CN108713641A - A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive and its preparation method and application - Google Patents
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A23K50/00—Feeding-stuffs specially adapted for particular animals
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- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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Abstract
The invention discloses a kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additives and its preparation method and application.The composite feed additive includes Chinese medicinal component and chitosan quaternary ammonium salt, and the Chinese medicinal component is made of the raw material of following mass fraction：10~30 parts of dried orange peel, 40~60 parts of Radix Astragali, 30~50 parts of Radix Isatidis, 20~40 parts of cordate houttuynia, 20~40 parts of granatum, 10~30 parts of radish seed, 15~35 parts of radix bupleuri, 20~40 parts of the coptis, 8~20 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1：1~3.It cooperates between composite feed additive each component of the present invention, plays synergistic function, securely and reliably；There is prevention and/or therapeutic effect well for pig inflammatory bowel disease, can effectively reduce the generation of diarrhea of pigs rate；The growth efficiency of pig also can be improved.In addition, it is raw materials used it is cheap be easy to get, and noresidue, passivity pharmacological property and have no toxic side effect.
Description
Technical field
The invention belongs to field of feed additive technology, multiple more particularly, to a kind of chitosan quaternary ammonium salt and Chinese herbal medicine
Close feed addictive and its preparation method and application.
Background technology
Pig inflammatory bowel disease is common enteron aisle class disease in pig production, generally with communicable disease caused by bacterium and virus
Based on, including pig epidemic diarrhea, dysentery, transmissible gastroenteritis etc., the form of expression are mainly diarrhea, while also with body temperature liter
The symptoms such as high, loss of appetite, dehydration.Cause pig slow-growing, the price of deed declines, and production performance declines, or even causes pig
Death seriously affects the economic benefit of aquaculture.
The method of traditional treatment inflammatory bowel disease is prevented and treated with some antibiotic mostly, as gentamicin,
Amoxicillin, orfloxacin etc., but the excessive use of these drugs may result in some bad consequences, for example generate drug resistance
Property, cause toxicity, medicament residue and archenteric flora imbalance, cause pig intestinal immunity decline and eat these
It exerts an adverse impact to human body after animal.
Chinese herbal medicine comes from the Nature, and resource is extensive and cheap, has nutrition and medicinal double action concurrently, has a variety of work(
Effect, and toxic side effect is small, using Chinese medicine as raw material, studies the effective drug for preventing and/or treating inflammatory bowel disease or feeding
Feed additives have great application value in aquaculture.
Invention content
It is compound the purpose of the invention is to overcome the deficiencies of the prior art and provide a kind of chitosan quaternary ammonium salt and Chinese herbal medicine
Feed addictive.Composite feed additive of the present invention is compounded to obtain using chitosan quaternary ammonium salt and 9 taste Chinese medicines as raw material,
It cooperates between each component, plays synergistic function, securely and reliably；For pig inflammatory bowel disease have well prevent and/
Or therapeutic effect, but also the growth efficiency of pig can be improved.
Another object of the present invention is to provide the preparations of the chitosan quaternary ammonium salt and Chinese herbal composite feed additive
Method.
It is still another object of the present invention to provide the chitosan quaternary ammonium salts and Chinese herbal composite feed additive to prevent
And/or the application in treatment pig inflammatory bowel disease.
The above-mentioned purpose of the present invention is achieved by the following technical programs：
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, the composite feed additive include Chinese medicinal component and shell
Glycan quaternary ammonium salt, the Chinese medicinal component include the raw material of following mass fraction：10~30 parts of dried orange peel, 40~60 parts of Radix Astragali, plate are blue
30~50 parts of root, 20~40 parts of cordate houttuynia, 20~40 parts of granatum, 10~30 parts of radish seed, 15~35 parts of radix bupleuri, the coptis 20~
40 parts, 8~20 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1:1~3.
Dried orange peel, radish seed, cordate houttuynia, radix bupleuri have the effects that spleen benefiting and stimulating the appetite, astringing to arrest diarrhea, cure mainly dyspeptic abdominal distention, bacillary dysentery abdomen
It rushes down.
