CN111419983B - Kidney-nourishing blood-nourishing paste - Google Patents

Abstract

An electuary for nourishing kidney and blood, relates to a Chinese medicinal preparation, in particular to a Chinese medicinal compound preparation for regulating menstruation, assisting pregnancy and preventing miscarriage. The kidney nourishing and blood nourishing paste comprises, by weight, 10-50 parts of semen cuscutae, 10-40 parts of morinda officinalis, 10-30 parts of epimedium, 10-30 parts of cistanche, 10-30 parts of eucommia ulmoides, 10-50 parts of teasel roots, 10-50 parts of glossy privet fruits, 10-50 parts of mulberries, 10-50 parts of codonopsis pilosula, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of Chinese yams, 10-30 parts of angelica, 10-30 parts of white paeony roots, 6-40 parts of radix rehmanniae and 6-30 parts of dendrobium. The prescription of the invention can safely and effectively regulate the menstrual cycle, increase the menstrual flow, regulate the ovarian function, improve the thin endometrium and improve the ovum taking rate of assisted reproduction.

Description

Kidney-nourishing blood-nourishing paste

Technical Field

The invention relates to a Chinese medicinal compound preparation for regulating menstruation, assisting pregnancy and preventing miscarriage and a preparation method thereof.

Background

Women have special physiological and pathological changes in different stages of menstruation, pregnancy, birth, lactation and the like, and are easy to consume qi and hurt blood, damage liver and kidney, and damage thoroughfare and conception vessels, and modern women bear heavy burden in various aspects of work, families and society, strain and emotional pressure easily cause viscera dysfunction and imbalance of qi, blood, yin and yang, so that various diseases such as irregular menstruation, dysmenorrhea, amenorrhea, infertility, habitual abortion and the like are caused. Irregular menstruation is the most common disease in gynecologic clinical practice in traditional Chinese medicine, and infertility and the like caused by irregular menstruation, while menstruation regulation is the characteristic and the advantage of gynecologic in traditional Chinese medicine. However, many menstrual diseases need to be treated for a long time, are difficult to see success for a short time, and need a relatively simple medicine to meet the requirements of patients. For the treatment of menstrual disorder, expecting therapy or hormone such as progestational therapy, female-progestational therapy and the like is generally adopted in western medicine, but the problems of repeated disease after stopping taking medicine, or incapability of taking medicine due to contraindications such as thrombosis risk, estrogen-dependent tumor and the like exist in part of patients exist. Therefore, it is expected by the clinical gynecologist to find a safer and more effective method for improving menstruation and treating menstrual diseases.

Women have no children and can be adjusted to make children feel a new child because of irregular menstruation. Irregular menstruation is usually the precursor of infertility. Regulating menstruation is also essential for seeds. In the Su Wen (plain questions), the regulation of yin and yang is based on the peace period, which embodies the essence of the traditional Chinese medicine. Regulating menstruation, no drastic drugs need to be administered, and the physiological and pathological characteristics of women need to be taken care of, so as to comply with the functional characteristics of the body at different periods and restore the balance of qi, blood, yin and yang. Zhang Liang Ying professor treats irregular menstruation, the frequency of using tonics and qi-tonifying blood is high, the effect of kidney essence and kidney qi on pregnancy is emphasized, the tonics take the kidney-tonifying herbs as the core, and on the basis, the syndrome differentiation and treatment are performed by examining the cause. However, many patients may have fertility requirements while regulating menstruation, and the prescription should be taken in consideration of the possibility of pregnancy due to improvement of the condition after the patients take the medicine.

Disclosure of Invention

The invention aims to provide a Chinese medicinal preparation for regulating menstruation, assisting pregnancy and preventing miscarriage, which has the aim of clinical treatment by tonifying kidney, nourishing blood and regulating menstruation.

