CN114767809A - A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method - Google Patents
A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and its preparation method Download PDFInfo
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- CN114767809A CN114767809A CN202210493326.7A CN202210493326A CN114767809A CN 114767809 A CN114767809 A CN 114767809A CN 202210493326 A CN202210493326 A CN 202210493326A CN 114767809 A CN114767809 A CN 114767809A
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Abstract
The invention provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, and relates to the technical field of traditional Chinese medicine compositions. A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials in parts by weight: 38-60 parts of madder, 40-65 parts of combined spicebush root, 15-30 parts of safflower, 15-25 parts of polygonum orientale root, 12-18 parts of astragalus membranaceus, 10-15 parts of henbane, 8-15 parts of alpinia katsumadai, 5-10 parts of star anise, 5-10 parts of allium macrostemon, 5-10 parts of mussel, 4-8 parts of storax, 5-8 parts of tabasheer, 2-5 parts of liquorice, 1-3 parts of rhizoma acori graminei, 1-3 parts of rhizoma cibotii and 1-3 parts of fructus viticis. The invention has reasonable medicine use and combination of various medicines, and can play a role in treating both symptoms and root causes of cardiovascular and cerebrovascular diseases.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions, and in particular relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof.
Background
The cardiovascular and cerebrovascular diseases refer to diseases of heart ischemia or hemorrhage caused by arteriosclerosis of heart and artery, including coronary heart disease, angina pectoris, hypertension, arrhythmia, myocardial infarction, cerebral infarction, etc. Cardiovascular and cerebrovascular diseases are always called as the first killer threatening human health, and hypertension, hyperlipidemia, coronary heart disease and diabetes become epidemic of the times.
At present, the medicines for treating cardiovascular and cerebrovascular diseases have various varieties, but all have large side effects, and the individual medicine selection suitability is difficult to control. The cardiovascular and cerebrovascular diseases can be divided into cranial nerve pain, cardiac pain and limb weakness according to different causes and clinical manifestations, the traditional Chinese medicine considers that blood circulation is poor mostly, the current situation of preventing and treating the cardiovascular and cerebrovascular diseases is still not optimistic at present, the treatment effect of the commercially available traditional Chinese medicine is poor, the treatment period is long, the western medicine treatment method is mostly used, the western medicine treatment method for the cardiovascular and cerebrovascular diseases usually adopts treatment means such as placing a bracket in the heart, bridging and lifelong medicine taking, the treatment cost is high, the side effect is great, and the body and the heart of patients are greatly injured in the treatment process.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine composition for treating the cardiovascular and cerebrovascular diseases, and the traditional Chinese medicine composition has good curative effect on the cardiovascular and cerebrovascular diseases.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, which is simple and easy to operate.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, which comprises the following raw materials in parts by weight: 38-60 parts of madder, 40-65 parts of combined spicebush root, 15-30 parts of safflower, 15-25 parts of orientvine root, 12-18 parts of astragalus membranaceus, 10-15 parts of henbane, 8-15 parts of katsumade galangal seed, 5-10 parts of star anise, 5-10 parts of allium macrostemon, 5-10 parts of mussel, 4-8 parts of storax, 5-8 parts of tabasheer, 2-5 parts of liquorice, 1-3 parts of grassleaf sweelflag rhizome, 1-3 parts of rhizoma cibotii and 1-3 parts of fructus viticis.
