CN1720988A - Thrombus eliminating, channel activating soft capsule and its preparation method - Google Patents
Thrombus eliminating, channel activating soft capsule and its preparation method Download PDFInfo
- Publication number
- CN1720988A CN1720988A CN 200510085600 CN200510085600A CN1720988A CN 1720988 A CN1720988 A CN 1720988A CN 200510085600 CN200510085600 CN 200510085600 CN 200510085600 A CN200510085600 A CN 200510085600A CN 1720988 A CN1720988 A CN 1720988A
- Authority
- CN
- China
- Prior art keywords
- parts
- soft capsule
- radix
- channels
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a soft capsule for thrombus eliminating and channel activating, wherein the content of the soft capsule comprises 10-70 wt% of medicinal powder and 30-90 wt% of auxiliary material, the medicinal powder comprises borneol, Ligusticum wallichii, root of red rooted saliva, astragalus root, oriental water plantain rhizome, notoginseng, pagodatree flower, cassia twig, curcuma aromatica, banksia rose and haw thorn.
Description
Technical field
The present invention relates to a kind of Chinese medicine and preparation technology thereof, particularly relate to a kind of Chinese medicinal soft capsule and preparation technology thereof.
Background technology
XIAOSHUAN TONGLUO JIAONANG is to extract purified pure Chinese medicinal preparation by Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Notoginseng, Flos Sophorae, Ramulus Cinnamomi, Radix Curcumae, the Radix Aucklandiae, Borneolum Syntheticum, Fructus Crataegi 11 flavor Chinese medicines through scientific method.Has blood circulation promoting and blood stasis dispelling, the promoting the flow of QI in the collateral by warming the meridian effect.Be used for the apoplexy due to the obstruction of collaterals by blood stasis, disease is seen stuttering puckery, the hands and feet coolness of dull expression, speech, limbs pain; Cerebral infarction and hyperlipemia are seen above-mentioned disease person.
The major defect that prior art exists is: at first, the medicine slow in absorption of human body of the medicine in the hard capsule takes effect slowly; Secondly, the hard capsule medicine distributes bitterness and bad smell easily, and the patient is not easy to accept; The 3rd, control than difficult with the concentrated type hard capsule medicine content uniformity that Chinese medicine extract is made; At last, hard capsule medicine sealing is poor, and the easy dissipation of volatile ingredient is gone out in the medicine, causes wherein effective ingredient reduction, can not preserve for a long time.
Goal of the invention
The objective of the invention is to overcome the defective of prior art, provide a kind of instant effect, patient acceptant, preserve soft capsule for eliminating thrombus and removing obstruction in channels easily.The preparation technology of soft capsule for eliminating thrombus and removing obstruction in channels is provided simultaneously.
Summary of the invention
The object of the invention adopts following technical scheme to realize.
Soft capsule for eliminating thrombus and removing obstruction in channels prescription of the present invention is made up of Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Notoginseng, Flos Sophorae, Ramulus Cinnamomi, Radix Curcumae, the Radix Aucklandiae, Borneolum Syntheticum, Fructus Crataegi 11 flavor Chinese medicines, and its weight proportion relation is: 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 2 parts of Radix Notoginseng, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 0.08 part of Borneolum Syntheticum, 2 parts of Fructus Crataegis.Contained effective ingredient of each medical material and pharmacological action division thereof are as follows in the prescription:
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Main product is in Sichuan.Rhizome contains volatile oil, and main constituent is a ligustilide; Nitrogen-containing compound, main constituent are ligustrazine; Neutral wet goods.Blood vessel dilating is arranged and reduce peripheral arterial resistance of blood flow effect through test, cerebral blood flow increasing amount, and can suppress biologically active pdgf, microcirculation improvement and analgesia, calmness, spasmolytic, antiinflammatory, antiabortive effect, and sudden deafness also had good curative effect.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Main product in Sichuan, Anhui, Jiangsu, Shanxi, Hebei etc.Radix Salviae Miltiorrhizae contains various active compositions such as salviol, danshensu, TANSHINONES, is used for the treatment of coronary heart disease, angina pectoris.The Treated with Radix Salviae Miltiorrhizae hepatopathy also had breakthrough in recent years.
