CN105770211A - Medical rhinitis antibacterial agent and preparation method thereof - Google Patents
Medical rhinitis antibacterial agent and preparation method thereof Download PDFInfo
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- CN105770211A CN105770211A CN201610145416.1A CN201610145416A CN105770211A CN 105770211 A CN105770211 A CN 105770211A CN 201610145416 A CN201610145416 A CN 201610145416A CN 105770211 A CN105770211 A CN 105770211A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/268—Asarum (wild ginger)
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- A61K2236/30—Extraction of the material
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- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a medical rhinitis antibacterial agent and a preparation method thereof. The antibacterial agent is prepared from small-molecule chitosan quaternary ammonium salt, physiological sea water and traditional Chinese medicine extract, wherein the traditional Chinese medicine extract is obtained by extracting centipede minima, Angelica dahurica, asarum, biond magnolia flowers, artemisia argyi, seeds of Vitis vinifera L., illicium verum and camellia seeds in water. The antibacterial agent has high bactericidal performance as well as good biocompatibility and broad-spectrum bacteria resistance at the same time, can inhibit and prevent tissue on the nasal mucosa or under the nasal mucosa from being infected by germs, repair injured tissue and relieve pains, has good adjunctive treatment and preventing effects on symptoms such as allergic rhinitis, acute or chronic rhinitis, as well as nasal obstruction, rhinalgia, nasal dryness and pruritus, rhinorrhea, nasosinusitis and the like of rihinitis, takes effect rapidly and is free of side effects; rhinitis cannot easily relapse, and the preparation method is simple.
Description
Technical field
The present invention relates to medical antibacterial agent field, be specifically related to a kind of medical rhinitis antibacterial and preparation method thereof.
Background technology
Rhinitis is one of common multiple nasal conditions, and the many meetings of patient show the symptoms such as nasal obstruction, watery nasal discharge, headache, hypomnesis, lassitude, drastically influence patient's daily life, working and learning.Also easily bring out the complication such as sinusitis, pharyngolaryngitis, otitis media such as delay treatment, patient needs treated as soon as possible.
The traditional therapy of rhinitis has:
1, Drug therapy: intranasal glucocorticoid, is rhinitis first-selection medication, has good antiinflammatory action, and finally produces congestion effect.But, take the rhinitis medicines such as antibiotic medicine, antibiotic, use nasal drop, though can alleviate and alleviate chronic rhinitis symptom to a certain extent, if but patient for a long time, excessively hormone abuse class and antibiotics rhinitis Drug therapy chronic rhinitis, can make patient body that fluid retention occurs, make pathogenic bacteria constantly make a variation simultaneously and there is drug resistance, thus bringing out the rhinitis that medicamentous rhinitis, atrophic rhinitis etc. are more serious.
2, operative treatment: the traditional operation treatment of rhinitis comprises the therapeutic method of surgery such as freezing, laser, microwave, radio frequency, but these physical therapy modalities are generally only applicable to proliferative lesion, and long-term effect is uncertain, Post operation to the local organization of nose also with destructiveness.
Therefore find that side effect is little, the antimicrobial agent of good anti-bacterial effect formulate suitable administrated method and be badly in need of for current.
Summary of the invention
It is an object of the invention to for the deficiencies in the prior art, it is provided that a kind of side effect is little, the medical rhinitis antibacterial of good anti-bacterial effect；
It is a further object of the present invention to provide a kind of medical rhinitis Antibacterial agent preparation method.
It is an object of the invention to by following technical scheme realization:
Medical rhinitis antibacterial of the present invention, it is to be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 0.1-15 part
Physiological seawater 0.1-10 part
Chinese medicine extraction liquid 1-97 part,
Wherein, the weight between the described raw material of Chinese medicine preparing Chinese medicine extraction liquid and each raw material of Chinese medicine is as follows:
Herba Centipedae 1-50 part, Radix Angelicae Dahuricae 1-5 part, Herba Asari 1-5 part, Flos Magnoliae 1-9 part, Folium Artemisiae Argyi 1-6 part, Semen Vitis viniferae 1-8 part, anistree 1-6 part, Camellia 1-8 part.
Preferably, it is to be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 5-10 part
Physiological seawater 3-8 part
Chinese medicine extraction liquid 30-70 part,
Wherein, the weight between the described raw material of Chinese medicine preparing Chinese medicine extraction liquid and each raw material of Chinese medicine is as follows:
Herba Centipedae 20-40 part, Radix Angelicae Dahuricae 3-5 part, Herba Asari 3-5 part, Flos Magnoliae 5-9 part, Folium Artemisiae Argyi 4-6 part, Semen Vitis viniferae 5-8 part, anistree 4-6 part, Camellia 5-8 part.
