CN111317770A - Antibacterial liquid - Google Patents
Antibacterial liquid Download PDFInfo
- Publication number
- CN111317770A CN111317770A CN202010302078.4A CN202010302078A CN111317770A CN 111317770 A CN111317770 A CN 111317770A CN 202010302078 A CN202010302078 A CN 202010302078A CN 111317770 A CN111317770 A CN 111317770A
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- China
- Prior art keywords
- aqueous solution
- solution
- wheatgrass
- water
- shell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007788 liquid Substances 0.000 title claims abstract description 32
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 24
- 239000007864 aqueous solution Substances 0.000 claims abstract description 74
- 239000000243 solution Substances 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 241001668545 Pascopyrum Species 0.000 claims abstract description 38
- 230000003385 bacteriostatic effect Effects 0.000 claims abstract description 29
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 24
- 244000178870 Lavandula angustifolia Species 0.000 claims abstract description 20
- 235000010663 Lavandula angustifolia Nutrition 0.000 claims abstract description 20
- 239000001102 lavandula vera Substances 0.000 claims abstract description 20
- 235000018219 lavender Nutrition 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 14
- 239000008213 purified water Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 230000001954 sterilising effect Effects 0.000 claims abstract description 7
- 241001657422 Camellia petelotii Species 0.000 claims abstract description 5
- 230000007062 hydrolysis Effects 0.000 claims abstract description 4
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
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- 238000001914 filtration Methods 0.000 claims description 8
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- 239000004332 silver Substances 0.000 claims description 6
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- 238000001816 cooling Methods 0.000 claims description 5
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- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
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- 102000004169 proteins and genes Human genes 0.000 claims description 4
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 238000009631 Broth culture Methods 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- 230000036782 biological activation Effects 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
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- KYWIYKKSMDLRDC-UHFFFAOYSA-N undecan-2-one Chemical compound CCCCCCCCCC(C)=O KYWIYKKSMDLRDC-UHFFFAOYSA-N 0.000 description 2
- XLYLQUQHYUOPIW-UHFFFAOYSA-N 3-oxo-Tetradecanal Chemical compound CCCCCCCCCCCC(=O)CC=O XLYLQUQHYUOPIW-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoylacetaldehyde Natural products CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
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- 238000012404 In vitro experiment Methods 0.000 description 1
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- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 241000237510 Placopecten magellanicus Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
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- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
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- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
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- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 229940083980 lavender extract Drugs 0.000 description 1
- 235000020723 lavender extract Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 239000011733 molybdenum Substances 0.000 description 1
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- 229960003080 taurine Drugs 0.000 description 1
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 1
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- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bacteriostatic liquid which is prepared from the following raw materials (by volume ratio), 5-25 ml of shell hydrolysis liquid, 500 ml of lavender aqueous solution, 10-100 ml of camellia chrysantha aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution, and 4685 ml of purified water 3675-. The extraction liquid of natural plants such as lavender, golden camellia, wheatgrass and the like is adopted, the extraction time is shortened and the energy consumption is reduced through an ultrasonic process, and meanwhile, the ultrasonic wave has a certain sterilization effect and can ensure that the extraction liquid is not easy to deteriorate. The invention has the beneficial effects that: in the raw materials and the preparation process, the natural environment-friendly concept is realized, the implementation is easy, and the effect is obvious.
Description
Technical Field
The invention relates to a bacteriostatic liquid, and belongs to the technical field of biological products.
Background
At present, a plurality of antibacterial products are adopted, and the materials and the drug effects are different. Most of the existing bacteriostatic products contain chemical components which can really play the roles of antibiosis and sterilization, but have side effects on human bodies more or less after long-term use and influence on the environment. The bacteriostatic product aiming at the surface of human skin needs to solve the stimulation influence on the skin.
Disclosure of Invention
The invention aims to provide a hydrophilic plant macromolecular bacteriostatic and antiviral solution for human skin, which has the characteristics of environmental protection, safety and the like.
In order to achieve the purpose, the technical scheme of the invention is as follows: the bacteriostatic solution is prepared from the following raw materials in volume ratio, 5-25 ml of hydrolyzed shell solution, 500 ml of lavender aqueous solution, 10-100 ml of camellia chrysantha aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution, and 4685 ml of purified water 3675-.
