CN108159347B

CN108159347B - Traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome and preparation method thereof

Info

Publication number: CN108159347B
Application number: CN201810011327.7A
Authority: CN
Inventors: 何峰; 王敏; 陆学超; 刘康; 段长农
Original assignee: Shandong Normal University
Current assignee: Shandong Normal University
Priority date: 2018-01-05
Filing date: 2018-01-05
Publication date: 2020-11-20
Anticipated expiration: 2038-01-05
Also published as: CN108159347A

Abstract

The invention provides a traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 12-18 parts of lotus seeds; 10-15 parts of cortex albiziae; 1-4 parts of amber powder; 12-18 parts of spina date seeds; 4-8 parts of radix bupleuri; 12-18 parts of white peony root; 8-12 parts of curcuma aromatica; 12-18 parts of oldenlandia diffusa; 6-12 parts of cimicifugae foetidae, 6-12 parts of liquorice, 10-15 parts of white hyacinth beans, 4-8 parts of fructus amomi, 1-5 parts of fructus evodiae, 8-12 parts of pomegranate rind, 6-12 parts of nutmeg and 8-12 parts of myrobalan. Through long-term clinical practice and by combining with modern pathogenesis research of IBS, namely that anxiety and IBS have common biological factors, the thinking of 'treatment by disease differentiation and simultaneous treatment of the mind and body' is provided, and patients suffering from diarrhea IBS are brought into the treatment method and the treatment method of 'calming the nerves, relieving depression, strengthening the spleen and stopping diarrhea' according to the western medicine diagnosis standard, so that the obvious curative effect is achieved. Simple steps, convenient operation and strong practicability.

Description

Traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome and preparation method thereof

Technical Field

The invention belongs to the field of Irritable Bowel Syndrome (IBS) treatment, and particularly relates to a traditional Chinese medicine composition for treating diarrhea-predominant IBS and a preparation method thereof.

Background

Irritable Bowel Syndrome (IBS) is a psychosomatic disorder characterized by gastrointestinal dysfunction. The clinical manifestations are abdominal pain, diarrhea, constipation and abnormal stool behavior (loose stool, mucous stool or hard stool), and most patients are accompanied by mental symptoms such as insomnia, anxiety, depression, dizziness, headache, etc. (Elsenbruch, 2011). Relevant epidemiological investigations have shown that IBS prevalence is as high as 10-15% in north america (Canavan et al, 2014) and 5-10% in asian countries (Chang et al, 2007); in different areas of our country 5.7-11.5% (li xiao qing et al, 2013, fei zhu wei et al, 2006, bear keeping et al, 2002). According to estimates in the European and American countries, the direct annual cost of clinical treatment for IBS is as high as $ 17 billion per year. Therefore, IBS not only seriously affects the learning, working and life quality of patients, but also increases medical resource consumption and brings serious social and economic burden.

IBS patients have a high sensitivity to stress. Epidemiological investigations have found that IBS patients experience more major life stress events compared to healthy populations, with a much higher proportion of mental/psychological symptoms than other organic diseases (Enck et al, 2007, Olden, 2006). The diagnostic rate of psychiatric disorders in IBS patients seeking treatment varies from 54% to 94%, with anxiety (according to DSM-IV diagnostic criteria in the united states) being the most common complication, with diagnostic rates as high as 61% (Levy et al, 2006, Whitehead et al, 2002). "biological factors common to anxiety and IBS" are becoming a common consensus among researchers (Myers et al, 2009).

IBS can be classified into 4 types of diarrhea type, constipation type, mixed type, and indeterminate type, with diarrhea type IBS being the most common type. According to the clinical symptoms of diarrhea-type IBS patients, the diarrhea-type IBS can be brought into the categories of symptoms such as abdominal pain and diarrhea in traditional Chinese medicine, and the disease location is in the stomach and large intestine and closely related to the liver, spleen and kidney. The description of the pathogenesis of the disease can be traced to the theory of 'liver disease spleen transmission' proposed in the 'jin Kui Yao L ü e'. In recent years, the pathogenesis of the disease is mainly discussed as the dysfunction of the spleen, spleen and stomach, dysfunction of the intestine and the transportation and transmission function of the spleen, stomach and intestine are lost, which causes dysfunction of the spleen in transportation, ascending and descending, dysfunction of the intestine and dysfunction of the spleen in transmission, and finally causes the disease with the same spleen and kidney disease after long-term use. According to the traditional Chinese medicine, diarrhea-type IBS is clinically classified into various symptoms such as weakness of spleen and stomach, liver wood with spleen, liver depression and spleen deficiency, cold and heat with mixed, spleen and stomach deficiency cold, spleen deficiency and dampness excess, liver and spleen disharmony and the like for dialectical treatment, and bupleuri radix liver soothing powder, a pain-relieving prescription, a Siadverse qi decoction, a peony and licorice decoction, a Lidongyuan yang-invigorating and stomach-benefiting decoction, a Sishen pill, a liver-warming decoction, a Chaishao Liujunzi decoction and the like are usually selected for addition and subtraction treatment, but the clinical curative effect is not ideal, the typing is complex, and the operability is poor.

There are only 2 currently approved FDA approved prescription drugs for treatment of diarrhea-predominant IBS in the united states, the two drugs being Viberzi and Xifaxan (approved in 2015). The mechanism of action of Viberzi is to reduce intestinal constriction, thereby alleviating diarrhea; while Xifaxan belongs to the class of antibiotics and reduces diarrhea by altering intestinal bacteria. Both of them are local and symptomatic treatments, and the diseases are easy to recur after stopping taking the medicine, and can generate drug resistance after long-term use.

The disadvantages of clinical Irritable Bowel Syndrome (IBS) therapeutic drugs are specifically summarized as follows:

1) lack of drugs for simultaneous treatment of both principal and secondary aspects;

2) only 2 approved prescription drugs for treating diarrhea-type IBS by FDA in the United states currently have the effect on intestinal tracts, and the clinical effect is not ideal;

3) the traditional Chinese medicine therapy has wide prospect, but the clinical symptom dialectical prescription is needed, the factors of the prescription receiver are large, and the wide applicability is lacked;

4) for diarrhea-predominant irritable bowel syndrome, the traditional Chinese medicine clinical treatment prescription is various, and the effect is uncertain.

