CN105031290A - Compound dendrobium officinale capsules and preparation method thereof - Google Patents
Compound dendrobium officinale capsules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses compound dendrobium officinale capsules. The compound dendrobium officinale capsules are prepared by the following raw materials in part by weight: 40-45 parts of dendrobium officinale, 30-35 parts of lycium barbarum and 25-30 parts of sealwort. The dendrobium officinale serves as main materials of the compound dendrobium officinale capsules, and the lycium barbarum and the sealwort serve as auxiliary materials of the compound dendrobium officinale capsules; the various raw materials are in synergistic interaction; and the compound dendrobium officinale capsules have health-care effects of increasing immunity and relieving physical fatigue, are convenient to take, can be easily absorbed by human bodies and have huge market potential. The invention also discloses a preparation method of the compound dendrobium officinale capsules. The preparation method comprises the following steps of performing enzymolysis, alcohol extraction, concentration and drying on the dendrobium officinale to obtain dendrobium officinale extract powder; mixing and smashing the lycium barbarum and the sealwort and performing water extraction, concentration and drying on the smashed lycium barbarum and the smashed sealwort to obtain mixture extract powder; and mixing the dendrobium officinale extract powder and the mixture extract powder to obtain the capsules. Steps of the preparation method of the compound dendrobium officinale capsules are simple; requirements on equipment are low; the technology is stable; operability and production efficiency are high; and the compound dendrobium officinale capsules are suitable for industrial production.
Description
Technical field
The present invention relates to Medicines and Health Product technical field, especially relate to a kind of compound dendrobium officinale capsule and preparation method thereof.
Background technology
Herba Dendrobii (Dendrobiumofficinale), belongs to the orchid family, Dendrobium, Herba Dendrobii kind, the perennial herbaceous plant that grows nonparasitically upon another plant.Herba Dendrobii is mainly containing dendrobium polysaccharide, alkaloid, aminoacid, the plurality of active ingredients such as trace element and phenolic compound, there is nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, brain nourishing and eyesight improving, protect the liver mind calming, resolving heat and reducing pathogenic fire, the asthenia of tonifying five ZANG-organs, to make light of one's life by commiting suicide the magical effect of prolonging life, to chronic fatigue syndrome, pneumonopathy, coronary heart disease, nephropathy, chronic hepatopathy, hypertension, hyperlipidemia, hyperglycemia, diabetes, chronic gastropathy, dry syndrome, the diseases such as cancer have definite curative effect and conditioning rehabilitative action, and can body immunity be strengthened, antioxidation, defying age, excessive to tobacco and wine, overwork, night life is excessive, use eye brain overwork, hoarseness, dry mouth and tougue, the rehabilitations such as the deficiency of YIN that decline of old gonosome low force have special efficacy.
Fructus Lycii, containing effective ingredient such as lycium barbarum polysaccharide, betanin, atropine, hyoscyamines, has the effects such as Promote immunity, defying age, antitumor.
Rhizoma Polygonati has boosting qi and nourishing yin, spleen invigorating, lung moistening, and effect of kidney tonifying, is usually used in deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, chronic cough hemoptysis, asthenia of essence and blood, soreness of the waist and knees, and early whitening of beard and hair, interior-heat is quenched one's thirst.
But current Herba Dendrobii, Fructus Lycii, Rhizoma Polygonati all also exist inconvenient eating, effective ingredient is low by the absorption rate of human body, the problems such as effect is not remarkable, if the medicinal efficacy of Herba Dendrobii, Fructus Lycii, Rhizoma Polygonati therefore can be made full use of, developing a kind of is major ingredient with Herba Dendrobii, Fructus Lycii, Rhizoma Polygonati are adjuvant, and the more significant health promoting product of taking convenience, result of use, exists huge market value undoubtedly.
