CN104856968A - Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof - Google Patents
Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof Download PDFInfo
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals. The traditional Chinese medicine tablet comprises the following raw materials in parts by weight: 400-450 parts of astragalus membranaceus, 250-300 parts of ligusticum wallichii, 200-250 parts of root of red-rooted salvia, 130-160 parts of pseudo-ginseng, 130-160 parts of rhizoma alismatis, 130-160 parts of cassia twigs, 130-160 parts of radix curcumae, 130-160 parts of hawthorn, 60-90 parts of sophora flower, 60-90 parts of elecampane and 5-8 parts of borneol. The invention further provides a preparation method of the traditional Chinese medicine tablet. The preparation method is simpler and more reasonable, and the contents of active ingredients in the prepared traditional Chinese medicine tablet are higher.
Description
Technical field
The present invention relates to the pharmaceutical formulation of field of medicaments, specifically a kind of have Chinese medicinal tablet of eliminating thrombus and removing obstruction in channels effect and preparation method thereof.
Background technology
XIAOSHUAN TONGLUO PIAN is that Chinese Pharmacopoeia records kind.Be prepared from by Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Notoginseng, Flos Sophorae, Ramulus Cinnamomi, Radix Curcumae, the Radix Aucklandiae, Borneolum Syntheticum, Fructus Crataegi, there is blood circulation promoting and blood stasis dispelling, the function of promoting the flow of QI in the collateral by warming the meridian.Be used for the treatment of that blood fat increases, apoplexy (cerebral thrombosis) convalescent period (in 1 year) hemiplegia clinically, the diseases such as numb limbs and tense tendons, hands and feet coolness, bradylalia are the Chinese medicine compound preparations of Cardiovarscular.
Apoplexy causes one of human death's three large diseases, is the first cause of due to illness disabling, and is also a main publilc health burden in world wide.Show apoplexy Li Shengli and studying for a long period of time of protective agents, this kind of disease risk factor is numerous, pathophysiological change is complicated, and a certain chemistry of application or biological preparation are difficult to receive good therapeutic effect separately.And with comprehensively regulating be feature Chinese medicine preparation---XIAOSHUAN TONGLUO PIAN is respond well in the treatment of such disease.But the technique of existing XIAOSHUAN TONGLUO PIAN is continue to use the method for traditional decoction substantially, the crude drug soak by water beyond Radix Notoginseng, Borneolum Syntheticum extracts for 3 times.The method is low to effective component extraction rate, also inevitably proposes a large amount of water-solubility impurity.The content of the amount of the effect that traditional Chinese medicine disease prevention is cured the disease and extract and wherein effective ingredient has direct relation.If extraction process is unreasonable, not science, destruction and the loss of effective ingredient certainly will be caused, thus affect quality, the curative effect of preparation.In addition, the disintegration time of existing XIAOSHUAN TONGLUO PIAN is longer, and after long-term especially placement, have the phenomenon exceeding standards of pharmacopoeia, the long meeting of disintegration time has a strong impact on the absorption of medicine.
Along with system is clinically to drug quality, the improving constantly and the development of pharmaceutical technology of effect requirements, this technique can not meet current demand, be badly in need of the preparation that a kind of extracts active ingredients is more complete, content is higher, to play the medical value of the classical prescription of eliminating thrombus and removing obstruction in channels better.
Summary of the invention
The object of the invention is for the deficiencies in the prior art, the XIAOSHUAN TONGLUO PIAN that a kind of extracts active ingredients is more complete, content is higher is provided, thus plays the medical value of this traditional proved recipe better.
