CN103271985B - A kind of skin mucosa disinfecting agent - Google Patents
A kind of skin mucosa disinfecting agent Download PDFInfo
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- CN103271985B CN103271985B CN201310236369.8A CN201310236369A CN103271985B CN 103271985 B CN103271985 B CN 103271985B CN 201310236369 A CN201310236369 A CN 201310236369A CN 103271985 B CN103271985 B CN 103271985B
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- Prior art keywords
- disinfectant
- quaternary ammonium
- ammonium salt
- liquid
- flos lonicerae
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 48
- 210000004877 mucosa Anatomy 0.000 title abstract description 8
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 15
- 241000628997 Flos Species 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000001354 calcination Methods 0.000 claims abstract description 10
- 150000002576 ketones Chemical class 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 23
- 238000012360 testing method Methods 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 5
- 241000237536 Mytilus edulis Species 0.000 claims description 4
- 235000020638 mussel Nutrition 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000001556 precipitation Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- 241000894006 Bacteria Species 0.000 abstract description 9
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 9
- 241000700605 Viruses Species 0.000 abstract description 5
- 210000004400 mucous membrane Anatomy 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000002552 dosage form Substances 0.000 abstract description 3
- 230000037311 normal skin Effects 0.000 abstract description 3
- 241000701161 unidentified adenovirus Species 0.000 abstract description 3
- 241000712461 unidentified influenza virus Species 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 208000026935 allergic disease Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 230000003211 malignant effect Effects 0.000 abstract description 2
- 244000000010 microbial pathogen Species 0.000 abstract description 2
- 235000015598 salt intake Nutrition 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 19
- 241000191967 Staphylococcus aureus Species 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 229940023064 escherichia coli Drugs 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 206010064097 avian influenza Diseases 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000003113 dilution method Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 239000008233 hard water Substances 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000565675 Oncomelania Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 231100000631 Secondary poisoning Toxicity 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000037797 influenza A Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of skin mucosa disinfecting agent, comprises the ketone extract of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae; The powder obtained after shell calcining; And double-chain quaternary ammonium salt; Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and the ketone extract of Radix Glycyrrhizae, the powder of the rear acquisition of shell calcining and double-chain quaternary ammonium salt are mixed in aqueous, is then prepared as the dosage form of needs.Disinfectant of the present invention has the function of quick-acting, long-acting, broad spectrum kill antibacterial, virus (such as influenza virus), adenovirus and malignant bacteria, can not injured skin, and mucosal tissue, to normal skin, mucosal tissue without any allergy and stimulation.This disinfectant can kill 99% pathogenic microorganism (virus, antibacterial) in 5 seconds, continued the antibacterial time long, and this disinfectant quaternary ammonium salt consumption is conventional 10-20%, more secure when used to mucosa.Compared with independent applicable quaternary ammonium salt disinfectant, effect improves 10-15 doubly, and product LD50 improves more than 5-10 times.
Description
Technical field
The present invention relates to a kind of disinfectant, be applicable to the exterminating bacterium sterilization of the aspects such as normal skin, mucosal tissue, health and epidemic prevention.It can kill various virus (such as influenza virus), antibacterial, harmful microorganism effectively, is a kind of effective health mean of defense of pre-preventing germs infection (such as flu-prevention).
Background technology
Common people after living through the epidemic situation such as " SARS ", " bird flu ", " hand-foot-mouth disease ", " influenza A ", " H7N9 influenza " are more and more stronger for the consciousness that sterilization is degerming, along with the development of health science, become with the sterilization contacting general patient demographic is degerming the inevitable requisite measure cutting off route of transmission for patient.But traditional disinfection agent usually has certain toxicity and remains, life-time service to humans and animals generation injury (secondary poisoning) in various degree, and can cause severe contamination to environment.So a kind of safety of preparation, efficient disinfectant are for influenza, the control and prevention of bird flu is extremely important.
Summary of the invention
The present invention relates to a kind of new disinfectant (particularly skin, mucosa disinfectant), its preparation method and purposes.
Disinfectant of the present invention comprises: the ketone extract of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae; The powder obtained after shell calcining; And double-chain quaternary ammonium salt.Wherein, the weight ratio of described Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae can be 1-5:1-5:1-5:1-20, is preferably 1:1:1:4.In one embodiment, the weight of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae is respectively 30g, 30g, 30g and 120g.Described ketone can be acetone.Wherein said shell can be mussel and/or abalone shells.Described shell calcining is preferably carried out under 1100-1200 degree Celsius.The powder obtained after described shell calcining is containing calcium hydroxide.
In one embodiment, disinfectant of the present invention also can comprise the compositions such as other antimicrobial activity composition, buffer agent and/or excipient.
Open-ended term such as " comprising ", " comprising " of using in the present invention also contemplated " by ... composition " situation.
Disinfectant of the present invention can be the dosage forms such as spray, powder agent, solution.
Disinfectant of the present invention can be prepared by following method: Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and the ketone extract of Radix Glycyrrhizae, the powder of the rear acquisition of shell calcining and double-chain quaternary ammonium salt are mixed in aqueous, be then prepared as the dosage form of needs.