Described little molecular chitosan quaternary ammonium salt is for be composited for chitosan and quaternary ammonium salt..
The following is the crude drug source of raw material of Chinese medicine of the present invention:
Herba Centipedae, for feverfew Herba Centipedae Centipedaminima(L.) the dry herb of A.Br.etAschers..[nature and flavor] are pungent, temperature.[return through] returns lung, Liver Channel.[function cures mainly] clearing the nasal passage, cough-relieving, for headche due to wind-cold, cough with copious phlegm, have a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
The Radix Angelicae Dahuricae, for umbellate form section plant Radix Angelicae Dahuricae Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f. or Radix angelicae dahuricae Angelicadahurica(Fisch.exHoffm.) Benth.etHook.f.var.formosana(Boiss.) dry root of ShanetYuan.[nature and flavor] are pungent, temperature.[return through] returns stomach, large intestine, lung meridian.[function cures mainly] dissipates wind dehumidifying, sensible pain relieving, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Herba Asari, for aristolochiaceae plant Herba Asari AsarumheterotropoidesFr.Schmidtvar.mandshuricum(Maxim.) Kitag., Seoul Herba Asari AsarumsieboldiiMiq.var.seoulenseNakai or China Herba Asari AsarumsieboldiiMiq. dry herb.[nature and flavor] are pungent, temperature.[return through] GUIXIN, lung, kidney channel.[function cures mainly] expelling wind and cold, sensible pain relieving, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal sinusitis of having a stuffy nose, rheumatic arthralgia, phlegm retention is breathed with cough.
Flos Magnoliae, for the dry flower of Magnoliacea plant Flos Magnoliae MagnoliabiondiiPamp., Magnolia denudata MagnoliadenudataDesv. or Flos Magnoliae MagnoliasprengeriPamp..[nature and flavor] are pungent, temperature.[return through] attaches to the lung and stomach meridians.[function cures mainly] dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
Folium Artemisiae Argyi, the dry herb of the ArtemisiaargyiLevl.etVant. that ends for feverfew.[nature and flavor] are pungent, bitter, temperature；Slightly poisonous.[return through] returns liver,spleen,kidney warp.[function cures mainly] dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage；External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Semen Vitis viniferae, for the seed of Vitaceae Vitis plant Fructus Vitis viniferae VitisviniferaL. fruit.Containing polyphenols (GPS) in Semen Vitis viniferae, mainly there are catechin and procyanidin class；And containing abundant oils and fats, containing substantial amounts of unsaturated fatty acid in oil；Possibly together with a small amount of volatile ingredient in Semen Vitis viniferae, these materials belong to alcohol, phenol, terpene substances mostly, all have higher biological activity.Semen Vitis viniferae has free radical resisting, reduces the effects such as blood fat, antiallergic, protection blood vessel, radioprotective.Cell can be goed deep into and fundamentally suppress the release of sensitizing factor " histamine ", improve the cell toleration to anaphylactogen；Remove sensitization free radical, antiinflammatory, antiallergic；Stablize skin heart tissue, alleviate the various allergic symptoms such as urticaria, dry leather heat, allergic rhinitis；Effectively regulate immunity of organisms, thoroughly improve allergic constitution.
Anise, for the dry mature fruit of Magnoliacea plant Fructus Anisi Stellati IlliciumverumHook.f..[nature and flavor] are pungent, temperature.[return through] returns liver,kidney,spleen, stomach warp.[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.Suffer from abdominal pain for colic of cold type, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.
Camellia, for the seed of plant of theaceae oil tea.[nature and flavor] are bitter；Sweet；Flat；Poisonous [return through] spleen；Stomach；Large intestine channel [function cures mainly] circulation of qi promoting；Intestine moistening；Parasite killing.Main abdominal pain due to stagnation of QI；Dryness of the intestine constipation；Ascarid；Ancylostome；Scabies pruritus.
The preparation method of described Chinese medicine extraction liquid comprises the following steps:
Take whole raw material of Chinese medicine, add the distilled water immersion being equivalent to raw material of Chinese medicine gross weight 5-10 times after 1-2 hour, heating extraction 1-3 time, each amount of water is equivalent to 3-10 times of raw material of Chinese medicine gross weight, and each extraction time is 0.5-2 hour, united extraction liquid, filter, to obtain final product.
