CN113797302A - Traditional Chinese medicine composition for treating spontaneous abortion and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating spontaneous abortion and preparation method thereof Download PDF

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CN113797302A
CN113797302A CN202111294614.1A CN202111294614A CN113797302A CN 113797302 A CN113797302 A CN 113797302A CN 202111294614 A CN202111294614 A CN 202111294614A CN 113797302 A CN113797302 A CN 113797302A
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traditional chinese
spontaneous abortion
chinese medicine
medicine composition
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吕向东
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Zhejiang Yanghe Health Management Technology Co ltd
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Zhejiang Yanghe Health Management Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/744—Gardenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/89—Cyperaceae (Sedge family)
    • A61K36/8905—Cyperus (flatsedge)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention provides a traditional Chinese medicine composition for treating spontaneous abortion and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine composition for treating spontaneous abortion comprises the following raw materials: cortex Dictamni, herba Stachydis Japonicae, fructus Gardeniae, radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi. The traditional Chinese medicine composition is used together, and can regulate the problems of blood heat and insufficient yin blood of pregnant women on the basis of protecting liver, tonifying spleen and kidney, strengthening and soothing the nerves from deficiency to excess, thereby solving the disease of spontaneous abortion.

Description

Traditional Chinese medicine composition for treating spontaneous abortion and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating spontaneous abortion and a preparation method thereof.
Background
Habitual abortion is also called as habitual abortion in traditional Chinese medicine. The common cause of this disease is that the fetus is not excessive due to either insufficient endowment or weak constitution. The pathogenesis of the disease is mainly caused by kidney deficiency and fetal failure or kidney deficiency and fetal loss. In addition, it is also caused by deficiency of qi and blood, malnutrition of the fetus, yin deficiency, blood heat and heat damaging the fetus. Modern medicine considers that the causes of the diseases are corpus luteum insufficiency, hypothyroidism and the like. In the treatment method, formulas such as kidney tonifying and strengthening pill, Taishan rock powder and the like are commonly used in traditional Chinese medicine, progesterone is generally given to the modern medicine according to corpus luteum function deficiency, 10-20 mg is injected into the muscle every day, and the traditional Chinese medicine is applied from pregnancy signs to 10 weeks of pregnancy. In clinical practice, the traditional Chinese medicine therapy and progesterone injection have 20-30% of inefficiency.
Therefore, a traditional Chinese medicine capable of effectively treating spontaneous abortion is needed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating spontaneous abortion, and the traditional Chinese medicine composition has a good curative effect on habitual abortion.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating spontaneous abortion, which is simple.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
In one aspect, the embodiment of the present application provides a traditional Chinese medicine composition for treating spontaneous abortion, which comprises the following raw materials: cortex Dictamni, herba Stachydis Japonicae, fructus Gardeniae, radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine composition for treating spontaneous abortion, which comprises the following steps:
grinding fructus Gardeniae and parching to obtain fructus Gardeniae preparata; decocting fructus Gardeniae preparata, cortex Dictamni Radicis and herba Stachydis Japonicae in water to obtain filtrate, concentrating the filtrate into fluid extract 1, adding ethanol into fluid extract 1, standing, collecting supernatant, and concentrating again to obtain fluid extract 2; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, radix Glycyrrhizae, and rhizoma Cyperi, and pulverizing into fine powder; and mixing the clear paste 2 with the fine powder to prepare the traditional Chinese medicine composition.
Gardenia: bitter taste and cold nature. It enters heart, lung and triple energizer meridians. Cool blood and stop bleeding. Has effects in protecting liver, promoting function of gallbladder, lowering blood pressure, tranquilizing mind, stopping bleeding, and relieving swelling.
And (3) preparing cortex dictamni: bitter taste and cold nature. It enters spleen, stomach and bladder meridians. Clear heat and dry dampness, dispel wind and remove toxicity. Can be used for treating damp heat sore, yellow water dripping, eczema, rubella, scabies, sore, rheumatism, arthralgia due to wind-damp-heat, jaundice, and dark urine.