The invention provides a kind of Chinese medicinal tablet with eliminating thrombus and removing obstruction in channels effect, the raw material of this Chinese medicinal tablet is: the Radix Astragali 400 ~ 450 weight portion, Rhizoma Chuanxiong 250 ~ 300 weight portion, Radix Salviae Miltiorrhizae 200 ~ 250 weight portion, Radix Notoginseng 130 ~ 160 weight portion, Rhizoma Alismatis 130 ~ 160 weight portion, Ramulus Cinnamomi 130 ~ 160 weight portion, Radix Curcumae 130 ~ 160 weight portion, Fructus Crataegi 130 ~ 160 weight portion, Flos Sophorae 60 ~ 90 weight portion, the Radix Aucklandiae 60 ~ 90 amount part, Borneolum Syntheticum 5 ~ 8 weight portion;
This Chinese medicinal tablet is obtained by following preparation method:
(1) get the raw material outside above-mentioned Radix Notoginseng, Borneolum Syntheticum, add the warm water (distilled water) of 3 ~ 5 times amount and the compound enzyme of 3 ~ 5% (with medical material weighing scales), mixing, 45 ~ 55 DEG C are incubated enzymolysis 1 ~ 2 hour; Extract 2 times with steam distillation after adding water, collect volatile oil, add ethanol hold over night after concentrating filtrate merging, filter, filtrate recycling ethanol, concentrated, obtain extractum, extractum density 1.1 ~ 1.15 (50 DEG C); Described compound enzyme is the mixture of cellulase and pectase;
(2) Radix Notoginseng, Borneolum Syntheticum are pulverized respectively;
(3) the extractum that (2) step obtains is mixed with Radix Notoginseng powder, granulate, dry;
(4) to step (3) gained spraying particles volatile oil, add Borneolum Syntheticum powder and magnesium stearate, mixing, tabletting, film coating, to obtain final product.
The consumption of above-mentioned magnesium stearate is 1% (w/w), that is, magnesium stearate account for total tablet heavy 1%.
Rhizoma Chuanxiong in crude drug, Radix Curcumae, Ramulus Cinnamomi and the Radix Aucklandiae all contain a large amount of volatile effective component, and the method for the direct water extraction of existing technique certainly will cause the waste of this fractions.
Constantly there is the application of people's studying enzyme in Chinese medicine extraction in recent years, and achieve good effect.The present invention adopts this advanced technology, and the character feature according to each crude drug effective ingredient is optimized traditional decoction technique and improves.Lot of experiments has been done in selection for enzyme class and consumption.Finally obtain the tablet that above-mentioned preparation method and this method are obtained.The method has carried out purification to extract, when decreasing a large amount of impurity, extract (dry extract) yield obtained is suitable with existing method, the more important thing is, astragaloside wherein and the content of rutin all have and improved in various degree, that is, improve the content of effective ingredient in preparation, and then improve its curative effect.
For reducing the invalid components amount taken, the present invention introduces the step of precipitate with ethanol, to remove the water-solubility impurities such as destarching.Inventor investigates for the concentrated density of extracting solution in precipitate with ethanol step and determining alcohol, thus take into account in precipitate with ethanol process the alcohol amount that consumes, factor such as the recovery time of ethanol, the loss of effective ingredient etc., finally, determining that extracting solution is concentrated into density is 1:(1 ~ 2) ml/g is (namely, every 1 ~ 2g crude drug is concentrated into 1ml), adding ethanol extremely pure and strong is 50 ~ 60% (v/v).
Current extraction process is soak by water three times, and only this link spent time is just 7 ~ 9 hours (containing the intermediate link time), water consumption 22 ~ 24 times amount.Because this medicine is long-term prescription, and medication crowd is huge, so long-term production institute's power consumption and the water yield are surprising.The present invention not only increases the efficiency of extraction through the method for making optimized, and also a saving mass energy, is also making full use of Chinese crude drug increasingly in short supply simultaneously.
The raw material of preparation 500 Chinese medicinal tablets of the present invention is: Radix Astragali 428-435g, Rhizoma Chuanxiong 285-290g, Radix Salviae Miltiorrhizae 210-220g, Radix Notoginseng 140-150g, Rhizoma Alismatis 140-150g, Ramulus Cinnamomi 140-150g, Radix Curcumae 140-150g, Fructus Crataegi 140-150g, Flos Sophorae 70-75g, Radix Aucklandiae 70-75g, Borneolum Syntheticum 5.5-6.0g; The Unit Weight of this Chinese medicinal tablet that described method obtains is 0.76g/ sheet.