Disclosure of Invention

In order to overcome the defects, the invention provides a traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome and a preparation method thereof. For years, through long-term clinical practice and by combining with modern pathogenesis research of IBS, namely that anxiety and IBS have common biological factors, the thinking of 'treatment by disease differentiation and simultaneous treatment of mind and body' is provided, and patients suffering from diarrhea IBS are brought into the treatment method and the treatment method of 'calming nerves, relieving depression, strengthening spleen and stopping diarrhea' according to the western medicine diagnosis standard, so that the obvious curative effect is achieved.

In the formula, the spina date seed is a key medicine for nourishing the heart and soothing the nerves, is sour, sweet and mild in taste, is fried to be sour, warm and fragrant, is used for nourishing heart yin, benefiting liver blood and activating spleen to invigorate spleen, and is used as a monarch medicine. Amber calms the nerves, cortex albiziae calms the nerves and relieves depression, lotus seed nourishes the heart and tonifies the kidney, tonifies the spleen to arrest diarrhea, pomegranate rind astringes intestines to arrest diarrhea, and the four medicines can assist the monarch drug and serve as ministerial drugs. The radix curcumae has the effects of activating blood and promoting qi circulation, and has the effects of promoting qi circulation, relieving depression, nourishing blood and softening liver by combining with the radix bupleuri and the radix paeoniae alba; fructus Amomi, fructus evodiae and semen lablab album are used together to warm spleen and stomach, dispel cold, tonify spleen and check diarrhea, and semen Myristicae and fructus Chebulae are used as adjuvant drugs for relieving diarrhea with astringents; herba Hedyotidis Diffusae and cimicifugae rhizoma are included in the large intestine channel, and the contained terpenoids have antiinflammatory and antibacterial effects, and can be used as adjuvant drugs for enhancing antidiarrheal effect. Licorice root, radix Glycyrrhizae has the effect of harmonizing the drugs in the recipe and acts as a guiding drug.

The invention aims to achieve the following technical effects:

1) the purpose of the invention is as follows: to provide an effective method for treating diarrhea-predominant IBS; improving the treatment effect of IBS.

2) The invention is established on the basis of the research of the combination of Chinese and Western medicine, and has definite effect of treating diarrhea type IBS through clinical application;

3) the invention is a prescription for disease differentiation treatment aiming at the diagnosis result of western medicine, and has effectiveness and usability.

In order to achieve the purpose, the invention adopts the following technical scheme:

a traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome is prepared from the following raw material medicines in parts by weight: 12-18 parts of lotus seeds; 10-15 parts of cortex albiziae; 1-4 parts of amber powder; 12-18 parts of spina date seeds; 4-8 parts of radix bupleuri; 12-18 parts of white peony root; 8-12 parts of curcuma aromatica; 12-18 parts of oldenlandia diffusa; 6-12 parts of cimicifugae foetidae, 6-12 parts of liquorice, 10-15 parts of white hyacinth beans, 4-8 parts of fructus amomi, 1-5 parts of fructus evodiae, 8-12 parts of pomegranate rind, 6-12 parts of nutmeg and 8-12 parts of myrobalan.

Preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 12-15 parts of lotus seeds; 10-12 parts of cortex albiziae; 1-2 parts of amber powder; 12-15 parts of spina date seeds; 4-6 parts of radix bupleuri; 12-15 parts of white peony root; 8-10 parts of curcuma aromatica; 12-15 parts of oldenlandia diffusa; 6-9 parts of cimicifugae foetidae, 6-9 parts of liquorice, 10-12 parts of white hyacinth beans, 4-6 parts of fructus amomi, 1-3 parts of fructus evodiae, 8-10 parts of pomegranate rind, 6-9 parts of nutmeg and 8-10 parts of myrobalan.

Preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 15-18 parts of lotus seeds; 12-15 parts of cortex albiziae; 2-4 parts of amber powder; 15-18 parts of spina date seeds; 6-8 parts of radix bupleuri; 15-18 parts of white peony root; 10-12 parts of curcuma aromatica; 15-18 parts of oldenlandia; 9-12 parts of cimicifugae foetidae, 9-12 parts of liquorice, 12-15 parts of white hyacinth beans, 6-8 parts of fructus amomi, 3-5 parts of fructus evodiae, 10-12 parts of pomegranate rind, 9-12 parts of nutmeg and 10-12 parts of myrobalan.

Preferably, the traditional Chinese medicine composition is prepared into decoction, tablets, granules, pills or oral liquid.

The invention also provides a traditional Chinese medicine preparation for treating diarrhea-predominant irritable bowel syndrome, which comprises any one of the traditional Chinese medicine compositions.

The invention also provides a preparation method of the traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome, which comprises the following steps:

1) honey-fried cimicifugae rhizoma and Glycyrrhrizae radix; the honey-processed cimicifuga foetida can relieve the pungent and scattered property, has the function of raising spleen yang and reduces the stimulation to stomach; the liquorice is divided into two types of honey-fried liquorice and raw liquorice according to the existence of the processing, and the effect of tonifying heart and spleen qi is enhanced by using the characteristic of mild drug property of honey-fried liquorice in the application.

2) Parching semen Ziziphi Spinosae; and (4) processing by a conventional method. The fried spina date seed is crisp, is beneficial to decocting out effective components and improves the curative effect. Another research shows that the total saponins of semen Ziziphi Spinosae in parched semen Ziziphi Spinosae are significantly higher than those of semen Ziziphi Spinosae.

3) Parching semen lablab album and pericarpium Granati with sand; parched semen lablab album and pericarpium Granati can enhance its effects in invigorating spleen, warming middle warmer, and relieving diarrhea, and the sand parching method can heat the medicinal materials uniformly to improve the quality of the medicinal materials.

4) Processing bupleuri radix with vinegar; bupleurum root, radix bupleuri, bitter and pungent in flavor and slightly cold in nature, can relieve exterior syndrome and soothe the liver. The unprocessed one has the effect of relieving exterior syndrome and removing heat, while the vinegar moxibustion method can introduce the medicine into liver and strengthen the effect of bupleurum root in soothing liver and relieving depression, so the vinegar processed bupleurum root is taken as the medicine in the application.

