CN105166420A - Adsorption antidote capable of eliminating harm done by mycotoxins to livestock - Google Patents
Adsorption antidote capable of eliminating harm done by mycotoxins to livestock Download PDFInfo
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- CN105166420A CN105166420A CN201510660928.7A CN201510660928A CN105166420A CN 105166420 A CN105166420 A CN 105166420A CN 201510660928 A CN201510660928 A CN 201510660928A CN 105166420 A CN105166420 A CN 105166420A
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Abstract
The invention provides a toxin adsorption antidote capable of eliminating harm done by mycotoxins to livestock. The toxin adsorption antidote is prepared from 45-55% of modified attapulgite, 20-28% of modified montmorillonite, 5-10% of lignocelluloses, 5-15% of yeast cell walls, 1-2% of multi-vitamin micro-mineralization nutritious supplementary and 3-5% of functional extract superpacket. The toxin adsorption antidote can adsorb common mycotoxins, including aflatoxin, zearalenone, vomitoxin, ochratoxin and fumonisins, in feed so as to reduce the harm done by mycotoxins to animals; meanwhile, adsorption detoxication function is realized through nutrition enhancement and immunity improvement of livestock, and livestock breeding effect is improved.
Description
Technical field
The invention belongs to animal husbandry and feed gas defence detoxification technique field, be specifically related to a kind of mycotoxin of eliminating and domestic animal produced to the toxin Adsorptive ansidoie endangered.
Background technology
The cereal in the whole world annual about 25% is subject to the pollution of known mycotoxin.Mycotoxin common at present has aflatoxin, zearalenone, vomitoxin, fumonisin, ochratoxin etc.The mycotoxin that feed industry Raw and feed mold produce can reduce growth performance and immunity of organisms, the increase death rate of animal, causes huge economic loss.Aflatoxin produces damage to liver, and can have a direct impact cellular immunity and humoral immunity, zearalenone toxin then causes immunosupress simultaneously, and macrophage activity reduces, and causes breeding stock reproductive performance to decline.Vomitoxin produces damage to animal alimentary canal, and livestock and poultry feed intake is declined vomiting phenomenon even occurs, these produce huge economic loss to livestock.
It is the effective way reducing toxin harm that minimizing mycotoxin enters in animal body.At present conventional method has the physisorphtion of the alumino-silicates such as montmorillonite, charcoal absorption, chemical detoxication, enzyme process biodegradation and yeast cell wall Immune-enhancing effect and absorption method.Alumino-silicate series products only has suction-operated (Dvorska, 2001) to aflatoxin, but can produce interference to the utilization of amino acid and mineral matter simultaneously, is unfavorable for the absorption of nutriment; Activated carbon is proved external effectively invalid in body, and adsorbs nutriment equally; Chemical detoxication process destroys as the chemical substance such as ammoniacal liquor, oxidant can produce vitamin, and the security of feed and palatability are also influenced, and contratoxin detoxification treatment, adsorption effect are undesirable.For use acid, alkali, organic solvent or other intercalation processing modified aluminosilicate product then because having the existence of the modifying chemical such as alkali, machine solvent methanol, dimethyl sulfoxide (DMSO), also there is potential risk, and for the poor (CN103752263 of adsorption effect of vomitoxin; CN201310040205.8; CN201210333713.0).Toxin just starts absorption and enters in body when entering oral cavity, in 30min, the toxin of 80% has entered in body, and enzyme product plays a role and needs suitable temperature, body fluid system and acid or alkali environment, in animal body, complex environment causes the toxin degradation efficiency of single enzyme complex enzyme alive low, toxin when not being able to do in time through enzymolysis processing major part enter (CN101720848A) in animal body, so the limited efficiency of enzymatic isolation method.
