CN112569273A - Antiviral heat-clearing fire-removing dandelion and forsythia suspensa composition and preparation method thereof - Google Patents
Antiviral heat-clearing fire-removing dandelion and forsythia suspensa composition and preparation method thereof Download PDFInfo
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Abstract
The invention provides an antiviral heat-clearing fire-removing dandelion and forsythia suspensa composition and a preparation method thereof, wherein the composition comprises the following raw materials in parts by weight: 10-25 parts of dandelion extract, 10-25 parts of balsam pear extract, 7-18 parts of lotus seed extract, 7-18 parts of forsythia extract, 8-20 parts of honeysuckle extract, 8-20 parts of platycodon root extract, 7-18 parts of isatis root extract, 7-18 parts of scutellaria extract, 8-20 parts of codonopsis pilosula extract, 0.02-0.05 part of vitamin C and 0.01-0.04 part of taurine. The dandelion and forsythia suspensa composition provided by the invention has good effects of resisting viruses, clearing away heat and toxic materials, clearing liver-fire, nourishing yin to reduce pathogenic fire, and is beneficial to increasing the heart contractility, improving the organism immunity, enhancing the cell membrane oxidation resistance, protecting cardiac muscle cells and other wide biological functions.
Description
Technical Field
The invention relates to the technical field of pharmaceutical compositions, in particular to an antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition and a preparation method thereof.
Background
Frequent excessive internal heat is the manifestation of metabolic disorder of the body, which is classified as excess fire and deficient fire, and the main cause of excessive fire: firstly, the living habits are irregular, the people always stay up, and the food is irregular, especially the people always eat greasy and spicy food, garbage food and the like, so that excessive internal heat is easily caused, and the excessive internal heat is mostly caused; secondly, excessive mental stress, unsmooth mood, lack of movement and the like can also cause excessive internal heat; thirdly, the body is unbalanced in yin and yang and the liver fire is exuberant due to stagnation of liver qi, so that the body has excessive internal heat, gum swelling and pain, mouth corner erosion, oral ulcer and other symptoms, and also excessive fire; and fourthly, the deficiency fire is caused by low body immunity, weak viscera and deficiency of essence and blood. Frequent excessive internal heat can easily cause viral infection, cold and respiratory diseases, and even lung inflammation. The herbal food materials which are frequently eaten and used for resisting virus, clearing heat and removing fire are important measures for preventing and treating virus infection and influenza and respiratory system diseases, and are necessary for clearing heat and removing fire and regulating the metabolic balance of organisms.
Chinese patent application publication No. CN103099995A discloses a heat-clearing and fire-clearing pharmaceutical composition and a preparation method thereof, wherein the raw material medicines comprise, by weight, 10-15 parts of aloe, 10-15 parts of loquat leaves, 20-25 parts of coix seeds, 10-20 parts of salvia miltiorrhiza, 5-15 parts of rhizoma alismatis, 5-15 parts of selfheal, 10-15 parts of kudzuvine roots, 10-15 parts of raw hawthorns and 3-5 parts of raw liquorice. The pharmaceutical composition has the effects of clearing heat and removing fire, and can obviously improve the symptoms of excessive internal heat such as mouth blister, oral ulcer, facial acne, dry stool and the like.
However, the pharmaceutical composition for clearing heat and purging fire disclosed in the above technical scheme has poor heat and toxic material clearing effect, and cannot achieve the purposes of nourishing yin to reduce pathogenic fire, and clearing liver to purge pathogenic fire.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides an antiviral heat-clearing fire-clearing dandelion and forsythia suspensa composition and a preparation method thereof.
In order to achieve the purpose, the invention is realized by the following technical scheme:
the composition comprises the following raw materials in parts by weight: 10-25 parts of dandelion extract, 10-25 parts of balsam pear extract, 7-18 parts of lotus seed extract, 7-18 parts of forsythia extract, 8-20 parts of honeysuckle extract, 8-20 parts of platycodon root extract, 7-18 parts of isatis root extract, 7-18 parts of scutellaria extract, 8-20 parts of codonopsis pilosula extract, 0.02-0.05 part of vitamin C and 0.01-0.04 part of taurine.
Preferably, the composition comprises the following raw materials in parts by weight: 15-20 parts of dandelion extract, 15-20 parts of balsam pear extract, 10-15 parts of lotus seed extract, 10-15 parts of forsythia extract, 10-15 parts of honeysuckle extract, 10-15 parts of platycodon root extract, 10-15 parts of isatis root extract, 10-15 parts of scutellaria root extract, 10-15 parts of codonopsis pilosula extract, 0.02 part of vitamin C and 0.01 part of taurine.