5) Coating with roasted semen Myristicae and fructus Chebulae; nutmeg contains a large amount of oil, has the disadvantage of intestine lubricating and strong irritation, and is generally roasted for oil removal and then taken; roasted myrobalan is slightly warm in nature and can reduce irritation to stomach. The combination of the two can strengthen the action of inducing astringency, so it is indicated for deficiency-cold of spleen and stomach, persistent diarrhea, abdominal distention and pain, poor appetite and vomiting.

6) Cortex Albizziae, Succinum powder, radix Paeoniae alba, radix Curcumae, herba Hedyotidis Diffusae, fructus evodiae, semen Nelumbinis and fructus Amomi are unprocessed, and semen Nelumbinis (without removing core) and fructus Amomi are smashed.

7) Except the amber powder, the other medicines are mixed according to the formula proportion, soaked and decocted according to the conventional method to obtain traditional Chinese medicine decoction, the amber powder is added after the dregs of a decoction are filtered, and the mixture is stirred uniformly to be taken.

The invention also provides a preparation method of the capsule for treating diarrhea-predominant irritable bowel syndrome, which comprises the following steps:

a) preparing a traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome according to the method, soaking in water, extracting volatile oil, and collecting liquid medicine and dregs respectively;

b) extracting the medicine residues in the step 1) with alcohol for 3 times, combining extracting solutions, filtering, concentrating, precipitating with ethanol twice, taking supernate, and concentrating to obtain extract;

c) mixing the extract of step b) with the volatile oil of step a), grinding, and encapsulating.

The invention also provides a preparation method of the tablet for treating diarrhea-predominant irritable bowel syndrome, which comprises the following steps:

a) preparing a traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome according to the method, heating and refluxing the traditional Chinese medicine composition with ethanol to extract active ingredients, combining the extracting solutions to obtain an extracting solution I, and collecting dregs;

b) extracting the residue with water under reflux for three times, mixing extractive solutions to obtain extractive solution II, mixing extractive solutions I and II, recovering ethanol under reduced pressure, concentrating, vacuum filtering, and eluting the filtrate twice with column to obtain medicinal liquid; adding starch and pressing into tablet.

Preferably, the decoction is one dose per day; the tablet and capsule preparation is taken at a dose of 1 g/day/person per day, and is equivalent to 6.0g crude drug/day/person according to crude drug amount.

The invention also provides application of any one of the traditional Chinese medicine compositions in preparing a medicine with the effect of treating patients with anxiety and IBS coexisting.

The invention has the advantages of

(1) The invention starts from the etiology of IBS pathogenesis and combines different efficacies of a plurality of traditional Chinese medicines to realize disease differentiation treatment and psychosomatic simultaneous treatment. Can treat both principal and secondary aspect of disease and has easy operation.

(2) The prescription of the Chinese medicinal composition is special in compatibility, and the 16 Chinese medicinal compositions realize the effects of soothing nerves, resolving depression, invigorating spleen and stopping diarrhea; the fixed prescription treatment meets the diagnosis standard of diarrhea IBS in Western medicine; accurate and necessary medicament processing requirements in the formula.

(3) The preparation method is simple, good in treatment effect, strong in practicability and easy to popularize.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The present invention will be further described with reference to specific examples.

1. The formula and the weight proportion of the raw material medicines are as follows:

1) decoction dosage/day:

15g of lotus seeds; 12g of silktree albizzia bark; 2g of amber powder; 15g of spina date seeds; 6g of radix bupleuri; 15g of white peony root; 10g of radix curcumae; 15g of oldenlandia; 9g of cimicifugae foetidae, 9g of liquorice, 12g of white hyacinth beans, 6g of fructus amomi, 3g of fructus evodiae, 10g of pomegranate rind, 9g of nutmeg and 10g of myrobalan;

2) the compatibility proportion of the capsule and the tablet is as follows:

15 parts of lotus seeds; 12 parts of cortex albiziae; 2 parts of amber powder; 15 parts of spina date seeds; 6 parts of radix bupleuri; 15 parts of white peony root; 10 parts of radix curcumae; 15 parts of oldenlandia; 9 parts of cimicifuga foetida, 9 parts of liquorice, 12 parts of white hyacinth beans, 6 parts of fructus amomi, 3 parts of fructus evodiae, 10 parts of pomegranate rind, 9 parts of nutmeg and 10 parts of myrobalan;

2. the preparation method comprises the following steps:

1) honey-fried cimicifugae foetidae and licorice: diluting refined honey with boiled water at a ratio of 6:4, spraying into cimicifugae rhizoma or Glycyrrhrizae radix tablet, stirring, and parching in container. Heating with an electric ceramic furnace at 800w power, taking out and cooling when stir-frying is not sticky. 30g of refined honey is used for every 100g of rhizoma cimicifugae or liquorice tablets;

2) parching semen Ziziphi Spinosae: parching semen Ziziphi Spinosae with slow fire until outer skin swells (150 deg.C, 5 min).

3) Stir-frying white hyacinth bean and pomegranate rind with sand: placing a proper amount of sand in a medicine frying pan, heating for 5 minutes at 2200w power by using an electric ceramic furnace, reducing the heating to 800w power, adding white hyacinth beans or pomegranate rind, stir-frying, stopping fire when the medicinal materials become slightly yellow, and continuously stir-frying by using the residual temperature of the sand until the surface is brown. Sieving to remove sand and soil, and mashing.

4) Processing bupleuri radix with vinegar; mixing the radix bupleuri green sheet with rice vinegar, moistening thoroughly, placing in a pan, parching with slow fire, taking out, and cooling.

5) Coating roasted nutmeg and myrobalan on the surface: moistening semen Myristicae or fructus Chebulae, wrapping with 3 layers of flour, adding into parched hot sand, parching at 180 deg.C for 20 min, taking out, sieving to remove sand, peeling, and cooling.

7) Except the amber powder, the other medicines are mixed according to the formula proportion, soaked and decocted according to the conventional method to obtain traditional Chinese medicine decoction, the amber powder is added after the dregs of a decoction are filtered, and the mixture is stirred uniformly to be taken. Or making into capsule, tablet, granule, pill, oral liquid, etc.

