CN110448601B - Traditional Chinese medicine composition for treating migraine - Google Patents

Traditional Chinese medicine composition for treating migraine Download PDF

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CN110448601B
CN110448601B CN201910928854.9A CN201910928854A CN110448601B CN 110448601 B CN110448601 B CN 110448601B CN 201910928854 A CN201910928854 A CN 201910928854A CN 110448601 B CN110448601 B CN 110448601B
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李广
位磊
张世葳
唐宋
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Henan University of Traditional Chinese Medicine HUTCM
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Abstract

The invention relates to a traditional Chinese medicine composition for treating migraine, which can effectively solve the medication problem of the migraine and adopts the technical scheme that the traditional Chinese medicine is prepared from the following raw material medicines by weight: 20-40g of kudzuvine root, 5-15g of notopterygium root, 7-17g of angelica dahurica, 5-15g of divaricate saposhnikovia root, 5-15g of szechuan lovage rhizome, 1-5g of manchurian wildginger, 10-20g of vinegar rhizoma corydalis, 3-9g of Chinese honeylocust spine, 5-15g of Chinese thorowax root, 5-15g of baical skullcap root, 0.5-1.5g of centipede, 20-40g of white paeony root and 5-13g of liquoric root.

Description

Traditional Chinese medicine composition for treating migraine
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating migraine.
Background
Migraine is a common disease in outpatient clinic of traditional Chinese medicine, is most common in patients with clinical symptoms caused by exogenous wind evil and meridian stasis, and can be seen only by wind because the head is the confliction of all yang, wind is the yang evil, the nature is mild, and the head is higher than the vertex. The theory of Su Wen, Taiyin and Yang Ming Lun states: the head is the place where the liver and gallbladder pass, the liver meridian runs at the vertex of the head, the gallbladder meridian runs at both sides of the head, the two meridians mainly dredge qi, and qi stagnation is caused by unsmooth dredging. In addition, the head is easily injured by external factors, and women often suffer from menstrual headache due to internal stagnation of blood stasis, so that the obstruction of collaterals by blood stasis is an important factor of headache.
Disclosure of Invention
In view of the above situation, in order to solve the defects of the prior art, the present invention aims to provide a traditional Chinese medicine composition for treating migraine, which can effectively solve the medication problem of migraine.
The technical scheme of the invention is that the traditional Chinese medicine is prepared from the following raw material medicines by weight: 20-40g of kudzuvine root, 5-15g of notopterygium root, 7-17g of angelica dahurica, 5-15g of divaricate saposhnikovia root, 5-15g of szechuan lovage rhizome, 1-5g of manchurian wildginger, 10-20g of vinegar rhizoma corydalis, 3-9g of Chinese honeylocust spine, 5-15g of Chinese thorowax root, 5-15g of baical skullcap root, 0.5-1.5g of centipede, 20-40g of white paeony root and 5-13g of.
The traditional Chinese medicine composition is scientific in formula and reasonable in compatibility, has the effects of dispelling wind, dredging collaterals, promoting blood circulation to remove blood stasis and relieving spasm and pain, and is an innovation in medicines for treating migraine.
Detailed Description
The following examples further illustrate the embodiments of the present invention in detail.
Example 1
When the invention is implemented, the invention can be prepared by the following raw material medicaments by weight: 21g of kudzuvine root, 6g of notopterygium root, 8g of angelica dahurica, 6g of divaricate saposhnikovia root, 6g of szechuan lovage rhizome, 2g of asarum, 11g of vinegar rhizoma corydalis, 4g of Chinese honeylocust spine, 6g of Chinese thorowax root, 6g of baical skullcap root, 0.6g of centipede, 21g of white paeony root and 6g of liquoric root.
Example 2
When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 30g of kudzuvine root, 10g of notopterygium root, 12g of angelica dahurica, 10g of divaricate saposhnikovia root, 10g of szechuan lovage rhizome, 3g of asarum, 15g of vinegar rhizoma corydalis, 6g of Chinese honeylocust spine, 10g of Chinese thorowax root, 10g of baical skullcap root, 1g of centipede, 30g of white paeony root and 9g of liquoric root.
Example 3
When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 39g of kudzuvine root, 14g of notopterygium root, 16g of angelica dahurica, 14g of divaricate saposhnikovia root, 14g of szechuan lovage rhizome, 4g of asarum, 19g of vinegar rhizoma corydalis, 8g of Chinese honeylocust spine, 14g of Chinese thorowax root, 14g of baical skullcap root, 1.5g of centipede, 39g of white paeony root and 12g of liquoric root.
The traditional Chinese medicine composition can be prepared into various applicable dosage forms such as decoction, powder (powder), tablets, granules, pills, capsules and the like according to the actual clinical needs by a conventional preparation method, and the decoction prepared by the conventional method is provided below, and specifically comprises the following components: mixing radix Puerariae, Notopterygii rhizoma, radix Angelicae Dahuricae, radix Saposhnikoviae, rhizoma Ligustici Chuanxiong, herba asari, rhizoma corydalis processed with vinegar, spina Gleditsiae, bupleuri radix, Scutellariae radix, Scolopendra, radix Paeoniae alba and Glycyrrhrizae radix together, placing into a medicinal jar, soaking in water for 30-60min, decocting with strong fire to boil, decocting with slow fire for 20-30min, filtering to obtain filtrate, soaking the residue in water, decocting with strong fire to boil, decocting with slow fire for 20-30min, filtering to obtain filtrate, mixing the filtrates, and mixing.
