CN104491823A - Traditional Chinese medicine electuary for treating dysmenorrheal and preparation method of traditional Chinese medicine electuary - Google Patents

Traditional Chinese medicine electuary for treating dysmenorrheal and preparation method of traditional Chinese medicine electuary Download PDF

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CN104491823A
CN104491823A CN201510003597.XA CN201510003597A CN104491823A CN 104491823 A CN104491823 A CN 104491823A CN 201510003597 A CN201510003597 A CN 201510003597A CN 104491823 A CN104491823 A CN 104491823A
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radix
chinese medicine
allii fistulosi
dysmenorrhea
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李燚
肖明
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
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    • A61K35/56Materials from animals other than mammals
    • A61K35/616Echinodermata, e.g. starfish, sea cucumbers or sea urchins
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/52Juglandaceae (Walnut family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/61Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
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    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses Chinese medicine electuary for treating dysmenorrheal and a preparation method of the traditional Chinese medicine electuary. The traditional Chinese medicine electuary is prepared from the following raw materials: prepared rehmannia root, Chinese angelica, raw white paeony root, ligusticum wallichii, herba leonuri, rhizoma zingiberis, blue gum, fistular onion stalk, scallion root, folium artemisiae argyi, orange kernel, diaphragma juglandis, sea cucumber, radix aconiti agrestis and flos daturae, wherein the auxiliary material filling agent is brown sugar. The electuary adopts a full traditional Chinese medicine preparation, is free of great-coldness and great-coolness medicines, and does not aggravate dysmenorrheal symptom. The electuary disclosed by the invention is quick in effect taking, good in curative effect, capable of treating both symptoms and root causes, preventing and treating the cold during the menstrual period, and is an ideal drug for treating dysmenorrheal.

Description

A kind of instant particles as Chinese medicine for the treatment of dysmenorrhea and preparation method thereof
Technical field
The present invention relates to a kind of instant particles as Chinese medicine its preparation method for the treatment of dysmenorrhea, belong to technical field of traditional Chinese medicine preparation.
Background technology
Dysmenorrhea is modern female common disease, and its symptom is except tormina, also frequent with vomiting, symptom of diarrhea, brings very large misery to women.Can have side effects by Western medicine antalgica treatment dysmenorrhea, easily produce drug dependence, and cure the symptoms, not the disease.The traditional Chinese medical science thinks that the reason of dysmenorrhea is that stasis blocking is appointed in punching, and cold accumulating in meridian, causes QI and blood not smooth, menses are obstructed, so that " stagnation of QI and blood may bring about pain ", and therefore the method for conventional promoting the flow of QI in the collateral by warming the meridian, Yin Yang balancing is from conditioning human body root, treatment dysmenorrhea, but Chinese Herbs is general excessively slow, can not rapid recovery patient pain.Simultaneously, women is physical weakness before and after menstrual period, Immunoresistance is generally poor, and dysmenorrhea patients blood is obstructed, and Immunoresistance is more weak, very easily catch a cold, because Western medicine side effect is large, multiplex Chinese patent medicine of catching a cold menstrual period is treated, and the Chinese medicine for the treatment of flu mostly is cold and cool property, take the symptom that this kind of meeting increases the weight of dysmenorrhea menstrual period, affect the treatment of dysmenorrhea.
Summary of the invention
The object of the invention is to: for avoiding the side effect of Western medicine and the slow shortcoming of Chinese medicine onset, a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea is provided, by Yin Yang balancing, promoting the flow of QI in the collateral by warming the meridian, sedation-analgesia, blood stasis-eliminating and stagnation-dissipating, the method for releiving of regulating the flow of vital energy, while radical cure dysmenorrhea, effectively alleviate the symptom of stomachache, vomiting, diarrhoea.And can immunity of organisms be improved, control flu in menstrual period.
