CN111110832A - A preparation containing snail extractive solution and Chinese Holly extract for treating wound and scar, and its preparation method - Google Patents
A preparation containing snail extractive solution and Chinese Holly extract for treating wound and scar, and its preparation method Download PDFInfo
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- CN111110832A CN111110832A CN201811196999.6A CN201811196999A CN111110832A CN 111110832 A CN111110832 A CN 111110832A CN 201811196999 A CN201811196999 A CN 201811196999A CN 111110832 A CN111110832 A CN 111110832A
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- snail
- purified water
- chinese holly
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- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 241000237858 Gastropoda Species 0.000 title claims abstract description 33
- 231100000241 scar Toxicity 0.000 title claims abstract description 25
- 235000002710 Ilex cornuta Nutrition 0.000 title claims abstract description 19
- 241001310146 Ilex cornuta Species 0.000 title claims abstract description 19
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 title claims abstract description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000008213 purified water Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 206010052428 Wound Diseases 0.000 claims abstract description 21
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 16
- 208000032544 Cicatrix Diseases 0.000 claims abstract description 15
- 230000037387 scars Effects 0.000 claims abstract description 15
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- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 13
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 8
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 8
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims abstract description 8
- 102000008186 Collagen Human genes 0.000 claims abstract description 8
- 108010035532 Collagen Proteins 0.000 claims abstract description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 8
- 241001494479 Pecora Species 0.000 claims abstract description 8
- 229930003571 Vitamin B5 Natural products 0.000 claims abstract description 8
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 8
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- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims abstract description 8
- 229960002079 calcium pantothenate Drugs 0.000 claims abstract description 8
- 229920001436 collagen Polymers 0.000 claims abstract description 8
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- KKOXKGNSUHTUBV-UHFFFAOYSA-N racemic zingiberene Natural products CC(C)=CCCC(C)C1CC=C(C)C=C1 KKOXKGNSUHTUBV-UHFFFAOYSA-N 0.000 claims abstract description 8
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- KKOXKGNSUHTUBV-LSDHHAIUSA-N zingiberene Chemical compound CC(C)=CCC[C@H](C)[C@H]1CC=C(C)C=C1 KKOXKGNSUHTUBV-LSDHHAIUSA-N 0.000 claims abstract description 8
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- 244000197580 Poria cocos Species 0.000 claims abstract description 6
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- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 5
- 244000077995 Coix lacryma jobi Species 0.000 claims abstract description 5
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- 238000003756 stirring Methods 0.000 claims description 24
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- 230000001954 sterilising effect Effects 0.000 claims description 6
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- 210000004027 cell Anatomy 0.000 abstract description 14
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- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract description 6
- 230000008485 antagonism Effects 0.000 abstract description 6
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Classifications
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- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- A61K31/015—Hydrocarbons carbocyclic
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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Abstract
The preparation for treating wounds and scars comprises 3-5 g of coix seed extract, 1-3 g of chitosan, 3-6 g of vitamin B5, 2-6 g of vitamin C, 3-5 g of allantoin, 3-15 g of polyvinyl alcohol PVA, 5-20 ml of Chinese holly extract, 5-15 ml of centella extract, 5-10 ml of zingiberene factor, 3-5 g of aloe extract, 2-5 ml of sheep placenta, 15-25 ml of snail extract, 0.5ml of propylene glycol, 5-10 ml of hyaluronic acid, 2-6 ml of collagen extract, 2-4 g of poria cocos extract and 4-10 g of potassium sorbate, and the balance is purified water according to the preparation of 100 ml. The preparation can penetrate into skin surface cells, can quickly activate the phagocytosis and melanin-dissolving capacity of basal layer MB cells, effectively and directly reach damaged skin y tissues, promote blood circulation, enhance epidermal cell metabolism, expel scar tissue pigments, simultaneously effectively promote cell regeneration, prevent the damaged skin from generating antagonism and variation, smooth lymph fluid circulation function, prevent histamine antagonism capacity, recover the integrity and complexion of the skin, and furthest relieve pain and psychological burden of patients.
Description
Technical Field
The invention belongs to the technical field of wound or scar repair, and particularly relates to a preparation for treating wounds and scars by using snail extracting solution and Chinese holly extracting solution and a preparation method thereof.
