CN103719616A - Feed for treating bloody flux of pigs and preparation method of feed - Google Patents
Feed for treating bloody flux of pigs and preparation method of feed Download PDFInfo
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Abstract
The invention discloses a feed for treating bloody flux of pigs and a preparation method of the feed. The feed comprises the following raw materials: flour, millet, egg yolk, lotus root starch, lotus seeds, vitamin C, a microecological preparation and a traditional Chinese medicine additive. The feed disclosed by the invention has the beneficial effects that the traditional Chinese medicine additive is added and achieves the treatment principles of clearing away heat and toxic materials, dispelling dampness, warming middle Jiao, regulating qi-flowing for activating stagnancy, and cooling blood for hemostasis; the traditional Chinese medicine additive interacts with other raw materials of the feed, and thus the feed for treating the bloody flux of pigs has the advantages that the treatment course is short, no medicine residues, the toxicity is reduced, the curative rate is high, the immunity of the pigs is enhanced, relapse is unlike to happen after healing, the cost is low and the like.
Description
Technical field
The present invention relates to field of feed, particularly a kind of feed that is used for the treatment of pig bloody flux and preparation method thereof.
Background technology
Pig bloody flux, claims again swine dysentery, is that cause pig by pathogenic swine dysentery Serpulina a kind of endangers serious enteric infectious disease.Take colorectal mucosa Catarrhal, hemorrhagic and gangrenous inflammation as feature.Clinical manifestation for becoming thin, mucus or hemorrhagic diarrhea.
Swine dysentery Serpulina is that Serpulina belongs to member, incorporates in the past Treponema into.Long 6～8.5 microns of thalline, wide 0.3～0.37 micron, mostly be 4～6 bendings, 5～6 bendings that have, two ends are sharp-pointed, and shape is as two wild goose wing, Gram-negative.Fresh pathological material of disease is visible active conveyor screw activity under dark-field microscope.Cause of disease to external world environment has stronger resistance, in ight soil, can survive 61 days 5 ℃ time, can survive 7 days for 25 ℃, in soil, can survive 102 days for 4 ℃.But not strong to disinfectant resistance, common disinfectant all can kill it rapidly.
Sick pig and the pig that carries disease germs are the main infections sources.The rehabilitation pig discharge of bacteria that can carry disease germs reaches the several months.Alimentary canal is only route of infection, by the medium such as feed, drinking-water, apparatus, personnel, animal and environment polluting, causes indirect infection.Infected pigs, the equal easy infection of pig at various kinds and age, but many with pig morbidity in 7～12 week age.Other animals do not infect.This sick popular nothing is obviously seasonal.The popular initial stage is got acute process more, is subacute and chronic more later, once the sustainable constantly generation repeatedly of passing on a skill of craft to others is difficult for eradicating.
This disease incubation period is about 2 days to 3 months, average out to 1～2 week.To have loose bowels, ight soil is congee sample or water sample, and including mucus, mucous membrane or blood is feature.There are hyperthermia and stomachache phenomenon.The also performance that the course of disease is long is dewatered, is become thin and incoordination.According to course of disease length, can divide acute, subacute and chronic three types.
The initial stage of breaking out is acute more, subsequently take subacute and chronic as main, and the most acute die by visitation of God.Acute disease temperature of pig body raises and reaches 40～40.5 ℃, poor appetite.Diarrhoea, start the yellow soft stool to grey of row, then row is contained the just rare of a large amount of mucus band traces of blood, rear passage of watery stools, and the fragment that contains blood, mucus and white stickiness fibrinous exudate.Sick pig hogback, presents colic symptoms sometimes.Sick pig dehydration, weak, become thin.Blood is sticky, and leukocyte count increases, neutrophil cell shift to left.Large enterorrhagia, serious generation anaemia.Subacute and the chronic state of an illness is lighter, diarrhea, excrement band mucus and blood, and course of disease elder's progressive emaciation, case fatality rate is low, retarded growth.
Western modern medicine treatment pig bloody flux, medicine treatment, as LIJUNJING (MAQO, 3-methyl-acetyl group-quinoline is disliked woods-Isosorbide-5-Nitrae-dioxide) 5mg/kg, for oral administration, every day 2 times, serveing on 3 is a course for the treatment of, or by 0.5% LIJUNJING solution 0.5ml/kg, intramuscular injection; The multiple antibacterials such as the pyridine of diformazan nitro miaow, neomycinsulphate, furazolidone, cillimycin, Cyclomycin family antibiotic have certain curative effect.But this disease is controlled rear easy recurrence, and resultant anti-stress, the physiological function such as anti-disease and food meat quality (quality) decline greatly, medicament residue is constantly rising.But traditional Chinese medicine not only has the advantage of Western medicine, and cure rate is high, pollution-free, can strengthen pig immunity, after curing, is difficult for recurrence, and cost price is individual cheap.Therefore, Chinese herbal medicine is aspect treatment pig bloody flux disease, and application natural goods feed addictive is of great practical significance.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of feed that is used for the treatment of pig bloody flux, and treatment pig bloody flux has short treating period, drug residue free, and cure rate is high, strengthens pig immunity simultaneously, is difficult for the advantage of recurrence after curing.
In order to realize foregoing invention object, the invention provides a kind of feed that is used for the treatment of pig bloody flux, described feed comprises following raw material: flour, millet, egg yolk, lotus root starch, lotus seeds, vitamin C, probiotics and Chinese medicine additive.
Described feed is comprised of the raw material of following parts by weight: flour 50-70 weight portion, millet 40-60 weight portion, egg yolk 10-30 weight portion, lotus root starch 20-30 weight portion, lotus seeds 10-20 weight portion, vitamin C 5-8 weight portion, probiotics 3-8 weight portion and Chinese medicine additive 5-11 weight portion.
Described feed is comprised of the raw material of following parts by weight: flour 65 weight portions, millet 54 weight portions, egg yolk 15 weight portions, lotus root starch 27 weight portions, lotus seeds 13 weight portions, vitamin C 6 weight portions, probiotics 7 weight portions and Chinese medicine additive 8 weight portions.
Described Chinese medicine additive comprises following raw medicinal material: the dried immature fruit of citron orange, chickweed, the Chinese bulbul, rotten inferior, shepherd's purse, blue pig ear, lychee exocarp, forrest bugle herb, hairyvein agrimony, Artemisia anomala, the arched end, dandelion, evergreen, the Radix Astragali, fern fiber crops, dried orange peel, dalbergia wood, tinosporae, Herba Cyathulae Prostratae and maggot.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 15-30 weight portion, chickweed 10-20 weight portion, Chinese bulbul 10-20 weight portion, rotten inferior 10-20 weight portion, shepherd's purse 15-25 weight portion, blue pig ear 10-20 weight portion, lychee exocarp 10-20 weight portion, forrest bugle herb 10-15 weight portion, hairyvein agrimony 10-20 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 10-20 weight portion, Radix Astragali 20-30 weight portion, fern fiber crops 10-20 weight portion, dried orange peel 15-25 weight portion, dalbergia wood 15-25 weight portion, tinosporae 10-20 weight portion, Herba Cyathulae Prostratae 10-20 weight portion and maggot 10-20 weight portion.