On the other hand, the embodiment of the application provides a preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, which comprises the following steps:
grinding radix Rubiae and radix Linderae into fine powder to obtain radix Rubiae powder and radix Linderae powder;
crushing Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae, and extracting with water to obtain extractive solution;
mixing Mel and the extractive solution, heating and refining to obtain refined Mel;
mixing refined honey with the madder powder and the combined spicebush root powder to obtain the traditional Chinese medicine composition.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
according to clinical manifestations, cardiovascular diseases are called "syncope", "hemiparalysis", "stroke", "chest stuffiness" or "heartache" in traditional Chinese medicine. According to the invention, the madder has the effects of removing blood stasis and stimulating the menstrual flow, is cool in nature and can cool blood to clear away the heart fire and calm the nerves, the combined spicebush root has the effects of guiding qi downward and dispelling cold, and simultaneously has the effects of exciting cerebral cortex, promoting respiration, exciting cardiac muscle and vasodilatation, increasing fibrinolysis and reducing plasma viscosity, and the two medicines can remove blood stasis and promote menstruation while dilating blood vessels, and are monarch medicines together; safflower is adopted to improve myocardial ischemia, polygonum orientale root promotes tissue regeneration, promotes new angiogenesis and establishes collateral circulation, astragalus is matched to tonify qi and raise yang, henbane and alpinia katsumadai seed promote qi circulation and remove stagnation, so that whole blood is driven to run and metabolize, and monarch drugs are assisted to play a better effect, and are used as ministerial drugs together; adopts star anise to warm yang, allium macrostemon to dissipate stagnation and mussel to tonify deficiency and consolidate the body, and adopts storax and tabasheer to induce resuscitation and refresh mind to assist the dutchmanspipe stem to sooth the liver and relieve depression as adjuvant drugs; finally, liquorice is used for blending, and the rhizoma acori graminei, the rhizoma cibotii and the fructus viticis are used for guiding the medicines to directly reach the focus of infection and serve as guiding medicines. The invention has reasonable medicine use and combination of various medicines, and can play a role in treating both symptoms and root causes of cardiovascular and cerebrovascular diseases.
The invention grinds the madder and the combined spicebush root into fine powder, extracts other raw materials by water extraction, mixes the extracted liquid with honey after refining, and prepares pills or granules, wherein the effective components are high, the treatment effect can be improved, and the treatment period is shortened.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials in parts by weight: 38-60 parts of madder, 40-65 parts of combined spicebush root, 15-30 parts of safflower, 15-25 parts of polygonum orientale root, 12-18 parts of astragalus membranaceus, 10-15 parts of henbane, 8-15 parts of alpinia katsumadai, 5-10 parts of star anise, 5-10 parts of allium macrostemon, 5-10 parts of mussel, 4-8 parts of storax, 5-8 parts of tabasheer, 2-5 parts of liquorice, 1-3 parts of rhizoma acori graminei, 1-3 parts of rhizoma cibotii and 1-3 parts of fructus viticis.
In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 45-55 parts of madder, 50-60 parts of combined spicebush root, 15-20 parts of safflower, 15-20 parts of polygonum orientale root, 12-15 parts of astragalus membranaceus, 12-15 parts of henbane, 10-15 parts of katsumade galangal seed, 5-8 parts of star anise, 5-8 parts of allium macrostemon, 6-9 parts of mussel, 5-8 parts of storax, 5-6 parts of tabasheer, 2-3 parts of liquorice, 1-2 parts of grassleaf sweelflag rhizome, 2-3 parts of rhizoma cibotii and 1-2 parts of fructus viticis.
In some embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials by weight: 50 parts of madder, 55 parts of combined spicebush root, 18 parts of safflower, 18 parts of oriental smartweed root, 13 parts of astragalus, 13 parts of henry stegia, 10 parts of alpinia katsumadai, 6 parts of star anise, 6 parts of allium macrostemon, 7 parts of mussel, 6 parts of storax, concretio silicea bambusae, 5 parts of concretio silicea bambusae, 3 parts of liquorice, 2 parts of rhizoma acori graminei, 3 parts of rhizoma cibotii and 2 parts of fructus viticis.
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following steps:
grinding madder and combined spicebush root into fine powder to obtain madder powder and combined spicebush root powder for later use;
crushing Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae, and extracting with water to obtain extractive solution;
mixing Mel and the extractive solution, heating and refining to obtain refined Mel;
mixing the refined honey with the madder powder and the combined spicebush root powder to obtain the traditional Chinese medicine composition.
