CN111991527A - Foot medicated bath formula and preparation process thereof - Google Patents

Foot medicated bath formula and preparation process thereof Download PDF

Info

Publication number
CN111991527A
CN111991527A CN202010970165.7A CN202010970165A CN111991527A CN 111991527 A CN111991527 A CN 111991527A CN 202010970165 A CN202010970165 A CN 202010970165A CN 111991527 A CN111991527 A CN 111991527A
Authority
CN
China
Prior art keywords
parts
root
foot
weight
bath formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010970165.7A
Other languages
Chinese (zh)
Inventor
王艳萍
李长慧
李雪微
于绍卉
程巍
王南竹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affiliated Hospital Of Changchun University Of Chinese Medicine (jilin Provincial Hospital Of Tcm)
Original Assignee
Affiliated Hospital Of Changchun University Of Chinese Medicine (jilin Provincial Hospital Of Tcm)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affiliated Hospital Of Changchun University Of Chinese Medicine (jilin Provincial Hospital Of Tcm) filed Critical Affiliated Hospital Of Changchun University Of Chinese Medicine (jilin Provincial Hospital Of Tcm)
Priority to CN202010970165.7A priority Critical patent/CN111991527A/en
Publication of CN111991527A publication Critical patent/CN111991527A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/904—Stemonaceae (Stemona family), e.g. croomia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses a foot medicinal bath formula and a preparation process thereof, wherein the foot medicinal bath formula is prepared from the following raw materials in parts by weight: 20-30 parts of teasel root, 10-20 parts of eucommia bark, 15-25 parts of epimedium, 45-55 parts of radix stemonae, 45-55 parts of radix sophorae flavescentis, 10-20 parts of fennel, 5-15 parts of liquorice, 5-15 parts of earthworm and 10-20 parts of polygonatum. The foot bath formula reduces the toxicity of the medicaments and improves the medicament effect by reasonably matching monarch, minister, assistant and guide medicaments, and the formula can be used for treating common gynecological diseases which are difficult to cure for a long time, such as gynecological inflammation, cold womb, cold limbs and the like. The invention also provides two preparation processes of the foot medicated bath formula, wherein one preparation process produces powder, and the other preparation process produces liquid medicine, and the two preparation processes can obviously improve the exertion of the drug effect and promote the absorption of the drug.