Shen Qing Publication day 2015.04.22, the Chinese patent of application publication number CN104524238A discloses a kind of Herba Dendrobii flower of Radix Notoginseng capsule technology of preparing, its according to Herba Dendrobii, the distinctive medicinal efficacy of flower of Radix Notoginseng Chinese crude drug with, with Herba Dendrobii, flower of Radix Notoginseng for raw material, match quantitative auxiliary material, by corresponding technology of preparation method, be prepared into a kind of Herba Dendrobii flower of Radix Notoginseng capsule health promoting product.Its weak point is: each raw material is made filled capsules after powder, though be convenient to take, the effective active composition in each medicine is not easily absorbed by the body, and utilization rate is low, and it is poor that it takes effect.
Summary of the invention
The object of the present invention is to provide a kind of compatibility reasonable, taking convenience, is easily absorbed by the body, energy enhancing immunity, the compound dendrobium officinale capsule of alleviating physical fatigue.
Present invention also offers a kind of compound dendrobium officinale capsule preparation method thereof, step is simple, low for equipment requirements, process stabilizing, and workable, production efficiency is high, is applicable to suitability for industrialized production.
To achieve these goals, the present invention is by the following technical solutions:
A kind of compound dendrobium officinale capsule, is made up of the raw material of following weight portion: 40 ~ 45 parts of Herba Dendrobii, 30 ~ 35 portions of Fructus Lyciis, 25 ~ 30 parts of Rhizoma Polygonatis.Compound dendrobium officinale capsule of the present invention makes full use of the medicinal efficacy of Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati, take Herba Dendrobii as major ingredient, Fructus Lycii, Rhizoma Polygonati are that adjuvant is made, by the Synergistic of each raw material, there is the health-care effect such as enhancing immunity, alleviating physical fatigue, and taking convenience, be easily absorbed by the body, there is huge market potential.
A kind of compound dendrobium officinale capsule preparation method thereof, comprises the following steps:
(1) prepare burden
Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati is taken by above-mentioned weight, stand-by.
(2) Herba Dendrobii extract powder is prepared
(1) Herba Dendrobii weighed up is cleaned, dries, pulverized, cross 60 ~ 80 mesh sieves and obtain dendrobium officinale powder.
(2) add water be incorporated as the compound enzyme of Herba Dendrobii quality 0.3 ~ 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5 ~ 6, be warming up to 50 ~ 60 DEG C after stirring, 90 ~ 95 DEG C of enzyme denaturing are warming up to, cooling after constant temperature enzymolysis 1 ~ 2h.Effective ingredient in Herba Dendrobii is wrapped in cell wall usually, and cell wall increase effective ingredient from cell to Extraction medium diffusion resistance to mass tranfer, the extraction ratio of effective ingredient can be affected, therefore the present invention by conbined enzymolysis with auxiliary alcohol extracting method to improve the extraction ratio of effective ingredient and the extracting efficiency of alcohol extracting method in Herba Dendrobii, can be made the ingredient degradation such as cellulose, pectin in cell wall and Cytoplasm by enzymolysis, in reduction Herba Dendrobii, effective ingredient is from the resistance to mass tranfer of the diffusion that is situated between to extraction in cell.
(3) regulate pH be 8 ~ 9, then be incorporated as dendrobium officinale powder quality 8 ~ 12 times 75 ~ 80% alcoholic solution, be warming up to 75 ~ 80 DEG C of reflux, extract, 2 times, each 0.5 ~ 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extracting solution.The present invention adopts alcohol extraction to ensure that the effective ingredient in Herba Dendrobii can fully leach, and ethanol can reclaim, and is conducive to reducing costs.
(4) be 1.08 ~ 1.12 (20 DEG C) by extracting solution vacuum concentration to relative density, obtain Herba Dendrobii extractum.
(5) by Herba Dendrobii extractum spraying dry, Herba Dendrobii extract powder is obtained.
(3) mixed material extract powder is prepared
A (), by after Fructus Lycii and Rhizoma Polygonati co-grinding, is incorporated as the water of Fructus Lycii and Rhizoma Polygonati gross mass 10 ~ 12 times, be heated to 100 DEG C of lixiviates 2 times, and each lixiviate 1 ~ 2h, filters and collect filtrate, obtaining lixiviating solution.
