CN109846940A - A kind of Siberian solomonseal rhizome polysaccharide extract and its extracting method and purposes - Google Patents
A kind of Siberian solomonseal rhizome polysaccharide extract and its extracting method and purposes Download PDFInfo
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- rhizoma polygonati
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Abstract
The invention discloses a kind of Siberian solomonseal rhizome polysaccharide extract and its extracting methods and purposes, rhizoma polygonati is through dried and crushed, through adding water, enzyme ultrasound enzymatic hydrolysis, filtering and concentrating, ethyl alcohol concentration, decoloration, it is dried in vacuo to obtain rhizoma polygonati xeraphium, and water purifies to obtain Siberian solomonseal rhizome polysaccharide powder, the present invention is high-efficient to Polyose extraction, the purity is high of extraction, available polyoses content is the rhizoma polygonati xeraphium of 92.9-95.7%, available polyoses content is the white powder Siberian solomonseal rhizome polysaccharide powder of 96.5-99.3, low temperature extraction is carried out to polysaccharide in extraction process, and it is extracted through enzyme and ultrasound, rhizoma polygonati can be made effective use of and be extracted, and it is vacuum dried, uniform drying, disinfection, sterilization, and it is further purified through deionized water, improve polyoses content and quality, the homeostasis balance of birds can be significantly increased, enhancing machine The detoxification ability of body, eliminating toxin influences, and improves the anti-oxidant anti-aging ability of body.
Description
Technical field
The present invention relates to rhizoma polygonati extractive technique field, specific more particularly to a kind of extracting method of Siberian solomonseal rhizome polysaccharide.
Background technique
Rhizoma polygonati (scientific name: Polygonatum sibiricum), also known as: polygonatum sibiricum Redoute, yellow chicken dish, pen tube dish, claw ginseng,
Tendrilleaf solomonseal rhizome, achickenclaw ginseng.For Angiospermae, Monocotyledonae, Liliales, Liliaceae, HUANGJING ZANYU CAPSULE.Rhizome it is horizontal walk, circle
Column, tubercle expand.Impeller generator, stockless.Medicinal plant has tonifying spleen, the effect of moistening lung and producing body fluid.Main active component is drying
Rhizome, nature and flavor are sweet, flat, and returns spleen, lung, kidney channel have the effect of boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing, and in addition to this rhizoma polygonati is also
It with blood glucose, blood lipid is adjusted, enhances human immunity, antifatigue and anti-aging effect.Mainly produced in Heilungkiang, Jilin, the Liao Dynasty
Rather, Hebei, Shanxi, Shaanxi, the Inner Mongol, Ningxia, Gansu (east), Henan, Shandong, Anhui (east), Zhejiang (northwestward).It is raw
At hayashishita, shrubbery or hillside yin, 800-2800 meters of height above sea level.Korea, Mongolia and Soviet Union's eastern Siberia area also have.Modern medicine
Pharmacological research shows that its active constituent is mainly Siberian solomonseal rhizome polysaccharide (polygonatum sibiticumpolysaccharides.
PSP), Siberian solomonseal rhizome polysaccharide has the effects that antitumor, anti-aging, immunological regulation and anti-oxidative damage as other polysaccharide, and
And the polyoses content in rhizoma polygonati is generally 10% or more, therefore the Study on extraction of Siberian solomonseal rhizome polysaccharide has the development and utilization of rhizoma polygonati
It is significant.
Rhizoma polygonati is the Chinese medicine of Chinese tradition, belongs to integration of drinking and medicinal herbs Chinese herbal medicine.Rhizoma polygonati is as a kind of traditional rare Chinese medicine, tool
Have regulating and tonifying qi, enriching kidney essence, nourishing Yin and moistening lung, promote the production of body fluid tonifying spleen the effect of ridicule, there are many kinds of the extracting methods of plant polyose, including
Solvent acid formulation, extraction method, alkaline extraction, ultrafiltration, enzymatic isolation method, ultrafiltration etc., Siberian solomonseal rhizome polysaccharide is also one of plant polyose,
According to other characteristics such as its dissolubility, the extracting method currently used for extracting Siberian solomonseal rhizome polysaccharide mainly includes that hot water extracts, alcohol analysis divides
From assisted extraction method has microwave radiation exaraction, ultrasonic wave extraction etc., but recovery rate is not high, and extraction step is complicated, mentions
The purity of polysaccharide taken is not high, and multiple high temp separates, and the validity of polysaccharide is caused to substantially reduce.
