CN111329899A - Skin mucosa disinfectant and using method thereof - Google Patents

Skin mucosa disinfectant and using method thereof Download PDF

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Publication number
CN111329899A
CN111329899A CN202010193256.4A CN202010193256A CN111329899A CN 111329899 A CN111329899 A CN 111329899A CN 202010193256 A CN202010193256 A CN 202010193256A CN 111329899 A CN111329899 A CN 111329899A
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skin
disinfectant
powder
dimethyl ammonium
didecyl dimethyl
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蒋斌
肖善良
龚志贤
李四海
于勇
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Hunan Baobaozhe Biotechnology Co ltd
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Hunan Baobaozhe Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
    • A61K36/355Lonicera (honeysuckle)
    • AHUMAN NECESSITIES
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    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

The invention relates to the technical field of disinfectants, in particular to a skin mucosa disinfectant and a using method thereof, and the skin mucosa disinfectant comprises the following components of double-chain quaternary ammonium salt compounds (didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride), honeysuckle, liquorice, forsythia, sophora flavescens, plantain, rhizoma atractylodis, astragalus, dandelion, purslane, clove and deionized water, wherein each part of the skin mucosa disinfectant comprises 10-30 ml of deionized water, and skin and mucosa are the first defense line for resisting infection of a human body, so that the disinfection of the skin mucosa is important.

Description

Skin mucosa disinfectant and using method thereof
Technical Field
The invention relates to the technical field of disinfection and epidemic prevention, in particular to a skin mucosa disinfectant and a preparation method thereof.
Background
The skin is parasitized with various microorganisms, including various bacterial propagules, fungi, germs and the like, especially the skin of hands, because the skin has more chances of contacting articles and most varieties and quantities of polluted microorganisms, viruses such as hand-foot-mouth disease, flu, mumps, rotavirus, SARS and the like are easy to spread in the hands and mouths, especially the bacterial pollution of the hands of medical care personnel is more serious, and if the disinfection is not thorough, the skin can bring disease hidden troubles to the hands, patients and families.
The skin and the mucous membrane protect the human body, so that the human body forms a closed system to the outside, and when harmful substances are about to invade the human body, the skin and the mucous membrane firstly block the outside pathogenic factors outside the human body. Therefore, the skin and the mucous membrane are the first defense line of the human body against infection, and the disinfection of the skin and the mucous membrane is important.
There are two methods of traditional skin disinfection: soap flow hand washing and chemical disinfectant disinfection. The soap disinfection is widely applied, but has some defects, such as weak disinfection capability of boric acid disinfection soap and poor effect on viruses and parasites; the phenolic disinfectant soap has strong skin irritation, is not suitable for people with sensitive skin and small wounds, and has poor effect of killing fungi; the sulfur disinfectant soap has the defects of strong sebum secretion inhibiting effect and dry skin after use. The chemical disinfectants are usually chlorhexidine, iodine, alcohol, glutaraldehyde and the like, have respective advantages and disadvantages and cannot comprehensively and effectively disinfect and sterilize. Most of the skin disinfection liquids are chemical compounds, such as iodine-containing preparations, alcohol disinfectants and the like, which have poor stability and large irritation to human bodies and have certain potential hazard to the human bodies after long-term use.
At present, many families raise pets, but when people and pets play with the pets, the animals can scratch or bite the pets carelessly, a disease control center specialist shows that the standard wound treatment, the inoculation of rabies vaccines and the injection of rabies immune globulin are the main methods for effectively preventing rabies, particularly, the standard wound treatment is more effective than the vaccination in a certain sense, citizens do not treat wounds after being scratched or bitten by the pets, and rush to prevent the disease, but the method is wrong, the wounds need to be treated at the first time, the wounds can be cleaned by soap in a running water state, the wounds are disinfected by alcohol in a conditional way, and about 60% of viruses can be blocked in the mode. Of course, after the wound is treated, the patient should come to a health institution to take a doctor in time.
Disclosure of Invention
The invention provides a skin mucosa disinfectant prepared by Chinese herbal medicines, which is applicable to disinfection and sterilization of normal skin, mucosa tissues, epidemic prevention and the like.
The basic scheme provided by the invention is as follows: a skin and mucosa disinfectant comprises ketone extracts of double-chain quaternary ammonium salt compound, flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, flos Caryophylli, and herba Menthae.