The Radix Astragali: this product is the dry root of leguminous plant Radix Astagali Astragalus membranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch.) Bge..Main product in Shanxi, Heilungkiang, the Inner Mongol, Gansu.Astragalus root contains monosaccharide, polysaccharide, protein, Radix Astragali saponin I～VIII etc.Radix Astragali QI invigorating clots absorbing, collateral dredging, has enhancing immunity, the ability of enhanced virus inducement interferon, enhancing body anoxia enduring and stress ability promote organism metabolism, improve cardiac function, blood pressure lowering protects the liver, blood sugar regulation, antibiotic and suppress effect such as virus, experiment finds that it has the trend that reduces the cerebral ischemia scope.
Rhizoma Alismatis: this product is the dry tuber of Alismataceae plant Rhizoma Alismatis Alisma orientalis (Sam.) Juzep. (A.Plantago-aquaticaL.var.orientale Sam.).Main product in Fujian, Sichuan, Jiangxi.Rhizoma Alismatis contains Alisol A and B, acetic acid Alisol A ester and B ester isoreactivity composition, and modern age, pharmacological evaluation proved, Rhizoma Alismatis has tangible cholesterol reducing and anti-offshoot medicated porridge induration, and the treatment hyperlipidemia is had obvious curative effects.Experiment and human clinical use proof Rhizoma Alismatis lipid-lowering oral liquid has good effect to blood fat reducing, blood pressure lowering.
Radix Notoginseng: this product is the dry root of panax araliaceae plant Panax notoginseng (Burk.) F.H.Chen.This product main product ground: main product in Yunnan, Guangxi; Also produce in Sichuan, Guizhou, Jiangxi. and root contains ginsenoside (ginsenosides) Rb1, Rd, Re, Rg1, Rg2, Rh1,20-O-glucose Ginsenoside Rf, arasaponin (notoginsenoside) R1, R2, R3, R4, Herba Gynostemmatis Saponin (gypenoside) X VII, still contain the panaxosideRb2, also contain volatile oil.Aqueous extract still contains a kind of dencichine (N-oxalo-L-α, β-diaminopropionic acid) of tool styptic activity.Bibliographical information: Radix Notoginseng have extremely strong anastalsis; Radix Notoginseng total arasaponins and blood vessel dilating arranged, bring high blood pressure down, anti peroxidation of lipid, atherosclerosis and Antishock function; Flavonoid glycoside is the effective ingredient of coronary artery dilating; Radix Notoginseng total arasaponins can significantly improve the phagocytic activity of macrophage, improves blood leucocyte sum and lymphocyte percentage ratio; Radix Notoginseng total arasaponins has oxygen lack resistant function, can improve the Leptomeningeal microcirculation of anoxia animal, postpones the depleted time of cerebral circulation, and the damage of brain cortex cell has protective effect during to anoxia; Radix Notoginseng and leaf, the total Saponin of Hua all have tangible calmness and anticonvulsant action; Radix Notoginseng still has blood fat reducing, blood sugar lowering, diuresis, antioxidation, defying age, anti-experimental character hepatic injury, antiulcer and promotes effects such as albumen synthesizes.
Flos Sophorae: the dry flower and alabastrum of leguminous plant Chinese scholartree Sophora japonica L..The main place of production of this product: ground such as Hebei, Shandong, Henan, Jiangsu, Guangdong, Guangxi, Liaoning.Flos Sophorae contains globulariacitrin, Flos Sophorae Immaturus first element, second element, tannin isoreactivity composition.Flos Sophorae bitter in the mouth cool in nature has clearing away heat and cooling blood, purging liver-fire, hemostatic effect.It contains materials such as rutin, Quercetin, sophoradiol, vitamin A.Rutin can be improved the function of blood capillary, keeps the normal resistance of blood capillary, prevent because of capillary fragility excessive, hemorrhage, the hypertension that permeability is too high to be caused, diabetes, can preventing of clothes is hemorrhage.
Ramulus Cinnamomi: be the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl, the main place of production of this product: Guangxi, Guangdong, Hainan.Ramulus Cinnamomi contains volatile oil, is mainly cinnamic aldehyde, cinnamic acid.Cinnamic aldehyde has obvious sedation to mice according to the literature, spontaneous activity is reduced, and can resist that methamphetamine produces cross multi-activity and the movement disorder of the test induced mice of turning, still can prolong the length of one's sleep of soluble hexobarbital to mice.The Ramulus Cinnamomi decoct all has stronger inhibitory action to golden yellow and Staphylococcus albus, typhoid fever bacterium and common pathogenic dermatophytes.