The raw material of preparation 500 these Chinese medicinal tablets is preferably: Radix Astragali 431g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Notoginseng 144g, Rhizoma Alismatis 144g, Ramulus Cinnamomi 144g, Radix Curcumae 144g, Fructus Crataegi 144g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; The unit dose of this Chinese medicinal tablet is 0.76g/ sheet, that is, the specification of this Chinese medicinal tablet (general " XIAOSHUAN TONGLUO PIAN " by name) is 0.76g/ sheet.
Above-mentioned compound enzyme is cellulase and the pectase of 3:1.Containing natural cellulase inhibitor in plant tissue; It can exempt from the decomposition of mycete by protective plant, therefore, different vegetable drugs or combination, the enzyme that is suitable for and consumption be not quite similar.The weak effect of enzymolysis when the consumption of enzyme is on the low side, along with the concentration of enzyme raises, increases with the contact area of substrate, and enzyme digestion reaction speed increases, but not more high better, and then can produce inhibitory action when enzyme reaches a certain concentration, enzyme is not fully utilized, and causes waste.Therefore, inventor investigates the kind of enzyme and consumption, finds that difference on effect is obvious.Wherein with the compound enzyme best results of cellulase, pectase 3:1 ratio combination, significantly improve the rate of transform of astragaloside, up to 95.5%, comparatively water extraction method promotes 19%.
In addition, hydrolysis temperature and enzymolysis time also have considerable influence to hydrolysis result.Screening experiment result shows, optimum enzymolysis condition is: 50 DEG C, 1 hour.
Under the effect of enzyme, not only increase extraction effect, also considerably reduce time and the number of times of water extraction.The extracting method (1) of step described in this is specially: 8 ~ 10 times amount water extraction 1 hour first, second time 6 ~ 8 times of water gagings 0.5 hour.
(1) described step is further: extract filtrate and be concentrated into 1:(1 ~ 2) ml/g, slowly adding ethanol to determining alcohol under stirring is 50% (v/v), leaves standstill 12 ~ 18 hours.
(3) described step is Radix Notoginseng powder and disintegrating agent are mixed, and is added to soft material processed in the extractum of step (2) gained, granulates, dry.Wherein, described disintegrating agent is polyvinylpolypyrrolidone and/or cross-linking sodium carboxymethyl cellulose.In a preferred embodiment, polyvinylpolypyrrolidone and the cross-linking sodium carboxymethyl cellulose of described disintegrating agent to be amount ratio be 2:1, consumption is 2 ~ 5% (w/w), preferably 2%.
Take Chinese medicine extract as the tablet of key component, because extract component is many and complicated oneself viscosity is higher, general disintegration time is all partially long, particularly long-term place after, the trend that disintegration time continues to extend is obvious.Therefore, the present invention with the addition of appropriate disintegrating agent, and tablet disintegration times made after adding disintegrating agent, at about 15 minutes, accelerates placement also complete disintegrate at about 22 minutes after 6 months.Effectively prevent disintegrate and cross the slow adverse effect that curative effect is caused.
The preparation method of Chinese medicinal tablet of the present invention by extract extractum directly and the mixing granulation such as Radix Notoginseng powder, decreases the step of this extracting section thing drying and crushing, simplifies processing step, improve production efficiency.
Inventor by following experiment investigation different process step and parameter on the impact of Chinese medicinal tablet of the present invention.
Reiterate: following test is the illustrative test in development process of the present invention in numerous test, do not contained with limit all experiments that invention people does for the present invention, object is only partial routine and the result of setting forth Chinese medicinal tablet preparation method screening and optimizing of the present invention by those data.
One, the screening experiment of enzyme class and consumption
1, test sample: take the Radix Astragali, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Ramulus Cinnamomi, Radix Curcumae, Fructus Crataegi, Flos Sophorae and the Radix Aucklandiae according to the preferred feedstock proportioning of above-mentioned Chinese medicinal tablet, be ground into coarse granule, mixing, takes mixed material medicine 50g/ part, totally 30 parts.
2, experimental technique: with direct water boiling and extraction method for contrast, more several enzyme and different amounts are on the impact of crude drug effective component extracting of the present invention.