And (3) stachys: pungent in flavor and slightly warm in nature. It enters lung and stomach meridians. Clearing away heat and toxic material, relieving cough and sore throat, stopping bleeding and relieving swelling. It is mainly used for common cold, cutaneous disease, consumptive lung disease, pulmonary abscess, dizziness, pharyngalgia, menoxenia, hematemesis, hemoptysis, epistaxis, metrorrhagia, dysentery, stranguria and swelling and pain due to traumatic injury.
Turmeric root-tuber: pungent and bitter in flavor and cold in nature. It enters liver, heart and lung meridians. Move qi and remove blood stasis, clear heart fire and relieve depression, promote bile flow and cure jaundice. Can be used for treating amenorrhea, dysmenorrhea, abdominal distention, pricking pain, fever, unconsciousness, epilepsy, jaundice, and dark urine.
Green tangerine peel: bitter and pungent in flavor and warm in nature. It enters liver, gallbladder and stomach meridians. To soothe the liver, break qi, resolve stagnation and resolve stagnation. Can be used for treating chest and hypochondrium distending pain, hernia, breast nodule, mammary abscess, and abdominal pain due to food stagnation.
Pinellia ternata: pungent flavor and warm nature. It enters spleen, stomach and lung meridians. Dry dampness and resolve phlegm, check adverse rise of qi and arrest vomiting, relieve stuffiness and dissipate nodulation. Can be used for treating excessive phlegm, cough, asthma, dizziness, palpitation, dizziness, headache, emesis, nausea, chest distress, and globus hystericus.
Wheat: sweet taste, slightly cold nature and no toxicity. Enter heart, spleen and kidney meridians. Nourishing heart, tonifying kidney, removing heat, tonifying deficiency, strengthening skin, strengthening intestines and stomach, and strengthening strength. Can be used for treating hysteria, dysphoria, inflammation, diarrhea, carbuncle and swelling,
costustoot: pungent and bitter with warm nature. It enters spleen, stomach, large intestine, triple energizer and gallbladder meridians. Move qi and alleviate pain, invigorate spleen and promote digestion. Can be used for treating chest and abdominal pain, dysentery, tenesmus, dyspepsia, and anorexia.
Tribulus terrestris: pungent and bitter in flavor, slightly warm in nature, entering liver meridian. Calming the liver, relieving depression, promoting blood circulation, expelling pathogenic wind, improving eyesight, and relieving itching. Can be used for treating headache, vertigo, distending pain in chest and hypochondrium, milk occlusion, mammary abscess, conjunctival congestion, nebula, and rubella with pruritus.
Fructus amomi flower: pungent flavor and warm nature. It enters spleen, stomach and kidney meridians. Resolve dampness, stimulate appetite, warm spleen, check diarrhea, regulate qi and prevent abortion. Can be used for treating qi stagnation of spleen and stomach, abdominal distention, and nausea.
And (3) Sutou: pungent in flavor and warm in nature, entering lung and spleen meridians. Dispel wind and cold, dispel phlegm and direct qi downward. Can be used for treating cough, asthma, phlegm and fluid retention in chest, dizziness, body pain, nasal obstruction, and watery nasal discharge.
Arborvitae seed: sweet in flavor and neutral in nature. It enters heart, kidney and large intestine meridians. Nourish heart and induce tranquilization, stop sweating, moisten intestines. Can be used for treating vexation, insomnia, cardiopalmus, night sweat due to yin deficiency, and constipation due to intestinal dryness.
Licorice root: sweet in flavor and neutral in nature. It enters heart, lung, spleen and stomach meridians. Invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal distention, limb spasm, pain, carbuncle, suppurative sore, and relieving drug toxicity.