1. The application of the medicine is as follows: can be used for treating diarrhea type IBS.

2. The effect of the use of the drug and the principle of the drug to achieve its function:

the formula has the effects of soothing the nerves, relieving depression, strengthening the spleen and stopping diarrhea, and has effects for scientific formula of each medicine in the formula. Wherein the functions of the components are as follows:

1) lotus seed (without lotus plumule): the semen Nelumbinis is mature seed of Nelumbo nucifera Gaertn of Nymphaeaceae. Sweet, astringent and mild in taste. It enters spleen, kidney and heart meridians. Has effects in nourishing heart, invigorating kidney, invigorating spleen, relieving diarrhea, stopping nocturnal emission, and stopping leukorrhagia. It can be used for treating diarrhea due to spleen deficiency, palpitation, insomnia, leukorrhagia, spermatorrhea, and soreness of waist and knees. Compendium of materia Medica: ' Lian Zi (Lotus seed) is used to give attention to heart and kidney, nourish intestines and stomach, secure essence, strengthen tendons and bones, tonify deficiency and impair, … …. Stopping spleen-draining diarrhea, chronic dysentery, red and white turbidity, and leukorrhagia and metrorrhagia of women; jade mountain ash Yao Jie (Yao Jie): "Lian Zi is sweet and neutral, so it is good for spleen and stomach, inducing astringency, so it is most suitable for diarrhea, seminal emission and loose stool, and has very good effect. The lotus plumule is the green and tender embryo of lotus seed. Bitter taste and cold nature. Has effects of clearing heart fire and tranquilizing mind. Modern pharmacology researches that the lotus plumule contains various alkaloids with arrhythmia resisting and blood pressure lowering effects, such as liensinine, neferine and the like, show that the medicine can adjust autonomic nerve excitability and provide experimental basis for the effect of nourishing the heart and soothing the nerves.

2) Silktree albizzia bark: is dried bark of Albizzia julibrissin Durazz of Leguminosae. Sweet and mild in taste. It enters heart, liver and kidney meridians. Has the effects of soothing the nerves, relieving depression, promoting blood circulation, eliminating swelling and the like. It is mainly used for treating restlessness, anger, depression, dysphoria, insomnia, etc. Shen nong Ben Cao Jing: "governing and regulating five zang organs and heart, it is happy and carefree. The modern pharmacology research shows that the albizia julibrissin durazzini water extract has an anxiolytic effect, and can possibly play a role through a brain 5-hydroxytryptamine energy transmitter system, so that experimental basis is provided for the traditional Chinese medicine efficacy of soothing nerves and relieving depression.

3) Herba Hedyotidis Diffusae: is an annual herbaceous plant of genus Eupatorium of family Rubiaceae. Slightly bitter, sweet and cold in taste. It enters stomach, large intestine and small intestine meridians. Has the effects of clearing away heat and toxic materials, promoting diuresis and treating stranguria. Modern pharmacological studies show that the oldenlandia contains various chemical components such as anthraquinone, flavonoid, terpene and the like, and has the effects of resisting inflammation, resisting bacteria, resisting oxidation, regulating immunity, resisting tumors and the like.

4) Amber is a fossil-like substance obtained by resin-buried underground transformation of ancient Pinaceae plants such as maple and pine. Digging out from underground or coal bed, removing impurities such as sandstone and soil, mashing, and grinding into fine powder. Sweet and mild in taste. It enters heart, liver and bladder meridians. Has the effects of relieving convulsion, tranquilizing, promoting blood circulation, removing blood stasis, inducing diuresis, and treating stranguria. It can be used for treating restlessness, palpitation, insomnia, infantile convulsion, and epilepsy. The bibliography: ' governing five zang organs, calming soul, … … eliminating blood stasis, and dredging five stranguria. Modern pharmacological research shows that the amber contains resin, volatile oil, succinic acid and the like, and the succinic acid has pharmacological action of central inhibition.

5) The semen Ziziphi Spinosae is dry mature seed of Zizyphus jujube of Rhamnaceae. Sweet, sour and neutral in flavor. It enters heart, liver and gallbladder meridians. Has the efficacies of nourishing heart yin and benefiting liver blood, and is the essential drug for nourishing heart and soothing nerves. It can be used for treating palpitation, insomnia, spontaneous perspiration, night sweat, amnesia, and nocturnal emission. Shen nong Ben Cao Jing: the traditional Chinese medicine composition has the effects of controlling heart and abdomen cold and heat, pathogenic accumulation, soreness and pain of limbs and damp arthralgia, calming the five internal organs after long-term administration, and reducing weight and prolonging life. Its chemical components include spina date seed saponin, triterpenes, flavonoids, vitamin C, polysaccharide, phytosterol, etc. Pharmacological research shows that jujuboside, flavonoid glycoside, water and alcohol extract have sedative hypnotic and antiarrhythmic effects.

6) The bupleuri radix is dried root of Bupleurum scorzonerifolium or Bupleurum scorzonerifolium of Umbelliferae. Bitter, pungent and slightly cold in flavor. It enters liver and gallbladder meridians. Has the effects of relieving exterior syndrome, relieving fever, dispersing stagnated liver qi for relieving qi stagnation, and lifting yang qi. It is mainly used for treating exterior syndrome fever, shaoyang syndrome and stagnation of qi due to depression of the liver. Shen nong Ben Cao Jing: "governing qi accumulation in the stomach and intestines of heart, abdomen, food accumulation, pathogenic factors of cold and heat, old and new. Modern pharmacological research shows that bupleurum has a wide central inhibition effect of tranquilizing, calming, easing pain and the like.

7) Radix Paeoniae alba is root of Paeonia lactiflora pall of Ranunculaceae. Peeling, soaking in boiling water or decocting until it is heated, and sun drying. When used, the slices are moistened thoroughly. Unprocessed or stir-baked with wine or stir-baked with clear fire. Bitter and sour taste, slightly cold. It enters liver and spleen meridians. Has effects of nourishing blood, astringing yin, softening liver, relieving pain, and suppressing liver yang. It is mainly indicated for liver-spleen disharmony, liver blood deficiency and liver yang hyperactivity. Shen nong Ben Cao Jing: "governing pathogenic qi and abdominal pain", … … alleviating pain, inducing diuresis and tonifying qi. Modern pharmacological research shows that paeoniflorin contained in radix paeoniae alba has obvious effects of relieving pain and spasmolysis.