To achieve these goals, conventional granule adjuvant filler has been abandoned in technical scheme provided by the invention, use the adjuvant filler of brown sugar as this electuary instead, simultaneously, with the addition of the tonification class medicines such as Stichopus japonicus and Bulbus Allii Fistulosi, Radix Allii Fistulosi in the feed, to play sterilizing, improve immunity, to prevent curing cold.Concrete technical scheme is as follows:
The invention provides a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea, crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 3-8 part, Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Alba 8-12 part, Rhizoma Chuanxiong 8-12 part, Herba Leonuri 8-12 part, Rhizoma Zingiberis 8-12 part, Eucalyptus globulus Labill 13-18 part, Bulbus Allii Fistulosi 13-18 part, Radix Allii Fistulosi 13-18 part, Folium Artemisiae Argyi 13-18 part, Semen Citri junoris 3-8 part, Partition in Fructus Juglandis 3-8 part, Stichopus japonicus 2-5 part, Radix Aconiti Kusnezoffii 12-15 part, Flos Daturae 12-17 part, adjuvant filler is brown sugar, and its parts by weight are 60-90 part.
Further, above-mentioned a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea, preferably, crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 3 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Alba 8 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 8 parts, Rhizoma Zingiberis 8 parts, Eucalyptus globulus Labill 13 parts, Bulbus Allii Fistulosi 13 parts, Radix Allii Fistulosi 13 parts, Folium Artemisiae Argyi 13 parts, Semen Citri junoris 3 parts, Partition in Fructus Juglandis 3 parts, Stichopus japonicus 2 parts, Radix Aconiti Kusnezoffii 12 parts, Flos Daturae 12 parts, adjuvant filler is brown sugar, and its parts by weight are 60 parts.
Further, above-mentioned a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea, preferably, crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 8 parts, Radix Angelicae Sinensis 10 parts, Radix Paeoniae Alba 12 parts, Rhizoma Chuanxiong 12 parts, Herba Leonuri 12 parts, Rhizoma Zingiberis 12 parts, Eucalyptus globulus Labill 18 parts, Bulbus Allii Fistulosi 18 parts, Radix Allii Fistulosi 18 parts, Folium Artemisiae Argyi 18 parts, Semen Citri junoris 8 parts, Partition in Fructus Juglandis 8 parts, Stichopus japonicus 5 parts, Radix Aconiti Kusnezoffii 15 parts, Flos Daturae 17 parts, adjuvant filler is brown sugar, and its parts by weight are 90 parts.
Further, above-mentioned a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea, preferably, crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 6 parts, Radix Angelicae Sinensis 7 parts, Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 10 parts, Herba Leonuri 10 parts, Rhizoma Zingiberis 10 parts, Eucalyptus globulus Labill 15 parts, Bulbus Allii Fistulosi 16 parts, Radix Allii Fistulosi 15 parts, Folium Artemisiae Argyi 15 parts, Semen Citri junoris 6 parts, Partition in Fructus Juglandis 6 parts, Stichopus japonicus 4 parts, Radix Aconiti Kusnezoffii 13 parts, Flos Daturae 15 parts, adjuvant filler is brown sugar, and its parts by weight are 80 parts.
Present invention also offers the preparation method of the instant particles as Chinese medicine of described treatment dysmenorrhea, comprise the following steps:
Step 1: Bulbus Allii Fistulosi is divided into two parts by weight, it is for subsequent use that a copy of it grinds to form mud;
Step 2: Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Leonuri, Rhizoma Zingiberis, Eucalyptus globulus Labill, Radix Allii Fistulosi, Folium Artemisiae Argyi, Semen Citri junoris, Partition in Fructus Juglandis, Radix Aconiti Kusnezoffii, in Flos Daturae and step 1, remaining Bulbus Allii Fistulosi adds weight multiple is 6-10 water doubly, decocts twice, decocts 45-60 minute at every turn, filters after decocting; Merge the filtrate of twice, being concentrated into relative density is 1.10 ~ 1.15 (60 DEG C), obtain concentrated solution, add ethanol, make the mass fraction of ethanol reach 65%, stir evenly, leave standstill 24 ~ 48 hours, filter and reclaim ethanol, being concentrated into the thick paste that relative density is 1.30 ~ 1.32 (60 DEG C);
Step: 3: Stichopus japonicus is ground into powder, crosses 100 mesh sieves, obtains Stichopus japonicus powder;
Step 4: added in thick paste obtained in step 2 by Stichopus japonicus powder obtained in Bulbus Allii Fistulosi mud obtained in step 1 and step 3, stir, then add filler brown sugar, mixing, granulates, dry, to obtain final product.