Described feed is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 18-27 weight portion, chickweed 13-17 weight portion, Chinese bulbul 12-17 weight portion, rotten inferior 15-20 weight portion, shepherd's purse 18-23 weight portion, blue pig ear 11-18 weight portion, lychee exocarp 13-20 weight portion, forrest bugle herb 13-15 weight portion, hairyvein agrimony 12-18 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 14-20 weight portion, Radix Astragali 25-30 weight portion, fern fiber crops 12-20 weight portion, dried orange peel 17-23 weight portion, dalbergia wood 15-23 weight portion, tinosporae 10-15 weight portion, Herba Cyathulae Prostratae 10-16 weight portion and maggot 14-20 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the dried immature fruit of citron orange 23 weight portions, chickweed 15 weight portions, the Chinese bulbul 14 weight portions, rotten inferior 17 weight portions, shepherd's purse 21 weight portions, blue pig ear 15 weight portions, lychee exocarp 17 weight portions, forrest bugle herb 14 weight portions, hairyvein agrimony 15 weight portions, Artemisia anomala 15 weight portions, weight portion of the arched ends 15, dandelion 21 weight portions, evergreen 17 weight portions, the Radix Astragali 28 weight portions, fern fiber crops 16 weight portions, dried orange peel 20 weight portions, dalbergia wood 19 weight portions, tinosporae 13 weight portions, Herba Cyathulae Prostratae 13 weight portions and maggot 17 weight portions.
Described Chinese medicine additive also comprises: umbellate pore furgus, Amomum cardamomum, the bighead atractylodes rhizome, Poria cocos and Chinese yam.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 15-30 weight portion, chickweed 10-20 weight portion, Chinese bulbul 10-20 weight portion, rotten inferior 10-20 weight portion, shepherd's purse 15-25 weight portion, blue pig ear 10-20 weight portion, lychee exocarp 10-20 weight portion, forrest bugle herb 10-15 weight portion, hairyvein agrimony 10-20 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 10-20 weight portion, Radix Astragali 20-30 weight portion, fern fiber crops 10-20 weight portion, dried orange peel 15-25 weight portion, dalbergia wood 15-25 weight portion, tinosporae 10-20 weight portion, Herba Cyathulae Prostratae 10-20 weight portion, maggot 10-20 weight portion, umbellate pore furgus 10-15 weight portion, Amomum cardamomum 10-16 weight portion, bighead atractylodes rhizome 15-20 weight portion, Poria cocos 15-20 weight portion and Chinese yam 15-20 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 17-27 weight portion, chickweed 12-18 weight portion, Chinese bulbul 11-17 weight portion, rotten inferior 13-20 weight portion, shepherd's purse 17-21 weight portion, blue pig ear 12-18 weight portion, lychee exocarp 12-17 weight portion, forrest bugle herb 12-14 weight portion, hairyvein agrimony 12-17 weight portion, Artemisia anomala 13-20 weight portion, arched end 10-16 weight portion, dandelion 17-22 weight portion, evergreen 12-17 weight portion, Radix Astragali 22-26 weight portion, fern fiber crops 12-17 weight portion, dried orange peel 15-25 weight portion, dalbergia wood 15-25 weight portion, tinosporae 13-17 weight portion, Herba Cyathulae Prostratae 12-16 weight portion, maggot 10-20 weight portion, umbellate pore furgus 10-15 weight portion, Amomum cardamomum 13-16 weight portion, bighead atractylodes rhizome 15-17 weight portion, Poria cocos 17-20 weight portion and Chinese yam 15-18 weight portion.
Described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the dried immature fruit of citron orange 23 weight portions, chickweed 16 weight portions, the Chinese bulbul 14 weight portions, rotten inferior 18 weight portions, shepherd's purse 19 weight portions, blue pig ear 15 weight portions, lychee exocarp 14 weight portions, forrest bugle herb 13 weight portions, hairyvein agrimony 15 weight portions, Artemisia anomala 16 weight portions, weight portion of the arched ends 13, dandelion 19 weight portions, evergreen 14 weight portions, the Radix Astragali 24 weight portions, fern fiber crops 15 weight portions, dried orange peel 21 weight portions, dalbergia wood 19 weight portions, tinosporae 15 weight portions, Herba Cyathulae Prostratae 14 weight portions, maggot 15 weight portions, umbellate pore furgus 13 weight portions, Amomum cardamomum 15 weight portions, the bighead atractylodes rhizome 16 weight portions, Poria cocos 18 weight portions and Chinese yam 16 weight portions.
The preparation method of described Chinese medicine additive comprises the following steps:
According to ratio of weight and number, take all raw medicinal materials, first raw medicinal material is put into the ethanol that 10 times of amount determining alcohols are 85%, heating and refluxing extraction twice, each 45 minutes, extract active ingredient, by standing the merging of extracted twice liquid, the dregs of a decoction are standby; The dregs of a decoction are added to 10 times of water gagings, and heating and refluxing extraction 3 times, each 1 hour, merges No. 3 extracts; Decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.06; The large pore resin absorption column wash-out twice that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol eluate, removes solvent, obtains raw material liquid; To the starch that adds raw material liquid weight 5% in raw material liquid, after stirring, dry, grind into powder.
Wherein, probiotics is one or both in bacillus and lactic acid bacteria.
In order better to realize foregoing invention object, the invention provides a kind of preparation method of the feed that is used for the treatment of swine dysentery, described preparation method comprises the following steps:
(1) broken step: take by weight percentage millet, egg yolk and lotus seeds input pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into flour, lotus root starch, vitamin C, probiotics and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: feed of the present invention contains Chinese medicine and adds Egyptian, Chinese medicine additive in clearing heat and detoxicating, clearing damp temperature, regulating qi-flowing for activating stagnancy, cooling blood and hemostasis be as principle of reatment, interact with other feedstuffs, in treatment pig bloody flux, there is short treating period, drug residue free, reduce toxicity, cure rate is high, strengthens pig immunity, after curing, be difficult for recurrence, low cost and other advantages.
