CN111544507A

CN111544507A - Compound traditional Chinese medicine for treating blood stasis headache

Info

Publication number: CN111544507A
Application number: CN202010587687.9A
Authority: CN
Inventors: 常学辉; 张良芝; 郭健; 杜凤丽; 许培东; 张创业; 陈帅杰; 王冬莲
Original assignee: Henan University of Traditional Chinese Medicine HUTCM
Current assignee: Henan University of Traditional Chinese Medicine HUTCM
Priority date: 2020-06-24
Filing date: 2020-06-24
Publication date: 2020-08-18

Abstract

The invention relates to a compound traditional Chinese medicine for treating blood stasis headache, which can effectively solve the problem of good curative effect on the blood stasis headache, and adopts the technical scheme that the compound traditional Chinese medicine is prepared from the following raw materials by weight: 15-21g of salvia miltiorrhiza, 9-15g of rhizoma corydalis, 18-30g of white paeony root, 6-8g of peach seed, 3-6g of safflower, 9-15g of vinegar rhizoma cyperi, 6-9g of szechwan chinaberry fruit and 10-15g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine surface is soaked for 30-40min, the medicine is decocted with strong fire to boil, then the medicine is decocted with slow fire for 25-30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product. The traditional Chinese medicine composition has the advantages of rich raw materials, scientific and reasonable formula compatibility, mutual support of the components, blood circulation promoting, blood stasis removing, collateral dredging and pain relieving effects, and is an innovation of medicines for treating blood stasis headache.

Description

Compound traditional Chinese medicine for treating blood stasis headache

Technical Field

The invention relates to a medicine, in particular to a compound traditional Chinese medicine for treating blood stasis headache.

Background

Headache due to blood stasis is one of headache syndromes, with symptoms of dizziness and swelling, severe headache, fixed pain, intermittent onset, lingering and unhealed, tongue with blood stasis or purple dark, and unsmooth pulse. The clinical morbidity is high due to qi stagnation and blood stasis caused by long-term illness or remains after trauma, and statistics shows that the morbidity accounts for 50 percent of headache, dizziness and swelling, stabbing pain or jumping pain on one side or two sides, fixed pain, thin white or thin yellow tongue fur, dark tongue texture or ecchymosis or petechia, and wiry and slow pulse. The body health and normal life of a patient are seriously affected, and at present, the treatment of blood stasis headache is generally carried out by adopting a treatment rule of an addition and subtraction formula of decoction for promoting the restoration of consciousness and activating blood, and blood stasis dispelling, and scorpion, centipede, earthworm, angelica dahurica and other medicines are preferably added for severe pain; for patients with qi deficiency, radix astragali may be added. Generally, in the prescription, the dosage of red, white peony root, chuanxiong rhizome, etc. should be slightly larger. However, due to the problems of the prescription and the dosage, the use and the curative effect are not satisfactory, so the improvement and the innovation of the medicament for treating the blood stasis headache are imperative.

Disclosure of Invention

Aiming at the above situation, in order to overcome the defects of the prior art, the invention aims to provide a compound traditional Chinese medicine for treating blood stasis headache, which can effectively solve the problem of good curative effect on treating blood stasis headache.

The technical scheme of the invention is that a compound traditional Chinese medicine for treating blood stasis headache is prepared from the following raw material medicines by weight: 15-21g of salvia miltiorrhiza, 9-15g of rhizoma corydalis, 18-30g of white paeony root, 6-8g of peach seed, 3-6g of safflower, 9-15g of vinegar rhizoma cyperi, 6-9g of szechwan chinaberry fruit and 10-15g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine surface is soaked for 30-40min, the medicine is boiled with strong fire (big fire), then the medicine is boiled with slow fire (small fire) for 25-30min, and the medicine liquid is filtered to obtain the first medicine liquid; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

The traditional Chinese medicine composition has the advantages of rich raw materials, scientific and reasonable formula compatibility, mutual support of the components, effects of promoting blood circulation to remove blood stasis, dredging collaterals and relieving pain, is effectively used for treating blood stasis headache, and is an innovation in medicines for treating blood stasis headache.