That there are preparations is extensive for existing birds powder, and dosage is big, problem at high cost, though new formulation convenient drug administration,
The problem that there is also extraction efficiencies is lower, production cost is higher, quality control difficulty is larger, so birds preparation is badly in need of a kind of side
Just it uses, is at low cost, the novel birds preparation that drug effect is high.
Summary of the invention
For this purpose, the present invention proposes a kind of Siberian solomonseal rhizome polysaccharide extract and its extracting method and purposes, the recovery rate of polysaccharide is improved,
The validity of polysaccharide is improved, destruction of the existing method to polysaccharide is reduced, simplifies operating procedure, the homeostasis of birds can be significantly increased
Balance enhances the detoxification ability of body, and eliminating toxin influences, and improves the anti-oxidant anti-aging ability of body.
The present invention is realized by following means:
A kind of extracting method of Siberian solomonseal rhizome polysaccharide, comprising the following steps:
(1) raw sealwort is cleaned up and is dried, be sliced and crush after drying, powder particle diameter is 6-15 microns, is then added
Rhizoma polygonati: pure water mass ratio is and cellulase, protease to be added, and be heated to 48-52 DEG C, through power in the pure water of 1:28-32
10-15min is digested for the ultrasonic wave of 60-80W；
(2) through vibration screen device filtering after the rhizoma polygonati solution of above-mentioned processing is cooling, pore size filter is 1-3 microns, then will
Filtrate by above-mentioned filtering carries out ultrafiltration through ceramic membrane, reverse osmosis membrane, obtains rhizoma polygonati crude extract concentrate；
(3) ethyl alcohol that obtained rhizoma polygonati crude extract concentrate is added to the 80-90% of 3-6 times of its weight takes off
Rouge recycles ethyl alcohol, further obtains rhizoma polygonati concentrate；
(4) deionized water of its 2-4 times of volume is added in Xiang Shangshu rhizoma polygonati concentrate, and 0.6% active carbon progress is added
Decoloration, temperature control controls time 8-10min at 52-54 DEG C when activated carbon adsorption, decolourizes number 2-4 times；
(5) the rhizoma polygonati concentrate after decoloration is transported in vacuum oven through high pressure concentrating pump, vacuum degree 100-
200Pa, and radiate rhizoma polygonati concentrate to be dried through microwave generator, dry preliminary rhizoma polygonati xeraphium；
(6) deionized water is added in above-mentioned rhizoma polygonati xeraphium and its weight ratio is to be heated to 70- in the deionized water of 30:1
80 DEG C, heating time 2-2.5h, then the pure liquid of rhizoma polygonati will be obtained, so through treated extracting solution through biofilm filtration
The pure liquid of rhizoma polygonati is purified and dried using conventional method afterwards, obtains Siberian solomonseal rhizome polysaccharide powder.
The Siberian solomonseal rhizome polysaccharide powder that the present patent application method obtains is white powder, polyoses content 96.5-99.3%.
The preliminary rhizoma polygonati xeraphium that the present patent application method obtains is white powder, polyoses content 92.9-
95.7%, wherein 3.8% is promoted using step (6) maximum polyoses content, average enhancing rate 3.6%.
The cellulase, protease ratio be 1:1, cellulase, protease total addition level be 0.9%.
Purposes of the material of following weight proportion in the drug that preparation improves poultry immunity and detoxification ability: polysaccharide contains
Amount is 12 parts of 96.5-99.3% Siberian solomonseal rhizome polysaccharide, 10 parts of Radix Glycyrrhizae, 9 parts of coptis root, 9 parts of Rhizoma Atractylodis Macrocephalae.