Background
The trauma and scar are the local symptoms that the damage of physical, biological, chemical and other factors acts on the skin soft tissue of a human body, the severe damage of the skin soft tissue can not be completely and normally repaired, and the fiber tissue replaces and repairs the remained skin, thereby affecting the appearance and the function. The scar brings great physical and mental pains to patients, especially scars left after burns, scalds and serious trauma. The period of several years during the scar hyperplastic phase is almost overwhelming for the patient. The later atrophy period causes the patients to have complete facial disabilities and dysfunction, which causes great physical and cardiac double disorders. The acne scar left in the youth period is the 'whelk mark' which cannot be worn out. At present, most scar-removing products in the market are mainly prepared by extracting plants and adding chemical components, molecular cells of the plants are larger than cells of human bodies, although the products have certain effects, the products can have adverse effects when being used as non-absorbable substances, cell conversion and metabolism are retarded, and cell channels can be blocked possibly to form hyperplasia or secondary infection; meanwhile, domestic and foreign treatment methods such as laser, freezing, skin grafting and the like have relatively high cost, and meanwhile, the effect is not very obvious and the safety is not high.
Disclosure of Invention
In order to solve the technical problems, the invention provides a preparation for treating wounds and scars by using snail extracting solution and Chinese holly extracting solution and a preparation method thereof.
The preparation for treating wounds and scars comprises 3-5 g of coix seed extract, 1-3 g of chitosan, 3-6 g of vitamin B5, 2-6 g of vitamin C, 3-5 g of allantoin, 3-15 g of polyvinyl alcohol PVA, 5-20 ml of Chinese holly extract, 5-15 ml of centella asiatica extract, 5-10 ml of zingiberene factor, 3-5 g of aloe extract, 2-5 ml of sheep placenta, 15-25 ml of snail extract, 0.5ml of propylene glycol, 5-10 ml of hyaluronic acid, 2-6 ml of collagen extract, 2-4 g of poria cocos extract, 4-10 g of potassium sorbate, and the balance being purified water according to the preparation of 100 ml.
The preparation method of the preparation for curing wounds and scars by the snail extract and the Chinese holly extract comprises the following steps:
step A: adding appropriate amount of purified water into Coicis semen extract, stirring for dissolving, adding Aloe extract, stirring, and standing at room temperature;
and B: adding a proper amount of purified water into a measuring cup, stirring until the chitosan is dissolved, stirring for dissolving for about 5-7 minutes, and standing at normal temperature for later use after all the chitosan is dissolved;
and C: respectively putting vitamin C and vitamin B5 into two test tubes or measuring cups, respectively adding a proper amount of purified water, completely dissolving, and standing at normal temperature for later use;
step D, pouring an appropriate amount of purified water into the measuring cup, stirring uniformly, completely dissolving, and standing at normal temperature for later use;
step E: taking a proper amount of purified water to completely dissolve polyvinyl alcohol, and standing at normal temperature for later use;
step F: adding the preparation prepared in the steps A to E into a measuring cup, and adding the snail extracting solution and the propylene glycol into the measuring cup in sequence and stirring uniformly for later use;
and G, adding the Chinese holly extract, the asiatic centella extract, the zingiberene factor, the sheep placenta, the propylene glycol, the hyaluronic acid, the collagen extract and the poria cocos extract into the preparation obtained in the step F, uniformly stirring, and finally adding potassium sorbate and purified water, and uniformly stirring to prepare 100 ml.
Further, the sequence of the step a to the step E can be interchanged and adjusted.
Furthermore, the addition amount of the snail extract in the step F is 20 ml.
Furthermore, the snail extract is prepared by extracting snails cultured in an aseptic culture environment, extracting the snails after disinfection and sterilization in an aseptic room, and finally performing three-stage filtration and sterilization treatment on the snail extract by a first-stage 0.45 micron filter element, a second-stage 0.22 micron filter element and a third-stage 0.22 micron filter element of a filter device.
