CN102265893B - Antimicrobial composite and application thereof - Google Patents
Antimicrobial composite and application thereof Download PDFInfo
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- CN102265893B CN102265893B CN201110151285.5A CN201110151285A CN102265893B CN 102265893 B CN102265893 B CN 102265893B CN 201110151285 A CN201110151285 A CN 201110151285A CN 102265893 B CN102265893 B CN 102265893B
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Abstract
The purpose of the invention is to provide an antimicrobial composite with a simple formula and low cost, and on the premise of ensuring a sterilization effect, low dose of sterilization active ingredient is used in the antimicrobial composite; another purpose of the invention is to provide a new application of a chemical composite in preparation of antimicrobial products; and the invention discloses an application of a chemical composite containing ethanol, polyethylene hexamethylene biguanide (PHMB) or salts thereof and isopropanol in preparation of antimicrobial products, wherein the sum of ethanol and isopropanol (by weight percent) is not more than 60%.
Description
Technical field
The present invention relates to a kind of antimicrobial Chemical composition that and the application of said composition in preparation antimicrobial products.
Background technology
Due to increasing the weight of of global warming and environmental pollution, the variation of pathogenic microorganisms is accelerated; The abuse of various antibiotic, antiviral drugs; to the virus of antibiotic and the immunity of enantiopathy cytotoxic drug; and the generation of the pathogenic microorganisms of highly pathogenic highly infective is also in quickening; reply and control caused by pathogenic microorganisms infectious disease break out with popular; just must control source of infection, cut off route of transmission and protection susceptible person; wherein, cutting off route of transmission is safe and reliable important means.
Methylguanidine in poly hexamethylene biguanide (PHMB) compound has very high activity, easily by bacterium, virus adsorb, directly act on microorganism, inhibit the division copy function of bacterium, virus, it plugs the respiration channel of microorganism in the formation of microorganism body surface polymer, and microorganism is choked to death.Meanwhile, its high molecular polymer structure makes the effective active of guanidine radicals be improved, and bacterium not easily produces drug resistance.
This compound, in the systematic Study of European medicine industry by the research of the research of the studies on acute toxicity of system, human body toxicological study, Study on Subchronic, chronic toxicity and carcinogenic possibility, genotoxicity, reviviscence toxicity research and metabolism, finally draws hexamethylene systematic toxicology conclusion: 1. low acute toxicity; 2. when when normal using dosage, there is low skin and eye irritation; 3. low long-term toxicity; 4. without genotoxicity; 5. non-teratogenesis; 6. proved without reviviscence toxicity by the research between two generations; 7. for the mankind, non-carcinogenic potential drug is belonged to.
The bactericidal mechanism of ethanol, isopropyl alcohol, mainly by the lipid in removing Knowledge On Bacterial Biofilm, makes microorganism protein denaturation solidify and plays sterilization or bacteriostasis, be widely used in sterilization field.
Above-mentioned composition is good fit, plays synergy, can produce better bactericidal activity.
At present, Chinese patent literature has disclosed many antimicrobial products, and wherein part has selected alcohols, polymerization guanidine class etc. to be bactericidal active ingredient.
Application number is the patent application document of 200910114010.7, disclose a kind of by polyhexamethylene hydrochloric acid biguanides and ethanol be major antibacterial active ingredient, polyoxyethylene nonylphenol ether is the skin degerming product of surfactant; Application number is the Chinese patent application file of 200980108019.5, disclose a kind of alcohol antimicrobial skin sanitizing compositions comprising cationic compatible thickeners, it comprises alcohol, thickened systems, cationic compound (as poly hexamethylene biguanide) etc. for skin conditioning benefits at least about 60%; Application number is the Chinese patent application file of 03139745.x, discloses a kind of sterile products be made up of 95% ethanol, poly hexamethylene biguanide, flavouring agent, water surplus; Application number is the Chinese patent application file of 200680032102.5, discloses a kind of by poly hexamethylene biguanide, secondary antimicrobial, and optional organic acid, process auxiliary agent is as the antimicrobial compositions of alcohol and surfactant composition; Application number is the Chinese patent application file of 200910114009.4, disclose a kind of formula of liquid disinfectant, with PHMB (also known as poly hexamethylene biguanide) for principle active component, select polyoxyethylene nonylphenol ether to be surfactant, add essence and make.
