Summary of the invention
For overcoming the deficiency of prior art; The present invention provides a kind of skin-protection type Chinese herbal medicine natural bacteriostatic hand sanitizer, adds the natural materials with bacteriostasis and skin care, in decontamination, has good antibacterial and skin care effect again; The natural component performance is gentle, the non-stimulated and irritated effect to skin.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
10~30 parts in surfactant, 0.5~12 part of Chinese herbal medicine extract, 2.5~8 parts of adjuvant, 40~85 parts of purified water;
Described Chinese herbal medicine extract by in following four kinds of raw materials any three kinds formulated by weight:
0.1~8 part of the Oleum Cinnamomi of 85% (weight);
0.1~3 part of the Oleum Caryophylli of 85% (weight);
0.1~5 part in olive oil;
0.1~2.5 part of Oleum Vitis viniferae.
Described surfactant is formulated by weight by following raw materials according:
5~20 parts of the α-Xi Jihuangsuanyans of 35% (weight);
0~10 part of the polyoxyethylenated alcohol sodium sulfate of 70% (weight);
0~10 part of the amine oxide of 30% (weight);
Fatty alcohol-polyoxyethylene ether-9 0.5~8 part;
0.1~3 part of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant comprises the following raw material of preparation by weight:
0.1~2 part of disodiumedetate;
0.1~3 part in carbamide;
0.1~2 part of citric acid;
0.5~7 part in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing the said herbal medicine skin care type natural bacteriostatic hand sanitizer, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to the said weight portion of claim 1, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required surfactant successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Chinese herbal medicine extract and stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
The present invention compares the beneficial effect that has with prior art:
1, handwashing liquid raw material sources of the present invention are wide, and cost is low, and the medicinal herb components consumption is few, and skin protection and fungistatic effect are remarkable, steady quality.
Oleum Cinnamomi is extracted and is got by Cortex cinnamomi japonici (Ramulus Cinnamomi), Laurus nobilis, Ramulus Cinnamomi etc., and wherein cinnamic aldehyde content is up to 80%~95%, and cinnamic aldehyde has been the effective ingredient of bacteriostasis.Cortex Cinnamomi is fragrant, sweet in the mouth is hot, hot in nature, is the dietotherapeutic plant that China's Ministry of Public Health is announced.Emotion can be invigorated, improved to Oleum Cinnamomi, the muscle spasm and improve joint rheumatalgia symptom of releiving simultaneously.Oleum Cinnamomi has the broad-spectrum biocidal property, antibacterial, mycete and yeast is all had stronger inhibition effect, like escherichia coli, Salmonella, dysentery bacterium, Bacillus typhi, staphylococcus aureus, Candida albicans, bacillus subtilis; Bacillus thuringiensis, yeast, aspergillus oryzae; Penicillium sp; Trichoderma spp., Mucor, rhizopus etc.Oleum Cinnamomi has very strong inhibitory action to dermatophytes, and the restraint of mycete obviously is superior to ethyl hydroxybenzoate, can significantly suppress the mycelial growth and the Sporulation of aspergillus niger.
Oleum Caryophylli is that the alabastrum by Flos Caryophylli gets through steam distillation, and eugenol wherein is the strongest active component of anti-staphylococcus aureus.In addition, Oleum Caryophylli all has significant bacteriostasis to Klebsiella oxytoca, Salmonella enteritidis, shigella dysenteriae, escherichia coli, staphylococcus epidermidis, and stronger than 1% berberine.Experimental result shows in the body, and Flos Caryophylli volatile oil lumbar injection or gastric infusion all can reduce the mortality rate of the chmice acute infection that is caused by escherichia coli and staphylococcus aureus.
Olive oil is the natural fruit oil of Fructus Canarii albi fruit, as thousands of years of the history of skin care item, the good reputation of " liquid golden " is arranged.Olive oil contains the nutritional labeling of multiple needed by human body, and its fatty acid and multiple natural grease soluble vitamin are very favourable to nourishing skin.Vitamin A in the olive oil can moisten exsiccant skin, prevents that skin is wrinkling; Skin elasticity can protected and strengthen to vitamin D, and prophylaxis of wrinkles takes place; Vitamin E can impel blood circulation unimpeded, suppresses skin aging and flexibility decrease; Vitamin K can make skin flexible.Though be " oil ", with after clearly oiliness, be easily absorbed by the body.
Oleum Vitis viniferae contains various mineral elements and multivitamin, can diseases prevention, cure the disease and defying age.Abroad, Oleum Vitis viniferae is as baby, old man, pilot's high-grade nutrient oil.The mineral element potassium, sodium, calcium, ferrum, zinc, copper, the manganese that contain needed by human in the Oleum Vitis viniferae; Contain multivitamin, promote growth promoter and improve health conditions; Contain the linoleic acid more than 76%, can adjust low density lipoprotein, LDL and high density lipoprotein, the effect of nutritious brain cell, adjusting vegetative nerve, anti-tampon and prevention coronary heart disease.