The present invention is in order to treat dysmenorrhea, adopt Yin Yang balancing, promoting the flow of QI in the collateral by warming the meridian, sedation-analgesia, blood stasis-eliminating and stagnation-dissipating, regulate the flow of vital energy releive, the method for sterilizing, relieving the exterior syndrome by diaphoresis, enhancing immunity, while treating both the principal and secondary aspects of a disease dysmenorrhea, effectively anti-ly to cure cold, avoid catch a cold menstrual period taking the dysmenorrhea exacerbation of symptoms that cold and cool class coldrex causes.According to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, screen raw material of Chinese medicine by great many of experiments, refining agent method, make each efficacy of drugs produce synergism, thus reach the effect for the treatment of both the principal and secondary aspects of a disease.The crude drug chosen and effect of adjuvant be respectively: Radix Rehmanniae Preparata: nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair; Radix Angelicae Sinensis: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores; Radix Paeoniae Alba: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat; Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia; Herba Leonuri: promoting blood flow to regulate menstruation, promoting the circulation of blood dissipating blood stasis, diuresis.Cure mainly menoxenia, puerperal abdominal pain due to blood stasis, edema, dysuria, is also usually used in surgery carbuncle, and traumatic stasis such as to be had a pain the disease; Rhizoma Zingiberis: acrid in the mouth, hot in nature, warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, warming the lung to resolve fluid-retention, and for coldness and pain in the epigastrium, vomiting is had loose bowels, cold extremities faint pulse, and cold fluid-retention is breathed with cough; Eucalyptus globulus Labill: micro-pungent, the micro-hardship of taste, property is put down.Dispelling wind is antipyretic, inhibiting bacteria and diminishing inflammation, anticorrosion antipruritic.For preventing influenza, epidemic cerebrospinal meningitis, control upper respiratory tract infection, pharyngolaryngitis, bronchitis, pneumonia, Acute and chronic pyelonephritis, enteritis, dysentery, filaricide; Burn and scald is controlled in external, cellulitis, mastitis, furuncle and phyma, erysipelas, paddy-field dermatitis, skin eczema, tinea pedis, skin degerming; Bulbus Allii Fistulosi: acrid in the mouth, warm in nature, there is relieving the exterior syndrome by diaphoresis, effect of sensible yang-energy.Be mainly used in affection of exogenous wind-cold, yin-cold excess, refusing yang is in outward, and faint pulse, faints inverse, diarrhoea.The volatile oil component contained during rareripe is white has the effect of sterilizing; Radix Allii Fistulosi: hide pungent, property is put down, expelling wind and cold, removing toxic substances, and dissipating blood stasis, cures mainly headche due to wind-cold, abscess of the throat, hemorrhoid, cold injury; Folium Artemisiae Argyi: toil, temperature.Enter spleen, liver, kidney channel.To regulate the flow of vital energy blood, by cold-damp, warming the meridian, hemostasis, antiabortive.Control trusted subordinate's cold type of pain, convulsion of having loose bowels, chronic dysentery, tells nosebleed, hematochezia, menoxenia, metrorrhagia, leukorrhagia, frequent fetal movement, carbuncle and ulcer, scabies; Semen Citri junoris: bitter, flat, nontoxic, tepor.Return bladder, kidney channel, regulate the flow of vital energy, pain relieving, inducing diuresis for treating stranguria syndrome.Control hernia, gonorrhea, lumbago; Partition in Fructus Juglandis: bitter and puckery flavor, property is put down, nontoxic, spleen benefiting and strengthen kidney, and astringent therapy vital essence, controls seminal emission lingering diarrhea, gonorrhea, hematuria, incontinence of urine, metrorrhagia, leukorrhagia, dysentery, insomnia; Stichopus japonicus: cold nature, the kidney invigorating and essence nourishing, blood enriching and dryness moistening, cure mainly essence and blood loss, weak labor is timid, sexual impotence, nocturnal emission, dryness of the intestine constipation, and cough due to deficiency of the lung spits blood, discharging fresh blood stool, traumatic hemorrhage, and long-term taking is improved effect of immunity; Radix Aconiti Kusnezoffii: GUIXIN, liver,kidney,spleen warp, expelling wind and removing dampness, antalgic; Flos Daturae: smooth-going cough-relieving, narcotic analgesic, spasmolytic is only jerked; Brown sugar: sweet, gentle, nontoxic.Enter liver, spleen.Effect: profit cardiopulmonary, and in help spleen, slow irritability, alcoholic intoxication, enriches blood, removing blood stasis with potent drugs.
