CN105535014A - Skin and hand disinfectant - Google Patents

Abstract

The invention discloses a skin and hand disinfectant. The skin and hand disinfectant solves the problem that the existing skin and hand disinfectant product causes skin irritation and cross infection. The skin and hand disinfectant is prepared from 0.1-0.2wt% of polyhexamethylene biguanidine, 45-55wt% of ethanol, 0.03-0.08wt% of an emollient, 0.008-0.012wt% of a flavoring agent and 45-55wt% of purified water. The skin and hand disinfectant has the advantages of scientific formula, simple preparation processes, low cost and environmental friendliness and has a very wide market prospect.

Description

Skin hand disinfectant

Technical field

The invention belongs to biological and new medical technology field, relate in particular to a kind of skin hand-wrist bones compound preparation.

Background technology

In the past, it is fancy soap, soap that people wash one's hands usual.Although they are also to reach certain cleaning performance, have certain stimulation to skin, alkalescence is too large, and degreasing power is too strong, and clean effect is also not satisfactory.More seriously, life-time service, can cause pachylosis, is chapped from the cold, peels.

Raising along with the life class of people and the higher understanding to U.S. and requirement, only the soap of cleaning action no longer can meet this two-way demand of people, now, handwashing liquid meets the tendency, with traditional fancy soap, soap is compared, the handwashing liquid tool advantage of her uniqueness:

The first, the solids such as soap, fancy soap becomes easily infected by dirt on hand and the bacterium that disappears, and becomes secondary pollution source.And the pump head of the contact surface of handwashing liquid and hands generally just on bottle, and easy to clean, avoid cross infection probability.

The second, the diversification of hand cleanser products composition, the composition of handwashing liquid generally all contains the natural plant compositions such as pure glycerin, Aloe, Oleum Hippophae vitamin C, and adopts high-tech MNSH formula, and pH value is moderate, reaches the requirement of green product.The product property of handwashing liquid belongs to neutral, without phosphorus, aluminum, alkali, sodium alkyl benzene sulfonate etc., gentle decontamination, easily accepted by skin, the Aloe particularly wherein contained, the compositions such as Oleum Hippophae vitamin C, more can play to the skin of hand the effect moistened deeply, although some fancy soaps also have have certain function of moistening to hand, their effect has difficulties in competiting with handwashing liquid.

3rd, sterilizing effect is obvious.Handwashing liquid is to Candida albicans, and staphylococcus aureus, escherichia coli, hepatitis A, the sterilization rate of the source of disease such as hepatitis B can reach more than 90%, to human body nonirritant, and without anaphylaxis.Effectively protect household with oneself away from antibacterial and disease.

4th, practicality is stronger.Handwashing liquid is by hand taken amount, and only need gently press pump head, liquid just flows into the palm of the hand, how much is grasped by oneself, conveniently easily gets, also easily save.And handwashing liquid foaming abundancy is fine and smooth, and namely water feel well excessively, can save time again by water-saving.

Summary of the invention

The object of the invention is to coordinate science for market provides a kind of, produce the skin hand disinfectant with high-effective disinfecting, disposable, skin protection of simple, with low cost, safety and environmental protection.

Technical scheme of the present invention is: it is that poly hexamethylene biguanide, ethanol, emollient, flavouring agent etc. and pure water are carried out composite forming, and each raw materials by weight calculates:

Poly hexamethylene biguanide: 0.1 ~ 0.2%, ethanol: 45 ~ 55%, emollient: 0.03 ~ 0.08%, flavouring agent: 0.008 ~ 0.012%, pure water: 45 ~ 55%.