2, use described Chinese herbal medicine oil and surfactant optimum organization; Prepare functional handwashing liquid; Be that the present invention had both had good hand skin cleaning action, have the bacteriostatic synergistic function again, again hand skin is played nutrition, moist, moisture-keeping function simultaneously.Olive oil and Oleum Vitis viniferae contain multiple natural grease soluble vitamin, have moisten to support skin, prevent that skin is wrinkling, protection and strengthen effect such as skin elasticity, be specially adapted to hand skin dry easily with the characteristics that produce wrinkle, make skin restore nature elasticity.
3, handwashing liquid good antimicrobial effect of the present invention.Described Chinese herbal medicine oil; Like cinnamic aldehyde in the Oleum Cinnamomi and the eugenol in the Oleum Caryophylli is the very strong effective ingredient of bacteriostasis; Result of the test of the present invention shows that adding a small amount of Oleum Cinnamomi and Oleum Caryophylli promptly has very strong bacteriostasis to staphylococcus aureus, escherichia coli, bacillus subtilis, Bacillus typhi.The minimal inhibitory concentration of handwashing liquid of the present invention and MBC, like following table:
4, the present invention is used for the liquid handwashing liquid with Chinese herbal medicine oil, and outward appearance is even emulsion, original flavor fragrance, and it is good to place three months stabilities.The present invention tests in the refrigerator that is shown in-10 ℃~-3 ℃ and places 24h, takes out and does not have layering and flocculation when returning to room temperature; Place 24h in the couveuse of (40 scholar 1) ℃, take out and observe not stratifiedly, and do not change abnormal smells from the patient.
5, handwashing liquid of the present invention skin irritation test through tame rabbit back spinal column both sides, perusal 48h, the result smears the anhydrous swollen and erythema in position, explains that the present invention is to skin nonirritant and anaphylaxis; Moisten through randomly drawing healthy subjects use feeling hand skin, smooth, there is not the decortication phenomenon.
The specific embodiment
Embodiment 1: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
26.5 parts in surfactant, 1 part of Chinese herbal medicine extract, 4.05 parts of adjuvant, 68.45 parts of purified water;
Described Chinese herbal medicine extract is formulated by weight by following raw materials according:
Weight percent concentration is 0.4 part of 85% a Oleum Cinnamomi;
Weight percent concentration is 0.1 part of 85% a Oleum Caryophylli;
0.5 part in olive oil.
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 12 parts of 35% α-Xi Jihuangsuanyans;
Weight percent concentration is 8 parts of 70% polyoxyethylenated alcohol sodium sulfate;
Weight percent concentration is 5 parts of 30% amine oxides;
Fatty alcohol-polyoxyethylene ether-9 1 part;
0.5 part of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant is formulated by weight by following raw materials according:
0.2 part of disodiumedetate;
0.8 part in carbamide;
0.55 part of citric acid;
2.5 parts in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to above-mentioned weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required surfactant successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Chinese herbal medicine extract and stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
Embodiment 2: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
21 parts in surfactant, 3 parts of Chinese herbal medicine extracts, 3.6 parts of adjuvant, 72.4 parts of purified water;
Described Chinese herbal medicine extract is formulated by weight by following raw materials according:
Weight percent concentration is 1.5 parts of 85% Oleum Cinnamomi;
1 part in olive oil;
0.5 part of Oleum Vitis viniferae.
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 15 parts of 35% α-Xi Jihuangsuanyans;
Fatty alcohol-polyoxyethylene ether-9 5 part;
1 part of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant comprises the following raw material of preparation by weight:
0.4 part of disodiumedetate;
1 part in carbamide;
0.5 part of citric acid;
1.7 parts in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to said weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required α-Xi Jihuangsuanyan, fatty alcohol-polyoxyethylene ether-9, Cortex cocois radicis oleoyl diethanolamine successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Oleum Cinnamomi, olive oil, Oleum Vitis viniferae and stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
Embodiment 3: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
22.8 parts in surfactant, 5.7 parts of Chinese herbal medicine extracts, 3.15 parts of adjuvant, 68.35 parts of purified water;
Described Chinese herbal medicine extract is formulated by weight by following raw materials according:
Weight percent concentration is 4 parts of 85% Oleum Cinnamomi;
Weight percent concentration is 0.5 part of 85% a Oleum Caryophylli;
1.2 parts in olive oil;
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 16 parts of 35% α-Xi Jihuangsuanyans;
Weight percent concentration is 5 parts of 30% amine oxides;
Fatty alcohol-polyoxyethylene ether-9 1 part;
0.8 part of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant comprises the following raw material of preparation by weight:
0.3 part of disodiumedetate;
0.8 part in carbamide;
0.45 part of citric acid;
1.6 parts in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to said weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required α-Xi Jihuangsuanyan, amine oxide, fatty alcohol-polyoxyethylene ether-9 and Cortex cocois radicis oleoyl diethanolamine successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Oleum Cinnamomi, Oleum Caryophylli and olive oil, stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
Embodiment 4: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
30 parts in surfactant, 0.5 part of Chinese herbal medicine extract, 8 parts of adjuvant, 40 parts of purified water;
Described Chinese herbal medicine extract is formulated by weight by following raw materials according:
Weight percent concentration is 0.1 part of 85% a Oleum Cinnamomi;
Weight percent concentration is 0.3 part of 85% a Oleum Caryophylli;
0.1 part in olive oil.