The drug is that polyoses content is that 96.5-99.3% Siberian solomonseal rhizome polysaccharide and use water or extractive with organic solvent extraction are sweet
Grass, coptis root, Rhizoma Atractylodis Macrocephalae active constituent, and it is equipped with the auxiliary material for meeting national Chinese medicine integration of drinking and medicinal herbs standard or medicine is prepared in auxiliary element
Agent.
The medicament is paste, granule, powder.
The beneficial effects of the present invention are: the method for the invention is high-efficient to Polyose extraction, the purity is high of extraction can be obtained
The rhizoma polygonati xeraphium for being 92.9-95.7% to polyoses content, available polyoses content are the white powder of 96.5-99.3%
Siberian solomonseal rhizome polysaccharide powder carries out low temperature extraction to polysaccharide in extraction process, and extracts through enzyme and ultrasound, and rhizoma polygonati can be filled
Divide and efficiently use and extract, and vacuum dried, uniform drying, disinfection, sterilization, and further purified through deionized water, so that
Active principle further releases in Siberian solomonseal rhizome polysaccharide, improves active constituent content, and effectively increase the purifying of rhizoma polygonati, improves
Polyoses content and quality, Siberian solomonseal rhizome polysaccharide pharmaceutical composition of the present invention can significantly increase the homeostasis balance of birds, enhance body
Detoxification ability, eliminating toxin influences, and improves the anti-oxidant anti-aging ability of body.
Specific embodiment:
In order to make those skilled in the art more fully understand technical solution of the present invention, below with reference to embodiment to this hair
It is bright to be described further:
A kind of extracting method of Siberian solomonseal rhizome polysaccharide, comprising the following steps: raw sealwort is cleaned up and dried, is sliced after drying
It crushes, powder particle diameter is 6-15 micron, and rhizoma polygonati is then added: is and cellulose is added in the pure water of 1:28-32 in pure water mass ratio
Enzyme, protease, and it is heated to 48-52 DEG C, 10-15min is digested through the ultrasonic wave that power is 60-80W；Rhizoma polygonati through above-mentioned processing
Through vibration screen device filtering after solution is cooling, pore size filter is 1-3 microns, then by the filtrate Jing Guo above-mentioned filtering through ceramic membrane,
Reverse osmosis membrane carries out ultrafiltration, obtains rhizoma polygonati crude extract concentrate；By obtained rhizoma polygonati crude extract concentrate be added 3-6 times its
The ethyl alcohol of the 80-90% of weight carries out degreasing, recycles ethyl alcohol, further obtains rhizoma polygonati concentrate；Add to above-mentioned rhizoma polygonati concentrate
Enter the deionized water of its 2-4 times of volume, and 0.6% active carbon is added and decolourizes, temperature control is in 52- when activated carbon adsorption
54 DEG C, time 8-10min is controlled, is decolourized number 2-4 times；Rhizoma polygonati concentrate after decoloration is transported to vacuum through high pressure concentrating pump
In drying box, vacuum degree 100-200Pa, and radiate rhizoma polygonati concentrate to be dried through microwave generator, dry preliminary rhizoma polygonati
Xeraphium；Deionized water is added in above-mentioned rhizoma polygonati xeraphium and its weight ratio is to be heated to 70-80 in the deionized water of 30:1
DEG C, then heating time 2-2.5h will obtain the pure liquid of rhizoma polygonati, then through treated extracting solution through biofilm filtration
The pure liquid of rhizoma polygonati is purified and dried using conventional method, obtains Siberian solomonseal rhizome polysaccharide powder.
