CN110917294A - Preparation method of high-activity rhizoma polygonati cream - Google Patents
Preparation method of high-activity rhizoma polygonati cream Download PDFInfo
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- 230000000694 effects Effects 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000006071 cream Substances 0.000 title claims description 11
- 239000007787 solid Substances 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 25
- 102000004190 Enzymes Human genes 0.000 claims abstract description 18
- 108090000790 Enzymes Proteins 0.000 claims abstract description 18
- 239000004480 active ingredient Substances 0.000 claims abstract description 18
- 238000006243 chemical reaction Methods 0.000 claims abstract description 18
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- 238000003756 stirring Methods 0.000 claims abstract description 14
- 150000004676 glycans Chemical class 0.000 claims abstract description 12
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 12
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- 239000005017 polysaccharide Substances 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 230000007062 hydrolysis Effects 0.000 claims abstract description 11
- 150000005856 steroid saponins Chemical class 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims abstract description 9
- 241000037831 Polygonatum sibiricum Species 0.000 claims abstract description 6
- 238000003860 storage Methods 0.000 claims description 11
- 230000006837 decompression Effects 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 239000008213 purified water Substances 0.000 claims description 6
- 238000002791 soaking Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241000234280 Liliaceae Species 0.000 claims description 3
- 241000037826 Polygonatum kingianum Species 0.000 claims description 3
- 241001468611 Polygonatum cyrtonema Species 0.000 claims description 2
- 238000004321 preservation Methods 0.000 claims description 2
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention provides a preparation method of high-activity rhizoma polygonati paste, which comprises the preparation processes of extraction of rhizoma polygonati active ingredients, enzyme hydrolysis conversion reaction of rhizoma polygonati, filtration of a microporous membrane, reduced pressure concentration, secondary conversion of the rhizoma polygonati active ingredients and the like. Extracting the active ingredients of the polygonatum sibiricum at 85-90 ℃ for 2-6 h; the temperature of the reaction for hydrolyzing and converting the flavoenzyme is 25-40 ℃, and the reaction lasts for 1-4 h; the filtering pressure of the microporous membrane is 0.3-0.5 MPa, and the filtering aperture of the microporous membrane is 1-5 mu m; the reduced pressure concentration temperature is 60-75 ℃, the vacuum degree is-0.06-0.08 Mpa, until the solid content is 30-35 percent; and (2) carrying out secondary conversion on the active ingredients of the rhizoma polygonati to 85-90 ℃, stirring at normal pressure and keeping the temperature for 8-12 h, carrying out reduced pressure concentration under the vacuum degree of-0.05-0.07 Mpa, repeating the steps until the solid content is 60-65%, and finishing concentration to obtain the high-activity rhizoma polygonati paste, wherein the content of the active ingredients such as rhizoma polygonati polysaccharide, rhizoma polygonati steroid saponin and the like in the method is improved by more than 30% compared with that of the rhizoma polygonati paste prepared by the conventional method.
Description
Technical Field
The invention belongs to the field of medicine, health-care food and food processing, and particularly provides a preparation method of high-activity rhizoma polygonati paste.
Background
Polygonatum sibiricum (Polygonatum sibiricum) is a perennial herb of Liliaceae, and the root and stem of Polygonatum sibiricum are used as medicines, and has been recorded in Ming Dynasty's famous medical records for more than two thousand years. The sealwort has neutral nature and sweet taste, enters spleen, kidney and lung channels, has the effects of tonifying kidney and replenishing essence, relieving epigastric distention and benefiting vital energy, nourishing yin and moistening dryness, promoting the production of body fluid and tonifying spleen and the like, and is long-term applied to the treatment of symptoms such as weakness of spleen and stomach, deficiency of the kidney and deficiency, lung deficiency and dry cough, tiredness and hypodynamia and the like. Modern chemical component analysis shows that the main effective components of rhizoma polygonati include steroid saponin, polysaccharide, oligosaccharide, triterpenoid saponin, flavone and the like. Rhizoma Polygonati is listed in list of articles issued by Ministry of health, which are food and medicine, and has high safety.
At present, the method for processing polygonatum sibiricum at home and abroad mainly comprises the following methods: firstly, rhizoma polygonati is dried and then crushed into particles to be drunk as tea bags; secondly, processing rhizoma polygonati into prepared rhizoma polygonati by adopting a steaming and drying combined method, and using the rhizoma polygonati as an instant food; thirdly, polysaccharide or flavonoid ingredients in the sealwort are singly separated by using an organic solvent and a resin adsorption method, and the sealwort is used for producing medicines. The processing method has the problems of low extraction or conversion degree of active ingredients and nutrient substances of the polygonatum, backward technical method, low automation degree, inconvenient eating mode of products and the like, the due medicinal value and health care effect of the products are difficult to ensure, and the large-scale production and standardized production of the polygonatum are urgently solved to promote the upgrading of the polygonatum industry.