At present still not using ethanol, poly hexamethylene biguanide or its salt, isopropyl alcohol three composition as the antimicrobial products of bactericidal active ingredient, or total alcohol amount is apparently higher than the present invention.
Foregoing invention, or containing a large amount of alcohols material, for a long time for the sterilization of hand, skin, may cause the dry lack of water of skin, rubescent, chap, and to the transport of sterile products, store and propose higher requirement; Or compared with the present composition containing same concentrations active ingredient, bactericidal effect is general, needs the long period just can reach or cannot reach the anti-microbe ability with present composition equivalence at all; Or formula components is on the high side, preparation process is loaded down with trivial details, complex process.
Summary of the invention
The object of the invention is to the above-mentioned deficiency overcoming prior art, provide one to have formula simple, the antimicrobial compositions that cost is low; Under the prerequisite ensureing bactericidal effect, the bactericidal active ingredient compared with low dosage can be used; Another object of the present invention is to provide the new opplication of a kind of Chemical composition that in preparation antimicrobial products.
The present invention relates to the application of feedstock composition in preparation antimicrobial products containing poly hexamethylene biguanide (PHMB) or its salt, isopropyl alcohol.
The present invention can also add ethanol;
In composition, the weight ratio sum (i.e. total alcohol amount) of ethanol and isopropyl alcohol is no more than 60%, and preferred total alcohol amount is 10 ~ 59%, and most preferably 25% ~ 58%;
The percentage by weight of poly hexamethylene biguanide or its salt is no more than 25%, is preferably 0.005% ~ 10%, most preferably 0.01% ~ 2%.
This Chemical composition that can be independent or add acceptable auxiliary material, base material, make required antimicrobial products.Its advantage is:
1, raw material is simple, and cost is low;
2, alcohol content is low, solves tradition containing the high problem causing transporting, storage cost significantly increases of alcohol amount total in alcohol sterile products;
3, bactericidal effect is good, has a broad antifungal spectrum;
4, can be used for disposable formula.
With the product that said composition is made, can extensive, safe, practically for killing, suppressing, hinder breeding and the activity of microorganism, preferred combination, can be used for the sterilization of hand, skin, mucous membrane, the occasions such as family, restaurant, hotel, public transport, kindergarten, hospital comprise the sterilization, air sterillization, pet sterilization etc. of food kitchenware at interior general article surface.
Essence for a better understanding of the present invention, will illustrate that by the anti-microbial test result of ethanol, hexamethylene, isopropyl alcohol example combinations it is preparing the new opplication in antimicrobial products below.
One, the Germicidal test of composition of the present invention
1, materials and methods
The active ingredient of 1.1 tests sample (liquid preparation) and content: hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strains:
Escherichia coli (8099)
Staphylococcus aureus (ATCC 6538)
Pseudomonas aeruginosa (ATCC 15442)
Candida albicans (ATCC 10231)
Influenza virus (H
3n
2)
1.3 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
2, result of the test
2.1 pairs of colibacillary sterilize experiment
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of Escherichia coli.(the results are shown in Table 1)
Table 1 is to colibacillary killing effect
。
The sterilize experiment of 2.2 pairs of staphylococcus aureuses
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of staphylococcus aureus.(the results are shown in Table 2)
The killing effect of table 2 pair staphylococcus aureus
。
The sterilize experiment of 2.3 pairs of pseudomonas aeruginosas
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >5.00 of pseudomonas aeruginosa.(the results are shown in Table 3)
The killing effect of table 3 pair pseudomonas aeruginosa
。
The sterilize experiment of 2.4 pairs of Candida albicanss
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, to the average kill oncomelania >4.00 of Candida albicans.(the results are shown in Table 4)
The killing effect of table 4 pair Candida albicans
。
The inactivation test of 2.5 infected by influenzas
Under test temperature is 20 DEG C ± 1 DEG C condition, prove through 3 repeated tests, test sample stoste effect 1.0min, the average kill oncomelania >4.00 of infected by influenza.(the results are shown in Table 5)
The inactivating efficacy of table 5 infected by influenza
。
Note: positive control average log value and scope 4.32(4.23-4.50).