The preparation method of the codonopsis pilosula extract comprises the following steps:
s1: weighing 8-20 parts of codonopsis pilosula according to parts by weight, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
The preparation method of the dandelion and forsythia suspensa composition for resisting viruses, clearing heat and removing fire comprises the following steps:
(1) weighing 15-20 parts of dandelion, 15-20 parts of balsam pear, 10-15 parts of lotus seed, 10-15 parts of fructus forsythiae, 10-15 parts of honeysuckle, 10-15 parts of platycodon grandiflorum, 10-15 parts of isatis root and 10-15 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8 extracting with 70% ethanol for a period of time, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into the M maltodextrin (1: 0.2), and spray drying to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
Preferably, the extraction time in the step (2) is 2 h.
Preferably, the spray drying conditions in the step (3) are that the inlet air temperature is 165-175 ℃, the outlet air temperature is 80-90 ℃, and the pressure in the tower is-35 to-40 Pa.
Dandelion is called "herb queen", and the records in Chinese medicine dictionary contain dandelion sterol, choline, organic acid and inulin. The record of Dandelion in Ben Cao Yan Yi Bu Yi (supplement to the Yi) records that Dandelion has the effects of removing heat toxin, eliminating malignant tumor, tuberculosis, relieving food toxicity and eliminating stagnation and whitening. The record of "follow-up house dietary spectra" has the effects of clearing lung-heat, relieving cough, eliminating phlegm, resolving masses, eliminating carbuncle, nourishing yin, cooling blood, relaxing muscles and tendons, strengthening teeth, promoting lactation and replenishing essence ". The dandelion is a core medicinal material for clearing heat, reducing internal heat, resisting bacteria, viruses and tumors.
Honeysuckle flower is sweet and cold in nature and fragrant in smell. Is rich in luteolin, chlorogenic acid, saponin and other active ingredients, and has effects of clearing away heat and toxic materials, nourishing liver, improving eyesight, dredging meridian passage, lowering blood pressure, reducing cholesterol, resisting bacteria, and relieving inflammation. Can relieve sore throat, oral ulcer, conjunctival congestion, swelling and pain, thick and white tongue fur, and gingival swelling and pain. It is commonly used to treat sore throat and upper respiratory tract infection.
The bitter gourd has a very remarkable fire-reducing effect, is mainly rich in saponin, amino acids and flavonoid compounds, and has physiological activities of tonifying spleen, stimulating appetite, reducing blood sugar, resisting bacteria, resisting tumors and the like; the bitter food is a natural enemy of fire, and bitter food contains alkaloid bitter substances, and the bitter substances have the effects of clearing away heat and toxic materials, clearing away heart-fire, improving eyesight, relieving fatigue and reducing excess fire.
Fructus forsythiae contains abundant forsythin and forsythiaside, and is a common traditional Chinese medicinal material for clearing heat and removing toxicity. Has the effects of clearing away heat and toxic materials, dispersing pathogenic accumulation, relieving swelling, dispelling pathogenic wind and heat, and clearing away heart heat. Is often used to treat respiratory tract infections; the forsythia has better antiviral effect and particularly strong resistance to bacteria, and has obvious inhibition effect on escherichia coli, dysentery bacillus, typhoid bacillus and staphylococcus.
The lotus seeds are neutral in nature, sweet and slightly astringent in taste, enter spleen and kidney heart channels, contain rich protein, carbohydrate, vitamin, calcium, iron, zinc and other trace elements, contain a plurality of water-soluble polysaccharides containing flavonoid substances, alkaloid, superoxide dismutase and other components, belong to edible and medicinal food materials, have high edible and medicinal values, and have the efficacy and effect on human bodies when the lotus seeds are eaten: the lotus seeds can clear heat and reduce pathogenic fire, especially for people with vigorous heart fire, eating the lotus seeds can effectively reduce heart fire, and has good conditioning effect on mouth and tongue sores caused by excessive internal heat; the lotus seeds contain a lot of vitamins and trace elements, have good effects of adjusting emotion and relaxing emotion, and can effectively calm nerves, promote sleep and improve sleep quality after being frequently eaten; the lotus seed has a large amount of trace elements, especially potassium element, and can reduce blood pressure. The potassium ions can effectively maintain the functions of the heart, participate in vivo metabolism, reduce the risk of stroke of middle-aged and elderly people, expand peripheral blood vessels and effectively help to reduce blood pressure; also has anticancer and cancer preventing effects.