Radix Curcumae: Radix Curcumae is the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chen.etC.Ling., Rhizoma Curcumae Longae Curcuma.longa L., Guangxi zedoary Curcuma.Kwangsiensis S.G.Lee et C.F.Liang or Rhizoma Curcumae Curcuma phaeocaulis Val., Rhizoma Curcumae Longae has another name called RADIX CURCUMAE from Sichuan of China, and Guangxi zedoary has another name called the osmanthus Radix Curcumae.Main product Zhejiang, Sichuan, Guangdong, Guangxi, Yunnan, Fujian, Taiwan, Jiangxi.The main component that contains in the volatile oil is curcumene (1-curcumene), sesquiterpene alcohols, Camphora, camphene, still contains curcumin, demethoxycurcumin, turmerone etc.
The Radix Aucklandiae: this product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Originate in ground such as India, Pakistan, also produce in Yunnan Province of China, Sichuan, Tibet, Guangdong, Guangxi in recent years.Contain constuslactone (cosiuslacione), dihydrocostulactone (dihydrocostuslactone), Saussurea Lactone (saussurealactone), costunolide (costunolide), dihydro costunolide (dihyd-rocostunolide) etc.
Borneolum Syntheticum: borneolum syntheticum.The refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for calentura coma, convulsions, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Fructus Crataegi: this product is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge..Its main component is triterpene and flavone.The energy anticoagulant, coronary artery dilator improves blood supply of cardiac muscle, reduces myocardial oxygen consumption, ischemic heart desease is produced significant protective effect, and have blood fat reducing, the effect of blood pressure lowering.Be applicable to coronary heart disease, coronary insufficiency, angina pectoris and treatment cardiovascular disease etc.
The specific embodiment
According to the prescription medical material ingredient character of respectively distinguishing the flavor of, we take following prepared soft capsule for eliminating thrombus and removing obstruction in channels:
The medicated powder that soft capsule for eliminating thrombus and removing obstruction in channels is made up of extract powder, Borneolum Syntheticum 10-70% weight and the adjuvant mix homogeneously of 30-90% weight are made soft capsule content, with capsule casing material with the soft capsule content system of dripping or be pressed into soft capsule.
The raw extract powder preparation:
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water more than 1 time, amount of water is 6-10 times, decocting time is 1-2 hour, merges decocting liquid, filters, filtrate 60-100 ℃ is concentrated into relative density 1.17-1.19 (70 ℃), add 2 parts of Radix Notoginseng fine powder dryings, pulverize in (more than 100 orders), get extract powder.
Soft capsule preparation:
Soft capsule for eliminating thrombus and removing obstruction in channels of the present invention can prepare by the various appropriate method of soft capsule preparation, preferably make: with extract powder and the lytic agent (Polyethylene Glycol of PEG400 or PEG600 liquid state by being prepared as follows method, fish oil, olive oil, Semen Maydis oil, soybean oil, refining Oleum Arachidis hypogaeae semen, Radix Oenotherae erythrosepalae oil, Herba Silybi mariani oil, Oleum Vitis viniferae, Oleum Ricini, Oleum Helianthi, safflower oil, in the Fructus Hippophae wet goods vegetable and animals oils any one), cosolvent (propylene glycol, glycerol, the mixture of lower alcohols such as isopropyl alcohol and/or several alcohol, zein, hydrogenated palm oil, triglyceride, diglyceride, glyceryl monoacetate, soybean lecithin, lecithin, polyglycerin ester, sucrose ester a kind of or several), suspending agent (PEG4000, the Polyethylene Glycol that PEG6000 is solid-state, aerosil, liquid paraffin, lanoline, Cera Flava, glyceryl monostearate, in the high fatty alcohol a kind of or several), surfactant (sorbester p17, sorbester p18, Tween 80, polysorbate60, sodium lauryl sulphate, neutral liquid ester, in the poloxamer a kind of or several) in one and/or a plurality of mixing, add Borneolum Syntheticum and cross the content of colloid mill mix homogeneously system, adopt the system of dripping or pressing to prepare soft capsule, soft capsule is through solidifying by cooling in wind, dry, wash ball with appropriate solvent, do eventually, promptly.