Disclosure of Invention
In order to solve the problems of extensive processing technology, backward technology, low automation degree, low content of high-activity components in rhizoma polygonati, inconvenience for eating and the like in the prior art for processing rhizoma polygonati, the invention develops a preparation method of high-activity rhizoma polygonati paste with mature technical process route, greatly improved active components in rhizoma polygonati, convenience for eating and higher automatic production degree, so as to promote the realization of scale production and standardized production of rhizoma polygonati.
The technical scheme of the invention is as follows:
the preparation method of the high-activity rhizoma polygonati cream is characterized by comprising the following specific steps:
(1) extracting active ingredients of rhizoma polygonati: slicing the washed rhizoma polygonati, then placing the sliced rhizoma polygonati in a forced external circulation type extraction tank, adding purified water with the weight being 8-12 times that of the rhizoma polygonati, soaking for 2-4 h, starting a steam valve and a circulating pump, enabling the temperature of an extracting solution to reach 85-90 ℃, and dynamically and circularly extracting for 2-6 h; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) carrying out enzyme hydrolysis conversion reaction on rhizoma polygonati: keeping the temperature of the rhizoma polygonati extract in the temporary storage tank to 25-40 ℃, adding fresh rhizoma polygonati blocks accounting for 1-5% of the weight of the extract, and performing enzyme hydrolysis conversion reaction on the rhizoma polygonati by using natural biological enzyme existing in rhizoma polygonati tubers and keeping the temperature for 1-4 hours at 25-40 ℃;
(3) filtering with a microporous membrane: conveying the extracting solution at high pressure and passing through a microporous membrane filter, wherein the pressure of a conveying pump is 0.3-0.5 MPa, and conveying the filtrate to a vacuum reduced pressure concentrator;
(4) and (3) concentrating under reduced pressure: controlling the parameters of a vacuum decompression concentrator, and carrying out decompression concentration on the sealwort conversion extract until the content of solid matters is 30-35% Brix (w/w), wherein the concentration temperature is 60-75 ℃, and the vacuum degree is-0.06-0.08 Mpa;
(5) and (3) secondary conversion of active ingredients of rhizoma polygonati: placing sealwort concentrated solution with the solid content of 30-35% Brix (w/w) in a scraper type concentration tank, adjusting the temperature to 85-90 ℃, stirring at normal pressure and keeping the temperature for 8-12 h, starting a vacuum pump, adjusting the vacuum degree to-0.05-0.07 Mpa, and carrying out reduced pressure concentration; repeating the steps for a plurality of times until the solid content is 60-65% Brix (w/w), and finishing concentration to obtain the high-activity rhizoma polygonati paste.
As a preferred technical scheme:
in the step (1), the slice thickness of the rhizoma polygonati is 0.5-1 cm.
In the step (2), the size of the fresh rhizoma polygonati blocks is a cube or a cuboid with the side length of 0.5-1 cm.
In the step (3), the filtering pore diameter of the microporous membrane filter is 1-5 μm.
In the step (5), the stirring and heat preservation under normal pressure and the concentration under reduced pressure are carried out for three times, the first concentration under reduced pressure is carried out until the solid content is 40-45% Brix (w/w), the second concentration under reduced pressure is carried out until the solid content is 45-50% Brix (w/w), and the third concentration under reduced pressure is carried out until the solid content is 60-65% Brix (w/w).
The Polygonatum kingianum of the invention comprises dried rhizome of Polygonatum kingianum Coll. et Hemsl, Polygonatum-tum sibiricum Red. or Polygonatum cyrtonema Hua of Liliaceae and processed product thereof.
The invention creatively uses the active enzyme hydrolysis reaction technology, the dynamic circulation extraction technology and the secondary conversion technology of the active ingredients of the sealwort, the processing technology is more advanced, the automation control degree of the production of sealwort products is greatly improved, the physical and chemical index stability of the products is increased, and the product quality is obviously improved. The invention optimizes the preparation process parameters of the high-activity rhizoma polygonati paste, defines the reaction temperature and time of natural rhizoma polygonati enzyme on rhizoma polygonati polysaccharide, steroid saponin, protein, starch and other substances, converts high-activity components such as rhizoma polygonati polysaccharide, steroid saponin and the like to the maximum extent, effectively improves the content of the high-activity components rhizoma polygonati polysaccharide and rhizoma polygonati steroid saponin in the rhizoma polygonati paste, wherein the content of the rhizoma polygonati polysaccharide is more than or equal to 6 percent, the content of the rhizoma polygonati steroid saponin is more than or equal to 1.0 percent, and the content of the active components in the rhizoma polygonati paste is improved by more than 30 percent compared. The invention overcomes the defects of extensive steaming and drying method, fussy manual manufacturing procedure, low quality standardization degree and the like in the traditional processing method of the rhizoma polygonati, and the implementation of the invention is beneficial to improving the additional value of the rhizoma polygonati industry and promoting the development of modernization of traditional Chinese medicine processing.