Detailed Description

The following detailed description of the embodiments of the present invention will be given with reference to the accompanying specific cases and examples.

In particular, the present invention can be realized by the following examples.

Example 1

In specific implementation, the compound traditional Chinese medicine for treating blood stasis headache is prepared from the following raw material medicines in parts by weight: 18g of salvia miltiorrhiza, 12g of rhizoma corydalis, 24g of white paeony root, 7g of peach kernel, 4.5g of safflower, 12g of vinegar-processed rhizoma cyperi, 7.5g of szechwan chinaberry fruit and 12.5g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30-40min, the medicine is boiled by strong fire, then the medicine is decocted for 25-30min by slow fire, and the filtration is carried out to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

Example 2

In specific implementation, the compound traditional Chinese medicine for treating blood stasis headache is prepared from the following raw material medicines in parts by weight: 16g of salvia miltiorrhiza, 14g of rhizoma corydalis, 19g of white paeony root, 8g of peach kernel, 4g of safflower, 14g of rhizoma cyperi with vinegar, 7g of szechwan chinaberry fruit and 14g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30 to 40min, the medicine is boiled with strong fire, then the medicine is boiled with slow fire for 25 to 30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

Example 3

In specific implementation, the compound traditional Chinese medicine for treating blood stasis headache is prepared from the following raw material medicines in parts by weight: 20g of salvia miltiorrhiza, 10g of rhizoma corydalis, 29g of white paeony root, 6g of peach kernel, 6g of safflower, 10g of rhizoma cyperi with vinegar, 9g of szechwan chinaberry fruit and 11g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30 to 40min, the medicine is boiled with strong fire, then the medicine is boiled with slow fire for 25 to 30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

When the traditional Chinese medicine composition is produced specifically, the traditional Chinese medicine composition can be prepared into a traditional Chinese medicine preparation which can be taken medically, such as powder, pills, capsules, granules or paste and the like according to the actual needs of diseases, so the technical core claimed by the invention is the traditional Chinese medicine composition, and all the dosage forms which are prepared by adopting the traditional Chinese medicine composition and are suitable for being taken medically belong to the protection scope of the invention.

In the above medicament, wherein:

red sage root: bitter and slightly cold taste, and has effects of invigorating blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle, and can be used for treating thoracic obstruction, cardialgia, abdominal pain, abdominal mass, pain due to heat arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain;

rhizoma corydalis: rhizoma corydalis is also named as rhizoma corydalis, is warm in nature, pungent and bitter in flavor, enters heart, spleen, liver and lung, is a wonderful product for promoting blood circulation to remove blood stasis and promoting qi circulation to relieve pain, and is particularly known for relieving pain;

white peony root: bitter and sour in taste and slightly cold in nature, enter liver and spleen channels, and have the effects of nourishing blood, regulating menstruation, astringing yin, arresting sweating, softening liver, relieving pain and calming liver yang. It is commonly used for blood deficiency and chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, limb spasm pain, headache and vertigo;

peach kernel: bitter, sweet and flat taste, which is in the channels of heart, liver and large intestine, has the efficacies of activating blood circulation to dissipate blood stasis, relaxing bowel, relieving cough and asthma, and is used for amenorrhea and dysmenorrhea, abdominal mass and lump, pulmonary abscess and intestinal abscess, traumatic injury, intestinal dryness and constipation, cough and asthma;

safflower: pungent and warm in property, enter heart and liver meridians, activate blood and dredge meridians, dissipate blood stasis and alleviate pain, and are helpful for treating amenorrhea, dysmenorrhea, lochiorrhea, chest stuffiness and pain, abdominal pain due to stasis, stabbing pain in chest and hypochondrium, traumatic injury, sore and ulcer with swelling and pain. Has the effects of promoting blood circulation, removing blood stasis, eliminating dampness and swelling, and can be used by pregnant women;