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 20 parts of 35% α-Xi Jihuangsuanyans;
Weight percent concentration is 1.9 parts of 70% polyoxyethylenated alcohol sodium sulfate;
Fatty alcohol-polyoxyethylene ether-9 8 part;
0.1 part of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant comprises the following raw material of preparation by weight:
2 parts of disodiumedetates;
3 parts in carbamide;
2 parts of citric acids;
1 part in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to said weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required α-Xi Jihuangsuanyan, polyoxyethylenated alcohol sodium sulfate, fatty alcohol-polyoxyethylene ether-9 and Cortex cocois radicis oleoyl diethanolamine successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Oleum Cinnamomi, Oleum Caryophylli and olive oil, stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
Embodiment 5: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
10 parts in surfactant, 12 parts of Chinese herbal medicine extracts, 2.5 parts of adjuvant, 85 parts of purified water;
Described Chinese herbal medicine extract is formulated by weight by following raw materials according:
Weight percent concentration is 8 parts of 85% Oleum Cinnamomi;
Weight percent concentration is 3 parts of 85% Oleum Caryophyllis;
1 part of Oleum Vitis viniferae.
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 5 parts of 35% α-Xi Jihuangsuanyans;
Weight percent concentration is 1.5 parts of 70% polyoxyethylenated alcohol sodium sulfate;
Fatty alcohol-polyoxyethylene ether-9 0.5 part;
3 parts of Cortex cocois radicis oleoyl diethanolamine.
Described adjuvant comprises the following raw material of preparation by weight:
1.8 parts of disodiumedetates;
0.1 part in carbamide;
0.1 part of citric acid;
0.5 part in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to said weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required α-Xi Jihuangsuanyan, polyoxyethylenated alcohol sodium sulfate, fatty alcohol-polyoxyethylene ether-9, Cortex cocois radicis oleoyl diethanolamine successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Oleum Cinnamomi, Oleum Caryophylli, Oleum Vitis viniferae, stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product.
Embodiment 6: the Chinese herbal medicine skin care type natural bacteriostatic hand sanitizer, following by weight ratio:
25 parts in surfactant, 7.6 parts of Chinese herbal medicine extracts, 8 parts of adjuvant, 60 parts of purified water;
Described Chinese herbal medicine extract is by formulated by weight in the following raw materials according:
Weight percent concentration is 0.1 part of 85% a Oleum Caryophylli;
5 parts in olive oil;
2.5 parts of Oleum Vitis viniferaes.
Described surfactant is formulated by weight by following raw materials according:
Weight percent concentration is 5 parts of 35% α-Xi Jihuangsuanyans;
Weight percent concentration is 10 parts of 70% polyoxyethylenated alcohol sodium sulfate;
Weight percent concentration is 10 parts of 30% amine oxides.
Described adjuvant comprises the following raw material of preparation by weight:
0.1 part of disodiumedetate;
0.6 part in carbamide;
0.3 part of citric acid;
7 parts in sodium chloride.
Described purified water is a kind of in distilled water, ion exchange water, the reverse osmosis water.
A kind of method for preparing above-mentioned handwashing liquid, described method for preparing comprises the following steps:
The first step: prepare needed raw material according to said weight portion, get 85% of the required purification water yield, be warmed to 50~55 ℃;
Second step: under stirring condition, add required α-Xi Jihuangsuanyan, polyoxyethylenated alcohol sodium sulfate and amine oxide successively, stirring makes it to dissolve fully;
The 3rd step: add disodiumedetate required in the adjuvant, carbamide again and make it dissolving, add remaining purified water, while stirring cooling;
The 4th step: when treating that temperature is reduced to 30~35 ℃, add required Oleum Caryophylli, olive oil and Oleum Vitis viniferae, stir;
The 5th step: with the citric acid described in the adjuvant with the 4th go on foot mixed liquor pH value transfer to 5.5~6.5;
The 6th step: add sodium chloride at last and regulate denseness, the fill that stirs gets final product
It more than is most preferred embodiment disclosed by the invention; But it will be appreciated by those skilled in the art that: in the spirit and scope that do not break away from the present invention and appended claim; Various replacements, variation and modification all are possible; Therefore, the present invention should not be limited to the disclosed content of this most preferred embodiment.