The kidney nourishing and blood nourishing paste is characterized by comprising, by weight, 10-50 parts of semen cuscutae, 10-40 parts of morinda officinalis, 10-30 parts of epimedium, 10-30 parts of cistanche, 10-30 parts of eucommia ulmoides, 10-50 parts of teasel roots, 10-50 parts of glossy privet fruits, 10-50 parts of mulberries, 10-50 parts of codonopsis pilosula, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of Chinese yams, 10-30 parts of angelica sinensis, 10-30 parts of white paeony roots, 6-40 parts of radix rehmanniae recen and 6-30 parts of dendrobium nobile.

The prepared dodder and morinda root salt can enter the kidney channel to play a role of tonifying the kidney when being used as a medicine.

The preparation is a soft extract, and the preparation process comprises the following steps:

s1, decocting: soaking decoction pieces in the preparation in water for 1-4 hr, decocting for 2-3 times, filtering decoction after each decoction for 1-2 hr, squeezing decoction dregs, mixing squeezed liquid and filtered decoction, standing, clarifying, and filtering;

s2, concentrating: heating and concentrating the decoction to obtain fluid extract;

s3, refining honey: dissolving Mel in water, filtering, and heating and decocting to obtain refined Mel;

s4, collecting paste: adding refined honey into the clear paste, adding 300 g of refined honey into every 1000 g of clear paste, stirring, heating and decocting to obtain the paste in a white thread state.

The clear paste is concentrated and is dripped on mulberry paper, and the best condition is that no water seeps around the dripping.

In the honey refining process, honey is heated until light yellow glossy billowing uniform fine bubbles appear, the honey is twisted by hands to have viscosity, and no white thread appears optimally when two fingers are separated.

In the paste collecting process, the refined honey is added and then is stirred clockwise, and foams on the liquid surface need to be fished out when the paste is heated.

The white thread making is that the paste liquid is dripped on the forefinger to be twisted with the thumb together, and the white thread with the length of about 2cm can be pulled out.

The soft extract is prepared, subpackaged in clean, dry and sterilized wide-mouth containers, covered and sealed after being sufficiently cooled, and stored in a shade place.

In the formula, semen cuscutae, cistanche, morinda officinalis and epimedium are used as monarch drugs, eucommia ulmoides, teasel roots, glossy privet fruits and mulberry are used as a first group of ministerial drugs, codonopsis pilosula, bighead atractylodes rhizome and Chinese yam are used as a second group of ministerial drugs, and radix rehmanniae, dendrobe, white paeony root and angelica are used as a third group of ministerial drugs and adjuvant drugs.

The preparation of the invention takes tonifying kidney and nourishing blood as main treatment methods. The reason for tonifying the kidney is that traditional Chinese medicine considers that the generation of menstruation is dominated by the kidney. The term "kidney-qi exuberance", "Tian Dec until", "ren Tong Chong Sheng", "uterus zang Xie", and "the moon is in the lower time", wherein the kidney-qi exuberance is the root. As described in foucault girl: "menstrual blood is the water of the first day, which comes from the kidney". The theory of kidney-sex-Chong-ren-uterus axis which is generally agreed by modern traditional Chinese medicine and used for regulating the menstrual cycle starts from the aspects of western medicine endocrine and nervous system regulation, the sex-stimulating hormone in traditional Chinese medicine is considered to be similar to various nerve regulating hormones secreted by the gonads, and the function of "being in the free circulation and the exuberance" in traditional Chinese medicine comprises the function of the gonads. Therefore, for the treatment of menopathy, attention is paid to tonifying kidney essence to regulate the axis of kidney-Tiandeca-Chong-ren-uterus to recover the function of "Chong-Sheng", and improve the reproductive endocrine. The kidney governs reproduction, discharges kidney through water and is the root of female growth and reproduction, the deficiency of the kidney is the common syndrome type of many gynecological diseases, and the tonifying kidney is an important treatment method for treating gynecological diseases. Therefore, the dodder, the cistanche, the morinda officinalis and the epimedium are used as the monarch in the formula, and the traditional Chinese medicine composition has the effects of tonifying the kidney, replenishing essence, tonifying thoroughfare and conception vessels, nourishing blood and regulating menstruation. Eucommia bark, teasel root, glossy privet fruit and mulberry are taken as a first group of ministerial drugs, the endocrine function can be improved by regulating the balance between kidney-sex-stimulating-uterus, the therapeutic effect is played by improving the function of hypothalamus-pituitary-ovarian axis, and the yin-yang balance state of the organism is maintained. The ministerial drug can strengthen the effects of invigorating kidney, replenishing essence and nourishing blood of the monarch drug, treat irregular menstruation, especially in the later stage of menstruation, hypomenorrhea and consumptive disease belonging to patients with spleen and kidney deficiency and deficiency of qi and blood, and can strengthen the body resistance and Chong root to consolidate the constitution.