The coptis, Radix Isatidis, granatum have the effects that clearing heat and detoxicating, cool blood detumescence, treating acute and chronic hepatitis and antiviral sense
Dye.
Radix Astragali, Radix Angelicae Sinensis have invigorating qi for strengthening superficies, expelling pus and promoting granulation, for treatment deficiency of vital energy weak, long let out rectal prolapse etc..
Chitosan is to belong to amino-containing homogeneous state straight-chain polysaccharide derivative, a kind of application from chitin deacylation base
The extensive green feed additive of foreground.Antibacterial activity with wide spectrum has gram-positive bacteria and Candida albicans bright
Aobvious inhibiting effect has the effects that immune, protection.Chitosan quaternary ammonium salt is the derivative of chitosan, is by the ammonia of chitosan
Base is as obtained from introducing group and be converted into quaternary ammonium salt or a low molecule quaternary ammonium salt is connected on amino.Chitosan quaternary ammonium
Salt is polycationic compounds, have good water solubility, flocculability, biological compatibility, moisture absorbability and moisture retentivity and antibiotic property and
The features such as capable of promoting drug absorption, application range is quite extensive.
Chitosan quaternary ammonium salt and Chinese medicinal component are used in compounding by the present invention, and chitosan quaternary ammonium salt can not only promote Chinese medicine
The absorption of component, moreover it is possible to which the growth for inhibiting bacterium enhances the immune function of body.
Preferably, the Chinese medicinal component is made of the raw material of following mass fraction：15~25 parts of dried orange peel, Radix Astragali 45~55
Part, 35~45 parts of Radix Isatidis, 25~35 parts of cordate houttuynia, 25~35 parts of granatum, 15~25 parts of radish seed, 20~30 parts of radix bupleuri,
25~35 parts of the coptis, 10~18 parts of Radix Angelicae Sinensis.
Preferably, the Chinese medicinal component is made of the raw material of following mass fraction：20 parts of dried orange peel, 50 parts of Radix Astragali, Radix Isatidis
40 parts, 30 parts of cordate houttuynia, 30 parts of granatum, 20 parts of radish seed, 25 parts of radix bupleuri, 30 parts of the coptis, 15 parts of Radix Angelicae Sinensis.
Preferably, the chitosan quaternary ammonium salt respectively by molecular weight be 800~1200,2000~2500,40000~
60000 chitosan quaternary ammonium salt is with mass ratio for 1~3:1~3:1~3 composition.
Preferably, the chitosan quaternary ammonium salt respectively by molecular weight be 900~1100,2100~2300,45000~
55000 chitosan quaternary ammonium salt is with mass ratio for 1~2:1~2:1~2 composition.
It is highly preferred that the chitosan quaternary ammonium salt that the chitosan quaternary ammonium salt is respectively 1000,2200 and 50000 by molecular weight
It is 1 in mass ratio:1:1 composition.
Preferably, the chitosan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1:2.
The present invention also protects the preparation method of the composite feed additive simultaneously.The preparation method includes following step
Suddenly：Each taste Chinese medicine in formula is chosen, removes the impurity of drug and non-medicinal effects respectively, ensures that medicinal effects water content is low
In 10%, and according to formula ratio mixing, crushing, the sieve of 100~200 mesh excessively；Then with chitosan quaternary ammonium salt mixing, be drying to obtain institute
State composite feed additive.
The application of the composite feed additive is also within protection scope of the present invention.The composite feed additive exists
Additive amount in pannage is the 1~2% of gross mass.
Preferably, additive amount of the composite feed additive in pannage is the 1.5% of gross mass.
Compared with prior art, the present invention has the advantages that：
Composite feed additive of the present invention is to be compounded to obtain as raw material using chitosan quaternary ammonium salt and 9 taste Chinese medicines, each group
/ mutual cooperation, plays synergistic function, securely and reliably；Have for pig inflammatory bowel disease and prevents and/or control well
Therapeutic effect, compared with the control group, diarrhea rate are significantly improved；But also the growth efficiency of pig can be improved.In addition, described
Low in raw material price used by composite feed additive is easy to get, and has nutrition and medicinal double action concurrently, and with noresidue,
The advantages of resisting pharmacological property, having no toxic side effect.