The isatis root contains organic acids, alkaloids, sterols, anthraquinones and other compounds, has the functions of resisting virus, clearing away heat and toxic materials, cooling blood and relieving sore throat, is suitable for treating wind-heat type cold, influenza and other hot cold, is usually used together with honeysuckle flower and weeping forsythia and can also be used for treating erysipelas, sore throat and the like caused by internal heat toxin and fire heat attack. The isatis root has good antibacterial and antiviral effects, has inhibition effect on various bacteria, has better infection inhibition and proliferation inhibition effects on hepatitis B virus and various influenza viruses, and plays an important role in the period of eliminating SARS virus and influenza A virus.
The scutellaria baicalensis contains rich active substances such as baicalin, baicalein, flavone, trace elements and the like, and is a traditional Chinese medicine for clearing heat, removing toxicity, clearing heat and drying dampness. Has the main functions of clearing away lung heat and toxic material, and treating some diseases of upper respiratory tract with heat-toxin syndrome, such as swollen sore throat, dry throat and the like. Also has antibacterial and antiviral effects, and has strong inhibitory effect on various influenza viruses.
Radix codonopsitis is a tonifying medicinal material, is rich in lobetyolin, atractyloide III, codonopsis pilosula polysaccharide and the like, is often used as a substitute of ginseng, and has the effects of tonifying middle-jiao and Qi, harmonizing stomach and promoting fluid production, and eliminating phlegm and stopping cough. Can be used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, and spontaneous perspiration. It is mainly used for weakness of spleen and stomach, tiredness, hypodynamia, lung deficiency and dryness-heat.
Vitamin C is structurally similar to glucose, and is a polyhydroxy compound in which two adjacent enol-type hydroxyl groups at the 2 nd and 3 rd positions in the molecule are easily dissociated to release H +, and thus has an acid property, which is also called ascorbic acid. Vitamin C is necessary for antibody and collagen formation, tissue repair (including certain redox actions), metabolism of phenylalanine, tyrosine and folic acid, utilization of iron and carbohydrate, synthesis of fat and protein, maintenance of immune function, hydroxylation of 5-hydroxytryptamine, blood vessel integrity maintenance, non-heme iron absorption promotion and the like, and simultaneously the vitamin C also has the effects of oxidation resistance, free radical resistance and tyrosinase inhibition, so that the effects of whitening and spot lightening are achieved.
Taurine is a sulfur-containing amino acid with a simple structure in an animal body, and has a chemical name of 2-aminoethanesulfonic acid. Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like.
The invention has the following beneficial effects:
(1) the dandelion extract contains dandelion sterol, choline, organic acid, inulin and other active ingredients, and has the effects of clearing lung-heat, relieving cough and reducing sputum, eliminating stagnation and resolving carbuncle, nourishing yin and cooling blood, relaxing muscles and tendons and strengthening teeth, promoting lactation and replenishing vital essence; the honeysuckle has the effects of clearing away heat and toxic materials, nourishing the liver to improve eyesight, clearing and activating the channels and collaterals, reducing blood pressure and cholesterol, resisting bacteria and diminishing inflammation and the like, and the dandelion and the honeysuckle act in a matching way to prepare the composition, so that the effects of clearing away the lung-heat, eliminating stagnation and reducing swelling, clearing away heat and toxic materials, clearing and activating the channels and collaterals, resisting bacteria and diminishing inflammation and the like of the composition are improved.
(2) Fructus forsythiae contains abundant forsythin and forsythiaside, is a common traditional Chinese medicinal material for clearing heat and removing toxicity, has good antiviral effect, particularly strong resistance to bacteria, and has remarkable inhibition effect on escherichia coli, dysentery bacillus, typhoid bacillus and staphylococcus. The bitter gourd has a very remarkable fire-reducing effect, is mainly rich in saponin, amino acids and flavonoid compounds, and has physiological activities of tonifying spleen, stimulating appetite, reducing blood sugar, resisting bacteria, resisting tumors and the like.
(3) The lotus seeds contain rich proteins, carbohydrates, vitamins, calcium, iron, zinc and other trace elements, a plurality of water-soluble polysaccharides containing flavonoid substances, alkaloid, superoxide dismutase and other components, and have the effects of clearing heat and reducing internal heat.
(4) Radix Codonopsis is tonifying medicinal material, is rich in lobetyolin, atractyloide III, radix Codonopsis polysaccharide, etc., and can be used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, and spontaneous perspiration. It is mainly used for weakness of spleen and stomach, tiredness, hypodynamia, lung deficiency and dryness-heat. Taurine is an active substance for regulating normal physiological activities of organisms, and has a wide range of biological functions of diminishing inflammation, easing pain, maintaining the osmotic pressure balance of the organisms, maintaining the normal visual function, regulating the calcium balance of cells, reducing blood sugar, regulating nerve conduction, participating in endocrine activities, regulating lipid digestion and absorption, increasing the heart contractility, improving the immunity of the organisms, enhancing the oxidation resistance of cell membranes, protecting cardiac muscle cells and the like.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the composition comprises the following raw materials in parts by weight: 10 parts of dandelion extract, 25 parts of balsam pear extract, 7 parts of lotus seed extract, 18 parts of forsythia extract, 8 parts of honeysuckle extract, 20 parts of platycodon root extract, 7 parts of isatis root extract, 18 parts of scutellaria root extract, 8 parts of codonopsis pilosula extract, 0.05 part of vitamin C and 0.01 part of taurine.
The preparation method of the codonopsis pilosula extract comprises the following steps:
s1: weighing 8 parts of codonopsis pilosula according to parts by weight, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
A preparation method of an antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition comprises the following steps:
(1) weighing 10 parts of dandelion, 25 parts of balsam pear, 7 parts of lotus seed, 18 parts of fructus forsythiae, 8 parts of honeysuckle, 20 parts of platycodon grandiflorum, 7 parts of radix isatidis and 18 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8, adding 70% ethanol, extracting for 2h, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into M maltodextrin (1: 0.2), and spray drying at air inlet temperature of 165 deg.C, air outlet temperature of 90 deg.C and tower pressure of-35 Pa to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
Example 2:
the composition comprises the following raw materials in parts by weight: 25 parts of dandelion extract, 10 parts of balsam pear extract, 18 parts of lotus seed extract, 7 parts of forsythia extract, 20 parts of honeysuckle extract, 8 parts of platycodon root extract, 18 parts of isatis root extract, 7 parts of scutellaria root extract, 20 parts of codonopsis pilosula extract, 0.02 part of vitamin C and 0.04 part of taurine.
The preparation method of the codonopsis pilosula extract comprises the following steps:
s1: weighing 20 parts of codonopsis pilosula according to the weight parts, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
A preparation method of an antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition comprises the following steps:
(1) weighing 25 parts of dandelion, 10 parts of balsam pear, 18 parts of lotus seed, 7 parts of forsythia, 20 parts of honeysuckle, 8 parts of platycodon grandiflorum, 18 parts of isatis root and 7 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8, adding 70% ethanol, extracting for 2h, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into M maltodextrin (1: 0.2), and spray drying at air inlet temperature of 175 deg.C, air outlet temperature of 80 deg.C and tower pressure of-40 Pa to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
Example 3:
the composition comprises the following raw materials in parts by weight: 15 parts of dandelion extract, 15 parts of balsam pear extract, 15 parts of lotus seed extract, 15 parts of forsythia extract, 10 parts of honeysuckle extract, 10 parts of platycodon root extract, 15 parts of isatis root extract, 15 parts of scutellaria root extract, 10 parts of codonopsis pilosula extract, 0.02 part of vitamin C and 0.01 part of taurine.
The preparation method of the codonopsis pilosula extract comprises the following steps:
s1: weighing 10 parts of codonopsis pilosula according to the weight parts, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
A preparation method of an antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition comprises the following steps:
(1) weighing 15 parts of dandelion, 15 parts of balsam pear, 15 parts of lotus seed, 15 parts of forsythia, 10 parts of honeysuckle, 10 parts of platycodon root, 15 parts of isatis root and 15 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8, adding 70% ethanol, extracting for 2h, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into M maltodextrin (1: 0.2), and spray drying at air inlet temperature of 170 deg.C, air outlet temperature of 85 deg.C and tower pressure of-37 Pa to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
Example 4:
the composition comprises the following raw materials in parts by weight: 20 parts of dandelion extract, 20 parts of balsam pear extract, 10 parts of lotus seed extract, 10 parts of forsythia extract, 15 parts of honeysuckle extract, 15 parts of platycodon root extract, 10 parts of isatis root extract, 10 parts of scutellaria extract, 15 parts of codonopsis pilosula extract, 0.02 part of vitamin C and 0.01 part of taurine.
The preparation method of the codonopsis pilosula extract comprises the following steps:
s1: weighing 15 parts of codonopsis pilosula according to parts by weight, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
A preparation method of an antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition comprises the following steps:
(1) weighing 20 parts of dandelion, 20 parts of balsam pear, 10 parts of lotus seed, 10 parts of fructus forsythiae, 15 parts of honeysuckle, 15 parts of platycodon grandiflorum, 10 parts of radix isatidis and 10 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8, adding 70% ethanol, extracting for 2h, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into M maltodextrin (1: 0.2), and spray drying at air inlet temperature of 175 deg.C, air outlet temperature of 80 deg.C and tower pressure of-40 Pa to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
Typical cases
One, Liu somebody, male, 17 years old, continuously eat 3 days of roast meat, cause sore throat, inflammation of tonsil, already cause low fever, take the dandelion and forsythia composition obtained in example 1 after 2 times a day, 3-5 g each time, drink tea soup after boiling water, do not eat western medicine, do not make an injection, get better after 2 days, fully recover in 4 days.
And secondly, Pengzhi, male and 20 years old are in need of sitting in front of a computer for a long time due to work, eyes are dry and tired, sweating due to debility often occurs, the dandelion and fructus forsythiae composition obtained in example 2 is taken later, 2 times a day and 3-5 g each time, tea soup is drunk after boiling water, the tea soup is improved after 2 days, and the tea soup is cured after 5 days.
And thirdly, when a woman is in the age of 31 years and has a few whelks growing on the face due to constipation, the dandelion and forsythia suspensa composition obtained in the example 3 is taken 2 times a day, 3-5 g of the dandelion and forsythia suspensa composition is taken every time, tea soup is drunk after the tea is soaked with boiled water, the tea soup is improved after 2 days, and the beautiful appearance is recovered after 3 days.
And fourthly, aging a certain part of the old, female, age 33, dry cough in throat, high body feeling temperature and frequent sweating, taking the dandelion and forsythia suspensa composition obtained in example 4 2 times a day, 3-5 g each time, soaking in boiled water, drinking tea soup, getting better after 3 days, and recovering after 5 days.
Fifthly, a certain season, female, 34 years old, dry cough with throat, higher body feeling temperature and frequent sweating, the medicinal composition obtained by the prior art (CN103099995A) is taken 2 times a day, 3-5 g each time, the tea is drunk after being soaked in boiling water, no obvious improvement is realized after 5 days, improvement is realized after 7 days, hyperhidrosis is still realized, and the recovery is realized after 10 days.
As can be seen from the above typical cases, the dandelion and forsythia suspensa compositions provided in embodiments 1 to 4 of the present invention have a good curative effect on patients with high body temperature and frequent sweating, compared to the pharmaceutical composition obtained in the prior art (CN103099995A), and the dandelion and forsythia suspensa compositions obtained in the present invention have excellent effects of clearing heat, removing toxicity, nourishing yin, decreasing pathogenic fire, clearing liver, and purging pathogenic fire.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (6)
1. The composition is characterized by comprising the following raw materials in parts by weight: 10-25 parts of dandelion extract, 10-25 parts of balsam pear extract, 7-18 parts of lotus seed extract, 7-18 parts of forsythia extract, 8-20 parts of honeysuckle extract, 8-20 parts of platycodon root extract, 7-18 parts of isatis root extract, 7-18 parts of scutellaria extract, 8-20 parts of codonopsis pilosula extract, 0.02-0.05 part of vitamin C and 0.01-0.04 part of taurine.
2. The antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition according to claim 1, which comprises the following raw materials in parts by weight: 15-20 parts of dandelion extract, 15-20 parts of balsam pear extract, 10-15 parts of lotus seed extract, 10-15 parts of forsythia extract, 10-15 parts of honeysuckle extract, 10-15 parts of platycodon root extract, 10-15 parts of isatis root extract, 10-15 parts of scutellaria root extract, 10-15 parts of codonopsis pilosula extract, 0.02 part of vitamin C and 0.01 part of taurine.