Embodiment 1
100kg raw sealwort is cleaned up and is dried, after drying be sliced crush, powder particle diameter be 6-15 microns, then plus
Enter rhizoma polygonati: pure water mass ratio is and cellulase, protease to be added, and be heated to 50 DEG C in the pure water of 1:30, be through power
The ultrasonic wave of 65W digests 12min；Through vibration screen device filtering after the rhizoma polygonati solution of above-mentioned processing is cooling, pore size filter is that 1-3 is micro-
Then filtrate Jing Guo above-mentioned filtering is carried out ultrafiltration through ceramic membrane, reverse osmosis membrane, obtains rhizoma polygonati crude extract concentrate by rice
400kg；90% ethyl alcohol that 4 times of its weight are added in obtained rhizoma polygonati crude extract concentrate is subjected to degreasing, recycles ethyl alcohol,
Further obtain rhizoma polygonati concentrate；The deionized water of its 3 times of volumes is added to above-mentioned rhizoma polygonati concentrate, and 0.6% work is added
Property charcoal decolourize, temperature control controls time 9min at 53 DEG C when activated carbon adsorption, decolourizes number 2 times；By the Huang after decoloration
Smart concentrate is transported in vacuum oven through high pressure concentrating pump, vacuum degree 100-200Pa, and through microwave generator radiation to
Dry rhizoma polygonati concentrate, it is dry that preliminary rhizoma polygonati xeraphium 19.1kg, rhizoma polygonati xeraphium contain sugar 94.62%；Above-mentioned rhizoma polygonati is done
Deionized water is added in dry powder and its weight ratio is to be heated to 70 DEG C, heating time 2h in the deionized water of 30:1, then will be through upper
Extracting solution of stating that treated is obtained the pure liquid of rhizoma polygonati, is then purified using conventional method to the pure liquid of rhizoma polygonati through biofilm filtration
And it is dry, Siberian solomonseal rhizome polysaccharide powder 18.8kg is obtained, containing sugar 98.24%.
Anthrone-sulphuric acid method measures polyoses content, and it is accurate weigh in 50 DEG C of dry dextrose standard sample 0.1g to constant weight in
In 1000mL volumetric flask, the standard solution that concentration is 0.1mg/mL is obtained, takes certain volume standard solution to distinguish compound concentration to be
0.02,0.04,0.06,0.08,0.1mg/mL standard solution measure above-mentioned concentration standard solution in 584n using anthrone-sulphuric acid method
Absorbance under wavelength, takes maximum absorbance, with standard glucose concentration (mg/mL) for abscissa, using absorbance as ordinate,
Standard curve is obtained, obtaining regression equation is y=8.9148x+0.0691, and related coefficient 0.994 shows to measure absorbance and mark
Quasi- concentration of glucose be in good linear relationship, take 1ml Siberian solomonseal rhizome polysaccharide solution crude product in the light of actual conditions dilute certain multiple with
Afterwards, Siberian solomonseal rhizome polysaccharide content, the concentration of polysaccharide after being diluted by regression equation calculation are measured using sulfuric acid anthrone method, and it is dry to change rhizoma polygonati
The solid-to-liquid ratio of dry powder and deionized water, heating time, extraction time carry out research step (5) (6) and promote function to Siberian solomonseal rhizome polysaccharide purity
Effect；Specific data can be found in following table:
As can be known from the above table: solid-to-liquid ratio is l ︰ 30 in the present patent application, Extracting temperature is 70 DEG C, extraction time 2h, is extracted
Number is 1 time；Solid-to-liquid ratio l ︰ 30,80 DEG C of Extracting temperature, extraction time 2.5h, to the purification efficiency highest average of rhizoma polygonati xeraphium
Recovery rate is 3.8%, general to improve average rate 3.6%, extracts Siberian solomonseal rhizome polysaccharide content, is obviously improved.
Embodiment 2
The birds for choosing clinical onset, are randomly divided into control group (D), test group (S) and feminine gender under identical rearing conditions
Control group (Y), and choose normal birds as normal group (Z), every group 40；Control group feeds city by 10g/ dosage spice
It sells coptis root removing toxic substances to dissipate, 2 times a day, be used in conjunction 4 days；Drug granule of the present invention prepared by test group embodiment 1 presses 10g/ dosage
Spice feeding is commercially available, 2 times a day, is used in conjunction 4 days；Negative control group is raised by daily feeding manner, is not administered.Efficacy determination side
Method: it after medication 4 days, observes sick fowl spirit appetite behavior and acquires vena cava anterior blood, separate serum, measure glutamic-pyruvic transaminase
(GPT), glutamic-oxalacetic transaminease (GOT), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX).