Wherein, decocting cooking method is: soak by water 1 time, 10 times amount soak by water 2 hours, and filtrate, measures and calculate the astragaloside rate of transform.
Enzymatic isolation method: add 4 times amount warm water in mixed material medicine, is added to the water according to enzyme class and consumption in table 1, mixing, and 45 DEG C are incubated 1.5 hours, and moisturizing to 8 times amount, extracts 1 hour with steam distillation, filtrate, measures and calculates the astragaloside rate of transform.
Astragaloside is measured according to version " Chinese Pharmacopoeia " Milkvetch Root assay chromatographic condition in 2010.
Sample treatment:
After extracting liquid filtering, precision measures 2ml respectively, puts 50ml and holds in bottle, add methanol to scale, filter, to obtain final product with microporous filter membrane (0.45 μm).Configuration astragaloside reference substance solution is about 60ug/ml.
3, experimental result: experimental data shows, extract after enzymolysis, the rate of transform of astragaloside obviously promotes again, and obvious difference between different enzyme, the compound enzyme effect wherein coordinated in 3:1 ratio with cellulase and pectase is the most remarkable, and the rate of transform of astragaloside improves 19%; The trend that the consumption of different enzyme affects the astragaloside rate of transform is different, e.g., almost do not affect, and cellulase consumption 4% enzymolysis efficiency is the highest between neutral protease different amounts.Refer to table 1.
The screening test result of table 1 enzyme class and consumption
Two, the investigation of hydrolysis temperature
1, test sample: with experiment one.
2, experimental technique: on the basis of experiment one enzymatic isolation method, with the cellulase of 3:1 and pectase for compound enzyme, investigates the impact of different hydrolysis temperature on the astragaloside rate of transform according to table 2 respectively.
3, experimental result: experimental data shows, hydrolysis temperature is between 35 DEG C to 50 DEG C, and the rate of transform raising astragaloside with temperature improves constantly, obvious to downward trend when 60 DEG C, therefore, between 45 DEG C to 55 DEG C, all has good hydrolysis result, wherein with 50 DEG C of the bests.Refer to table 2.
The investigation result of table 2 hydrolysis temperature
| Group number | Hydrolysis temperature | Astragaloside rate of transform % |
| 1 | 35℃ | 85.5 |
| 2 | 40℃ | 91.4 |
| 3 | 45℃ | 94.7 |
| 4 | 50℃ | 96.2 |
| 5 | 55℃ | 95.1 |
| 6 | 60℃ | 92.9 |
Three, the investigation of enzymolysis time
1, test sample: with experiment one.
2, experimental technique: on the basis of experiment one enzymatic isolation method, with the cellulase of 3:1 and pectase for compound enzyme, 50 DEG C is under hydrolysis temperature condition, investigates enzymolysis time on the impact of extracting.
3, experimental result: experimental data shows, under equal conditions, the rate of transform of the little time astragaloside of enzymolysis 1 ~ 2, without significant difference, for enhancing productivity, saves time, preferred enzymolysis 1 hour.Refer to table 3.
The investigation result of table 3 hydrolysis temperature
| Group number | Enzymolysis time | Astragaloside rate of transform % |
| 1 | 0.5 hour | 91.6 |
| 2 | 1 hour | 96.1 |
| 3 | 1.5 hour | 96.5 |
| 4 | 2 hours | 96.2 |
Four, the selection of disintegrating agent in tablet
The extractum that (1) step of the present invention obtains is mixed with Radix Notoginseng powder, adds the granulation of different disintegrating agent 2% (w/w), dry; To granule spray volatile oil, mix with Borneolum Syntheticum, add the rear tabletting of magnesium stearate mixing, film coating, detects disintegration according to official method.Result shows, polyvinylpolypyrrolidone and cross-linking sodium carboxymethyl cellulose all obviously can accelerate disintegration rate, and after particularly the two coordinates with 2:1 ratio, disintegration time significantly shortens.Refer to table 4.
