CN106110291A - A kind of nutritional preparation for kidney cell reparation and preparation method thereof - Google Patents
A kind of nutritional preparation for kidney cell reparation and preparation method thereof Download PDFInfo
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- CN106110291A CN106110291A CN201610498161.7A CN201610498161A CN106110291A CN 106110291 A CN106110291 A CN 106110291A CN 201610498161 A CN201610498161 A CN 201610498161A CN 106110291 A CN106110291 A CN 106110291A
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- extract
- rhizoma polygonati
- concha ostreae
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- radix ginseng
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention belongs to a kind of nutritional preparation and preparation method thereof, a kind of nutritional preparation for kidney cell reparation and preparation method thereof, it is characterized in that, the innate efficacy such as Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into；Based on its parts by weight, wherein Rhizoma Polygonati extract 1 20 parts, Radix Ginseng extract 1 10 parts, Fructus Rubi extract 1 20 parts, Concha Ostreae extract 1 30 parts, Maca extract 1 10 parts, 1 30 parts of fine peptide powder, soybean peptide 1 30 parts, plant sterol 1 10 parts；Adjuvant on one or more pharmaceuticss is added on the basis of above-mentioned composition.The present invention be applicable to kidney cell repair nutritional preparation first by functional component scientific combination such as Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterols, reasonably combined.
Description
Technical field
The invention belongs to a kind of nutritional preparation and preparation method thereof, a kind of nutrition system repaired for kidney cell
Agent and preparation method thereof.
Background technology
Kidney belongs to a part for urinary system, and in Chinese medicine, kidney belongs to one of the five internal organs.Kidney be congenital it
This, be human life congenital at all, be related to the mankind existence procreation.Kidney qi profit and loss are except reaction kidney and relevant group thereof
Whether knit health, also represent vitality be prosperous be weak.Disease of suffering from a deficiency of the kidney performance so-called is suffered from a deficiency of the kidney, deficiency of the kidney, cover kidney and kidney
The qi-blood circulating of warp, or the organ-tissue that function associates with kidney generation, such as problems such as relevant urinary system, reproductive system.
Finger renal function of suffering from a deficiency of the kidney weakens, and needs according to different symptom medical treatments.The deficiency in both YIN and YANG of kidney, kidney qi metaplasia is not enough,
Disease sees spermatorrhea, premature ejaculation, and after urine, the sound of rain pattering is not to the utmost, and total urination time is many and clear, soreness of the waist and knees, and auditory dysesthesia is breathed hard, and extremity are the warmest, arteries and veins
Thin and delicate etc..
The kind suffered from a deficiency of the kidney has a lot, and most common of which is deficiency of the kidney yin, insufficiency of kidney-YANG.The symptom suffered from a deficiency of the kidney: the symptom of insufficiency of kidney-YANG
For the soreness of waist, cold extremities, fear of cold, the most also edema, for the symptom of " trembling with fear ", sexual function is bad also results in insufficiency of kidney-YANG；Kidney yin
Empty symptom is " hot ", mainly has the soreness of waist, scorching, night sweat, sweating due to debility, dizziness, tinnitus etc..Modern science proves, when people occurs kidney
Time empty, no matter deficiency of the kidney yin or insufficiency of kidney-YANG, all can cause the reduction of the immunocompetence of people, have more evidence to show, suffer from a deficiency of the kidney and send out
Time raw, the immunocompetence of kidney reduces, and the microcirculqtory system of kidney also can be blocked, and kidney network presents obstructed.
As the patent documentation of publication number CN104689010A (application number CN201510127003.6) discloses a kind for the treatment of
The Chinese medicine preparation suffered from a deficiency of the kidney, this Chinese medicine preparation is made up of the raw material of following weight portion: Radix Rehmanniae Preparata 12-28 part, Fructus Corni 16-28
Part, Rhizoma Dioscoreae 11-25 part, Cortex Eucommiae 9-21 part, Radix Achyranthis Bidentatae 10-22 part, Poria 8-20 part, Semen Persicae 7-17 part, Fructus Aurantii Immaturus 7-15 part, Fructus Chebulae 9-
21 parts, Cornu Cervi Pantotrichum 10-22 part, Rhizoma Corydalis 13-27 part, Radix Paeoniae Rubra 7-15 part, Pericarpium Citri Reticulatae 8-18 part, Sargassum 7-17 part, Rhizoma Alismatis 9-21 part, Mulberry
Egg capsule of a mantis 8-20 part, Semen Cuscutae 20-36 part, Radix Astragali 8-18 part, Lignum Aquilariae Resinatum 5-9 part.Publication number CN105233090A (application number
CN201510827452.1) patent documentation discloses the Chinese medicine that a kind for the treatment of is suffered from a deficiency of the kidney, and this Chinese medicine is by following weight portion
Raw material is made: broken benefit 8-15 gram, Millettia Speciosa 18-22 gram, Semen Coicis 17-23 gram, Radix Achyranthis 18-23 gram, Rhizoma Atractylodis 16-25 gram, the Radix Aucklandiae
7-12 gram, Rhizoma Cibotii 12-18 gram, Radix Flemingiae Philippinensis 13-17 gram, Cortex Eucommiae 12-20 gram.