From the point of view of above-mentioned experimental data, the birds spirit appetite that medicine group of the present invention is combined is dissipated significantly better than coptis root righting
Group, in terms of transaminase and Antioxidant Indexes, pharmaceutical composition of the present invention is significantly lower than negative group, illustrates that pharmaceutical composition of the present invention can be shown
The homeostasis balance for writing enhancing birds, enhances the detoxification ability of body, and eliminating toxin influences, and improves the anti-oxidant anti-aging of body
Ability.
It is above that certain exemplary embodiments of the invention are only described by way of explanation, undoubtedly, for ability
The those of ordinary skill in domain without departing from the scope of the invention can be with a variety of different modes to described reality
Example is applied to be modified.Therefore, foregoing description is regarded as illustrative in nature, and should not be construed as protecting model to the claims in the present invention
The limitation enclosed.
Unless otherwise defined, all academic and scientific terms used herein have the technical field of the invention common
The identical meanings that technical staff is understood.
In the case where inconsistent, the definition in this specification shall prevail.
Unless otherwise indicated, all percentage, number, ratio etc. are by weight.
When providing numerical value or numberical range, preferred scope or a series of lower preferable values and upper limit preferred value, should manage
It is solved to specifically disclose by any of any lesser range limit or preferred value and any biggish range limit or preferred value
One logarithm is formed by any range, regardless of whether range is disclosed respectively.Unless otherwise indicated, it is described in this specification
In place of numberical range, the range is intended to include all integers and score in range endpoints and range.
When term " about " or " left and right " are used to describe the end value of number value or range, disclosure of that should be include this
Specific value or related end value.
Element and component of the invention are described using the usage of " one " and "/kind ", this only for it is convenient and in order to
Provide ordinary circumstance of the present invention.Unless otherwise obvious statement, which should be interpreted as include/kind or at least one/kind.
Claims (6)
1. a kind of Siberian solomonseal rhizome polysaccharide extract, which is characterized in that it is the white powder that polyoses content is 96.5-99.3%.
2. a kind of extracting method of Siberian solomonseal rhizome polysaccharide, it is characterised in that: the following steps are included:
(1) raw sealwort being cleaned up and is dried, be sliced and crush after drying, powder particle diameter is 6-15 microns, rhizoma polygonati is then added:
Pure water mass ratio is and cellulase, protease to be added, and be heated to 48-52 DEG C in the pure water of 1:28-32, is 60- through power
The ultrasonic wave of 80W digests 10-15min；
(2) through vibration screen device filtering after the rhizoma polygonati solution of above-mentioned processing is cooling, pore size filter is 1-3 microns, then will be passed through
The filtrate of above-mentioned filtering carries out ultrafiltration through ceramic membrane, reverse osmosis membrane, obtains rhizoma polygonati crude extract concentrate；
(3) ethyl alcohol that obtained rhizoma polygonati crude extract concentrate is added to the 80-90% of 3-6 times of its weight carries out degreasing, returns
Ethyl alcohol is received, rhizoma polygonati concentrate is further obtained；
(4) deionized water of its 2-4 times of volume is added in Xiang Shangshu rhizoma polygonati concentrate, and the active carbon of addition 0.6% decolourizes,
Temperature control controls time 8-10min at 52-54 DEG C when activated carbon adsorption, decolourizes number 2-4 times；
(5) the rhizoma polygonati concentrate after decoloration is transported in vacuum oven through high pressure concentrating pump, vacuum degree 100-200Pa,
And rhizoma polygonati concentrate to be dried is radiated through microwave generator, dry preliminary rhizoma polygonati xeraphium；
(6) deionized water is added in above-mentioned rhizoma polygonati xeraphium and its weight ratio is to be heated to 70-80 in the deionized water of 30:1
DEG C, then heating time 2-2.5h will obtain the pure liquid of rhizoma polygonati, then through treated extracting solution through biofilm filtration
The pure liquid of rhizoma polygonati is purified and dried using conventional method, obtains Siberian solomonseal rhizome polysaccharide powder.