In one embodiment, disinfectant of the present invention can be prepared by following method: added water and make A liquid (in one embodiment by the acetone extract (such as adding 1000 milliliters, acetone to extract) of Radix Sophorae Flavescentis 30g Fructus Cnidii 30g Flos Lonicerae 30g Radix Glycyrrhizae 120g, the described water added can be 10000ml-12000ml), shell (such as mussel) is removed precipitation after powder water-soluble half an hour that high temperature 1100-1200 degree Celsius of calcining obtains and slowly adds A liquid, test is regulated to be 7.8-8.3 to pH value, obtain B liquid, double-chain quaternary ammonium salt is added B liquid and obtain C liquid (in one embodiment, double-chain quaternary ammonium salt concentration is 1%-3%), C liquid is detected and is distributed into finished product.
The invention still further relates to Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae, Radix Glycyrrhizae, shell powder and the double-chain quaternary ammonium salt purposes in preparation disinfectant.In one embodiment, described disinfectant is skin and/or mucosa disinfectant.In one embodiment, described disinfectant is used for prevention and/or kills escherichia coli and/or staphylococcus aureus bacterium.
Described disinfectant can be used in skin, mucosa by Direct spraying, also can add handwashing liquid and use, and also may be used for the thing table disinfectant such as wet paper towel, process film forming mask, the disposable contact gloves of film former, liquid detergent, air and handguard seat, floor.
Disinfectant of the present invention has the function of quick-acting, long-acting, broad spectrum kill antibacterial, virus (such as influenza virus), adenovirus and malignant bacteria, can not injured skin, and mucosal tissue, to normal skin, mucosal tissue without any allergy and stimulation.This disinfectant can kill 99% pathogenic microorganism (virus, antibacterial) in 5 seconds, continued the antibacterial time long, and this disinfectant quaternary ammonium salt consumption is conventional 10-20%, more secure when used to mucosa.Compared with independent applicable quaternary ammonium salt disinfectant, effect improves 10-15 doubly, and product LD50 improves more than 5-10 times.
Detailed description of the invention
The present invention is described further by following examples.
Experiment material.
One: experimental strain.
1.Escherichiacoli dust Xi Shi escherichia coli (8099).
2.Staphylococcusaureus staphylococcus aureus (ATCC6538).
3.Aspergillusniger adenovirus.
Being prepared into 1X108cfu/ml is bacteria suspension.
Two: nertralizer and culture medium.
Nertralizer is for containing 10g/L histidine, 3g/L lecithin, the phosphate buffer of 3% tween 80.Through nertralizer identification experiment, selected nertralizer and concentration thereof are all suitable.Culture medium: M-H Nutrient agar.
Three: disinfectant of the present invention (liquid).
By Radix Sophorae Flavescentis 30g, Fructus Cnidii 30g, Flos Lonicerae 30g, the acetone extract of Radix Glycyrrhizae 120g adds 10000 parts of water and makes A liquid, the powder that the shells such as mussel obtain through high temperature 1100-1200 degree Celsius of calcining is added A liquid, and adjustment pH value is 7.8-8.3, obtains B liquid, double-chain quaternary ammonium salt is added B liquid and obtain C liquid, C liquid is detected subpackage and namely obtains disinfectant solution of the present invention.
Experimental technique.
In and dilution method: disinfectant solution stock solution standard hard water of the present invention is pressed 1:9(disinfectant solution: standard hard water) dilution, simultaneously negative control is nertralizer solution, and positive control is Beaune nurse disinfectant solution, and both also press corresponding proportion and dilute.Action time is 1 minute, and experimental temperature is 20+/-1.Experiment repetition 3 times.
Quantifying Bacteria is tested: experiment adopts suspension method, and experimental strain, as above-mentioned, all makes the bacteria suspension of ordinary broth.The test tube filling 4.5ml variable concentrations disinfectant solution or negative control (phosphate acid buffer) is placed in 20 water-bath preheatings respectively, gets bacterium liquid 0.5ml and add in disinfectant solution, mixing is placed in 20 water-baths and acts on 5 minutes.Get 0.5ml bacterium medicine mixed liquor to add in the test tube that 4.5ml nertralizer is housed and mix.Neutralization 10 minutes, carries out count plate, calculates killing rate.
Sterilization experiment: by the present invention and Beaune nurse disinfectant solution stock solution, action time is 1 minute, and experimental temperature is 20+/-1, experiment repetition 3 times.
Experimental result:
1. nertralizer qualification test.
(1) prove through 3 repeated trials, 1 group of average production clump count is 0cfu/ml, and 2 groups is 0cfu/ml.3 groups, 4 groups and 5 groups of average colony numbers are respectively 17480000cfu/ml, 16730000cfu/ml and 1730000cfu/ml, and between three groups, error rate is 2.90%(table 1).In showing to adopt and dilution method and nertralizer used effectively can neutralize and add disinfectant solution stock solution of the present invention, and nertralizer solution and neutralized reaction product solution on the growth of staphylococcus aureus substantially without affecting.