In the components of the invention:
kudzu root: sweet, pungent and cool. Has the functions of expelling pathogenic factors from muscles, allaying fever, promoting eruption, promoting the production of body fluid to quench thirst, invigorating yang and stopping diarrhea. It is commonly indicated for exterior syndrome with fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging and diarrhea due to spleen deficiency.
Notopterygium root: medicine property: pungent and bitter with warm nature. It enters bladder and kidney meridians. The functional indications are as follows: dispel exterior cold, dispel wind-damp, benefit joint, alleviate pain. It is mainly indicated for wind-cold, headache without sweating, arthralgia due to wind-cold-dampness, edema due to wind-dampness, sores and ulcers with swelling.
Radix angelicae: warm in nature, pungent in flavor, entering lung, spleen and stomach meridians. It is the channel-guiding herb for yangming meridians. The functional indications are as follows: dispel wind-damp, activate blood and discharge pus, promote granulation and alleviate pain. Can be used for treating headache, toothache, nasosinusitis, intestinal wind, hemorrhoid, leucorrhea with reddish discharge, carbuncle, cellulitis, pyocutaneous disease, and skin pruritus.
Wind prevention: pungent and sweet in flavor, slightly warm in nature. It enters bladder, liver and spleen meridians. The efficacy is as follows: dispel wind, relieve exterior syndrome, subdue dampness, alleviate pain, stop spasm and stop convulsions. The main treatment is as follows: exterior syndrome due to exogenous pathogens, rubella with pruritus, rheumatic arthralgia, and tetanus.
Ligusticum wallichii: pungent and warm. Entering liver and gallbladder meridians. Move qi and relieve depression, dispel wind-dryness and dampness, activate blood and alleviate pain. It is indicated for wind-cold headache, dizziness, hypochondriac pain, abdominal pain, cold arthralgia, spasm of tendons, amenorrhea, dystocia, postpartum pain due to blood stasis, carbuncle, cellulitis, sore and ulcer. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia.
Asarum: dispel wind, dispel cold, move water and induce resuscitation. Can be used for treating wind-cold headache, nasosinusitis, odontalgia, phlegm and fluid retention, cough, and rheumatalgia.
Vinegar rhizoma corydalis: pungent, bitter, warm and non-toxic. Enter liver, stomach and heart meridians. Promoting blood circulation, activating qi-flowing, and relieving pain. Vinegar rhizoma corydalis: mixing rhizoma corydalis with vinegar, soaking until the vinegar is absorbed completely, parching with slow fire to slightly dry, taking out, and cooling. Or decocting rhizoma corydalis in vinegar in a pot until the vinegar is completely absorbed, oven drying, taking out, and cooling. The vinegar processed product has analgesic effect.
Spina gleditsiae: pungent and warm. It enters lung and liver meridians. It is mainly used for treating carbuncle, cellulitis, pyogenic infections, scrofula, skin sore, intractable tinea, puerperal hypogalactia, retained afterbirth and leprous pestilential wind.
Bupleurum root: nature, flavor and meridian tropism: slightly cold in nature, bitter and pungent in flavor, entering liver and gallbladder meridians, and having the effects of soothing liver, promoting bile flow, dispelling qi, resolving stagnation and dissipating fire. The functional indications are as follows: to expel pathogenic factors from the exterior, release heat, soothe the liver, relieve depression and lift yang qi. Can be used for treating stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, metrorrhagia, and menoxenia.
Scutellaria baicalensis: bitter and cold. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. The functions and indications are as follows: clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding, preventing miscarriage and reducing blood pressure. Can be used for treating chest distress, nausea, damp-heat, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Centipede: extinguish wind and relieve spasm, counteract toxic pathogen and dissipate nodulation, dredge meridians to stop pain. Can be used for treating spasm, convulsion, pyocutaneous disease, toxic swelling, lymphoid tuberculosis, intractable rheumatism, and intractable headache.
White peony root: nourish blood and astringe yin, soften liver to alleviate pain, and calm liver yang. Can be used for treating menoxenia due to liver blood deficiency; chest, hypochondrium, stomach and abdomen pain caused by liver-spleen disharmony, limb spasm and acute pain; headache and vertigo caused by hyperactivity of liver-yang.
Licorice root: sweet taste, mild nature, entering heart, spleen, lung and stomach meridians. Raw materials are cool, and can purge fire, remove toxicity, relieve spasm and alleviate pain; moxibustion is warm in nature and can dissipate exterior cold, tonify middle-jiao and replenish qi. In addition, gan Cao is good at harmonizing property of herbs and removing toxicity of various herbs.