3. a kind of extracting method of Siberian solomonseal rhizome polysaccharide according to claim 2, it is characterised in that: the cellulase, albumen
The ratio of enzyme be 1:1, cellulase, protease total addition level be 0.9%.
4. purposes of the material of following weight proportion in the drug that preparation improves poultry immunity and detoxification ability, feature exist
In: polyoses content is 12 parts of 96.5-99.3% Siberian solomonseal rhizome polysaccharide, 10 parts of Radix Glycyrrhizae, 9 parts of coptis root, 9 parts of Rhizoma Atractylodis Macrocephalae.
5. purposes according to claim 4, it is characterised in that: the drug is that polyoses content is 96.5-99.3% rhizoma polygonati
Polysaccharide extracts Radix Glycyrrhizae, coptis root, Rhizoma Atractylodis Macrocephalae active constituent with using water or extractive with organic solvent, and is equipped with and meets national Chinese medicine medicine food
Medicament is prepared in the auxiliary material or auxiliary element of homologous standard.
6. purposes according to claim 5, it is characterised in that: the medicament is paste, granule, powder.
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| CN112220883A (en) * | 2020-10-22 | 2021-01-15 | 贵州蔚源中药材产业开发有限公司 | Sealwort processing technology |
| CN113101341A (en) * | 2021-03-25 | 2021-07-13 | 中国工程物理研究院材料研究所 | Application of rhizoma polygonati in preparation of medicines for preventing and treating low-dose or/and chronic uranium exposure |
| CN113786453A (en) * | 2021-06-25 | 2021-12-14 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
| CN113817079A (en) * | 2021-11-11 | 2021-12-21 | 云南恩润生物科技发展有限公司 | Extraction method of polygonatum polysaccharide |
| CN114042049A (en) * | 2021-11-30 | 2022-02-15 | 辽宁万嘉医药科技有限公司 | Preparation method of fresh rhizoma polygonati freeze-dried quick-release preparation |
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| CN111228199A (en) * | 2020-04-10 | 2020-06-05 | 工大生物合肥股份有限公司 | Preparation method of sealwort low-temperature extraction and restoration essence |
| CN111793142A (en) * | 2020-08-17 | 2020-10-20 | 江苏农牧科技职业学院 | Ultrasonic-assisted synergistic compound enzyme extraction process for polygonatum sibiricum polysaccharide |
| CN112220883A (en) * | 2020-10-22 | 2021-01-15 | 贵州蔚源中药材产业开发有限公司 | Sealwort processing technology |
| CN113101341A (en) * | 2021-03-25 | 2021-07-13 | 中国工程物理研究院材料研究所 | Application of rhizoma polygonati in preparation of medicines for preventing and treating low-dose or/and chronic uranium exposure |
| CN113786453A (en) * | 2021-06-25 | 2021-12-14 | 广州泽力医药科技有限公司 | Preparation method of polygonatum sibiricum extract rich in polygonatum sibiricum polysaccharide and various active ingredients |
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| CN114042049A (en) * | 2021-11-30 | 2022-02-15 | 辽宁万嘉医药科技有限公司 | Preparation method of fresh rhizoma polygonati freeze-dried quick-release preparation |
| CN114042049B (en) * | 2021-11-30 | 2024-01-23 | 辽宁万嘉医药科技有限公司 | Preparation method of freeze-dried quick-release preparation of fresh rhizoma polygonati |
| CN115531299A (en) * | 2022-03-29 | 2022-12-30 | 安徽富韵生物科技有限公司 | Quality-improving and efficiency-improving method for rhizoma polygonati water extract and application of quality-improving and efficiency-improving method |
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