Beneficial effect of the present invention is embodied in following aspect:
1, medicine absorbs in human body steadily, has improved bioavailability, stable curative effect;
2, product hermeticity is good, has stoped distributing of bitterness and bad smell, and effective ingredient is not easy oxidation and volatilization, and the patient is acceptant, and can long-term storage:
3, effective ingredient is even, and every capsules content uniformity is more easy to control.
Enumerate several embodiment that are used to that the invention process process is described rather than are used for limiting protection domain, as follows:
The used medical material of the present invention is all checked down according to Rhizoma Chuanxiong of version Chinese Pharmacopoeia in 2000, Radix Salviae Miltiorrhizae, the Radix Astragali, Rhizoma Alismatis, Radix Notoginseng, Flos Sophorae, Ramulus Cinnamomi, Radix Curcumae, the Radix Aucklandiae, Borneolum Syntheticum, Fructus Crataegi item, and is standby after picking clean system.
Embodiment 1
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 2 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocted 1.5 hours for the second time, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.
Embodiment 2
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, PEG600, glycerol, PEG6000 are mixed, adds 0.08 part of Borneolum Syntheticum and cross the colloid mill mix homogeneously and make content, adopt pressing to prepare soft capsule, soft capsule is washed ball, dried eventually with appropriate solvent, promptly through solidifying by cooling in wind, drying.
Embodiment 3
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, PEG400, propylene glycol, PEG4000 are mixed, adds 0.08 part of Borneolum Syntheticum and cross the colloid mill mix homogeneously and make content, adopt pressing to prepare soft capsule, soft capsule is washed ball, dried eventually with appropriate solvent, promptly through solidifying by cooling in wind, drying.
Embodiment 4
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, olive oil, triglyceride, aerosil, Tween 80 are mixed, add 0.08 part of Borneolum Syntheticum and cross the colloid mill mix homogeneously and make content, adopt dropping preparation method to prepare soft capsule, soft capsule is through solidifying by cooling in wind, drying, wash ball, do eventually, promptly with appropriate solvent.
Embodiment 5
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, Semen Maydis oil, soybean lecithin, Cera Flava, poloxamer are mixed, add 0.08 part of Borneolum Syntheticum and cross the colloid mill mix homogeneously and make content, adopt dropping preparation method to prepare soft capsule, soft capsule is through solidifying by cooling in wind, drying, wash ball, do eventually, promptly with appropriate solvent.
Embodiment 6
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, Oleum Vitis viniferae, diglyceride, lanoline, sorbester p18 are mixed, add 0.08 part of Borneolum Syntheticum and cross the colloid mill mix homogeneously and make content, adopt pressing to prepare soft capsule, soft capsule is through solidifying by cooling in wind, drying, wash ball, do eventually, promptly with appropriate solvent.
Embodiment 7
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.Extract powder, refined soybean oil, hydrogenated palm oil, aerosil, neutral liquid ester are mixed, adding 0.08 part of Borneolum Syntheticum crosses the colloid mill mix homogeneously and makes content, adopt pressing to prepare soft capsule, soft capsule is through solidifying by cooling in wind, drying, wash ball, do eventually, promptly with appropriate solvent.
Soft capsule for eliminating thrombus and removing obstruction in channels and commercially available XIAOSHUAN TONGLUO JIAONANG by preparation method preparation of the present invention compare anti-thrombosis function:
18 of male wistar rats are divided into 3 groups at random, soft capsule for eliminating thrombus and removing obstruction in channels and commercially available XIAOSHUAN TONGLUO JIAONANG 1 gastric infusion, two groups of every days of preparation method preparation of the present invention, continuous 7 days.After the last administration 1 hour, in the rat aorta blood sampling, carry out external thrombus and form test, survey its thrombosis length, weight in wet base, dry weight.The results are shown in following table.
| Thrombosis length (cm) | Weight in wet base (g) | Dry weight (g) | |
| The blank group | 11.6±2.2 | 0.80+0.01 | 0.112±0.018 |
| The XIAOSHUAN TONGLUO JIAONANG group | 3.1±0.1* | 0.19±0.04* | 0.028±0.005* |
| The soft capsule for eliminating thrombus and removing obstruction in channels group | 3.0±0.3* | 0.21±0.02* | 0.027±0.003* |
*P＜0.05 is compared with the blank group
The result as seen, soft capsule for eliminating thrombus and removing obstruction in channels and commercially available XIAOSHUAN TONGLUO JIAONANG all can significantly suppress thrombus length, reduce thrombus weight, illustrate that this product has tangible anti-thrombosis function.