A preparation method of antibacterial liquid comprises: firstly, 5-25 ml of shell hydrolysis liquid, 500 ml of lavender aqueous solution, 10-100 ml of camellia chrysantha aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution and 4685 ml of purified water are added into a container of an ultrasonic generator; then mixing and heating to 20-28 ℃; then shaking at 60kHz frequency for 10-15 minutes, standing for 30 minutes, and taking out supernatant to obtain the antibacterial liquid.
The hydrolyzed shell liquid is aqueous solution which is extracted from sea water shell aqueous solution and is rich in keratin (amino acid), taurine and calcium carbonate existing in the form of polypeptide.
Preparing a shell water solution by an enzymolysis method: firstly, grinding seashells cultured in seawater into fine powder of 200 meshes, adding distilled water, and stirring to prepare an aqueous solution containing 50-60% (g/v) of the shell powder; then heating the shell powder water solution, maintaining the temperature at 45-55 ℃, adding neutral protease which is 1 per mill of the weight of the shell powder and has the activity of 40000-50000u/G, continuously stirring for 4-5 hours, and filtering out solids to obtain the shell water solution after enzymolysis; then placing the shell water solution after enzymolysis into a distillation dish, heating to 100 ℃ for 5-10 minutes, sterilizing and inactivating enzyme; finally collecting the distillate to obtain the colloidal protein with the effective components of polypeptide form and calcium carbonate dissolved in the water solution.
The lavender aqueous solution is an aqueous solution containing 10% lavender essential oil.
The camellia nitidissima aqueous solution is an aqueous solution containing 1% camellia nitidissima concentrated solution.
The water solution of the wheatgrass is white antibacterial water solution extracted from the wheatgrass. The preparation method of the wheatgrass water solution comprises the following steps: firstly, taking dry wheatgrass, and mixing the dry wheatgrass with the water according to the volume ratio of 1: 5-10, adding purified water; then putting the mixture into a pressure cooker to be boiled for 10 to 15 minutes to obtain yellow aqueous solution; distilling the yellow aqueous solution after the solid is removed by filtering to obtain a distilled aqueous solution, and standing and cooling; the cooled distillate is layered, the upper layer is white, and the lower layer is yellow; and finally, absorbing the upper white aqueous solution to obtain the required wheatgrass aqueous solution. The wheatgrass has antibacterial effect and can be used for treating skin eczema.
The colloidal silver or silver ion solution is a water solution containing 10-100PPM of silver.
The crystal sugar is prepared from a colloidal silver or silver ion solution, a shell hydrolysis solution, a lavender aqueous solution, a golden camellia aqueous solution and a comfrey aqueous solution, and has a treatment effect on skin eczema besides the known antibacterial effect of silver. The sea cowry extract has excellent skin care effect, and the board of clothes has good function of repairing damaged skin. The Camellia Chysantha has good antioxidation, and the shellfish enzymolysis liquid has good water retention effect. The lavender liquid and the golden camellia liquid can also improve the fishy smell of the sea scallop enzymatic hydrolysate. In the above raw materials, wherein:
the shell powder has the natural characteristic of environmental protection. The shell powder fine particles (calcium carbonate) treated by the biological activation technology are in a porous fibrous double-helix structure, so that the dispersion protection of colloidal silver or silver ions is facilitated, the long-acting sterilization capability of the colloidal silver is maintained, and the skin surface is kept moist. The shell powder film treated by the biological activation technology has very strong antibacterial and bactericidal effects on escherichia coli, and has obvious effects on salmonella and yellow glucose bacteria.
The lavender aqueous solution can clean skin, control oil content, remove freckles, whiten skin, remove wrinkles, tender skin, promote regeneration and recovery of damaged tissues and the like. The lavender essential oil can balance the oil secretion on the surface layer of the skin, relieve the sensitive skin, astringe pores and supplement the moisture of the skin. The lavender extract mainly contains antibacterial components of lavender essence, namely decanoyl acetaldehyde, methyl n-nonyl ketone, myrcene and the like, and a small amount of aromatic oil, has strong antiviral effect, and can promote capillary vessel dilation, increase blood flow, promote cell growth and prevent scars.