B lixiviating solution vacuum concentration to relative density is 1.08 ~ 1.12 (20 DEG C) by (), obtain mixed material extractum.
C (), by mixed material extractum spraying dry, obtains mixed material extract powder.
(4) capsule is prepared
Pulverize after being mixed homogeneously with mixed material extract powder by obtained Herba Dendrobii extract powder, cross 30 ~ 40 mesh sieves, particulate processed, granulate, finally carries out capsule fill and namely obtains compound dendrobium officinale capsule.
As preferably, in step (2), described compound enzyme is made up of cellulase, pectase and papain, and wherein the mass percentage of each enzyme is: 20 ~ 25% pectases, 5 ~ 10% papains, and surplus is cellulase.Main component dendrobium polysaccharide in Herba Dendrobii is often together with protein bound, exist with the form of proteoglycan, and the cell wall of Herba Dendrobii cell increase effective ingredient from cell to Extraction medium diffusion resistance to mass tranfer, above-mentioned two kinds of factors make the extraction time of Herba Dendrobii longer, the extraction ratio of extracting efficiency and effective ingredient is low, based on this, the present invention is by strict screening, select by cellulase, the compound enzyme of pectase and papain composition carries out enzymolysis to Herba Dendrobii, wherein papain can the effective protein that combines of enzymolysis and polysaccharide, polysaccharide is discharged and improves the yield of polysaccharide, reduce the content of protein in polysaccharide simultaneously, cellulase can abundant swelling cell wall, impels intracellular polysaccharide in abundant stripping, pectic substance between pectase energy degradation of cell, cell separation out, thus is conducive to cellulase and acts on Herba Dendrobii cell, improves extraction ratio, by the synergism of 3 kinds of enzymes, can by the constituent of cell wall hydrolysis or degraded, destroy the structure of cell wall, the effective ingredient of Herba Dendrobii is fully come out, dissolve, be suspended in solvent, thus reach the object improving extraction efficiency (alcohol extraction time shorten is 0.5 ~ 1h) and extraction ratio.
As preferably, step (4) is with step (b), and the technological parameter of vacuum concentration is: thickening temperature 60 ~ 70 DEG C, and vacuum is-0.08 ~-0.09MPa.
As preferably, step (5) is with step (c), and spray-dired technological parameter is: inlet temperature: 170 ~ 180 DEG C; Outlet temperature: 60 ~ 70 DEG C; Feed liquor speed: 40 ~ 45ml/min.
Therefore, the present invention has following beneficial effect:
(1) compound dendrobium officinale capsule of the present invention makes full use of the medicinal efficacy of Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati, take Herba Dendrobii as major ingredient, Fructus Lycii, Rhizoma Polygonati are that adjuvant is made, by the Synergistic of each raw material, there is the health-care effect such as enhancing immunity, alleviating physical fatigue, and taking convenience, easily absorb, there is huge market potential;
(2) provide a kind of compound dendrobium officinale capsule preparation method thereof, step is simple, low for equipment requirements, process stabilizing, and workable, production efficiency is high, is applicable to suitability for industrialized production;
(3) the present invention is by strict screening, selects the compound enzyme be made up of cellulase, pectase and papain to carry out enzymolysis to Herba Dendrobii, can improve extraction efficiency (alcohol extraction time shorten is 0.5 ~ 1h) and extraction ratio.
Detailed description of the invention
Below by detailed description of the invention, the present invention will be further described.
Embodiment 1
(1) prepare burden
By 400Kg Herba Dendrobii, 300Kg Fructus Lycii, the proportioning of 250Kg Rhizoma Polygonati takes Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati, stand-by.
(2) Herba Dendrobii extract powder is prepared
(1) Herba Dendrobii weighed up is cleaned, dries, pulverized, cross 60 mesh sieves and obtain dendrobium officinale powder;
(2) add water be incorporated as the compound enzyme of Herba Dendrobii quality 0.3% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, pH is regulated to be 5 after stirring, be warming up to 50 DEG C, after constant temperature enzymolysis 1h, be warming up to 90 DEG C of enzyme denaturing, cooling, compound enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 20% pectase, 5% papain, and surplus is cellulase.