In some embodiments of the present invention, the radix rubiae and radix linderae are further washed and dried before the milling step.
In some embodiments of the present invention, the cleaning is performed by rinsing with flowing water for 2-4 times, and the drying is performed at 30-40 ℃ until the water content is less than 5%.
In some embodiments of the present invention, the particle size of the madder powder and the lindera aggregate powder is 100 to 200 meshes.
In some embodiments of the present invention, the number of the water extractions is 2 to 4, and each water extraction specifically includes: adding clear water with the mass being 8-12 times that of the raw materials, boiling with big fire, then boiling with small fire, and filtering for 1-3 hours to obtain filtrate; mixing the filtrates, and collecting the extractive solution.
In some embodiments of the invention, the mass of the honey is 8-15% of the mass of the extracting solution, the refining temperature is 100-120 ℃, and the water content of the refined honey is 10-20%.
In some embodiments of the invention, the mixing temperature of the refined honey, the madder powder and the combined spicebush root is 40-50 ℃.
The traditional Chinese medicine composition can be prepared into general medical formulations such as tablets, pills, granules, capsules and the like.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 50g of madder, 55g of combined spicebush root, 18g of safflower, 18g of orientvine root, 13g of astragalus, 13g of henbane stem, 10g of alpinia katsumadai, 6g of star anise, 6g of allium macrostemon, 7g of mussel, 6g of storax, 5g of tabasheer, 3g of liquorice, 2g of rhizoma acori graminei, 3g of rhizoma cibotii and 2g of fructus viticis.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 2 times, drying radix Rubiae and radix Linderae in oven at 35 deg.C until water content is lower than 5%, and pulverizing into 150 mesh radix Rubiae powder and radix Linderae powder;
directly crushing the rest raw materials into 10-mesh granules, adding clear water 8 times the mass of the granules, boiling with strong fire, decocting with slow fire for 2h, pouring out the filtrate, repeatedly extracting with water for 2 times, and mixing the filtrates to obtain an extract;
pouring the extracting solution into a pot, adding honey with the mass of 10% of the extracting solution, uniformly mixing, heating to 110 ℃, and refining to obtain refined honey with the water content of 16%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, and making into pill.
Example 2
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 55g of madder, 60g of combined spicebush root, 15g of safflower, 15g of orientvine root, 12g of astragalus, 15g of henbane, 15g of alpinia katsumadai, 8g of star anise, 5g of allium macrostemon, 9g of mussel, 8g of storax, 6g of tabasheer, 2g of liquorice, 2g of rhizoma acori graminei, 3g of rhizoma cibotii and 1g of fructus viticis.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 3 times, drying radix Rubiae and radix Linderae in a 40 deg.C oven until water content is lower than 5%, and pulverizing into 120 mesh radix Rubiae powder and radix Linderae powder;
directly crushing the rest raw materials into 20-mesh granules, adding 10 times of clear water, boiling with strong fire, decocting with slow fire for 3 hr, pouring out filtrate, repeatedly extracting with water for 2 times, and mixing filtrates to obtain extractive solution;
pouring the extracting solution into a pot, adding honey with the mass of 12% of the extracting solution, uniformly mixing, heating to 115 ℃ and refining to obtain refined honey with the water content of 15%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, and making into pill.