The preparation method that another aspect of the present invention there is provided medical rhinitis antibacterial of the present invention, its preparation method comprises the following steps:
(1) weigh whole raw material of Chinese medicine by weight, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) Chinese medicine extraction liquid and physiological seawater are joined in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
In medical rhinitis antiseptic prescription provided by the invention:
Chitosan be nature exists renewable, have no side effect, biocompatibility and the good native amino alkaline polysaccharide of degradability, himself and derivant thereof have the physiology of many uniquenesses, pharmacological function character and be widely used in the multiple industry fields such as medicine, food, environmental protection.Little molecular chitosan quaternary ammonium salt is the chemically modified modification of marine organisms chitosan and prepared chitosan higher derivative, the water soluble when any pH, range of application is wider, there is superior biocompatibility, biodegradability simultaneously, catabolite is nontoxic, without immunoreation, non-carcinogenesis, and there is the performances such as good film property, flocculability, antistatic behaviour.To very strong adsorb addicted to film and membranous structure, merge of pathogenic microorganism tool, change its permeability, cause its content to leak and cause its death；Tool broad-spectrum antiseptic, antiviral activity, it is not easily produced drug resistance by pathogenic microorganism.Little molecular chitosan quaternary ammonium salt is a class Novel Cationic Surfactants, and it has high temperature resistant, water-fastness, lasting effect, scope of restraining fungi is wide, can effectively suppress gram positive bacteria, gram negative bacteria, yeast and fungus etc..Its sterilization mechanism is: the ammonium cation group of the energy that has microbe killing properties is adsorbed in the surface of antibacterial forcefully, change the permeability of bacteria cell wall, endobacillary enzyme, coenzyme and metabolic intermediate is made to overflow, microorganism is caused to cease breathing function and lethal, thus reaching sterilization, antibacterial effect, namely there occurs " contact death ".Little molecular chitosan quaternary ammonium salt effectively increases antibacterial range and effect, bacterial cell membrane can be destroyed, bacteria cell wall can be destroyed again to make its content leak and cause its death, plus it, antibacterial is had the merit of " contact death ", quickly kill and make antibacterial cannot secrete resistance to drug metabolizing enzyme, reach overriding resistance summation action.
Physiological seawater, its osmotic pressure value and the blood plasma of normal person, tissue fluid are all much the same, it is possible to as fluid infusion (will not reduce and increase Na ion concentration in normal human) and other medical applications.Physiological seawater contains various trace elements due to it, so it also has sterilization, antivirus action (effect of Ag, Zn), anti-allergic effects (effect of Mn), antiinflammation (effect of Cu).
In Chinese medicine extraction liquid rich in multiple sensible, warming the meridian, dispel the wind, antiinflammatory, antibacterial, analgesic composition.
Herba Centipedae has clearing the nasal passage effect, can be used for having a stuffy nose obstructed, nasal sinusitis watery nasal discharge；The diseases such as the sensible pain relieving of the Radix Angelicae Dahuricae, Herba Asari, can be used for treatment nasal obstruction, nasal sinusitis；Flos Magnoliae has dispersing wind and cold, and clearing the nasal passage effect, for headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge；Folium Artemisiae Argyi, anistree dispelling cold by warming the meridian；Camellia circulation of qi promoting；Semen Vitis viniferae antiinflammatory, antiallergic, effectively regulate immunity of organisms, thoroughly improves allergic constitution.
Medical rhinitis antibacterial provided by the invention has the advantage that antibacterial dressing adopts little molecular chitosan quaternary ammonium salt, physiological seawater, Chinese medicine extraction liquid combines, bactericidal property is higher, there is the biocidal property of good biocompatibility and wide spectrum simultaneously, can suppress and prevent nasal mucosa or sub-mucosal tissues courses of infection, damaged tissues can be repaired, reduce pain, to allergic rhinitis, acute and chronic rhinitis and nasal obstruction thereof, rhinalgia, dryness in the nasal cavity is itched, rhinorrhea, the symptoms such as sinusitis have good auxiliary treatment and preventive effect, rapid-action, not easily recur, have no side effect, preparation method is simple.