(3) regulate pH be 8, then be incorporated as dendrobium officinale powder quality 8 times 75% alcoholic solution, be warming up to 75 DEG C of reflux, extract, 2 times, each 0.5 hour, merge alcohol extract, filter, reclaim ethanol, obtain extracting solution.
(4) be 1.08 (20 DEG C) by extracting solution vacuum concentration to relative density, obtain Herba Dendrobii extractum, the technological parameter of vacuum concentration is: thickening temperature 60 DEG C, and vacuum is-0.08MPa.
(5) by Herba Dendrobii extractum spraying dry, obtain Herba Dendrobii extract powder, spray-dired technological parameter is: inlet temperature: 170 DEG C; Outlet temperature: 60 DEG C; Feed liquor speed: 40ml/min.
(3) mixed material extract powder is prepared
A (), by after Fructus Lycii and Rhizoma Polygonati co-grinding, is incorporated as the water of Fructus Lycii and Rhizoma Polygonati gross mass 10 times, be heated to 100 DEG C of lixiviates 2 times, and each lixiviate 1h, filters and collect filtrate, obtaining lixiviating solution.
B lixiviating solution vacuum concentration to relative density is 1.08 (20 DEG C) by (), obtain mixed material extractum, the technological parameter of vacuum concentration is: thickening temperature 60 DEG C, and vacuum is-0.08MPa.
C (), by mixed material extractum spraying dry, obtains mixed material extract powder, spray-dired technological parameter is: inlet temperature: 170 DEG C; Outlet temperature: 60 DEG C; Feed liquor speed: 40ml/min.
(4) capsule is prepared
Pulverize after being mixed homogeneously with mixed material extract powder by obtained Herba Dendrobii extract powder, cross 30 mesh sieves, particulate processed, granulate, finally carries out capsule fill and namely obtains compound dendrobium officinale capsule.
Embodiment 2
(1) prepare burden
Press 450Kg Herba Dendrobii, 350Kg Fructus Lycii, the proportioning of 300Kg Rhizoma Polygonati takes Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati, stand-by.
(2) Herba Dendrobii extract powder is prepared
(1) Herba Dendrobii weighed up is cleaned, dries, pulverized, cross 80 mesh sieves and obtain dendrobium officinale powder;
(2) add water be incorporated as the compound enzyme of Herba Dendrobii quality 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, pH is regulated to be 6 after stirring, be warming up to 60 DEG C, after constant temperature enzymolysis 2h, be warming up to 95 DEG C of enzyme denaturing, cooling, compound enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 25% pectase, 10% papain, and surplus is cellulase.
(3) regulate pH be 9, then be incorporated as dendrobium officinale powder quality 12 times 80% alcoholic solution, be warming up to 80 DEG C of reflux, extract, 2 times, each 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extracting solution.
(4) be 1.12 (20 DEG C) by extracting solution vacuum concentration to relative density, obtain Herba Dendrobii extractum, the technological parameter of vacuum concentration is: thickening temperature 70 DEG C, and vacuum is-0.09MPa.
(5) by Herba Dendrobii extractum spraying dry, obtain Herba Dendrobii extract powder, spray-dired technological parameter is: inlet temperature: 180 DEG C; Outlet temperature: 70 DEG C; Feed liquor speed: 45ml/min.
(3) mixed material extract powder is prepared
A (), by after Fructus Lycii and Rhizoma Polygonati co-grinding, is incorporated as the water of Fructus Lycii and Rhizoma Polygonati gross mass 12 times, be heated to 100 DEG C of lixiviates 2 times, and each lixiviate 2h, filters and collect filtrate, obtaining lixiviating solution.
B lixiviating solution vacuum concentration to relative density is 1.12 (20 DEG C) by (), obtain mixed material extractum, the technological parameter of vacuum concentration is: thickening temperature 70 DEG C, and vacuum is-0.09MPa.