Example 3
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 45g of madder, 50g of combined spicebush root, 20g of safflower, 20g of polygonum orientale root, 15g of astragalus membranaceus, 12g of herba aristolochiae, 10g of alpinia katsumadai, 5g of star anise, 8g of allium macrostemon, 6g of mussel, 5g of storax, 5g of tabasheer, 3g of liquorice, 1g of rhizoma acori graminei, 2g of rhizoma cibotii and 1g of fructus viticis.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 3 times, drying radix Rubiae and radix Linderae in an oven at 30 deg.C until water content is lower than 5%, and pulverizing into 200 mesh radix Rubiae powder and radix Linderae powder;
directly crushing the other raw materials into 20-mesh granules, adding clear water with the mass of 12 times, boiling with strong fire, decocting with slow fire for 2h, pouring out the filtrate, repeatedly extracting with water for 2 times, and mixing the filtrates to obtain an extract;
pouring the extracting solution into a pot, adding honey with the mass of 15% of the extracting solution, uniformly mixing, heating to 120 ℃ and refining to obtain refined honey with the water content of 12%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, making into small granule, and making into capsule.
Example 4
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 60g of madder, 40g of combined spicebush root, 15g of safflower, 25g of polygonum orientale root, 18g of astragalus membranaceus, 15g of herba aristolochiae, 8g of alpinia katsumadai, 10g of star anise, 10g of allium macrostemon, 5g of mussel, 5g of storax, 4g of tabasheer, 5g of liquorice, 3g of rhizoma acori graminei, 1g of rhizoma cibotii and 3g of fructus viticis.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba Sonchi Oleracei, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 2 times, drying radix Rubiae and radix Linderae in a 32 deg.C oven until the water content is lower than 5%, and pulverizing into 150 mesh radix Rubiae powder and radix Linderae powder;
directly crushing the other raw materials into 10-mesh granules, adding 11 times of clear water by mass, boiling with strong fire, decocting with slow fire for 2h, pouring out the filtrate, repeatedly extracting with water for 3 times, and mixing the filtrates to obtain an extract;
pouring the extracting solution into a pot, adding honey with the mass of 8% of the extracting solution, uniformly mixing, heating to 120 ℃ and refining to obtain refined honey with the water content of 20%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, making into small granule, and making into capsule.
Example 5
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 38g of madder, 65g of combined spicebush root, 30g of safflower, 15g of polygonum orientale root, 12g of astragalus membranaceus, 10g of herba aristolochiae, 15g of alpinia katsumadai, 5g of star anise, 5g of allium macrostemon, 10g of mussel, 8g of storax, 8g of tabasheer, 2g of liquorice, 1g of rhizoma acori graminei, 3g of rhizoma cibotii and 1g of fructus viticis.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba Sonchi Oleracei, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 2 times, drying radix Rubiae and radix Linderae in oven at 35 deg.C until water content is lower than 5%, and pulverizing into 150 mesh radix Rubiae powder and radix Linderae powder;
crushing the rest raw materials into 10 mesh particles, adding 10 times of clear water, boiling with strong fire, decocting with slow fire for 1 hr, pouring out filtrate, repeatedly extracting with water for 3 times, and mixing filtrates to obtain extractive solution;
pouring the extracting solution into a pot, adding honey with the mass of 10% of the extracting solution, uniformly mixing, and heating to 120 ℃ for refining to obtain refined honey with the water content of 10%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, and making into pill.
Example 6
A preparation method of a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases comprises the following raw materials: 45g of madder, 60g of combined spicebush root, 28g of safflower, 15g of prince feather root, 15g of astragalus root, 10g of henbane stem, 15g of alpinia katsumadai, 5g of star anise, 5g of allium macrostemon, 8g of mussel, 8g of storax, 5g of tabasheer, 2g of liquorice, 1g of grassleaf sweelflag rhizome, 3g of cibot rhizome and 2g of chastetree fruit.
The preparation method comprises the following steps: cleaning radix Rubiae, radix Linderae, Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba Sonchi Oleracei, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae with clear water for 2 times, drying radix Rubiae and radix Linderae in an oven at 30 deg.C until the water content is lower than 5%, and pulverizing into 150 mesh radix Rubiae powder and radix Linderae powder;
crushing the rest raw materials directly into 10 mesh granules, adding 12 times of clear water, boiling with strong fire, decocting with slow fire for 1 hr, pouring out the filtrate, repeatedly extracting with water for 2 times, and mixing the filtrates to obtain extractive solution;
pouring the extracting solution into a pot, adding honey with the mass of 10% of the extracting solution, uniformly mixing, heating to 120 ℃ and refining to obtain refined honey with the water content of 16%;
mixing refined Mel with radix Rubiae powder and radix Linderae powder, and making into pill.