The specific embodiment
Dysentery is row epidemic disease poison during because of diseases caused by external factors, internal injury diet and cause heresy and accumulate intestines internal organs, and stagnation of QI-blood, conduction mistake department, with abdominal pain diarrhea, tenesmus, to arrange red white pus and blood stool be main clinical manifestation has communicable exogenous diseases.In < <, through > >, claim this disease for " intestines trip ", the aspects such as this sick cause of disease, symptom, prognosis are all discussed to some extent, as bright in the lunar sun of < < Plain Questions opinion > > says: " food drink does not save; daily life is person frequently; the moon is subject to it ... pathogens in YIN parts of the body being apt to enter five ZANG-organs ... dirty film is full inaccessible; under let out for supper, for a long time for intestines are debated." point out that this cause of disease is relevant with eating and drinking without temperance.< < Plain Questions, to very discussing greatly > >, say: " excessive victory of fire ... the sick bloody and purulent stool of the people ... stomachache dark urine, very bloody stool." point out that this sick cause of disease is relevant with weather, symptom is stomachache, just lower red white.The lower sharp abnormal pulse of the Chinese < < Synopsis Golden Chamber vomiting sound of vomiting is demonstrate,proved and is controlled > > by this disease and have loose bowels and is collectively referred to as " lower profit ", formulate different baitouweng decoction and the Taohua Tangs of fever and chills and treated this disease, started the diagnosis and treatment of dysentery, two sides always by later age doctor liked use.The < < of Sui General Treatise on the Cause and Symptoms of Diseases > > has " dysentery ", " bloody flux ", " purulent dysentery ", " hot dysentery " etc. more than 20 to plant the record of dysentery time, and this sick clinical manifestation and the cause of disease, the interpretation of the cause, onset and process of an illness are had to more deep understanding.The < < of Tang Essential Recipes for Emergent Use Worth A Thousand Gold > > claims this disease for " under stagnant ", Song < < Yan's prescriptions for succouring sick > > formally enables the name of disease of " dysentery ": " the so-called dysentery person of the present; be also under ancient what is called is stagnant ", use till today always.Gold dollar period, < < danxi's experiential therapy > > explicitly points out this disease and has popularity, infectiousness: " epidemic disease is made dysentery; within one of a side; infect up and down similar ", and the cause of disease of discussing dysentery is take " damp and hot as this ".The Qing Dynasty, there is dysentery monograph, as < < dysentery opinion > > < < dysentery card is discussed > > etc., theoretical and the clinical system summary that carried out to dysentery, academicly also innovation to some extent.
Chinese veterinarian thinks, eliminating evil basic pathogenesis of leading stagnant dysentery is that perverse trend is stopped up in stagnant intestines, only has the heap soil or fertilizer over and around the roots of eliminating pathogens stagnant, could recover the duty of intestines internal organs conduction, avoids that qi and blood is to stagnate, and the damage of adipose membrane blood network, therefore the method for effecting a permanent cure.Therefore, remove the stagnant heresies such as damp and hot, epidemic disease is malicious, cold long-pending, diet in intestines rather important.Commonly use in clearing damp, heat-clearing, temperature, detoxify, help digestion, lead stagnant, logical inferior method, to reach the eliminating evil stagnant object of leading.Regulating the qi flowing in the channels and blood regulating the qi flowing in the channels and blood are the sluggish qi and bloods of smooth and easy intestines internal organs, and the fat purulence of dispelling corruption recovers enteron aisle transmitting function, promote the adipose membrane blood network of damage to repair as early as possible, to improve the clinical symptoms such as stomachache, tenesmus, diarrhea purulence blood.Said as Liu's interchannel: " regulating the qi flowing in the channels is heavy from removing afterwards, and promoting circulation of blood is just purulence self-healing ".The present invention in clearing heat and detoxicating, clearing damp temperature, regulating qi-flowing for activating stagnancy, cooling blood and hemostasis be as principle of reatment, a kind of feed that is used for the treatment of pig bloody flux that contains Chinese medicine additive is provided, and Chinese medicine additive comprises following raw medicinal material: the dried immature fruit of citron orange, chickweed, the Chinese bulbul, rotten inferior, shepherd's purse, blue pig ear, lychee exocarp, forrest bugle herb, hairyvein agrimony, Artemisia anomala, the arched end, dandelion, evergreen, the Radix Astragali, fern fiber crops, dried orange peel, dalbergia wood, tinosporae, Herba Cyathulae Prostratae and maggot.
Wherein, the pharmacological property of each raw medicinal material is as follows:
The dried immature fruit of citron orange: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: relieving stagnant Qi disappears long-pending, the loose ruffian of reducing phlegm.For in stagnant, stop, the full distending pain of ruffian, rushes down after dysentery heavyly, suffer from constipation, and the stagnant vapour lock obstruction of qi in the chest of phlegm, accumulation of pathogens in chest; Gastroptosis, prolapse of the anus, the prolapse of uterus.
Chickweed: sweet, sour, cool.Function cures mainly: clearing heat and detoxicating, and blood-activating analgetic, lactagogue.For enteritis, dysentery, hepatitis, appendicitis, postpartum blood stasis stomachache, uterine contractile pain, toothache, graying of hair, agalactia, mastitis, traumatic injury, sore swollen toxin.
The Chinese bulbul: bitter, cold in nature; Return stomach, large intestine channel; Have clearing heat and detoxicatingly, remove heat from the blood and relieve diarrhea, the effect of removing dampness and destroying parasites; Cure mainly pyrotoxic dysentery disease, nosebleed epistaxis, bleeding, under band, pruritus vulvae, carbuncle sore, scrofula antibacterial action, the fresh juice of the Chinese bulbul, decoction, ethanol extract equal the external obvious antibacterial action that all has, and can suppress the growth of staphylococcus aureus, Pseudomonas aeruginosa, shigella dysenteriae, hay bacillus, typhoid bacillus, detection of Salmonella etc.To corynebacterium diphtheriae, staphylococcus, streptococcus, Escherichia coli, tubercle bacillus effect in addition, the Chinese bulbul and compound thereof all have inhibitory action to dermatophyte, saccharomycete, trypanosome, Candida albicans etc. as baitouweng decoction to Anemonin.The Chinese bulbul have stronger killing fungus effect.The Chinese bulbul also has slight inhibitory action to small white mouse influenza infection, and its infusion can extend the time-to-live of influenza virus infection PR8 strain mouse, alleviates lung inflammation.Chinese bulbul ethanol extract has calmness, analgesic activity.
Rotten inferior: bitter, puckery, cold.Function cures mainly: clearing heat and detoxicating, and swelling and pain relieving, astringing to arrest bleeding.For dysentery, appendicitis, Tripterygium wilfordii Poisoning; Burn and scald is controlled in external application, lymphnoditis, the carbuncle sore furuncle that swells, venomous snake bite, traumatism and bleeding.
Shepherd's purse: pungent, temperature.Enter lung, stomach, double enter kidney.Function cures mainly: the open-minded phlegm of a surname's lung, Wen Zhongli gas.Control in cold drink and contain, cough phlegm is stagnant, and chest diaphragm is full vexed.1. < < does not record > >: " main except kidney perverse trend, sharp nine orifices, improve visual and auditory acuity, in peace, takes in temperature for a long time." 2. < < dietetic materia medica > >: " master coughs contrary, lower gas, improving eyesight, the face wind of decaptitating.The open-minded phlegm of " 3. < < detailed outline > >: " logical lung, sharp diaphragm appetizing."
Blue pig ear: hardship, cool.Function cures mainly: clearing heat and detoxicating, and dampness removing, cough-relieving, and stomach preventing or arresting vomiting, stagnation resolvation.
Lychee exocarp: hardship; Cool.Thoughts of returning home warp.Function cures mainly: dehumidifying is dysentery only; Hemostasis.Main dysentery; Metrorrhagia; Eczema.
Forrest bugle herb: bitter; Pungent; Cold in nature.Function cures mainly: thermolysin; Promoting diuresis for stranguria; Blood stasis removing analgesic; Expelling parasite.Main cough with lung heat; Abscess of throat; Dysentery; Jaundice; Heat is drenched; Oedema; Mastitis; Vasculitis; Carbuncle sore furuncle; Traumatic injury; Traumatism and bleeding; Roundworm disease.