8) Radix Curcumae is root tuber of Curcuma wenyujin Y.H.Chen et C.Ling, Curcuma longa L.Chen et C.Ling, Curcuma kwangxi Zedoariae L.or Curcumae rhizoma etc. of Zingiberaceae. Pungent, bitter and cold in flavor. It enters liver, gallbladder and heart meridians. Has the effects of promoting blood circulation, relieving pain, promoting qi circulation, relieving depression, clearing away heart-fire, cooling blood, promoting bile flow, and eliminating jaundice. The materia Medica is in the future: promoting qi circulation, relieving depression, discharging blood, removing blood stasis. Cool heart heat, dispel liver depression … …. The pharmacological research shows that the curcuma aromatica has an inhibiting effect on various bacteria, and particularly has a stronger effect on gram-negative bacteria than on gram-positive bacteria. Yu jin also has anti-inflammatory and analgesic effects.

9) The cimicifugae rhizoma is dry rhizome of Cimicifuga racemosa, Cimicifuga dahurica or Cimicifuga racemosa of Ranunculaceae. Pungent, slightly sweet and slightly cold in flavor. It enters lung, spleen, stomach and large intestine meridians. Has the effects of relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang qi. It is mainly used for treating exterior syndrome due to exogenous pathogenic factors and sinking of qi due to deficiency. Pharmacological research shows that the cimicifuga foetida has moderate antibacterial effect on tubercle bacillus, staphylococcus aureus and catacoccus, and has certain inhibition effect on intestinal spasm caused by acetylcholine chloride, histamine and barium chloride.

10) The Glycyrrhrizae radix is root and rhizome of Leguminosae plant Glycyrrhrizae radix, radix Glycyrrhizae Inflatae or radix Glycytthizae. Sweet and mild in taste. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, eliminating phlegm and relieving cough, relieving spasm and pain, clearing away heat and toxic materials, and harmonizing the drugs. It can be used for treating heart and spleen qi deficiency, abdominal pain, etc. The book Ben Cao Hui Yan (treatise on materia Medica): herbs that regulate the middle warmer, tonify qi, tonify deficiency and remove toxicity are also included. The licorice contains triterpenes, flavonoids, alkaloid, polysaccharide and other components, and has the functions of resisting ulcer, inhibiting gastric acid secretion, relieving gastrointestinal smooth muscle spasm and relieving pain.

11) The white hyacinth bean is mature seed of leguminous plant hyacinth bean. Sweet and slightly warm in taste. It enters spleen and stomach meridians. Has effects in invigorating spleen, neutralizing and eliminating dampness. It is used for treating spleen qi deficiency syndrome and vomiting and diarrhea due to summer-heat and dampness. Compendium of materia Medica: it can relieve diarrhea and dysentery, relieve summer-heat, warm spleen and stomach … ….

12) Fructus Amomi is dry mature fruit of Zingiberaceae plant such as YANGCHUNSHA, LVHUSHA or Hainan SHA. Pungent and warm in flavor. It enters spleen, stomach and kidney meridians. Has effects of eliminating dampness, activating qi-flowing, warming spleen and stomach, relieving diarrhea, and preventing miscarriage. It is mainly indicated for qi stagnation of spleen and stomach and vomiting and diarrhea due to deficiency cold. The book of Kaibao Ben Cao: it is indicated for consumptive disease, dysentery with diarrhea, red and white diarrhea, abdominal pain and qi exhaustion. Pharmacological research shows that the decoction of the product has the functions of stimulating intestinal peristalsis and digestive juice secretion, thereby being helpful for digestion and eliminating intestinal flatulence symptoms.

13) The fructus evodiae is dried nearly mature fruit of Rutaceae plant fructus evodiae, caulis Seu folium Ampelopsis Brevipedunculatae or Rutaceae fructus evodiae. Pungent, bitter and hot; has little toxicity. It enters liver, spleen, stomach and kidney meridians. Has the effects of dispelling cold, relieving pain, lowering adverse qi, arresting vomiting, supporting yang, relieving diarrhea, etc. It can be used for treating diarrhea due to deficiency cold, emesis due to stomach cold, and pain due to congealing cold. Compendium of materia Medica: it is indicated for headache due to phlegm and saliva of jueyin, abdominal pain due to yin-toxicity, hernia and bloody dysentery, sore throat and tongue. Pharmacological research shows that the evodia rutaecarpa decoction has the effects of resisting experimental gastric ulcer and gastrointestinal spasm of animals and has obvious analgesic effect.

14) The pericarpium Granati is pericarp of Granati of Punicaceae. Sour, astringent and warm. It enters large intestine meridian. Has the effects of relieving diarrhea with astringents, killing parasites and stopping bleeding. It is used to treat chronic diarrhea, chronic dysentery, abdominal pain, etc. Compendium of materia Medica: "Xie Li, Xie Xue Xie, Fang anus, metrorrhagia middle-jiao leukorrhagia". The pomegranate bark contains 10.4-21.3% of tannin, and also contains punicaline, pseudo-punicaline, isopunicaline, N-methyl-isopomegranate bark, gallic acid, malic acid, ursolic acid, isoquercitrin, resin, mannitol, sugar and the like. The pericarp decoction has effect in killing Staphylococcus aureus, Shi and Shigella flexneri, and Bacillus diphtheriae; has obvious inhibiting effect on cholera vibrio, typhoid bacillus, pseudomonas aeruginosa, tubercle bacillus and the like.

15) Myristica fragrans Houtt is the mature kernel of Myristica fragrans Houtt, a family Myristicaceae. Pungent and warm in flavor. It enters spleen, stomach and large intestine meridians. Has the effects of astringing intestine to stop diarrhea, warming middle-jiao and promoting qi circulation. It can be used for treating diarrhea, cold dysentery, stomach cold, distending pain, anorexia, and emesis. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): the pungent flavor of nutmeg can dissipate and eliminate energy, warm qi and harmonize the middle-warmer, and has fragrant smell, the fragrance firstly enters the spleen, the spleen mainly digests, and the nutmeg is mild and spicy, so the nutmeg stimulates the appetite, and the stomach prefers to warm so the stomach is also warm. The nutmeg contains 5-15% of volatile oil. And nutmeg ether, eugenol, isoeugenol and various terpene compounds. The nutmeg contains volatile oil which can promote gastric secretion and gastrointestinal peristalsis, and has the effects of promoting appetite, relieving flatulence and relieving pain; the terpenoid component in the volatile oil has inhibitory effect on bacteria and mold.