Wherein, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Leonuri, Folium Artemisiae Argyi are monarch drug, play promoting flow of qi by warming channel Yin Yang balancing, regulating menstruation and nourishing blood; Rhizoma Zingiberis is hot in nature, dispelling cold by warming the meridian, monarch drug recuperating depleted YANG can be assisted to promote blood circulation as ministerial drug, and the effect simultaneously with treatment vomiting and diarrhoea can effective relieving dysmenorrhea symptom; Semen Citri junoris is regulated the flow of vital energy, Partition in Fructus Juglandis spleen benefiting and strengthen kidney, can promote the effect of monarch drug conditioning human body as accessory drugs, strengthen drug effect, meanwhile, Semen Citri junoris also answers effect of pain relieving, itself and Radix Aconiti Kusnezoffii, Flos Daturae as accessory drugs synergism, can while the effect of enhancing monarch drug rapid recovery colic symptoms; Eucalyptus globulus Labill, Bulbus Allii Fistulosi, Radix Allii Fistulosi, Stichopus japonicus all have the anti-effect cured cold as accessory drugs, Bulbus Allii Fistulosi and Radix Allii Fistulosi have dispel cold, the effect of relieving the exterior syndrome by diaphoresis, anemofrigid cold can be prevented and treated, white and the Eucalyptus globulus Labill of rareripe also has the effect of sterilizing, can prevent bacillary flu, Stichopus japonicus and the tonification such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata class medicine improve self-resistance by vital base and primordial QI consolidating and play the anti-effect cured cold; Meanwhile, adjuvant filler brown sugar also has the effect of removing blood stasis with potent drugs of enriching blood, itself and Rhizoma Zingiberis and Bulbus Allii Fistulosi, Radix Allii Fistulosi synergism can strengthen dispel the wind dispel cold, the effect of relieving the exterior syndrome by diaphoresis, effective relieving dysmenorrhea symptom, anti-ly to cure cold; Crude drug selected by this electuary is all without Great Cold, large medicine of a cold nature thing, but adopting tonification class medicine, sterilization class medicine and cold relieving to induce sweat, class medicine is anti-while treatment dysmenorrhea cures cold, effectively prevent menstruation infection flu and take cool nature medicine thing and the dysmenorrhea exacerbation of symptoms that causes.All medicines share above, and have and well treat dysmenorrhea, anti-effect cured cold, and all medicines are nursed one's health mutually, little to body harmful effect, clinical practice is safer.
Beneficial effect of the present invention is: the invention provides a kind of instant particles as Chinese medicine for the treatment of dysmenorrhea, effectively prevent Western medicine side effect, drug dependence is strong, and the defect of the shortcoming that Chinese medicine preparation onset is slow, the course for the treatment of is long.This electuary has advantage that is rapid-action, good effect treating both the principal and secondary aspects of a disease, adopts the analgesia class medicine such as Radix Aconiti Kusnezoffii, Flos Daturae and the emesis such as Rhizoma Zingiberis, Bulbus Allii Fistulosi antidiarrheal class medicine, the stomachache of quick effectively relieving dysmenorrhea, vomiting, symptom of diarrhea; Adopt the tonification class medicines such as Stichopus japonicus to regulate body, promoting the flow of QI in the collateral by warming the meridian comprehensively, dispel cold, Yin Yang balancing, vital base and primordial QI consolidating, fundamentally treat dysmenorrhea, improve patient's autoimmunity., to put down in conjunction with tonification class medicine, property or flu in menstrual period effectively prevented and treated by sterilization class medicine warm in nature and the cold relieving class medicine that induces sweat meanwhile, avoid taking cold and cool property coldrex menstrual period and cause dysmenorrhea exacerbation of symptoms, affect therapeutic effect.This electuary chooses brown sugar as filler, takes full advantage of brown sugar and to enrich blood the effect of removing blood stasis with potent drugs, enhance the effect of crude drug effective ingredient.Electuary instant effect of the present invention, good effect, treating both the principal and secondary aspects of a disease and can prevent and treat menstrual period flu, be the medicine of desirable treatment dysmenorrhea.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only should can not limit the present invention described in detail in claims yet for illustration of the present invention.