Hairyvein agrimony: bitter, puckery, flat.The thoughts of returning home, Liver Channel.Function cures mainly: hold back hemostasis, preventing malaria, only dysentery, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, bloody flux, de-power internal lesion caused by overexertion, carbuncle sore tumefacting virus, under pruritus vulvae band.1. for hemostasis: hairyvein agrimony and by the stem of hairyvein agrimony, the agrimonine that leaf extracts, its anastalsis confirmed by clinical, and makes already various formulations and be widely used in various hemorrhage illnesss.Again hairyvein agrimony is made to styptic powder in recent years, hemorrhage or oozing of blood (comprising encephalic operation, thoracic and abdominal operation) during for traumatism and bleeding, internal organ operation, according to the clinical observation of 20 examples, all hemostasis in 1～2 minute.2. treat trichomonas vaginitis: with the cauline leaf of wolf's fang grass, make 200% concentrated decocting liquid.Used time is first used vaginal speculum vaginal dilation, with geramine cotton balls, thoroughly shampoos vaginal wall comprehensively, then the full cotton balls that dips in wolf's fang grass liquid is smeared to whole vaginal wall equably.Filling in satisfies again dips in the large tampon of special band line of wolf's fang grass liquid, places after 3～4 hours, advises patient to take out voluntarily.Be for 7 times a course for the treatment of every day 1 time.According to the observation of 40 examples, the cure rate of 3 courses for the treatment of reaches 92.5%, 3 equal feminine genders of microscopy Trichomonas vaginalis; All the other cases also take a favorable turn.General medication about 1 week, local itch is alleviated or is disappeared, and leukorrhea significantly reduces.3. treat the infectious food poisoning of Halophiles.4. rescue the dissociation that Keshan disease causes: after determining diagnosis, with 5～10 milligrams of agrimonines, add directly intravenous injection in 20～40 milliliters of 25～50% glucose, if desired can be every 3～4 hours repeated application.Injection must be slowly, and must not be less than 10 minutes inject time.Clinic trial 6 examples, 4 examples transfer sinus rhythm to after treatment, and clinical symptoms are also improved rapidly; 2 examples are invalid.Think that agrimonine is mainly to suppress by removing vagus nerve, speeds the rhythm of the heart and works; To the reparation of myocardial damage, improve myocardial metabolism effect not clearly.5. other: with hairyvein agrimony 0.5～1 liang of decoction, 1 dose of every day, serve on 5～7 days, the leptospirosis of the sad cold type of convection current has certain prevention effect.
Artemisia anomala: hardship, temperature.Enter the heart, the spleen channel.Function cures mainly: blood stimulates the menstrual flow, healing up sore and subduing swelling.Control through closing abdominal mass, chest and abdomen swelling and pain, postpartum blood stasis, traumatic injury, metal-inflicted wound is hemorrhage, Yong Du inflammation is swollen.
The arched end: hardship, cold, enter stomach, large intestine two warps.Function cures mainly: heat, removing toxic substances, detumescence, pain relieving.Control abscess of throat, toothache, red eye, swell pain, bacillary dysentery, enteritis, stomachache, hepatitis, urinary tract infections, malignant boil is swollen.1. antibacterial action: saponin and bitter principle (being Hemsleyadin hybrid junctions product) have antibacterial action in various degree to bacterium flexneri, hemolytic streptococcus, staphylococcus aureus, Salmonella choleraesuls etc. in vitro, valid density is 0.1 mcg/ml, and effect and chloramphenicol are close or stronger.Typhoid bacillus, Escherichia coli are also had to bacteriostasis when 10～100 mcg/ml concentration.2. other effects: 4 mgs/kg of anesthetized cat intravenous injection bitter principles, can suppress heart, as increase to 12 mgs/kg, can cause rhythm of the heart serious hindrance, cause death.Hemsleyadin (first) is given 40 mgs/kg of anesthetized dog intravenous injections, blood pressure, breathing, heart rate are had no significant effect. and to 10 mgs/kg of intravenous rabbit injections, obviously suppress heartbeat amplitude, if dosage is 20～40 mgs/kg, occur block, last heartbeat stops.Therefore need to be cautious use of cardiac.In the test of isolated rabbit and small intestine of guinea pig, Hemsleyadin (first) there is no the spasmolysis of the brilliant sample of atropic to smooth muscle, to isolated uterine also without obvious effect.To rabbit lumbar injection, 40 mgs/kg of heatings that typhoid and paratyphoid vaccine is caused have slight antipyretic effect, but normal body temperature and non-bacterial (turpentine oil) heating are had no significant effect, the saponin aqueous solution (5 mg/ml) can suppress isolated frog heart, but is light compared with bitter principle (1 mcg/ml can suppress).The haemolytic index of saponin is 1:600.The total saponin of hymsleya amabilis can increase mouse coronary flow (400 mgs/kg of gavages, the 3rd day with amount lumbar injection, by rubidium 86 trace methods mensuration), and resist the coronary artery contraction (rubidium 86 methods and electrocardiography) that pituitrin causes, and can reduce MCO.The effect of its coronary artery dilating is without tachyphylaxis. to Experimental Atherosclerotic Rabbits, without significantly hypocholesterolemic effect; Artery plaque or liver fat lesion, medication group is seemingly light compared with control group.70 mgs/kg of intravenous injections have hypotensive effect to anesthetized dog, and have tachyphylaxis, and duodenal administration does not cause step-down.
Dandelion: there is the effect of resisting pathogenic microbes, Dandelion Injectable Solution has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus in vitro, and Diplococcus pneumopniae, meningococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, proteus, shigella dysenteriae, typhoid bacillus etc. and micrococcus catarrhalis are also had to certain bactericidal action.Dandelion extract (1:400) can suppress tulase in vitro.Dandelion water decoction (1:80) can delay ECHO11 virocyte pathology.Taraxol extract 31mg/kg can kill Leptospira.Water logging agent has inhibitory action to various skin fungi.Decoction, to Oral Administration in Rats, absorbs well, in urine, can keep certain antibacterial action.Also have protect the liver, the effect of cholagogic, by dandelion decoction gavage or with Dandelion Injectable Solution injection, the glutamic-pyruvic transaminase that carbon tetrachloride is caused raises obvious inhibitory action; Can significantly alleviate the Histological change that carbon tetrachloride liver damage causes.Have report to point out, dandelion has choleretic effect in animals.Dandelion liquid gavage can make gallbladder contraction, and oddi's sphincter is lax, is conducive to bile and enters in intestines.Effective to chronic gallbladder spasmolytic and calculosis clinically.Also there is immunologic function, dandelion decoction can significantly improve PBLC blast transformation rate in vitro, Taraxacum Polysaccharides can significantly strengthen ehrlich carcinoma and MM46 tumor-cell antigen induced mice foot pad delayed allergy intensity, and have an administration time more effective feature more backward, i.e. administration on the 11st～20th after antigenic stimulus or 2～20 the next day administration have obvious effect.Taraxacum Polysaccharides lumbar injection can significantly strengthen the CDCC of mouse antibodies dependence macrophage.
Evergreen: bitter, sweet, cold.Function cures mainly: thermal detoxification, cardiac stimulant diuresis.Be used for preventing and treating diphtheria, the myocarditis that diphtheria causes, abscess of throat, lyssodexis, bacillary dysentery, Cardiac Failure From Rheumatic Heart Disease; Traumatic injury is controlled in external application, venomous snake bite, burn and scald, mastitis, carbuncle furuncle poison.