Rhizoma cyperi: pungent, slightly bitter, slightly sweet and neutral in nature. It enters liver, spleen and triple energizer meridians. Move qi and relieve depression, regulate menstruation and alleviate pain. Can be used for treating stagnation of qi due to depression of the liver, chest, hypochondrium, abdominal distention and pain, dyspepsia, chest and abdominal fullness and distention, hernia of cold type, abdominal pain, breast pain, menoxenia, amenorrhea, and dysmenorrhea.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the inventor thinks that the reasons for the unconsolidation of the fetal origin of the pregnant woman are excess and deficiency, the excess causes yang exuberance and blood heat to damage the fetal origin, the deficiency causes yin blood deficiency, yin deficiency and fire excess to burn the fetal origin, and the combination of the two causes habitual abortion. Therefore, the invention adopts the cortex dictamni and the stachys japonica for clearing heat and cooling blood, dispelling wind and removing toxicity, and matches with the scorched gardenia for reducing blood pressure and protecting liver, mainly treats blood heat on the basis of protecting the liver and kidney of pregnant women, and the cortex dictamni, the stachys japonica and the stachys japonica are monarch drugs; radix curcumae, costustoot and tribulus terrestris are used for promoting qi circulation and removing blood stasis, and activating blood and dispelling wind, and green tangerine peel is used for removing food retention and resolving stagnation, pinellia is used for relieving distension and fullness and dissipating stagnation, and the assistant monarch drugs are used for playing the effects of calming the liver and resolving depression, and promoting qi circulation and dissipating stagnation, and are used as ministerial drugs together; the perilla head, the villous amomum fruit flower, the wheat and the platycladi seed are matched to play the effects of warming spleen and promoting appetite, tonifying deficiency and soothing nerves, strengthen the body of a parent body and serve as adjuvant drugs; finally, liquorice is used for blending, and rhizoma cyperi is used for guiding the medicines to the focus of infection as a guiding medicine. The traditional Chinese medicine composition is used together, and can regulate the problems of blood heat and insufficient yin blood of pregnant women on the basis of protecting liver, tonifying spleen and kidney, strengthening and soothing nerves from deficiency to excess, thereby solving the disease of spontaneous abortion.
The preparation method is simple, has obvious effect and has good social benefit.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
Pulverizing fructus Gardeniae, parching with middle fire until the surface turns brown or black, and the inner surface of pericarp and seed surface turn brown or brown, taking out, and cooling.
A traditional Chinese medicine composition for treating spontaneous abortion comprises the following raw materials: cortex Dictamni, herba Stachydis Japonicae, fructus Gardeniae, radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi.
In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 20-40 parts of cortex dictamni, 25-40 parts of stachys japonica, 30-45 parts of scorched gardenia, 10-18 parts of radix curcumae, 6-18 parts of elecampane, 8-18 parts of tribulus terrestris, 8-15 parts of green tangerine peel, 8-15 parts of pinellia ternate, 5-10 parts of perilla head, 5-12 parts of villous amomum flower, 3-8 parts of wheat, 3-8 parts of platycladi seed, 2-5 parts of liquorice and 2-5 parts of rhizoma cyperi.
In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 25-35 parts of cortex dictamni, 30-40 parts of stachys japonica, 35-42 parts of scorched gardenia, 12-15 parts of radix curcumae, 8-15 parts of elecampane, 10-15 parts of tribulus terrestris, 10-14 parts of green tangerine peel, 10-15 parts of pinellia ternate, 5-8 parts of perilla head, 5-8 parts of villous amomum flower, 3-5 parts of wheat, 3-5 parts of platycladi seed, 3-5 parts of liquorice and 2-3 parts of rhizoma cyperi.
In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 30 parts of cortex dictamni, 35 parts of stachys japonica, 40 parts of scorched gardenia, 13 parts of radix curcumae, 10 parts of elecampane, 10 parts of tribulus terrestris, 10 parts of green tangerine peel, 12 parts of pinellia ternate, 6 parts of perilla head, 7 parts of villous amomum flower, 4 parts of wheat, 4 parts of platycladi seed, 4 parts of liquorice and 3 parts of rhizoma cyperi.
A preparation method of a traditional Chinese medicine composition for treating spontaneous abortion comprises the following steps:
grinding fructus Gardeniae and parching to obtain fructus Gardeniae preparata;
decocting fructus Gardeniae preparata, cortex Dictamni Radicis and herba Stachydis Japonicae in water to obtain filtrate, concentrating the filtrate into fluid extract 1, adding ethanol into fluid extract 1, standing, collecting supernatant, and concentrating again to obtain fluid extract 2;
oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, radix Glycyrrhizae, and rhizoma Cyperi, and pulverizing into fine powder;
mixing the fluid extract 2 and the fine powder to prepare the traditional Chinese medicine composition.