The selection result of table 4 disintegrating agent
| Group number | Disintegrating agent | Disintegration time (min) |
| 1 | —— | 23.5 |
| 2 | Carboxymethyl starch sodium | 22.6 |
| 3 | Cross-linking sodium carboxymethyl cellulose | 19.1 |
| 4 | Low-substituted hydroxypropyl cellulose | 20.5 |
| 5 | Polyvinylpolypyrrolidone | 17.8 |
| 6 | Polyvinylpolypyrrolidone+cross-linking sodium carboxymethyl cellulose (1:1) | 17.2 |
| 7 | Polyvinylpolypyrrolidone+cross-linking sodium carboxymethyl cellulose (2:1) | 15.3 |
| 8 | Polyvinylpolypyrrolidone+cross-linking sodium carboxymethyl cellulose (1:2) | 19.4 |
Specific embodiments
Embodiment 1
500 tablet recipes:
Radix Astragali 431g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Notoginseng 144g, Rhizoma Alismatis 144g, Ramulus Cinnamomi 144g, Radix Curcumae 144g, Fructus Crataegi 144g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; Polyvinylpolypyrrolidone 5g, cross-linking sodium carboxymethyl cellulose 2.5g, magnesium stearate 3.8g.
Preparation method:
(1) get the above-mentioned raw materials outside Radix Notoginseng, Borneolum Syntheticum, add the warm water of 3 times amount and the compound enzyme (cellulase of 3:1 and pectase, lower same) of 4%, mixing, 50 DEG C are incubated enzymolysis 1 hour; Add distilled water to 8 times amount, steam distillation extracts 2 times, collects volatile oil, 1 hour first time, second time adds 6 times of water gagings 0.5 hour, collecting decoction, filter, add ethanol after filtrate reduced in volume to 1:1.5ml/g to determining alcohol 50%, leave standstill 12 hours, filter, filtrate recycling ethanol, concentrated, obtain extractum, extractum density 1.13 (50 DEG C);
(2) Radix Notoginseng, Borneolum Syntheticum are crushed to 100 orders respectively, for subsequent use;
(3) polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose and Radix Notoginseng powder are mixed, be added to soft material processed in the extractum of step (2) gained, granulate, dry;
(4) in step (3) gained granule, spray volatile oil, add Borneolum Syntheticum powder and magnesium stearate, mixing, tabletting, film coating, to obtain final product.The Unit Weight of this Chinese medicinal tablet that said method obtains is 0.76g/ sheet (namely specification is 0.76g/ sheet).
Embodiment 2
500 tablet recipes:
Radix Astragali 431g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Notoginseng 144g, Rhizoma Alismatis 144g, Ramulus Cinnamomi 144g, Radix Curcumae 144g, Fructus Crataegi 144g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; Polyvinylpolypyrrolidone 3.8g, cross-linking sodium carboxymethyl cellulose 3.8g, magnesium stearate 3.8g.
Preparation method difference from Example 1 is:
(1) get the above-mentioned raw materials outside Radix Notoginseng, Borneolum Syntheticum, add the warm water of 5 times amount and the compound enzyme of 3%, mixing, 45 DEG C are incubated enzymolysis 1.5 hours; Add distilled water to 10 times amount, steam distillation extracts 2 times, collects volatile oil, second time adds 6 times of water gagings, collecting decoction, filter, filtrate adds ethanol to determining alcohol 60% after being concentrated into 1:1ml/g, leave standstill 14 hours, filter, filtrate recycling ethanol, concentrated, obtain extractum, extractum density 1.1 (50 DEG C).
Embodiment 3
500 tablet recipes:
Radix Astragali 431g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Notoginseng 144g, Rhizoma Alismatis 144g, Ramulus Cinnamomi 144g, Radix Curcumae 144g, Fructus Crataegi 144g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; Polyvinylpolypyrrolidone 7.6g, magnesium stearate 3.8g.
Preparation method difference from Example 1 is:
(1) get the above-mentioned raw materials outside Radix Notoginseng, Borneolum Syntheticum, add the warm water of 4 times amount and the compound enzyme of 5%, mixing, 55 DEG C are incubated enzymolysis 2 hours; Add distilled water to 8 times amount, steam distillation extracts 2 times, collects volatile oil, second time adds 8 times of water gagings, collecting decoction, filter, filtrate adds ethanol to determining alcohol 55% after being concentrated into 1:2ml/g, leave standstill 18 hours, filter, filtrate recycling ethanol, concentrated, obtain extractum, extractum density 1.15 (50 DEG C).