Claims (8)
1, a kind of soft capsule for eliminating thrombus and removing obstruction in channels, it is characterized in that it is by the medicated powder of 10-70% weight and the adjuvant mix homogeneously of 30-90% weight, make soft capsule content, with capsule casing material with the soft capsule content system of dripping or be pressed into soft capsule, wherein, described adjuvant comprises lytic agent liquid polyethylene glycol and/or vegetable and animals oils at least; Described medicated powder is made by 0.08 part of Borneolum Syntheticum with by the following weight proportion raw material: 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 2 parts of Radix Notoginseng, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis.
2, soft capsule for eliminating thrombus and removing obstruction in channels according to claim 1 is characterized in that described extract powder adopts following prepared:
With 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of water that add 6-10 times of raw material dry weight of Fructus Crataegi, extract each 1-2 hour 1-3 time; Collecting decoction filters, and it is the clear paste of 1.17-1.19 that filtrate decompression is concentrated into 70 ℃ of survey relative densities, adds 2 parts of Radix Notoginseng fine powders, and drying is crushed to more than 100 orders, and is standby.
3, soft capsule for eliminating thrombus and removing obstruction in channels according to claim 2 is characterized in that described drying is dry below 80 ℃.
4,, it is characterized in that described soft capsule adopts following prepared according to the described soft capsule for eliminating thrombus and removing obstruction in channels of claim 1-3:
Get 4 parts of Rhizoma Chuanxiongs, 3 parts of Radix Salviae Miltiorrhizaes, 6 parts of the Radixs Astragali, 2 parts of Rhizoma Alismatis, 1 part in Flos Sophorae, 2 parts of Ramulus Cinnamomi, 2 parts of Radix Curcumaes, 1 part of the Radix Aucklandiae, 2 parts of Fructus Crataegis, decoct with water 3 times, decocted 1.5 hours for the first time, amount of water is 10 times, decocts 1.5 hours for the second time, and amount of water is 8 times, decocted for the third time 1 hour, amount of water is 8 times, merges decocting liquid, filters, filtrate is concentrated into 70 ℃ for 80 ℃ and surveys relative density 1.17-1.19, add 2 parts of Radix Notoginseng fine powder dryings, be crushed to more than 100 orders, get extract powder.With one and/or a plurality of mixing the in extract powder and lytic agent, cosolvent, suspending agent, the surfactant, add 0.08 part of Borneolum Syntheticum and cross the content of colloid mill mix homogeneously system, adopt the system of dripping or pressing to prepare soft capsule, soft capsule is through solidifying by cooling in wind, drying, wash ball, do eventually, promptly with appropriate solvent.
5, according to the described soft capsule for eliminating thrombus and removing obstruction in channels of claim 1-4, it is characterized in that described lytic agent be in the Polyethylene Glycol, fish oil, olive oil, Semen Maydis oil, soybean oil of PEG400 or PEG600 liquid state, refining Oleum Arachidis hypogaeae semen, Radix Oenotherae erythrosepalae oil, Herba Silybi mariani oil, Oleum Vitis viniferae, Oleum Ricini, Oleum Helianthi, safflower oil, the Oleum Hippophae any one or several.
6, according to the described soft capsule for eliminating thrombus and removing obstruction in channels of claim 1-5, it is characterized in that described adjuvant also comprises cosolvent, described cosolvent is mixture, zein, hydrogenated palm oil, triglyceride, diglyceride, glyceryl monoacetate, soybean lecithin, lecithin, polyglycerin ester, sucrose ester a kind of of lower alcohols such as propylene glycol, glycerol, isopropyl alcohol and/or several alcohol or several.
7, according to the described soft capsule for eliminating thrombus and removing obstruction in channels of claim 1-6, it is characterized in that described adjuvant also comprise in the solid-state Polyethylene Glycol of suspending agent PEG4000, PEG6000, aerosil, liquid paraffin, lanoline, Cera Flava, glyceryl monostearate, the high fatty alcohol a kind of or several.