The spleen and stomach are the acquired root, so the food and medicine depend on qi to collect juice, generate essence and transform. The medicines for tonifying the kidney, replenishing essence, nourishing the blood and benefiting the marrow are slightly greasy, are easy to obstruct the spleen and the stomach, have thin gastrointestinal essence, are not resistant to nourishing, have no nourishing effect at present if the medicines are not combined with products for tonifying the spleen and the stomach, have the symptoms of fullness, abdominal distension and loose diarrhea, are in the same source of qi and blood, and are homologous with the spleen and the kidney, so the codonopsis pilosula, the bighead atractylodes rhizome and the dioscorea opposita thumb are taken as a second group of ministerial medicines, are capable of tonifying the spleen, replenishing qi, assisting transportation and transformation, are nourished in the future, are innate, and prevent the paste from nourishing the greasy and obstructing the stomach.

The female is damaged by blood and yin deficiency due to the fact that the female produces milk frequently during pregnancy, so that radix rehmanniae, dendrobium, radix paeoniae alba and angelica sinensis are used as a third group of ministerial drugs and adjuvant drugs, and the radix rehmanniae can clear heat and cool blood, promote the production of body fluid and moisten dryness; herba Dendrobii has effects of benefiting stomach, promoting fluid production, nourishing yin and clearing heat; angelica has soft and moist property, and has the functions of replenishing blood and regulating blood, regulating menstruation, relieving pain, moistening dryness and lubricating intestines; white peony root, radix Paeoniae alba has the actions of nourishing blood, regulating nutrient, relieving spasm and pain, astringing yin and calming liver.

The medicines can nourish blood, regulate nutrient, nourish liver, nourish yin, clear heat and promote fluid production, are used together with the kidney-tonifying essence-replenishing yang-warming medicines to nourish yin and yang and to supplement water and fire, and can be used as adjuvant medicines to assist other medicines to warm and warm so as to prevent the paste from warming dryness, transforming heat and damaging yin. And collecting the paste with honey, and decocting to obtain the final product, wherein the medicines have the effects of treating liver, spleen and kidney, regulating qi, blood, essence and body fluid, tonifying yin and yang, and regulating both deficiency and excess.

The preparation of the invention is prepared into soft extract, is one of the traditional dosage forms of pill, powder, ointment, pill and the like in traditional Chinese medicine, is an important method for regulating and treating diseases, is a unique regulating and nourishing mode in traditional Chinese medicine, and has double effects of nutrition and nourishing as well as disease prevention and treatment.

The compatibility of the preparation of the invention is characterized in that the preparation does not cause excessive heat to cause movement of the liver and cause inflammation, or causes cold and cool to defeat the spleen and stomach, not only does not cause too much greasy taste to hinder transportation and transformation, but also does not cause too much ascending and scattering to cause no essence storage. Semen Cuscutae, Cistanchis herba, herba Epimedii, and radix Morindae officinalis with yang warming effect are combined with radix rehmanniae, fructus Ligustri Lucidi, herba Dendrobii, and radix Paeoniae alba with yin nourishing effect to make yin and yang grow mutually, harmonize qi and blood, and make dynamic and static phases appropriate, and radix Codonopsis, Atractylodis rhizoma, and rhizoma Dioscoreae are combined to assist transportation and transformation to protect spleen and stomach and prevent greasy taste from obstructing stomach. The soft extract has convenient administration, good taste compared with decoction, and long-term administration.