The traditional Chinese medicine composition can be prepared into medical universal dosage forms such as tablets, pills, granules, capsules and the like.
In some embodiments of the present invention, the stir-frying process of the scorched gardenia comprises: pulverizing fructus Gardeniae into powder, placing in a hot pan, parching with middle fire to brown, taking out, and cooling.
In some embodiments of the present invention, the above-mentioned decocting with water specifically comprises: adding clear water with the weight 10-15 times that of the raw materials into the scorched gardenia, the dittany bark and the stachys sieboldii, decocting for 2-3 hours, pouring out the liquid medicine, adding water into the residual medicine residues again for decocting, merging the liquid medicine after 2-3 times of decocting, and filtering to obtain the filtrate.
In some embodiments of the invention, the relative density of the fluid extract 1 at 50-60 ℃ is 1.1-1.3, and the relative density of the fluid extract 2 at 50-60 ℃ is 1.05-1.2.
In some embodiments of the invention, the mass fraction of the ethanol is 80-85%, and the mass ratio of the clear paste 1 to the ethanol is 1: (1-1.5).
In some embodiments of the present invention, the fine powder has a particle size of 200 to 400 mesh.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A Chinese medicinal composition for treating spontaneous abortion comprises: 30g of dittany bark, 35g of stachys, 40g of scorched gardenia, 13g of turmeric root-tuber, 10g of costustoot, 10g of tribulus terrestris, 10g of green tangerine orange peel, 12g of pinellia tuber, 6g of perilla head, 7g of villous amomum flower, 4g of wheat, 4g of platycladi seed, 4g of liquorice and 3g of nutgrass galingale rhizome.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding 12 times of water by mass into the scorched gardenia, the densefruit pittany root-bark and the stachys sieboldii, decocting for 2 hours, pouring out the first decocted liquid medicine, adding 10 times of water by mass into the remained medicine residues, decocting for 2 hours again, pouring out the second decocted liquid medicine, mixing the first decocted liquid medicine and the second decocted liquid medicine to obtain filtrate, concentrating the filtrate into clear paste 1 with the relative density of 1.2, adding 85% ethanol with the same mass into the clear paste 1, standing for 2 hours, taking the supernatant, and concentrating again to obtain clear paste 2 with the relative density of 1.1; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 30 deg.C for 30min, taking out, and pulverizing into 200 mesh fine powder; mixing the clear paste 2 with the fine powder, and preparing into pills to obtain the traditional Chinese medicine composition of the embodiment.
The use method comprises the following steps: 10g each time, 1 time each day in the morning and evening, from the discovery of early pregnancy to three months of pregnancy. During the administration period, the people pay attention to diet nutrition, keep the mood smooth, avoid excessive fatigue and forbid sexual life.
Example 2
A Chinese medicinal composition for treating spontaneous abortion comprises: 35g of dittany bark, 40g of stachys, 42g of scorched gardenia, 15g of turmeric root-tuber, 15g of costustoot, 12g of tribulus terrestris, 13g of green tangerine peel, 10g of pinellia tuber, 5g of perilla head, 5g of villous amomum flower, 5g of wheat, 3g of platycladi seed, 5g of liquorice and 3g of cyperus rotundus.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding 11 times of water by mass into the scorched gardenia, the cortex dictamni and the stachys, decocting for 3 hours, pouring out the first decocted liquid medicine, reserving the medicine dregs, adding 15 times of water by mass again, decocting for 2.5 hours again, pouring out the second decocted liquid medicine, mixing the first decocted liquid medicine and the second decocted liquid medicine to obtain a filtrate, concentrating the filtrate into a clear paste 1 with the relative density of 1.3, adding 1.5 times of 80% ethanol by mass into the clear paste 1, standing for 3 hours, taking the supernatant, and concentrating again to obtain a clear paste 2 with the relative density of 1.05; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 35 deg.C for 40min, taking out, and pulverizing into 300 mesh fine powder; mixing the clear paste 2 with the fine powder, and pressing into tablets to obtain the traditional Chinese medicine composition of the embodiment.