The double-chain quaternary ammonium salt compound has the action mechanism that ① changes the permeability of cells and water enters to swell and break the thalli, ② has good surface activity and can be highly gathered on the surface of the thalli to influence the metabolism of bacteria, ③ enables protein denaturation, ④ inactivates dehydrogenase and oxidase in bacterial cells, and enzyme systems capable of decomposing glucose, succinate (Suecinate), Pyruvate (Pyruvate) and the like interfere the synthesis of protein and nucleic acid to further influence the energy metabolism of the cells, so that the processes of biological oxidation, respiratory metabolism, energy generation and the like are blocked, and finally the microorganisms die.
Preferably, the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride.
Didecyl dimethyl ammonium bromide: a quaternary ammonium salt cationic surfactant is a light yellow transparent liquid, has poor water solubility, and has antibacterial and disinfectant effects.
Didecyl dimethyl ammonium chloride: didecyl dimethyl ammonium chloride, namely decyl methyl ammonium chloride, didecyl dimethyl ammonium chloride and the like is a cationic surfactant, is a light yellow transparent liquid at normal temperature, is easy to dissolve in water and organic solvents, and has stable chemical properties and small irritation.
Preferably, according to the weight part ratio, each part of the skin mucosa disinfectant is prepared according to the following weight part ratio, 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride, 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain, 1-3 mg of dandelion, 2-3 mg of nux vomica, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis, 1-3 mg of fructus forsythiae and 0.4-0.6 mg of ketone extract of mint.
Preferably, the disinfectant also comprises deionized water, and each part of the disinfectant for skin mucosa comprises 10ml to 30ml of deionized water.
The invention also provides a using method of the skin mucosa disinfectant, and the application of the skin mucosa disinfectant in killing viruses, bacteria and fungi on the surfaces of skin, hands and objects.
Preferably, the skin disinfectant is smeared on the surface of the skin to be disinfected by a medical cotton swab or sprayed on the surface of the skin to be disinfected by a spray bottle, and the skin mucous membrane disinfectant stays on the skin for more than three minutes and can be washed away by clear water or soapy water. (ii) a
Preferably, when the skin disinfection solution is used for disinfecting viruses in the oral cavity, 5-10 ml of the virus is taken by a measuring cup and poured into the oral cavity, the virus stays in the oral cavity for more than three minutes and then is spit out, and then the virus is rinsed with clear water.
The invention also provides a preparation method of the skin mucosa disinfectant, which comprises the following steps:
(1) preparing honeysuckle, liquorice, fructus forsythiae, radix sophorae flavescentis, plantain, rhizoma atractylodis, radix astragali, dandelion, mallotus and clove, wherein the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride;
(2) preparing a plurality of containers with covers, and sterilizing and drying the containers;
(3) preparing purified water, distilling the purified water by using a distiller to obtain deionized water, and filling the obtained deionized water into the container obtained by the treatment in the step (2);
(4) cleaning flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, flos Caryophylli, and herba Menthae with clear water, air drying, grinding flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, and flos Caryophylli respectively to powder, extracting ketone extract from herba Menthae, and packaging the obtained flos Lonicerae powder, Glycyrrhrizae radix powder, radix Sophorae Flavescentis powder, radix astragali powder, herba plantaginis powder, rhizoma Atractylodis powder, herba Taraxaci powder, herba Portulacae powder, flos Caryophylli powder and fructus forsythiae powder in sterilized and dried containers respectively;
(5) according to the weight portion ratio, each part of the skin mucosa disinfectant is prepared according to the following weight portion ratio: 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain, 1-3 mg of dandelion, 2-3 mg of masson weed, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis and 1-3 mg of fructus forsythiae, placing all the powders in a container, uniformly mixing, adding ethanol liquid with concentration being seventy-five percent, which is twice of the weight of all the powders, uniformly stirring to obtain a pasty mixture, then standing for 12 hours in an open manner to volatilize the ethanol liquid, and filtering by using a plurality of layers of medical gauzes to obtain an extracting solution A;
(6) filtering the mixture obtained in the step (5) by using medical filter paper, filling filter residues obtained by filtering into a sterilized and dried container, adding the menthone extract according to the weight ratio, adding deionized water, and uniformly mixing to obtain a solution B;
(7) adding a double-chain quaternary ammonium salt compound into each part of skin mucosa disinfectant according to the content of 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride in the skin mucosa disinfectant, adding the obtained didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride into filter residue obtained by filtering, heating, continuously stirring in the heating process, adding deionized water, controlling the heating temperature to be 79-90 ℃, heating for 10min, naturally cooling, and filtering by using a plurality of layers of medical gauze to obtain a finished product. .