Consider the otherness of the polarity of lps molecule, molecular weight, space structure and distribution of charges, diversity etc., conventional endotoxin adsorbent has certain limitation.Therefore obtained efficiently by the screening of contratoxin adsorbent material, the material that merges various different efficacies, the mycotoxin adsorption antidote of wide spectrum has using value very much.There are supplemental acid agent or the patented product such as Rhizoma Atractylodis Macrocephalae extract, active bacteria formulation (CN201410564991.6 in modified aluminosilicate at present; CN201410420558.5; CN201410852825.6), these patents carry out adsorbing and improving from enzymolysis in raising digestion, body or Immune-enhancing effect aspect respectively, but all fail to realize comprehensive detoxification releasing toxin.
Summary of the invention
For solving the technical problem that above-mentioned mold toxin sorbent removing toxic substances aspect exists, the invention provides a kind of compound toxin Adsorptive ansidoie, mycotoxin can be eliminated all sidedly on the harm of domestic animal and impact.
For realizing above-mentioned target, technical scheme provided by the invention is: a kind of toxin Adsorptive ansidoie eliminated mycotoxin and endanger domestic animal, according to percetage by weight, described toxin Adsorptive ansidoie is attapulgite modified by 45%-55%, 20%-28% is modified montmorillonite used, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 5%-10% lignocellulosic, 5%-15% yeast cell wall, 1%-2% and the functional extract superpacket of 3%-5% form.
Wherein, described toxin Adsorptive ansidoie is made up of 55% attapulgite modified, 20% modified montmorillonite used, 10% lignocellulosic, 10% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 3%.
Wherein, described toxin Adsorptive ansidoie is made up of 45% attapulgite modified, 25% modified montmorillonite used, 8% lignocellulosic, 15% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 3%.
Wherein, described toxin Adsorptive ansidoie is made up of 50% attapulgite modified, 28% modified montmorillonite used, 10% lignocellulosic, 5% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 5%.
Wherein, the composition of multidimensional micro-ore deposit nutritious supplementary pharmaceutical comprises choline, V
b1, V
b5, V
c, V
eand S
e(selenium), zinc methionine.
Wherein, functional extract superpacket is made up of chitosan oligomer, cinnamon essential oil, fruit of Chinese magnoliavine essential oil, Herba Silybi mariani powder, grape pip and carrier.
The present invention also provides a kind of and eliminates the preparation method of mycotoxin to the toxin Adsorptive ansidoie that domestic animal endangers, and step is as follows: a), preparation multidimensional micro-ore deposit nutritious supplementary pharmaceutical and functional extract superpacket; B), according to ratio micro-for obtained multidimensional ore deposit nutritious supplementary pharmaceutical and functional extract superpacket joined and carry out 2-3min in lignocellulosic and yeast cell wall raw material and fully mix; C), proportionally 2-3min is fully mixed by attapulgite modified and modified montmorillonite used; D), according to ratio by b) and c) obtained semi-finished product fully mix, incorporation time 5-8min, forms homogeneous finished product and carries out packing.
Specific as follows:
The present invention also provides and can eliminate the using method of mycotoxin to the toxin Adsorptive ansidoie that domestic animal endangers, described toxin Adsorptive ansidoie can use in pig, fowl, ox and rabbit daily ration, pollution condition according to daily ration toxin can be added as one sees fit, preventive dose at 1-2kg/ ton complete diet pellet, dosage 2-4kg/ ton complete diet pellet.
Mostly common endotoxin adsorbent is with alumino-silicate and yeast cell wall for main component, additional enzymes preparation or extract again, but confirm through laboratory research, such endotoxin adsorbent major part is for ZEN (zearalenone) part effectively, substantially invalid for DON toxin (vomitoxin).Comprise lignocellulosic in constituent of the present invention, it can adsorb, the ZEN that is coupled (zearalenone) and DON toxin (vomitoxin), thus there is the function not available for common endotoxin adsorbent.In addition, the present invention supplements multidimensional micro-ore deposit nutritious supplementary pharmaceutical, can help animal supplement the nutrients, anti-oxidant, functional extract superpacket can help the strong liver and expelling toxin of animal, promote immunity, therefore one aspect of the present invention passes through the absorption that ore deposit soil and yeast cell wall and lignocellulosic reduce vivotoxin, strengthen liver dispelling toxicity, detoxicating function by nutritional supplementation and plant extracts again on the other hand, thus more fully eliminate the impact of toxin for animal.