Two, the sterilization field trial of composition of the present invention
1, materials and methods
The active ingredient of 1.1 tests sample (liquid preparation) and content: hexamethylene content 0.3%, ethanol content 44%, isopropyl alcohol 4%.
1.2 test strains: natural bacteria.
1.3 dilutions: the phosphate buffer (PBS) of 0.1% Tween-80, pH value 7.2 ~ 7.4.
1.4 neutralizers: the phosphate buffer (PBS) of 5.0% Tween-80 and 5g/L lecithin.
1.5 test basis:
Respective specified in Ministry of Public Health's " disinfection technology standard ".
1.6 test method
1.6.1 hand-wrist bones field trial
After the mutual rubbing of experimenter's both hands, the five fingers close up, and bedew in containing the test tube of 10ml dilution with sterile cotton swab, come and go wiping 2 times to its left hand the five fingers face of counting on one's fingers from finger tip to finger root, sampling end is cut into former dilution in vitro, as positive controls in sterile working mode.After sampling, get test sample stoste, after skin wiping sterilization 1min, bedew in the test tube containing 10ml neutralizer solution with sterile cotton swab, its right hand same procedure is sampled, as sterilization group.Control group and sterilization group sample liquid are fully beaten and draws 1.0ml with acceptable diluent degree and inoculate plate, in duplicate, tryptose soya agar medium (TSA) is poured into after each group of inoculation plate, together with nonvaccinated test culture medium flat plate after condensation, put in 37 DEG C of incubators and cultivate 48h, counting surviving colonies number, calculates kill oncomelania.
1.6.2 skin degerming field trial
Before sterilization, after the mutual fully rubbing in inner forearm stage casing, experimenter left and right, dimension board is put in section surface in inside experimenter's left forearm, bedew, after drying on tube wall, in the region that dimension board is confined in containing the test tube of 10ml dilution with sterile cotton swab, lateral shuttle embrocates 10 times, longitudinal double rub 3 times, often embrocates one time, cotton swab is rotated one time.Sampling end is cut into former dilution in vitro, as positive controls in sterile working mode.After sampling, get test sample stoste, after skin wiping sterilization 1min, bedew in containing 10ml neutralizer solution test tube with sterile cotton swab, its right forearm same procedure is sampled, as experimental group.Control group and sterilization group sample liquid are fully beaten and draws 1.0ml with acceptable diluent degree and inoculate plate, in duplicate, tryptose soya agar medium (TSA) is poured into after each group of inoculation plate, together with nonvaccinated test culture medium flat plate after condensation, put in 37 DEG C of incubators and cultivate 48h, counting surviving colonies number, calculates kill oncomelania.
2, result of the test
2.1 hand-wrist bones field trials
Through 30 person-times of repeated tests, test sample stoste effect 1min, to the average kill oncomelania >1.00(of the natural bacteria on hand surface in table 6).
Table 6 hand-wrist bones site test results
。
2.2 skin degerming field trials
Through 30 person-times of repeated tests, test sample stoste effect 1min, to the average kill oncomelania >1.00(of the natural bacteria of skin surface in table 7).
Table 7 skin degerming site test results
Embodiment
Further illustrate technical solution of the present invention below in conjunction with specific embodiment, these embodiments can not be interpreted as it is restriction to technical solution.
Embodiment 1
Prepare thimerosal according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol (volume ratio is added successively under stirring, being converted into mass ratio is 92.3%, 440kg, isopropyl alcohol 39kg, glycerine 10kg, hypromellose cellulose solution down together), finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
Wherein, glycerine has the effect of moisturizing skin care, can slow down the stimulation of alcohols solvent to skin, meanwhile, can extend drying time, strengthens antibacterial effect; HPMC can make this thimerosal in skin and article surface film forming, extends the antibacterial time; Bronopol uses used as stabilizers in this product.
In composite formula, the mass percent being equivalent to bactericidal active constituent ethanol is 45.6%; The mass percent of hexamethylene is 0.33%; The mass percent of isopropyl alcohol is 4.3%.
Stability meets the requirement of Ministry of Health of the People's Republic of China's " disinfection technology standard " (version in 2002), the term of validity 24 months.