Comparative example 1
The comparative example differs from example 1 in that: in this comparative example, madder and lindera strychnifolia were not added.
Comparative example 2
This comparative example differs from example 1 in that: the dosage of the combined spicebush root is reduced to 15g in the comparative example.
Comparative example 3
This comparative example differs from example 1 in that: in the comparative example, honey is not added, and the extracting solution is directly concentrated and then mixed with the madder powder and the combined spicebush root powder to prepare the pill.
Experimental example 1
200 clean SD rats with the weight of 200 +/-20 g and half of male and female are selected, after the rats are fed adaptively for 10 days, tail vein blood is taken, the blood lipid level is detected, the influence of unhealthy experimental animals on experimental results is eliminated, the rats are randomly divided into 10 groups according to the weight and the sex and then are fed in cages, the groups are respectively 1-10 experimental groups, and 30 rats are fed in each group. Each group of rats was first given 370 ten thousand IU/kg of vitamin D, gavaged within 3 days, and then fed with high-fat diet to create a dyslipidemia animal model.
The administration is started on the 3 rd day after the model building, wherein the experimental groups 1 to 9 respectively adopt the traditional Chinese medicine compositions prepared in the embodiments 1 to 6 and the comparative examples 1 to 3 to perform the gastric lavage and the feeding, each 2 g/day, the experimental group 10 is a blank control group, the rest of the food and the drinking water are the same, and the administration is continuously performed for 30 days. After 30min after the last meal, rats in each group are anesthetized by 3ml/kg of 25% urethane intraperitoneal injection, after 30min, the rats in each group are respectively fixed on the back, the abdominal cavity is cut open, and 5ml of blood is taken from abdominal aorta to serve as a blood fat index. Blood is collected from the abdominal aorta for 5ml, centrifuged at 5000 rpm/min for 10min by a centrifuge, and serum is prepared. AST was detected using aspartate Aminotransferase (AST) activity detection kit (Sigma-Aldrich), and the results are shown in Table 1.
TABLE 1
As can be seen from Table 1, the traditional Chinese medicine compositions prepared in examples 1-6 and comparative examples 1-3 can significantly reduce the AST content compared with the control group, which indicates that the traditional Chinese medicine compositions have treatment effects on vascular diseases. Among them, the effects of embodiments 1 to 6 are particularly preferable.
Similarly, it can be seen from the experimental effects of comparative example 2 and example 1 that even though the same raw materials are used, the effects are greatly different because the dosage of the combined spicebush root is obviously reduced and the compatibility principle is changed.
Experimental example 2
From 10 months to 2020 and 10 months in 2015, 375 patients suffering from cardiovascular and cerebrovascular diseases are treated by adopting the formula of the embodiment 1-6, the specific symptoms are coronary heart disease, angina pectoris, arrhythmia and the like, the age is 30-75 years old, the patients are taken according to the medical advice, and the treatment effect is counted after 1 month in one treatment course and 3 treatment courses.
The evaluation criteria were:
and (3) curing: the discomfort symptoms are completely eliminated;
the method has the following advantages: the discomfort symptoms are relieved or significantly reduced;
and (4) invalidation: the treatment effect is the same as that before treatment;
effective rate (effective case + curative case)/experimental case.
Wherein 241 cases are cured, 128 cases are effective, 6 cases are ineffective, and the total effective rate is 98.4 percent. Among them, the effect is particularly the best in example 1, and the effective rate reaches 100% in five years.