Description

Foot medicated bath formula and preparation process thereof
Technical Field
The invention relates to the technical field of medicines, in particular to a formula of a foot bath or a whole body medicated bath and a preparation process thereof.
Background
The gynecological diseases are common and frequently encountered diseases of women, and mainly comprise vulvar diseases, vaginal diseases, uterine diseases, fallopian tube diseases, ovarian diseases and the like. However, many people lack due knowledge of gynecological diseases, lack of health care of the body, and various bad living habits and habits, so that the physiological health of the people is gradually improved, some female diseases are entangled and cannot be cured for a long time, and great inconvenience is brought to normal life and work. For gynecological diseases with repeated attack and long-term treatment, if an oral drug therapy method is adopted for a long time, drug toxins can cause great harm to human bodies under the condition of long-term accumulation, so that other serious diseases such as cancers are caused.
The foot bath or the whole body medicated bath enables active ingredients of the medicine to act on a human body through blood circulation and metabolism by the principle of transdermal absorption of traditional Chinese medicines, and discharges toxin out of the body by combining self regulation of the human body. The foot bath has the effects of inhibiting bacterial infection; promoting blood circulation, accelerating metabolism and dredging obstruction; the curative effects of clearing heat and removing toxicity, dispelling wind and arresting itching, and relieving swelling and pain originate in Huangdi's inner meridian. The foot medicated bath has the obvious advantages of reducing the absorption of toxin in the medicine by human body, and further treating the recurrent or intractable gynecological diseases by adopting the foot medicated bath mode for a long time. In addition, the foot medicated bath has the defects that the absorption rate of macromolecular drug molecules is low due to the principle that traditional Chinese medicines are absorbed through skin, so that if the formula of the foot medicated bath drug is not treated by a special means to promote the absorption rate of the drug in the medicated bath process, the effective time of the foot medicated bath is slow, the curative effect is reduced, and the waste of the drug is caused.
Disclosure of Invention
In view of the above, one of the objectives of the present invention is to provide a foot bath formula for adjuvant therapy of some common and intractable gynecological diseases such as gynecological inflammation, cold womb, cold hands, feet and limbs.
In order to achieve the purpose, the invention adopts the technical scheme that:
the invention relates to a foot bath formula which is prepared from the following raw materials in parts by weight: 20-30 parts of teasel root, 10-20 parts of eucommia bark, 15-25 parts of epimedium, 45-55 parts of radix stemonae, 45-55 parts of radix sophorae flavescentis, 10-20 parts of fennel, 5-15 parts of liquorice, 5-15 parts of earthworm and 10-20 parts of polygonatum odoratum, wherein the radix stemonae is preferably stemona vine.
The efficacy and the function of each medicine component in the formula are as follows:
dipsacus asperoides, also known as Hirschner asperoides, is the dried root of Dipsacus asperoides of the family Dipsacaceae, a perennial herb. The Yunnan herbal medicine: nourishing liver, strengthening tendons and bones, fixing meridians, relieving soreness of meridians and bones, preventing miscarriage, treating leucorrhea, promoting hematopoiesis, removing blood stasis, arresting abortion, relieving cough and hemoptysis, and treating red, white and turbid urine.
The dipsacus root extract, the total alkaloids and the volatile oil have obvious effect of inhibiting contraction of the uterus of a non-pregnant or pregnant mouse. Most of toxicity to patients and fetuses can be eliminated through foot bath, so that the medicine becomes a good medicine for treating dysmenorrhea; dipsacus asperoides has the effects of nourishing liver and kidney and strengthening bones and muscles, is used together with eucommia ulmoides to treat lumbar muscle strain, osteoporosis, hyperosteogeny, osteonecrosis and trauma sequelae, and is characterized by liver and kidney deficiency, soreness and pain of waist and back caused by rheumatism and blood vessel retardation, soreness and cold of legs and knees, and preference for knocking and warming, and can strengthen physique and improve symptoms commonly.
The dipsacus root volatile oil has strong bacteriostatic ability on staphylococcus aureus, and animal experiments show that the dipsacus root volatile oil has obvious physiological activity.
Du Zhong is sweet and warm in nature and flavor. It enters liver and kidney meridians. The efficacy is as follows: tonify liver and kidney, strengthen tendons and bones, prevent abortion. The main functions are as follows: can be used for treating soreness of waist and knees, debility of lower limbs, sexual impotence, and frequent micturition due to deficiency of liver and kidney. It can tonify liver and kidney, strengthen tendons and bones, warm lower energizer.
Epimedium herb, pungent in flavor, sweet in flavor and warm in nature. It enters liver and kidney meridians. Has the functions of invigorating kidney yang, strengthening bones and muscles and eliminating rheumatism. Herba Epimedii can be used for treating infertility due to cold womb. It also can be used for treating deficiency of liver and kidney, rheumatism, chronic arthralgia, and dysbasia.
Radix Stemonae, sweet and bitter in taste, slightly warm in nature, enters lung meridian, and has effects of moistening lung, relieving cough, and killing parasite. Radix Stemonae contains various alkaloids, such as stemonine, and protostemonine, which have antibacterial effect on most pathogenic bacteria and dermatophytes, and can be used for treating scabies and eczema. The radix stemonae is not processed by decoction pieces, and if the radix stemonae is directly taken orally, alkaloid contained in the radix stemonae has certain toxicity to human bodies, and the bacteriostasis of the radix stemonae is mainly acted by the alkaloid, so that the inventor finds that the radix stemonae is particularly suitable for being used as a monarch drug in a foot bath formula.
Ku Shen is bitter in taste and cold in nature. Has the functions of clearing heat, drying dampness, killing parasites and promoting urination. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis. The matrine is the main component of the sophora flavescens gel medicine, has the functions of antibiosis and antiphlogosis, and is mainly used for treating gynecological diseases such as cervical erosion, trichomonas vaginitis, mycotic vaginitis and other gynecological chronic inflammations.
The side effects of the sophora flavescens are mainly that the sophora flavescens is relatively cold and can cause damage to the spleen and stomach of a human body, and long-time application of the sophora flavescens can cause gastritis, even dysfunction, dyspepsia, diarrhea and the like of the digestive tract. In addition, part of roots and seeds of the sophora flavescens are toxic, and the sophora flavescens can be poisoned in the application process, mainly has high nervous toxicity, and has the disadvantages of salivation, dyspnea, arrhythmia, unstable gait, severe convulsion and even respiratory failure inhibition to cause clinical death. In view of the side effects of sophora flavescens, if sophora flavescens is not processed by decoction pieces, oral administration has certain toxicity to human bodies, and the bacteriostatic action of sophora flavescens is mainly acted by total matrines, so the inventor of the application finds that sophora flavescens is particularly suitable to be used as a monarch drug in the prescription of the foot medicated bath of the application.
Fennel, pungent in flavor and warm in nature, enters liver, kidney, spleen and stomach meridians. According to pharmacological research, the fennel has the effects of dispelling cold, relieving pain, regulating qi and harmonizing stomach, and is clinically used for treating symptoms such as cold hernia and abdominal pain, testicular tenesmus, female dysmenorrheal, lower abdominal psychroalgia, abdominal distending pain, anorexia, vomiting and diarrhea and the like.
Licorice root, radix Glycyrrhizae is sweet in flavor and neutral in nature. They enter heart, lung, spleen and stomach meridians. Has the effects of tonifying qi and strengthening the middle warmer, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing drug properties. It can be used for treating spleen qi deficiency, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limbs spasm, pain, toxic heat, pyocutaneous disease, sore throat, and drug and food poisoning; relieve the toxicity and the severity of the drugs. In addition, the external application of the liquorice can treat pruritus due to yin dampness, so the liquorice can be used as an adjuvant drug and also used as an adjuvant drug.
Earthworm, also known as earthworm, has the efficacy of clearing and activating the channels and collaterals and is used for treating arthralgia syndrome and hemiplegia. Lumbricus can be used for treating meridian obstruction, blood vessel disorder, and adverse limb and joint syndrome caused by various reasons. It is used as a guiding drug in the recipe, and plays a role in inducing menstruation.
The polygonatum odoratum is called as venetian and girl, has mild nature, sweet taste, is soft, moist and edible, is used for removing wind-heat damp toxin and treating yin deficiency and body feeling cold and wind-warm disease, is used as a component in the foot bath formula, and can play a role in strengthening physique and preventing cold of middle-aged and old people.
Preferably, the foot bath formula is prepared from the following raw materials in parts by weight: 25 parts of teasel root, 15 parts of eucommia bark, 20 parts of epimedium herb, 50 parts of stemona root, 50 parts of lightyellow sophora root, 15 parts of common fennel fruit, 10 parts of liquorice, 10 parts of earthworm, 15 parts of fragrant solomonseal rhizome and 10 parts of starch. The effect of the starch in the formula is as follows: during the pharmaceutical process, the starch can play a role in locking the teasel root volatile oil and other volatile micromolecule medicine active ingredients when being gelatinized at high temperature, and the medicine effect of the foot bath formula can be obviously improved by adding the starch.
Preferably, the foot bath formula is prepared from the following raw materials in parts by weight: 25 parts of teasel root, 15 parts of eucommia bark, 20 parts of epimedium herb, 50 parts of stemona root, 50 parts of lightyellow sophora root, 15 parts of common fennel fruit, 10 parts of liquorice, 10 parts of earthworm, 15 parts of fragrant solomonseal rhizome and 10 parts of white vinegar with the acetic acid content of 3.5g/100 ml. The preferred formulation is suitable for packaging as a liquid medicament. The acetic acid in the formula can dissolve beneficial medicinal components in the formula, and can accelerate the release speed of the medicament in water and promote the absorption of human skin to the medicament in the foot medicinal bath process.
The invention also aims to provide a preparation process of the foot bath formula, and the medicament produced by the preparation process can maximally retain beneficial components which are easily absorbed by human skin in the medicament, especially volatile small molecule beneficial components.
The preparation process of the foot bath formula comprises the following steps:
s1) taking corresponding parts by weight of teasel root, eucommia bark, epimedium herb, sessile stemona root, lightyellow sophora root, common fennel fruit, liquoric root, earthworm and fragrant solomonseal rhizome, and crushing the mixture in a crusher;
s2) mixing the crushed particles with starch in corresponding weight parts, then putting the mixture into a sealed high-pressure frying pan for stir-frying, keeping the sealed state after stir-frying, and slowly cooling to below 10 ℃; volatile oil volatile substance content can show to reduce under the high temperature in the medicine, adopt sealed pharmacy's mode to make chinese teasel root volatile oil etc. volatile beneficial drug composition will distribute in the inside of sealed frying pan, through starch gelatinization under the high temperature, volatile oil can form the inclusion compound with starch, distribute the volatile oil inside the frying pan promptly and can be contained in the starch helicoid, difficult leaching from the helicoid, when the lavipeditum, the gelatinization starch that contains volatile oil can be dissolved in aqueous rapidly, the dissolving rate of medicine is accelerated, if the foot bath in-process is further supplementary to add amylase, can make volatile oil release from starch completely, thereby can show improvement drug effect.
S3) taking the medicinal powder cooled to below 10 ℃ in the step 2 out of a frying pan, mixing the medicinal powder with a proper amount of amylase, and then packaging in bags to obtain the foot bath formula powder. Before packaging the medicinal powder, a proper amount of amylase is mixed and added into the medicinal powder, and the amylase can decompose starch in an aqueous solution, so that the small molecular medicinal components wrapped by the starch can be fully released into water.