Table 1 nertralizer authentication test results
2. bactericidal effect.
Prove through sterilization experiment, 10% disinfectant solution of the present invention and Beaune nurse disinfectant solution are diluted 1000 times respectively, respectively with escherichia coli, the effect of staphylococcus aureus bacteria suspension 5 minutes, to both killing rate all more than 99.9% (table 2).(in table, first and second represent identical Beaune nurse disinfectant solution, third and fourth represent identical disinfectant solution of the present invention).
Table 2 disinfectant is to the killing effect of colibacillus
Note: test temperature is 20 DEG C, matched group colibacillus is 6.28 × 10
7cFU/ml.
Result is 5 test meansigma methodss.
Table 3 disinfectant is to the killing effect of staphylococcus aureus
Note: test temperature is 20 DEG C, matched group staphylococcus aureus is 6.3 × 10
7cFU/ml.
Result is 5 test meansigma methodss.
Under test temperature 20 DEG C ± 1 DEG C condition, prove through 3 repeated trials, add disinfectant solution stock solution effect 1.0min of the present invention, to staphylococcus aureus kill oncomelania >5.00(table 4).
Table 4 adds the killing effect of disinfectant solution of the present invention to staphylococcus aureus
Note: the average bacterium number of positive control and scope: 17730000cfu/ml (12900000cfu) ≈ 20800000cfu/ml).
Above-mentioned result of the test illustrates, the bactericidal effect of disinfectant solution of the present invention is significantly better than disinfectant commercial in prior art.
Claims (2)
1. a preparation method for disinfectant, is characterized in that: this disinfectant is made up of following raw material: the ketone extract of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae, the powder obtained after shell calcining, and double-chain quaternary ammonium salt; Wherein the weight ratio of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae and Radix Glycyrrhizae is 1-5:1-5:1-5:1-20; In described ratio, the acetone extract of Radix Sophorae Flavescentis, Fructus Cnidii, Flos Lonicerae, Radix Glycyrrhizae is added 40-50 water doubly and make A liquid, mussel is removed precipitation after powder water-soluble half an hour that high temperature 1100-1200 degree Celsius of calcining obtains and slowly adds A liquid, test is regulated to be 7.8-8.3 to pH value, obtain B liquid, double-chain quaternary ammonium salt is added B liquid and obtain C liquid, the concentration of double-chain quaternary ammonium salt in C liquid is 1%-3%, is detected by C liquid and is distributed into finished product.
2. the preparation method of disinfectant according to claim 1, is characterized in that described Radix Sophorae Flavescentis, Fructus Cnidii, the weight ratio of Flos Lonicerae and Radix Glycyrrhizae is 1:1:1:4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310236369.8A CN103271985B (en) | 2013-06-14 | 2013-06-14 | A kind of skin mucosa disinfecting agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310236369.8A CN103271985B (en) | 2013-06-14 | 2013-06-14 | A kind of skin mucosa disinfecting agent |
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| Publication Number | Publication Date |
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| CN103271985A CN103271985A (en) | 2013-09-04 |
| CN103271985B true CN103271985B (en) | 2016-02-24 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103828846B (en) * | 2014-03-21 | 2016-08-31 | 广州中大药物开发有限公司 | A kind of bactericidal composition and its preparation method and application |
| CN105943646A (en) * | 2016-06-08 | 2016-09-21 | 淄博神威药业有限公司 | Multifunctional traditional Chinese medicine liquid capable of achieving disinfection, killing germs and stopping bleeding |
| CN109172634A (en) * | 2018-11-19 | 2019-01-11 | 邱子恒 | A kind of skin mucosa disinfectant and preparation method thereof for wound healing |
| CN111298059A (en) * | 2020-03-18 | 2020-06-19 | 湖南宝护者生物技术有限公司 | Skin mucosa disinfectant prepared from Chinese herbal medicines and preparation method thereof |
| CN111329899A (en) * | 2020-03-18 | 2020-06-26 | 湖南宝护者生物技术有限公司 | Skin mucosa disinfectant and using method thereof |
| CN111317770A (en) * | 2020-04-16 | 2020-06-23 | 北海添灏生物科技有限公司 | Antibacterial liquid |
| CN112205425A (en) * | 2020-10-13 | 2021-01-12 | 湖南弘烨医疗器械有限公司 | Novel medical disinfection wet tissue and manufacturing method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101401592A (en) * | 2008-11-03 | 2009-04-08 | 中国检验检疫科学研究院 | Extracting method for kuh-seng disinfection composition and sanitizer containing the kuh-seng disinfection composition |
| CN102754668A (en) * | 2011-04-27 | 2012-10-31 | 崔瑛 | Novel Chinese herbal medicine compound disinfectant solution |
| CN103054969B (en) * | 2013-02-06 | 2014-08-13 | 山东省立医院 | Compound skin disinfectant and preparation method thereof |
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