, and its weight portion is 5-15 part, and described slow releasing agent is third
Olefine acid ester polymer, poly butyric ester or chitosan.
The technical scheme improved as the present invention, also includes Sargassum polysaccharides, and its weight portion is 23-36 part.
The technical scheme improved as the present invention, described natural organic acids is preferably: salicylic acid, malic acid, tartaric acid, lemon
Two kinds of a kind of or any mass ratio in lemon acid, mandelic acid, Fructus Vitis viniferae acid, citric acid or lactic acid.
The technical scheme improved as the present invention, also includes stabilizer, and the weight portion of stabilizer is 1-5 part, described stable
Agent is pectin.
The present invention also provides for the preparation method of a kind of nasal spray, including: Herba Asparagi Setacei is mixed in water and decocts into juice, then press
According to setting weight part ratio by poly hexamethylene biguanide, normal saline, wetting agent, natural organic acids, Bulbus Allii juice, seed oil of Moringa oleigera, thin
Lotus oil and Herba Asparagi Setacei juice are mixed.
Beneficial effect
Using nasal spray of the present invention under haze weather is a large amount of solid particles contained in the gas removing incoming call
Thing and microbial bacterial etc. are main, are auxiliary to treat the state of an illness of respiratory disease patient.The formula of the present invention is by anti-microbial property, nose
Chamber immunity performance and flushing action are combined as a whole, and use the nasal spray of the present invention, and one is can to realize rushing nasal cavity
Wash；Two is to have rinsed rear nasal spray to have good biocompatibility, anti-microbial property nasal cavity formation one layer, and can inhale
Attached metal ion or the protecting film of metal micro particles；Three is to repeat to spray nasal spray, and nasal spray can remove original protecting film also
Form new protecting film；Four be protecting film be water solublity, can use clear water wash except nasal cavity residual nasal spray composition.
Detailed description of the invention
Purpose and technical scheme for making the embodiment of the present invention are clearer, below the technical scheme to the embodiment of the present invention
It is clearly and completely described.Obviously, described embodiment is a part of embodiment of the present invention rather than whole realities
Execute example.Based on described embodiments of the invention, those of ordinary skill in the art are institute on the premise of without creative work
The every other embodiment obtained, broadly falls into the scope of protection of the invention.
Embodiment 1
A kind of nasal spray, including each material of following weight portion:
Herba Asparagi Setacei is first mixed in water and decocts into juice by the preparation method of above-mentioned nasal spray, then according to setting weight part ratio
Poly hexamethylene biguanide, normal saline, wetting agent, natural organic acids, Bulbus Allii juice, seed oil of Moringa oleigera, Oleum menthae and Herba Asparagi Setacei juice are mixed
Make.
Embodiment 2
A kind of nasal spray, including each material of following weight portion:
Embodiment 3
A kind of nasal spray, including each material of following weight portion:
Embodiment 4
A kind of nasal spray, including each material of following weight portion:
Embodiment 5
A kind of nasal spray, including each material of following weight portion:
Embodiment 6
A kind of nasal spray, including each material of following weight portion:
Embodiment 7
A kind of nasal spray, including each material of following weight portion:
Embodiment 8
A kind of nasal spray, including each material of following weight portion:
Embodiment 9
A kind of nasal spray, including each material of following weight portion:
Implementation result
Both having contained poly hexamethylene biguanide (it is with-NH2 functional group) in formula, the natural organic acids contained again, at nose
In spray, poly hexamethylene biguanide, natural organic acids can individually play antibacterial action, it is possible under the catalytic action of haze,
In poly hexamethylene biguanide ,-NH2 and natural organic acids react and generate the material of bigger molecular weight, and the thing of macromolecule
Particulate matter parcel in haze also can be formed macromole film at nasal cavity by matter, and macromole film is at the common work with other compositions
Can effectively absorb in haze particulate matter under with and realize sterilizing function.
Bulbus Allii juice and seed oil of Moringa oleigera in formula not only have bactericidal action, effect the most excitatory, can stimulate nasal mucosa,
Make nasal cavity secreting liquid so that the impurity antibacterial etc. sticking to nasal cavity is flowed out with liquid.But in order to avoid excessive
Stimulating the protective effect destroying nasal mucosa, add a certain amount of Oleum menthae and Herba Asparagi Setacei juice, Oleum menthae is refrigerant, and Herba Asparagi Setacei juice abnormal smells from the patient is clear
Perfume (or spice), can protect nasal mucosa to be destroyed by physical property, and Herba Asparagi Setacei juice is to anthrax bacillus, A type and beta hemolytic streptococcus, white
Larynx bacillus, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and hay
Bacillus all has bacteriostasis in various degree.