Prior art still has several drawbacks, the Chinese medicine that current clinical treatment is suffered from a deficiency of the kidney has, but specific aim is not
By force, effect is unsatisfactory, and edible inconvenience, and formula and technique all await improving further and improving.
Summary of the invention
For the deficiencies in the prior art, it is an object of the invention to provide one and prepare simply, conveniently take, safely and effectively
For nutritional preparation that kidney cell is repaired and preparation method thereof.
The technical problem to be solved is to provide a kind of nutritional preparation repaired for kidney cell, its feature
It is, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, Semen sojae atricolor
The innate efficacy such as peptide, plant sterol becomes to be grouped into, the part of Rhizoma Polygonati extract 1-20 based on its parts by weight, Radix Ginseng extract 1-10
Part, Fructus Rubi extract 1-20 part, Concha Ostreae extract 1-30 part, Maca extract 1-10 part, fine peptide powder 1-30 part, soybean peptide 1-
30 parts, plant sterol 1-10 part；Adjuvant on one or more pharmaceuticss is added, as Fructus Hordei Germinatus is stuck with paste on the basis of above-mentioned composition
Essence, starch, microcrystalline Cellulose, sodium carboxymethyl cellulose, xanthan gum, guar gum, sucrose fatty acid ester, magnesium stearate, oligomeric
Fructose, oligomeric xylose, oligomeric isomaltose, mannitol, isomaltulose, hydroxyl isomaltulose, silicon dioxide, aspartame,
The various dosage forms that sucralose, edible essence etc. are mixed, such as, can be made into granule, powder, tablet, capsule, microgranule
Agent, slow releasing tablet.
Preferred dosage form is tablet and capsule.
The preparation method of a kind of nutritional preparation repaired for kidney cell, it is characterised in that the method includes walking as follows
Rapid:
Step one: weigh Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp by prescription amount
Extract, fine peptide powder, soybean peptide, plant sterol are raw material；
Step 2: by said components, adds adjuvant, mix homogeneously；
Step 3: make nutritional preparation；
Described Rhizoma Polygonati extract is obtained by following method:
(1) pre-treatment: picked by Rhizoma Polygonati, chopping is thrown and is soaked 1-3h to extraction pot；
(2) extract: add 3-5 times amount pure water, reflux, extract, 3-4h for the first time, from solvent boiling timing, control temperature 100
DEG C, insulation then, extrudes medicinal liquid, and second time adds 3-5 times amount pure water reflux, extract, 2-3h；Third time adds 2-4 times amount
Pure water reflux, extract, 1-2h；
(3) concentrate: will carry out concentrating under reduced pressure in the medicinal liquid suction concentration tank of extraction, temperature controls below 70 DEG C, vacuum
Degree controls at more than 0.06Mpa, and extractum is pressed into fluid reservoir cooling；
(4) precipitate with ethanol, standing: the stirring of 95% ethanol injecting 3-5 times amount stands 2-3h；
(5) filter: the upper pure liquid after standing separates, and filters out alcohol liquid and obtains dilute extractum, concentrates；
(6) secondary precipitate with ethanol: being dissolved by thick paste 80% ethanol of 3-4 times amount, incline supernatant；
(7) concentrate: the medicinal liquid after filtering concentrates, dense one-tenth thick paste；
(8) it is spray-dried: thick paste is sprayed, moisture ＜ 5%.
Described Concha Ostreae extract is obtained by following method:
(1) extracting: cleaned by fresh Concha Ostreae, add 3-5 times amount pure water, boil 30-60min, filtration under diminished pressure, pressure is
98kpa；Collecting filtrate, residue adds 3-5 times amount pure water, boils 30-60min, filtration under diminished pressure, pressure is 98kpa；Collect and close
And filtrate；
(2) concentrate: filter vacuum is distilled, wherein pressure 0.133-0.66kpa, temperature 70-80 DEG C；Distillate is added 1-
2 times amount pure water, then distill, wherein pressure 0.133-0.66kpa, temperature 70-80 DEG C；
(3) it is spray-dried: being spray-dried by distillate, outlet temperature is 80-85 DEG C, and speed of dripping is per minute
30ml。
Described fine peptide powder is obtained by following method:
(1) by beef cattle Testis Et penis Bovis seu Bubali rub, according to meat water ratio 1:3-5 ratio add distilled water, hydrolysis temperature 40-60 DEG C,
Regulation pH value is 9-11；
(2) add the alkaline protease of 0.05%-0.5% (mass ratio), be placed in constant temperature stirring enzymolysis in water-bath, during enzymolysis
Between 2-5h；
(3) heating enzyme denaturing, 85-100 DEG C, 20-30min；
(4) cross the slagging-off of 20-40 eye mesh screen, remove the oil reservoir on upper strata.Then by enzymolysis solution at 2000-6000r/min,
It is centrifuged under the conditions of 10min, takes supernatant；
(5) directly heat concentration, to solid content about 12.5%, after having concentrated, enzymolysis solution is sprayed
Being dried, injector temperature is 160 DEG C, and outlet temperature is 85 DEG C, and vaporizing capacity is 1.0L/h (in terms of H2O), prepares dry essence
Gly-His-Lys, measures its activity.