Typical case 1: certain Liangjian, male, 68 years old, has hypertension, cerebral thrombosis, arteriosclerosis for 7 years, palpitation, dizziness, palpitation after fatigue; many Chinese herbal medicine decoctions or pills for treating cardiovascular and cerebrovascular diseases are taken since the disease is treated, but the treatment course is long, the effect is slow, the effect is slight, and great pressure is brought to the psychology of the patient. The traditional Chinese medicine pills of the invention in example 1 are taken three times a day after meals from 2016 for 10 months, 3 pills once; after taking for 10 days, the disease condition is gradually improved, the body feels relaxed, the symptoms of dizziness and headache are relieved, palpitation and fatigue are relieved, after taking for 2 months, adverse symptoms basically disappear, the blood pressure, electrocardiogram and cerebral hemogram are basically normal, and people are advised to pay attention to diet, stop smoking and drinking, and exercise in proper amount; so far, the disease has no recurrence and the mental state is good.
Typical case 2: after a woman in a forest is treated for more than one month, the right side of the whole body is completely paralyzed, and then the right side of the whole body is treated for half a year, the effect is not good in a hospital, after the woman in the forest is taken for 2017, the patient can turn over under the nursing assistance after 10 days after taking the traditional Chinese medicine composition with the formula of the embodiment 2 of the invention, and after the patient continues to take the traditional Chinese medicine composition for 2 months, the patient can get out of the bed to a toilet under the nursing assistance, so that the symptoms are obviously relieved, and after the patient takes the traditional Chinese medicine composition for half a year, the life can be basically self-care.
Typical case 3: some in Yuan, male, 62 years old. The patients with high blood pressure, high blood fat and high blood sugar need to take more than ten kinds of medicines every day in addition to other medical history, and the family worrys about the excessive pressure on internal organs, so the Chinese medicinal composition of the embodiment 5 is adopted for treatment from everywhere according to the introduction of the family. After the medicine is taken for three months, the blood pressure is close to the normal value, the sleep is obviously improved, after the medicine is continuously taken for half a year, the rest medicines are basically stopped, and the people advocate to properly exercise until the body is healthy.
In conclusion, the embodiment of the invention provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. According to the invention, the madder has the effects of removing blood stasis and stimulating the menstrual flow, is cool in nature and can cool blood to clear away the heart fire and calm the nerves, the combined spicebush root has the effects of guiding qi downward and dispelling cold, and simultaneously has the effects of exciting cerebral cortex, promoting respiration, exciting cardiac muscle and vasodilatation, increasing fibrinolysis and reducing plasma viscosity, and the two medicines can remove blood stasis and promote menstruation while dilating blood vessels, and are monarch medicines together; safflower is adopted to improve myocardial ischemia, polygonum orientale root promotes tissue regeneration, promotes new angiogenesis and establishes collateral circulation, astragalus is matched to tonify qi and raise yang, henbane and alpinia katsumadai seed promote qi circulation and remove stagnation, so that whole blood is driven to run and metabolize, and monarch drugs are assisted to play a better effect, and are used as ministerial drugs together; adopts star anise to warm yang, allium macrostemon to dissipate stagnation and mussel to tonify deficiency and consolidate the body, and adopts storax and tabasheer to induce resuscitation and refresh mind to assist the dutchmanspipe stem to sooth the liver and relieve depression as adjuvant drugs; finally, liquorice is used for blending, and the rhizoma acori graminei, the rhizoma cibotii and the fructus viticis are used for guiding the medicines to directly reach the focus of infection, thereby serving as a guiding medicine. The invention has reasonable medicine use and combination of various medicines, and can play a role in treating both symptoms and root causes of cardiovascular and cerebrovascular diseases.