The Camellia Chysantha is rich in Camellia Chysantha polyphenol, and has antibacterial and antiviral effects. The camellia nitidissima belongs to a nontoxic grade, contains more than 400 nutrient substances and has no toxic or side effect. Is rich in various natural nutrients such as tea polysaccharide, tea polyphenol, total saponin, total flavone, tea pigment, caffeine, protein, vitamin B1, vitamin B2, vitamin C, vitamin E, folic acid, fatty acid, B-carotene and the like; the golden camellia contains dozens of amino acids such as theanine and threonine, is rich in various natural trace elements such as organic germanium (Ge), selenium (Se), molybdenum (Mo), zinc (Zn) and vanadium (V) which have important health care effects on human bodies, and is rich in macroelements such as potassium (K), calcium (Ca) and magnesium (Mg).
The wheatgrass has antiviral effect, and crystal sugar oxalic acid B contained in the wheatgrass can inhibit virus proliferation and interfere early growth of the virus as proved by in vitro experiments. Experiments prove that the early infection process of the simple herpes simplex virus can be influenced.
The silver ion has very good bactericidal and anti-inflammatory effects, has the widest antibacterial spectrum, has a bactericidal effect on bacterial fungi and kills drug-resistant bacteria. There are colloidal silver aqueous solutions on the market. High-purity colloidal silver or electrolytic silver ions produced by an electric explosion method are selected and purchased.
The invention adopts the extract of natural plants such as lavender, golden camellia, wheatgrass and the like, shortens the preparation time and reduces the energy consumption by an ultrasonic process, and meanwhile, the ultrasonic wave has a certain sterilization function and can ensure that the extract is not easy to deteriorate. In the raw materials and the preparation process, the natural environment-friendly concept is realized, and the method has the advantages of simple process, easy implementation and obvious effect.
In order to verify the bacteriostatic effect of the invention, the following bacteriostatic experiments are carried out, and the bacteriostatic effect experiment method of the invention comprises the following steps:
1. respectively diluting bacteriostatic solutions A and B by using sterile physiological saline/distilled water by using a test tube double dilution method according to the following dilution ratio:
the bacteriostatic liquid A is a stock solution; 1: 2; 1: 4; 1: 8; 1: 16; 1:32, 1: 64; 1:128
B, bacteriostatic liquid B: stock solution; 1: 2; 1: 4; 1: 8; 1: 16; 1:32, 1: 64; 1:128
2. Experimental procedure
2.1, sequentially adding 100 ul of each prepared doubly diluted 8 concentration gradient bacteriostatic solution into No. 1-8 holes of each row of a 96-well plate by using a pipette gun (total 160 holes), filling 100 ul of M-H broth culture medium into the remaining 5 holes of each row, and selecting 3 holes to add corresponding positive control drugs (the drug concentration refers to the clinical routine dosage).
2.2 dropping the prepared suspension of the drug-resistant strain into 8 holes (100 μ l per hole) in the same row with the serial number of the suspension by using a pipette, and taking the suspension without adding the suspension in the next hole of each row as a blank control.
And 2.3, covering the cover plate, incubating for 24h in an incubator at 35 ℃, observing the growth condition of bacteria in the small holes, and determining the minimum bacteriostatic solution concentration for completely inhibiting the growth of the bacteria as the MIC of the bacteriostatic solution to the drug-resistant bacteria.
Each set of experiments was run in triplicate.
The experimental method is repeated aiming at common escherichia coli, salmonella, yellow glucose bacteria and the like, and the bacteriostatic effect after the bacteria are added is observed.
Experiments show that the invention has good inhibition effect on common strains.
In order to explain the present invention in detail, the present invention will be further described with reference to examples.
Detailed Description
Example 1
A bacteriostatic liquid is prepared from (by volume ratio) hydrolyzed shell liquid 5 ml, lavender aqueous solution 100 ml, golden camellia aqueous solution 10 ml, wheatgrass aqueous solution 100 ml, colloidal silver solution 100 ml, and purified water 4685 ml.
A preparation method of antibacterial liquid comprises: firstly, adding 5 ml of shell hydrolysate liquid, 100 ml of lavender aqueous solution, 10 ml of golden camellia aqueous solution, 100 ml of wheatgrass aqueous solution, 100 ml of colloidal silver or silver ion solution and 4685 ml of purified water into a container of an ultrasonic generator; then mixing and heating to 20-28 ℃; then shaking at 60kHz frequency for 10-15 minutes, standing for 30 minutes, and taking out supernatant to obtain the antibacterial liquid.