Embodiment 4
500 tablet recipes:
Radix Astragali 400g, Rhizoma Chuanxiong 300g, Radix Salviae Miltiorrhizae 200g, Radix Notoginseng 160g, Rhizoma Alismatis 160g, Ramulus Cinnamomi 130g, Radix Curcumae 160g, Fructus Crataegi 130g, Flos Sophorae 60g, Radix Aucklandiae 90g, Borneolum Syntheticum 5g; Magnesium stearate 3.8g.
Preparation method is with either method in embodiment 1 ~ 3.
Embodiment 5
500 tablet recipes:
Radix Astragali 450g, Rhizoma Chuanxiong 250g, Radix Salviae Miltiorrhizae 250g, Radix Notoginseng 130g, Rhizoma Alismatis 130g, Ramulus Cinnamomi 160g, Radix Curcumae 130g, Fructus Crataegi 160g, Flos Sophorae 90g, Radix Aucklandiae 60g, Borneolum Syntheticum 8g; Cross-linking sodium carboxymethyl cellulose 7.6g, magnesium stearate 3.8g.
Preparation method is with either method in embodiment 1 ~ 3.
Embodiment 6
500 tablet recipes are:
Radix Astragali 428g, Rhizoma Chuanxiong 285g, Radix Salviae Miltiorrhizae 210g, Radix Notoginseng 140g, Rhizoma Alismatis 140g, Ramulus Cinnamomi 140g, Radix Curcumae 140g, Fructus Crataegi 140g, Flos Sophorae 70g, Radix Aucklandiae 70g, Borneolum Syntheticum 5.5g; Disintegrating agent is appropriate, its for amount ratio be the polyvinylpolypyrrolidone of 2:1 and the combination of cross-linking sodium carboxymethyl cellulose.
Preparation method is with either method in embodiment 1 ~ 3.
Embodiment 7
500 tablet recipes are:
Radix Astragali 429g, Rhizoma Chuanxiong 288g, Radix Salviae Miltiorrhizae 217g, Radix Notoginseng 147g, Rhizoma Alismatis 147g, Ramulus Cinnamomi 137g, Radix Curcumae 149g, Fructus Crataegi 145g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; Disintegrating agent is appropriate, its for amount ratio be the polyvinylpolypyrrolidone of 2:1 and the combination of cross-linking sodium carboxymethyl cellulose.
Preparation method is with either method in embodiment 1 ~ 3.
More than be intended to further illustrate the present invention, scope of the present invention do not limited.Those skilled in the art can not depart from improvement and the change of scope and spirit to embodiment disclosed herein.
Claims (10)
1. have a Chinese medicinal tablet for eliminating thrombus and removing obstruction in channels effect, it is characterized in that, the raw material of this Chinese medicinal tablet is: the Radix Astragali 400 ~ 450 weight portion, Rhizoma Chuanxiong 250 ~ 300 weight portion, Radix Salviae Miltiorrhizae 200 ~ 250 weight portion, Radix Notoginseng 130 ~ 160 weight portion, Rhizoma Alismatis 130 ~ 160 weight portion, Ramulus Cinnamomi 130 ~ 160 weight portion, Radix Curcumae 130 ~ 160 weight portion, Fructus Crataegi 130 ~ 160 weight portion, Flos Sophorae 60 ~ 90 weight portion, the Radix Aucklandiae 60 ~ 90 amount part, Borneolum Syntheticum 5 ~ 8 weight portion;
This Chinese medicinal tablet is obtained by following preparation method:
(1) get the raw material outside above-mentioned Radix Notoginseng, Borneolum Syntheticum, add the warm water of 3 ~ 5 times amount and the compound enzyme of 3 ~ 5%, mixing, 45 ~ 55 DEG C are incubated enzymolysis 1 ~ 2 hour; Extract 2 times with steam distillation after adding water, collect volatile oil, add ethanol hold over night after concentrating filtrate merging, filter, filtrate recycling ethanol, concentrated, obtain extractum, extractum density 1.1 ~ 1.15 (50 DEG C); Described compound enzyme is the mixture of cellulase and pectase;
(2) Radix Notoginseng, Borneolum Syntheticum are pulverized respectively;
(3) the extractum that (2) step obtains is mixed with Radix Notoginseng powder, granulate, dry;
(4) to step (3) gained spraying particles volatile oil, add Borneolum Syntheticum powder and magnesium stearate, mixing, tabletting, film coating, to obtain final product.