The Radix Astragali: take qi-restoratives as main, energy invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore cave in, purulence becomes not burst or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be used for preventing the generation of some infectious disease.< < book on Chinese herbal medicine meets former > > to carry: " all void of Radix Astragali energy tonifying five zang organs, controls arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly sends out, and has sweat to stop." be the good medicine of promoting resistance and defence disease.
Fern fiber crops: sweet, flat.Function cures mainly: qi and blood, strengthening the spleen and stomach, promotes the production of body fluid to quench thirst, dampness removing.Be used for anaemia after being ill, malnutrition, insufficiency of the spleen diarrhoea, arthralgia due to wind-dampness.
Dried orange peel: regulating the flow of Qi and the middle Jiao, eliminating dampness and eliminating phlegm, sharp water defaecation.Cure mainly incoordination between the spleen and the stomach, abdominal distention, do not feel like eating, vomiting hiccup; Phlegm-damp obstructing lung, coughing with a lot of sputum, chest diaphragm is full vexed, vertigo; Oedema, difficult urination, constipation; Acute mastitis sore tinea, middle fish crab poison, wine poison.For diseases such as fullness and oppression of chest and abdomen.The pungent loose logical temperature of orange peel, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of qi wide in, for lung qi gather around stagnant, chest diaphragm ruffian full and the disease such as the taste stagnation of the circulation of vital energy, abdominal fullness and distention.Temperature eliminating dampness and can invigorating the spleen promoting the circulation of qi, therefore be usually used in the diseases such as damp retention in middle-jiao, gastral cavity abdominal distension is vexed, loose stool tongue is greasy, can compatibility rhizoma atractylodis, the bark of official magnolia is with using.Be good at again eliminating dampness and eliminating phlegmly, for controlling wet phlegm, stop up the conventional key medicines of lung, the many coughs of phlegm, every with the tuber of pinellia, Poria cocos with use.For insufficiency of the spleen diet reduce, indigestion, and the disease such as n and V, eliminating dampness and can spleen benefiting and stimulating the appetite, is applicable to the diseases such as weakness of the spleen and the stomach, diet minimizing, indigestion, stool diarrhea, the fit applications such as normal and ginseng, the bighead atractylodes rhizome, Poria cocos.Can invigorating the spleen because of it, can regulate the flow of vital energy again, therefore often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up the swollen effect of doing of holding back.In addition, orange peel again can with in, can control stomach Qi rising, n and V.
Dalbergia wood: pungent, temperature.Return liver, the spleen channel.Function with cure mainly the promoting flow of qi and blood circulation, pain relieving, hemostasis.For epigastric pain, liver-depressed hypochondrium pain, obstruction of qi in the chest shouting pain, injury from falling down, traumatism and bleeding.. < < herbal classic is met former > >: look red to fall that it smells really good, and enter blood system and decline, thus for oral administration can promoting circulation of blood broken stagnant, the outer painting analgesic therapy of can stopping blooding.Deficiently again tell redly, look stasis of blood taste not fresh person should add with it, and its merit and marmor serpentinatum are loose not different.
Tinosporae: hardship, cold.Return lung, large intestine channel.Function cures mainly: thermal detoxification, relieve sore throat, pain relieving.For abscess of throat, ulcer serious case of furuncle, has loose bowels, dysentery, gastral cavity abdomen heat pain.
Herba Cyathulae Prostratae: bitter, sweet, flat.Function cures mainly: thermal detoxification.For bacillary dysentery.The long-pending eliminating phlegm that disappears, swelling and pain relieving.For infantile malnutrition, hepatosplenomegaly, pulmonary tuberculosis, snake bite, traumatic injury, sore swollen toxin.
Maggot: salty, cold.Enter spleen, stomach warp.Function cures mainly: heat-clearing, disappears stagnant.Control infantile malnutrition due to digestive disturbances or intestinalparasites abdominal distension, infantile malnutrition due to digestive disturbances or intestinalparasites sore.
Chinese medicine additive of the present invention also comprises following raw medicinal material:
Umbellate pore furgus: have the diuresis swollen effect of harnessing the river.Containing grifola polysaccharide (glucan), test anticancer.Umbellate pore furgus taste is sweet, light, flat, returns kidney, urinary bladder channel.Clearing damp and promoting diuresis.Control difficult urination, oedema, have loose bowels, stranguria with turbid discharge, under band.There is the effect that diuresis is antitumor and protect the liver.
Amomum cardamomum: pungent, temperature.Enter lung, the spleen channel.Function cures mainly: promoting the circulation of qi, warm stomach, helps digestion, wide in.Control the stagnation of the circulation of vital energy, eat stagnant, uncomfortable in chest, abdominal distension, gas, dysphagic, tell contrary, gastric disorder causing nausea, malaria.1. < < Kaibao Bencao > >: " main long-pending cold air, antiemetic is contrary, gastric disorder causing nausea, Gu Xiaqi disappears." 2. < < Bencao Tujing > >: " main stomach is cold." 3. < < medicine origin > >: " < < cures mainly the secret > > cloud of wanting, this medicine of lung gold, loose stagnant gas in the heart, the cold stomachache of sense, warm taste, cute conjunctivitis breaks out, the red person of white of the eye." 4. Yang Shiying: " controls insufficiency of the spleen malaria, vomiting, and fever and chills, can grind popular three warmers in energy dissipating." 5. Wang Haogu: " tonifying lung gas, beneficial taste, reason vigour, receives degassed." 6. < < detailed outline > >: " controls dysphagic, except malaria, and fever and chills, relieving alcoholism." 7. < < Essentials of Materia Medica > >: ", except cold eliminating dampness, helping digestion is wide swollen."
The bighead atractylodes rhizome: be the dry rhizome of the feverfew bighead atractylodes rhizome.Return spleen, stomach warp, bitter, sweet and warm in nature.Function strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.< < medicine origin > > records the bighead atractylodes rhizome " dehumidifying benefit is dry, and middle beneficial gas, in temperature, goes to wet in taste, and except stomach energy, strong taste, enter diet, quench the thirst, antiabortive "; < < Sheng Nong's herbal classic > > records the bighead atractylodes rhizome " the sweet temperature of smell, nontoxic, control wind-cold-dampness arthralgia, dead flesh, convulsion subcutaneous ulcer, hidroschesis, heat extraction, help digestion "; < < drug property cerse > > records the bighead atractylodes rhizome, and " taste is sweet, and temperature is nontoxic.Can rise and can fall, sun also.It is with having four: dredging water passages, has the merit of dehumidifying; Strong taste, have the effect of feed, and the assistant root of large-flowered skullcap has antiabortive energy, and monarch's dried immature fruit of citron orange has the wonderful of the ruffian of disappearing ".