Its manufacture method is as follows:

A. in the stainless steel cauldron of 1500L by said ratio, ethanol is slowly added in deionized water, opens reactor and stir, with the stir speed (S.S.) batch mixing 1 hour of 90 revs/min;

B. add in the ethanol water configured at reactor and take quantitative poly hexamethylene biguanide, stirring at normal temperature 2 hours, after the abundant mix homogeneously of poly hexamethylene biguanide, add adjuvant emollient, the flavouring agent of corresponding proportion, stirring at normal temperature 3 hours;

C. last citric acid or sodium citrate regulate pH=4.8 ± 1.0;

D. fully stir half an hour, then carry out filtering, canned, be packaged into finished product;

E. put in storage after the assay was approved.

The mechanism of action of the present invention is:

Due to environment-friendly type macromolecule polymer disinfection sanitizer---the polyhexamethylene guanidine used, there is broad-spectrum, valid density is low, speed of action is fast, stable in properties, premium properties soluble in water; Can use at normal temperatures; For a long time antibacterial, have no side effect; Non-corrosiveness; Colourless, odorless, nontoxic; Do not fire, not quick-fried, use safety; Moderate, convenient transportation, can be described as best antibacterial.

Result of study displays a large amount of both at home and abroad, poly hexamethylene biguanide has nontoxic, the feature that the antibacterial time is long.Toxicology test shows that PHMB chmice acute Oral toxicity is tested, and LD50 > 5000mg/kg body weight, according to acute toxicity grading criteria, belongs to actual non-toxic type.After rabbit Skin Irritation Test rabbit skin once contacts poly hexamethylene biguanide, stimulate integrated value to be 0, belong to nonirritant; After rabbit eye irritant test, rabbit eyes mucosa (cornea, iris, conjunctiva) irritant reaction integration is 0, belongs to nonirritant; After guinea pig skin sensitization test (STT), 24h, 48h guinea pig skin pilot region is showed no obvious erythema and edema appearance, and sample sensitization rate is 0, by the classification of sensitization intensity, belongs to weak sensitizer (I level).Therefore, poly hexamethylene biguanide is considered to the disinfectant of at present most safety non-toxic.

The bactericidal effect of poly hexamethylene biguanide is: 0.02% polyhexamethylene guanidine is 100% to escherichia coli sterilizing rate; 0.02% polyhexamethylene guanidine is 100% to staphylococcus aureus sterilizing rate; 0.02% polyhexamethylene guanidine is 100% to Candida albicans sterilizing rate; 0.05% polyhexamethylene guanidine is 100% to gonococcal bactericidal rate.On-the-spot bactericidal assay is 99.8% to body surface sterilizing rate, is greater than the disinfection indicator of national regulation 90%.On-the-spot bactericidal assay is 97.65% to palm surface disinfection rate, is greater than the disinfection indicator of national regulation 90%.Lot of experiments shows, poly hexamethylene biguanide can kill bafta bacterial catalase and fungus, acanthamoeba keratitis pathogen, escherichia coli of going out, staphylococcus aureus and Candida albicans, skin natural bacteria, inactivation of viruses, bacterial spore, bacterial propagule etc. under extremely low concentration (10ppm), and the bactericidal effect of polyhexamethylene guanidine is less by the impact of ambient temperature, pH and Organic substance etc.

Beneficial effect of the present invention is: owing to being be that the hands of high-efficiency low-toxicity that main component is produced disappears product with poly hexamethylene biguanide, and the advantage such as fragrant when having high-effective disinfecting, disposable, skin protection, a use, 50% ethanol compatibility improves the disinfection time.And the emollient selected has very strong skin protection, skin moistening effect, do not affect Disinfection Effect simultaneously.

Accompanying drawing explanation

Fig. 1 is production process route schematic diagram of the present invention.

Detailed description of the invention

As shown in Figure 1, skin hand disinfectant is that poly hexamethylene biguanide, ethanol, emollient, flavouring agent and pure water are carried out composite forming, and each raw materials by weight calculates:

Poly hexamethylene biguanide: 0.1 ~ 0.2%,

Ethanol: 45 ~ 55%,

Emollient: 0.03 ~ 0.08%,

Flavouring agent: 0.008 ~ 0.012%,

Pure water: 45 ~ 55%.

Embodiment 1:

Various raw materials by weight is: poly hexamethylene biguanide 0.15%, ethanol 50%, emollient 0.05%, flavouring agent 0.01%, pure water 50%.