The preparation method of the shell water solution comprises the following steps: firstly, cleaning sea water shells, grinding the sea water shells into fine powder of 200 meshes, adding distilled water, and stirring to prepare an aqueous solution containing 50-60% (g/v) of shell powder; then heating the shell powder water solution, maintaining the temperature at 45-55 ℃, adding neutral protease which is 1 per mill of the weight of the shell powder and has the activity of 40000-50000u/G, continuously stirring for 4-5 hours, and filtering out solids to obtain the shell water solution after enzymolysis; then placing the shell water solution after enzymolysis into a distillation dish, heating to 100 ℃ for 5-10 minutes, sterilizing and inactivating enzyme; finally, the distillate is collected, and the effective components of the distillate are colloidal protein (amino acid) in a polypeptide form and calcium carbonate dissolved in an aqueous solution.
The lavender aqueous solution is an aqueous solution containing 10% of lavender essential oil, and is sold in the market.
The Camellia nitidissima aqueous solution is an aqueous solution containing 1% Camellia nitidissima concentrated solution. The golden camellia concentrated solution is sold by golden camellia industry group limited company of Guirentang in Guangxi Fengchong City and biological science and technology limited company of Guangxi Beihai jin.
The water solution of the wheatgrass is white antibacterial water solution extracted from the wheatgrass, and the preparation method of the water solution of the wheatgrass comprises the following steps: firstly, taking dry wheatgrass, and mixing the dry wheatgrass with the water according to the volume ratio of 1: 5, adding purified water; then putting the mixture into a pressure cooker to be boiled for 10 minutes to obtain yellow aqueous solution; distilling the yellow aqueous solution after the solid is removed by filtering to obtain a distilled aqueous solution, and standing and cooling; the cooled distillate is layered, the upper layer is white, and the lower layer is yellow; and finally, absorbing the upper white aqueous solution to obtain the required wheatgrass aqueous solution.
The colloidal silver or silver ion solution is an aqueous solution containing 100PPM of colloidal silver, and is sold in the market.
The invention prepared by the raw materials and the preparation method is used for carrying out an antibacterial effect experiment, and the method comprises the following steps:
1. respectively diluting bacteriostatic solutions A and B by using sterile physiological saline/distilled water by using a test tube double dilution method according to the following dilution ratio:
the bacteriostatic liquid A is a stock solution; 1: 2; 1: 4; 1: 8; 1: 16; 1:32, 1: 64; 1:128
B, bacteriostatic liquid B: stock solution; 1: 2; 1: 4; 1: 8; 1: 16; 1:32, 1: 64; 1:128
2. Experimental procedure
2.1, sequentially adding 100 ul of each prepared doubly diluted 8 concentration gradient bacteriostatic solution into No. 1-8 holes of each row of a 96-well plate by using a pipette gun (total 160 holes), filling 100 ul of M-H broth culture medium into the remaining 5 holes of each row, and selecting 3 holes to add corresponding positive control drugs (the drug concentration refers to the clinical routine dosage).
2.2 dropping the prepared suspension of the drug-resistant strain into 8 holes (100 μ l per hole) in the same row with the serial number of the suspension by using a pipette, and taking the suspension without adding the suspension in the next hole of each row as a blank control.
And 2.3, covering the cover plate, incubating for 24h in an incubator at 35 ℃, observing the growth condition of bacteria in the small holes, and determining the minimum bacteriostatic solution concentration for completely inhibiting the growth of the bacteria as the MIC of the bacteriostatic solution to the drug-resistant bacteria.
Each set of experiments was run in triplicate.
The experimental method is repeated aiming at common escherichia coli, salmonella, yellow glucose bacteria and the like, and the bacteriostatic effect after the bacteria are added is observed.
Through experiments, the diluted antibacterial solution has a good inhibition effect on common strains.
Example 2
An antibacterial liquid is prepared from 25 ml of shell hydrolysate, 500 ml of lavender aqueous solution, 100 ml of golden camellia aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution and 3675 ml of purified water according to volume ratio.