vinegar processed nutgrass galingale rhizome: pungent, slightly bitter and sweet in flavor and mild in nature. Has the effects of soothing liver, regulating qi, regulating menstruation and relieving pain;

toosendan fruit: bitter and cold in flavor, entering liver, small intestine and bladder meridians, soothing liver and clearing heat. Move qi and alleviate pain. Killing parasites, and can be used for treating liver depression, fire, distending pain of chest, hypochondrium, stomach and abdomen, hernia pain, and abdominal pain due to parasitic infestation;

radix cyathulae: sweet and slightly bitter in taste, neutral in nature, entering liver and kidney meridians, removing blood stasis and dredging meridians.

The medicines are mutually coordinated and supported, have the effects of promoting blood circulation to remove blood stasis and dredging collaterals to relieve pain, are effectively used for treating the headache caused by blood stasis, and obtain very satisfactory beneficial technical effects through clinical tests and application, and relevant test data are as follows (taking example 1 as an example):

1 clinical data

1.1 case data are selected from 50 out-patient cases of department of encephalopathy in Henan province of China between 2018 and 2019 in 2 months, 29 male cases and 21 female cases; the age is 20-60 years, and the average age is 33.6 +/-10.2 years; the disease course lasts for 8 months to 12 years, and the average disease course is 6.5 +/-2.2 years.

Diagnostic standard the Chinese medicine diagnostic standard refers to the diagnostic standard of blood stasis headache formulated by advanced education textbook of Chinese medicine industry in China, traditional Chinese medicine internal science. The clinical manifestations are as follows: the headache is not healed for a long time, the pain is not fixed and can be like a prick, or the head has a history of trauma, and the tongue is dark purple. A thin and white tongue coating and a thready and astringent pulse.

Inclusion criteria were: 1. the Chinese medicine diagnosis standard is met; 2. the age is 18-65 years old; 3. the experiment was approved and signed an informed consent.

Exclusion criteria: (ii) those under 18 years of age or over 65 years of age; ② women in gestation period and lactation period; ③ patients with serious primary diseases such as cardiovascular diseases, pulmonary diseases, hepatic diseases, renal diseases, hemopoietic diseases, etc.; fourthly, intracranial organic lesions and diseases of the five sense organs.

2 treatment protocol the decoction of example 1 of the present invention was administered orally twice daily, 200 mL each time, for 14 consecutive days. During the treatment period, strong tea, coffee and spicy food are avoided. Statistical efficacy was observed after 14 days of treatment.

The standard of curative effect judgment basically cures: the headache disappears, no discomfort symptom exists, the tongue pulse condition returns to normal, and the tongue pulse condition does not attack after the medicine is stopped for 1 month; improvement: the headache is relieved, the attack time is shortened or the period is prolonged, and the tongue pulse condition is obviously improved; and (4) invalidation: the headache is not improved, and the pulse condition of the tongue is basically unchanged.

Statistical treatment

Through statistical treatment, 28 patients are basically cured after 50 patients are treated for 14 days, the cure rate accounts for 56%, and 21 patients are improved, and the cure rate accounts for 42%; the medicine is ineffective for 1 case, accounting for 2 percent, and the total effective rate is 98 percent.