The preparation for treating wounds and scars and containing the snail extract comprises 3-5 g of coix seed extract, 1-3 g of chitosan, 3-6 g of vitamin B5, 2-6 g of vitamin C, 3-5 g of allantoin, 3-15 g of polyvinyl alcohol PVA, 5-20 ml of Chinese holly extract, 5-15 ml of centella extract, 5-10 ml of zingiberene factor, 3-5 g of aloe extract, 2-5 ml of sheep placenta, 15-25 ml of snail extract, 0.5ml of propylene glycol, 5-10 ml of hyaluronic acid, 2-6 ml of collagen extract, 2-4 g of poria extract, 4-10 g of potassium sorbate, and the balance being purified water according to the preparation of 100 ml. The preparation can penetrate into skin surface cells, can quickly activate the phagocytosis and melanin-dissolving capacity of basal layer MB cells, effectively and directly reach damaged skin y tissues, promote blood circulation, enhance epidermal cell metabolism, expel scar tissue pigments, simultaneously effectively promote cell regeneration, prevent the damaged skin from generating antagonism and variation, smooth lymph fluid circulation function, prevent histamine antagonism capacity, recover the integrity and complexion of the skin, and furthest relieve pain and psychological burden of patients.
Detailed Description
Examples
A preparation for treating wounds and scars with snail extract and Chinese holly extract comprises 3-5 g of coix seed extract, 1-3 g of chitosan, 3-6 g of vitamin B5, 2-6 g of vitamin C, 3-5 g of allantoin, 3-15 g of polyvinyl alcohol PVA, 5-20 ml of Chinese holly extract, 5-15 ml of centella extract, 5-10 ml of zingiberene factor, 3-5 g of aloe extract, 2-5 ml of sheep placenta, 15-25 ml of snail extract, 0.5ml of propylene glycol, 5-10 ml of hyaluronic acid, 2-6 ml of collagen extract, 2-4 g of poria extract and 4-10 g of potassium sorbate, and the balance being purified water according to the preparation of 100 ml.
Examples 1 to 5
Five data sampling experiments from example 1 to example 5 were carried out according to the above formulation ratios of the snail extract and Chinese holly extract for healing wounds and scars, and the sampling specifications are shown in Table 1:
TABLE 1
Example 6
The experimental data of examples 1 to 5 were sampled, respectively, and the desired formulations were prepared by the following steps, respectively:
step A: adding appropriate amount of purified water into Coicis semen extract, stirring for dissolving, adding Aloe extract, stirring, and standing at room temperature;
and B: adding a proper amount of purified water into a measuring cup, stirring until the chitosan is dissolved, stirring for dissolving for about 5-7 minutes, and standing at normal temperature for later use after all the chitosan is dissolved;
and C: respectively putting vitamin C and vitamin B5 into two test tubes or measuring cups, respectively adding 10ml of purified water, completely dissolving, and standing at normal temperature for later use;
step D, pouring an appropriate amount of purified water into the measuring cup, stirring uniformly, completely dissolving, and standing at normal temperature for later use;
step E: taking a proper amount of purified water to completely dissolve polyvinyl alcohol, and standing at normal temperature for later use;
step F: adding the preparation prepared in the steps A to E into a measuring cup, and adding the snail extracting solution and the propylene glycol into the measuring cup in sequence and stirring uniformly for later use;
and G, adding the Chinese holly extract, the asiatic centella extract, the zingiberene factor, the sheep placenta, the propylene glycol, the hyaluronic acid, the collagen extract and the poria cocos extract into the preparation obtained in the step F, uniformly stirring, and finally adding potassium sorbate and purified water, and uniformly stirring to prepare 100 ml.
Preferably, the sequence of the steps A to E can be interchanged and adjusted.
More preferably, the amount of the snail extract added in step F is 20 ml.
More preferably, the snail extract is prepared by extracting snails cultured in an aseptic culture environment, performing disinfection and sterilization in an aseptic room, extracting, and performing three-stage filtration and sterilization treatment on a first stage 0.45 micron filter element, a second stage 0.22 micron filter element and a third stage 0.22 micron filter element of a filter device.
The preparation process for preparing 100ml of preparation can be increased in proportion according to the proportioning mode for batch production.
According to experimental data sampling in examples 1-5, a preparation containing snail extract for healing wounds and scars is prepared according to the preparation process of example 6, and five groups of Beijing guinea pig 43 g adult mice are used for wound repair tests, wherein two groups in each group are respectively H group (H1, H2), I group (I1, I2), J group (J1, J2), K (K1, K2), L (L1, L2), and the preparation is sprayed on the leg wound surface of the Beijing guinea pig, and the size of the wound surface is 1 cm over the periphery of the wound surface when the preparation is sprayed, so that bacteria in the range of 1 cm of the wound surface are difficult to invade the wound surface, and a large amount of white cells generated by skin stimulation are reduced to block repair channels. Through tests, five groups of Beijing guinea pigs have very good leg wound repair and obtain expected effects.