Beneficial effect of the present invention is:
(1) attapulgite modified and modified montmorillonite used in the present invention can effectively adsorption of aflatoxin, zearalenone, simultaneously because the structure of the two there are differences, in the preparation the two is first mixed the space structure that can improve alumino-silicate, reduce the present invention to the absorption of the macro-nutrients such as vitamin and mineral matter, avoid consequent multidimensional micro-ore deposit nutritional deficiency.
(2) yeast cell wall can strengthen the absorption to zearalenone, and zymosan effectively can promote human body immune function simultaneously, reduces and even eliminates toxin to the infringement of animal immune function.
(3) lignocellulosic can effectively adsorption of aflatoxin, zearalenone, fumonisin and vomitoxin, reaches more than 95%, reach more than 50% to vomitoxin adsorption rate to front 3 kinds of toxin adsorption rates.
(4) in the nutritional supplementation bag of multidimensional micro-ore deposit, zinc methionine, choline can provide methyl, ensure that body is because synthesizing the needs of increase in demand to methionine during tissue damage; V simultaneously
e, V
c, S
edeng vitamin, there is good antioxidant effect, effectively can eliminate the free radical that toxin-induced body produces, reduce damage animal being comprised to the histoorgan such as liver, alimentary canal, meet the nutritional need of animal.
(5) functional extract superpacket plays effect from anti-oxidant, Immune-enhancing effect, antibacterial and food calling aspect comprehensively.Wherein, cinnamon essential oil has good fungistatic effect, avoids the further growth of mould, and reducing toxin increases, and its distinctive fragrance can promote feed intake simultaneously; Fruit of Chinese magnoliavine essential oil and Herba Silybi mariani powder have good liver-invigorating detoxication effect, can the normal operation of effective guarantee liver function, and chitosan oligomer can strengthen human body immune function, improves animal health level, improves growth achievement; Grape pip has well anti-oxidant and Immune-enhancing effect effect equally.
The adsorbable feed of the present invention comprises aflatoxin, zearalenone, vomitoxin and ochratoxin and fumonisin at interior common mycotoxin, reduce mycotoxin to the harm of animal, simultaneously also by strengthening the nutrition of domestic animal, promoting animal immune ability and play adsorpting detoxication effect, improve livestock culturing achievement.
Detailed description of the invention:
Below in conjunction with specific embodiment mode, set forth the present invention further.Should be understood that these embodiments only for illustration of the present invention instead of limit the scope of the invention.In addition, after having read content of the present invention, those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within limited range of the present invention equally.
Eliminate the toxin Adsorptive ansidoie that mycotoxin endangers domestic animal, its implementation method and step are:
A), preparation multidimensional micro-ore deposit nutritious supplementary pharmaceutical, is specially choline, V
b1, V
b5, V
c, V
eand S
e, zinc methionine fully mixes 2-3min with maize cob meal carrier, obtains homogeneous multidimensional micro-ore deposit nutritious supplementary pharmaceutical;
B), function equipment extract superpacket, is specially chitosan oligomer, cinnamon essential oil, fruit of Chinese magnoliavine essential oil, Herba Silybi mariani powder and grape pip and ground silica carrier, fully mixes 2-3min, obtains homogeneous functional extract superpacket;
C), fully 2-3min is mixed with the modified montmorillonite used of 20%-28% according to predetermined formulation ratio by accounting for the attapulgite modified of system gross weight 45%-55%.Attapulgite modified is acid adding heat modification, and modified montmorillonite used is organically-modified.
D), multidimensional micro-ore deposit nutritious supplementary pharmaceutical obtained in a) and b) is mixed according to 3%-5% and the 5%-10% lignocellulose raw material of total system and 5%-15% zymosan fully according to the 1%-2% of total system, functional plants extract superpacket, incorporation time 2-3min.