Poria cocos: sweet, light, flat.The thoughts of returning home, lung, spleen, kidney channel.Function clearing damp and promoting diuresis, the peaceful heart of invigorating the spleen.For oedema oliguria, phlegm and retained fluid is dizzy throbs with fear, and insufficiency of the spleen food is few, and have loose bowels in loose stool, confused and worried, palpitation with fear insomnia.Eliminating dampness and diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Control difficult urination, oedema turgor, phlegm and retained fluid is coughed contrary, and the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful.< < herbal classic > > carries it: " the contrary gas of the main chest side of body, sorrow is angerd frightened heresy and is probably throbbed with fear, knot pain under the heart, fever and chills dysphoria, coughs contraryly, and mouthful burnt tongue is dry, diuresis." < < do not record > >: " and only quench one's thirst, like to sleep, large abdomen, drenches drop, phlegm water in diaphragm, and oedema is drenched knot.Open chest internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, beneficial strength, during guarantor god keeps." < < property of medicine opinion > >: " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease phlegm is stopped up.Control pediatric epilepsy scared, trusted subordinate's turgor, married woman's heat is drenched.”
Chinese yam: taste is sweet, property is flat, enters lung, spleen, kidney channel; Not dry oiliness, have and strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, strengthening the bones and muscles, grow the effect that will is calmed the nerves, promoted longevity; Cure mainly that weakness of the spleen and the stomach, lassitude, poor appetite, chronic diarrhea and dysentery, Lung Qi deficiency are dry, asthma due to excessive phlegm cough, kidney qi loss, soreness and weakness of waist and knees, lower limb impotence are weak, the red illness such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, the lower gonorrhoea of band, skin.< < Compendium of Materia Medica > > summarizes five large functions " kidney-nourishing gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Chinese yam is cooked congee or simmers after ripe and take with rock sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treat weakness of the spleen and the stomach, have loose bowels, body is tired, food less, abnormal sweating.Benefit lung nourshing kidney: this product is cold not dry, taste Gan Zhirun, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.
Embodiment 1 feed 1
The embodiment of the present invention provides a kind of feed that is used for the treatment of swine dysentery, and feed is comprised of the raw material of following parts by weight: flour 50 weight portions, millet 60 weight portions, egg yolk 30 weight portions, lotus root starch 30 weight portions, lotus seeds 10 weight portions, vitamin C 5 weight portions, probiotics 3 weight portions and Chinese medicine additive 5 weight portions.
Wherein, probiotics is bacillus and lactic acid bacteria, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the dried immature fruit of citron orange 23 weight portions, chickweed 15 weight portions, the Chinese bulbul 14 weight portions, rotten inferior 17 weight portions, shepherd's purse 21 weight portions, blue pig ear 15 weight portions, lychee exocarp 17 weight portions, forrest bugle herb 14 weight portions, hairyvein agrimony 15 weight portions, Artemisia anomala 15 weight portions, weight portion of the arched ends 15, dandelion 21 weight portions, evergreen 17 weight portions, the Radix Astragali 28 weight portions, fern fiber crops 16 weight portions, dried orange peel 20 weight portions, dalbergia wood 19 weight portions, tinosporae 13 weight portions, Herba Cyathulae Prostratae 13 weight portions and maggot 17 weight portions.
The preparation method of the Chinese medicine additive of the embodiment of the present invention comprises the following steps: according to ratio of weight and number, take all raw medicinal materials, first raw medicinal material is put into the ethanol that 10 times of amount determining alcohols are 85%, twice of heating and refluxing extraction, each 45 minutes, extract active ingredient, by standing the merging of extracted twice liquid, the dregs of a decoction are standby; The dregs of a decoction are added to 10 times of water gagings, and heating and refluxing extraction 3 times, each 1 hour, merges No. 3 extracts; Decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.06; The large pore resin absorption column wash-out twice that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol eluate, removes solvent, obtains raw material liquid; To the starch that adds raw material liquid weight 5% in raw material liquid, after stirring, dry, grind into powder.
The preparation method of the feed of the embodiment of the present invention comprises the following steps:
(1) broken step: take by weight percentage millet, egg yolk and lotus seeds input pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into flour, lotus root starch, vitamin C, probiotics and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again.
Embodiment 2 feeds 2
The embodiment of the present invention provides a kind of feed that is used for the treatment of educational background, and feed is comprised of the raw material of following parts by weight: flour 65 weight portions, millet 54 weight portions, egg yolk 15 weight portions, lotus root starch 27 weight portions, lotus seeds 13 weight portions, vitamin C 6 weight portions, probiotics 7 weight portions and Chinese medicine additive 8 weight portions.
Wherein, probiotics is lactic acid bacteria, Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: the dried immature fruit of citron orange 23 weight portions, chickweed 16 weight portions, the Chinese bulbul 14 weight portions, rotten inferior 18 weight portions, shepherd's purse 19 weight portions, blue pig ear 15 weight portions, lychee exocarp 14 weight portions, forrest bugle herb 13 weight portions, hairyvein agrimony 15 weight portions, Artemisia anomala 16 weight portions, weight portion of the arched ends 13, dandelion 19 weight portions, evergreen 14 weight portions, the Radix Astragali 24 weight portions, fern fiber crops 15 weight portions, dried orange peel 21 weight portions, dalbergia wood 19 weight portions, tinosporae 15 weight portions, Herba Cyathulae Prostratae 14 weight portions, maggot 15 weight portions, umbellate pore furgus 13 weight portions, Amomum cardamomum 15 weight portions, the bighead atractylodes rhizome 16 weight portions, Poria cocos 18 weight portions and Chinese yam 16 weight portions.
The preparation method of the Chinese medicine additive of the embodiment of the present invention comprises the following steps: according to ratio of weight and number, take all raw medicinal materials, first raw medicinal material is put into the ethanol that 10 times of amount determining alcohols are 85%, twice of heating and refluxing extraction, each 45 minutes, extract active ingredient, by standing the merging of extracted twice liquid, the dregs of a decoction are standby; The dregs of a decoction are added to 10 times of water gagings, and heating and refluxing extraction 3 times, each 1 hour, merges No. 3 extracts; Decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.06; The large pore resin absorption column wash-out twice that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol eluate, removes solvent, obtains raw material liquid; To the starch that adds raw material liquid weight 5% in raw material liquid, after stirring, dry, grind into powder.
The preparation method of the feed of the embodiment of the present invention is as follows:
(1) broken step: take by weight percentage millet, egg yolk and lotus seeds input pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into flour, lotus root starch, vitamin C, probiotics and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 25s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again.
Toxicity test
1, cumulative toxicity test report
Select 20 healthy mices, female, male each 10, take the Chinese medicine additive of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.Take the Chinese medicine additive 2 of embodiment 2 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.
2, acute toxicity test
40 of application NIH mouse, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mouse is divided into two groups at random, and 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; Chinese medicine additive prepared by embodiments of the invention 1 is dissolved in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mouse.Experimental result shows: with control group comparison, after administration, mouse has no notable difference, experiment Continuous Observation 14 days, and mouse overall health of patients, diet, drinking-water, body weight gain are all normal.The Chinese medicine additive LD50>32.9 crude drug/kg of the mouse oral administration gavage embodiment of the present invention 1, every day, maximum dosage-feeding was 65.8g crude drug/kg/ day.The clinical application amount of the embodiment of the present invention 1 Chinese medicine additive is 3g crude drug/day/head, and piglet body weight is in 6kg, and average dosage is 0.5g crude drug/kg/ day.By batheroom scale: the dosis tolerata of the Chinese medicine additive of mouse (average weight is take 20g) the oral administration gavage embodiment of the present invention 1 is 131 times of quantity.Therefore the acute toxicity of the Chinese medicine additive of the embodiment of the present invention 1 is low, clinical drug safety.Take the Chinese medicine additive of embodiment 2 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.