16) The fructus Chebulae is mature fruit of Terminalia chebula Retz of Combretaceae. Bitter, sour, astringent and neutral. It enters lung and large intestine meridians. Has the effects of relieving diarrhea with astringents, astringing lung, relieving cough, relieving sore throat, and relieving sore throat. Mainly used for treating chronic diarrhea and chronic dysentery; chronic cough and aphonia. Ben Cao Jing Shu (the book of materia Medica Prime and Dredging): chebulae Leiller is bitter and astringent in taste and warm in nature without toxicity. Bitter flavor with diarrhea and astringent flavor with warm property with purgation, and astringing property with astringency with cold property with the effect of directing cold and fullness in the heart and abdomen; it can be eaten only because of its warm nature. The right of the physician's physician is to stop the water passage, the handle of the physician's tongue is to stop the chronic diarrhea of the intestine , the recipe of Su song is to treat the diarrhea and leukorrhagia due to the intestinal wind, the Zhu Zheng Heng is to strengthen the large intestine, there is no astringency, so the treatment effect is also indicated. The original menstrual period was: raw material used for clearing gold and relieving cough, roasted for consolidating spleen and checking diarrhea. Pharmacological research shows that the myrobalan decoction has an inhibiting effect on dysentery bacillus, pseudomonas aeruginosa, diphtheria bacillus, staphylococcus aureus, escherichia coli, pneumococcus, hemolytic streptococcus, proteus, typhus bacillus and the like. Terminalia chebula extract extracted from dried fruit with 80% ethanol has papaverine-like spasmolytic effect on smooth muscle.

EXAMPLE 1 Capsule

The embodiment of the invention provides a traditional Chinese medicine composition for treating diarrhea type IBS, which is prepared from the following raw material medicines: 1500g of lotus seed (containing lotus plumule); 1200g of silktree albizzia bark; 200g of amber powder; 1500g of spina date seeds; 600g of radix bupleuri; white peony root, radix Paeoniae alba 1500 g; turmeric root-tuber 10g 00; 1500g of oldenlandia diffusa; 900g of rhizoma cimicifugae, 900g of liquorice, 1200g of white hyacinth bean, 600g of fructus amomi, 300g of fructus evodiae, 1000g of pomegranate rind, 900g of nutmeg and 1000g of myrobalan

The preparation form of the traditional Chinese medicine composition is capsules, and the preparation method comprises the following steps:

a. weighing the medicines according to the weight, processing the medicines according to the procedures in the preparation method, adding 7 times of water to soak for 2 hours, extracting volatile oil for 5 hours, filtering the liquid medicine, and reserving the medicine residues for later use; wherein the volatile oil is extracted by supercritical extraction method;

b. b, adding ethanol with the alcohol degree of 75% into the medicine dregs obtained in the step a, soaking for 1 hour, extracting for 3 times, 2 hours each time, adding 10 times of the ethanol of the mixture in the first time, adding 10 times of the ethanol of the mixture in the second time, combining the extracting solutions, and filtering; mixing the above two filtrates, filtering, concentrating the filtrate under reduced pressure to relative density of 1.30 at 80 deg.C, precipitating with ethanol twice, adjusting ethanol concentration to 75%, collecting supernatant, and concentrating to relative density of 1.40 at 80 deg.C to obtain extract; wherein the extraction adopts membrane separation technology;

c. and c, mixing the extract obtained in the step b with volatile oil, grinding for 10 minutes by using a colloid mill, continuously stirring, cooling to room temperature to obtain a traditional Chinese medicine composition, and filling the traditional Chinese medicine composition into a capsule shell to obtain a capsule finished product.

EXAMPLE 2 tablets

The preparation form of the traditional Chinese medicine composition is tablets, and the preparation method comprises the following steps:

weighing the medicines according to the weight, processing the medicines according to the procedures in the preparation method, putting all the raw medicinal materials into 82% ethanol in an amount which is 10 times that of the medicines, heating and refluxing for two times, extracting active ingredients for 45 minutes each time, combining the two extracting solutions, standing to obtain an extracting solution I, and keeping dregs for later use; adding 10 times of water into the medicine residues, heating, refluxing and extracting for three times, wherein each time is 1 hour, and combining the three extracting solutions to obtain an extracting solution II; mixing the first extractive solution and the second extractive solution, recovering ethanol under reduced pressure, concentrating to obtain medicinal liquid with concentration of 0.5g crude drug/mL, and vacuum filtering to obtain filtrate with relative density of 1.08 at 20 deg.C; eluting the filtrate twice through a macroporous adsorption resin column with the volume of 10L, eluting with deionized water or distilled water with the volume of 10 times that of the resin column, eluting with 95% ethanol with the volume of 5 times that of the resin column, collecting ethanol eluate, and removing ethanol solvent to obtain raw material liquid medicine; adding starch, and making into tablet.

Example 3 decoction

The embodiment of the invention provides a traditional Chinese medicine composition for treating diarrhea type IBS, which is prepared from the following raw material medicines: 15g of lotus seeds (containing lotus plumule), 12g of cortex albiziae, 2g of amber powder, 15g of spina date seeds, 6g of radix bupleuri, 15g of white paeony roots, 10g of radix curcumae, 15g of oldenlandia diffusa, 9g of rhizoma cimicifugae, 9g of liquorice, 12g of white hyacinth beans, 6g of fructus amomi, 3g of fructus evodiae, 10g of pomegranate rind, 9g of nutmeg and 10g of myrobalan.

The Chinese medicinal composition is in the form of decoction, and the preparation method comprises the following steps:

weighing the medicines according to the weight, processing the medicines according to the procedures in the preparation method, mixing the medicines except the amber powder according to the formula proportion, soaking, decocting according to a conventional method to obtain a traditional Chinese medicine decoction, filtering dregs of a decoction, adding the amber powder, and stirring uniformly to obtain the traditional Chinese medicine decoction for taking.