Composition principle for the nutritional preparation of kidney cell reparation of the present invention is:
Fine peptide powder derives from Testis Et penis Bovis seu Bubali, and Testis Et penis Bovis seu Bubali makes again cattle rush, and is the external genitalia of bull, ox.Compendium of Material Medica is recorded: Testis Et penis Bovis seu Bubali master
Control man's sexual impotence, premature ejaculation, kidney invigorating and YANG supporting, vital base and primordial QI consolidating.Testis Et penis Bovis seu Bubali is rich in compositions such as androgen, protein, fat.Testis Et penis Bovis seu Bubali is through special
Technique extracts protein and further enzymolysis becomes small-molecular peptides, beneficially absorption of human body, effectively provides the spy that kidney reparation needs
Different protein raw materials.
Rhizoma Polygonati is the dry rhizome of liliaceous plant Rhizoma Polygonati.Sweet in the mouth, property is put down.Strengthening bone and muscle, benefit marrow, mend vital essence.Rhizoma Polygonati is
Traditional health preserving good merchantable brand.In Rhizoma Polygonati, polysaccharide component is most important functional nutrient material, is the main matter basis mending vital essence.
Moreover modern nutriology research shows: Rhizoma Polygonati, can be by the useful micro-life in intestinal possibly together with higher functional oligose
Thing bacillus bifidus utilizes, and promotes bacillus bifidus propagation, improves the microecological environment of intestinal, promote the synthesis of vitamin B group and calcium,
The absorption of the mineral such as magnesium, ferrum, improves immunity of organisms and premunition, can decompose enterogenous endotoxin and carcinogen, prevent various
Chronic disease and cancer, reduce cholesterol in serum and blood lipid level.Biologically active peptide is also the important nutritional labeling in Rhizoma Polygonati, closely
Research over Nian shows, has more more preferable absorbent properties than aminoacid with the low peptide that several aminoacid are combined into, and many
Peptide has crude protein or its composition unexistent physiological function of aminoacid, as promoted calcium absorption, blood pressure lowering, cholesterol reducing, calmness
Nerve, immunomodulating, antioxidation, removing free radical, the function such as anticancer.
Concha Ostreae belongs to Ostreidae or Yan Ha section, bivalve, is distributed in each ocean in temperate zone and the torrid zone stretch of coastal water.
Salty, it is slightly cold.Return liver, gallbladder, kidney channel.Suppressing the hyperactive liver and subsiding YANG；Tranquillization with heavy prescription；Hard masses softening and resolving；Restrain astringent or styptic treatment for spontaneous sweating.Concha Ostreae is a kind of high protein, low
Fat, easily digestion and nutritious food, Oysters is contained within manufacturing the indispensable arginine of sperm institute in a large number with micro-
Secondary element zinc.Arginine is the main component manufacturing sperm, and zinc promotes hormonal secretion.Edible oyster can raising property merit
Energy.Sexual disorder, sexual impotence, prostatauxe, the congruent andropathy of sexual organ development, be because zinc
Not enough and cause.The aminoacid contained in Concha Ostreae can improve the function of liver, the savings of suppression lactic acid, helps to accelerate fatigue
Recover with muscle power enhancement.It addition, the taurine in Concha Ostreae is possible not only to help recovery tired on health same with liver glycogen
Time be also highly effective to recovery tired mentally.
Fructus Rubi is the dry fruit of rosaceous plant rubus chingii Hu Rubus chingii Hu.Nature and flavor: sweet in the mouth, acid,
Warm in nature.Fructus Rubi returns liver, kidney, bladder warp.There is supplementing the kidney to control the nocturnal reducing urination, effect of nourishing the liver to improve visual acuity.It is usually used in emission and spermatorrhea, the enuresis
Frequent micturition, impotence and premature ejaculation, mesh is the most dim-sighted.
Beneficial effects of the present invention:
1, the present invention be applicable to the nutritional preparation of kidney cell reparation first by Rhizoma Polygonati extract, Radix Ginseng extract, cover basin
The functional component scientific combination such as seed extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol, rationally
Collocation.
2, Rhizoma Polygonati extract and the Concha Ostreae extract processing technique of the present invention are simple, it is easy to operation, and active component enriches.