Example 3
A Chinese medicinal composition for treating spontaneous abortion comprises: 25g of dittany bark, 30g of stachys, 35g of scorched gardenia, 12g of turmeric root-tuber, 8g of costustoot, 15g of tribulus terrestris, 14g of green tangerine peel, 15g of pinellia tuber, 8g of perilla head, 8g of villous amomum flower, 3g of wheat, 5g of platycladi seed, 3g of liquorice and 2g of nutgrass galingale rhizome.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding 13 times of water by mass into the scorched gardenia, the densefruit pittany root-bark and the stachys sieboldii, decocting for 2 hours, pouring out the first decocted liquid medicine, reserving dregs of a decoction, adding 12 times of water by mass again, decocting for 3 hours again, pouring out the second decocted liquid medicine, reserving dregs of a decoction, adding 10 times of water by mass again, decocting for 2 hours again, pouring out the third decocted liquid medicine, mixing the first decocted liquid medicine, the second decocted liquid medicine and the third decocted liquid medicine to obtain a filtrate, concentrating the filtrate into a clear paste 1 with the relative density of 1.2, adding 80% of ethanol with the same mass into the clear paste 1, standing for 3 hours, taking the supernatant, and concentrating again to obtain a clear paste 2 with the relative density of 1.1; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 35 deg.C for 50min, taking out, and crushing into 400 mesh fine powder; mixing the clear paste 2 with the fine powder, and preparing into granules to obtain the traditional Chinese medicine composition of the embodiment.
Example 4
A Chinese medicinal composition for treating spontaneous abortion comprises: 40g of dittany bark, 25g of stachys, 45g of scorched gardenia, 18g of turmeric root-tuber, 6g of costustoot, 8g of tribulus terrestris, 8g of green tangerine orange peel, 15g of pinellia tuber, 5g of perilla head, 5g of villous amomum flower, 8g of wheat, 3g of platycladi seed, 5g of liquorice and 2g of nutgrass galingale rhizome.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding 12 times of water by mass into the scorched gardenia, the densefruit pittany root-bark and the stachys sieboldii, decocting for 3 hours, pouring out the first decocted liquid medicine, adding 14 times of water by mass into the remained medicine residues, decocting for 3 hours again, pouring out the second decocted liquid medicine, mixing the first decocted liquid medicine and the second decocted liquid medicine to obtain filtrate, concentrating the filtrate into a clear paste 1 with the relative density of 1.1, adding 80% ethanol with the same mass into the clear paste 1, standing for 4 hours, taking the supernatant, and concentrating again to obtain a clear paste 2 with the relative density of 1.2; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 32 deg.C for 30min, taking out, and pulverizing into 300 mesh fine powder; mixing the clear paste 2 with the fine powder, and preparing into pills to obtain the traditional Chinese medicine composition of the embodiment.
Example 5
A Chinese medicinal composition for treating spontaneous abortion comprises: 20g of dittany bark, 40g of stachys, 30g of scorched gardenia, 10g of turmeric root-tuber, 18g of costustoot, 18g of tribulus terrestris, 15g of green tangerine peel, 8g of pinellia tuber, 10g of perilla head, 5g of villous amomum flower, 3g of wheat, 8g of platycladi seed, 2g of liquorice and 5g of nutgrass galingale rhizome.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding 11 times of water by mass into the scorched gardenia, the cortex dictamni and the stachys, decocting for 3 hours, pouring out the first decocted liquid medicine, adding 10 times of water by mass into the remained medicine residues, decocting for 3 hours again, pouring out the second decocted liquid medicine, mixing the first decocted liquid medicine and the second decocted liquid medicine to obtain a filtrate, concentrating the filtrate into a clear paste 1 with the relative density of 1.3, adding 80% ethanol with the same mass into the clear paste 1, standing for 4 hours, taking the supernatant, and concentrating again to obtain a clear paste 2 with the relative density of 1.05; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 32 deg.C for 35min, taking out, and crushing into 350 mesh fine powder; mixing the clear paste 2 with the fine powder, and preparing into pills to obtain the traditional Chinese medicine composition of the embodiment.