Its manufacture method is as follows:

A. in the stainless steel cauldron of 1500L, add 600 kilograms of deionized waters, then 600 kg ethanol are slowly added in deionized water, open reactor and stir, with the stir speed (S.S.) batch mixing 1 hour of 90 revs/min;

B. the 1.8 kilograms of poly hexamethylene biguanides taken are added in the ethanol water configured at reactor, stirring at normal temperature 2 hours, after the abundant mix homogeneously of poly hexamethylene biguanide, add 0.6 kilogram of emollient and 0.12 kilogram of flavouring agent that corresponding proportion takes, stirring at normal temperature 3 hours;

C. last citric acid or sodium citrate regulate pH=4.8 ± 1.0;

D. fully stir half an hour, then carry out filtering, canned, be packaged into finished product;

E. put in storage after the assay was approved.

Embodiment 2:

Various raw materials by weight is: poly hexamethylene biguanide 0.1%, ethanol 45%, emollient 0.04%, flavouring agent 0.009%, pure water 55%.

A. in the stainless steel cauldron of 1500L, add 660 kilograms of deionized waters, then 540 kg ethanol are slowly added in deionized water, open reactor and stir, with the stir speed (S.S.) batch mixing 1 hour of 90 revs/min;

B. the 1.2 kilograms of poly hexamethylene biguanides taken are added in the ethanol water configured at reactor, stirring at normal temperature 2 hours, after the abundant mix homogeneously of poly hexamethylene biguanide, add 0.48 kilogram of emollient and 0.11 kilogram of flavouring agent that corresponding proportion takes, stirring at normal temperature 3 hours;

C. last citric acid or sodium citrate regulate pH=4.8 ± 1.0;

D. fully stir half an hour, then carry out filtering, canned, be packaged into finished product;

E. put in storage after the assay was approved.

Embodiment 3:

Various raw materials by weight is: poly hexamethylene biguanide 0.2%, ethanol 55%, emollient 0.07%, flavouring agent 0.011%, pure water 45%.

A. in the stainless steel cauldron of 1500L, add 540 kilograms of deionized waters, then 660 kg ethanol are slowly added in deionized water, open reactor and stir, with the stir speed (S.S.) batch mixing 1 hour of 90 revs/min;

B. the 2.4 kilograms of poly hexamethylene biguanides taken are added in the ethanol water configured at reactor, stirring at normal temperature 2 hours, after the abundant mix homogeneously of poly hexamethylene biguanide, add 0.84 kilogram of emollient and 0.13 kilogram of flavouring agent that corresponding proportion takes, stirring at normal temperature 3 hours;

C. last citric acid or sodium citrate regulate pH=4.8 ± 1.0;

D. fully stir half an hour, then carry out filtering, canned, be packaged into finished product;

E. put in storage after the assay was approved.

Claims (1)

1. a skin hand disinfectant, is characterized in that: it is that poly hexamethylene biguanide, ethanol, emollient, flavouring agent and pure water are carried out composite forming, and each raw materials by weight calculates:

Poly hexamethylene biguanide: 0.1 ~ 0.2%,

Ethanol: 45 ~ 55%,

Emollient: 0.03 ~ 0.08%,

Flavouring agent: 0.008 ~ 0.012%,

Pure water: 45 ~ 55%;

Its manufacture method is as follows:

A. in the stainless steel cauldron of 1500L by said ratio, ethanol is slowly added in deionized water, opens reactor and stir, with the stir speed (S.S.) batch mixing 1 hour of 90 revs/min;

B. add in the ethanol water configured at reactor and take quantitative poly hexamethylene biguanide, stirring at normal temperature 2 hours, after the abundant mix homogeneously of poly hexamethylene biguanide, add adjuvant emollient, the flavouring agent of corresponding proportion, stirring at normal temperature 3 hours;

C. last citric acid or sodium citrate regulate pH=4.8 ± 1.0;

D. fully stir half an hour, then carry out filtering, canned, be packaged into finished product;

E. put in storage after the assay was approved.