3, clinical and experimental study proves, nutritional preparation effect of the present invention is notable.
4, this prescription raw material derives from food, safe and free of toxic and side effects.
Detailed description of the invention
The present invention is further illustrated below:
Embodiment 1
A kind of for kidney cell repair nutritional preparation, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract,
The innate efficacy such as Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into, and wherein, Rhizoma Polygonati extracts
Thing 1kg, Radix Ginseng extract 2kg, Fructus Rubi extract 4kg, Concha Ostreae extract 3kg, Maca extract 2kg, fine peptide powder 3kg part,
Soybean peptide 10kg, plant sterol 5kg.
The preparation method of the above-mentioned nutritional preparation repaired for kidney cell, concretely comprises the following steps:
(1) Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction are weighed by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adjuvant sodium carboxymethyl cellulose 0.1kg, sucralose 0.01kg, mix homogeneously are added；
(3) mixed powder is made powder.
Embodiment 2
A kind of for kidney cell repair nutritional preparation, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract,
The innate efficacy such as Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into, and wherein, Rhizoma Polygonati extracts
Thing 10kg, Radix Ginseng extract 6kg, Fructus Rubi extract 11kg, Concha Ostreae extract 16kg, Maca extract 7kg, fine peptide powder
14kg, soybean peptide 15kg, plant sterol 6kg.
The preparation method of the above-mentioned nutritional preparation repaired for kidney cell, concretely comprises the following steps:
(1) Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction are weighed by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) microcrystalline cellulose excipients 0.5kg, magnesium stearate 0.05kg, silicon dioxide 2kg, mix homogeneously are added；
(3) mixed powder is made tablet.
Embodiment 3
A kind of for kidney cell repair nutritional preparation, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract,
The innate efficacy such as Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into, and wherein, Rhizoma Polygonati extracts
Thing 18kg, Radix Ginseng extract 9kg, Fructus Rubi extract 19kg, Concha Ostreae extract 29kg, Maca extract 9kg, fine peptide powder
30kg, soybean peptide 29kg, plant sterol 10kg.
The preparation method of the above-mentioned nutritional preparation repaired for kidney cell, concretely comprises the following steps:
(1) Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction are weighed by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adjuvant maltodextrin 10kg, starch 8kg, mix homogeneously are added；
(3) mixed powder is made capsule.
Embodiment 4
A kind of for kidney cell repair nutritional preparation, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract,
The innate efficacy such as Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into, and wherein, Rhizoma Polygonati extracts
Thing 6kg, Radix Ginseng extract 3kg part, Fructus Rubi extract 5kg, Concha Ostreae extract 10kg, Maca extract 6kg, fine peptide powder
10kg, soybean peptide 8kg, plant sterol 4kg.
The preparation method of the above-mentioned nutritional preparation repaired for kidney cell, concretely comprises the following steps:
(1) Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction are weighed by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adjuvant xanthan gum 0.8kg, edible essence 0.5kg, mix homogeneously are added；
(3) mixed powder is made granule.
Embodiment 5
A kind of for kidney cell repair nutritional preparation, by Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract,
The innate efficacy such as Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into, and wherein, Rhizoma Polygonati extracts
Thing 15kg, Radix Ginseng extract 7kg, Fructus Rubi extract 16kg, Concha Ostreae extract 22kg, Maca extract 7kg, fine peptide powder
26kg, soybean peptide 25kg, plant sterol 6kg.
The preparation method of the above-mentioned nutritional preparation repaired for kidney cell, concretely comprises the following steps:
(1) Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction are weighed by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adding mannitol 2kg, sucrose fatty acid ester 0.1kg, guar gum 0.1kg, microcrystalline Cellulose 6kg, mixing is all
Even；
(3) mixed powder is made microgranule.
Radix Ginseng extract in above-described embodiment 1-5, Fructus Rubi extract, Maca extract, soybean peptide, plant sterol and auxiliary
Material is commercially available prod.
Described in above-described embodiment 1-5, Rhizoma Polygonati extract is obtained by following method:
(1) pre-treatment: picked by Rhizoma Polygonati, chopping is thrown and is soaked 2h to extraction pot.
(2) extract: add 4 times amount pure water, for the first time reflux, extract, 4h, from solvent boiling timing, control temperature 100 DEG C,
Insulation is then.Extruding medicinal liquid, second time adds 4 times amount pure water reflux, extract, 3h.Third time adds 3 times amount pure water backflows and carries
Take 2h.
(3) concentrate: will carry out concentrating under reduced pressure in the medicinal liquid suction concentration tank of extraction, temperature controls below 70 DEG C, vacuum
Degree controls at more than 0.06Mpa, and extractum is pressed into fluid reservoir cooling.
(4) precipitate with ethanol, standing: the stirring of 95% ethanol injecting 4 times amount stands 3h.
(5) filter: the upper pure liquid after standing separates, and filters out alcohol liquid and obtains dilute extractum, concentrates.