Example 6
A Chinese medicinal composition for treating spontaneous abortion comprises: 50g of cortex dictamni, 25g of stachys, 35g of scorched gardenia, 8g of radix curcumae, 12g of elecampane, 11g of tribulus terrestris, 16g of green tangerine peel, 10g of pinellia ternate, 8g of perilla head, 8g of villous amomum flower, 2g of wheat, 5g of platycladi seed, 2g of liquorice and 2g of nutgrass galingale rhizome.
The preparation method comprises the following steps: crushing clean gardenia into crushed slag, putting the crushed slag into a hot pot, frying the crushed clean gardenia with medium fire to make the surface of the crushed clean gardenia brown, taking out the crushed clean gardenia and cooling the roasted gardenia after the inner surface of a peel and the surface of seeds are yellow brown or tan; adding water with the mass of 10 times into the scorched gardenia, the cortex dictamni and the stachys, decocting for 3 hours, pouring out the liquid medicine decocted for the first time, adding water with the mass of 13 times into the residual medicine dregs, decocting for 3 hours again, pouring out the liquid medicine decocted for the second time, mixing the liquid medicine decocted for the first time and the liquid medicine decocted for the second time to obtain filtrate, concentrating the filtrate into a clear paste 1 with the relative density of 1.2, adding 80% ethanol with the same mass into the clear paste 1, standing for 4 hours, taking the supernatant, and concentrating again to obtain a clear paste 2 with the relative density of 1.1; oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi at 30 deg.C for 35min, taking out, and pulverizing into 400 mesh fine powder; mixing the clear paste 2 with the fine powder, and preparing into pills to obtain the traditional Chinese medicine composition of the embodiment.
Comparative example 1
The comparative example differs from example 1 in that it uses gardenia which has not been roasted.
Comparative example 2
This comparative example differs from example 1 in that no gardenia was added.
Examples of the experiments
(ii) toxicity test
35 healthy experimental mice with the weight of 18 +/-2 g are adopted and randomly divided into 7 groups, wherein the experimental groups 1-6 are intragastrically infused by adopting the traditional Chinese medicine composition prepared in the embodiments 1-6 of the invention for 1 time every day and continuously for 3 months, and the experimental group 7 is a blank experimental group. The observation of the diet, water intake, urination, mental status, weight gain and other conditions of the animals during the test period is normal; after 90 days, one of the mice in each experimental group is respectively selected for dissection, hematology and blood biochemistry indexes are checked, organs such as heart, liver, spleen, lung, kidney, testis (epididymis), ovary, uterus, duodenum, brain, adrenal gland, thyroid gland and thymus of the animal are dissected and weighed immediately after blood collection, and organ weight coefficients (organ coefficients) are calculated according to body weight. The change of the viscera is observed by naked eyes, then the viscera is fixed by 10 percent formaldehyde solution, the tissue section of the viscera is made, the pathological and histological changes of the viscera are examined by a microscope, and the influence of the immunopotentiator on the liver and kidney functions of the rat is observed without obvious abnormality. Therefore, the traditional Chinese medicine composition has higher safety in clinical application.
(II) clinical trials
176 patients with a history of spontaneous abortion were admitted to the hospital from 10 months to date in 2015, and the age was 21-35 years old.
Diagnostic criteria: spontaneous abortion occurs 3 or more times in succession, and it behaves as general abortion and can be divided into early and late abortion, with early abortion occurring before 12 weeks gestation and late abortion after 12 weeks gestation. The clinical symptoms are that little bleeding occurs in the vagina in the early stage, or slight lower abdominal dull pain occurs, the bleeding can last for days or weeks, and the blood volume is low. In late stage abortion, vaginal bleeding increases, abdominal pain worsens, and abortion is inevitable when the cervical orifice is already dilated and even the cervical orifice is blocked by a fetal bundle.
The patients were divided into 8 groups according to the treatment time of the hospital, wherein the results of the groups 1-6 taking the Chinese medicinal composition prepared in the embodiments 1-6 of the present invention and the groups 7-8 taking the Chinese medicinal composition prepared in the embodiments 1-6 of the present invention are shown in table 1.