3. The antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition according to claim 1, wherein the preparation method of the codonopsis pilosula extract comprises:
s1: weighing 8-20 parts of codonopsis pilosula according to parts by weight, cleaning, drying at 60 ℃, and crushing into 20-mesh coarse powder for later use;
s2: adding water into the coarse powder in the S1 for extraction twice, wherein the mass ratio of the first coarse powder to the second coarse powder is M: adding water in a ratio of M water to 10, extracting for 2 hours under reflux, and taking primary filtrate; filtering residues for the second time according to the mass ratio M: adding water in a ratio of M water to 8: 1, extracting for 1.5h under reflux, taking secondary filtrate, and combining the two filtrates;
s3: concentrating the extracting solution obtained in the step S2 under reduced pressure to obtain an extract with the specific gravity d of 1.20, standing and cooling, wherein the extract is prepared according to the following steps of: m ethanol ═ 1:8, adding 80% ethanol, stirring, standing overnight, centrifuging to obtain precipitate, adding 2 times of 80% ethanol to the precipitate, washing, and drying under reduced pressure to obtain radix Codonopsis extract.
4. A method for preparing the antiviral, heat-clearing and fire-clearing dandelion and forsythia suspensa composition according to any one of claims 1 to 3, characterized in that the preparation method comprises the following steps:
(1) weighing 15-20 parts of dandelion, 15-20 parts of balsam pear, 10-15 parts of lotus seed, 10-15 parts of fructus forsythiae, 10-15 parts of honeysuckle, 10-15 parts of platycodon grandiflorum, 10-15 parts of isatis root and 10-15 parts of scutellaria baicalensis according to parts by weight, cleaning, drying at 80 ℃, crushing into 20-mesh coarse powder, and uniformly mixing for later use;
(2) mixing the mixture coarse powder obtained in the step (1) into M mixture coarse powder in a weight ratio: m ethanol ═ 1:8 extracting with 70% ethanol for a period of time, filtering to obtain ethanol extract, concentrating under reduced pressure, recovering ethanol, and spray drying to obtain ethanol extract;
(3) taking the filter residue obtained in the step (2), adding 10 times of water by mass, carrying out hot reflux extraction for 2 times, 1.5h each time, combining the two extracting solutions, and concentrating under reduced pressure until the specific gravity d is 1.05-1.10, wherein the weight ratio of M raw materials is as follows: adding maltodextrin into the M maltodextrin (1: 0.2), and spray drying to obtain water extract powder;
(4) pulverizing the ethanol extract to 100 mesh, and mixing with the water extract powder to obtain mixed extract of herba Taraxaci, fructus forsythiae, etc.;
(5) weighing the rest raw materials according to the formula proportion, uniformly mixing the rest raw materials with the mixed extracts of the codonopsis pilosula extract, the dandelion, the forsythia and the like, and granulating to obtain the finished product.
5. The method for preparing the dandelion and forsythia composition for resisting virus, clearing heat and removing fire according to claim 4, wherein the extraction time in the step (2) is 2 hours.
6. The method for preparing the dandelion and forsythia composition for resisting virus, clearing heat and reducing fire according to claim 4, wherein the spray drying conditions in the step (3) are that the air inlet temperature is 165-175 ℃, the air outlet temperature is 80-90 ℃, and the pressure in the tower is-35 to-40 Pa.
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| CN114425074A (en) * | 2021-11-26 | 2022-05-03 | 国众兴合生物医药科技有限公司 | Natural compound oral liquid with antiviral and immunity enhancing effects and preparation method thereof |
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| CN103907725A (en) * | 2014-03-24 | 2014-07-09 | 贵港市港北区鑫农桑蚕种养专业合作社 | Heat-clearing and toxin-removing mulberry leaf tea |
| CN106720702A (en) * | 2016-12-22 | 2017-05-31 | 广州肇基生物科技有限公司 | A kind of clearing heat and cooling blood tea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103907725A (en) * | 2014-03-24 | 2014-07-09 | 贵港市港北区鑫农桑蚕种养专业合作社 | Heat-clearing and toxin-removing mulberry leaf tea |
| CN106720702A (en) * | 2016-12-22 | 2017-05-31 | 广州肇基生物科技有限公司 | A kind of clearing heat and cooling blood tea and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114425074A (en) * | 2021-11-26 | 2022-05-03 | 国众兴合生物医药科技有限公司 | Natural compound oral liquid with antiviral and immunity enhancing effects and preparation method thereof |
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