C (), by mixed material extractum spraying dry, obtains mixed material extract powder, spray-dired technological parameter is: inlet temperature: 180 DEG C; Outlet temperature: 70 DEG C; Feed liquor speed: 45ml/min.
(4) capsule is prepared
Pulverize after being mixed homogeneously with mixed material extract powder by obtained Herba Dendrobii extract powder, cross 40 mesh sieves, particulate processed, granulate, finally carries out capsule fill and namely obtains compound dendrobium officinale capsule.
Embodiment 3
(1) prepare burden
Press 430Kg Herba Dendrobii, 320Kg Fructus Lycii, the proportioning of 280Kg Rhizoma Polygonati takes Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati, stand-by.
(2) Herba Dendrobii extract powder is prepared
(1) Herba Dendrobii weighed up is cleaned, dries, pulverized, cross 70 mesh sieves and obtain dendrobium officinale powder;
(2) add water be incorporated as the compound enzyme of Herba Dendrobii quality 0.4% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, pH is regulated to be 5.5 after stirring, be warming up to 55 DEG C, after constant temperature enzymolysis 1.5h, be warming up to 92 DEG C of enzyme denaturing, cooling, compound enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 22% pectase, 6% papain, and surplus is cellulase.
(3) regulate pH be 8.5, then be incorporated as dendrobium officinale powder quality 10 times 78% alcoholic solution, be warming up to 76 DEG C of reflux, extract, 2 times, each 0.6 hour, merge alcohol extract, filter, reclaim ethanol, obtain extracting solution.
(4) be 1.1 (20 DEG C) by extracting solution vacuum concentration to relative density, obtain Herba Dendrobii extractum, the technological parameter of vacuum concentration is: thickening temperature 65 DEG C, and vacuum is-0.085MPa.
(5) by Herba Dendrobii extractum spraying dry, obtain Herba Dendrobii extract powder, spray-dired technological parameter is: inlet temperature: 175 DEG C; Outlet temperature: 65 DEG C; Feed liquor speed: 42ml/min.
(3) mixed material extract powder is prepared
A (), by after Fructus Lycii and Rhizoma Polygonati co-grinding, is incorporated as the water of Fructus Lycii and Rhizoma Polygonati gross mass 11 times, be heated to 100 DEG C of lixiviates 2 times, and each lixiviate 1.5h, filters and collect filtrate, obtaining lixiviating solution.
B lixiviating solution vacuum concentration to relative density is 1.1 (20 DEG C) by (), obtain mixed material extractum, the technological parameter of vacuum concentration is: thickening temperature 65 DEG C, and vacuum is-0.0859MPa.
C (), by mixed material extractum spraying dry, obtains mixed material extract powder, spray-dired technological parameter is: inlet temperature: 175 DEG C; Outlet temperature: 65 DEG C; Feed liquor speed: 42ml/min.
(4) capsule is prepared
Pulverize after being mixed homogeneously with mixed material extract powder by obtained Herba Dendrobii extract powder, cross 35 mesh sieves, particulate processed, granulate, finally carries out capsule fill and namely obtains compound dendrobium officinale capsule.
The quality index of the compound dendrobium officinale capsule that the present invention obtains is:
One. organoleptic indicator
| Project | Index |
| Color and luster | Pale brown or yellow |
| Tissue morphology | Fine particulate |
| Taste, abnormal smells from the patient | There is the distinctive fragranced of Herba Dendrobii |
| Impurity | Free from admixture |
Two. physical and chemical index
| Project | Index |
| Moisture/(%) | ≤6.0 |
| Ash/(%) | ≤6.0 |
| Disintegration/(min) | ≤30 |
| Arsenic (in As), (mg/kg) | ≤1.0 |
| Plumbous (in Pa), (mg/kg) | ≤1.5 |
| Tribute (in Hg), (mg/kg) | ≤0.3 |
| Gamma Hexaochlorocyclohexane/(mg/kg) | ≤0.2 |
| (clofenotane/(mg/kg) | ≤0.2 |
Three. microbiological indicator
Four. effective component index
| Project | Index |
| Crude polysaccharides (in glucosan)/(g/100g) | ≥7.74 |
Above-described embodiment is one of the present invention preferably scheme, not does any pro forma restriction to the present invention, also has other variant and remodeling under the prerequisite not exceeding the technical scheme described in claim.