For the indications of the preparation, the diagnosis standards of preceeded menstruation, later period of menstruation, irregular menstruation sequence, scanty menstruation, excessive menstruation, menostaxis, dysmenorrheal, amenorrhea and metrorrhagia and metrostaxis in the teaching materials of the new century, the gynecology and obstetrics, and the guiding principles of clinical research on new traditional Chinese medicines issued by the Ministry of public health of the people's republic of China in 2002 are referred. The preparation can be taken alone or in combination during menstrual cycle, menstrual period, irregular menstrual flow, or accompanied by pain and discomfort of waist and abdomen. The method comprises the following steps:

(1) the kidney deficiency syndrome is characterized by: the menses color is dark and the menses quality is thin; secondly, the face color is dark or has dark spots; ③ lumbosacral soreness; fourthly, the knee is soft with sour shank or the heel is painful; tinnitus or deafness; sixthly, the sexual desire is declined; the tongue is dark and the coating is thin; eighthly, the two feet have deep and weak pulse.

(2) The spleen deficiency syndrome (qi deficiency syndrome) is characterized by: the color of the channels is light red, and the channels are thin; second, mental fatigue and hypodynamia; thirdly, qi deficiency and no speaking desire; fourthly, spontaneous perspiration; pale and swollen tongue or with tooth marks; sixthly, the pulse is weak, soft and soft;

the use symptoms of the preparation can be diagnosed by (1) the kidney deficiency syndrome or (2) the spleen deficiency syndrome (qi deficiency syndrome) and any 3 other manifestations. The first manifestation of kidney deficiency or spleen deficiency is the prerequisite, and the other manifestations are any 3 of the two syndromes, so the preparation can be used.

The application method of the preparation is that the preparation is orally taken in the morning and evening by 20g each time, is taken with boiled water after meals, and is stopped taking during menstrual period. The treatment period is 1 treatment course for 1 month. The follow-up visit is carried out for 3 months after the medicine is stopped in the recovery case.

Generally, the cure criteria are: the menstrual cycle, menstrual period and menstrual volume are recovered to be normal; the clinical symptoms disappear or basically disappear, and the clinical symptoms are maintained for more than 3 months.

The treatment effect standard is as follows: the menstrual cycle is recovered for 21-35 days, the menstrual period is recovered within 7 days, the menstrual amount is close to normal, the clinical symptoms are obviously improved, and the menstrual cycle lasts for more than 3 months.

The criteria for therapeutic efficacy are: the menstruation volume is increased, the menstruation quality is improved, the time after menstruation is staggered is shortened, but the menstrual cycle is not normal; the clinical symptoms were all improved but not continued for a 3 month period.

Criteria for treatment ineffectiveness were: no improvement in menstrual cycle, menstrual period, and menstrual flow; the clinical symptoms are not obviously improved or even aggravated.

After 117 patients with irregular menstruation took the preparation of the invention, the treatment results were counted, and 1 patient (0.9%) was cured clinically, 54 patients (46.1%) were effective, 51 patients (43.5%) were effective, and 11 patients (9.5%) were ineffective. After the treatment is finished, the total effective rate of the treatment of 117 patients is 90.5%. See Table-1. The formula is proved to have obvious effect of treating the irregular menstruation, achieves the aim of clinical treatment and has no obvious adverse reaction in the treatment process.

Detailed Description

Example 1: dungji, female, 36 years old, first diagnosis in 2018, 8 months and 17 days.

The main complaints are: the amount of menstruation was 1 year less.

The current medical history: the menstruation amount is small, 2 days are net, and the period is 22-26 days in the last year. lmp is 8.14, small in amount, light red, thin in texture, abdominal pain, mental fatigue, loose stool and waist soreness; pale and swollen with teeth marks and thin and white coating; deep and thready.

History of hypothyroidism.

And (3) diagnosis: hypomenorrhea.

Syndrome differentiation: deficiency of both spleen and kidney, deficiency of both qi and blood.