5. The taking dosage is as follows: the decoction is one dose per day. The tablet and capsule preparation is taken at a dose of 1 g/day/person per day, and is equivalent to 6.0g crude drug/day/person according to crude drug amount.

6. Convincing experimental evidence (i.e. pharmacological experiments: including clinical experiments, animal experiments or in vitro experiments (microorganisms), etc.), experimental evidence providing specific experimental compounds, dosage, administration method, experimental method and calculation method for judging conclusion, etc.

1) Acute toxicity test: an acute toxicity test is carried out by using 42 NIH mice, with SPF level, half male and female, and the weight of 18-20 g. Mice were randomly divided into two groups of 20 mice each, control and dosing groups, fasted for 12 hours prior to the experiment; the capsule prepared in example 1 of the present invention was dissolved in water (concentration of 2.58g crude drug/ml, maximum concentration) and gavage was performed with a gavage volume of 5ml/kg (i.e., single administration dose of 12.9 crude drug/kg), the control group was administered with an equal amount of physiological saline 2 times a day with an interval of 6 hours, and after administration, observation was continued for 14 days, and the toxic reaction and death number of mice were recorded. The experimental results show that: compared with a control group, the mice have no obvious difference after administration, and the mice have normal general conditions, diet, drinking water and weight increase after continuous observation for 14 days in the experiment. The capsule LD50 of the invention is orally administrated to mice with a gastric lavage of more than 12.9 crude drugs/kg, and the maximum daily dosage is 25.8 crude drugs/kg/day. The clinical dosage of the traditional Chinese medicine is equivalent to 6.0g crude drug/day/person, the weight of an adult is measured by 60KG, and the average dosage of the traditional Chinese medicine is 0.1g crude drug/KG/day. According to the weight: the tolerance of the traditional Chinese medicine for oral gavage of mice (the average body weight is calculated by 20g) is 258 times of the clinical dosage. Therefore, the traditional Chinese medicine composition disclosed by the invention is low in acute toxicity and safe in clinical medication.

2) Clinical data:

general data I: 184 patients with diarrhea-type IBS treated in a hospital during 6 months-2016 12 months in 2014 were selected, 96 men, 88 women, and 26-67 years old. The groups were randomly divided into 4 groups, 1-3 treatment groups and a control group, 46 per group. The comparison of the difference of the patients in age, sex and disease condition has no statistical significance and is comparable.

II diagnostic criteria: reference to diagnostic criteria for diarrhea-predominant IBS "roman III diagnostic criteria" (2006):

(ii) recurrent episodes of abdominal pain or discomfort, for at least 3 days per month in the last 3 months, with 2 or more of the following symptoms:

② improvement of abdominal pain or discomfort symptoms after defecation (discomfort means discomfort of non-painful nature, above symptoms appear at least 6 months at diagnosis);

③ attack with defecation frequency change, more than 3 times per day;

and fourthly, outbreak of abnormal stool characters: paste-like feces or water-like feces;

psychological test: the assessment of mental health by questionnaires to detect anxiety, depression or other psychological disorders in the patient helps support diagnosis of the disorder;

sixthly, organic lesions such as intestinal cancer, ovarian cancer and the like are eliminated.

III, the curative effect standard is as follows:

refer to the consensus opinion on irritable bowel syndrome traditional Chinese medicine diagnosis and treatment (the division of spleen and stomach diseases, 2010) of the Chinese medical society. Firstly, healing: the symptoms disappear. Secondly, effect is displayed: the symptom is obviously improved, and the total integral reduction rate of the symptom is more than or equal to 80 percent. ③ effective: the total integral reduction rate of symptoms is more than or equal to 50 percent and less than 80 percent. Fourthly, invalidation: total integral reduction of symptoms was < 50%.

IV methods of treatment and therapeutic effects

The treatment groups are 3 treatment groups randomly, and the traditional Chinese medicine compositions of 1-3 different preparations of the invention are respectively used for treatment; the control group was treated with oral trimebutine maleate.

(1) Treatment group 1: the capsule of example 1 is administered to 46 patients twice a day, 0.5g is taken once, and 20 days is a course of treatment. After treatment, statistics shows that 18 patients are cured clinically, 22 patients are treated with obvious effect, and 6 patients are treated with effective effect. During the treatment period, no side effect caused by the medicine is found.

(2) Treatment group 2: the tablets of example 2 were administered to 46 patients 2 times a day, 0.5g once, and 20 days as a treatment course. After treatment, statistics shows that 16 patients are cured clinically, 23 patients are treated with obvious effect, and 7 patients are treated with effective effect. During the treatment period, no side effect caused by the medicine is found.

(3) Treatment group 3: the decoction of the embodiment 3 is used by 46 patients, one dose is taken by each person in 2 times, and 20 days are a treatment course. After treatment, statistics shows that 21 patients are cured clinically, 20 patients are treated with obvious effect, and 5 patients are treated with effective effect. During the treatment period, no side effect caused by the medicine is found.

(4) Control group: the patient in 46 cases takes trimebutine maleate (0.1 mg/tablet, manufactured by Hainanpril pharmaceutical Co., Ltd., national standard H20000390) 3 times a day, 0.1mg each time, and 20 days as a treatment course. After treatment, statistics shows that 11 patients are clinically cured, 19 patients are effectively treated, 12 patients are effectively treated, and 4 patients are not effective. During the treatment period, no side effect caused by the medicine is found.

And V, conclusion:

the clinical tests show that: compared with a control group, the clinical cure and significant efficiency of the traditional Chinese medicine composition of the embodiments 1 to 3 of the invention are obviously improved compared with the control group. The traditional Chinese medicine composition disclosed by the invention has a remarkable advantage for treating diarrhea type IBS.

It should be noted that the above-mentioned embodiments are only preferred embodiments of the present invention, and the present invention is not limited thereto, and although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications and equivalents can be made in the technical solutions described in the foregoing embodiments, or equivalents thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention. Although the present invention has been described with reference to the specific embodiments, it should be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention.