Detailed Description
Example 1
(1) Extracting active ingredients of rhizoma polygonati: slicing cleaned rhizoma Polygonati with thickness of 0.5cm, placing in forced external circulation type extraction tank, adding purified water 8 times of rhizoma Polygonati, soaking for 2 hr, opening steam valve and circulation pump, extracting the extractive solution at 85 deg.C, dynamically and circularly extracting for 2 hr; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) carrying out enzyme hydrolysis conversion reaction on rhizoma polygonati: keeping the temperature of the rhizoma polygonati extract in the temporary storage tank to 25 ℃, adding fresh rhizoma polygonati blocks accounting for 1 percent of the weight of the extract, wherein the rhizoma polygonati blocks are cubes with the side length of 0.5cm, and performing enzyme hydrolysis conversion reaction on the rhizoma polygonati by utilizing natural biological enzyme existing in rhizoma polygonati tubers and keeping the temperature at 25 ℃ for 1 h;
(3) filtering with a microporous membrane: conveying the extractive solution under high pressure through microporous membrane filter, wherein the pressure of the conveying pump is 0.3MPa, the pore diameter of the membrane filter is 1 μm, and conveying the filtrate to vacuum concentrator;
(4) and (3) concentrating under reduced pressure: controlling parameters of a vacuum decompression concentrator, concentrating at 60 deg.C under-0.06 Mpa, and vacuum-concentrating the rhizoma Polygonati conversion extract until the solid content is 30% Brix (w/w);
(5) and (3) secondary conversion of active ingredients of rhizoma polygonati: placing rhizoma Polygonati concentrated solution with solid content of 30% Brix (w/w) in scraper type concentration tank, adjusting temperature to 85 deg.C, stirring under normal pressure and maintaining temperature for 8h, starting vacuum pump, adjusting vacuum degree to-0.05 Mpa, and concentrating under reduced pressure until solid content is 40% Brix (w/w). Then repeating the steps of adjusting the temperature to 85 ℃, stirring and preserving the temperature for 8h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.05 Mpa, and carrying out reduced pressure concentration until the solid content is 45% Brix (w/w). Repeating the steps of adjusting the temperature to 85 ℃, stirring and preserving the temperature for 8h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.05 Mpa, and carrying out reduced pressure concentration until the solid content is 60% Brix (w/w). Concentrating to obtain high-activity rhizoma Polygonati extract with rhizoma Polygonati polysaccharide content of 6.2% and rhizoma Polygonati steroid saponin content of 1.1%.
Example 2
(1) Extracting active ingredients of rhizoma polygonati: slicing cleaned rhizoma Polygonati with thickness of 1cm, placing in forced external circulation type extraction tank, adding purified water 12 times of rhizoma Polygonati, soaking for 4 hr, opening steam valve and circulation pump, extracting the extractive solution at 90 deg.C for 6 hr in dynamic circulation manner; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) carrying out enzyme hydrolysis conversion reaction on rhizoma polygonati: keeping the temperature of the rhizoma polygonati extract in the temporary storage tank to 40 ℃, adding fresh rhizoma polygonati blocks accounting for 5 percent of the weight of the extract, wherein the rhizoma polygonati blocks are cubes with the side length of 1cm, and performing enzyme hydrolysis conversion reaction on the rhizoma polygonati by utilizing natural biological enzyme existing in rhizoma polygonati tubers and keeping the temperature for 4 hours at 40 ℃;
(3) filtering with a microporous membrane: conveying the above extractive solution under high pressure through microporous membrane filter, wherein the pressure of the conveying pump is 0.5MPa, the pore diameter of the membrane filter is 5 μm, and conveying the filtrate to vacuum concentrator;
(4) and (3) concentrating under reduced pressure: controlling parameters of a vacuum decompression concentrator, concentrating at 75 deg.C under-0.08 Mpa, and vacuum-concentrating the rhizoma Polygonati conversion extract until the solid content is 35% Brix (w/w);
(5) and (3) secondary conversion of active ingredients of rhizoma polygonati: placing rhizoma Polygonati concentrated solution with solid content of 35% Brix (w/w) in scraper type concentration tank, adjusting temperature to 90 deg.C, stirring under normal pressure, maintaining the temperature for 12h, starting vacuum pump, adjusting vacuum degree to-0.07 Mpa, and concentrating under reduced pressure until solid content is 45% Brix (w/w). Then repeating the steps of adjusting the temperature to 90 ℃, stirring and preserving the temperature for 12h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.07 Mpa, and carrying out reduced pressure concentration until the solid content is 50% Brix (w/w). Repeating the steps of adjusting the temperature to 90 ℃, stirring and preserving the temperature for 12h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.07 Mpa, and carrying out reduced pressure concentration until the solid content is 65% Brix (w/w). Concentrating to obtain high-activity rhizoma Polygonati extract with rhizoma Polygonati polysaccharide content of 6.1% and rhizoma Polygonati steroid saponin content of 1.1%.