Through inspection, to chmice acute per os LD
50> 5000 mg/kg body weight, true border is nontoxic; Repeatedly intact skin irritant test total mark mean value is 0, skin irritation index < 0.5, and stimulus intensity belongs to nonirritant; To PCEMNR without causing micronucleus effect; Maximum illeffects dosage of not observing is 1000 mg/kg body weight.
Embodiment 2
The thimerosal prepared, with example 1, is adsorbed in non-woven fabrics as wet tissue annex solution, makes wet sanitary napkins by the preparation method of this sanitizing composition.
After testing, under 20 DEG C ± 1 DEG C condition, wet sanitary napkins effect 1 min, 100% is to colibacillary average kill ratio, 100% is to the average kill ratio of staphylococcus aureus, 100% is to the average kill ratio of pseudomonas aeruginosa, be 99.94% to the average kill ratio of hemolytic streptococcus, be 99.91% to the average kill ratio of Candida albicans, the average kill oncomelania > 3.00 of infected by influenza, to the deactivation logarithm value > 3.00 of HIV virus.
Hand-wrist bones field trial: through 30 person-times of repeated tests, wet sanitary napkins effect 1min, to the average kill oncomelania > 1.00 of the natural bacteria on hand surface.
Escherichia coli Simulation field trial: prove through 30 sampling tests, pollutes colibacillary body surface 1min with wet sanitary napkins wiping, and the Escherichia coli average kill ratio polluted body surface is 100%.
Keep the condition of >=75% in relative moisture under, after placing 14 days (be equivalent to room temperature and place 1 year) in 54 DEG C of insulating boxs, wet sanitary napkins effect 1min is still 100% to colibacillary average kill ratio.
Embodiment 3
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 258kg, isopropyl alcohol 9kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 4
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 13.5 kg, 95% ethanol 414 kg, isopropyl alcohol 27kg, glycerine 5kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 5
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 465kg, isopropyl alcohol 45kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 6
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 22.5 kg, 95% ethanol 440kg, isopropyl alcohol 54kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 7
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 258 kg, isopropyl alcohol 54 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 8
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 15 kg, 95% ethanol 258 kg, isopropyl alcohol 45 kg, glycerine 2kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 9
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 14.5 kg, 95% ethanol 430 kg, isopropyl alcohol 38 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 10
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 14 kg, 95% ethanol 420 kg, isopropyl alcohol 37 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 11
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 15.5 kg, 95% ethanol 450 kg, isopropyl alcohol 40 kg, Sensiva SC50 (a kind of 1-alkyl glycerol ether compound) 10kg, ethohexadiol 3kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 12
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 1kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, the 20% hexamethylene aqueous solution 16 kg, 95% ethanol 460 kg, isopropyl alcohol 41 kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 13
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 3kg, 95% ethanol 463kg, isopropyl alcohol 33kg, glycerine 10kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 14
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 334kg, isopropyl alcohol 51 kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 15
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, 20% hexamethylene aqueous solution 10kg, 95% ethanol 463kg, isopropyl alcohol 33kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 16
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, 20% hexamethylene aqueous solution 15kg, 95% ethanol 484kg, isopropyl alcohol 41kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 17
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, 20% hexamethylene aqueous solution 13.5kg, 95% ethanol 465kg, isopropyl alcohol 27kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 18
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, 20% hexamethylene aqueous solution 16.5kg, 95% ethanol 414kg, isopropyl alcohol 45kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 19
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, 20% hexamethylene aqueous solution 22.5kg, 95% ethanol 258kg, isopropyl alcohol 54kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 20
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, the 20% hexamethylene aqueous solution 14.5 kg, 95% ethanol 450 kg, isopropyl alcohol 38kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 21
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, the 20% hexamethylene aqueous solution 14 kg, 95% ethanol 460 kg, isopropyl alcohol 37 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 22
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, the 20% hexamethylene aqueous solution 15.5 kg, 95% ethanol 430 kg, isopropyl alcohol 40 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 23
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, the 20% hexamethylene aqueous solution 16 kg, 95% ethanol 420 kg, isopropyl alcohol 41 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 24
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.2kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 484kg, isopropyl alcohol 33kg, glycerine 8kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 25
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.9kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.27kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 411kg, isopropyl alcohol 34kg, glycerine 9kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 26
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.33kg, the 20% hexamethylene aqueous solution 50 kg, 95% ethanol 10kg, isopropyl alcohol 1kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet wiping towel annex solution afterwards, make wet wiping towel.