The preparation method provided by the invention has the advantages that the madder and the combined spicebush root are ground into fine powder, other raw materials are extracted by water to form extracting solution, the extracting solution is mixed with honey after refining, and pills or granules are prepared, wherein the effective components are high, the treatment effect can be improved, and the treatment period is shortened.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. A traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases is characterized by comprising the following raw materials in parts by weight: 38-60 parts of madder, 40-65 parts of combined spicebush root, 15-30 parts of safflower, 15-25 parts of orientvine root, 12-18 parts of astragalus membranaceus, 10-15 parts of henbane, 8-15 parts of katsumade galangal seed, 5-10 parts of star anise, 5-10 parts of allium macrostemon, 5-10 parts of mussel, 4-8 parts of storax, 5-8 parts of tabasheer, 2-5 parts of liquorice, 1-3 parts of grassleaf sweelflag rhizome, 1-3 parts of rhizoma cibotii and 1-3 parts of fructus viticis.
2. The traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 45-55 parts of madder, 50-60 parts of combined spicebush root, 15-20 parts of safflower, 15-20 parts of polygonum orientale root, 12-15 parts of astragalus membranaceus, 12-15 parts of henbane, 10-15 parts of katsumade galangal seed, 5-8 parts of star anise, 5-8 parts of allium macrostemon, 6-9 parts of mussel, 5-8 parts of storax, 5-6 parts of tabasheer, 2-3 parts of liquorice, 1-2 parts of grassleaf sweelflag rhizome, 2-3 parts of rhizoma cibotii and 1-2 parts of fructus viticis.
3. The traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 50 parts of madder, 55 parts of combined spicebush root, 18 parts of safflower, 18 parts of orientvine root, 13 parts of astragalus, 13 parts of Japanese tussah vine, 10 parts of alpinia katsumadai, 6 parts of star anise, 6 parts of allium macrostemon, 7 parts of mussel, 6 parts of storax, concretio silicea bambusae, 5 parts of concretio silicea bambusae, 3 parts of liquorice, 2 parts of rhizoma acori graminei, 3 parts of rhizoma cibotii and 2 parts of fructus viticis.
4. A method for preparing the Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases according to any one of claims 1 to 3, comprising the following steps:
grinding madder and combined spicebush root into fine powder to obtain madder powder and combined spicebush root powder for later use;
crushing Carthami flos, radix Polygoni orientalis, radix astragali, caulis Aristolochiae, semen Alpiniae Katsumadai, fructus Anisi Stellati, Bulbus Allii Macrostemi, herba mussel, storax, concretio silicea Bambusae seu Schizostachyi, Glycyrrhrizae radix, rhizoma Acori Graminei, rhizoma Cibotii and fructus Vitics Simplicifoliae, and extracting with water to obtain extractive solution;
mixing Mel and the extractive solution, heating and refining to obtain refined Mel;
mixing refined honey, madder powder and combined spicebush root powder to obtain the traditional Chinese medicine composition.
5. The method for preparing the Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases according to claim 4, wherein the radix rubiae and radix linderae are further cleaned and dried before the milling step.
6. The method for preparing a Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases according to claim 5, wherein the washing is performed by rinsing with running water for 2-4 times, and the drying is performed at 30-40 ℃ until the water content is less than 5%.
7. The preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 4, wherein the particle size of the madder powder and the lindera aggregate powder is 100-200 meshes.
8. The preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 4, wherein the number of water extractions is 2-4, and each water extraction specifically comprises: adding clear water with the mass being 8-12 times that of the raw materials, boiling with big fire, then decocting with small fire, and filtering after 1-3 hours to obtain filtrate; the filtrates obtained by multiple water extractions are combined to obtain the extracting solution.
9. The preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 4, wherein the mass of the honey is 8-15% of the mass of the extracting solution, the refining temperature is 100-120 ℃, and the water content of the refined honey is 10-20%.
10. The preparation method of the traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases according to claim 9, wherein the mixing temperature of the refined honey, the madder powder and the combined spicebush root is 40-50 ℃.
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| 王新虎: "蒋德隆益气活血法治疗内科病学术经验", 《亚太传统医药》 * |
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