Claims (5)
1. a compound dendrobium officinale capsule, is characterized in that, is made up of the raw material of following weight portion: 40 ~ 45 parts of Herba Dendrobii, 30 ~ 35 portions of Fructus Lyciis, 25 ~ 30 parts of Rhizoma Polygonatis.
2. a compound dendrobium officinale capsule preparation method thereof as claimed in claim 1, is characterized in that, comprise the following steps:
(1) prepare burden
Herba Dendrobii, Fructus Lycii and Rhizoma Polygonati is taken by above-mentioned weight, stand-by;
(2) Herba Dendrobii extract powder is prepared
(1) Herba Dendrobii weighed up is cleaned, dries, pulverized, cross 60 ~ 80 mesh sieves and obtain dendrobium officinale powder;
(2) add water be incorporated as the compound enzyme of Herba Dendrobii quality 0.3 ~ 0.5% in dendrobium officinale powder after, the addition of water is as the criterion with just submergence dendrobium officinale powder, regulates pH to be 5 ~ 6, be warming up to 50 ~ 60 DEG C after stirring, 90 ~ 95 DEG C of enzyme denaturing are warming up to, cooling after constant temperature enzymolysis 1 ~ 2h;
(3) regulate pH be 8 ~ 9, then be incorporated as dendrobium officinale powder quality 8 ~ 12 times 75 ~ 80% alcoholic solution, be warming up to 75 ~ 80 DEG C of reflux, extract, 2 times, each 0.5 ~ 1 hour, merge alcohol extract, filter, reclaim ethanol, obtain extracting solution;
(4) be 1.08 ~ 1.12 (20 DEG C) by extracting solution vacuum concentration to relative density, obtain Herba Dendrobii extractum;
(5) by Herba Dendrobii extractum spraying dry, Herba Dendrobii extract powder is obtained;
(3) mixed material extract powder is prepared
A (), by after Fructus Lycii and Rhizoma Polygonati co-grinding, is incorporated as the water of Fructus Lycii and Rhizoma Polygonati gross mass 10 ~ 12 times, be heated to 100 DEG C of lixiviates 2 times, and each lixiviate 1 ~ 2h, filters and collect filtrate, obtaining lixiviating solution;
B lixiviating solution vacuum concentration to relative density is 1.08 ~ 1.12 (20 DEG C) by (), obtain mixed material extractum;
C (), by mixed material extractum spraying dry, obtains mixed material extract powder;
(4) capsule is prepared
Pulverize after being mixed homogeneously with mixed material extract powder by obtained Herba Dendrobii extract powder, cross 30 ~ 40 mesh sieves, particulate processed, granulate, finally carries out capsule fill and namely obtains compound dendrobium officinale capsule.
3. compound dendrobium officinale capsule preparation method thereof according to claim 2, it is characterized in that, in step (2), described compound enzyme is made up of cellulase, pectase and papain, wherein the mass percentage of each enzyme is: 20 ~ 25% pectases, 5 ~ 10% papains, surplus is cellulase.
4. compound dendrobium officinale capsule preparation method thereof according to claim 2, is characterized in that, step (4) is with step (b), and the technological parameter of vacuum concentration is: thickening temperature 60 ~ 70 DEG C, and vacuum is-0.08 ~-0.09MPa.
5. compound dendrobium officinale capsule preparation method thereof according to claim 2, is characterized in that, step (5) is with step (c), and spray-dired technological parameter is: inlet temperature: 170 ~ 180 DEG C; Outlet temperature: 60 ~ 70 DEG C; Feed liquor speed: 40 ~ 45ml/min.
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| CN109198639A (en) * | 2018-09-26 | 2019-01-15 | 湖北省医药工业研究院有限公司 | A kind of composition for immunological enhancement containing the lactobacillus and its preparation method and application |
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