Standard of efficacy assessment the standard of efficacy:
and (3) healing: clinical symptoms disappeared, embryos developed normally by B-ultrasonic examination, and pregnancy reached more than 28 weeks by follow-up, or normal infants had been delivered.
The effect is shown: the clinical symptoms are obviously relieved, the embryo development is normal by B ultrasonic examination, and the gestation period is more than 28 weeks.
And (4) invalidation: after treatment, the clinical symptoms are unchanged or worsened, and the B-ultrasonic examination of the embryo stops or develops poor hair growth, and the embryo is aborted in the original gestational month or the pregnancy is terminated before 28 weeks.
Total effective rate (recovery + significant effect)/total number x 100%.
TABLE 1
Figure BDA0003336164820000121
Figure BDA0003336164820000131
As can be seen from Table 1, the Chinese medicinal composition prepared in the embodiments 1 to 6 of the present invention has a good therapeutic effect on patients who have suffered from spontaneous abortion or have constitutions resulting from spontaneous abortion. The effect difference between the comparative example 1 and the comparative example 2 is small, and the effective rate is obviously lower than that of the experimental groups 1-6.
Typical case 1, Zhangyi, woman, age 29, nurse in Hospital, pregnancy two and a half months after marriage, i.e. vaginal bleeding, abortion which is ineffective by using a traditional tocolysis method, second fetus after age 32, bleeding again after three months, and finally normal boy produced by the hospital after recuperation by the formula of example 1.
Typical cases 2, Liu is certain, women are 35 years old, and are miscarriage after marriage, the birth confidence is lost when the pregnancy lasts 40-60 days, the traditional Chinese medicine conditioning is carried out in a hospital immediately after the pregnancy, the formula of the invention in the embodiment 2 is taken from 35 days of the pregnancy until the pregnancy lasts for 3 months, the B-ultrasonography prompts that the fetus grows normally, the curative effect is consolidated after the fetus continues to be taken for 2 months, and finally a woman in the middle of birth is produced.
In conclusion, the embodiment of the invention provides a traditional Chinese medicine composition for treating spontaneous abortion and a preparation method thereof. The inventor thinks that the reasons for the unconsolidation of the fetal origin of the pregnant woman are excess and deficiency, the excess causes yang exuberance and blood heat to damage the fetal origin, the deficiency causes yin blood deficiency, yin deficiency and fire excess to burn the fetal origin, and the combination of the two causes habitual abortion. Therefore, the invention adopts the cortex dictamni and the stachys japonica for clearing heat and cooling blood, dispelling wind and removing toxicity, and matches with the scorched gardenia for reducing blood pressure and protecting liver, mainly treats blood heat on the basis of protecting the liver and kidney of pregnant women, and the cortex dictamni, the stachys japonica and the stachys japonica are monarch drugs; radix curcumae, costustoot and tribulus terrestris are used for promoting qi circulation and removing blood stasis, and activating blood and dispelling wind, and green tangerine peel is used for removing food retention and resolving stagnation, pinellia is used for relieving distension and fullness and dissipating stagnation, and the assistant monarch drugs are used for playing the effects of calming the liver and resolving depression, and promoting qi circulation and dissipating stagnation, and are used as ministerial drugs together; the perilla head, the villous amomum fruit flower, the wheat and the platycladi seed are matched to play the effects of warming spleen and promoting appetite, tonifying deficiency and soothing nerves, strengthen the body of a parent body and serve as adjuvant drugs; finally, liquorice is used for blending, and rhizoma cyperi is used for guiding the medicines to the focus of infection as a guiding medicine. The traditional Chinese medicine composition is used together, and can regulate the problems of blood heat and insufficient yin blood of pregnant women on the basis of protecting liver, tonifying spleen and kidney, strengthening and soothing nerves from deficiency to excess, thereby solving the disease of spontaneous abortion.
The preparation method is simple, has obvious effect and has good social benefit.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. A traditional Chinese medicine composition for treating spontaneous abortion is characterized by comprising the following raw materials: cortex Dictamni, herba Stachydis Japonicae, fructus Gardeniae, radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, Glycyrrhrizae radix and rhizoma Cyperi.