8, according to the described soft capsule for eliminating thrombus and removing obstruction in channels of claim 1-7, it is characterized in that described adjuvant also comprise in surfactant sorbester p17, sorbester p18, Tween 80, polysorbate60, sodium lauryl sulphate, neutral liquid ester, the poloxamer a kind of or several.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510085600 CN1720988A (en) | 2005-07-29 | 2005-07-29 | Thrombus eliminating, channel activating soft capsule and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510085600 CN1720988A (en) | 2005-07-29 | 2005-07-29 | Thrombus eliminating, channel activating soft capsule and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1720988A true CN1720988A (en) | 2006-01-18 |
Family
ID=35911825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510085600 Pending CN1720988A (en) | 2005-07-29 | 2005-07-29 | Thrombus eliminating, channel activating soft capsule and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1720988A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856968A (en) * | 2015-05-27 | 2015-08-26 | 韩志强 | Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof |
| CN105148202A (en) * | 2015-10-13 | 2015-12-16 | 哈尔滨市康隆药业有限责任公司 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation thereof |
| CN114569662A (en) * | 2022-03-08 | 2022-06-03 | 赵钢 | Preparation method of soft capsule for treating arteriosclerosis |
-
2005
- 2005-07-29 CN CN 200510085600 patent/CN1720988A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104856968A (en) * | 2015-05-27 | 2015-08-26 | 韩志强 | Traditional Chinese medicine tablet with effects of removing thrombus and dredging collaterals and preparation method thereof |
| CN104856968B (en) * | 2015-05-27 | 2018-02-09 | 韩志强 | A kind of Chinese medicinal tablet with eliminating thrombus and removing obstruction in channels effect and preparation method thereof |
| CN105148202A (en) * | 2015-10-13 | 2015-12-16 | 哈尔滨市康隆药业有限责任公司 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation thereof |
| CN114569662A (en) * | 2022-03-08 | 2022-06-03 | 赵钢 | Preparation method of soft capsule for treating arteriosclerosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Scutellaria baicalensis Georgi.(Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology | |
| CN101167906A (en) | Medicinal composition for reducing blood lipid and reducing weight and preparation process thereof | |
| CN104161704B (en) | The pure natural shampoo that herbal raw material makes | |
| CN101502588B (en) | Composition for beauty treatment and removing blain and method for preparing the same | |
| Xin et al. | Belamcanda chinensis (l.) Dc: Ethnopharmacology, phytochemistryand pharmacology of an important traditional Chinese medicine | |
| CN103202790A (en) | Purely natural shampoo | |
| CN102475830B (en) | Medicinal composition for treating coronary disease and angina pectoris, preparation method thereof and preparation thereof | |
| CN1720988A (en) | Thrombus eliminating, channel activating soft capsule and its preparation method | |
| CN106580779A (en) | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof | |
| CN1277572C (en) | Medicinal composition for treating ulcerative colitis and its preparing method | |
| CN106039148B (en) | Liver-protecting Mongolian medicine | |
| CN104274568A (en) | Anti-fatigue compound preparation and preparation method thereof | |
| CN101543532A (en) | Traditional Chinese medicine for treating coronary disease, angina pectoris and apoplexy sequelae and preparation method thereof | |
| CN103845616A (en) | Pharmaceutical composition for eliminating inflammation and disinfecting | |
| CN1726955A (en) | Compound soft capsule of earthworm and preparation method | |
| CN102755519B (en) | Kudzuvine root-kudzuvine flower anti-canker sore particle and preparation method thereof | |
| CN1785245A (en) | Method for preparing composite traditional Chinese medicine soft capsule | |
| CN1285372C (en) | Chinese medicine oral preparation for treating gynecologic inflammation and its preparation method | |
| CN108379199A (en) | A kind of plant mask powder | |
| CN101837107A (en) | Traditional Chinese medicine for curing acute and chronic cholecystitis, biliary tract infection, gall-stone, and biliary tract postoperative syndromes | |
| CN105079198A (en) | Traditional Chinese medicinal composition for treating breast hyperplasia, oral preparation and preparation method of oral preparation | |
| CN105311335A (en) | Traditional Chinese medicine composition for assisting tumor chemoradiotherapy | |
| CN105250931A (en) | Pharmaceutic preparation for treating stenocardia | |
| CN106110190B (en) | A kind of Chinese medicine composition and Chinese materia medica preparation of nourishing blood for regulating menstruation | |
| Li et al. | The phytochemistry, pharmacology, pharmacokinetics, quality control, and toxicity of Forsythiae Fructus: A updated systematic review. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |