CN111905088A

CN111905088A - Targeted spray moxibustion composition for treating alopecia and preparation and use methods thereof

Info

Publication number: CN111905088A
Application number: CN202010853290.XA
Authority: CN
Inventors: 刘东泰; 王奎荣; 张小炎
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-08-23
Filing date: 2020-08-23
Publication date: 2020-11-10

Abstract

The invention relates to a targeted spray moxibustion composition for treating alopecia, which comprises a tank A and a tank B, wherein the tank A comprises Kunlun jade powder and polygonum multiflorum, and the tank B comprises pearl powder, catalpa bungei leaves and the like. Adding auxiliary materials into the traditional Chinese medicine components, stirring uniformly, adding the mixture into a specific container, sealing with yellow mud, baking at 35-65 ℃, then carrying out low-temperature ultra-micro nano-nano pulverization, diluting with high-boron deuterium-depleted water, pressurizing, filling and preparing into spray. The hair loss treatment method comprises the steps of cleaning a hair loss part of a patient with slight hair loss by warm water, spraying the pot A, performing moxibustion alternately by adopting sparrow pecking moxibustion and mild moxibustion, then uniformly spraying the pot B on the hair loss part, and performing moxibustion treatment on six acupuncture points such as Taiyang acupuncture point, Fengchi acupuncture point and Baihui acupuncture point for patients with serious hair loss.

Description

Targeted spray moxibustion composition for treating alopecia and preparation and use methods thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a targeted moxibustion composition for treating alopecia and preparation and use methods thereof.

Background

Alopecia refers to the phenomenon of hair loss. The normal hair loss is the hair in the catagen and telogen phases, and the normal amount of hair can be maintained because the hair entering the catagen phase and the hair newly entering the anagen phase are constantly in dynamic balance. Pathological hair loss refers to abnormal or excessive hair loss, and the causes mainly include: emotional disorder, wood loss, liver fire obstruction, qi stagnation and blood stasis, meridian obstruction, seborrhea outside the vessels and excessive hair oil; the worms move across the striae, excessive heat toxin and scalp itching; the diseases of feeling wind evil and blocking blood vessels, the skin such as ants move, the diseases are mutually causal, qi stagnation and blood stasis, the channels and collaterals are blocked, the hair is not nourished, and even the hair is withered and withered, so that the hair is lost. The traditional Chinese medicine considers that the pathological factors are only the characteristics, and the root problems of the pathological factors are that the microcirculation of hair follicle cells is not smooth, the metabolism of the cells is slow, nutrient substances are lost, scalp itch, much dandruff, hair oil, withered hair, sparse hair and even withered top are caused over time, the personal image is seriously influenced, and the great psychological burden is brought to patients.

The medicines for treating alopecia in the market are chemical agents, which can treat symptoms and root causes but have large side effects, and the other traditional Chinese medicine adopts topical application, but has long course of treatment and unobvious effect. Therefore, the broad range of patients with alopecia urgently need a therapeutic drug which solves the root cause problem, has good effect and no side effect and a therapeutic method thereof.

Disclosure of Invention

Aiming at the technical background, the technical problem to be solved by the invention is to provide a targeted moxibustion composition for treating alopecia, wherein Kunlun Muyu powder in a tank A can improve the microcirculation of hair follicle cells and promote the absorption of nutrient substances, nano-scale traditional Chinese medicine particles in a tank B are matched to directly target and act on the alopecia part and are assisted with six acupuncture points of a human body to be directly absorbed through skin, and the effective components of the medicine are quickly permeated by combining with the moxibustion therapy, so that the medicine effect is enhanced, and the effect is better.

In order to solve the technical problems, the invention adopts the technical scheme that:

a targeted moxibustion composition for treating alopecia comprises jar A and jar B, wherein jar A comprises Kunlun Cuiyu powder and Polygoni Multiflori radix, and jar B comprises Margarita powder, folium catalpae bungei, folium Mori, folium Platycladi, Saviae Miltiorrhizae radix, Polygoni Multiflori radix, rhizoma Zingiberis recens juice, Ecliptae herba, semen Torreyae, and vinegar extract.

Further, the components are mixed according to the parts by weight:

and (4) tank A:

8-12 parts of Kunlun Muyu powder and 6-10 parts of polygonum multiflorum

And (4) tank B:

a preparation method of a targeted spray moxibustion composition for treating alopecia comprises the following steps:

s01: baking with slow fire: weighing the components of the composition according to the weight part ratio, cleaning, adding auxiliary materials, stirring uniformly, adding into a container fired by adding clay, medical stone powder and jasper powder, sealing with yellow mud, and baking in a baking room at 35-65 ℃;

s02: nano-crushing: adding high-boron deuterium-depleted water, and micronizing at 25 deg.C to obtain suspension containing Chinese medicinal particles with nanometer particle size;

s03: and (3) sterilization and filling: short-time microwave sterilization, high-boron deuterium-depleted water dilution, pressurization filling and spray preparation.

Further, the auxiliary materials in the S01 include one or more of honey, yellow wine, bran, salt and vinegar.

A use method of a targeted spray moxibustion composition for treating alopecia comprises the steps of cleaning a alopecia part with warm water, spraying a pot A, alternately performing moxibustion by adopting sparrow pecking moxibustion and mild moxibustion, and uniformly spraying a pot B on the alopecia part for moxibustion for 15-20 minutes.

Furthermore, the moxibustion part also comprises Sanyinjiao, Zusanli, Hegu, Taiyang, Fengchi and Baihui, the pot A is sprayed firstly, and the sparrow-pecking moxibustion and the mild moxibustion are adopted to carry out moxibustion alternately, wherein each acupuncture point is used for moxibustion for 15-20 minutes, and then the pot B is sprayed for moxibustion for 15-20 minutes.

The invention has the advantages that:

(1) the root cause problem of alopecia caused by specially adding the Kunlun Mayu powder injection is solved, the microcirculation of hair follicle cells is improved, the absorption of the hair follicle cells to nutrient substances is promoted, and the nutrient supply of hair is promoted;

(2) according to the invention, the combination form of the tank A and the tank B is adopted, so that the reduction of the activity of the medicinal ingredients in the tank B in the process of conditioning and improving hair follicle cell microcirculation by Kunlun jasper powder during simultaneous action is avoided;

(3) the invention firstly bakes the traditional Chinese medicine components with slow fire to increase the drug effect, and then crushes the traditional Chinese medicine components to nano-grade grain diameter at low temperature, and the traditional Chinese medicine components can be directly absorbed through skin.

Detailed Description

The technical solution of the present invention is described below clearly and completely with reference to specific embodiments, and it is obvious that the described embodiments are only some embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that: a targeted moxibustion composition for treating alopecia comprises jar A and jar B, wherein jar A comprises Kunlun Cuiyu powder and Polygoni Multiflori radix, and jar B comprises Margarita powder, folium catalpae bungei, folium Mori, folium Platycladi, Saviae Miltiorrhizae radix, Polygoni Multiflori radix, rhizoma Zingiberis recens juice, Ecliptae herba, semen Torreyae, and vinegar extract.

The components are mixed according to the parts by weight:

and (4) tank A:

8-12 parts of Kunlun Muyu powder and 6-10 parts of polygonum multiflorum

And (4) tank B:

the main components have the following functions in the system:

kunlun black jade powder: through scientific detection, the Kunlun Muyu powder contains more than thirty mineral substances and trace elements which are beneficial to the human body, and can permeate into cells of the human body for a long time, keep the balance of various elements in the human body and achieve the effects of removing diseases and building the body; the far infrared microwave emittance can improve the microcirculation of hair follicle cells, enhance the cell activity, promote the cell metabolism and promote the absorption of cells to nutrient components.

Polygonum multiflorum: sweet and warm in taste; has metabolism promoting effect, and the Polygoni Multiflori radix injection has obvious enhancement effect on rat suckling mouse hepatocyte DNA replication by 0.16, 0.03, 0.01mg/mL in vitro culture method; nourishing blood and yin, it is indicated for early white beard and hair.

Pearl powder: scavenging free radicals, and promoting metabolism. The pearl powder contains manganese, copper and zinc, which are the components of SOD (superoxide dismutase), and can promote the activity of SOD, remove free radicals in vivo and promote metabolism.

Cacumen biotae: bitter, astringent and cold. Mainly treats blood heat alopecia and premature graying of beard and hair, and has the effects of growing hair and blackening hair.

And (3) eclipta: sweet and sour in flavor, neutral. It is used for treating thin hair and premature gray hair.

S01 the adjuvants include one or more of Mel, yellow wine, testa Tritici, salt, and vinegar.

The traditional Chinese medicine components are baked by slow fire to increase the drug effect, and then are subjected to an ultramicro nano-pulverization technology, a high-speed air vortex is utilized to form an air knife, substances are subjected to ultramicro-granulation at a low temperature below 25 ℃, the original molecular structure of the substances is not damaged, the effect of the substances is retained to the greatest extent, the obtained traditional Chinese medicine particles are nano-sized and can be completely suspended in spray liquid, the diameter of pores is about 20-50 microns, the nano-sized traditional Chinese medicine particles can be directly absorbed through the skin, the permeability is good, and the problem that the common traditional Chinese medicine components are large in particle size and are not easy to absorb is solved. The obtained nanoscale Kunlun Muyu powder can effectively improve the microcirculation of hair follicle cells, promote metabolism, promote the absorption of cells to other traditional Chinese medicine components, directly target to hair loss parts, and supplement six acupuncture points of a human body for severe alopecia patients, clear and activate the channels and collaterals, promote absorption and radically solve the problem of alopecia.

The high-boron deuterium-depleted water is adopted for dilution, researches show that the deuterium-depleted water can promote the activity of enzymes in the body, enhance the immunity of the body, effectively remove acidic waste in blood, improve the internal environment, enhance the cell activity, promote the cell metabolism and promote the absorption of nutrient substances, meanwhile, boron ions have the bacteriostatic effect, the boron ions can effectively enhance the drug effect when being used as a diluent of the moxibustion spraying composition, and the high-boron deuterium-depleted water is used for dilution and is beneficial to filling and spraying.

A use method of a targeted spray moxibustion composition for treating alopecia comprises the steps of cleaning a mild patient moxibustion part which is an alopecia part with warm water, spraying a pot A, performing moxibustion by adopting sparrow pecking moxibustion and mild moxibustion alternately, and then uniformly spraying a pot B on the alopecia part for moxibustion for 15-20 minutes; for severe alopecia, the moxibustion part also comprises Sanyinjiao, Zusanli, Hegu, Taiyang, Fengchi and Baihui, the pot A is sprayed, and the moxibustion is performed by alternately performing sparrow pecking and mild moxibustion, wherein each acupuncture point is subjected to moxibustion for 15-20 minutes, and then the pot B is sprayed, and the moxibustion is performed for 15-20 minutes.

The nano Kunlun jasper powder in the tank A acts on the hair loss part in a transdermal manner, so that the microcirculation of hair follicle cells can be improved, the cell activity is enhanced, the cell metabolism is promoted, and the absorption of cells to other traditional Chinese medicine components is promoted, so that the active ingredients of the traditional Chinese medicine in the tank B can be efficiently exerted and absorbed in a transdermal manner, and the active ingredients directly act on the hair loss part in a targeted manner; for patients with serious alopecia, moxibustion of six acupuncture points of a human body is assisted to clear and activate the channels and collaterals, the rapid absorption of medicinal components is promoted, local medication is replaced, the treatment course is shortened, and the moxibustion is performed by alternately adopting sparrow pecking moxibustion and mild moxibustion after two times of spraying, so that the effective components of the medicaments can quickly permeate to the action part, the medicinal effect is enhanced, and the effect is better.

Example 1

The components are mixed according to the parts by weight:

and (4) tank A:

kunlun Muyu powder 8 parts and fleece-flower root 6 parts

And (4) tank B:

the composition is prepared by adopting the following steps:

The application method of the spray moxibustion composition comprises the steps of cleaning a mild patient moxibustion part which is a alopecia part with warm water, spraying the pot A, alternately performing moxibustion by adopting sparrow pecking moxibustion and mild moxibustion, and uniformly spraying the pot B on the alopecia part for 15-20 minutes; for severe alopecia, the moxibustion part also comprises Sanyinjiao, Zusanli, Hegu, Taiyang, Fengchi and Baihui, the pot A is sprayed, and the moxibustion is performed by alternately performing sparrow pecking and mild moxibustion, wherein each acupuncture point is subjected to moxibustion for 15-20 minutes, and then the pot B is sprayed, and the moxibustion is performed for 15-20 minutes.

Example 2

The components are mixed according to the parts by weight:

and (4) tank A:

kunlun Muyu powder 10 parts and fleece-flower root 8 parts

And (4) tank B:

the preparation and use methods are the same as above.

Example 3

The components are mixed according to the parts by weight:

and (4) tank A:

kunlun Muyu powder 12 parts and fleece-flower root 10 parts

And (4) tank B:

the preparation and use methods are the same as above.

Comparative example 1

Tank a contained no kunlun topaz powder, and the rest was the same as in example 2.

Comparative example 2

The composition of example 2 was applied to the human body in both tank A and tank B, and the rest were the same.

Comparative example 3

The composition in the example 2 is directly and commonly ground without being baked by slow fire, sieved by a 100-mesh sieve, sterilized and filled, and the rest are the same.

The present invention is further described below in terms of an animal test and a volunteer use effect test.

First, animal experiment

70 adult mice weighing 200-300 g were randomly divided into seven groups, each group corresponding to the test of the above-mentioned spray moxibustion composition prepared in examples 1-3 and the spray moxibustion composition prepared in comparative examples 1-3, and the remaining group was a control group. Hair was removed from the backs of all mice with a hair clipper the day before the test, in the range of 3 x 3 cm. After 1 month, 10 longest hairs are selected by visual observation and measured by a vernier caliper, the average value is taken as a mouse hair regeneration length value, then the hairs on the tested part are collected and weighed to be used as a mouse hair growth weight value, and the statistical results of all the test data are detailed in the following table 1.

Table 1 mouse regrowth hair growth and hair weight test

As can be seen from Table 1, the moxibustion compositions prepared in the examples of the respective groups have not only hair growth promoting effects but also hair thickening effects, and can improve the problem of hair thinning and breakage to some extent, as compared with the comparative examples.

Second, effect test

(I) alopecia prevention Effect test

300 volunteers were divided into six groups, each half of each group of men and women, and the spray moxibustion composition prepared in examples 1 to 3 and the spray moxibustion composition of comparative examples 1 to 3 were used for 2 times per day for 1 month continuously, during which the volunteers combed hair 3 times in the morning, the evening, and the number of the hair removed was collected and recorded, and the average value was found and the integer was taken, and the statistical results are detailed in table 2 below.

TABLE 2 alopecia prevention Using Effect of the present invention

As can be seen from table 2, the number of hair loss of the volunteers using the spray moxibustion compositions prepared in the examples of each group was significantly reduced with the increase of the use time, and the number of hair loss was reduced by more than 70% within one month, while the number of hair loss of the volunteers using the spray moxibustion compositions prepared in the comparative ratio of each group was reduced by less than 35%.

(II) Hair growth Effect test

300 volunteers were divided into six groups, each half of each group of men and women, and the spray moxibustion composition prepared in examples 1-3 and the spray moxibustion composition of comparative examples 1-3 were used for 2 times per day for 1 month continuously, and the statistical results of the curative effect are detailed in the following table 3.

The judgment standard of the curative effect condition is as follows:

has obvious effects that the new hair regeneration reaches more than 70 percent, the hair is not dropped outside, the hair quality is close to a hair-care area, and the scalp is not itchy and oily;

effective-more than 30% of new hair regeneration, no external shedding, improved hair quality and reduced itching feeling and greasiness;

ineffective, i.e. less than 30% of new hair regeneration or continued alopecia, itchy scalp, oily hair and no improvement in hair quality.

TABLE 3 effect of the present invention on the regeneration

Group of	n	Show effect	Is effective	Invalidation	Total effective rate
						Example 1	50	40	8	2	96％
Example 2	50	45	5	0	100％
						Example 3	50	42	7	1	98％
Comparative example 1	50	26	8	16	68％
						Comparative example 2	50	28	9	13	74％
Comparative example 3	50	24	6	20	60％

As can be seen from table 3, compared with the comparative examples, the effective rate of the moxibustion spray composition prepared in each group of examples in treating alopecia is higher, and is more than 96%, and no adverse reaction occurs to the user in the test stage, which indicates that the moxibustion spray composition has a significant effect in treating alopecia.

Typical cases are:

1. in a certain car, a man is in 31 years old, scalp itch and dandruff increase in the first two years, but the current situation is further worsened because the work is busy and cannot attract the attention of a patient, the hairline moves backwards, the forehead is bald and big, the whole person looks old and good, and the married age is not found due to image problems. The spray moxibustion composition is firstly sprayed on the pot A to act on the hair loss part, sparrow pecking moxibustion and mild moxibustion are alternately used for moxibustion, each acupuncture point is used for moxibustion for 15-20 minutes, and then the pot B is uniformly sprayed on the hair loss part for moxibustion for 15-20 minutes. After the hair-care product is used for 1 month, symptoms of itching and scurf of the head are improved, new hairs grow on the forehead after the hair-care product is continuously used for 3 months, the whole hair volume is obviously increased, and the hair-care product is not convenient for half a year and is married with favorite girl collar certificates.

2. Some women, 48 years old, have old age and young age in the middle-aged, home housework can not be lost, the working pressure is large, the hair loss problem is more and more serious, the hair loss is continuous, the hair is sparse, the scalp can be seen even in places with hair braids, the sexual condition of some people is also changed greatly, and people do not like to meet sisters. The spray moxibustion composition is firstly sprayed on the A pot to act on six acupuncture points of a baldness part, a three-yin crossing point, a three-li point, a Hegu point, a temple point, a Fengchi point and a Baihui point of a human body, sparrow pecking moxibustion and mild moxibustion are alternately adopted for moxibustion, each acupuncture point is subjected to moxibustion for 15-20 minutes, and then the B pot is uniformly sprayed on the baldness part for moxibustion for 15-20 minutes. After 2 months of use, the hair falling amount of each comb is obviously reduced, and after 4 months of continuous use, the hair amount is restored to the previous level, and the hair quality is better than the previous level.

3. In a certain child, male, 51 years old, the scalp is itchy and greasy before two years, seborrheic alopecia is caused, the later period is gradually serious and even withers to the top, and the doctor visits each large hospital, the traditional Chinese medicine and the western medicine are tried, the effect is still not obvious, or the disease recurs after the medicine is stopped. The spray moxibustion composition is firstly sprayed on the A pot to act on six acupuncture points of a baldness part, a three-yin crossing point, a three-li point, a Hegu point, a temple point, a Fengchi point and a Baihui point of a human body, sparrow pecking moxibustion and mild moxibustion are alternately adopted for moxibustion, each acupuncture point is subjected to moxibustion for 15-20 minutes, and then the B pot is uniformly sprayed on the baldness part for moxibustion for 15-20 minutes. After 2 months of use, the phenomena of head itching and head oil are obviously improved, the head is full of hair for half a year, and the hair does not relapse after follow-up visit in later period.

Although the present invention has been described in detail with reference to the above description, the design concept of the present invention is not limited thereto. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. The present invention is not limited to the above embodiments, and various modifications and changes may be made without departing from the spirit and scope of the present invention.

Claims

1. A targeted moxibustion composition for treating alopecia is characterized in that: comprises jar A and jar B, wherein jar A comprises Kunlun Cuiyu powder and Polygoni Multiflori radix, and jar B comprises Margarita powder, folium catalpae bungei, folium Mori, folium Platycladi, Saviae Miltiorrhizae radix, Polygoni Multiflori radix, rhizoma Zingiberis recens juice, Ecliptae herba, semen Torreyae, and vinegar paste.

2. The targeted moxibustion composition for treating alopecia as claimed in claim 1, wherein: the components are mixed according to the parts by weight:

and (4) tank A:

8-12 parts of Kunlun Muyu powder and 6-10 parts of polygonum multiflorum

And (4) tank B:

3. the method for preparing the targeted moxibustion composition for treating alopecia according to any one of claims 1 to 2, wherein the targeted moxibustion composition comprises the following components: the method comprises the following steps:

4. The preparation method of the targeted moxibustion composition for treating alopecia according to claim 3, wherein the preparation method comprises the following steps: s01 the adjuvants include one or more of Mel, yellow wine, testa Tritici, salt, and vinegar.

5. The use method of the targeted moxibustion composition for treating alopecia according to any one of claims 1 to 2, wherein the composition comprises the following components: the position to be treated by moxibustion is a hair loss position, the hair loss position is cleaned by warm water, the pot A is sprayed, the sparrow pecking moxibustion and the mild moxibustion are adopted for alternate moxibustion, and the pot B is uniformly sprayed on the hair loss position for moxibustion for 15-20 minutes.

6. The method of using the targeted moxibustion composition for treating alopecia as claimed in claim 5, wherein: the moxibustion part also comprises Sanyinjiao, Zusanli, Hegu, Taiyang, Fengchi and Baihui, the A pot is sprayed firstly, the sparrow pecking moxibustion and the mild moxibustion are adopted for alternate moxibustion, each acupuncture point is subjected to moxibustion for 15-20 minutes, and then the B pot is sprayed for moxibustion for 15-20 minutes.