1. The skin mucosa disinfectant provided by the invention is rich in plant extract essences such as honeysuckle, sophora flavescens and the like, can kill fungi, escherichia coli, staphylococcus aureus, candida albicans, natural skin bacteria, inactivated viruses, bacterial spores, bacterial propagules and the like, and can be regarded as a brand new generation of broad-spectrum, efficient and safe antibacterial agent and skin mucosa disinfectant.
2. The skin mucosa disinfectant provided by the invention has strong sterilization performance, can effectively kill viruses, has good stability, is safe and non-irritant, and is beneficial to promoting wound healing.
Drawings
FIG. 1 is a data record table (record one) of the skin mucosa disinfectant experiment of the present invention;
FIG. 2 is a data record table (record two) of the skin mucosa disinfectant experiment of the present invention;
FIG. 3 is a perspective view of the apparatus for manufacturing a disinfectant for skin mucosa according to the present invention;
FIG. 4 is a top view of the crushing device of the apparatus for manufacturing a disinfectant for skin mucosa according to the present invention;
FIG. 5 is a perspective view of a bottle filling system of the apparatus for manufacturing a disinfectant for skin mucosa according to the present invention;
FIG. 6 is a perspective view of a rotating mechanism of the apparatus for manufacturing a disinfectant for skin mucosa according to the present invention;
fig. 7 is a front view of a rotating mechanism of the apparatus for manufacturing a skin mucosa disinfectant according to the present invention.
Wherein reference numerals referred to in the drawings include: the device comprises a crushing device 1, a crushing space 101, a crushing roller 102, a rotating shaft 103, a driving motor 105, a supporting plate 2, a conveying pipe 3, a water conveying pipe 401, a medicine conveying pipe 402, a water conveying device 403, a medicine conveying device 404, a first motor 405, a second motor 406, a mixing box 6, a filter box 7, a bottling system 8, a supporting frame 801, an extruding pipe 802, a moving plate 805, a spring 806, a capping mechanism 9, a servo motor 901, a rotating structure 903, a containing groove 904, a rotating shaft 905, a driving rod 906, a driving wheel 907, a driving wheel 908 and medicine bottles 10.
Detailed Description
The following is further detailed by the specific embodiments:
a skin mucosa disinfectant comprises double-chain quaternary ammonium salt compound, flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, and flos Caryophylli, the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride, according to the weight part ratio, each part of skin mucosa disinfectant is prepared according to the following weight part ratio, 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride, 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain herb, 1-3 mg of dandelion, 2-3 mg of nux vomica, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis, 1-3 mg of fructus forsythiae, deionized water is further included in the skin mucosa disinfectant, and each part of skin mucosa disinfectant comprises 10-30 ml of deionized water.
The double-chain quaternary ammonium salt compound has the action mechanism that ① changes the permeability of cells and water enters to swell and break the thalli, ② has good surface activity and can be highly gathered on the surface of the thalli to influence the metabolism of bacteria, ③ enables protein denaturation, ④ inactivates dehydrogenase and oxidase in bacterial cells, and enzyme systems capable of decomposing glucose, succinate (Suecinate), Pyruvate (Pyruvate) and the like interfere the synthesis of protein and nucleic acid to further influence the energy metabolism of the cells, so that the processes of biological oxidation, respiratory metabolism, energy generation and the like are blocked, and finally the microorganisms die.
Preferably, the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride.
Didecyl dimethyl ammonium bromide: a quaternary ammonium salt cationic surfactant is a light yellow transparent liquid, has poor water solubility, and has antibacterial and disinfectant effects.
Didecyl dimethyl ammonium chloride: didecyl dimethyl ammonium chloride, namely decyl methyl ammonium chloride, didecyl dimethyl ammonium chloride and the like is a cationic surfactant, is a light yellow transparent liquid at normal temperature, is easy to dissolve in water and organic solvents, and has stable chemical properties and small irritation.
Toxicology of honeysuckle: 1. resisting pathogenic microorganism, resisting inflammation and relieving fever, and enhancing immunity.