The preparation can penetrate into skin surface cells, can quickly activate the phagocytosis and melanin-dissolving capacity of basal layer MB cells, effectively and directly reach damaged skin y tissues, promote blood circulation, enhance epidermal cell metabolism, expel scar tissue pigments, simultaneously effectively promote cell regeneration, prevent the damaged skin from generating antagonism and variation, smooth lymph fluid circulation function, prevent histamine antagonism capacity, recover the integrity and complexion of the skin, and furthest relieve pain and psychological burden of patients.
The present invention has been described in detail with reference to the examples and comparative examples, but the present invention is not limited to the examples and comparative examples, and various changes can be made without departing from the concept of the present invention within the knowledge of those skilled in the art.
Claims (5)
1. A preparation for treating wounds and scars by using snail extract and Chinese holly extract is characterized in that: the preparation method comprises 3-5 g of coix seed extract, 1-3 g of chitosan, 3-6 g of vitamin B5, 2-6 g of vitamin C, 3-5 g of allantoin, 3-15 g of polyvinyl alcohol PVA, 5-20 ml of Chinese holly extract, 5-15 ml of centella asiatica extract, 5-10 ml of zingiberene factor, 3-5 g of aloe extract, 2-5 ml of sheep placenta, 15-25 ml of snail extract, 0.5ml of propylene glycol, 5-10 ml of hyaluronic acid, 2-6 ml of collagen extract, 2-4 g of poria cocos extract, 4-10 g of potassium sorbate, and the balance of 100ml of preparation is purified water.
2. The method for preparing a preparation for healing wounds and scars from snail extract and Chinese holly extract as claimed in claim 1, comprising the steps of
Step A: adding appropriate amount of purified water into Coicis semen extract, stirring for dissolving, adding Aloe extract, stirring, and standing at room temperature;
and B: adding a proper amount of purified water into a measuring cup, stirring until the chitosan is dissolved, stirring for dissolving for about 5-7 minutes, and standing at normal temperature for later use after all the chitosan is dissolved;
and C: respectively putting vitamin C and vitamin B5 into two test tubes or measuring cups, respectively adding a proper amount of purified water, completely dissolving, and standing at normal temperature for later use;
step D, pouring an appropriate amount of purified water into the measuring cup, stirring uniformly, completely dissolving, and standing at normal temperature for later use;
step E: taking a proper amount of purified water to completely dissolve polyvinyl alcohol, and standing at normal temperature for later use;
step F: adding the preparation prepared in the steps A to E into a measuring cup, and adding the snail extracting solution and the propylene glycol into the measuring cup in sequence and stirring uniformly for later use;
and G, adding the Chinese holly extract, the asiatic centella extract, the zingiberene factor, the sheep placenta, the propylene glycol, the hyaluronic acid, the collagen extract and the poria cocos extract into the preparation obtained in the step F, uniformly stirring, and finally adding potassium sorbate and purified water, and uniformly stirring to prepare 100 ml.
3. The method for preparing a preparation for healing wounds and scars by using snail extract and Chinese holly extract as claimed in claim 2, wherein the sequence of the steps A to E can be adjusted interchangeably.
4. The method for preparing a preparation for healing wounds and scars from the extract solution of snail and the extract solution of Chinese holly according to any one of claims 2 to 3, wherein the amount of the extract solution of snail added in step F is 20 ml.
5. A method for preparing a preparation for treating wounds and scars by using snail extract and poncirus trifoliata extract as claimed in any one of claims 2-3, wherein the snail extract is prepared by breeding snails in an aseptic breeding environment, and is extracted after disinfection and sterilization in an aseptic room, and finally is subjected to three-stage filtration and sterilization treatment by using a filter device, wherein the filter device comprises a first-stage 0.45 micron filter element, a second-stage 0.22 micron filter element and a third-stage 0.22 micron filter element.
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| CN114732860A (en) * | 2021-01-07 | 2022-07-12 | 云南五维宜康生物科技有限公司 | A compound medicinal composition for treating wound and scar, and its preparation method |
| WO2023172215A1 (en) * | 2022-03-11 | 2023-09-14 | Yildiz Teknik Universitesi | A cosmetic product with moisturizing feature |
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