Embodiment 27
According to following steps preparing product: add the hot purified water of 40L in stainless steel cask, be weighed into Hydroxypropyl methylcellulose 0.5kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.33kg, the 20% hexamethylene aqueous solution 100 kg, 95% ethanol 1kg, isopropyl alcohol 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet wiping towel annex solution afterwards, make wet wiping towel.
Embodiment 28
According to following steps preparing product: add 200L purified water in preparing tank, bronopol 0.33kg, 20% hexamethylene aqueous solution 1kg, 95% ethanol 467kg, isopropyl alcohol 54kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet wiping towel annex solution afterwards, make wet wiping towel.
Embodiment 29
Aerosol is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, the 20% hexamethylene aqueous solution 0.5 kg, 95% ethanol 506 kg, isopropyl alcohol 54 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes, be sealed in pressure vessel, refilled a certain amount of propellant.
Embodiment 30
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into C10-30 alkylol acrylamide acid esters cross-linked polymer (one of acrylate copolymer) 2kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 0.1kg, 95% ethanol 506kg, isopropyl alcohol 54kg, glycerine 10 kg, alkylol acrylamide acid esters cross-linked polymer solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 31
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, the 20% hexamethylene aqueous solution 13.5 kg, 95% ethanol 414 kg, isopropyl alcohol 2kg, BSJ15 50 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 32
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 258 kg, isopropyl alcohol 54 kg, PPG-20 methyl ether (a kind of glucosan derivative) 50 kg are added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 33
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 2kg, 95% ethanol 278kg, isopropyl alcohol 20kg, extract solution from aloe 1 kg, glycerine 2 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 34
Wet wiping towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 4kg, 95% ethanol 90kg, isopropyl alcohol 2kg, jojoba oil 2 kg, marine algae extract 1 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.The liquid prepared is adsorbed in non-woven fabrics as wet wiping towel annex solution, makes wet wiping towel.
Embodiment 35
Wet wiping towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 5kg, 95% ethanol 125kg, isopropyl alcohol 5kg, hyaluronic acid 5 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.The liquid prepared is adsorbed in non-woven fabrics as wet wiping towel annex solution, makes wet wiping towel.
Embodiment 36
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 220kg, isopropyl alcohol 100kg, shitosan 10 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 37
Liquid preparation is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 35kg, 95% ethanol 184kg, isopropyl alcohol 12kg, Cer EOS kg, glycerine 2kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 38
Prepare liquid preparation according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.5 kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 304kg, isopropyl alcohol 15kg, SP 5 kg, glycerine 5 kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified rear packing.
The liquid prepared also can be used as wet tissue annex solution and is adsorbed in non-woven fabrics, makes wet tissue.
Embodiment 39
Prepare spray according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into Hydroxypropyl methylcellulose 0.6kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 18kg, 95% ethanol 224kg, isopropyl alcohol 22kg, glycerine 10kg, hypromellose cellulose solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000L scale, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 40
Prepare gel according to following steps: in stainless steel cask, add the hot purified water of 40L, be weighed into polyethylene glycol 190kg and be stirred to transparent clarification.200L purified water is added in preparing tank, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 270kg, isopropyl alcohol 100kg, glycerine 1 kg, essence 0.5 kg, polyglycol solution is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 41
Spray is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 0.25kg, 95% ethanol 101kg, isopropyl alcohol 506kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 42
Wet mop towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 0.5kg, 95% ethanol 11kg, isopropyl alcohol 90kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 43
Wet mop towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 100kg, 95% ethanol 108kg, isopropyl alcohol 150kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 44
Wet mop towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 500kg, 95% ethanol 50kg, isopropyl alcohol 100kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 45
Wet mop towel is prepared: in preparing tank, add 200L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 80kg, isopropyl alcohol 350kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 46
According to following steps preparing product: add 250L purified water, 20% hexamethylene aqueous solution 15kg, 95% ethanol 150kg, isopropyl alcohol 150kg, glycerine 1 kg in stainless steel cask, be weighed into butylation PVP170kg and be stirred to transparent clarification, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 47
According to following steps preparing product: add 20% hexamethylene aqueous solution 8kg, 95% ethanol 400kg, isopropyl alcohol 220kg, glycerine 1 kg in stainless steel cask, be weighed into polyacrylamide methyl propane sulfonic acid 170kg and be stirred to transparent clarification, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 48
Spray is prepared: in preparing tank, add 50L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 10kg, 95% ethanol 97kg, isopropyl alcohol 500kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 49
Spray is prepared: in preparing tank, add 50L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, 95% ethanol 440kg, isopropyl alcohol 39kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 50
Spray is prepared: in preparing tank, add 50L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 12kg, 95% ethanol 460kg, isopropyl alcohol 155kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 51
Spray is prepared: in preparing tank, add 100L purified water according to following steps, bronopol 0.3kg, 20% hexamethylene aqueous solution 9kg, 95% ethanol 120kg, isopropyl alcohol 450kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 52
Spray is prepared: in preparing tank, add 100L purified water according to following steps, bronopol 0.5kg, 20% hexamethylene aqueous solution 13kg, 95% ethanol 380kg, isopropyl alcohol 220kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Embodiment 53
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 7kg, 95% ethanol 270kg, isopropyl alcohol 240kg, glycerine 5kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified rear packing.