Licorice can be used to harmonize the potency of certain drugs.
The sophora flavescens is bitter and cold, has the effects of clearing heat and drying dampness, killing parasites and promoting urination, and is used for treating dysentery with fever, hematochezia, jaundice anuresis, leucorrhea with reddish discharge, swelling and itching vulva, eczema, skin pruritus, mange and leprosy and externally treating trichomonas vaginitis.
Plantain herb: sweet taste and cold nature, and has effects of promoting urination, clearing heat away, improving eyesight, and eliminating phlegm. Can be used for treating urinary obstruction, stranguria with turbid urine, leukorrhagia, hematuria, jaundice, edema, dysentery, diarrhea, epistaxis, conjunctival congestion, sore throat, cough, skin ulcer, etc.
Dandelion: contains taraxasterol, choline, inulin, pectin, etc., and has antibacterial effect: the injection has strong bactericidal effect on Staphylococcus aureus resistant strains and hemolytic streptococcus in test tubes, also has bactericidal effect on Diplococcus pneumoniae, meningococcus, diphtheria bacillus, Pseudomonas aeruginosa, Shigella dysenteriae, Salmonella typhi and other bacteria and on Catalpa coccus, also has inhibitory effect on certain fungi, and has good killing effect on Campylobacter pylori.
Rhizoma atractylodis: the atractylodes rhizome has the functions of resisting ulcer, tumor, virus and bacteria, and the research shows that the atractylodes rhizome can kill some pathogenic bacteria in the smoked room when burned.
Astragalus root: the main chemical components of astragalus root include astragalus polysaccharide, saponin, flavone and amino acid, and the pharmacological action is to raise immunity, strengthen antioxidation, antiradiation and anticancer action, protect cardiac and cerebral blood vessels, liver, kidney and lung, protect brain cell, raise memory, relax blood vessel smooth muscle, hormone-like action, resist bacteria and inhibit virus.
Clove: has strong inhibiting effect on Brucella and avian tuberculosis, has remarkable inhibiting effect on common disease-treating dermatophytes, has no irritation to skin, and has good absorption.
Foraging by malpighia: the horse has the functions of clearing away heat and toxic materials, cooling blood, stopping bleeding, removing blood stasis and relieving swelling. Folk medicine is often used to treat enteritis, dysentery and other diseases.
The double-chain quaternary ammonium salt compound has better water solubility and good capability of reducing surface tension, and also has the function of resisting adverse effects of anionic surfactants, hard water, protein organic matters and the like; in addition, the foam is little, the influence of water quality is small, and a good sterilization effect can be maintained.
The skin mucosa disinfectant provided by the invention is rich in plant extract essences such as honeysuckle, sophora flavescens and the like, can kill fungi, escherichia coli, staphylococcus aureus, candida albicans, natural skin bacteria, inactivated viruses, bacterial spores, bacterial propagules and the like, and can be regarded as a brand new generation of broad-spectrum, efficient and safe antibacterial agent and skin mucosa disinfectant.
The skin mucosa disinfectant provided by the invention has strong bactericidal performance, can effectively kill hydrophilic viruses, has good stability, is safe and non-irritant, and is beneficial to promoting wound healing.
A method for using a skin mucosa disinfectant is disclosed, which is used for killing viruses, bacteria and fungi on the surfaces of skin, hands and objects.
The skin disinfectant is smeared on the surface of skin to be disinfected by a medical cotton swab or sprayed on the surface of the skin to be disinfected by a spray bottle, and the skin mucous membrane disinfectant stays on the skin for more than three minutes and can be washed away by clear water or soapy water.
When the skin disinfectant is used for disinfecting viruses in the oral cavity, 5-10 ml of the skin disinfectant is taken by a measuring cup and poured into the oral cavity, the skin disinfectant stays in the oral cavity for more than three minutes and then is spit out, and then the oral cavity is rinsed with clear water.