Specific implementation mode
The present invention is made with reference to specific embodiment and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method used in following embodiments is normal unless otherwise specified
Rule method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment 1
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, Chinese medicinal component are made of the raw material of following mass fraction：
20 parts of dried orange peel, 50 parts of Radix Astragali, 40 parts of Radix Isatidis, 30 parts of cordate houttuynia, 30 parts of granatum, 20 parts of radish seed, 25 parts of radix bupleuri, the coptis 30
Part, 15 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt that molecular weight is respectively 1000,2200,50000 is respectively 100g；Chitosan quaternary ammonium salt
Mass ratio with Chinese medicinal component is 1：2.
The preparation method of composite feed additive is：
（1）Dried orange peel, Radix Astragali, Radix Isatidis, cordate houttuynia, granatum, radish seed, radix bupleuri, the coptis, Radix Angelicae Sinensis are taken, removes drug respectively
Impurity and non-medicinal effects, the water content in material medicine should be less than 10%, and claim the material medicine chosen by above-mentioned formula
It is good spare；
（2）Admixed together be put into pulverizer of ready raw material is crushed, and crosses 100~120 mesh and sieves to obtain coarse powder, it is standby
With；
（3）It is respectively 1000,2200,50000 chitosan quaternary ammonium salt mixing machine by coarse powder obtained in the previous step and molecular weight
It mixes, then the drug mixed is dried, is packaged to be composite feed additive, and be sealed.
Embodiment 2
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, Chinese medicinal component are made of the raw material of following mass fraction：
18 parts of dried orange peel, 48 parts of Radix Astragali, 38 parts of Radix Isatidis, 28 parts of cordate houttuynia, 28 parts of granatum, 18 parts of radish seed, 23 parts of radix bupleuri, the coptis 28
Part, 13 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt that molecular weight is respectively 1000,2200,50000 is respectively 100g, 200g, 300g；Shell
Glycan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1：3.
The preparation method of composite feed additive is same as Example 1.
Embodiment 3
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, Chinese medicinal component are made of the raw material of following mass fraction：
22 parts of dried orange peel, 48 parts of Radix Astragali, 42 parts of Radix Isatidis, 33 parts of cordate houttuynia, 33 parts of granatum, 22 parts of radish seed, 28 parts of radix bupleuri, the coptis 33
Part, 16 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt that molecular weight is respectively 1000,2200,50000 is respectively 200g, 300g, 100g；Shell
Glycan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1：1.
The preparation method of composite feed additive is same as Example 1.
Embodiment 4
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, Chinese medicinal component are made of the raw material of following mass fraction：
20 parts of dried orange peel, 48 parts of Radix Astragali, 38 parts of Radix Isatidis, 28 parts of cordate houttuynia, 28 parts of granatum, 17 parts of radish seed, 25 parts of radix bupleuri, the coptis 28
Part, 15 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt that molecular weight is respectively 1000,2200,50000 is respectively 300g, 100g, 200g；Shell
Glycan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1：2.
The preparation method of composite feed additive is same as Example 1.
Embodiment 5
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 1, the difference is that shell is poly-
The molecular weight 1000 of sugared quaternary ammonium salt.
Embodiment 6
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 1, the difference is that shell is poly-
The molecular weight 2200 of sugared quaternary ammonium salt.
Embodiment 7
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 1, the difference is that shell is poly-
The molecular weight 50000 of sugared quaternary ammonium salt.
Embodiment 8
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 2, the difference is that shell is poly-
The molecular weight 50000 of sugared quaternary ammonium salt.
Embodiment 9
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 1, the difference is that shell is poly-
It is 1 in mass ratio that sugared quaternary ammonium salt, which is 1000 and 50000 by molecular weight,:1 composition.
Embodiment 10
A kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, traditional Chinese medicinal components are with embodiment 1, the difference is that shell is poly-
It is 1 in mass ratio that sugared quaternary ammonium salt, which is 2200 and 50000 by molecular weight,:2 compositions.