E), according to attach ratios by c) and d) obtained semi-finished product fully mix, incorporation time is 5-8min, forms homogeneous finished product and carries out packing.
This toxin Adsorptive ansidoie can use in pig, fowl, ox and rabbit daily ration, and the pollution condition according to daily ration toxin can be added as one sees fit, preventive dose at 1-2kg/ ton complete diet pellet, therapeutic dose 2-4kg/ ton complete diet pellet.
Embodiment 1 ~ 3
1. calculate by weight percentage, this toxin Adsorptive ansidoie is made up of 55% attapulgite modified, 20% modified montmorillonite used, 10% lignocellulosic, 10% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 3%.Concrete processing sequence according to step a) to e) obtaining.
2. calculate by weight percentage, this toxin Adsorptive ansidoie is made up of 45% attapulgite modified, 25% modified montmorillonite used, 8% lignocellulosic, 15% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 5%.Concrete processing sequence according to step a) to e) obtaining.
3. calculate by weight percentage, this toxin Adsorptive ansidoie is made up of 50% attapulgite modified, 28% modified montmorillonite used, 10% lignocellulosic, 5% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 5%.Concrete processing sequence according to step a) to e) obtaining.
Embodiment 4, compliance test result
The product obtained by embodiment 2, through in-vitro simulated adsorption test, reaches more than 95% to the adsorption rate of aflatoxin, zearalenone, fumonisin in its 1 hour, reaches 50% to the adsorption rate of vomitoxin.
The adsorption rate of table 1 embodiment 2 pairs of mycotoxins
| Toxin | Aflatoxin | Zearalenone | Fumonisin | Vomitoxin |
| Adsorption effect in 30 minutes | 98％ | 75％ | 80％ | 35％ |
| Adsorption effect in 1 hour | 100％ | 95％ | 100％ | 50％ |
The product simulation gastrointestinal tract environment obtained by embodiment 2 finds the impact of its adsorption rate, under pH3.5 gastric fluid conditions and pH6.8 duodenal juice environment, Adsorptive ansidoie and toxin hatch 1h at 37 DEG C, endotoxin level in system significantly declines, wherein more than 95% is reached to the adsorption rate of aflatoxin, zearalenone, fumonisin, under pH3.5 gastric juice and pH6.8 duodenal juice condition, 60% and 52% are reached respectively to the adsorption rate of vomitoxin.Adsorption effect is fine, essentially eliminates the impact of toxin.
Table 2 embodiment 2 is to the adsorption rate of mycotoxin in different fluid environment
| Toxin | Aflatoxin | Zearalenone | Fumonisin | Vomitoxin |
| PH3.5 gastric juice environment adsorption effect | 100％ | 98％ | 100％ | 60％ |
| PH6.8 duodenal juice adsorption effect | 100％ | 95％ | 99％ | 52％ |
The adsorbent of the present invention obtained by embodiment 3 confirms at 690 meat rabbit results of animals, and toxin Adsorptive ansidoie of the present invention effectively can improve death rate, the raising colony regularity of animal, improves growth achievement.
Table 3 toxin Adsorptive ansidoie is in the experimental result of 37-70 age in days meat rabbit
Note; Control group is the experimental group not using endotoxin adsorbent
As can be seen here, the adsorbable Mycotoxins in Feed of the present invention, reduces the absorption of toxin in body, and improves animal health level by the liver-invigorating detoxication of nutritious supplementary pharmaceutical and functional extract superpacket, immunological enhancement, improves cultivation achievement.