Performance test
(1) formulation stable performance test
It is attached separately to after the formula constituent mix homogeneously of embodiment 1-9 in 1-9 Clear glass bottles and jars, and by 1-9 glass
Glass bottle carries out high temperature, high light and high humidity performance test respectively, and samples in different time spacer segment,
High temperature test: by nasal spray in the calorstat that temperature is 50 DEG C, places 10 days, and respectively 5 days, 10 days, 30
My god, 90 days sampling and measuring；
High optical tests: nasal spray is placed in lower 10 days of the photoenvironment that illumination is 4500 ± 500LX, and respectively 5 days, 10
My god, 30 days, 90 days sampling and measuring；
High humidity is tested: be placed in by nasal spray in the high humidity experimental box that humidity is 92.5% 10 days, and respectively 5 days, 10 days,
30 days, 90 days sampling and measuring.
Institute's test result see table 1.
Table 1 embodiment 1-9 formulation stable performance is tested
Experimental result is as described in Table 1, and the nasal spray of the present invention is temperature sensitive, answers room temperature or cryopreservation.
(2) nasal spray of the present invention dynamically change test
After utilizing Malvern real-time granularity of spray analyser Spraytec to measure nasal spray spraying, droplet dynamically changed
Journey, analyzes the diameter (using the injection of manual trigger-type at shower nozzle distance laser optical path 5cm) of spraying droplet.Result shows
Show, spraying droplet volume average particle size 49.1 μm that Dv (10) 38.17 μm, Dv (50) 56.41 μm, Dv (90) 72 μm are not below
Droplet below 20 μm exists, and the droplet of nasal spray will not enter lower respiratory tract and pulmonary.
(3) using effect test
Embodiment, randomly selects equal extent chronic rhinitis patient 360, is divided into 9 groups by 40 chronic rhinitis patients,
9 groups of personnel being carried out nasal cavity cleaning, sprays the nasal spray of embodiment 1-9 after having cleaned respectively, under haze weather, activity 5 is little
Time, and continue one week, use the personnel of embodiment 1,2 formula to have 2 chronic rhinitis patient's rhinitis recurrences, use embodiment 3-9
Personnel's unmanned recurrence rhinitis of formula and Rhinitis Symptoms alleviated.
These are only embodiments of the present invention, it describes more concrete and in detail, but can not therefore and be interpreted as right
The restriction of the scope of the claims of the present invention.It should be pointed out that, for the person of ordinary skill of the art, without departing from the present invention
On the premise of design, it is also possible to make some deformation and improvement, these belong to protection scope of the present invention.
Claims (10)
1. a nasal spray, it is characterised in that include each material of following weight portion:
Described natural organic acids is to contain and extractible acid in natural plant.
A kind of nasal spray the most according to claim 1, it is characterised in that described wetting agent is glucose, natural moisture preserving
The factor or hydrophilic amino acid.
A kind of nasal spray the most according to claim 1, it is characterised in that include each material of following weight portion:
A kind of nasal spray the most according to claim 3, it is characterised in that also including slow releasing agent, its weight portion is 11-35
Part, described slow releasing agent is acrylate polymer, poly butyric ester or chitosan.
A kind of nasal spray the most according to claim 1, it is characterised in that include each material of following weight portion:
A kind of nasal spray the most according to claim 5, it is characterised in that also including slow releasing agent, its weight portion is 5-15
Part, described slow releasing agent is acrylate polymer, poly butyric ester or chitosan.
A kind of nasal spray the most according to claim 1, it is characterised in that also including Sargassum polysaccharides, its weight portion is 23-
36 parts.
A kind of nasal spray the most according to claim 1, it is characterised in that described natural organic acids is preferably: salicylic acid,
Two kinds of a kind of or any mass ratio in the acid of malic acid, tartaric acid, citric acid, mandelic acid, Fructus Vitis viniferae, citric acid or lactic acid.
A kind of nasal spray the most according to claim 1, it is characterised in that also include stabilizer, the weight portion of stabilizer
For 1-5 part, described stabilizer is pectin.
10. the preparation method of an a kind of nasal spray as claimed in claim 1, it is characterised in that including: Herba Asparagi Setacei is mixed into
Water decocts into juice, then according to setting weight part ratio is by poly hexamethylene biguanide, normal saline, wetting agent, natural organic
Acid, Bulbus Allii juice, seed oil of Moringa oleigera, Oleum menthae and Herba Asparagi Setacei juice are mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610614841.0A CN106214926A (en) | 2016-07-29 | 2016-07-29 | A kind of nasal spray and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610614841.0A CN106214926A (en) | 2016-07-29 | 2016-07-29 | A kind of nasal spray and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106214926A true CN106214926A (en) | 2016-12-14 |
Family
ID=57536253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610614841.0A Pending CN106214926A (en) | 2016-07-29 | 2016-07-29 | A kind of nasal spray and preparation method thereof |
Country Status (1)
| Country | Link |
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Application publication date: 20161214 |