The medicament produced by the preparation process can promote the absorption rate of human bodies to the medicament in the medicinal bath process, so that the medicinal bath for feet takes effect quickly, and simultaneously avoids the waste of the medicament.
The preparation process of the foot bath formula comprises the following steps:
s1) taking corresponding parts by weight of teasel root, eucommia bark, epimedium herb, sessile stemona root, lightyellow sophora root, common fennel fruit, liquoric root, earthworm and fragrant solomonseal rhizome, and crushing the mixture in a crusher;
s2) putting the crushed particles into a medicine boiler for high-pressure cooking, and filtering the cooked medicine liquid to obtain filtrate;
s3) mixing the filtrate obtained in the step 2 with white vinegar in corresponding parts by weight, and then packaging in bags to obtain the foot bath formula liquid medicine.
The invention has the beneficial effects that:
1) the prescription of the foot medicated bath reduces the toxicity of the medicaments by reasonably configuring monarch, minister, assistant and guide medicaments in the prescription, obviously improves the medicinal effect, can be used for foot bath or whole body medicated bath, can be used for treating common gynecological diseases which are difficult to cure for a long time, such as gynecological inflammation, cold womb, cold limbs and limbs, and the like, and solves the problems of difficult cure for a long time and medicament toxicity accumulation caused by treating the gynecological diseases by oral medicaments in the past.
2) The invention also provides two preparation processes of the foot medicated bath formula, wherein one preparation process produces powder, and the other preparation process produces liquid medicine, and the two preparation processes can obviously improve the exertion of the drug effect and promote the absorption of the drug.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be further described in detail with reference to specific embodiments.
EXAMPLE 1 foot bath formulation
The foot bath formula in the embodiment is prepared from the following raw materials: 20g of teasel root, 10g of eucommia bark, 15g of epimedium herb, 45g of stemona root, 45g of lightyellow sophora root, 10g of common fennel fruit, 5g of liquorice, 5g of earthworm and 10g of fragrant solomonseal rhizome.
EXAMPLE 2 foot bath formulation
The foot bath formula in the embodiment is prepared from the following raw materials: 30g of teasel root, 20g of eucommia bark, 25g of epimedium herb, 55g of stemona root, 55g of lightyellow sophora root, 20g of common fennel fruit, 15g of liquorice, 15g of earthworm and 20g of fragrant solomonseal rhizome.
EXAMPLE 3 foot bath formulation
The foot bath formula in the embodiment is prepared from the following raw materials: 25g of teasel root, 15g of eucommia bark, 20g of epimedium herb, 50g of stemona root, 50g of lightyellow sophora root, 15g of common fennel fruit, 10g of liquorice, 10g of earthworm, 15g of fragrant solomonseal rhizome and 10g of starch.
EXAMPLE 4 foot bath formulation
The foot bath formula in the embodiment is prepared from the following raw materials: 25g of teasel root, 15g of eucommia bark, 20g of epimedium herb, 50g of stemona root, 50g of lightyellow sophora root, 15g of common fennel fruit, 10g of liquorice, 10g of earthworm, 15g of fragrant solomonseal rhizome and 10g of white vinegar with the acetic acid content of 3.5g/100 ml.
EXAMPLE 5 preparation of foot bath formula
The preparation process of the foot bath formula in the embodiment comprises the following steps:
s1) taking the teasel roots, the eucommia ulmoides, the epimedium herbs, the sessile stemona roots, the lightyellow sophora roots, the fennel, the liquorice, the earthworms and the fragrant solomonseal rhizome with corresponding weight fractions, placing the materials in a material buffer room, then turning on an ultraviolet lamp, and irradiating for 20 minutes for pretreatment; mixing pretreated radix Dipsaci, Eucommiae cortex, herba Epimedii, radix Stemonae, radix Sophorae Flavescentis, fructus Foeniculi, Glycyrrhrizae radix, Lumbricus, and rhizoma Polygonati Odorati in a pulverizer, and pulverizing;
s2) mixing the crushed particles with starch in corresponding weight parts, then putting the mixture into a sealed high-pressure frying pan, stir-frying until the surface is yellowish, keeping the sealed state after stir-frying, putting the frying pan into a low-temperature cold store for cooling, and slowly cooling to below 10 ℃, preferably to below 0 ℃;
s3) taking the cooled medicinal powder in the step 2 out of a frying pan, mixing and adding a proper amount of amylase into the medicinal powder, wherein the amylase content in the mixed medicinal powder accounts for 5% by weight, and packaging the obtained powder particles into bags by using a fixed weight packaging machine, wherein the net content of each bag is 25 g.
The powder of example 5 is more suitable for foot bath.
EXAMPLE 6 preparation of foot bath formula
The preparation process of the foot bath formula in the embodiment comprises the following steps:
s1) taking the teasel roots, the eucommia ulmoides, the epimedium herbs, the sessile stemona roots, the lightyellow sophora roots, the fennel, the liquorice, the earthworms and the fragrant solomonseal rhizome with corresponding weight fractions, placing the materials in a material buffer room, then turning on an ultraviolet lamp, and irradiating for 20 minutes for pretreatment; mixing pretreated radix Dipsaci, Eucommiae cortex, herba Epimedii, radix Stemonae, radix Sophorae Flavescentis, fructus Foeniculi, Glycyrrhrizae radix, Lumbricus, and rhizoma Polygonati Odorati in a pulverizer, and pulverizing;
s2) putting the mixed and crushed particles into a medicine boiler for high-pressure cooking at 90-100 ℃ for 1 hour, naturally cooling to room temperature, and filtering the cooked liquid medicine to obtain filtrate;
s3) mixing the filtrate obtained in the step 2 with white vinegar in corresponding parts by weight, wherein the content of the mixed white vinegar is 10% by weight, and then packaging the mixture in bags by a filling machine, wherein the dosage of each bag is 50 g.
The liquid medicine in example 6 is filtered, and therefore is suitable for use in a general medicated bath as well as a foot bath.
The above description is intended to describe in detail the preferred embodiments of the present invention, and the embodiments are not intended to limit the scope of the claims of the present invention, and all equivalent changes and modifications made within the technical spirit of the present invention should fall within the scope of the claims of the present invention.

Claims (7)

1. The foot bath formula is characterized by being prepared from the following raw materials in parts by weight: 20-30 parts of teasel root, 10-20 parts of eucommia bark, 15-25 parts of epimedium, 45-55 parts of radix stemonae, 45-55 parts of radix sophorae flavescentis, 10-20 parts of fennel, 5-15 parts of liquorice, 5-15 parts of earthworm and 10-20 parts of polygonatum.
2. The foot bath formula according to claim 1, which is prepared from the following raw materials in parts by weight: 25 parts of teasel root, 15 parts of eucommia bark, 20 parts of epimedium herb, 50 parts of stemona root, 50 parts of lightyellow sophora root, 15 parts of common fennel fruit, 10 parts of liquorice, 10 parts of earthworm, 15 parts of fragrant solomonseal rhizome and 10 parts of starch.
3. The foot bath formulation according to claim 1, wherein the raw materials further comprise white vinegar having an acetic acid content of 3-4g/100 ml.
4. The foot bath formula according to claim 3, which is prepared from the following raw materials in parts by weight: 25 parts of teasel root, 15 parts of eucommia bark, 20 parts of epimedium herb, 50 parts of stemona root, 50 parts of lightyellow sophora root, 15 parts of common fennel fruit, 10 parts of liquorice, 10 parts of earthworm, 15 parts of fragrant solomonseal rhizome and 10 parts of white vinegar with the acetic acid content of 3.5g/100 ml.
5. A process for preparing the pedicure bath formulation as claimed in claim 2, comprising the steps of:
s1) taking corresponding parts by weight of teasel root, eucommia bark, epimedium herb, sessile stemona root, lightyellow sophora root, common fennel fruit, liquoric root, earthworm and fragrant solomonseal rhizome, and crushing the mixture in a crusher;
s2) mixing the crushed particles with starch in corresponding weight parts, then putting the mixture into a sealed high-pressure frying pan for stir-frying, keeping the sealed state after stir-frying, and slowly cooling to below 10 ℃;
s3) taking the medicinal powder cooled to below 10 ℃ in the step 2 out of a frying pan, and packaging in bags to obtain the foot bath formula powder.
6. The process for preparing the pedicure bath formulation according to claim 5, wherein a proper amount of amylase is mixed into the powder before the powder is packaged in step 3.
7. A process for preparing the pedicure bath formulation as claimed in claim 3 or 4, comprising the steps of:
a) taking the corresponding parts by weight of teasel root, eucommia bark, epimedium herb, sessile stemona root, lightyellow sophora root, common fennel fruit, liquoric root, earthworm and fragrant solomonseal rhizome, and crushing in a crusher;
b) placing the above pulverized particles into a medicine boiler, steaming under high pressure, and filtering the decoction to obtain filtrate;
c) and (3) mixing the filtrate obtained in the step (2) with white vinegar in corresponding parts by weight, and then packaging in bags to obtain the liquid medicine in the foot bath formula.
CN202010970165.7A 2020-09-16 2020-09-16 Foot medicated bath formula and preparation process thereof Pending CN111991527A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010970165.7A CN111991527A (en) 2020-09-16 2020-09-16 Foot medicated bath formula and preparation process thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010970165.7A CN111991527A (en) 2020-09-16 2020-09-16 Foot medicated bath formula and preparation process thereof

Publications (1)

Publication Number Publication Date
CN111991527A true CN111991527A (en) 2020-11-27

Family

ID=73468578

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010970165.7A Pending CN111991527A (en) 2020-09-16 2020-09-16 Foot medicated bath formula and preparation process thereof

Country Status (1)

Country Link
CN (1) CN111991527A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117349452A (en) * 2023-12-04 2024-01-05 长春中医药大学 Information service system for traditional Chinese medicine retrieval

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李春光等: "中药足浴治疗围绝经期综合征的临床疗效观察", 《中国实用医药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117349452A (en) * 2023-12-04 2024-01-05 长春中医药大学 Information service system for traditional Chinese medicine retrieval
CN117349452B (en) * 2023-12-04 2024-02-09 长春中医药大学 Information service system for traditional Chinese medicine retrieval

Similar Documents

Publication Publication Date Title
CN103520654B (en) A kind of Chinese medicine composition being used for the treatment of knee osteoarthritis and preparation method thereof
CN103656238B (en) A kind of Chinese medicine composition for the treatment of rheumatic osteopathia
CN103316146B (en) Traditional Chinese medicinal preparation for anesthesia
CN101912518A (en) Kidney-tonifying and yang-strengthening capsule
CN101028376A (en) Chinese medicinal preparation for treating habitual abortion
CN104815318A (en) Traditional Chinese medicine preparation for treating gout
CN111991527A (en) Foot medicated bath formula and preparation process thereof
CN103656048A (en) Drug for treating cow mastitis and preparation method thereof
CN113318180A (en) A Chinese medicinal composition for treating traumatic injury, and its preparation method
CN102058808A (en) Traditional Chinese medicament for treating rheumatic arthritis
CN105031380A (en) Drug for oral local anesthesia of pregnant woman and preparation method thereof
CN111419924A (en) A topical Chinese medicinal composition for treating various muscle and bone diseases, and its preparation device
CN103977279A (en) Traditional Chinese medicine additive for treating sow hysteritis and preparation method thereof
CN113577166B (en) Medicinal oil and preparation method thereof
CN111084842B (en) External traditional Chinese medicine composition for treating scapulohumeral periarthritis, cervical spondylosis, lumbar disc herniation and osteoarthritis
CN108714173B (en) Traditional Chinese medicine composition and pill for treating femoral head necrosis damp-heat stasis syndrome and preparation method thereof
CN105362944A (en) Traditional Chinese medicine ointment for treating orthopedics sprain and contusion
CN105363005A (en) Kadsura root-bark traditional Chinese medicinal wine
CN116920064A (en) Traditional Chinese medicine formula for treating rheumatic bone diseases and processing method thereof
CN104873858A (en) Traditional Chinese medicine composition for treating functional dysmenorrheal
CN104606642A (en) Gel for treating traumatic injury and preparation method of gel
CN103845493A (en) Oral traditional Chinese medicine for treating acute lumbar muscle sprain and preparation method thereof
CN114699482A (en) Chinese medicinal composition for treating gout and osteopathia pain diseases and preparation method thereof
CN103393927A (en) Medicine for treating climacteric syndrome and preparation method thereof
CN113813322A (en) Medicinal liquor for dispelling cold-dampness and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20201127

RJ01 Rejection of invention patent application after publication