The preparation method of the wheatgrass water solution comprises the following steps: firstly, taking dry wheatgrass, and mixing the dry wheatgrass with the water according to the volume ratio of 1: 10, adding purified water; then putting the mixture into a pressure cooker to be boiled for 10 minutes to obtain yellow aqueous solution; distilling the yellow aqueous solution after the solid is removed by filtering to obtain a distilled aqueous solution, and standing and cooling; the cooled distillate is layered, the upper layer is white, and the lower layer is yellow; and finally, absorbing the upper white aqueous solution to obtain the required wheatgrass aqueous solution.
The colloidal silver solution is an aqueous solution containing 10PPM of colloidal silver.
The rest is the same as example 1.
Example 3
An antibacterial liquid is prepared from 250 ml of colloidal silver ion solution, 7.5 ml of shell hydrolysate solution, 500 ml of lavender aqueous solution, 50 ml of golden camellia aqueous solution, 150 ml of wheatgrass aqueous solution and 4042.5 ml of purified water according to volume ratio.
The colloidal silver or silver ion solution is an aqueous solution containing 100PPM of silver.
The preparation method of the wheatgrass water solution comprises the following steps: firstly, taking dry wheatgrass, and mixing the dry wheatgrass with the water according to the volume ratio of 1: 7.5, adding purified water; then putting the mixture into a pressure cooker to be boiled for 15 minutes to obtain yellow aqueous solution; distilling the yellow aqueous solution after the solid is removed by filtering to obtain a distilled aqueous solution, and standing and cooling; the cooled distillate is layered, the upper layer is white, and the lower layer is yellow; and finally, absorbing the upper white aqueous solution to obtain the required wheatgrass aqueous solution.
The rest is the same as example 1.
Claims (5)
1. The bacteriostatic solution is prepared from the following raw materials in volume ratio, 5-25 ml of hydrolyzed shell solution, 500 ml of lavender aqueous solution, 10-100 ml of camellia chrysantha aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution, and 4685 ml of purified water 3675-.
2. The bacteriostatic liquid according to claim 1, wherein: a preparation method of antibacterial liquid comprises: firstly, 5-25 ml of shell hydrolysis liquid, 500 ml of lavender aqueous solution, 10-100 ml of camellia chrysantha aqueous solution, 200 ml of wheatgrass aqueous solution, 500 ml of colloidal silver or silver ion solution and 4685 ml of purified water are added into a container of an ultrasonic generator; then mixing and heating to 20-28 ℃; then shaking at 60kHz frequency for 10-15 minutes, standing for 30 minutes, and taking out supernatant to obtain the antibacterial liquid.
3. The bacteriostatic liquid according to claim 1, wherein: grinding seashells cultured in seawater into fine powder of 200 meshes, adding distilled water, and stirring to obtain an aqueous solution containing 50-60% (g/v) of the shell powder; then heating the shell powder water solution, maintaining the temperature at 45-55 ℃, adding neutral protease which is 1 per mill of the weight of the shell powder and has the activity of 40000-50000u/G, continuously stirring for 4-5 hours, and filtering out solids to obtain the shell water solution after enzymolysis; then placing the shell water solution after enzymolysis into a distillation dish, heating to 100 ℃ for 5-10 minutes, sterilizing and inactivating enzyme; finally collecting the distillate to obtain the colloidal protein with the effective components of polypeptide form and calcium carbonate dissolved in the water solution.
4. The bacteriostatic liquid according to claim 1, wherein: the preparation method of the water solution of the wheatgrass comprises the following steps: firstly, taking dry wheatgrass, and mixing the dry wheatgrass with the water according to the volume ratio of 1: 5-10, adding purified water; then putting the mixture into a pressure cooker to be boiled for 10 to 15 minutes to obtain yellow aqueous solution; distilling the yellow aqueous solution after the solid is removed by filtering to obtain a distilled aqueous solution, and standing and cooling; the cooled distillate is layered, the upper layer is white, and the lower layer is yellow; and finally, absorbing the upper white aqueous solution to obtain the required wheatgrass aqueous solution.
5. The bacteriostatic liquid according to claim 1, wherein: the concentration of the colloidal silver or silver ions is 10-100 ppm.
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