The present invention utilizes modified aluminosilicate and yeast cell wall, lignocellulosic reduces aspergillus flavus, zearalenone, vomitoxin, uptake in the body of fumonisin etc., make up toxin by adding nutritious supplementary pharmaceutical animal alimentary canal absorption function is declined the negative effect caused, by yeast cell wall immune polysaccharide, the immunological enhancement of chitosan oligomer, utilize the antibacterial of cinnamon essential oil and food calling effect, fruit of Chinese magnoliavine essential oil, the hepatoprotective effect of milk thistle, strengthening liver is to the dispelling toxicity, detoxicating function of mycotoxin, and grape pip, vitamin E, vitamin C, the antioxidation of Se, full protection body, cut down the harmful effect even eliminated mycotoxin and Livestock Production is caused, improve animal-breeding achievement, increase economic efficiency.In addition, the present invention is obvious for the adsorption effect of toxin, but cost is quite cheap, is very suitable for cultivation dealer and uses.
Be more than the description to the embodiment of the present invention, by the above-mentioned explanation to the disclosed embodiments, professional and technical personnel in the field realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (8)
1. the toxin Adsorptive ansidoie can eliminated mycotoxin and domestic animal is endangered, it is characterized in that, percentage by weight, described toxin Adsorptive ansidoie is attapulgite modified by 45%-55%, 20%-28% is modified montmorillonite used, 5%-10% lignocellulosic, 5%-15% yeast cell wall, 1%-2% multidimensional micro-ore deposit nutritious supplementary pharmaceutical and the functional extract superpacket of 3%-5% form.
2. can eliminate the toxin Adsorptive ansidoie that mycotoxin endangers domestic animal as claimed in claim 1, it is characterized in that, described toxin Adsorptive ansidoie is made up of 55% attapulgite modified, 20% modified montmorillonite used, 10% lignocellulosic, 10% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 3%.
3. can eliminate the toxin Adsorptive ansidoie that mycotoxin endangers domestic animal as claimed in claim 1, it is characterized in that, described toxin Adsorptive ansidoie is made up of 45% attapulgite modified, 25% modified montmorillonite used, 8% lignocellulosic, 15% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 5%.
4. can eliminate the toxin Adsorptive ansidoie that mycotoxin endangers domestic animal as claimed in claim 1, it is characterized in that, described toxin Adsorptive ansidoie is made up of 50% attapulgite modified, 28% modified montmorillonite used, 10% lignocellulosic, 5% yeast cell wall, multidimensional micro-ore deposit nutritious supplementary pharmaceutical of 2% and the functional extract superpacket of 5%.
5. the toxin Adsorptive ansidoie that the mycotoxin eliminated as described in as arbitrary in Claims 1 to 4 endangers domestic animal, it is characterized in that, described multidimensional micro-ore deposit nutritious supplementary pharmaceutical is by choline, V
b1, V
b5, V
c, V
eand S
e, zinc methionine and carrier composition.
6. the toxin Adsorptive ansidoie that the mycotoxin eliminated as described in as arbitrary in Claims 1 to 4 endangers domestic animal, it is characterized in that, described functional extract superpacket is made up of chitosan oligomer, cinnamon essential oil, fruit of Chinese magnoliavine essential oil, Herba Silybi mariani powder, grape pip and carrier.
7. can eliminate the preparation method of mycotoxin to the Adsorptive ansidoie that domestic animal endangers, it is characterized in that, the step of described preparation method is as follows:
A), multidimensional micro-ore deposit nutritious supplementary pharmaceutical and functional extract superpacket is prepared; B), according to ratio multidimensional micro-ore deposit nutritious supplementary pharmaceutical obtained in a) and functional extract superpacket joined and carry out 2-3min in lignocellulosic and yeast cell wall raw material and fully mix; C), 2-3min is fully mixed attapulgite modified and modified montmorillonite used according to predetermined formulation ratio; D), according to attach ratios by b) and c) obtained semi-finished product fully mix, incorporation time 5-8min, forms homogeneous finished product and carries out packing.
8. can eliminate the using method of mycotoxin to the Adsorptive ansidoie that domestic animal endangers for one kind, it is characterized in that, described toxin Adsorptive ansidoie can use in pig, fowl, ox and rabbit daily ration, pollution condition according to daily ration toxin can be added as one sees fit, preventive dose at 1-2kg/ ton complete diet pellet, therapeutic dose 2-4kg/ ton complete diet pellet.
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