Clinical testing
(1) animal used as test
Certain pig farm finds that in October, 2011 phenomenon of pig death appears in piglet group, and other pigs row is red just rare, is gel-shaped, has stench taste, mucus is many, has the fragmentary intestinal mucosa coming off, and spirit is not good enough, poor appetite, frequently lie prone sleeping, the back of a bow that stands up, hangs abdomen, and hyperthermia is more than 39 ℃.Cut open the dead pig of inspection, find that hemorrhagic colitis appears in dead Radix Polygalae Crotalarioidis, ileocecal opening has obvious boundary; the obvious phleboedesis of pathology is swollen, and mucous membrane hyperemia, hemorrhage or downright bad coming off, be full of mucus in enteric cavity; large mesenterium enlargement of lymph nodes, and by hair slightly disorderly, pig body turns white dead pig.Take ill pig fresh excreta or dead piglet colorectal mucosa smear, with the dyeing of Ji's Pehanorm, microscopy is found 3-5 bar conveyor screw in the visual field.Get pathological material of disease simultaneously and add physiological saline and make to press and drip a sample, under the dark field of 600 power microscopes, observe, find each visual field have 2-3 be slowly snakelike sample motion compared with king bolt body.Through EUSA, detect as the swine dysentery positive.Be diagnosed as in swinery 400 piglets nearly and suffer from swine dysentery, select 180 body weight the ill piglet of 12kg left and right as experiment pig.
(2) test method
180 ill piglets are divided into three experimental group at random, and 60 every group, every group of average weight is 12kg.Three groups are used respectively the feed 1(embodiment group 1 of the embodiment of the present invention 1), the feed 2(embodiment group 2 of embodiment 2) and conventional medicament (control group) treat.Control group is used conventional feed to feed, and uses conventional medicament to treat, and conventional medicament is selected LIJUNJING (MAQO, 3-methyl-acetyl group-quinoline is disliked woods-Isosorbide-5-Nitrae-dioxide) 5mg/kg, gavages every day 2 times.Test period is 7 days.
(3) criterion of therapeutical effect
Recovery from illness: mental status, appetite, stool colour and shape etc. are all recovered normally, to detect by ight soil, do not find conveyor screw in the visual field, is judged to be recovery from illness;
Effective: mental status, appetite, stool colour and shape etc. are basic recovers normal, by ight soil, detects, and does not find conveyor screw in the visual field, is judged to be effective;
Effective: mental status, appetite, stool colour and shape etc. are basic recovers normal, by ight soil, detects,, find to be slowly individually in the visual field in snakelike sample motion compared with king bolt body, be judged to be effective;
Invalid: after medication, the state of an illness even increases the weight of or death without taking a turn for the better, and it is invalid to be judged to.
Wherein, recovery from illness and effective number are counted efficient.
(4) treatment results
Result for the treatment of is as shown in table 1, and from result for the treatment of, adopting feed of the present invention is more than 90% to the treated effect of swine dysentery, higher than control group.Before and after experiment, the piglet changes of weight table of comparisons is as shown in table 2.
The table 1 result for the treatment of table of comparisons
From the data of table 1, can find out: compared with control group, use the feed treatment swine dysentery of the embodiment of the present invention 1 and embodiment 2, have advantages of evident in efficacy, cure rate is high; In long-term observation subsequently, find, the piglet that embodiment group 1 and embodiment group 2 are cured the again incidence of disease is starkly lower than the pig of control group.
The piglet changes of weight table of comparisons before and after table 2 experiment
From the data of table 2, can find out, compared with control group, use the feed treatment swine dysentery of the embodiment of the present invention 1 and embodiment 2, not only there is the effect for the treatment of swine dysentery, but also can guarantee the production performance of piglet.
Concrete case
Case 1
Lee in May, 2012 find 18 3 the monthly age piglet all appearance in various degree row is red just rare, be gel-shaped, have stench taste, mucus is many, off color, poor appetite, frequently lie prone sleeping, the back of a bow that stands up, hangs abdomen, and hyperthermia is more than 39 ℃, fresh excreta, with the dyeing of Ji's Pehanorm, microscopy is found 3-5 bar conveyor screw in the visual field.Be diagnosed as swine dysentery, use the feed of the embodiment of the present invention 1 to feed according to the mode of feeding normally, use continuously 5 days, 18 piglets all recover normal.
Case 2
In July, 2012 pig farm find 2 the monthly age piglet there is the phenomenon of die by visitation of God, other piglets occur that row is red just rare, spirit is not good enough, poor appetite, more than hyperthermia to 39 ℃, gets fresh excreta, with the dyeing of Ji's Pehanorm, microscopy is found 3-5 bar conveyor screw in the visual field.Cut open the dead pig of inspection, find that hemorrhagic colitis appears in dead Radix Polygalae Crotalarioidis, ileocecal opening has obvious boundary; the obvious phleboedesis of pathology is swollen, and mucous membrane hyperemia, hemorrhage or downright bad coming off, be full of mucus in enteric cavity; large mesenterium enlargement of lymph nodes, and by hair slightly disorderly, pig body turns white dead pig.Be diagnosed as after swine dysentery, use the feed of the embodiment of the present invention 2 to treat, according to the mode of feeding normally, feed, use continuously 4 days, 92% piglet all recovers normally, continues to use two days, finds that residue piglet also all recovers normally.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. the feed that is used for the treatment of pig bloody flux, is characterized in that, described feed comprises following raw material: flour, millet, egg yolk, lotus root starch, lotus seeds, vitamin C, probiotics and Chinese medicine additive.
2. the feed that is used for the treatment of pig bloody flux according to claim 1, it is characterized in that, described feed is comprised of the raw material of following parts by weight: flour 50-70 weight portion, millet 40-60 weight portion, egg yolk 10-30 weight portion, lotus root starch 20-30 weight portion, lotus seeds 10-20 weight portion, vitamin C 5-8 weight portion, probiotics 3-8 weight portion and Chinese medicine additive 5-11 weight portion.
3. the feed that is used for the treatment of pig bloody flux according to claim 1 and 2, it is characterized in that, described feed is comprised of the raw material of following parts by weight: flour 65 weight portions, millet 54 weight portions, egg yolk 15 weight portions, lotus root starch 27 weight portions, lotus seeds 13 weight portions, vitamin C 6 weight portions, probiotics 7 weight portions and Chinese medicine additive 8 weight portions.
4. according to the feed that is used for the treatment of pig bloody flux described in claim 1-3 any one, it is characterized in that, described Chinese medicine additive comprises following raw medicinal material: the dried immature fruit of citron orange, chickweed, the Chinese bulbul, rotten inferior, shepherd's purse, blue pig ear, lychee exocarp, forrest bugle herb, hairyvein agrimony, Artemisia anomala, the arched end, dandelion, evergreen, the Radix Astragali, fern fiber crops, dried orange peel, dalbergia wood, tinosporae, Herba Cyathulae Prostratae and maggot.