A preparation method of a skin mucosa disinfectant comprises the following steps:
(1) preparing honeysuckle, liquorice, fructus forsythiae, radix sophorae flavescentis, plantain, rhizoma atractylodis, radix astragali, dandelion, mallotus and clove, wherein the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride;
(2) preparing a plurality of containers with covers, and sterilizing and drying the containers;
(3) preparing purified water, distilling the purified water by using a distiller to obtain deionized water, and filling the obtained deionized water into the container obtained by the treatment in the step (2);
(4) cleaning flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae and flos Caryophylli with clear water, air drying, grinding flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae and flos Caryophylli respectively to powder, and respectively packaging the obtained flos Lonicerae powder, Glycyrrhrizae radix powder, radix Sophorae Flavescentis powder, radix astragali powder, herba plantaginis powder, rhizoma Atractylodis powder, herba Taraxaci powder, herba Portulacae powder, flos Caryophylli powder and fructus forsythiae powder in sterilized and dried containers for use;
(5) according to the weight portion ratio, each part of the skin mucosa disinfectant is prepared according to the following weight portion ratio: 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain, 1-3 mg of dandelion, 2-3 mg of malpighia indica, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis and 1-3 mg of fructus forsythiae, placing all the powders in a container, uniformly mixing, adding ethanol liquid with concentration being seventy-five percent, which is twice the weight of all the powders, uniformly stirring to obtain pasty mixture, then standing for 12 hours in an open manner to volatilize the ethanol liquid, and filtering by using a plurality of layers of medical gauzes to obtain an extracting solution.
Preferably, filtering the mixture obtained in the step (5) by using medical filter paper, filling the filtered residue into a sterilized and dried container, adding the calculated didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride into the filtered residue according to the weight part ratio in the step (5), continuously stirring in the heating process, adding deionized water, controlling the heating temperature to be 79-90 ℃, naturally cooling the residue after heating for 10min, and filtering by using multilayer medical gauze to obtain an extracting solution, wherein each part of the skin mucosa disinfectant contains 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride.
The invention also provides equipment for manufacturing skin mucosa disinfectant, which comprises a crushing device 1 and a mixing device as shown in figures 2 to 7, wherein the crushing device 1 comprises a crushing box, a supporting plate 2 is installed at the bottom of the crushing box, the top of the crushing box is provided with an opening, a crushing space 101 is arranged inside the crushing box, a crushing roller 102 is installed inside the crushing box, the crushing roller 102 is installed inside the crushing space 101 of the crushing box through a rotating shaft 103, the crushing roller 102 is connected with a driving motor 105, and when the equipment is used, cleaned and aired honeysuckle, liquorice, fructus forsythiae, radix sophorae flavescentis, plantain herb, rhizoma atractylodis, radix astragali, dandelion, nux vomica and clove are put into the crushing box through the opening at the top of the crushing box and processed into honeysuckle powder, liquorice powder, radix sophorae flavescentis powder, radix astragali powder, plantain herb powder, rhizoma atractylodis powder, dandelion powder, nux vomica powder, Flos Caryophylli powder and fructus forsythiae powder, and flos Lonicerae powder, Glycyrrhrizae radix powder, radix Sophorae Flavescentis powder, radix astragali powder, herba plantaginis powder, rhizoma Atractylodis powder, herba Taraxaci powder, herba Portulacae powder, flos Caryophylli powder and fructus forsythiae powder are mixed during rotation of the pulverizing roller 102.
The bottom of the crushing box is connected with a delivery pipe 3, the delivery pipe 3 is connected with a mixing device, the mixing device comprises a water delivery device 403, a drug delivery device 404, a mixing box 6 and a filtering box 7, the water delivery device 403 is driven by a first motor 405, and the drug delivery device 404 is driven by a second motor 406; the crushing case with mixing box 6 passes through conveyer pipe 3 and connects, the inside deionized water through distillation treatment that is equipped with of water delivery device 403, water delivery device 403 pass through raceway 401 with mixing box 6 connects, medicine delivery device 404 pass through medicine delivery pipe 402 with mixing box 6 connects, mixing box 6 with rose box 7 connects, and the Chinese herbal medicine powder through crushing the mixture is carried in mixing box 6, in deionized water and double-stranded quaternary ammonium salt compound carry mixing box 6 through raceway 401 and medicine delivery pipe 402 respectively, with Chinese herbal medicine powder, deionized water and double-stranded quaternary ammonium salt compound misce bene in mixing box 6, heating filament and ultraviolet ray disinfection lamp are installed to the top in mixing box 6, in the filter box 7 is carried to the mixture that Chinese herbal medicine powder, deionized water and double-stranded quaternary ammonium salt compound misce bene obtained, a plurality of layers of filter screens are arranged in the filter box 7, solid substances and liquid substances are separated from the mixture through the filter screens, filter holes are formed in the bottom of the filter box 7, and filtrate obtained through filtering leaks out through the filter holes.