2. The traditional Chinese medicine composition for treating spontaneous abortion of claim 1, comprising the following raw materials in parts by weight: 20-40 parts of cortex dictamni, 25-40 parts of stachys japonica, 30-45 parts of scorched gardenia, 10-18 parts of radix curcumae, 6-18 parts of elecampane, 8-18 parts of tribulus terrestris, 8-15 parts of green tangerine peel, 8-15 parts of pinellia ternate, 5-10 parts of perilla head, 5-12 parts of villous amomum flower, 3-8 parts of wheat, 3-8 parts of platycladi seed, 2-5 parts of liquorice and 2-5 parts of rhizoma cyperi.
3. The traditional Chinese medicine composition for treating spontaneous abortion of claim 1, comprising the following raw materials in parts by weight: 25-35 parts of cortex dictamni, 30-40 parts of stachys japonica, 35-42 parts of scorched gardenia, 12-15 parts of radix curcumae, 8-15 parts of elecampane, 10-15 parts of tribulus terrestris, 10-14 parts of green tangerine peel, 10-15 parts of pinellia ternate, 5-8 parts of perilla head, 5-8 parts of villous amomum flower, 3-5 parts of wheat, 3-5 parts of platycladi seed, 3-5 parts of liquorice and 2-3 parts of rhizoma cyperi.
4. The traditional Chinese medicine composition for treating spontaneous abortion of claim 1, comprising the following raw materials in parts by weight: 30 parts of cortex dictamni, 35 parts of stachys japonica, 40 parts of scorched gardenia, 13 parts of radix curcumae, 10 parts of elecampane, 10 parts of tribulus terrestris, 10 parts of green tangerine peel, 12 parts of pinellia ternate, 6 parts of perilla head, 7 parts of villous amomum flower, 4 parts of wheat, 4 parts of platycladi seed, 4 parts of liquorice and 3 parts of rhizoma cyperi.
5. A method for preparing the Chinese medicinal composition for treating spontaneous abortion as claimed in any of claims 1-4, comprising the following steps:
grinding fructus Gardeniae and parching to obtain fructus Gardeniae preparata;
decocting fructus Gardeniae preparata, cortex Dictamni Radicis and herba Stachydis Japonicae in water to obtain filtrate, concentrating the filtrate into fluid extract 1, adding ethanol into fluid extract 1, standing, collecting supernatant, and concentrating again to obtain fluid extract 2;
oven drying radix Curcumae, radix aucklandiae, fructus Atriplicis Sibiricae, pericarpium Citri Reticulatae viride, rhizoma Pinelliae, fructus Perillae, flos Amomi, semen Tritici Aestivi, semen Platycladi, radix Glycyrrhizae, and rhizoma Cyperi, and pulverizing into fine powder;
and mixing the clear paste 2 with the fine powder to prepare the traditional Chinese medicine composition.
6. The method for preparing a Chinese medicinal composition for treating spontaneous abortion as claimed in claim 5, wherein the parching process of fructus Gardeniae preparata comprises: pulverizing fructus Gardeniae into powder, placing in a hot pan, parching with middle fire to brown, taking out, and cooling.
7. The method for preparing a Chinese medicinal composition for treating spontaneous abortion as claimed in claim 5, wherein the decocting with water comprises: adding clear water with the weight 10-15 times that of the raw materials into the scorched gardenia, the dittany bark and the stachys sieboldii, decocting for 2-3 hours, pouring out the liquid medicine, adding water into the residual medicine residues again for decocting, merging the liquid medicine after 2-3 times of decocting, and filtering to obtain the filtrate.
8. The preparation method of the traditional Chinese medicine composition for treating spontaneous abortion, as claimed in claim 5, wherein the relative density of the fluid extract 1 at 50-60 ℃ is 1.1-1.3, and the relative density of the fluid extract 2 at 50-60 ℃ is 1.05-1.2.
9. The preparation method of the traditional Chinese medicine composition for treating spontaneous abortion, as claimed in claim 5, wherein the mass fraction of ethanol is 80-85%, and the mass ratio of the added fluid extract 1 to ethanol is 1: (1-1.5).
10. The method for preparing a Chinese medicinal composition for treating spontaneous abortion of claim 5, wherein the fine powder has a particle size of 200-400 mesh.
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