The therapeutic method adopts a prescription of 20g of dodder, 15g of morinda officinalis, 15g of epimedium, 15g of cistanche, 20g of eucommia, 20g of teasel root, 30g of glossy privet fruit, 20g of mulberry, 30g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 30g of dioscorea opposita, 10g of angelica, 12g of white paeony root, 6g of radix rehmanniae and 6g of dendrobium.

The 7-component ointment is prepared into nourishing ointment, and the nourishing ointment is taken with boiled water once a day in the morning and at night, one spoon for each time. It can be taken after meals or on an empty stomach.

The patient takes the second diagnosis in 2018, 9 and 11 days, after taking the medicine, the patient has the symptoms of lassitude, hypodynamia, loose stool and obviously relieved soreness of the waist, the lmp is 9.8, the quantity is increased compared with the former quantity, the color is red, and the abdomen is dull and painful; pale and swollen with teeth marks and thin and white coating; deep and thready.

Continuously taking the formula 7 nourishing paste.

20g of semen cuscutae, 15g of morinda officinalis, 15g of herba epimedii, 15g of cistanche, 20g of eucommia ulmoides, 20g of teasel root, 30g of glossy privet fruit, 20g of mulberry, 30g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 30g of common yam rhizome, 10g of angelica, 12g of white paeony root, 6g of radix rehmanniae and 6g of dendrobium.

Patients with three diagnoses in 2018, 10 months and 9 days have tired feeling, loose stool and no waist soreness after taking the medicine, the Lmp is 10.5, the dosage is moderate, the color is red, and the disease is clean; pale and swollen with thin and white coating; deep pulse. The spleen, kidney, qi and blood recover from the disease mechanism.

Continuously taking the 7-component nourishing paste for consolidation treatment.

The disease is returned after half a year, and the previous diseases are not sent again.

Example 2: jin in Chi, woman, age 22, first diagnosis in 2019, 7 months and 2 days.

The main complaints are: more than 20 days after menstruation and more than 1 year.

The current medical history: delayed menstruation for 1 year, 1-2 months, pmp of 4.7, lmp of 5.30, small amount, pale dark color, thin and clear quality for 7 days, mental fatigue and hypodynamia, soreness and weakness of waist and knees, and tinnitus. Pale and dark tongue with white coating; deep and thready. 5.19 color ultrasound: 0.7cm of endometrium and 1cm of hysteromyoma;

and (3) diagnosis: late menstrual cycle.

Syndrome differentiation: deficiency of both spleen and kidney, deficiency of both qi and blood.

The therapeutic method adopts a prescription of 30g of dodder, 20g of morinda officinalis, 15g of epimedium, 20g of cistanche, 20g of eucommia, 20g of teasel root, 20g of glossy privet fruit, 20g of mulberry, 20g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 20g of dioscorea opposita, 20g of angelica, 15g of white paeony root, 20g of radix rehmanniae and 6g of dendrobium.

The above 8 preparations are prepared into ointment, and are taken with boiled water once a day in the morning and at night, one spoon each time. It can be taken after meals or on an empty stomach.

And B, diagnosis: 8 and 11 months in 2019.

lmp is 7.8-7.15, the amount is increased compared with the previous amount, the color is redder, and the tiredness and the hypodynamia are relieved; pale and dark tongue with white coating; deep and thready.

For consistent syndrome, the kidney-nourishing and blood-nourishing paste should be used before the treatment according to the differentiation.

30g of semen cuscutae, 20g of morinda officinalis, 15g of herba epimedii, 20g of cistanche, 20g of eucommia ulmoides, 20g of teasel root, 20g of glossy privet fruit, 20g of mulberry, 20g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 20g of common yam rhizome, 20g of angelica, 15g of white paeony root, 20g of radix rehmanniae and 6g of dendrobium.

The dose is 6, the usage is the same as before.

Three diagnoses: 8 and 30 months in 2019

The dosage is improved, the pmp is 7.8 to 7.15, and the dosage is medium. Lmp is 8.7, clean in 6 days, moderate in dose, and distending pain in breast. No special discomfort exists.