The main clinical manifestations of migraine are: paroxysmal lateral throbbing headache, occasional total headache, moderate or severe pain accompanied by nausea and vomiting or photophobia, phonophobia, lasting 4-72 hours. Periodic attacks, without any abnormality in the interval of the attacks. Dark tongue, or dark sublingual veins, thready and wiry or thready and unsmooth pulse. The formula of the invention is developed on the basis of the basic theory of traditional Chinese medicine, wherein kudzu root treats wind of head, notopterygium root treats wind of channels and collaterals, dahurian angelica root is aromatic and has the effects of dredging orifices and treating wind of head and face, and divaricate saposhnikovia root is a moisturizer of wind medicine and can dispel wind of the whole body; the radix bupleuri can soothe liver and regulate qi, and can introduce medicines into shaoyang channels; baikal skullcap root, radix Scutellariae and Bupleurum root, all of them are essential drugs for treating headache due to shaoyang meridian; radix Paeoniae alba and Glycyrrhrizae radix decoction, composed of radix Paeoniae alba and Glycyrrhrizae radix, is used for treating jumping pain, dragging pain or spasm of tendons of various parts of body; the rhizoma ligustici wallichii and the vinegar rhizoma corydalis are common medicines for promoting blood circulation, regulating qi and relieving pain, and can be used twice for severe pain; spina gleditsiae and radix puerariae and radix angelicae dahuricae are matched to dispel wind, dissipate blood stasis, dredge collaterals and relieve pain; a small amount of centipedes are added to search wind and remove meridian obstruction to relieve stubborn pain, the whole formula has the effects of dispelling wind and activating blood circulation and relieving spasm and pain, the migraine is treated by utilizing the comprehensive effects of the traditional Chinese medicines, and the traditional Chinese medicine is nontoxic and harmless to human bodies, has good curative effect and safe medication, and is fully proved by clinical experiments, and relevant clinical experimental data are as follows:
the traditional Chinese medicine composition takes decoction as an example,
1 clinical data
1.1 case data outpatient migraine patients were randomly selected from 60 cases, 25 cases in males and 35 cases in females; the age is 62 years maximum, 16 years minimum, and the average age is 32.6 +/-2.8 years; the course of the disease is 0.5-11 years. All the above cases were examined by cranial CT to eliminate nervous system organic lesions.
1.2 the diagnosis standard refers to the diagnosis of migraine in the diagnostic standard for neurologic diseases published by the 2009 science and technology literature publisher and the diagnosis standard for headache in the diagnostic efficacy standard for traditional Chinese medicine syndrome published by the national traditional Chinese medicine administration in 2019.
1.2.1 paroxysmal, one-sided throbbing headache, occasional total headache, moderate or severe pain with nausea and vomiting or photophobia, phonophobia, lasting 4-72 hours. Periodic attacks, without any abnormality in the interval of the attacks.
1.2.2 dark purple tongue, or dark purple sublingual vein, and thready and wiry or thready and unsmooth pulse.
1.2.3 glaucoma, epileptic headache, cerebrovascular malformation or cerebral artery disease, etc. are excluded.
1.3 inclusion criteria: meeting the diagnosis standard of migraine; ② the age is 16-62 years old; and the experiment is agreed to take part.
1.4 exclusion criteria: (ii) those under age 16 or over age 62; ② women in gestation period; ③ patients with serious diseases such as cardiovascular diseases, pulmonary diseases, hepatic diseases, renal diseases, hemopoietic diseases, etc.; organic lesion of nervous system.
2 treatment regimen
The decoction prepared by the embodiment 2 of the invention is taken once every 1 hour after breakfast and supper, 200ml is taken every time, 10 days is taken as a treatment course, and the treatment effect is counted after 2-3 treatment courses of administration. During the treatment period, it is advisable to regulate the emotion and avoid eating spicy food.
3, the curative effect judgment standard refers to the curative effect standard of the wind syndrome in the 'traditional Chinese medicine disease diagnosis curative effect standard' published by the State administration of traditional Chinese medicine in 2019.
And (3) curing: headache symptom disappeared, and each laboratory examination was normal.
Improvement: headache was reduced, onset time was shortened or the cycle was prolonged, and laboratory examinations were improved.
The disease is not cured: headache and blood pressure were unchanged.
The total of 60 patients with 4 results are cured by 40 patients, the obvious effect is 18 patients, the ineffective effect is 2 patients, and the total effective rate is 96.67 percent.
The traditional Chinese medicine formula of the invention is prepared into other dosage forms or other embodiments are used, the same or similar results are obtained in experiments, the detailed description is avoided, and the application requests to protect the traditional Chinese medicine formula (combination invention) rather than the dosage form or the preparation method, so that any dosage form prepared by adopting the traditional Chinese medicine formula of the application and the medicine for treating migraine belong to the protection scope of the application.
5. Conclusion
The traditional Chinese medicine composition has scientific components, rich raw materials, low price, reasonable compatibility and mutual support, has the effects of dispelling wind, promoting blood circulation and relieving spasm and pain, is effectively used for treating the external wind evil and the migraine caused by meridian stasis, is nontoxic and harmless to human bodies, has good curative effect and safe medication, has the effective rate of more than 96 percent, is a great innovation in traditional Chinese medicines, and has practical clinical significance.