Embodiment 1 prepares the instant particles as Chinese medicine for the treatment of dysmenorrhea
Formula is: Radix Rehmanniae Preparata 30 grams, Radix Angelicae Sinensis 50 grams, Radix Paeoniae Alba 80 grams, Rhizoma Chuanxiong 80 grams, Herba Leonuri 80 grams, Rhizoma Zingiberis 80 grams, Eucalyptus globulus Labill 130 grams, Bulbus Allii Fistulosi 130 grams, Radix Allii Fistulosi 130 grams, Folium Artemisiae Argyi 130 grams, Semen Citri junoris 30 grams, Partition in Fructus Juglandis 30 grams, Stichopus japonicus 20 grams, Radix Aconiti Kusnezoffii 120 grams, Flos Daturae 120 grams, 600 grams, brown sugar.
Compound method is:
Step 1: Bulbus Allii Fistulosi is divided into two parts by weight, it is for subsequent use that a copy of it grinds to form mud;
Step 2: Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Leonuri, Rhizoma Zingiberis, Eucalyptus globulus Labill, Radix Allii Fistulosi, Folium Artemisiae Argyi, Semen Citri junoris, Partition in Fructus Juglandis, Radix Aconiti Kusnezoffii, in Flos Daturae and step 1, remaining Bulbus Allii Fistulosi adds the water that weight multiple is 6 times, decocts twice, decocts 60 minutes at every turn, filters after decocting; Merge the filtrate of twice, being concentrated into relative density is 1.15 (60 DEG C), obtains concentrated solution, add ethanol, make the mass fraction of ethanol reach 65%, stir evenly, when leaving standstill 48, filter and reclaim ethanol, being concentrated into the thick paste that relative density is 1.30 (60 DEG C);
Step: 3: Stichopus japonicus is ground into powder, crosses 100 mesh sieves, obtains Stichopus japonicus powder;
Step 4: added in thick paste obtained in step 2 by Stichopus japonicus powder obtained in Bulbus Allii Fistulosi mud obtained in step 1 and step 3, stir, then add filler brown sugar, mixing, granulates, dry, to obtain final product.
During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.
Embodiment 2 prepares the instant particles as Chinese medicine for the treatment of dysmenorrhea
Formula is: Radix Rehmanniae Preparata 80 grams, Radix Angelicae Sinensis 100 grams, Radix Paeoniae Alba 120 grams, Rhizoma Chuanxiong 120 grams, Herba Leonuri 120 grams, Rhizoma Zingiberis 120 grams, Eucalyptus globulus Labill 180 grams, Bulbus Allii Fistulosi 180 grams, Radix Allii Fistulosi 180 grams, Folium Artemisiae Argyi 180 grams, Semen Citri junoris 80 grams, Partition in Fructus Juglandis 80 grams, Stichopus japonicus 50 grams, Radix Aconiti Kusnezoffii 150 grams, Flos Daturae 170 grams, 900 grams, brown sugar.
Collocation method is similar to embodiment 1, and difference is: add the water that weight multiple is 10 times in step 3, decoct twice, each decoction 45 minutes, filters after decocting; Merge the filtrate of twice, being concentrated into relative density is 1.10 (60 DEG C), obtains concentrated solution, adding ethanol makes the mass fraction of ethanol reach 65%, stirs evenly, and leaves standstill 24 hours, filter and reclaim ethanol, being concentrated into the thick paste that relative density is 1.32 (60 DEG C);
During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.
Embodiment 3 prepares the instant particles as Chinese medicine for the treatment of dysmenorrhea
Formula is: Radix Rehmanniae Preparata 60 grams, Radix Angelicae Sinensis 70 grams, Radix Paeoniae Alba 100 grams, Rhizoma Chuanxiong 100 grams, Herba Leonuri 100 grams, Rhizoma Zingiberis 100 grams, Eucalyptus globulus Labill 150 grams, Bulbus Allii Fistulosi 160 grams, Radix Allii Fistulosi 150 grams, Folium Artemisiae Argyi 150 grams, Semen Citri junoris 60 grams, Partition in Fructus Juglandis 60 grams, Stichopus japonicus 40 grams, Radix Aconiti Kusnezoffii 130 grams, Flos Daturae 150 grams, 800 grams, brown sugar.