Detailed description of the invention
Further illustrate the present invention by the examples below.It should be understood that embodiments of the invention are an illustration for the present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the scope of protection of present invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 0.1g
Physiological seawater 0.1g
Chinese medicine extraction liquid 97g,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 50g, Radix Angelicae Dahuricae 5g, Herba Asari 5g, Flos Magnoliae 9g, Folium Artemisiae Argyi 6g, Semen Vitis viniferae 8g, anistree 6g, Camellia 8g.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, after adding the distilled water immersion 1h being equivalent to medical material gross weight 10 times, heating extraction, first time extracts 2h, second time amount of water is equivalent to 5 times of medical material gross weight, extracting 30min, third time amount of water is equivalent to 3 times of medical material gross weight, extracts 30min, united extraction liquid, filter, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 2
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 15g
Physiological seawater 10g
Chinese medicine extraction liquid 1g,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 1g, Radix Angelicae Dahuricae 1g, Herba Asari 1g, Flos Magnoliae 1g, Folium Artemisiae Argyi 1g, Semen Vitis viniferae 1g, anistree 1g, Camellia 1g.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, after adding the distilled water immersion 2h being equivalent to medical material gross weight 5 times, heating extraction 1h, second time amount of water is equivalent to 8 times of medical material gross weight, extracts 60min, third time amount of water is equivalent to 6 times of medical material gross weight, extract 60min, united extraction liquid, filter, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 3
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 50g
Physiological seawater 80g
Chinese medicine extraction liquid 700g,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 200g, Radix Angelicae Dahuricae 30g, Herba Asari 30g, Flos Magnoliae 50g, Folium Artemisiae Argyi 40g, Semen Vitis viniferae 50g, anistree 40g, Camellia 50g.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, after adding the distilled water immersion 1.5h being equivalent to medical material gross weight 6 times, heating extraction 1.5h, second time amount of water is equivalent to 6 times of medical material gross weight, extracts 45min, third time amount of water is equivalent to 4 times of medical material gross weight, extract 45min, united extraction liquid, filter, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 4
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 100g
Physiological seawater 30g
Chinese medicine extraction liquid 300g,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 300g, Radix Angelicae Dahuricae 40g, Herba Asari 40g, Flos Magnoliae 60g, Folium Artemisiae Argyi 50g, Semen Vitis viniferae 60g, anistree 50g, Camellia 60g.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, after adding the distilled water immersion 1.5h being equivalent to medical material gross weight 8 times, heating extraction 2h, second time amount of water is equivalent to 7 times of medical material gross weight, extracts 60min, united extraction liquid, filter, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 5
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 80g
Physiological seawater 50g
Chinese medicine extraction liquid 500g,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 350g, Radix Angelicae Dahuricae 35g, Herba Asari 45g, Flos Magnoliae 80g, Folium Artemisiae Argyi 45g, Semen Vitis viniferae 70g, anistree 50g, Camellia 70g.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) weighing whole raw material of Chinese medicine by weight, after adding the distilled water immersion 2h being equivalent to medical material gross weight 7 times, heating extraction 1.5h, extracting solution filters, and prepares Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 6
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 3kg
Physiological seawater 1kg
Chinese medicine extraction liquid 90kg,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 45kg, Radix Angelicae Dahuricae 4.5kg, Herba Asari 4.5kg, Flos Magnoliae 7.5kg, Folium Artemisiae Argyi 5.5kg, Semen Vitis viniferae 7.5kg, anistree 4.3kg, Camellia 4kg.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) weighing whole raw material of Chinese medicine by weight, after adding the distilled water immersion 2h being equivalent to medical material gross weight 9 times, heating extraction 2h, second time amount of water is equivalent to 6 times of medical material gross weight, extracts 1h, united extraction liquid, filters, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 7
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 12kg
Physiological seawater 9kg
Chinese medicine extraction liquid 20kg,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 25kg, Radix Angelicae Dahuricae 3.5kg, Herba Asari 3.5kg, Flos Magnoliae 5.5kg, Folium Artemisiae Argyi 4.3kg, Semen Vitis viniferae 6.2kg, anistree 5.8kg, Camellia 6.5kg.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, after adding the distilled water immersion 2h being equivalent to medical material gross weight 8 times, heating extraction 1h, second time amount of water is equivalent to 5 times of medical material gross weight, extracts 0.5h, third time amount of water is equivalent to 5 times of medical material gross weight, extract 0.5h, united extraction liquid, filter, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Embodiment 7
A kind of medical rhinitis antibacterial, is be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 7kg
Physiological seawater 4kg
Chinese medicine extraction liquid 40kg,
Described Chinese medicine extraction liquid is to be extracted by the raw material of Chinese medicine of following weight portion to be prepared from:
Herba Centipedae 10kg, Radix Angelicae Dahuricae 1.5kg, Herba Asari 2.5kg, Flos Magnoliae 3.5kg, Folium Artemisiae Argyi 2.5kg, Semen Vitis viniferae 4.5kg, anistree 3.8kg, Camellia 2.5kg.
The preparation method of a kind of medical rhinitis antibacterial comprises the following steps:
(1) weighing whole raw material of Chinese medicine by weight, after adding the distilled water immersion 1.5h being equivalent to medical material gross weight 6 times, heating extraction 2h, second time amount of water is equivalent to 6 times of medical material gross weight, extracts 1h, united extraction liquid, filters, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) weigh Chinese medicine extraction liquid and physiological seawater by weight, join in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
Clinical trial
1 physical data
Test patient has 150 people altogether, and patient's course of disease maximum duration is 6 years.All cases is diagnosed as rhinitis all in accordance with the diagnosis basis in rhinitis diagnoses and treatment, and cardinal symptom is nasal obstruction, rhinocnesmus, rhinorrhea, sneeze, headache, hyposmia, and severe one increases with nasal secretions.
2 Therapeutic Method
Experimenter's morning, noon and afternoon every day use medical rhinitis antibacterial described in the embodiment of the present invention 3, each 2～3, within 7 days, are a course for the treatment of, observe curative effect after 21 days.
3 efficacy evaluations
Effective: transference cure, BITONG gas, nasal mucosa recover normal, and nasal cavity checks without secretions；
Effective: symptom is obviously improved, nasal discharge reduce, time have nasal obstruction；
Invalid: symptom and check front with treatment unchanged.
Total effective rate=(effective+effectively)/total number of cases × 100%.
5 results
Through the treatment of three courses for the treatment of, clinical efficacy is in Table 1.
Table 1 present invention treats the clinical efficacy of rhinitis
| n | Effective | Effectively | Invalid | Total effective rate (%) | |
| Curative effect | 150 | 145 | 3 | 2 | 98.67 |
As shown in Table 1, after the treatment of three courses for the treatment of, the total effective rate of rhinitis is 98.67% by the present invention.Result shows: rhinitis is had good therapeutical effect by medical rhinitis antibacterial of the present invention, and can alleviate the clinical symptoms of various rhinitis.
Model case
Ms Zhang, female, 28 years old, suffers from chronic rhinitis 5 years, persistence nasal obstruction, rhinorrhea, adopted western medicine, but had little effect, often recurred, 3 courses for the treatment of of medical rhinitis antibacterial described in the rear use embodiment of the present invention 1, Rhinitis Symptoms disappears, and ventilates, no headache, in two years without recurrence.
Mr. Wang, man, 48 years old, suffer from allergic rhinitis 4 years, early morning frequent sneeze, stream clear water sample nasal mucus, frequent rhinocnesmus, nasal membrane is pale, hyposmia, after using described in the embodiment of the present invention 43 courses for the treatment of of medical rhinitis antibacterial, transference cure, nasal membrane repairs, without recurrence.
Mrs Gao, female, 55 years old, suffers from chronic sinusitis 3 years, nasal obstruction is serious, headache, concha nasalis enlargement, through using 2 courses for the treatment of of medical rhinitis antibacterial, transference cure described in the embodiment of the present invention 2, ventilate, concha nasalis enlargement disappears, and headache alleviates, and after continuing one course for the treatment of of medication, symptom disappears entirely.
Mr. Zhao, man, 35 years old, suffer from chronic rhinitis 6 years, instantaneous rhinocnesmus, after using described in the embodiment of the present invention 53 courses for the treatment of of medical rhinitis antibacterial, transference cure, without recurrence.
Miss Wu, female, 45 years old, suffer from acute rhinitis 1 year, frequent sneeze, dryness in the nasal cavity is itched, and after using described in the embodiment of the present invention 12 courses for the treatment of of medical rhinitis antibacterial, the state of an illness is clearly better, and dryness in the nasal cavity is itched disappearance.
Mrs Fang, female 30 years old, suffer from allergic rhinitis 2 years, frequent sneeze, flow clear water sample nasal mucus, after using described in the embodiment of the present invention 32 courses for the treatment of of medical rhinitis antibacterial, transference cure, without recurrence.
Mr. Li, man, 53 years old, suffer from chronic rhinitis 3 years, nasal obstruction, headache, rhinorrhea, after using described in the embodiment of the present invention 62 courses for the treatment of of medical rhinitis antibacterial, headache alleviates, and ventilate, and after one course for the treatment of of continuation medication, symptom disappears entirely, does not recur in 1 year.