11 concrete application example of embodiment
1, the application in weanling pig
（1）Test method：Weanling pig 220 is chosen, is divided into 22 groups, one group is blank control group, and one group is control group, remaining
Group is test group.Blank control group and control group fed normal diet are added to above-described embodiment in the feed of test group feeding
In composite feed additive.Feeding manner is free water, is freely eaten, and gives control group and test group to be inoculated with large intestine afterwards for 24 hours
Bacillus, blank group are not inoculated with, and record 120h disease conditions.
（2）Test result：
Experiment grouping, the feed type of feeding and test result are as shown in table 1.
The traditional Chinese medicinal components in embodiment 1 are wherein only added in comparative example 1, do not add chitosan quaternary ammonium salt；Comparative example 2 is only
The traditional Chinese medicinal components in embodiment 2 are added, chitosan quaternary ammonium salt is not added；Comparative example 3 is the Chinese medicine group only added in embodiment 3
Point, do not add chitosan quaternary ammonium salt；Comparative example 4 is the traditional Chinese medicinal components only added in embodiment 4, does not add chitosan quaternary ammonium salt；
Comparative example 5 is the chitosan quaternary ammonium salt only added in embodiment 1, does not add traditional Chinese medicinal components；Comparative example 6 is only to add embodiment 2
In chitosan quaternary ammonium salt, do not add traditional Chinese medicinal components.
Feed addictive mass ratio is the ratio that feed addictive accounts for gross mass.
Table 1
| Group | Feed | Feed addictive | Feed addictive mass ratio (%) | Diarrhea rate (%) |
| Blank control group | Normal diet | - | - | It is unchanged |
| Normal control | Normal diet | - | 0 | 100 |
| Comparative example 1 | Normal diet | The traditional Chinese medicinal components of embodiment 1 | 1.5 | 70 |
| Comparative example 2 | Normal diet | The traditional Chinese medicinal components of embodiment 2 | 1.5 | 70 |
| Comparative example 3 | Normal diet | The traditional Chinese medicinal components of embodiment 3 | 1.5 | 70 |
| Comparative example 4 | Normal diet | The traditional Chinese medicinal components of embodiment 4 | 1.5 | 70 |
| Comparative example 5 | Normal diet | The chitosan quaternary ammonium salt of embodiment 1 | 1.5 | 50 |
| Comparative example 6 | Normal diet | The chitosan quaternary ammonium salt of embodiment 2 | 1.5 | 60 |
| Comparative example 7 | Normal diet | The chitosan quaternary ammonium salt of embodiment 3 | 1.5 | 60 |
| Comparative example 8 | Normal diet | The chitosan quaternary ammonium salt of embodiment 4 | 1.5 | 60 |
| Experiment 1 | Normal diet | 1 composite feed additive of embodiment | 1 | 30 |
| Experiment 2 | Normal diet | 1 composite feed additive of embodiment | 2 | 30 |
| Experiment 3 | Normal diet | 1 composite feed additive of embodiment | 1.5 | 10 |
| Experiment 4 | Normal diet | 2 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 5 | Normal diet | 3 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 6 | Normal diet | 4 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 7 | Normal diet | 5 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 8 | Normal diet | 6 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 9 | Normal diet | 7 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 10 | Normal diet | 8 composite feed additive of embodiment | 1.5 | 30 |
| Experiment 11 | Normal diet | 9 composite feed additive of embodiment | 1.5 | 30 |
| Experiment 12 | Normal diet | 10 composite feed additive of embodiment | 1.5 | 30 |
It is found that using in prevention of diarrhea in piglets in from the above, although individually traditional Chinese medicinal components or chitosan quaternary ammonium
Salt has some improvement to the diarrhea rate tool of piglet, but the diarrhea rate of piglet is still higher；And it is of the present invention compound
Feed addictive then has obvious action to the diarrhea rate of piglet, be added to the grice diarrhoea rate of composite feed additive with it is right
It is compared according to group, diarrhea rate reduces at least 60%.And for the chitosan quaternary ammonium salt of the addition in composite feed additive, when adding
When adding the chitosan quaternary ammonium salt of various molecular weights, it is better than the chitosan season of addition unimodal molecular weight to the improvement result of young diarrhea rate
Ammonium salt；And when adding the chitosan quaternary ammonium salt of 3 kinds of molecular weight, it is the most apparent to the improvement result of young diarrhea rate, than only adding
Chinese medicinal component and the grice diarrhoea rate for being only added to chitosan quaternary ammonium salt reduce at least 30% and 10%, and feed addictive
Additive amount effect when accounting for feed total amount 1.5% is better than other concentration.
Result above is explainable, has synergistic work in composite feed additive of the present invention between each component
With being got well than individually adding the effect of Chinese medicine or chitosan quaternary ammonium salt, the additive amount of feed addictive is accounting for feed total amount
Effect is better than other concentration when 1.5%, and the chitosan season mixed with 3 molecular weight using the Chinese medicine content of embodiment 1
The compound effect as feed addictive of ammonium salt is best, most apparent to the preventive and therapeutic effect of the diarrhea of piglet.
2, the application in Adult Pig
（1）In addition to test object is Adult Pig, other test methods are the same as weanling pig test example.
（2）Test result：
| Group | Feed | Feed addictive | Feed addictive mass ratio (%) | Diarrhea rate (%) |
| Blank control group | Normal diet | - | - | It is unchanged |
| Normal control | Normal diet | - | 0 | 90 |
| Comparative example 1 | Normal diet | The traditional Chinese medicinal components of embodiment 1 | 1.5 | 60 |
| Comparative example 2 | Normal diet | The traditional Chinese medicinal components of embodiment 2 | 1.5 | 60 |
| Comparative example 3 | Normal diet | The traditional Chinese medicinal components of embodiment 3 | 1.5 | 60 |
| Comparative example 4 | Normal diet | The traditional Chinese medicinal components of embodiment 4 | 1.5 | 60 |
| Comparative example 5 | Normal diet | The chitosan quaternary ammonium salt of embodiment 1 | 1.5 | 50 |
| Comparative example 6 | Normal diet | The chitosan quaternary ammonium salt of embodiment 2 | 1.5 | 60 |
| Comparative example 7 | Normal diet | The chitosan quaternary ammonium salt of embodiment 3 | 1.5 | 60 |
| Comparative example 8 | Normal diet | The chitosan quaternary ammonium salt of embodiment 4 | 1.5 | 60 |
| Experiment 1 | Normal diet | 1 composite feed additive of embodiment | 1 | 30 |
| Experiment 2 | Normal diet | 1 composite feed additive of embodiment | 2 | 30 |
| Experiment 3 | Normal diet | 1 composite feed additive of embodiment | 1.5 | 10 |
| Experiment 4 | Normal diet | 2 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 5 | Normal diet | 3 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 6 | Normal diet | 4 composite feed additive of embodiment | 1.5 | 20 |
| Experiment 7 | Normal diet | 5 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 8 | Normal diet | 6 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 9 | Normal diet | 7 composite feed additive of embodiment | 1.5 | 40 |
| Experiment 10 | Normal diet | 8 composite feed additive of embodiment | 1.5 | 30 |
| Experiment 11 | Normal diet | 9 composite feed additive of embodiment | 1.5 | 30 |
| Experiment 12 | Normal diet | 9 composite feed additive of embodiment | 1.5 | 30 |
In from the above it is found that preventing using for adult diarrhea of pigs, although individually traditional Chinese medicinal components or chitosan season
Ammonium salt has some improvement to the diarrhea rate tool of piglet, but the diarrhea rate of piglet is still higher；And it is of the present invention multiple
Closing feed addictive has remarkable effect, is added to the Adult Pig diarrhea rate of composite feed additive compared with the control group, diarrhea
Rate reduces at least 50%.And for the chitosan quaternary ammonium salt of the addition in composite feed additive, when addition various molecular weights
When chitosan quaternary ammonium salt, it is better than the chitosan quaternary ammonium salt of addition unimodal molecular weight to the improvement result of young diarrhea rate；And when addition 3
It is the most apparent to the improvement result of young diarrhea rate when the chitosan quaternary ammonium salt of kind of molecular weight, than being only added to Chinese medicinal component and only
Being added to the grice diarrhoea rate of chitosan quaternary ammonium salt reduces at least 20% and 10%, and the additive amount of feed addictive is accounting for feed
Effect is better than other concentration when total amount 1.5%.
Result above is explainable, has synergistic work in composite feed additive of the present invention between each component
With being got well than individually adding the effect of traditional Chinese medicinal components or chitosan quaternary ammonium salt；And it is total in traditional Chinese medicinal components and chitosan quaternary ammonium salt
With in use, using different molecular weight mixing chitosan quaternary ammonium salt it is better；Implement in the above-mentioned test example enumerated
The effect of composite feed additive is best in example 1, to piglet and at pig diarrhoea prevention effect it is optimal.
Claims (10)
1. a kind of chitosan quaternary ammonium salt and Chinese herbal composite feed additive, which is characterized in that the composite feed additive packet
Include Chinese medicinal component and chitosan quaternary ammonium salt；The Chinese medicinal component includes the raw material of following mass fraction：10~30 parts of dried orange peel, Radix Astragali
40~60 parts, 30~50 parts of Radix Isatidis, 20~40 parts of cordate houttuynia, 20~40 parts of granatum, 10~30 parts of radish seed, radix bupleuri 15~
35 parts, 20~40 parts of the coptis, 8~20 parts of Radix Angelicae Sinensis；The chitosan quaternary ammonium salt and the mass ratio of Chinese medicinal component are 1:1~3.
2. composite feed additive according to claim 1, which is characterized in that the Chinese medicinal component is by following mass fraction
Raw material forms：15~25 parts of dried orange peel, 45~55 parts of Radix Astragali, 35~45 parts of Radix Isatidis, 25~35 parts of cordate houttuynia, granatum 25~35
Part, 15~25 parts of radish seed, 20~30 parts of radix bupleuri, 25~35 parts of the coptis, 10~18 parts of Radix Angelicae Sinensis.
3. composite feed additive according to claim 2, which is characterized in that the Chinese medicinal component is by following mass fraction
Raw material forms：20 parts of dried orange peel, 50 parts of Radix Astragali, 40 parts of Radix Isatidis, 30 parts of cordate houttuynia, 30 parts of granatum, 20 parts of radish seed, radix bupleuri 25
Part, 30 parts of the coptis, 15 parts of Radix Angelicae Sinensis.
4. composite feed additive according to claim 1, which is characterized in that the chitosan quaternary ammonium salt is respectively by molecular weight
With mass ratio it is 1~3 for 800~1200,2000~2500,40000~60000 chitosan quaternary ammonium salt:1~3：1~3 group
At.
5. composite feed additive according to claim 4, which is characterized in that the chitosan quaternary ammonium salt is respectively by molecular weight
With mass ratio it is 1~2 for 900~1100,2100~2300,45000~55000 chitosan quaternary ammonium salt:1~2:1~2 group
At.
6. composite feed additive according to claim 5, which is characterized in that the chitosan quaternary ammonium salt is respectively by molecular weight
Chitosan quaternary ammonium salt for 1000,2200 and 50000 is 1 in mass ratio:1:1 composition.
7. composite feed additive according to claim 1, which is characterized in that the chitosan quaternary ammonium salt and Chinese medicinal component
Mass ratio is 1:2.
8. the preparation method of any composite feed additive of claim 1~7, which is characterized in that choose each in formula
Taste Chinese medicine removes the impurity of drug and non-medicinal effects respectively, ensures that medicinal effects water content is less than 10%, and according to formula
Amount mixing crushes, crosses 100~200 mesh sieve；Then with chitosan quaternary ammonium salt mixing, be drying to obtain the composite feed additive.
9. additive amount of any composite feed additive of claim 1~7 in pannage is the 1~2% of gross mass.
10. the application of composite feed additive according to claim 9, which is characterized in that the composite feed additive exists
Additive amount in pannage is the 1.5% of gross mass.
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