(6) secondary precipitate with ethanol: being dissolved by thick paste 80% ethanol of 4 times amount, incline supernatant.
(7) concentrate: the medicinal liquid after filtering concentrates, dense one-tenth thick paste.
(8) it is spray-dried: thick paste is sprayed, moisture ＜ 5%.
Described in above-described embodiment 1-5, Concha Ostreae extract is obtained by following method:
(1) extract: being cleaned by fresh Concha Ostreae, add 4 times amount pure water, boil 40min, filtration under diminished pressure, pressure is 98kpa.
Collecting filtrate, residue adds 4 times amount pure water, boils 50min, filtration under diminished pressure, pressure is 98kpa.Collect and merging filtrate.
(2) concentrate: filter vacuum is distilled, wherein pressure 0.66kpa, temperature 75 DEG C.Distillate is added 2 times amount pure water,
Distill again, wherein pressure 0.66kpa, temperature 75 DEG C.
(3) it is spray-dried: being spray-dried by distillate, outlet temperature is 85 DEG C, and speed of dripping is 30ml per minute.
Described in above-described embodiment 1-5, fine peptide powder is prepared by following method:
(1) beef cattle Testis Et penis Bovis seu Bubali is rubbed, add distilled water, hydrolysis temperature 50 DEG C according to the ratio of meat water ratio 1:4, regulate pH
Value is 10；
(2) add the alkaline protease of 0.1% (mass ratio), be placed in constant temperature stirring enzymolysis, enzymolysis time 2h in water-bath；
(3) heating enzyme denaturing, 90 DEG C, 30min；
(4) cross 40 eye mesh screen slagging-off, remove the oil reservoir on upper strata.Then by enzymolysis solution under the conditions of 4000r/min, 10min
Centrifugal, take supernatant；
(5) directly heat concentration, to solid content about 12.5%, after having concentrated, enzymolysis solution is sprayed
Being dried, injector temperature is 160 DEG C, and outlet temperature is 85 DEG C, and vaporizing capacity is 1.0L/h (in terms of H2O).Prepare dry essence
Gly-His-Lys, measures its activity.
The described each amounts of components of one of embodiment 1-5 is increased or decreased according to same ratio, the weight portion of each component of gained
Number relation belongs to protection scope of the present invention, and this is used for all right root in each component of the nutritional preparation that kidney cell is repaired
Include adjuvant and the additive of reasonable volume scope according to techniques well known general knowledge, add on one or more pharmaceuticss
Adjuvant, as maltodextrin, starch, microcrystalline Cellulose, sodium carboxymethyl cellulose, xanthan gum, guar gum, sucrose fatty acid ester,
Magnesium stearate, oligofructose, oligomeric xylose, oligomeric isomaltose, mannitol, isomaltulose, hydroxyl isomaltulose, titanium dioxide
The various dosage forms that silicon, aspartame, sucralose, edible essence etc. are mixed, such as, can be made into granule, powder, sheet
Agent, capsule, microgranule, slow releasing tablet.
The technique effect checking that the present invention produces:
Nutritional preparation of the present invention is carried out clinical research:
1 research method
This research employing district group is random, parallel study, will accord with in Tianjin Nankai Hospital outpatient clinic during winter in 2015
The 50 example nephrasthenia syndrome patients closing inclusive criteria and exclusion standard all take the product of 3 months this nutritional preparation embodiments 2.Respectively at
After 1 month (i.e. one course for the treatment of just terminates), by outpatient service further consultation or call-on back by phone (from the beginning of taking this product) after 3 months
(patient for not having outpatient service further consultation) observes the main clinic symptoms of this 50 example patient, and respectively with take this nutritional preparation before
Do corresponding clinical symptoms comparative analysis.
1.1 pairs of illumination are arranged
The method of own control before and after employing
1.2 diagnostic criteria
1.2.1 case diagnosis inclusion criteria
The Chinese and Western that combination of Chinese and Western medicine deficiency syndrome in the diagnosis basis whole nation are formulated in Henan in 1986 with senile disease Professional Committee
Doctor's deficiency syndrome diagnostic criteria diagnoses: 1. soreness of the waist and knees (non-traumatic)；2. soreness of the shank knee joint is soft or talalgia；3. tinnitus or ear
Deaf；4. loss of hairs or luxated tooth；5. there are the heeltap or incontinence after urine；6. sexual hypofunction or infertile, sterile.More than possess three
Diagnosis.
1.2.2 TCM syndrome diagnostic criteria
" the new Chinese medicine guideline of clinical investigations " published according to China Medical Science Press in 2002 to and 2007
The criterion of " Diagnostics of Chinese Medicine related content " nephrasthenia syndrome that April in year, China Traditional Chinese Medicine Publishing House published: primary symptom: waist knee joint acid
Soft, fatigue and weakness, hyposexuality, breathe hard；Secondary disease: nocturia, pale complexion, edema of lower limbs, tooth pine loss of hairs, dribble of urine is not
To the greatest extent, urinary incontinence, spermatorrhea, premature ejaculation, leukorrhagia is the dilutest, pale tongue, and tongue is white, and retarded pulse is not enough.Possess at least 2 primary symptom (soreness of the waist and knees
Indispensable), secondary disease at least 2 diagnosable for syndrome of deficiency of kidney-QI.
It should be noted that in the Diagnostics of Chinese Medicine teaching material of various versions, do not have simple deficiency of kidney-QI pattern of syndrome, although clinical
On the most common situation to deficiency of kidney-QI.In this is studied, carry out statistical calculating for convenience to improve this nutrition system
The accuracy rate of agent clinical observation on the therapeutic effect, combines according to the clinical symptoms of the 50 example patients collected and the content of Diagnostics of Chinese Medicine
" new Chinese medicine guideline of clinical investigations " is provided with the diagnostic criteria of syndrome of deficiency of kidney-QI.
1.3 inclusive criteria
(1) patient meets above-mentioned diagnostic criteria
(2) age 18-60 one full year of life
(3) serious disease person is got rid of on inspection
Have to comply with all of the above.
1.4 exclusion standard
(1) age crowd below 18 one full year of life or more than 60 one full year of life.
(2) patient of major disease it has been diagnosed as.
(3) gestation or women breast-feeding their children.
(4) to Chinese medicine allergy sufferers.
(5) there are the severe primary diseases such as cardiovascular and cerebrovascular vessel, liver, hemopoietic system, or affect its serious disease survived, as
Tumor or acquired immune deficiency syndrome (AIDS).
(6) making a thorough investigation of judgement, have and reduce into group probability or make other pathological changes complicated into group, working environment often becomes
Dynamic etc. easily cause situation lost to follow-up.
(7) patient of other drug clinical research is being participated in.
Occur 1 i.e. to get rid of.
1.5 observation index
(1) the clinical disease integration after disease integration situation before each patient treatment, treatment 1 month and after treatment 3 months
Situation of change.
(2) tcm symptom sign quantization modulation standard with reference to " new Chinese medicine clinical guidance principle " and sets score value.
Symptom of suffering from a deficiency of the kidney integrated reference:
1.6 Therapeutic Method
Take the present invention for the nutritional preparation (embodiment 2) that kidney cell is repaired, each 4, every day twice, 1 month
One course for the treatment of.
1.7 efficacy assessment standard
Tcm syndrome efficacy assessment standard: with reference to " new Chinese medicine clinical guidance principle "
Nimodipine method: therapeutic index N=[(integration after integration one is treated before treating)/treat front integration] × 100%
Clinical recovery: clinical symptoms, sign disappear or substantially disappear, disease integration reduces >=95%
Effective: clinical symptoms, sign are obviously improved, disease integration reduces >=70%
Effective: clinical symptoms, sign all take a favorable turn, disease integration reduces >=30%
Invalid: clinical symptoms, sign are not improved, and even increase the weight of, disease integration reduces less than 30%
3 statistical analysiss
SPSS19.0 statistical analysis software is used to calculate.Observation index for nutritional preparation curative effect of the present invention uses non-ginseng
Number inspection, other relevant items all use descriptive statistical analysis.Enumeration data employing X 2 test, measurement data mean,
Patients before and after intervention compares employing paired-sample t test.
4 interpretations of result
Table 1 suffer from a deficiency of the kidney before treatment with treat TCM symptom score after 1 month and compare
Table 2 suffer from a deficiency of the kidney before treatment with treat TCM symptom score after 3 months and compare
As shown in table 1, suffer from a deficiency of the kidney group treatment 1 month after soreness of the waist and knees, fatigue and weakness, breathe hard, nocturia, pale complexion,
Edema of lower limbs, hyposexuality improve significantly (p ＜ 0.05) before the most relatively treating.
As shown in table 2, suffer from a deficiency of the kidney group treatment 1 month after soreness of the waist and knees, fatigue and weakness, breathe hard, nocturia, pale complexion,
Edema of lower limbs, tooth pine loss of hairs, hyposexuality improve significantly (p ＜ 0.05) before the most relatively treating.
Table 3 suffer from a deficiency of the kidney treatment 1 month and 3 months after tcm symptom comparitive study
As table 3 shows, 50 examples of suffering from a deficiency of the kidney, clinical recovery 7 example (14%) after treating 1 month, effective 20 examples (40%), effective 19 examples
(38%), invalid 4 examples (8%), total effective rate 92%；Clinical recovery 10 example (20%) after treating 3 months, effective 21 examples
(42%), effective 17 examples (34%), invalid 2 examples (4%), total effective rate 96%.Suffer from a deficiency of the kidney and treat 1 month and total effective after 3 months
Rate no significant difference (p ＞ 0.05), no difference of science of statistics.
It should be appreciated that embodiment discussed herein and example simply to illustrate that, to those skilled in the art
For, can be improved or converted, and all these modifications and variations all should be belonged to the protection of claims of the present invention
Scope.
Claims (10)
1. the nutritional preparation repaired for kidney cell, it is characterised in that by Rhizoma Polygonati extract, Radix Ginseng extract, cover basin
The innate efficacy such as seed extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol become to be grouped into；By it
Parts by weight meter, wherein Rhizoma Polygonati extract 1-20 part, Radix Ginseng extract 1-10 part, Fructus Rubi extract 1-20 part, Concha Ostreae are extracted
Thing 1-30 part, Maca extract 1-10 part, fine peptide powder 1-30 part, soybean peptide 1-30 part, plant sterol 1-10 part；At above-mentioned composition
On the basis of add adjuvant on one or more pharmaceuticss, such as maltodextrin, starch, microcrystalline Cellulose, carboxymethyl cellulose
Sodium, xanthan gum, guar gum, sucrose fatty acid ester, magnesium stearate, oligofructose, oligomeric xylose, oligomeric isomaltose, manna
It is each that alcohol, isomaltulose, hydroxyl isomaltulose, silicon dioxide, aspartame, sucralose, edible essence etc. are mixed
Plant dosage form.
An a kind of nutritional preparation repaired for kidney cell, it is characterised in that said preparation is made
Granule, powder, tablet, capsule, microgranule or slow releasing tablet.
A kind of nutritional preparation repaired for kidney cell, it is characterised in that said preparation is preferentially made
Piece agent or capsule.
The preparation method of a kind of nutritional preparation repaired for kidney cell, it is characterised in that should
Method comprises the steps:
Step one: weigh Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Lepidinm meyenii Walp extraction by prescription amount
Thing, fine peptide powder, soybean peptide, plant sterol are raw material；
Step 2: by said components, adds adjuvant, mix homogeneously；
Step 3: make nutritional preparation；
Described Rhizoma Polygonati extract is obtained by following method:
(1) pre-treatment: picked by Rhizoma Polygonati, chopping is thrown and is soaked 1-3h to extraction pot；
(2) extract: add 3-5 times amount pure water, reflux, extract, 3-4h for the first time, from solvent boiling timing, control temperature 100 DEG C,
Insulation then, extrudes medicinal liquid；Second time adds 3-5 times amount pure water reflux, extract, 2-3h；Third time adds 2-4 times amount pure water
Reflux, extract, 1-2h；
(3) concentrate: will carry out concentrating under reduced pressure in the medicinal liquid suction concentration tank of extraction, temperature controls below 70 DEG C, vacuum control
Extractum, at more than 0.06Mpa, is pressed into fluid reservoir cooling by system；
(4) precipitate with ethanol, standing: the stirring of 95% ethanol injecting 3-5 times amount stands 2-3h；
(5) filter: the upper pure liquid after standing separates, and filters out alcohol liquid and obtains dilute extractum, concentrates；
(6) secondary precipitate with ethanol: being dissolved by thick paste 80% ethanol of 3-4 times amount, incline supernatant；
(7) concentrate: the medicinal liquid after filtering concentrates, dense one-tenth thick paste；
(8) it is spray-dried: thick paste is sprayed, moisture ＜ 5%；
Described Concha Ostreae extract is obtained by following method:
(1) extracting: cleaned by fresh Concha Ostreae, add 3-5 times amount pure water, boil 30-60min, filtration under diminished pressure, pressure is 98kpa；
Collecting filtrate, residue adds 3-5 times amount pure water, boils 30-60min, filtration under diminished pressure, pressure is 98kpa；Collect and merge filter
Liquid；
(2) concentrate: filter vacuum is distilled, wherein pressure 0.133-0.66kpa, temperature 70-80 DEG C；Distillate is added 1-2 times
Amount pure water, then distill, wherein pressure 0.133-0.66kpa, temperature 70-80 DEG C；
(3) it is spray-dried: being spray-dried by distillate, outlet temperature is 80-85 DEG C, and speed of dripping is 30ml per minute；
Described fine peptide powder is obtained by following method:
(1) beef cattle Testis Et penis Bovis seu Bubali is rubbed, add distilled water, hydrolysis temperature 40-60 DEG C, regulation according to the ratio of meat water ratio 1:3-5
PH value is 9-11；
(2) add the alkaline protease of 0.05%-0.5% (mass ratio), be placed in constant temperature stirring enzymolysis, enzymolysis time 2-in water-bath
5h；
(3) heating enzyme denaturing, 85-100 DEG C, 20-30min；
(4) cross the slagging-off of 20-40 eye mesh screen, remove the oil reservoir on upper strata.Then by enzymolysis solution at 2000-6000r/min, 10min bar
It is centrifuged under part, takes supernatant；
(5) directly heat concentration, to solid content about 12.5%, after having concentrated, enzymolysis solution be spray-dried,
Injector temperature is 160 DEG C, and outlet temperature is 85 DEG C, and vaporizing capacity is that 1.0L/h is (with H2O counts), prepare dry fine peptide powder,
Measure its activity.