Example 3
(1) Extracting active ingredients of rhizoma polygonati: slicing cleaned rhizoma Polygonati with thickness of 0.75cm, placing in forced external circulation type extraction tank, adding 10 times of purified water, soaking for 3 hr, opening steam valve and circulation pump, extracting the extractive solution at 90 deg.C for 5 hr; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) carrying out enzyme hydrolysis conversion reaction on rhizoma polygonati: keeping the temperature of the rhizoma polygonati extract in the temporary storage tank to 36 ℃, adding fresh rhizoma polygonati blocks accounting for 3 percent of the weight of the extract, wherein the rhizoma polygonati blocks are cubes with the side length of 0.75cm, and performing enzyme hydrolysis conversion reaction on the rhizoma polygonati by utilizing natural biological enzyme existing in rhizoma polygonati tubers and keeping the temperature for 4 hours at 36 ℃;
(3) filtering with a microporous membrane: conveying the above extractive solution under high pressure through microporous membrane filter, wherein the pressure of the conveying pump is 0.5MPa, the pore diameter of the membrane filter is 5 μm, and conveying the filtrate to vacuum concentrator;
(4) and (3) concentrating under reduced pressure: controlling parameters of a vacuum decompression concentrator, concentrating at 70 deg.C under-0.06 Mpa, and vacuum-concentrating the rhizoma Polygonati conversion extract until the solid content is 32% Brix (w/w);
(5) and (3) secondary conversion of active ingredients of rhizoma polygonati: placing rhizoma Polygonati concentrated solution with solid content of 32% Brix (w/w) in scraper type concentration tank, adjusting temperature to 88 deg.C, stirring under normal pressure and maintaining temperature for 10h, starting vacuum pump, adjusting vacuum degree to-0.07 Mpa, and concentrating under reduced pressure until solid content is 42% Brix (w/w). Then repeating the steps of adjusting the temperature to 88 ℃, stirring and preserving the temperature for 10h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.07 Mpa, and carrying out reduced pressure concentration until the solid content is 50% Brix (w/w). Repeating the steps of adjusting the temperature to 88 ℃, stirring and preserving the temperature for 10h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.07 Mpa, and carrying out reduced pressure concentration until the solid content is 62% Brix (w/w). Concentrating to obtain high-activity rhizoma Polygonati extract with rhizoma Polygonati polysaccharide content of 7.0% and rhizoma Polygonati steroid saponin content of 1.2%.
Comparative example
(1) Extracting active ingredients of rhizoma polygonati: slicing cleaned rhizoma Polygonati with thickness of 0.75cm, placing in forced external circulation type extraction tank, adding 10 times of purified water, soaking for 3 hr, opening steam valve and circulation pump, extracting the extractive solution at 90 deg.C for 5 hr; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) filtering with a microporous membrane: conveying the above extractive solution under high pressure through microporous membrane filter, wherein the pressure of the conveying pump is 0.5MPa, the pore diameter of the membrane filter is 5 μm, and conveying the filtrate to vacuum concentrator;
(3) and (3) concentrating under reduced pressure: controlling parameters of a vacuum concentration device, concentrating at 70 deg.C under-0.06 Mpa, and concentrating the rhizoma Polygonati conversion extractive solution under reduced pressure until the solid content is 65% Brix (w/w), to obtain rhizoma Polygonati extract, wherein the rhizoma Polygonati polysaccharide content is 3.5%, and rhizoma Polygonati steroid saponin content is 0.6%.
The invention is not the best known technology.