5. according to the feed that is used for the treatment of pig bloody flux described in claim 1-4 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 15-30 weight portion, chickweed 10-20 weight portion, Chinese bulbul 10-20 weight portion, rotten inferior 10-20 weight portion, shepherd's purse 15-25 weight portion, blue pig ear 10-20 weight portion, lychee exocarp 10-20 weight portion, forrest bugle herb 10-15 weight portion, hairyvein agrimony 10-20 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 10-20 weight portion, Radix Astragali 20-30 weight portion, fern fiber crops 10-20 weight portion, dried orange peel 15-25 weight portion, dalbergia wood 15-25 weight portion, tinosporae 10-20 weight portion, Herba Cyathulae Prostratae 10-20 weight portion and maggot 10-20 weight portion.
6. according to the feed that is used for the treatment of pig bloody flux described in claim 1-5 any one, it is characterized in that, described feed is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 18-27 weight portion, chickweed 13-17 weight portion, Chinese bulbul 12-17 weight portion, rotten inferior 15-20 weight portion, shepherd's purse 18-23 weight portion, blue pig ear 11-18 weight portion, lychee exocarp 13-20 weight portion, forrest bugle herb 13-15 weight portion, hairyvein agrimony 12-18 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 14-20 weight portion, Radix Astragali 25-30 weight portion, fern fiber crops 12-20 weight portion, dried orange peel 17-23 weight portion, dalbergia wood 15-23 weight portion, tinosporae 10-15 weight portion, Herba Cyathulae Prostratae 10-16 weight portion and maggot 14-20 weight portion.
7. according to the feed that is used for the treatment of pig bloody flux described in claim 1-6 any one, it is characterized in that, described Chinese medicine additive also comprises: umbellate pore furgus, Amomum cardamomum, the bighead atractylodes rhizome, Poria cocos and Chinese yam.
8. according to the feed that is used for the treatment of pig bloody flux described in claim 1-7 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following parts by weight: dried immature fruit of citron orange 15-30 weight portion, chickweed 10-20 weight portion, Chinese bulbul 10-20 weight portion, rotten inferior 10-20 weight portion, shepherd's purse 15-25 weight portion, blue pig ear 10-20 weight portion, lychee exocarp 10-20 weight portion, forrest bugle herb 10-15 weight portion, hairyvein agrimony 10-20 weight portion, Artemisia anomala 10-20 weight portion, arched end 10-20 weight portion, dandelion 15-25 weight portion, evergreen 10-20 weight portion, Radix Astragali 20-30 weight portion, fern fiber crops 10-20 weight portion, dried orange peel 15-25 weight portion, dalbergia wood 15-25 weight portion, tinosporae 10-20 weight portion, Herba Cyathulae Prostratae 10-20 weight portion, maggot 10-20 weight portion, umbellate pore furgus 10-15 weight portion, Amomum cardamomum 10-16 weight portion, bighead atractylodes rhizome 15-20 weight portion, Poria cocos 15-20 weight portion and Chinese yam 15-20 weight portion.
9. according to the feed that is used for the treatment of pig bloody flux described in claim 1-8 any one, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
According to ratio of weight and number, take all raw medicinal materials, first raw medicinal material is put into the ethanol that 10 times of amount determining alcohols are 85%, heating and refluxing extraction twice, each 45 minutes, extract active ingredient, by standing the merging of extracted twice liquid, the dregs of a decoction are standby; The dregs of a decoction are added to 10 times of water gagings, and heating and refluxing extraction 3 times, each 1 hour, merges No. 3 extracts; Decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after suction filtration, when the relative density of filtrate is about 20 ℃ 1.06; The large pore resin absorption column wash-out twice that above-mentioned filtrate is 10L through volume, first uses deionized water or the distilled water wash-out of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol eluate, removes solvent, obtains raw material liquid; To the starch that adds raw material liquid weight 5% in raw material liquid, after stirring, dry, grind into powder.
10. a preparation method for the feed that is used for the treatment of swine dysentery as described in claim 1-9 any one, is characterized in that, described preparation method comprises the following steps:
(1) broken step: take by weight percentage millet, egg yolk and lotus seeds input pulverizer and carry out Crushing of Ultrafine, cross 2.0mm sieve after pulverizing;
(2) batching step: sneak into flour, lotus root starch, vitamin C, probiotics and Chinese medicine additive according to ratio of weight and number, drop into mixer, mix, incorporation time is 20-30s;
(3) granulation step: drop into granulator and granulate, pelleting temperature is 70 ℃, and its gelatinization degree is reached more than 90%;
(4) classification step: after granulation, sieve classification is crossed in fragmentation again.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104351575A (en) * | 2014-12-03 | 2015-02-18 | 山东新希望六和集团有限公司 | Compound feed for treating swine dysentery and preparation method of compound feed for treating swine dysentery |
| CN104799003A (en) * | 2015-05-18 | 2015-07-29 | 山东新希望六和集团有限公司 | Compound feed for 10-30-day-old piglets and preparing method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN102835609A (en) * | 2012-09-27 | 2012-12-26 | 山东新希望六和集团有限公司 | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition |
| CN103417703A (en) * | 2013-09-09 | 2013-12-04 | 周冠旻 | Medicine for treating dysentery of pigs |
| CN103417787A (en) * | 2013-09-05 | 2013-12-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine drug granules used for prevention and treatment of pig dysentery and preparation method of traditional Chinese medicine drug granules |
-
2013
- 2013-12-25 CN CN201310725390.4A patent/CN103719616B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526302A (en) * | 2011-12-31 | 2012-07-04 | 郑州后羿制药有限公司 | Chinese medicinal micro-ecological preparation for inhibiting piglet bacterial dysentery and preparation method thereof |
| CN102835609A (en) * | 2012-09-27 | 2012-12-26 | 山东新希望六和集团有限公司 | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition |
| CN103417787A (en) * | 2013-09-05 | 2013-12-04 | 天津生机集团股份有限公司 | Traditional Chinese medicine drug granules used for prevention and treatment of pig dysentery and preparation method of traditional Chinese medicine drug granules |
| CN103417703A (en) * | 2013-09-09 | 2013-12-04 | 周冠旻 | Medicine for treating dysentery of pigs |
Non-Patent Citations (1)
| Title |
|---|
| 霍全胜: "自拟中药方剂防治猪痢疾", 《中兽医学杂志》, no. 2, 31 December 2007 (2007-12-31), pages 17 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104351575A (en) * | 2014-12-03 | 2015-02-18 | 山东新希望六和集团有限公司 | Compound feed for treating swine dysentery and preparation method of compound feed for treating swine dysentery |
| CN104799003A (en) * | 2015-05-18 | 2015-07-29 | 山东新希望六和集团有限公司 | Compound feed for 10-30-day-old piglets and preparing method thereof |
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Effective date of registration: 20210407 Address after: 751600 Jiabao Industrial Park, Qingtongxia City, Wuzhong City, the Ningxia Hui Autonomous Region Patentee after: Ningxia new hope Ruminant Nutrition Food Co., Ltd Address before: 266061 Qingdao Industrial Park, Ji Hong Tan Street, Chengyang District, Qingdao, Shandong. Patentee before: SHANDONG NEW HOPE LIUHE GROUP Co.,Ltd. |
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