Since the mixing box 6 is provided with the heating filament and the ultraviolet ray sterilizing lamp, the steps of adding the ethanol liquid to the mixture for sterilization and volatilizing the ethanol by heating can be omitted.
The filtration pore of rose box 7 is connected with bottling system 8, and bottling system 8 includes filling mechanism and closing cap mechanism 9, primary filling mechanism and closing cap mechanism 9 pass through the conveyer and connect, and filling mechanism sets up on support frame 801, and the direction of motion of installation conveyer, filling mechanism set up the motion head end at conveying mechanism, and closing cap mechanism 9 sets up at conveying mechanism's motion end, and filling mechanism includes the transfer line of being connected with the rose box, the transfer line other end is connected with the calandria, and the calandria setting is in movable plate 805, and the bottom of calandria is connected with a plurality of extruded tubes 802, be equipped with spring 806 between the middle part of extruded tube 802 and the movable plate 805, utilize the cooperation between spring 806 and the movable plate 805 can be according to the height of medicine bottle 10, adjust the distance between the terminal and the bottleneck of medicine bottle 10 of extruded tube 802.
The capping mechanism 9 comprises a slow stopping device, the slow stopping device comprises a rotating structure 903, a plurality of accommodating grooves 904 are formed in the circumferential direction of the rotating structure 903, a rotating shaft 905 is installed in the center of the rotating structure, a driving device is connected to the lower end of the rotating shaft 905, the driving device comprises a servo motor 901, the servo motor 901 is connected with a transmission rod 906, the other end of the transmission rod 906 is fixedly connected with a driving wheel 907, a driving wheel 908 is meshed with the outside of the driving wheel 907, the driving wheel 908 is fixedly connected to the rotating shaft 905, only one sector of the driving wheel 907 is provided with meshing teeth, the angle of the sector is smaller than 180 degrees, therefore, one rotation of the driving wheel 907 is realized, the rotation angle of the driving wheel 908 is smaller than one rotation, when the driving wheel 907 rotates all the time, the driving wheel 908 does intermittent motion, and the rotating structure 903, at this time, the vial 10 in the container 904 is capped.
The foregoing is merely an example of the present invention, and common general knowledge in the field of known specific structures and characteristics is not described herein in any greater extent than that known in the art at the filing date or prior to the priority date of the application, so that those skilled in the art can now appreciate that all of the above-described techniques in this field and have the ability to apply routine experimentation before this date can be combined with one or more of the present teachings to complete and implement the present invention, and that certain typical known structures or known methods do not pose any impediments to the implementation of the present invention by those skilled in the art. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent.

Claims (8)

1. A skin mucosa disinfectant is characterized in that: comprises ketone extracts of double-chain quaternary ammonium salt compound, flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, flos Caryophylli, and herba Menthae.
2. The disinfectant liquid for skin and mucous membrane as claimed in claim 1, wherein: the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride.
3. The disinfectant liquid for skin and mucous membrane as claimed in claim 2, wherein: according to the weight part ratio, each part of skin mucosa disinfectant is prepared according to the following weight part ratio, 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride, 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain herb, 1-3 mg of dandelion, 2-3 mg of madurage, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis, 1-3 mg of fructus forsythiae and 0.4-0.6 mg of ketone extract of mint.
4. The method for preparing the disinfectant for skin mucosa according to claim 3, wherein the method comprises the following steps: also comprises deionized water, and each part of the skin mucosa disinfectant comprises 10ml to 30ml of deionized water.
5. The method for using the disinfectant solution for skin and mucous membrane as claimed in claim 4, wherein the method comprises the following steps: the skin mucosa disinfectant is used for killing viruses, bacteria and fungi on the surfaces of skin, hands and objects.
6. The method for using the disinfectant solution for skin and mucous membrane as claimed in claim 5, wherein the method comprises the following steps: the skin disinfectant is smeared on the surface of skin to be disinfected by a medical cotton swab or sprayed on the surface of the skin to be disinfected by a spray bottle, and the skin mucous membrane disinfectant stays on the skin for more than three minutes and can be washed away by clear water or soapy water.