Collocation method is similar to embodiment 1, and difference is: add the water that weight multiple is 8 times in step 3, decoct twice, each decoction 50 minutes, filters after decocting; Merge the filtrate of twice, being concentrated into relative density is 1.13 (60 DEG C), obtains concentrated solution, adding ethanol makes the mass fraction of ethanol reach 65%, stirs evenly, and leaves standstill 36 hours, filter and reclaim ethanol, being concentrated into the thick paste that relative density is 1.31 (60 DEG C);
During treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily.
Embodiment 4 clinical experimental study
Give the instant particles as Chinese medicine of any one of the embodiment of the present invention 1 to 3, during treatment, ante cibum, boiling water was taken after mixing it with water, each 15 grams, a twice-daily, and January was 1 course for the treatment of, observe the curative effect after serveing on 3 courses for the treatment of.
Random selecting 100 dysmenorrhea patients, in age 14-48 year, average 31 years old, wherein, 92 people were primary dysmenorrhea patient, and 8 people are secondary dysmenorrhea patient, and 100 patients all have colic symptoms, and wherein 73 people have nausea and vomiting symptom, and 26 people have symptom of diarrhea; In treatment dysmenorrhea, take 3 courses for the treatment of of this electuary, 15 people's recoveries from illness, dysmenorrhea symptom is eliminated, and after drug withdrawal in 6 months without recurrence; 40 people have significant curative effect, and dysmenorrhea symptom is eliminated substantially, but after drug withdrawal in 6 months symptom have and repeatedly need to continue to take medicine; 42 people are effective in cure, and dysmenorrhea symptom is alleviated to some extent or part is eliminated, and need continue medication treatment; 3 people's inefficacies, total effective rate 97%.The patient of 100 these Chongji for Treatments of taking medicine is all without aggravation symptom.
Clinical exemplary embodiments:
1, Xiao, 18 years old, female, primary dysmenorrhea, abdominal pain in menstruation, and with nausea and vomiting symptom, the instant particles as Chinese medicine taking embodiment 1 is of that month, and nausea and vomiting symptom is eliminated, stomachache is alleviated to some extent, and after taking medicine 3 months continuously, dysmenorrhea symptom is eliminated, and drug withdrawal was not recurred in 6 months.
2, together certain, 45 years old, female, secondary dysmenorrhea, menstrual period, tormina, with vomiting and diarrhoea symptom, need take Western medicine analgesic alleviating pain, take the of that month vomiting and diarrhoea remission of instant particles as Chinese medicine of embodiment 2, colic symptoms is obviously alleviated, and analgesic of can stopping using, after taking medicine 3 months continuously, vomiting and diarrhoea symptom is eliminated, and colic symptoms is obviously alleviated not to be needed to take analgesic again.
3, Xue, 32 years old, female, primary dysmenorrhea, menstrual period, tormina, relied on analgesic for a long time, and the of that month colic symptoms of instant particles as Chinese medicine taking embodiment 3 is alleviated to some extent, after taking medicine 3 months continuously, colic symptoms disappears, and does not need to take analgesic again, drug withdrawal 2 months disease relapses, recovery from illness after continuing to take medicine 3 months, drug withdrawal 6 months is without recurrence.
Result shows, the instant particles as Chinese medicine for the treatment of dysmenorrhea of the present invention, can rapid recovery dysmenorrhea symptom, treating both the principal and secondary aspects of a disease dysmenorrhea, and effectively can prevent and treat flu in menstrual period, is the medicine of desirable treatment dysmenorrhea.
Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.

Claims (5)

1. treat the instant particles as Chinese medicine of dysmenorrhea for one kind, it is characterized in that: crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 3-8 part, Radix Angelicae Sinensis 5-10 part, Radix Paeoniae Alba 8-12 part, Rhizoma Chuanxiong 8-12 part, Herba Leonuri 8-12 part, Rhizoma Zingiberis 8-12 part, Eucalyptus globulus Labill 13-18 part, Bulbus Allii Fistulosi 13-18 part, Radix Allii Fistulosi 13-18 part, Folium Artemisiae Argyi 13-18 part, Semen Citri junoris 3-8 part, Partition in Fructus Juglandis 3-8 part, Stichopus japonicus 2-5 part, Radix Aconiti Kusnezoffii 12-15 part, Flos Daturae 12-17 part, adjuvant filler is brown sugar, and its parts by weight are 60-90 part.