Claims (4)

1. The traditional Chinese medicine composition for treating migraine is characterized by being prepared from the following raw material medicines in parts by weight: 20-40g of kudzuvine root, 5-15g of notopterygium root, 7-17g of angelica dahurica, 5-15g of divaricate saposhnikovia root, 5-15g of szechuan lovage rhizome, 1-5g of manchurian wildginger, 10-20g of vinegar rhizoma corydalis, 3-9g of Chinese honeylocust spine, 5-15g of Chinese thorowax root, 5-15g of baical skullcap root, 0.5-1.5g of centipede, 20-40g of white paeony root and 5-13g of.
2. The traditional Chinese medicine composition for treating migraine according to claim 1, which is prepared from the following raw materials by weight: 21g of kudzuvine root, 6g of notopterygium root, 8g of angelica dahurica, 6g of divaricate saposhnikovia root, 6g of szechuan lovage rhizome, 2g of asarum, 11g of vinegar rhizoma corydalis, 4g of Chinese honeylocust spine, 6g of Chinese thorowax root, 6g of baical skullcap root, 0.6g of centipede, 21g of white paeony root and 6g of liquoric root.
3. The traditional Chinese medicine composition for treating migraine according to claim 1, which is prepared from the following raw materials by weight: 30g of kudzuvine root, 10g of notopterygium root, 12g of angelica dahurica, 10g of divaricate saposhnikovia root, 10g of szechuan lovage rhizome, 3g of asarum, 15g of vinegar rhizoma corydalis, 6g of Chinese honeylocust spine, 10g of Chinese thorowax root, 10g of baical skullcap root, 1g of centipede, 30g of white paeony root and 9g of liquoric root.
4. The traditional Chinese medicine composition for treating migraine according to claim 1, which is prepared from the following raw materials by weight: 39g of kudzuvine root, 14g of notopterygium root, 16g of angelica dahurica, 14g of divaricate saposhnikovia root, 14g of szechuan lovage rhizome, 4g of asarum, 19g of vinegar rhizoma corydalis, 8g of Chinese honeylocust spine, 14g of Chinese thorowax root, 14g of baical skullcap root, 1.5g of centipede, 39g of white paeony root and 12g of liquoric root.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190381A1 (en) * 2001-02-02 2003-10-09 Bland Jeffrey S. Medical composition for balancing bodily processes
CN105663785A (en) * 2016-02-16 2016-06-15 成都市飞龙水处理技术研究所青白江第一分所 Traditional Chinese medicine composition for treating migraine and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030190381A1 (en) * 2001-02-02 2003-10-09 Bland Jeffrey S. Medical composition for balancing bodily processes
CN105663785A (en) * 2016-02-16 2016-06-15 成都市飞龙水处理技术研究所青白江第一分所 Traditional Chinese medicine composition for treating migraine and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"唐宋教授针药并用治疗丛集性头痛经验";位磊等;《中国中医药现代远程教育》;20150531;第13卷(第10期);第26-27页 *

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