Embodiment 54
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.8kg, 20% hexamethylene aqueous solution 6kg, 95% ethanol 160kg, isopropyl alcohol 320kg, glycerine 8kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet mop towel annex solution afterwards, make wet mop towel.
Embodiment 55
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 14kg, 95% ethanol 380kg, isopropyl alcohol 150kg, glycerine 7kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet tissue annex solution afterwards, make wet tissue.
Embodiment 56
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 11kg, 95% ethanol 390kg, isopropyl alcohol 120kg, glycerine 10kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet tissue annex solution afterwards, make wet tissue.
Embodiment 57
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 20kg, 95% ethanol 165kg, isopropyl alcohol 360kg, glycerine 8kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet tissue annex solution afterwards, make wet tissue.
Embodiment 58
According to following steps preparing product: add 100L purified water in preparing tank, bronopol 0.5kg, 20% hexamethylene aqueous solution 16kg, 95% ethanol 390kg, isopropyl alcohol 170kg, hyaluronic acid 7 kg is added successively under stirring, finish stirring to stop after 5 ~ 10 minutes stirring, add purified water to 1000kg, continue stirring 15 minutes.Inspection, be qualifiedly adsorbed in non-woven fabrics as wet tissue annex solution afterwards, make wet tissue.
Embodiment 59
Spray is prepared: in preparing tank, add 50L purified water according to following steps, add bronopol 0.3kg, 20% hexamethylene aqueous solution 15kg, isopropyl alcohol 440kg under stirring successively, finish stirring stop after 5 ~ 10 minutes stir, add purified water to 1000kg, continue stirring 15 minutes.Inspection, qualified after be sub-packed in band hand pump spray bottle in.
Claims (2)
1. by the percentage by weight of poly hexamethylene biguanide (PHMB) or its salt be 0.01% ~ 2%, the percentage by weight sum of isopropyl alcohol and ethanol 25 ~ 58%, surplus is the application of feedstock composition in preparation antimicrobial products that water forms.
2. the application of composition described in claim 1 in preparation antimicrobial products, is characterized in that: the percentage by weight of poly hexamethylene biguanide or its salt is 0.3%, the percentage by weight sum of isopropyl alcohol and ethanol is 48%.
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| CN103210948A (en) * | 2013-05-07 | 2013-07-24 | 江苏辉丰农化股份有限公司 | Bactericide for controlling fruit tree diseases |
| CN103283722A (en) * | 2013-07-02 | 2013-09-11 | 宁波华欣医疗器械有限公司 | Compound disinfectant for hospital and application thereof |
| WO2019140408A1 (en) | 2018-01-14 | 2019-07-18 | Collidion, Inc. | Compositions, kits, methods and uses for cleaning, disinfecting, sterilizing and/or treating |
| CN109463405A (en) * | 2018-11-20 | 2019-03-15 | 广州汇芬生物科技有限公司 | A kind of pet is dispelled taste thimerosal |
| CN111642512A (en) * | 2020-03-12 | 2020-09-11 | 天天向上(宁波)医疗科技有限公司 | High-efficiency disinfectant and preparation method and use method thereof |
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