A kind of nutritional preparation repaired for kidney cell, it is characterised in that extracted by Rhizoma Polygonati
Thing, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol etc. are natural
Functional component forms；Based on its parts by weight, wherein Rhizoma Polygonati extract 1kg, Radix Ginseng extract 2kg, Fructus Rubi extract 4kg,
Concha Ostreae extract 3kg, Maca extract 2kg, fine peptide powder 3kg part, soybean peptide 10kg, plant sterol 5kg.
The preparation method of a kind of nutritional preparation repaired for kidney cell, it is characterised in that should
Method comprises the steps:
(1) by prescription amount weigh Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract,
Fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adjuvant sodium carboxymethyl cellulose 0.1kg, sucralose 0.01kg, mix homogeneously are added；Mixed powder is made powder.
A kind of nutritional preparation repaired for kidney cell, it is characterised in that extracted by Rhizoma Polygonati
Thing, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol etc. are natural
Functional component forms；Based on its parts by weight, wherein Rhizoma Polygonati extract 10kg, Radix Ginseng extract 6kg, Fructus Rubi extract
11kg, Concha Ostreae extract 16kg, Maca extract 7kg, fine peptide powder 14kg, soybean peptide 15kg, plant sterol 6kg.
The preparation method of a kind of nutritional preparation repaired for kidney cell, it is characterised in that should
Method comprises the steps:
(1) by prescription amount weigh Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract,
Fine peptide powder, soybean peptide, plant sterol are raw material；
(2) microcrystalline cellulose excipients 0.5kg, magnesium stearate 0.05kg, silicon dioxide 2kg, mix homogeneously are added；
(3) mixed powder is made tablet.
A kind of nutritional preparation repaired for kidney cell, it is characterised in that extracted by Rhizoma Polygonati
Thing, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extract, Maca extract, fine peptide powder, soybean peptide, plant sterol etc. are natural
Functional component forms；Based on its parts by weight, wherein, Rhizoma Polygonati extract 18kg, Radix Ginseng extract 9kg, Fructus Rubi extract
19kg, Concha Ostreae extract 29kg, Maca extract 9kg, fine peptide powder 30kg, soybean peptide 29kg, plant sterol 10kg.
A kind of preparation method of the nutritional preparation repaired for kidney cell, it is characterised in that
The method comprises the steps: that (1) weighs Rhizoma Polygonati extract, Radix Ginseng extract, Fructus Rubi extract, Concha Ostreae extraction by prescription amount
Thing, Maca extract, fine peptide powder, soybean peptide, plant sterol are raw material；
(2) adjuvant maltodextrin 10kg, starch 8kg, mix homogeneously are added；
(3) mixed powder is made capsule.
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| CN108315177A (en) * | 2018-03-19 | 2018-07-24 | 王海臣 | A kind of medicine-food two-purpose hides careless Tibetan medicine assembled alcoholic drinks and preparation method thereof |
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| CN110917294A (en) * | 2019-12-10 | 2020-03-27 | 李学龙 | Preparation method of high-activity rhizoma polygonati cream |
| CN110934295A (en) * | 2019-12-22 | 2020-03-31 | 重庆申高生化制药股份有限公司 | Composition with body building and kidney nourishing effects and preparation method thereof |
| CN112544990A (en) * | 2020-12-23 | 2021-03-26 | 汤臣倍健股份有限公司 | Composition with reproductive system improving effect and application thereof |
| CN113304243A (en) * | 2021-04-23 | 2021-08-27 | 南方医科大学南方医院 | Application of human hair extracted bioactive peptide in preparation of treatment drug for improving chronic kidney disease protein metabolism and drug |
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| CN108148697A (en) * | 2017-12-31 | 2018-06-12 | 李闯 | One seed oyster ginseng solid beverage and preparation method |
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| CN110934295A (en) * | 2019-12-22 | 2020-03-31 | 重庆申高生化制药股份有限公司 | Composition with body building and kidney nourishing effects and preparation method thereof |
| CN112544990A (en) * | 2020-12-23 | 2021-03-26 | 汤臣倍健股份有限公司 | Composition with reproductive system improving effect and application thereof |
| CN113304243A (en) * | 2021-04-23 | 2021-08-27 | 南方医科大学南方医院 | Application of human hair extracted bioactive peptide in preparation of treatment drug for improving chronic kidney disease protein metabolism and drug |
| CN113304243B (en) * | 2021-04-23 | 2023-07-04 | 南方医科大学南方医院 | Application of human hair extracted bioactive peptide in preparing medicine for improving chronic kidney disease protein metabolism and medicine |
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