Conclusion

Headache due to blood stasis is a common clinical symptom. Headache is caused by congenital deficiency, deficiency of both qi and blood, or deficiency of qi due to chronic disease, weakness of circulation of blood, deficiency of qi and blood stasis, and malnutrition of cerebral vessels; or headache caused by emotional disorder, anxiety, anger, liver-qi disorder, qi stagnation and blood stasis, and vein disorder; or congealing cold in the meridians and collaterals and blood stagnation; or heat blocking the meridians and collaterals and blocking qi and blood; or head trauma, blood stasis, internal stagnation, blockage of brain collaterals, obstruction of collaterals, pain, headache. Therapeutic principle is mainly to activate blood and resolve stasis, dredge collaterals and alleviate pain. The prescription is composed of salvia miltiorrhiza, rhizoma corydalis, white paeony root, peach kernel, safflower, vinegar-processed rhizoma cyperi, szechwan chinaberry fruit, medicinal cyathula root and the like. In the formula, the salvia miltiorrhiza is taken as a monarch drug, the blood circulation is promoted, the blood stasis is removed, the collateral channels are dredged and the pain is relieved, and the peach kernel, the safflower, the vinegar rhizoma cyperi and the rhizoma corydalis are taken as ministerial drugs, which help the monarch drug to promote the circulation of qi and the blood, and the collateral channels are dredge; fructus Toosendan and radix Cyathulae are used as adjuvant drugs for promoting qi circulation, promoting blood circulation, dredging collaterals and relieving pain; bai Shao is used for relieving spasm and alleviating pain. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, dredging collaterals and relieving pain by combining the medicines, and is effectively used for treating blood stasis headache. The curative effect reaches 98 percent, and no adverse reaction is found in the test period, which shows that the prescription compatibility is scientific and reasonable, the curative effect is stable, safe and reliable, and the traditional Chinese medicine is a great innovation in medicines for treating blood stasis headache.

Claims

1. The compound traditional Chinese medicine for treating blood stasis headache is characterized by comprising the following raw material medicines by weight: 15-21g of salvia miltiorrhiza, 9-15g of rhizoma corydalis, 18-30g of white paeony root, 6-8g of peach seed, 3-6g of safflower, 9-15g of vinegar rhizoma cyperi, 6-9g of szechwan chinaberry fruit and 10-15g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine surface is soaked for 30-40min, the medicine is decocted with strong fire to boil, then the medicine is decocted with slow fire for 25-30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

2. The compound traditional Chinese medicine for treating blood stasis headache according to claim 1 is characterized by comprising the following raw materials by weight: 18g of salvia miltiorrhiza, 12g of rhizoma corydalis, 24g of white paeony root, 7g of peach kernel, 4.5g of safflower, 12g of vinegar-processed rhizoma cyperi, 7.5g of szechwan chinaberry fruit and 12.5g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30-40min, the medicine is boiled by strong fire, then the medicine is decocted for 25-30min by slow fire, and the filtration is carried out to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

3. The compound traditional Chinese medicine for treating blood stasis headache according to claim 1 is characterized by comprising the following raw materials by weight: 16g of salvia miltiorrhiza, 14g of rhizoma corydalis, 19g of white paeony root, 8g of peach kernel, 4g of safflower, 14g of rhizoma cyperi with vinegar, 7g of szechwan chinaberry fruit and 14g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30 to 40min, the medicine is boiled with strong fire, then the medicine is boiled with slow fire for 25 to 30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.

4. The compound traditional Chinese medicine for treating blood stasis headache according to claim 1 is characterized by comprising the following raw materials by weight: 20g of salvia miltiorrhiza, 10g of rhizoma corydalis, 29g of white paeony root, 6g of peach kernel, 6g of safflower, 10g of rhizoma cyperi with vinegar, 9g of szechwan chinaberry fruit and 11g of medicinal cyathula root, wherein the raw material medicines are mixed together, water is added to immerse the medicine surface, the medicine is soaked for 30 to 40min, the medicine is boiled with strong fire, then the medicine is boiled with slow fire for 25 to 30min, and the medicine is filtered to obtain first liquid medicine; adding water into the residue, soaking the residue, decocting with strong fire to boil, decocting with slow fire for 25-30min, filtering to obtain second medicinal liquid, mixing the two medicinal liquids, and mixing to obtain the final product.