Wei little Ming, man, 15 years old, suffer from allergic rhinitis 30 days, nasal obstruction, dryness in the nasal cavity are itched, have a headaches, frequent sneeze, and after 1 course for the treatment of of medical rhinitis antibacterial described in the use embodiment of the present invention 8, symptom disappears entirely, does not recur in 1 year.
Zhang Xiaohong, female, 12 years old, suffer from acute rhinitis 1 year, frequent sneeze, instantaneous rhinocnesmus, after using described in the embodiment of the present invention 72 courses for the treatment of of medical rhinitis antibacterial, symptom disappears entirely.Do not recur in 1 year.
Although, above use generality explanation, detailed description of the invention and test, the present invention is described in detail, but on basis of the present invention, it is possible to it is made some modifications or improvements, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (4)
1. a medical rhinitis antibacterial, it is characterised in that it is to be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 0.1-15 part
Physiological seawater 0.1-10 part
Chinese medicine extraction liquid 1-97 part；
Wherein, the weight between the described raw material of Chinese medicine preparing Chinese medicine extraction liquid and each raw material of Chinese medicine is as follows:
Herba Centipedae 1-50 part, Radix Angelicae Dahuricae 1-5 part, Herba Asari 1-5 part, Flos Magnoliae 1-9 part, Folium Artemisiae Argyi 1-6 part, Semen Vitis viniferae 1-8 part, anistree 1-6 part, Camellia 1-8 part.
2. medical rhinitis antibacterial as claimed in claim 1, it is characterised in that it is to be prepared from by the raw material of following weight portion:
Little molecular chitosan quaternary ammonium salt 5-10 part
Physiological seawater 3-8 part
Chinese medicine extraction liquid 30-70 part,
Wherein, the weight between the described raw material of Chinese medicine preparing Chinese medicine extraction liquid and each raw material of Chinese medicine is as follows:
Herba Centipedae 20-40 part, Radix Angelicae Dahuricae 3-5 part, Herba Asari 3-5 part, Flos Magnoliae 5-9 part, Folium Artemisiae Argyi 4-6 part, Semen Vitis viniferae 5-8 part, anistree 4-6 part, Camellia 5-8 part.
3. medical rhinitis antibacterial as claimed in claim 1 or 2, it is characterised in that the preparation method of described Chinese medicine extraction liquid comprises the following steps:
Take whole raw material of Chinese medicine, add the distilled water immersion being equivalent to raw material of Chinese medicine gross weight 5-10 times after 1-2 hour, heating extraction 1-3 time, each amount of water is equivalent to 3-10 times of raw material of Chinese medicine gross weight, and each extraction time is 0.5-2 hour, united extraction liquid, filter, to obtain final product.
4. medical rhinitis antibacterial as claimed in claim 1 or 2, it is characterised in that its preparation method comprises the following steps:
(1) whole raw material of Chinese medicine is weighed by weight, add the distilled water immersion being equivalent to medical material gross weight 5-10 times after 1-2 hour, heating extraction 1-3 time, each amount of water is equivalent to 3-10 times of medical material gross weight, each extraction time is 0.5-2 hour, united extraction liquid, filters, prepare Chinese medicine extraction liquid, standby；
(2) little molecular chitosan quaternary ammonium salt is added in purified water, so as to fully dissolve, obtain little molecular chitosan quaternary ammonium salt solution, standby；
(3) Chinese medicine extraction liquid and physiological seawater are joined in little molecular chitosan quaternary ammonium salt solution, stir, obtain described medical rhinitis antibacterial.
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| CN108713641A (en) * | 2018-05-08 | 2018-10-30 | 广东海洋大学 | A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive and its preparation method and application |
| CN112843091A (en) * | 2021-01-11 | 2021-05-28 | 云南中翼鼎东生物医疗科技有限公司 | Rhinitis antibacterial spray containing lignite extract and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108713641B (en) * | 2018-05-08 | 2021-09-07 | 广东海洋大学 | Chitosan quaternary ammonium salt and Chinese herbal medicine compound feed additive as well as preparation method and application thereof |
| CN112843091A (en) * | 2021-01-11 | 2021-05-28 | 云南中翼鼎东生物医疗科技有限公司 | Rhinitis antibacterial spray containing lignite extract and preparation method and application thereof |
| CN112843091B (en) * | 2021-01-11 | 2022-10-18 | 云南中翼鼎东生物医疗科技有限公司 | Rhinitis antibacterial spray containing lignite extract and preparation method and application thereof |
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