2. the instant particles as Chinese medicine for the treatment of dysmenorrhea as claimed in claim 1, is characterized in that: crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 3 parts, Radix Angelicae Sinensis 5 parts, Radix Paeoniae Alba 8 parts, Rhizoma Chuanxiong 8 parts, Herba Leonuri 8 parts, Rhizoma Zingiberis 8 parts, Eucalyptus globulus Labill 13 parts, Bulbus Allii Fistulosi 13 parts, Radix Allii Fistulosi 13 parts, Folium Artemisiae Argyi 13 parts, Semen Citri junoris 3 parts, Partition in Fructus Juglandis 3 parts, Stichopus japonicus 2 parts, Radix Aconiti Kusnezoffii 12 parts, Flos Daturae 12 parts, adjuvant filler is brown sugar, and its parts by weight are 60 parts.
3. the instant particles as Chinese medicine for the treatment of dysmenorrhea as claimed in claim 1, is characterized in that: crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 8 parts, Radix Angelicae Sinensis 10 parts, Radix Paeoniae Alba 12 parts, Rhizoma Chuanxiong 12 parts, Herba Leonuri 12 parts, Rhizoma Zingiberis 12 parts, Eucalyptus globulus Labill 18 parts, Bulbus Allii Fistulosi 18 parts, Radix Allii Fistulosi 18 parts, Folium Artemisiae Argyi 18 parts, Semen Citri junoris 8 parts, Partition in Fructus Juglandis 8 parts, Stichopus japonicus 5 parts, Radix Aconiti Kusnezoffii 15 parts, Flos Daturae 17 parts, adjuvant filler is brown sugar, and its parts by weight are 90 parts.
4. the instant particles as Chinese medicine for the treatment of dysmenorrhea as claimed in claim 1, is characterized in that: crude drug composition and the parts by weight of making described electuary effective ingredient are: Radix Rehmanniae Preparata 6 parts, Radix Angelicae Sinensis 7 parts, Radix Paeoniae Alba 10 parts, Rhizoma Chuanxiong 10 parts, Herba Leonuri 10 parts, Rhizoma Zingiberis 10 parts, Eucalyptus globulus Labill 15 parts, Bulbus Allii Fistulosi 16 parts, Radix Allii Fistulosi 15 parts, Folium Artemisiae Argyi 15 parts, Semen Citri junoris 6 parts, Partition in Fructus Juglandis 6 parts, Stichopus japonicus 4 parts, Radix Aconiti Kusnezoffii 13 parts, Flos Daturae 15 parts, adjuvant filler is brown sugar, and its parts by weight are 80 parts.
5. the preparation method of the instant particles as Chinese medicine for the treatment of dysmenorrhea according to claim 1, is characterized in that: comprise the following steps:
Step 1: Bulbus Allii Fistulosi is divided into two parts by weight, it is for subsequent use that a copy of it grinds to form mud;
Step 2: Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba, Rhizoma Chuanxiong, Herba Leonuri, Rhizoma Zingiberis, Eucalyptus globulus Labill, Radix Allii Fistulosi, Folium Artemisiae Argyi, Semen Citri junoris, Partition in Fructus Juglandis, Radix Aconiti Kusnezoffii, in Flos Daturae and step 1, remaining Bulbus Allii Fistulosi adds weight multiple is 6-10 water doubly, decocts twice, decocts 45-60 minute at every turn, filters after decocting; Merge the filtrate of twice, being concentrated into relative density is 1.10 ~ 1.15 (60 DEG C), obtain concentrated solution, add ethanol, make the mass fraction of ethanol reach 65%, stir evenly, leave standstill 24 ~ 48 hours, filter and reclaim ethanol, being concentrated into the thick paste that relative density is 1.30 ~ 1.32 (60 DEG C);
Step 3: Stichopus japonicus is ground into powder, crosses 100 mesh sieves, obtains Stichopus japonicus powder;
Step 4: added in thick paste obtained in step 2 by Stichopus japonicus powder obtained in Bulbus Allii Fistulosi mud obtained in step 1 and step 3, stir, then add filler brown sugar, mixing, granulates, dry, to obtain final product.
CN201510003597.XA 2015-01-06 2015-01-06 Traditional Chinese medicine electuary for treating dysmenorrheal and preparation method of traditional Chinese medicine electuary Pending CN104491823A (en)

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