The tongue is pale red with thin and white coating; deep and thready.

Kidney and spleen are healthy, and qi and blood are tonified. Strengthen the curative effect and keep the prescription on the spot.

30g of semen cuscutae, 20g of morinda officinalis, 15g of herba epimedii, 20g of cistanche, 20g of eucommia ulmoides, 20g of teasel root, 20g of glossy privet fruit, 20g of mulberry, 20g of codonopsis pilosula, 15g of bighead atractylodes rhizome, 20g of common yam rhizome, 20g of angelica, 15g of white paeony root, 20g of radix rehmanniae and 6g of dendrobium.

The dose is 6, the usage is the same as before.

The above examples 1 and 2 are different in disease name, though they are irregular menstruation, and their pathogenesis is spleen and kidney deficiency, and qi and blood deficiency. In case 1, the patients are mainly suffered from spleen deficiency and qi deficiency, so the dosage of the qi-tonifying, spleen-tonifying and blood-nourishing medicine is increased; example 2 the dosage of the kidney-tonifying, essence-replenishing and blood-nourishing medicine is increased because of the heavy kidney deficiency and blood deficiency.

The traditional Chinese medicine composition is used for treating irregular menstruation; the traditional Chinese medicine adjuvant therapy of preceded menstrual cycle, later menstrual cycle, irregular menstrual cycle, intermenstrual bleeding, hypomenorrhea, amenorrhea, dysmenorrhea, infertility (primary or secondary infertility), threatened abortion, recurrent abortion (habitual abortion), IVF-ET (in vitro fertilization-embryo transplantation), abortion, small puerperal delivery, postpartum regulation, climacteric syndrome, alopecia, anemia and consumptive disease (sub-health state). Has good curative effect and safe and reliable medication.

Claims (6)

1. The kidney nourishing and blood nourishing paste is characterized in that the raw material medicines comprise, by weight, 10-50 parts of semen cuscutae, 10-40 parts of morinda officinalis, 10-30 parts of epimedium herb, 10-30 parts of cistanche, 10-30 parts of eucommia ulmoides, 10-50 parts of teasel root, 10-50 parts of glossy privet fruit, 10-50 parts of mulberry, 10-50 parts of codonopsis pilosula, 10-30 parts of bighead atractylodes rhizome, 10-30 parts of Chinese yam rhizome, 10-30 parts of angelica, 10-30 parts of white paeony root, 6-40 parts of radix rehmanniae recen and 6-30 parts of dendrobium.

2. The paste as claimed in claim 1, wherein the processed semen Cuscutae and Morindae officinalis salt can enter kidney channel to tonify kidney.

3. The paste for nourishing kidney and blood as claimed in claim 1, which is a paste and is prepared by the following process:

s1, decocting: soaking decoction pieces in the preparation in water for 1-4 hr, decocting for 2-3 times, filtering decoction after each decoction for 1-2 hr, squeezing decoction dregs, mixing squeezed liquid and filtered decoction, standing, clarifying, and filtering;

s2, concentrating: heating and concentrating the liquid obtained by standing, clarifying and filtering in the step S1 to obtain clear paste;

s3, refining honey: dissolving Mel in water, filtering, and heating and decocting to obtain refined Mel;

s4, collecting paste: adding refined honey into the clear paste, adding 300 g of refined honey into every 1000 g of clear paste, stirring, heating and decocting to obtain the paste in a white thread state.

4. The paste as claimed in claim 3, wherein the concentration is carried out by dropping the fluid extract on mulberry paper until there is no water leakage around the drop.

5. The kidney-nourishing blood-nourishing paste as claimed in claim 3, wherein in the honey refining process, the honey is heated until pale yellow glossy billowing uniform fine bubbles appear, the honey is twisted by hands to have stickiness, and no white thread appears optimally when two fingers are separated.

6. The paste as claimed in claim 3, wherein the paste is prepared by adding refined honey, stirring clockwise, and removing foam on the liquid surface when heating.