Claims

1. A traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome is characterized by being prepared from the following raw material medicines in parts by weight: 12-18 parts of lotus seeds; 10-15 parts of cortex albiziae; 1-4 parts of amber powder; 12-18 parts of spina date seeds; 4-8 parts of radix bupleuri; 12-18 parts of white peony root; 8-12 parts of curcuma aromatica; 12-18 parts of oldenlandia diffusa; 6-12 parts of cimicifugae foetidae, 6-12 parts of liquorice, 10-15 parts of white hyacinth beans, 4-8 parts of fructus amomi, 1-5 parts of fructus evodiae, 8-12 parts of pomegranate rind, 6-12 parts of nutmeg and 8-12 parts of myrobalan;

the lotus plumule is not removed from the lotus seed;

the processing method of the raw materials comprises the following steps:

1) honey-fried cimicifugae foetidae and licorice: diluting refined honey with boiled water at a ratio of 6:4, spraying into cimicifugae rhizoma or Glycyrrhrizae radix slice, stirring, placing into a stir-frying container, heating with an electric ceramic furnace at 800w power, taking out, cooling, and adding refined honey 30g per 100g cimicifugae rhizoma or Glycyrrhrizae radix slice;

2) parching semen Ziziphi Spinosae: parching semen Ziziphi Spinosae with slow fire until outer skin is swollen at 150 deg.C for 5 min;

3) stir-frying white hyacinth bean and pomegranate rind with sand: placing a proper amount of sand in a medicine frying pot, heating for 5 minutes under 2200w power by using an electric ceramic furnace, reducing the heating to 800w power, adding white hyacinth beans or pomegranate rinds, stir-frying, stopping fire when the medicinal materials become slightly yellow, continuously stir-frying by using the residual temperature of the sand until the surface is brown, screening out sandy soil, and mashing when in use;

4) processing bupleuri radix with vinegar; mixing the radix bupleuri green sheet with rice vinegar, mixing with 20g of rice vinegar per 100g of radix bupleuri green sheet, moistening thoroughly, placing in a pan, parching with slow fire, taking out, and cooling;

5) coating roasted nutmeg and myrobalan on the surface: moistening semen Myristicae or fructus Chebulae, wrapping with 3 layers of flour, adding into parched hot sand, parching at 180 deg.C for 20 min, taking out, sieving to remove sand, peeling, and cooling;

6) cortex Albizziae, Succinum powder, radix Paeoniae alba, radix Curcumae, herba Hedyotidis Diffusae, fructus evodiae, semen Nelumbinis and fructus Amomi, and semen Nelumbinis and fructus Amomi should be smashed.

2. The traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome according to claim 1, which is prepared from the following raw material medicines in parts by weight: 12-15 parts of lotus seeds; 10-12 parts of cortex albiziae; 1-2 parts of amber powder; 12-15 parts of spina date seeds; 4-6 parts of radix bupleuri; 12-15 parts of white peony root; 8-10 parts of curcuma aromatica; 12-15 parts of oldenlandia diffusa; 6-9 parts of cimicifugae foetidae, 6-9 parts of liquorice, 10-12 parts of white hyacinth beans, 4-6 parts of fructus amomi, 1-3 parts of fructus evodiae, 8-10 parts of pomegranate rind, 6-9 parts of nutmeg and 8-10 parts of myrobalan;

the lotus seed does not have lotus plumule.

3. The traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome according to claim 1, which is prepared from the following raw material medicines in parts by weight: 15-18 parts of lotus seeds; 12-15 parts of cortex albiziae; 2-4 parts of amber powder; 15-18 parts of spina date seeds; 6-8 parts of radix bupleuri; 15-18 parts of white peony root; 10-12 parts of curcuma aromatica; 15-18 parts of oldenlandia; 9-12 parts of cimicifugae foetidae, 9-12 parts of liquorice, 12-15 parts of white hyacinth beans, 6-8 parts of fructus amomi, 3-5 parts of fructus evodiae, 10-12 parts of pomegranate rind, 9-12 parts of nutmeg and 10-12 parts of myrobalan;

the lotus seed does not have lotus plumule.

4. The traditional Chinese medicine composition for treating irritable bowel syndrome with diarrhea according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition is prepared into decoction, tablets, granules, pills or oral liquid.

5. A Chinese medicinal preparation for treating diarrhea-predominant irritable bowel syndrome, which comprises the Chinese medicinal composition for treating diarrhea-predominant irritable bowel syndrome according to any one of claims 1 to 3.

6. The method for preparing a Chinese medicinal composition for treating irritable bowel syndrome with diarrhea according to claim 1, wherein except amber powder, the rest materials are mixed according to a formula ratio, soaked, decocted conventionally to obtain a Chinese medicinal decoction, and after the residue is filtered, amber powder is added, and the mixture is stirred uniformly to obtain the composition for administration.

7. The preparation method of the capsule of the traditional Chinese medicine composition for treating diarrhea-predominant irritable bowel syndrome according to claim 1, comprising:

a. soaking the Chinese medicinal composition in 7 times of water for 2 hr, extracting volatile oil for 5 hr, filtering the medicinal liquid, and collecting the residue; wherein the volatile oil is extracted by supercritical extraction method;

8. The preparation method of the traditional Chinese medicine composition tablet for treating diarrhea-predominant irritable bowel syndrome according to claim 1, comprising:

putting the traditional Chinese medicine composition into 82% ethanol which is 10 times the amount of the traditional Chinese medicine composition, heating and refluxing for two times, extracting active ingredients for 45 minutes each time, combining the two extracting solutions, standing to obtain an extracting solution I, and keeping dregs for later use; adding 10 times of water into the medicine residues, heating, refluxing and extracting for three times, wherein each time is 1 hour, and combining the three extracting solutions to obtain an extracting solution II; mixing the first extractive solution and the second extractive solution, recovering ethanol under reduced pressure, concentrating to obtain medicinal liquid with concentration of 0.5g crude drug/mL, and vacuum filtering to obtain filtrate with relative density of 1.08 at 20 deg.C; eluting the filtrate twice through a macroporous adsorption resin column with the volume of 10L, eluting with deionized water or distilled water with the volume of 10 times that of the resin column, eluting with 95% ethanol with the volume of 5 times that of the resin column, collecting ethanol eluate, and removing ethanol solvent to obtain raw material liquid medicine; adding starch, and making into tablet.

9. Use of the Chinese medicinal composition for treating diarrhea-predominant irritable bowel syndrome according to any one of claims 1 to 3 for the preparation of a medicament having efficacy of treating patients with coexisting anxiety and IBS.