7. The method for using the disinfectant solution for skin and mucous membrane as claimed in claim 5, wherein the method comprises the following steps: when the skin disinfectant is used for disinfecting viruses in the oral cavity, 5-10 ml of the skin disinfectant is taken by a measuring cup and poured into the oral cavity, the skin disinfectant stays in the oral cavity for more than three minutes and then is spit out, and then the oral cavity is rinsed with clear water.
8. The method for preparing the disinfectant for skin mucosa according to claim 4, wherein the method comprises the following steps: the method comprises the following steps:
(1) preparing honeysuckle, liquorice, fructus forsythiae, radix sophorae flavescentis, plantain, rhizoma atractylodis, radix astragali, dandelion, mallotus and clove, wherein the double-chain quaternary ammonium salt compound adopts didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride;
(2) preparing a plurality of containers with covers, and sterilizing and drying the containers;
(3) preparing purified water, distilling the purified water by using a distiller to obtain deionized water, and filling the obtained deionized water into the container obtained by the treatment in the step (2);
(4) cleaning flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, flos Caryophylli, and herba Menthae with clear water, air drying, grinding flos Lonicerae, Glycyrrhrizae radix, fructus forsythiae, radix Sophorae Flavescentis, herba plantaginis, rhizoma Atractylodis, radix astragali, herba Taraxaci, herba Portulacae, and flos Caryophylli respectively to powder, extracting ketone extract from herba Menthae, and packaging the obtained flos Lonicerae powder, Glycyrrhrizae radix powder, radix Sophorae Flavescentis powder, radix astragali powder, herba plantaginis powder, rhizoma Atractylodis powder, herba Taraxaci powder, herba Portulacae powder, flos Caryophylli powder and fructus forsythiae powder in sterilized and dried containers respectively;
(5) according to the weight portion ratio, each part of the skin mucosa disinfectant is prepared according to the following weight portion ratio: 1-3 mg of honeysuckle, 1-2 mg of liquorice, 2-3 mg of sophora flavescens, 2-3 mg of plantain, 1-3 mg of dandelion, 2-3 mg of masson weed, 1-3 mg of astragalus membranaceus, 2-3 mg of clove, 1-3 mg of rhizoma atractylodis and 1-3 mg of fructus forsythiae, placing all the powders in a container, uniformly mixing, adding ethanol liquid with concentration being seventy-five percent, which is twice of the weight of all the powders, uniformly stirring to obtain a pasty mixture, then standing for 12 hours in an open manner to volatilize the ethanol liquid, and filtering by using a plurality of layers of medical gauzes to obtain an extracting solution A;
(6) filtering the mixture obtained in the step (5) by using medical filter paper, filling filter residues obtained by filtering into a sterilized and dried container, adding the menthone extract according to the weight ratio, adding deionized water, and uniformly mixing to obtain a solution B;
(7) adding a double-chain quaternary ammonium salt compound into each part of skin mucosa disinfectant according to the content of 0.1-0.25 mg of didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride in the skin mucosa disinfectant, adding the obtained didecyl dimethyl ammonium bromide or didecyl dimethyl ammonium chloride into filter residues obtained by filtering, heating the filter residues, continuously stirring the filter residues in the heating process, adding deionized water, controlling the heating temperature to be 79-90 ℃, heating for 10min, naturally cooling the filter residues, filtering by using a plurality of layers of medical gauze to obtain a finished product, and bottling the obtained skin mucosa disinfectant in equal weight.
CN202010193256.4A 2020-03-18 2020-03-18 Skin mucosa disinfectant and using method thereof Pending CN111329899A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112675059A (en) * 2021-01-08 2021-04-20 安徽万光生物科技有限公司 Mouthwash containing didecyl dimethyl ammonium chloride and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105580A (en) * 1994-07-23 1995-07-26 王新昌 Indoor cleaning agent capable of removing heat from the heart and restoring consciousness
CN103271985A (en) * 2013-06-14 2013-09-04 柯美华 Disinfectant for skin and mucosa

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1105580A (en) * 1994-07-23 1995-07-26 王新昌 Indoor cleaning agent capable of removing heat from the heart and restoring consciousness
CN103271985A (en) * 2013-06-14 2013-09-04 柯美华 Disinfectant for skin and mucosa

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112675059A (en) * 2021-01-08 2021-04-20 安徽万光生物科技有限公司 Mouthwash containing didecyl dimethyl ammonium chloride and preparation method thereof

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