The above embodiments are merely illustrative of the technical ideas and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the contents of the present invention and implement the present invention, and not to limit the protection scope of the present invention. All equivalent changes and modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.
Claims (7)
1. The preparation method of the high-activity rhizoma polygonati cream is characterized by comprising the following specific steps:
(1) extracting active ingredients of rhizoma polygonati: slicing the washed rhizoma polygonati, then placing the sliced rhizoma polygonati in a forced external circulation type extraction tank, adding purified water with the weight being 8-12 times that of the rhizoma polygonati, soaking for 2-4 h, starting a steam valve and a circulating pump, enabling the temperature of an extracting solution to reach 85-90 ℃, and dynamically and circularly extracting for 2-6 h; extracting the filtered rhizoma polygonati residues once again according to the process parameters, combining the two extracting solutions, and placing the extracting solutions in a temporary storage tank;
(2) carrying out enzyme hydrolysis conversion reaction on rhizoma polygonati: keeping the temperature of the rhizoma polygonati extract in the temporary storage tank to 25-40 ℃, adding fresh rhizoma polygonati blocks accounting for 1-5% of the weight of the extract, and performing enzyme hydrolysis conversion reaction on the rhizoma polygonati by using natural biological enzyme existing in rhizoma polygonati tubers and keeping the temperature for 1-4 hours at 25-40 ℃;
(3) filtering with a microporous membrane: conveying the extracting solution at high pressure and passing through a microporous membrane filter, wherein the pressure of a conveying pump is 0.3-0.5 MPa, and conveying the filtrate to a vacuum reduced pressure concentrator;
(4) and (3) concentrating under reduced pressure: controlling the parameters of a vacuum decompression concentrator, and carrying out decompression concentration on the sealwort conversion extract until the content of solid matters is 30-35% Brix (w/w), wherein the concentration temperature is 60-75 ℃, and the vacuum degree is-0.06-0.08 Mpa;
(5) and (3) secondary conversion of active ingredients of rhizoma polygonati: placing the sealwort concentrated solution with the solid content of 30-35% in a scraper type concentration tank, adjusting the temperature to 85-90 ℃, stirring and preserving the temperature for 8-12 h under normal pressure, starting a vacuum pump, adjusting the vacuum degree to-0.05-0.07 Mpa, and carrying out reduced pressure concentration; repeating the steps for a plurality of times until the solid content is 60-65%, and obtaining the high-activity rhizoma polygonati cream after the concentration is finished.
2. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: in the step (1), the slice thickness of the rhizoma polygonati is 0.5-1 cm.
3. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: in the step (2), the size of the fresh rhizoma polygonati blocks is a cube or a cuboid with the side length of 0.5-1 cm.
4. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: in the step (3), the filtering pore diameter of the microporous membrane filter is 1-5 μm.
5. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: in the step (5), stirring and heat preservation under normal pressure and vacuum concentration are carried out for three times, the first vacuum concentration is carried out until the content of the solid matters is 40% -45%, the second vacuum concentration is carried out until the content of the solid matters is 45% -50%, and the third vacuum concentration is carried out until the content of the solid matters is 60% -65%.
6. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: the rhizoma Polygonati comprises dried rhizome of Polygonatum kingianum, Polygonatum sibiricum or Polygonatum cyrtonema of Liliaceae, and processed product thereof.
7. The method for preparing high-activity rhizoma polygonati cream according to claim 1, wherein the method comprises the following steps: the obtained high-activity rhizoma Polygonati extract contains rhizoma Polygonati polysaccharide more than 6% and rhizoma Polygonati steroid saponin more than 1.0%.
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| CN102284005A (en) * | 2011-09-08 | 2011-12-21 | 厦门鹰君药业有限公司 | Preparation method of sealwort and longan paste |
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| CN106110291A (en) * | 2016-06-29 | 2016-11-16 | 中科和素（天津）医药科技有限公司 | A kind of nutritional preparation for kidney cell reparation and preparation method thereof |
| CN109846940A (en) * | 2019-01-31 | 2019-06-07 | 皖西学院 | A kind of Siberian solomonseal rhizome polysaccharide extract and its extracting method and purposes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102284005A (en) * | 2011-09-08 | 2011-12-21 | 厦门鹰君药业有限公司 | Preparation method of sealwort and longan paste |
| CN103479875A (en) * | 2013-08-28 | 2014-01-01 | 刘宏非 | Preparation method and application of high-activity radix polygonati officinalis concentrated solution |
| CN106110291A (en) * | 2016-06-29 | 2016-11-16 | 中科和素（天津）医药科技有限公司 | A kind of nutritional preparation for kidney cell reparation and preparation method thereof |
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