2. Chinese medicinal tablet as claimed in claim 1, is characterized in that, the raw material of preparation 500 these Chinese medicinal tablets is: Radix Astragali 428-435g, Rhizoma Chuanxiong 285-290g, Radix Salviae Miltiorrhizae 210-220g, Radix Notoginseng 140-150g, Rhizoma Alismatis 140-150g, Ramulus Cinnamomi 140-150g, Radix Curcumae 140-150g, Fructus Crataegi 140-150g, Flos Sophorae 70-75g, Radix Aucklandiae 70-75g, Borneolum Syntheticum 5.5-6.0g; The Unit Weight of this Chinese medicinal tablet that described method obtains is 0.76g/ sheet.
3. Chinese medicinal tablet as claimed in claim 2, is characterized in that, the raw material of preparation 500 these Chinese medicinal tablets is: Radix Astragali 431g, Rhizoma Chuanxiong 287g, Radix Salviae Miltiorrhizae 215g, Radix Notoginseng 144g, Rhizoma Alismatis 144g, Ramulus Cinnamomi 144g, Radix Curcumae 144g, Fructus Crataegi 144g, Flos Sophorae 72g, Radix Aucklandiae 72g, Borneolum Syntheticum 5.7g; The Unit Weight of this Chinese medicinal tablet is 0.76g/ sheet.
4. Chinese medicinal tablet as claimed in claim 1, it is characterized in that, described compound enzyme is cellulase and the pectase of 3:1; Hydrolysis temperature is 50 DEG C, and enzymolysis time is 1 hour.
5. Chinese medicinal tablet as claimed in claim 1, it is characterized in that, the extracting method (1) of step described in this is specially: 8 ~ 10 times amount water extraction 1 hour first, second time 6 ~ 8 times of water gagings 0.5 hour.
6. Chinese medicinal tablet as claimed in claim 1, it is characterized in that, (1) described step is further: extract filtrate and be concentrated into 1:(1 ~ 2) ml/g, slowly adding ethanol to determining alcohol under stirring is 50% (v/v), leaves standstill 12 ~ 18 hours.
7. Chinese medicinal tablet as claimed in claim 1, it is characterized in that, (3) described step be Radix Notoginseng powder and disintegrating agent are mixed, and is added to soft material processed in the extractum of step (2) gained, granulation, drying.
8. Chinese medicinal tablet as claimed in claim 7, it is characterized in that, described disintegrating agent is polyvinylpolypyrrolidone and/or cross-linking sodium carboxymethyl cellulose.
9. Chinese medicinal tablet as claimed in claim 7, it is characterized in that, described disintegrating agent is amount ratio is the polyvinylpolypyrrolidone of 2:1 and the combination of cross-linking sodium carboxymethyl cellulose.
10. the Chinese medicinal tablet as described in claim 1 or 7, is characterized in that, the consumption of described disintegrating agent is 2 ~ 3%, and magnesium stearate consumption is 1%.
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| CN107164164A (en) * | 2017-07-16 | 2017-09-15 | 钱如贵 | A kind of preparation method of herb fermenting wine |
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Effective date of registration: 20191209 Address after: 064400 No. 2966, modern equipment manufacturing industry cluster, Qian'an City, Tangshan City, Hebei Province Patentee after: Hebei Baishan Pharmaceutical Co.,Ltd. Address before: 063000 Hebei Province, Tangshan City Road North North West Road No. 18 Patentee before: Han Zhiqiang |
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